Fig. S1. Identification of TRAF6 ubiquitination upon S. Typhimurium infection. Fig. S2. Internalization of the S. Typhimurium effector-defective ΔinvA and ΔsopB ΔsopE2 mutants is mediated by invasin. Fig. S3. TRAF6 promotes entrance of STAT3 into the nucleus and intracellular bacterial replication. Fig. S4. Effect of chloramphenicol on STAT3 phosphorylation during S. Typhimurium infection. Fig. S5. TRAF6 catalyzes the formation of Lys63-linked polyubiquitin chains on STAT3 during S. Typhimurium infection. Fig. S6. Quantification of mutations in STAT3 SH2 domain lysine residues on ratio of membrane to total STAT3. Fig. S7. Effect of the absence of TRAF6 on STAT3 membrane recruitment and phosphorylation upon S. Typhimurium infection. Fig. S8. Effect of SopB/SopE2 on STAT3 phosphorylation upon S. Typhimurium infection.
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Legends for Fig. S1 to S8.
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