[Posted as supplied by author]

These data were presented in part at the annual meeting of the American College of Gastroenterology in Baltimore, MD, USA on October 14, 2003, and published in abstract form (Leontiadis et al., American Journal of Gastroenterology 2003; 98: S49). Subgroup analyses have been presented at the annual meeting of the American Gastroenterological Association in New Orleans, LA, USA on May 16 and May 19, 2004, and have also been published in abstract form (Leontiadis et al., Gastroenterology 2004; 126; A-193; Leontiadis et al., Gastroenterology 2004; 126: A-603). The full version of the review has been published in the Cochrane Database of Systematic Reviews (Leontiadis G I, McIntyre L, Sharma V K, Howden C W. Proton pump inhibitor treatment for acute peptic ulcer bleeding (Cochrane Review). In: The Cochrane Library, Issue 3, 2004. Chichester, UK: John Wiley & Sons, Ltd) and will be updated regularly.

References to trial included in meta-analysis

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w5 Lanas A, Artal A, Blas JM, Arroyo MT, Lopez-Zaborras J, Sainz R. Effect of parenteral omeprazole and ranitidine on gastric pH and the outcome of bleeding peptic ulcer. J Clin Gastroenterol 1995;21:103-6.

w6 Villanueva C, Balanzo J, Torras X, Sainz S, Soriano G, Gonzalez D, et al. Omeprazole versus ranitidine as adjunct therapy to endoscopic injection in actively bleeding ulcers: a prospective and randomized study. Endoscopy 1995;27:308-12.

w7 Cardi M, Muttillo I A, Amadori L, Barillari P, Sammartino P, Arnone F, et al. Omeprazole versus ranitidine intraveineux dans le traitement de l’ulcere duodenal hemorragique: une etude randomisee prospective. Ann Chir 1997:51;136-9.

w8 Hasselgren G, Lind T, Lundell L, Aadland E, Efskind P, Falk A, et al. Continuous intravenous infusion of omeprazole in elderly patients with peptic ulcer bleeding. Results of a placebo-controlled multicenter study. Scand J Gastroenterol 1997;32:328-33.

w9 Khuroo MS, Yattoo GN, Javid G, Khan BA, Shah AA, Gulzar GM, et al. A comparison of omeprazole and placebo for bleeding peptic ulcer. N Engl J Med 1997;336:1054-8.

w10 Labenz J, Peitz U, Leusing C, Tillenburg B, Blum A L, Borsch G. Efficacy of primed infusions with high dose ranitidine and omeprazole to maintain high intragastric pH in patients with peptic ulcer bleeding: a prospective randomised controlled study. Gut 1997;40:36-41.

w11 Lin HJ, Lo WC, Perng CL, Wang K, Lee FY. Can optimal acid suppression prevent rebleeding in peptic ulcer patients with a non-bleeding visible vessel: a preliminary report of a randomized comparative study. Hepatogastroenterology 1997;44:1495-9.

w12 Schaffalitzky de Muckadell OB, Havelund T, Harling H, Boesby S, Snel P, Vreeburg EM, et al. Effect of omeprazole on the outcome of endoscopically treated bleeding peptic ulcers. Randomized double-blind placebo-controlled multicentre study. Scand J Gastroenterol 1997;32:320-7.

w13 Coraggio F, Rotondano G, Marmo R, Balzanelli MG, Catalano A, Clemente F, et al. Somatostatin in the prevention of recurrent bleeding after endoscopic haemostasis of peptic ulcer haemorrhage: a preliminary report. Eur J Gastroenterol Hepatol 1998;10:673-6.

w14 Lin HJ, Lo WC, Lee FY, Perng CL, Tseng GY. A prospective randomized comparative trial showing that omeprazole prevents rebleeding in patients with bleeding peptic ulcer after successful endoscopic therapy. Arch Intern Med 1998;158:54-8.

w15 Lau JY, Sung JJ, Lee KK, Yung MY, Wong SK, Wu JC, et al. Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers. N Engl J Med 2000;343:310-6.

w16 Javid G, Masoodi I, Zargar SA, Khan BA, Yatoo GN, Shah AH, et al. Omeprazole as adjuvant therapy to endoscopic combination injection sclerotherapy for treating bleeding peptic ulcer. Am J Med 2001;111:280-4.

w17 Sheu BS, Chi CH, Huang CC, Kao AW, Wang YL, Yang HB. Impact of intravenous omeprazole on Helicobacter pylori eradication by triple therapy in patients with peptic ulcer bleeding. Aliment Pharmacol Ther 2002;16:137-43.

w18 Kaviani MJ, Hashemi MR, Kazemifar AR, Roozitalab S, Mostaghni AA, Merat S, et al. Effect of oral omeprazole in reducing re-bleeding in bleeding peptic ulcers: a prospective, double-blind, randomized, clinical trial. Aliment Pharmacol Ther 2003;17:211-6.

w19 Desprez D, Blank P, Bories JM, Pageaux P, David XR, Veyrac M, et al. Acute upper gastrointestinal hemorrhage: preliminary report of a randomized controlled trial comparing intravenous administration of ranitidine and omeprazole. Gastroenterology 1995;108:A82.

w20 Fried R, Beglinger C, Meier R, Stumpf J, Alder G, Schepp W, et al. Comparison of intravenous pantoprazole with intravenous ranitidine in peptic ulcer bleeding. Gut 1999;45(suppl V):A100.

w21 Duvnjak M, Supanc V, Troskot B, Kovacevic I, Antic Z, Hrabar D, et al. Comparison of intravenous pantoprazole with intravenous ranitidine in prevention of re-bleeding from gastroduodenal ulcers. Gut 2001;49(suppl III):2379.