Table 3. Screening for potential Stat3-inhibitory small-molecular compounds using Stat3 luciferase reporter gene expression in Caov-3 cloned cells

Compound	Luciferase reduction
STA-001	NT
STA-002	ą
STA-003	−
STA-004	+
STA-005	ą
STA-006	ą
STA-007	-
STA-008	-
STA-009	-
STA-010	-
STA-011	-
STA-012	ą
STA-013	-
STA-014	ą
STA-015	NT
STA-016	-
STA-017	ą
STA-018	-
STA-019	-
STA-020	+++
STA-021	+++
STA-022	++
STA-023	+++
STA-024	ą
STA-025	ą
STA-026	+
STA-027	-
STA-028	-
STA-029	-
STA-030	NT
STA-031	++
STA-032	-
STA-033	+
STA-034	++
STA-035	+
STA-036	ą
STA-037	ą
STA-038	ą
STA-039	-
STA-040	ą
STA-041	-
STA-042	-
STA-043	-
STA-044	-
STA-045	-
STA-046	-
STA-047	++
STA-048	-
STA-049	-
STA-050	+++
STA-051	+++
STA-052	++
STA-053	++
STA-054	-
STA-055	ą
STA-056	-
STA-057	-
STA-058	-
STA-059	NT
STA-060	-
STA-061	+++
STA-062	-
STA-063	-
STA-064	-
STA-065	++
STA-066	-
STA-067	+
STA-068	-
STA-069	-
STA-070	++
STA-071	+
STA-072	ą
STA-073	-
STA-074	+
STA-075	+++
STA-076	ą
STA-077	+++
STA-078	NT
STA-079	NT
STA-080	ą
STA-081	-
STA-082	+++
STA-083	NT
STA-084	-
STA-085	ą
STA-086	NT
STA-087	+
STA-088	+
STA-089	+
STA-090	ą
STA-091	+
STA-092	ą
STA-093	NT
STA-094	-
STA-095	NT
STA-096	-
STA-097	NT
STA-098	-
STA-099	-
STA-100	-

+++, Strong inhibition; ++, moderate inhibition; +, weak inhibition; ą, very weak inhibition; −, no inhibition; NT, not tested. Compound structures are shown Figs. 6 and 7. The 11 compounds (STA101-111) were tested by using MDA-MB-435s clone cells and did not show significant inhibition to Stat3. We did not list those compounds here.