Chemical chaperone 4-phenyl butyric acid (4-PBA) reduces hepatocellular lipid accumulation and lipotoxicity through induction of autophagy

Supplemental Data

• Supplementary Figure 1S (.pdf, 312 KB) - Supplement Figure S1: 4-PBA prevents palmitate induced lipid accumulation and lipo-toxicity in AML-12.
• Supplementary Figure 2S (.pdf, 225 KB) - Supplement Figure S2: 4-PBA restores palmitate induced impaired autophagy, in AML-12 cells and Huh-7 cells, and prevents palmitate induced lipo-toxicity in Huh-7 cells.
• Supplementary Figure 3S (.pdf, 254 KB) - Supplement Figure S3: Oleic acid does not impair autophagic flux in Huh-7 cells. Atg-5 silencing leads to increased TG accumulation, by palmitate in Huh-7 cells.