Commentary,EC_number,KEGG_ID,KI_Value,LigandID,Literature,Mechanism,Mode,Name,Organism,Source,bigg.metabolite,chebiID,bigg.reaction
,1.1.1.6,C00238,,39,668061,,+,Potassium cation,Escherichia coli,BRENDA,k,CHEBI:29103,glycdx
,1.1.1.49,C00315,,148,722577,,+,Spermidine,Escherichia coli,BRENDA,spmd,CHEBI:16610,g6pdh2r
,1.1.1.169,C00058,,120,286109,,+,Formate,Escherichia coli,BRENDA,for,CHEBI:30751,dpr
,1.1.1.336,C04501,,3651,720374,,+,N-Acetyl-alpha-D-glucosamine 1-phosphate,Escherichia coli,BRENDA,acgam1p,CHEBI:16446,uacmamo
,1.2.1.10,C00003,,7,390164,,+,NAD+,Escherichia coli,BRENDA,nad,CHEBI:15846,acald
,1.2.1.21,C00250,,608,390214,,+,Pyridoxal,Escherichia coli,BRENDA,pydx,CHEBI:17310,gcaldd
,1.2.1.21,C00018,,32,390214,,+,Pyridoxal phosphate,Escherichia coli,BRENDA,pydx5p,CHEBI:18405,gcaldd
,1.2.1.21,C00314,,1051,390214,,+,Pyridoxine,Escherichia coli,BRENDA,pydxn,CHEBI:16709,gcaldd
,1.2.1.22,,,153,288135,,+,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,lcadi
,1.4.1.4,C00020,,30,391685,,+,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,gludy
,1.4.1.4,C00002,,4,391685,,+,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,gludy
,1.4.1.4,C00075,,65,391675,,+,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,gludy
,1.4.3.16,C00049,,97,391760,,+,L-Aspartate,Escherichia coli,BRENDA,asp__l,CHEBI:17053,aspo6
,1.6.1.1,C00008,,13,725040,,+,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,thd2pp
,1.6.1.1,C00020,,30,725040,,+,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,thd2pp
,1.6.1.1,C00002,,4,725040,,+,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,thd2pp
,1.7.1.4,C00003,,7,392926,,+,NAD+,Escherichia coli,BRENDA,nad,CHEBI:15846,ntrir2x
,1.7.1.4,C00003,,7,392928,,+,NAD+,Escherichia coli,BRENDA,nad,CHEBI:15846,ntrir2x
,1.8.1.9,,,153,394918,,+,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,trdr
,1.8.1.9,,,153,394933,,+,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,trdr
,1.8.1.9,,,153,394946,,+,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,trdr
,1.8.1.9,C00009,,16,393993,,+,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,trdr
,1.11.1.6,,,1063,439802,,+,,Escherichia coli,BRENDA,his__l,CHEBI:57595,cat
,1.14.12.17,C00032,,822,285279,,+,Heme,Escherichia coli,BRENDA,pheme,CHEBI:26355,nodox
,1.17.4.1,C00002,,4,"437913, 437918, 437937, 437938",,+,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,rndr1
,1.17.4.1,C00002,,4,687294,,+,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,rndr1
,1.17.4.1,C00002,,4,714233,,+,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,rndr1
,1.17.4.1,C00002,,4,716317,,+,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,rndr1
,1.17.4.1,C00131,,140,437913,,+,dATP,Escherichia coli,BRENDA,datp,CHEBI:16284,rndr1
,1.17.4.1,C00131,,140,"437976, 714184",,+,dATP,Escherichia coli,BRENDA,datp,CHEBI:16284,rndr1
,1.17.4.1,C00458,,179,437918,,+,dCTP,Escherichia coli,BRENDA,dctp,CHEBI:16311,rndr1
,1.17.4.1,C00286,,219,437913,,+,dGTP,Escherichia coli,BRENDA,dgtp,CHEBI:16497,rndr1
,1.17.4.1,C00286,,219,437918,,+,dGTP,Escherichia coli,BRENDA,dgtp,CHEBI:16497,rndr1
,1.17.4.1,C00286,,219,437937,,+,dGTP,Escherichia coli,BRENDA,dgtp,CHEBI:16497,rndr1
,1.17.4.1,C00286,,219,437976,,+,dGTP,Escherichia coli,BRENDA,dgtp,CHEBI:16497,rndr1
,1.17.4.1,,,145,437913,,+,,Escherichia coli,BRENDA,dttp,CHEBI:37568,rndr1
,1.17.4.1,,,145,437918,,+,,Escherichia coli,BRENDA,dttp,CHEBI:37568,rndr1
,1.17.4.1,,,145,437937,,+,,Escherichia coli,BRENDA,dttp,CHEBI:37568,rndr1
,1.17.4.1,,,145,437938,,+,,Escherichia coli,BRENDA,dttp,CHEBI:37568,rndr1
,1.17.4.1,,,145,437976,,+,,Escherichia coli,BRENDA,dttp,CHEBI:37568,rndr1
,1.17.4.1,,,22,437927,,+,,Escherichia coli,BRENDA,h2o2,CHEBI:29192,rndr1
,2.1.1.10,,,153,441382,,+,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,hcysmt
,2.1.1.10,,,747,441382,,+,,Escherichia coli,BRENDA,hcys__l,CHEBI:58199,hcysmt
,2.1.1.10,,,5553,441382,,+,,Escherichia coli,BRENDA,hom__l,CHEBI:30653,hcysmt
,2.1.1.10,,,46234,441382,,+,,Escherichia coli,BRENDA,cyst__l,CHEBI:58161,hcysmt
,2.1.1.13,C00238,,39,441179,,+,Potassium cation,Escherichia coli,BRENDA,k,CHEBI:29103,mets
,2.1.1.13,C01330,,59,441179,,+,Sodium cation,Escherichia coli,BRENDA,na1,CHEBI:29101,mets
,2.1.1.13,C00019,,24,659993,,+,S-Adenosyl-L-methionine,Escherichia coli,BRENDA,amet,CHEBI:15414,mets
,2.1.1.13,C00019,,404,441179,,+,S-Adenosyl-L-methionine,Escherichia coli,BRENDA,amet,CHEBI:15414,mets
,2.1.1.79,C01353,,1136,680343,,+,Carbonic acid,Escherichia coli,BRENDA,hco3,CHEBI:28976,cfas160e
,2.1.2.1,,,95,718984,,+,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,ghmt2r
,2.1.3.2,C00212,,122,485837,,+,Adenosine,Escherichia coli,BRENDA,adn,CHEBI:16335,aspct
,2.1.3.2,C00002,,4,485838,,+,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,aspct
,2.1.3.2,C00002,,4,662646,,+,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,aspct
,2.1.3.2,C00002,,4,685252,,+,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,aspct
,2.1.3.2,C00002,,4,699559,,+,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,aspct
,2.1.3.2,C00002,,4,699578,,+,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,aspct
,2.1.3.2,,,60,662646,,+,,Escherichia coli,BRENDA,ctp,CHEBI:37563,aspct
,2.1.3.2,,,60,699578,,+,,Escherichia coli,BRENDA,ctp,CHEBI:37563,aspct
,2.1.3.2,C00149,,247,485853,,+,(S)-Malate,Escherichia coli,BRENDA,mal__l,CHEBI:30797,aspct
,2.1.3.2,C00042,,58,485853,,+,Succinate,Escherichia coli,BRENDA,succ,CHEBI:15741,aspct
,2.1.3.2,C00075,,65,662646,,+,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,aspct
,2.2.1.1,,,1126,694217,,+,,Escherichia coli,BRENDA,h2o2,CHEBI:29192,tkt1
,2.2.1.9,,,91,685086,,+,,Escherichia coli,BRENDA,thmpp,CHEBI:45931,sephchcs
,2.3.1.8,C00022,,31,487532,,+,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,pta2
,2.3.1.8,C00022,,31,720217,,+,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,pta2
,2.3.1.15,C00002,,4,486381,,+,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,g3pat120
,2.3.1.41,C00009,,16,486864,,+,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,3oas121
,2.3.1.54,C01444,,825,487222,,+,Oxamate,Escherichia coli,BRENDA,oxam,CHEBI:18058,obtfl
,2.3.1.54,C01444,,825,"487221, 487239",,+,Oxamate,Escherichia coli,BRENDA,oxam,CHEBI:18058,obtfl
,2.3.1.54,C00022,,31,"487221, 487239",,+,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,obtfl
,2.3.1.54,C00019,,404,"14936, 487219, 487222, 487230",,+,S-Adenosyl-L-methionine,Escherichia coli,BRENDA,amet,CHEBI:15414,obtfl
,2.3.1.54,C00019,,404,"487218, 487221, 487239",,+,S-Adenosyl-L-methionine,Escherichia coli,BRENDA,amet,CHEBI:15414,obtfl
,2.4.1.1,C00020,,236,488238,,+,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,glcp2
,2.4.1.21,,,131,"488903, 488914",,+,,Escherichia coli,BRENDA,cit,CHEBI:76049,glcs1
,2.4.1.227,C00076,,15,488971,,+,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,uagpt3
,2.4.1.227,C11143,,1217,488978,,+,Dimethyl sulfoxide,Escherichia coli,BRENDA,dmso,CHEBI:28262,uagpt3
,2.4.1.227,C11143,,896,703764,,+,Dimethyl sulfoxide,Escherichia coli,BRENDA,dmso,CHEBI:28262,uagpt3
,2.4.1.227,C00305,,6,"488971, 488973, 488974, 488976, 488978",,+,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,uagpt3
,2.4.2.8,C00033,,47,638391,,+,Acetate,Escherichia coli,BRENDA,ac,CHEBI:15366,adpt
,2.4.2.9,C00044,,37,638362,,+,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,upprt
,2.4.2.9,C00044,,37,638369,,+,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,upprt
,2.4.2.9,C00044,,37,638372,,+,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,upprt
,2.4.2.14,C00119,,111659,489747,,+,5-Phospho-alpha-D-ribose 1-diphosphate,Escherichia coli,BRENDA,prpp,CHEBI:17111,gluprt
,2.5.1.6,C00019,,404,639056,,+,S-Adenosyl-L-methionine,Escherichia coli,BRENDA,amet,CHEBI:15414,metat
,2.6.1.85,,,755,644230,,+,,Escherichia coli,BRENDA,gln__l,CHEBI:58359,adcs
,2.6.1.85,C00568,,45809,644230,,+,4-Aminobenzoate,Escherichia coli,BRENDA,4abz,CHEBI:30753,adcs
,2.7.1.11,C00008,,13,722736,,+,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,pfk
,2.7.1.11,C00035,,53,640489,,+,GDP,Escherichia coli,BRENDA,gdp,CHEBI:17552,pfk
,2.7.1.11,C00035,,53,"640490, 722736",,+,GDP,Escherichia coli,BRENDA,gdp,CHEBI:17552,pfk
,2.7.1.21,C00705,,1124,641132,,+,dCDP,Escherichia coli,BRENDA,dcdp,CHEBI:28846,durik1
,2.7.1.21,C00458,,179,"641123, 641132",,+,dCTP,Escherichia coli,BRENDA,dctp,CHEBI:16311,durik1
,2.7.1.21,C00044,,37,641123,,+,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,durik1
,2.7.1.25,,,74,641217,,+,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,adsk
,2.7.1.25,C00342,,121,641217,,+,Thioredoxin,Escherichia coli,BRENDA,trdrd,CHEBI:15033,adsk
,2.7.1.40,C00354,,106,707589,,+,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,pyk
,2.7.1.40,C00354,,583,641557,,+,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,pyk
,2.7.1.40,C00092,,105,641557,,+,D-Glucose 6-phosphate,Escherichia coli,BRENDA,g6p,CHEBI:4170,pyk
,2.7.1.40,C00074,,51,707589,,+,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,pyk
,2.7.1.73,C00238,,39,641925,,+,Potassium cation,Escherichia coli,BRENDA,k,CHEBI:29103,gsnk
,2.7.1.73,C00305,,6,641925,,+,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,gsnk
,2.7.1.89,C00002,,4,642072,,+,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,tmk
,2.7.1.107,,,51151,640361,,+,,Escherichia coli,BRENDA,pa160,CHEBI:73246,dagk160
,2.7.1.107,C00712,,380,640361,,+,(9Z)-Octadecenoic acid,Escherichia coli,BRENDA,ocdcea,CHEBI:16196,dagk160
,2.7.1.107,C00249,,535,640361,,+,Hexadecanoic acid,Escherichia coli,BRENDA,hdca,CHEBI:15756,dagk160
,2.7.1.107,C01530,,1359,640361,,+,Octadecanoic acid,Escherichia coli,BRENDA,ocdca,CHEBI:28842,dagk160
,2.7.6.5,C00469,,69,642773,,+,Ethanol,Escherichia coli,BRENDA,etoh,CHEBI:16236,gdpdpk
,2.7.7.12,,,153,642823,,+,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,uglt
,2.7.7.12,,,153,642834,,+,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,uglt
,2.7.7.27,C04442,,1482,643144,,+,2-Dehydro-3-deoxy-6-phospho-D-gluconate,Escherichia coli,BRENDA,2ddg6p,CHEBI:15925,glgc
,2.7.7.27,C00109,,371,643144,,+,2-Oxobutanoate,Escherichia coli,BRENDA,2obut,CHEBI:30831,glgc
,2.7.7.27,C00597,,194,"643114, 643141",,+,Glycerate 3-phosphate,Escherichia coli,BRENDA,3pg,CHEBI:17050,glgc
,2.7.7.27,C00597,,194,643144,,+,Glycerate 3-phosphate,Escherichia coli,BRENDA,3pg,CHEBI:17050,glgc
,2.7.7.27,C00597,,194,643164,,+,Glycerate 3-phosphate,Escherichia coli,BRENDA,3pg,CHEBI:17050,glgc
,2.7.7.27,C00008,,13,643141,,+,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,glgc
,2.7.7.27,C00020,,30,643141,,+,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,glgc
,2.7.7.27,C00020,,30,643161,,+,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,glgc
,2.7.7.27,C00354,,106,643127,,+,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,glgc
,2.7.7.27,C00354,,106,643144,,+,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,glgc
,2.7.7.27,C00354,,106,643152,,+,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,glgc
,2.7.7.27,C00354,,106,"643141, 643146, 643150, 643161, 643164, 661743, 663026",,+,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,glgc
,2.7.7.27,C00354,,106,671752,,+,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,glgc
,2.7.7.27,C00354,,583,674737,,+,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,glgc
,2.7.7.27,C00085,,87,"643131, 643141, 643144",,+,D-Fructose 6-phosphate,Escherichia coli,BRENDA,f6p,CHEBI:61553,glgc
,2.7.7.27,C00085,,87,643152,,+,D-Fructose 6-phosphate,Escherichia coli,BRENDA,f6p,CHEBI:61553,glgc
,2.7.7.27,C00085,,87,"643161, 643164",,+,D-Fructose 6-phosphate,Escherichia coli,BRENDA,f6p,CHEBI:61553,glgc
,2.7.7.27,C00092,,105,643141,,+,D-Glucose 6-phosphate,Escherichia coli,BRENDA,g6p,CHEBI:4170,glgc
,2.7.7.27,C00092,,105,643164,,+,D-Glucose 6-phosphate,Escherichia coli,BRENDA,g6p,CHEBI:4170,glgc
,2.7.7.27,C00673,,1398,643144,,+,2-Deoxy-D-ribose 5-phosphate,Escherichia coli,BRENDA,2dr5p,CHEBI:55513,glgc
,2.7.7.27,C00661,,574,643144,,+,Glyceraldehyde 3-phosphate,Escherichia coli,BRENDA,g3p,CHEBI:17138,glgc
,2.7.7.27,C00168,,389,643144,,+,Hydroxypyruvate,Escherichia coli,BRENDA,hpyr,CHEBI:30841,glgc
,2.7.7.27,C00006,,10,643144,,+,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,glgc
,2.7.7.27,C00005,,5,643144,,+,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,glgc
,2.7.7.27,C00074,,51,643144,,+,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,glgc
,2.7.7.27,C00074,,51,661743,,+,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,glgc
,2.7.7.27,C00018,,32,643141,,+,Pyridoxal phosphate,Escherichia coli,BRENDA,pydx5p,CHEBI:18405,glgc
,2.7.7.27,C00018,,32,643144,,+,Pyridoxal phosphate,Escherichia coli,BRENDA,pydx5p,CHEBI:18405,glgc
,2.7.7.27,C00018,,32,661743,,+,Pyridoxal phosphate,Escherichia coli,BRENDA,pydx5p,CHEBI:18405,glgc
,2.7.7.27,C00022,,31,643152,,+,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,glgc
,2.7.7.27,C00447,,869,643144,,+,"Sedoheptulose 1,7-bisphosphate",Escherichia coli,BRENDA,s17bp,CHEBI:17969,glgc
,2.7.7.41,C00002,,4,643314,,+,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,dasyn120
,3.1.3.11,,,131,680756,,+,,Escherichia coli,BRENDA,cit,CHEBI:76049,fbp
,3.1.3.11,C00074,,51,651666,,+,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,fbp
,3.1.3.11,C00074,,51,665719,,+,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,fbp
,3.1.3.11,C00074,,51,680756,,+,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,fbp
,3.1.3.11,C00059,,160,665719,,+,Sulfate,Escherichia coli,BRENDA,so4,CHEBI:26836,fbp
,3.1.3.18,C01327,,141,651727,,+,Hydrochloric acid,Escherichia coli,BRENDA,cl,CHEBI:17883,pglycp
,3.1.3.25,,,11,680809,,+,,Escherichia coli,BRENDA,mn2,CHEBI:29035,mi1pp
,3.2.2.4,C00002,,4,"171818, 657368",,+,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,ampn
,3.5.1.10,,,692,208968,,+,,Escherichia coli,BRENDA,met__l,CHEBI:57844,fthfd
,3.5.1.16,C00009,,16,171964,,+,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,acoda
,3.5.4.1,,,164,209497,,+,,Escherichia coli,BRENDA,ala__d,CHEBI:57416,csnd
,3.5.4.1,,,6515,209497,,+,,Escherichia coli,BRENDA,hom__l,CHEBI:30653,csnd
,3.5.4.1,,,72,209497,,+,,Escherichia coli,BRENDA,gly,CHEBI:57305,csnd
,3.5.4.1,C00049,,1353,209489,,+,L-Aspartate,Escherichia coli,BRENDA,asp__l,CHEBI:17053,csnd
,3.5.4.1,C00049,,1353,209497,,+,L-Aspartate,Escherichia coli,BRENDA,asp__l,CHEBI:17053,csnd
,3.5.4.1,C00025,,1163,209489,,+,L-Glutamate,Escherichia coli,BRENDA,glu__l,CHEBI:16015,csnd
,3.5.4.1,C00025,,1163,209497,,+,L-Glutamate,Escherichia coli,BRENDA,glu__l,CHEBI:16015,csnd
,3.5.4.1,,,102,209489,,+,,Escherichia coli,BRENDA,gln__l,CHEBI:58359,csnd
,3.5.4.1,,,102,209497,,+,,Escherichia coli,BRENDA,gln__l,CHEBI:58359,csnd
,3.5.4.1,,,349,209489,,+,,Escherichia coli,BRENDA,his__l,CHEBI:57595,csnd
,3.5.4.1,,,349,209497,,+,,Escherichia coli,BRENDA,his__l,CHEBI:57595,csnd
,3.5.4.1,,,311,209497,,+,,Escherichia coli,BRENDA,ile__l,CHEBI:58045,csnd
,3.5.4.1,,,127,209497,,+,,Escherichia coli,BRENDA,leu__l,CHEBI:57427,csnd
,3.5.4.1,C00077,,192,209497,,+,L-Ornithine,Escherichia coli,BRENDA,orn,CHEBI:15729,csnd
,3.5.4.1,,,104,209497,,+,,Escherichia coli,BRENDA,phe__l,CHEBI:58095,csnd
,3.5.4.1,,,95,209497,,+,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,csnd
,3.5.4.1,,,250,209497,,+,,Escherichia coli,BRENDA,thr__l,CHEBI:57926,csnd
,3.5.4.1,,,246,209497,,+,,Escherichia coli,BRENDA,val__l,CHEBI:57762,csnd
,3.5.4.5,C00475,,372,209659,,+,Cytidine,Escherichia coli,BRENDA,cytd,CHEBI:17562,cytd
,3.5.99.6,C00357,,1930,648215,,+,N-Acetyl-D-glucosamine 6-phosphate,Escherichia coli,BRENDA,acgam6p,CHEBI:15784,g6pda
,3.5.99.6,C00357,,1930,648220,,+,N-Acetyl-D-glucosamine 6-phosphate,Escherichia coli,BRENDA,acgam6p,CHEBI:15784,g6pda
,3.5.99.6,C00357,,1930,"648226, 648237, 648238, 648240, 648243",,+,N-Acetyl-D-glucosamine 6-phosphate,Escherichia coli,BRENDA,acgam6p,CHEBI:15784,g6pda
,3.5.99.6,C00357,,58095,712289,,+,N-Acetyl-D-glucosamine 6-phosphate,Escherichia coli,BRENDA,acgam6p,CHEBI:15784,g6pda
,3.6.1.1,C00002,,4,685305,,+,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,ppa
,3.6.3.5,,,132776,667819,,+,,Escherichia coli,BRENDA,pg160,CHEBI:60724,zn2abcpp
,3.6.3.5,,,132777,667819,,+,,Escherichia coli,BRENDA,pg180,CHEBI:61056,zn2abcpp
,3.6.3.5,,,74,654606,,+,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,zn2abcpp
,3.6.3.12,C00008,,13,289111,,+,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,kabcpp
,3.6.3.12,C00002,,4,"289111, 289116",,+,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,kabcpp
,3.6.3.16,C06697,,397,"210282, 210287",,+,Arsenite,Escherichia coli,BRENDA,aso3,CHEBI:49900,aso3t8pp
,3.6.3.16,C06697,,397,696278,,+,Arsenite,Escherichia coli,BRENDA,aso3,CHEBI:49900,aso3t8pp
,4.1.1.8,C00008,,13,714955,,+,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,oxcdc
,4.1.1.8,C00020,,30,714955,,+,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,oxcdc
,4.1.1.8,C00002,,4,714955,,+,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,oxcdc
,4.1.1.15,C01327,,141,3973,,+,Hydrochloric acid,Escherichia coli,BRENDA,cl,CHEBI:17883,asp1dc
,4.1.1.31,C00354,,93409,4286,,+,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,ppc
,4.1.1.31,C00044,,37,4286,,+,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,ppc
,4.1.1.49,C00024,,29,727382,,+,Acetyl-CoA,Escherichia coli,BRENDA,accoa,CHEBI:15351,ppck
,4.1.1.50,C00022,,31,4660,,+,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,admdc
,4.1.1.50,C00022,,31,4662,,+,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,admdc
,4.1.1.50,C00022,,31,"4668, 4672",,+,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,admdc
,4.1.1.65,C00022,,31,4780,,+,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,psd120
,4.1.1.65,C00022,,31,4783,,+,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,psd120
,4.1.1.65,C00022,,31,4785,,+,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,psd120
,4.1.1.65,C00022,,31,4790,,+,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,psd120
,4.1.1.98,C00725,,3823,729319,,+,Lipoate,Escherichia coli,BRENDA,lipoate,CHEBI:30314,ophbdc
,4.1.1.98,C00132,,83,729319,,+,Methanol,Escherichia coli,BRENDA,meoh,CHEBI:17790,ophbdc
,4.1.2.13,C00026,,34,4914,,+,2-Oxoglutarate,Escherichia coli,BRENDA,akg,CHEBI:30915,fba
,4.1.2.13,,,131,4914,,+,,Escherichia coli,BRENDA,cit,CHEBI:76049,fba
,4.1.2.13,C00074,,51,4914,,+,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,fba
,4.1.2.13,,,422,4914,,+,,Escherichia coli,BRENDA,glyc3p,CHEBI:57597,fba
,4.1.3.6,C00864,,1509,33364,,+,Pantothenate,Escherichia coli,BRENDA,pnto__r,CHEBI:46905,citl
,4.2.1.7,,,553,33957,,+,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,altrh
,4.2.1.47,C00005,,5,5732,,+,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,gmand
,4.2.1.79,C00163,,312,653158,,+,Propanoate,Escherichia coli,BRENDA,ppa,CHEBI:30768,mcitd
,4.2.3.3,C00988,,1798,650248,,+,2-Phosphoglycolate,Escherichia coli,BRENDA,2pglyc,CHEBI:17150,mgsa
,4.3.1.1,C11143,,985,6001,,+,Dimethyl sulfoxide,Escherichia coli,BRENDA,dmso,CHEBI:28262,aspt
,4.3.1.1,C00116,,135,6001,,+,Glycerol,Escherichia coli,BRENDA,glyc,CHEBI:17754,aspt
,4.3.1.1,C00049,,97,6021,,+,L-Aspartate,Escherichia coli,BRENDA,asp__l,CHEBI:17053,aspt
,4.3.1.19,,,835,"210856, 210863",,+,,Escherichia coli,BRENDA,val__l,CHEBI:57762,serd_l
,5.1.1.3,C01212,,20562,"2102, 2113",,+,UDP-N-acetylmuramoyl-L-alanine,Escherichia coli,BRENDA,uama,CHEBI:84726,glur
,5.1.1.3,C01212,,20562,"2111, 2115",,+,UDP-N-acetylmuramoyl-L-alanine,Escherichia coli,BRENDA,uama,CHEBI:84726,glur
,5.1.3.2,C00015,,26,650515,,+,UDP,Escherichia coli,BRENDA,udp,CHEBI:17659,udpg4e
,5.1.3.2,C00105,,133,650515,,+,UMP,Escherichia coli,BRENDA,ump,CHEBI:16695,udpg4e
,5.1.3.14,C00043,,126,661247,,+,UDP-N-acetyl-alpha-D-glucosamine,Escherichia coli,BRENDA,uacgam,CHEBI:16264,uag2e
,5.1.3.14,C00043,,383,"2264, 2265, 2268",,+,UDP-N-acetyl-alpha-D-glucosamine,Escherichia coli,BRENDA,uacgam,CHEBI:16264,uag2e
,5.4.2.7,C01151,,44769,3340,,+,"D-Ribose 1,5-bisphosphate",Escherichia coli,BRENDA,r15bp,CHEBI:17994,ppm2
,5.4.2.7,C01151,,44769,3343,,+,"D-Ribose 1,5-bisphosphate",Escherichia coli,BRENDA,r15bp,CHEBI:17994,ppm2
,5.4.3.8,C00189,,456,3432,,+,Ethanolamine,Escherichia coli,BRENDA,etha,CHEBI:16000,g1sat
,5.4.99.9,C00005,,40,726820,,+,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,udpgalm
,6.1.1.5,C00315,,148,454,,+,Spermidine,Escherichia coli,BRENDA,spmd,CHEBI:16610,iletrs
,6.1.1.5,C00315,,148,462,,+,Spermidine,Escherichia coli,BRENDA,spmd,CHEBI:16610,iletrs
,6.1.1.19,C00315,,148,270,,+,Spermidine,Escherichia coli,BRENDA,spmd,CHEBI:16610,argtrs
,6.3.1.2,,,21728,667442,,+,,Escherichia coli,BRENDA,glyb,CHEBI:41139,glns
,6.3.1.2,C00137,,454,667442,,+,myo-Inositol,Escherichia coli,BRENDA,inost,CHEBI:17268,glns
,6.3.1.2,,,1625,667442,,+,,Escherichia coli,BRENDA,pro__l,CHEBI:60039,glns
,6.3.2.10,C00033,,47,651110,,+,Acetate,Escherichia coli,BRENDA,ac,CHEBI:15366,ugmdds
,6.3.2.10,C00246,,462,651110,,+,Butanoic acid,Escherichia coli,BRENDA,but,CHEBI:30772,ugmdds
,6.3.2.10,C00058,,120,651110,,+,Formate,Escherichia coli,BRENDA,for,CHEBI:30751,ugmdds
,6.3.2.10,C00163,,312,651110,,+,Propanoate,Escherichia coli,BRENDA,ppa,CHEBI:30768,ugmdds
,6.3.4.2,C00286,,5697,674909,,+,dGTP,Escherichia coli,BRENDA,dgtp,CHEBI:16497,ctps2
,6.3.4.2,C00044,,37,648962,,+,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,ctps2
,6.3.4.2,C00044,,37,648963,,+,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,ctps2
,6.3.4.2,C00044,,37,661241,,+,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,ctps2
,6.3.4.2,C00044,,37,674909,,+,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,ctps2
,6.3.4.2,C00044,,37,690817,,+,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,ctps2
,6.3.4.2,C00044,,37,702613,,+,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,ctps2
,6.3.4.2,C00081,,229,674909,,+,ITP,Escherichia coli,BRENDA,itp,CHEBI:16039,ctps2
,6.3.5.5,C00044,,37,1731,,+,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,cbps
,6.3.5.5,C00130,,232,649457,,+,IMP,Escherichia coli,BRENDA,imp,CHEBI:17202,cbps
,6.3.5.5,C00130,,232,649895,,+,IMP,Escherichia coli,BRENDA,imp,CHEBI:17202,cbps
,6.3.5.5,C00130,,232,650020,,+,IMP,Escherichia coli,BRENDA,imp,CHEBI:17202,cbps
,6.3.5.5,C00130,,232,652334,,+,IMP,Escherichia coli,BRENDA,imp,CHEBI:17202,cbps
,6.3.5.5,C00130,,232,"651882, 652788",,+,IMP,Escherichia coli,BRENDA,imp,CHEBI:17202,cbps
,6.3.5.5,C00130,,232,652823,,+,IMP,Escherichia coli,BRENDA,imp,CHEBI:17202,cbps
,6.3.5.5,C00081,,229,1731,,+,ITP,Escherichia coli,BRENDA,itp,CHEBI:16039,cbps
,6.3.5.5,C00077,,192,649457,,+,L-Ornithine,Escherichia coli,BRENDA,orn,CHEBI:15729,cbps
,6.3.5.5,C00077,,192,649877,,+,L-Ornithine,Escherichia coli,BRENDA,orn,CHEBI:15729,cbps
,6.3.5.5,C00077,,192,650020,,+,L-Ornithine,Escherichia coli,BRENDA,orn,CHEBI:15729,cbps
,6.3.5.5,C00077,,192,650798,,+,L-Ornithine,Escherichia coli,BRENDA,orn,CHEBI:15729,cbps
,6.3.5.5,C00077,,192,652334,,+,L-Ornithine,Escherichia coli,BRENDA,orn,CHEBI:15729,cbps
,6.3.5.5,C00077,,192,"651471, 651882, 651937, 652351, 652788",,+,L-Ornithine,Escherichia coli,BRENDA,orn,CHEBI:15729,cbps
,6.3.5.5,C00624,,3480,1725,,+,N-Acetyl-L-glutamate,Escherichia coli,BRENDA,acglu,CHEBI:17533,cbps
,6.3.5.5,C00077,,3657,1729,,+,L-Ornithine,Escherichia coli,BRENDA,orn,CHEBI:15729,cbps
,6.3.5.5,C00077,,3657,"1725, 1731",,+,L-Ornithine,Escherichia coli,BRENDA,orn,CHEBI:15729,cbps
,6.3.5.5,C00077,,576,"649886, 649895, 650927, 651292, 652823",,+,L-Ornithine,Escherichia coli,BRENDA,orn,CHEBI:15729,cbps
,6.3.5.5,C00077,,576,693247,,+,L-Ornithine,Escherichia coli,BRENDA,orn,CHEBI:15729,cbps
,6.3.5.5,C00238,,55194,"650936, 651937",,+,Potassium cation,Escherichia coli,BRENDA,k,CHEBI:29103,cbps
,6.3.5.5,C00655,,1007,1731,,+,Xanthosine 5'-phosphate,Escherichia coli,BRENDA,xmp,CHEBI:15652,cbps
,6.4.1.2,C00120,,143,665523,,+,Biotin,Escherichia coli,BRENDA,btn,CHEBI:15956,accoac
,6.4.1.2,C00120,,143,665526,,+,Biotin,Escherichia coli,BRENDA,btn,CHEBI:15956,accoac
,6.4.1.2,,,131,37593,,+,,Escherichia coli,BRENDA,cit,CHEBI:76049,accoac
,1.1.1.3,,,5553,246400,,-,,Escherichia coli,BRENDA,hom__l,CHEBI:30653,hsdy
,1.1.1.3,,,74,246398,,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,hsdy
,1.1.1.3,,,95,246398,,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,hsdy
,1.1.1.3,,,250,"246387, 246398",,-,,Escherichia coli,BRENDA,thr__l,CHEBI:57926,hsdy
,1.1.1.3,C00006,,10,246400,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,hsdy
,1.1.1.6,,,19,636295,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,glycdx
,1.1.1.6,C14819,,70,636295,,-,Fe3+,Escherichia coli,BRENDA,fe3,CHEBI:29034,glycdx
over 90% inhibition at 0.01 mM,1.1.1.6,C00038,,14,636295,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,glycdx
,1.1.1.22,C00004,,8,286293,,-,NADH,Escherichia coli,BRENDA,nadh,CHEBI:16908,udpgd
,1.1.1.22,C00167,,630,286293,,-,UDP-glucuronate,Escherichia coli,BRENDA,udpglcur,CHEBI:17200,udpgd
"2.2 mM, 50% inhibition, reversible",1.1.1.23,,,116,286332,,-,,Escherichia coli,BRENDA,urea,CHEBI:32285,histd
,1.1.1.28,C00008,,13,286430,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,ldh_d
,1.1.1.28,C00002,,4,286430,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,ldh_d
,1.1.1.28,C01444,,825,286430,,-,Oxamate,Escherichia coli,BRENDA,oxam,CHEBI:18058,ldh_d
,1.1.1.40,C00076,,15,722940,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,me2
,1.1.1.40,C00175,,23,722940,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,me2
strong inhibition,1.1.1.40,,,19,722940,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,me2
"activates at up to 4 mM, inhibition above, probably due to blockage of substrate binding, Km is 0.19 mM",1.1.1.40,C00305,,6,687388,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,me2
strong inhibition,1.1.1.40,C00038,,14,722940,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,me2
"allosteric inhibition. Phosphoenolpyruvate enhances the uncompetitive inhibition of isocitrate lyase by increasing isocitrate, which protects isocitrate dehydrogenase from the inhibition, and contributes to the control through the tricarboxylic acid cycle and glyoxylate shunt",1.1.1.42,C00074,,51,680481,,-,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,icdhyr
,1.1.1.44,C00002,,4,"286861, 286882, 286904",,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,gnd
,1.1.1.44,C00354,,583,"286851, 286861, 286882, 286904",,-,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,gnd
,1.1.1.44,C00005,,5,"286851, 286882, 286904",,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,gnd
"10 mM, 50-75% inhibition, assay without MgCl2",1.1.1.49,C00002,,4,722473,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,g6pdh2r
"1 mM, 83% inhibition",1.1.1.49,C01413,,52,722473,,-,Cadmium,Escherichia coli,BRENDA,cd2,CHEBI:48775,g6pdh2r
"1 mM, 56% inhibition",1.1.1.49,C00175,,23,722473,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,g6pdh2r
"1 mM, complete inhibition",1.1.1.49,,,19,722473,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,g6pdh2r
"1 mM, complete inhibition",1.1.1.49,C00703,,33,722473,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,g6pdh2r
"1 mM, 56% inhibition",1.1.1.49,,,11,722473,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,g6pdh2r
"allosteric inhibition, inhibition is not reversed by NAD+, AMP, or spermidine",1.1.1.49,C00004,,8,722577,,-,NADH,Escherichia coli,BRENDA,nadh,CHEBI:16908,g6pdh2r
product inhibition with NADP+ or D-glucose 6-phosphate as the varying substrate,1.1.1.49,C00005,,5,722244,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,g6pdh2r
,1.1.1.49,C00005,,5,722473,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,g6pdh2r
"when NADP+ is the varied substrate, NADPH NADPH is a competitive inhibitor both in the presence and absence of Mg2+, linear competitive inhibition. When glucose 6-phosphate is the varied substrate NADPH causes linear noncompetitive inhibition",1.1.1.49,C00005,,5,722577,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,g6pdh2r
competitive,1.1.1.57,C00002,,4,287131,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,manao
non-competitive,1.1.1.57,C00002,,4,"287132, 287133",,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,manao
non-competitive,1.1.1.57,C00817,,7175,287131,,-,D-Altronate,Escherichia coli,BRENDA,altrn,CHEBI:46644,manao
,1.1.1.57,C00817,,7175,287132,,-,D-Altronate,Escherichia coli,BRENDA,altrn,CHEBI:46644,manao
competitive at low concentrations; non-competitive,1.1.1.57,C00817,,7175,287133,,-,D-Altronate,Escherichia coli,BRENDA,altrn,CHEBI:46644,manao
non-competitive,1.1.1.57,C00514,,3998,287131,,-,D-Mannonate,Escherichia coli,BRENDA,mana,CHEBI:33076,manao
competitive,1.1.1.57,C00003,,7,287131,,-,NAD+,Escherichia coli,BRENDA,nad,CHEBI:15846,manao
,1.1.1.58,C00002,,4,"287138, 287140",,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,tagurr
,1.1.1.58,C00905,,96511,287140,,-,D-Fructuronate,Escherichia coli,BRENDA,fruur,CHEBI:4126,tagurr
inhibitory for forward and reverse reaction,1.1.1.58,C00514,,94003,287140,,-,D-Mannonate,Escherichia coli,BRENDA,mana,CHEBI:33076,tagurr
"with acetolactate as substrate, Mn2+ behaves as a competitive inhibitor in presence of Mg2+",1.1.1.86,,,11,639175,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,kara1
,1.1.1.86,C00006,,10,639175,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,kara1
,1.1.1.86,C00005,,5,639183,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,kara1
,1.1.1.94,C00008,,13,669177,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,g3pd2
,1.1.1.94,C13050,,402,669177,,-,Cyclic ADP-ribose,Escherichia coli,BRENDA,adprib,CHEBI:31445,g3pd2
,1.1.1.94,C00020,,30,669177,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,g3pd2
,1.1.1.94,C00002,,4,669177,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,g3pd2
noncompetitive versus NADP+,1.1.1.94,C00111,,278,669175,,-,Glycerone phosphate,Escherichia coli,BRENDA,dhap,CHEBI:16108,g3pd2
"0.05 mM, 26% inhibition",1.1.1.94,,,4581,287523,,-,,Escherichia coli,BRENDA,glyc3p,CHEBI:57597,g3pd2
competitive inhibitor,1.1.1.94,C00661,,5971,689802,,-,Glyceraldehyde 3-phosphate,Escherichia coli,BRENDA,g3p,CHEBI:17138,g3pd2
competitive inhibitor,1.1.1.94,C00631,,68873,689802,,-,2-Phospho-D-glycerate,Escherichia coli,BRENDA,2pg,CHEBI:17835,g3pd2
"50% inhibition with 0.035 mM, sigmoid inhibition curve, competitive inhibition vs. glycerone phosphate, uncompetitive vs. NADPH",1.1.1.94,,,445,287523,,-,,Escherichia coli,BRENDA,glyc3p,CHEBI:57597,g3pd2
,1.1.1.94,C00003,,7,669177,,-,NAD+,Escherichia coli,BRENDA,nad,CHEBI:15846,g3pd2
competitive versus NADPH,1.1.1.94,C00006,,10,669175,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,g3pd2
,1.1.1.94,C00006,,10,669177,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,g3pd2
competitive versus NADP+,1.1.1.94,C00005,,5,669175,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,g3pd2
,1.1.1.94,,,775,669177,,-,,Escherichia coli,BRENDA,nmn,CHEBI:14648,g3pd2
"0.0015 mM, 52% inhibition",1.1.1.94,,,128,287523,,-,,Escherichia coli,BRENDA,pmtcoa,CHEBI:57379,g3pd2
competitive inhibitor,1.1.1.94,C00074,,51,689802,,-,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,g3pd2
"product inhibition at an allosteric, regulatory site, competitive versus dihydroxyacetone phosphate, noncompetitive versus NADPH, the wild-type enzyme is feedback inhibited",1.1.1.94,,,4869,669175,,-,,Escherichia coli,BRENDA,glyc3p,CHEBI:57597,g3pd2
"the wild-type enzyme is feedback regulated, competitive versus dihydroxyacetone phosphate, binding to a regulatory site",1.1.1.94,,,4869,669177,,-,,Escherichia coli,BRENDA,glyc3p,CHEBI:57597,g3pd2
,1.1.1.95,C00597,,194,287546,,-,Glycerate 3-phosphate,Escherichia coli,BRENDA,3pg,CHEBI:17050,pgcd
inhibition can be overcome by addition of dithiothreitol,1.1.1.95,,,75,287530,,-,,Escherichia coli,BRENDA,ag,CHEBI:49468,pgcd
slightly,1.1.1.95,,,494,287548,,-,,Escherichia coli,BRENDA,ala_b,CHEBI:57966,pgcd
,1.1.1.95,,,72,287546,,-,,Escherichia coli,BRENDA,gly,CHEBI:57305,pgcd
,1.1.1.95,,,103,287525,,-,,Escherichia coli,BRENDA,ala__l,CHEBI:57972,pgcd
,1.1.1.95,,,7217,287525,,-,,Escherichia coli,BRENDA,athr__l,CHEBI:58585,pgcd
,1.1.1.95,,,345,287525,,-,,Escherichia coli,BRENDA,hom__l,CHEBI:57476,pgcd
binding of the inhibitor to the apoenzyme displays positive cooperativity in the binding of the first two serine molecules and negative cooperativity in the binding of the last two serine molecules. At least two NADH-induced conformational forms of the enzyme bind the inhibitor in the physiological range. Successive binding of NADH to the enzyme results in an increase in the affinity for the first inhibitor ligand bound and a lessening of both the positive and negative cooperativity of inhibitor binding,1.1.1.95,,,262,656083,,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,pgcd
50% inhibition at 0.005 mM and pH 7.5,1.1.1.95,,,95,287525,,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,pgcd
"inhibition of enzyme from E. coli, Salmonella typhimurium and Haemophilus influenzae, not of mammalian enzyme, inhibition in both reaction directions",1.1.1.95,,,95,287530,,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,pgcd
"allosteric inhibition, regulates the pathway of serine biosynthesis by end product inhibition interacting with His344, Asn346 and Asn364",1.1.1.95,,,95,"287546, 287547",,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,pgcd
"50% inhibition at 0.008 mM L-serine; allosteric inhibition, regulates the pathway of serine biosynthesis by end product inhibition interacting with His344, Asn346 and Asn364",1.1.1.95,,,95,287548,,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,pgcd
"feedback regulation, positive and negative cooperativity in absence of NADH, positive in presence of NADH, overview",1.1.1.95,,,95,663605,,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,pgcd
"the enzyme contains an ACT regulatory domain which binds L-serine for feedback regulation, binding site lies around residues H344-N364",1.1.1.95,,,95,667649,,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,pgcd
"physiological inhibitor, exerts its effect on at least two steps in the kinetic mechanism. There is a small but significant effect on the dissociation constant of NADH, increasing the Kd to 5 and 23 microM from 0.6 and 9 microM, respectively, for the two sets of sites in the enzyme. After the second substrate is added, serine reduces the amplitude of the signal without a significant effect on the observed rate constants for binding. The serine concentration that reduces the amplitude by 50% is equal to the K0.5 for serine inhibition. Serine binding eliminates a conformational change subsequent to substrate binding by formation of a dead-end quaternary complex consisting of enzyme, coenzyme, substrate, and effector. The rate data conform to a model in which serine can bind to two forms of the enzyme with different affinities",1.1.1.95,,,95,711203,,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,pgcd
,1.1.1.95,,,95,"287551, 687564, 724307",,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,pgcd
,1.1.1.95,,,250,287525,,-,,Escherichia coli,BRENDA,thr__l,CHEBI:57926,pgcd
inhibition of phosphoglycerate oxidation,1.1.1.95,C00004,,8,287525,,-,NADH,Escherichia coli,BRENDA,nadh,CHEBI:16908,pgcd
competitive product inhibition,1.1.1.100,C00006,,10,669013,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,3oar121
"potent inhibitor, IC50: 0.0075 mM",1.1.1.140,C00275,,700,669655,,-,D-Mannose 6-phosphate,Escherichia coli,BRENDA,man6p,CHEBI:48066,sbtpd
competitive,1.1.1.169,C00008,,13,669806,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,dpr
competitive,1.1.1.169,C00020,,30,669806,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,dpr
noncompetitive,1.1.1.169,C00002,,4,669806,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,dpr
"competitive versus NADPH, noncompetitive versus ketopantoate",1.1.1.169,C00006,,10,286108,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,dpr
noncompetitive versus ketopantoate and NADPH,1.1.1.169,C00522,,2576,286108,,-,(R)-Pantoate,Escherichia coli,BRENDA,pant__r,CHEBI:14737,dpr
competitive,1.1.1.169,C00009,,16,669806,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,dpr
,1.1.1.205,C00008,,13,347946,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,impd
,1.1.1.205,C00020,,30,347946,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,impd
,1.1.1.205,C00002,,4,347946,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,impd
competitive inhibition with respect to both K+ and NAD+,1.1.1.205,C00076,,15,701583,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,impd
,1.1.1.205,C00035,,53,347946,,-,GDP,Escherichia coli,BRENDA,gdp,CHEBI:17552,impd
competitive with respect to IMP and non competitive with respect to NAD+,1.1.1.205,C00144,,162,347909,,-,GMP,Escherichia coli,BRENDA,gmp,CHEBI:17345,impd
competitive with respect to IMP,1.1.1.205,C00144,,162,347938,,-,GMP,Escherichia coli,BRENDA,gmp,CHEBI:17345,impd
"; weak and competitive inhibition, strong binding, dissociation by 3 M urea",1.1.1.205,C00144,,162,347941,,-,GMP,Escherichia coli,BRENDA,gmp,CHEBI:17345,impd
,1.1.1.205,C00144,,162,"347939, 347946",,-,GMP,Escherichia coli,BRENDA,gmp,CHEBI:17345,impd
,1.1.1.205,C00044,,37,347946,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,impd
inhibits K+ activation,1.1.1.205,C00305,,6,347946,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,impd
competitive inhibition with respect to both K+ and NAD+,1.1.1.205,C00305,,6,701583,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,impd
competitive inhibition with respect to both K+ and NAD+,1.1.1.205,C01330,,59,701583,,-,Sodium cation,Escherichia coli,BRENDA,na1,CHEBI:29101,impd
,1.1.1.205,C01330,,59,703193,,-,Sodium cation,Escherichia coli,BRENDA,na1,CHEBI:29101,impd
,1.1.1.205,C00655,,1515,347946,,-,Xanthosine 5'-phosphate,Escherichia coli,BRENDA,xmp,CHEBI:15652,impd
,1.1.1.267,,,19,286427,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,dxprii
,1.1.1.267,C14818,,25,286427,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,dxprii
competitive with respect to GDP-4-keto-6-deoxymannose,1.1.1.271,C00035,,53,389515,,-,GDP,Escherichia coli,BRENDA,gdp,CHEBI:17552,gdmane
competitive inhibitor,1.1.1.271,C00006,,2088,389515,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,gdmane
,1.1.99.33,C00058,,120,698687,,-,Formate,Escherichia coli,BRENDA,for,CHEBI:30751,fhl
"10 mM NaNO3, 50% inhibition",1.1.99.33,,,308,698686,,-,,Escherichia coli,BRENDA,no3,CHEBI:17632,fhl
"10 mM NaNO2, 55% inhibition",1.1.99.33,C00088,,168,698686,,-,Nitrite,Escherichia coli,BRENDA,no2,CHEBI:25567,fhl
complete inhibition at 1 mM,1.2.1.3,,,75,690591,,-,,Escherichia coli,BRENDA,ag,CHEBI:49468,abutd
50.3% residual activity at 1 mM,1.2.1.3,C00175,,23,690591,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,abutd
2.9% residual activity at 1 mM,1.2.1.3,,,19,690591,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,abutd
57.5% residual activity at 1 mM,1.2.1.3,C14818,,25,690591,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,abutd
complete inhibition at 1 mM,1.2.1.3,C00703,,33,690591,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,abutd
95.3% residual activity at 1 mM,1.2.1.3,C00238,,39,690591,,-,Potassium cation,Escherichia coli,BRENDA,k,CHEBI:29103,abutd
80.6% residual activity at 1 mM,1.2.1.3,C00305,,6,690591,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,abutd
84.8% residual activity at 1 mM,1.2.1.3,,,11,690591,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,abutd
83.6% residual activity at 1 mM,1.2.1.3,C01330,,59,690591,,-,Sodium cation,Escherichia coli,BRENDA,na1,CHEBI:29101,abutd
72.4% residual activity at 1 mM,1.2.1.3,,,38,690591,,-,,Escherichia coli,BRENDA,ni2,CHEBI:49786,abutd
7% residual activity at 1 mM,1.2.1.3,C00038,,14,690591,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,abutd
"100 mM, 83% inhibition",1.2.1.8,C00084,,90,390329,,-,Acetaldehyde,Escherichia coli,BRENDA,acald,CHEBI:15343,betaldhx
above 0.5 mM,1.2.1.8,C00576,,831,390329,,-,Betaine aldehyde,Escherichia coli,BRENDA,betald,CHEBI:15710,betaldhx
"10 mM CaCl2, 90% inhibition",1.2.1.8,C00076,,15,390350,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,betaldhx
"100 mM, 78% inhibition",1.2.1.8,,,149,390329,,-,,Escherichia coli,BRENDA,chol,CHEBI:72322,betaldhx
"100 mM, 35% inhibition",1.2.1.8,C00189,,456,390329,,-,Ethanolamine,Escherichia coli,BRENDA,etha,CHEBI:16000,betaldhx
0.0001-0.0005 mM HgCl2,1.2.1.8,C00703,,33,390329,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,betaldhx
"1 mM, 24% inhibition",1.2.1.8,,,2750,390329,,-,,Escherichia coli,BRENDA,sarcs,CHEBI:57433,betaldhx
substrate inhibition above 10 mM,1.2.1.8,C00006,,10,390329,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,betaldhx
"1 mM, 54% inhibition",1.2.1.8,C00601,,769,390329,,-,Phenylacetaldehyde,Escherichia coli,BRENDA,pacald,CHEBI:16424,betaldhx
competitive inhibition,1.2.1.10,C00084,,90,724721,,-,Acetaldehyde,Escherichia coli,BRENDA,acald,CHEBI:15343,acald
,1.2.1.10,C13050,,402,390164,,-,Cyclic ADP-ribose,Escherichia coli,BRENDA,adprib,CHEBI:31445,acald
,1.2.1.10,C00020,,30,390164,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,acald
,1.2.1.11,C00067,,130,390180,,-,Formaldehyde,Escherichia coli,BRENDA,fald,CHEBI:16842,asad
oxidized glutathione,1.2.1.11,C00127,,330,654891,,-,Glutathione disulfide,Escherichia coli,BRENDA,gthox,CHEBI:17858,asad
,1.2.1.11,C00238,,39,390180,,-,Potassium cation,Escherichia coli,BRENDA,k,CHEBI:29103,asad
,1.2.1.11,C01330,,59,390180,,-,Sodium cation,Escherichia coli,BRENDA,na1,CHEBI:29101,asad
,1.2.1.11,,,1989,390200,,-,,Escherichia coli,BRENDA,tungs,CHEBI:36272,asad
"; 1 mM, isozyme A, 18% inhibition",1.2.1.21,C14818,,25,390215,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,gcaldd
substrate inhibition,1.2.1.21,C00266,,604,390213,,-,Glycolaldehyde,Escherichia coli,BRENDA,gcald,CHEBI:17071,gcaldd
substrate inhibition,1.2.1.21,C00160,,479,390213,,-,Glycolate,Escherichia coli,BRENDA,glyclt,CHEBI:17497,gcaldd
"1 mM, isozyme A, 20% inhibition, isozyme C, 44% inhibition",1.2.1.21,,,11,390215,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,gcaldd
"0.01 mM, 40% inhibition of total enzyme activity in cell extracts",1.2.1.21,C00250,,608,390214,,-,Pyridoxal,Escherichia coli,BRENDA,pydx,CHEBI:17310,gcaldd
"approx. 0.1 mM, 22% inhibition of isozyme A",1.2.1.21,C00534,,1284,390214,,-,Pyridoxamine,Escherichia coli,BRENDA,pydam,CHEBI:16410,gcaldd
"approx. 0.1 mM, 23% inhibition of isozyme A",1.2.1.21,C00647,,5608,390214,,-,Pyridoxamine phosphate,Escherichia coli,BRENDA,pyam5p,CHEBI:18335,gcaldd
"approx. 0.1 mM, 33% inhibition of isozyme C, 0.39 mM, 50% inhibition",1.2.1.21,C00314,,1051,390214,,-,Pyridoxine,Escherichia coli,BRENDA,pydxn,CHEBI:16709,gcaldd
"approx. 0.1 mM, 23% inhibition of isozyme C",1.2.1.21,C00627,,30371,390214,,-,Pyridoxine phosphate,Escherichia coli,BRENDA,pdx5p,CHEBI:28803,gcaldd
"1 mM, isozyme A, 30% inhibition",1.2.1.21,C00038,,14,390215,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,gcaldd
50% inhibition at 5 mM,1.2.1.22,C00076,,15,288133,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,lcadi
50% inhibition at 0.25 mM,1.2.1.22,,,19,288133,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,lcadi
85% inhibition at 0.1 mM,1.2.1.22,,,19,288135,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,lcadi
substrate inhibition,1.2.1.22,C00266,,604,288133,,-,Glycolaldehyde,Escherichia coli,BRENDA,gcald,CHEBI:17071,lcadi
substrate inhibition,1.2.1.22,C05999,,9202,288133,,-,Lactaldehyde,Escherichia coli,BRENDA,lald__l,CHEBI:18419,lcadi
substrate inhibition,1.2.1.22,C00546,,322,288133,,-,Methylglyoxal,Escherichia coli,BRENDA,mthgxl,CHEBI:17158,lcadi
56% inhibition at 10 mM,1.2.1.22,C00305,,6,670833,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,lcadi
,1.2.1.22,C00305,,6,695015,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,lcadi
50% inhibition at 10 mM,1.2.1.22,,,11,288133,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,lcadi
50% inhibition at 0.4 mM,1.2.1.22,C00038,,14,288133,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,lcadi
,1.2.1.38,,,19,390280,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,agpr
slight,1.2.1.38,C14818,,25,390280,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,agpr
slight,1.2.1.38,,,11,390280,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,agpr
slight,1.2.1.38,,,38,390280,,-,,Escherichia coli,BRENDA,ni2,CHEBI:49786,agpr
,1.2.1.38,C00038,,14,390280,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,agpr
50% inhibition at 2.5 mM,1.2.1.41,C00175,,23,390308,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,g5sd
75% inhibition at 0.1 mM,1.2.1.41,,,19,390308,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,g5sd
competitive with respect to all three substrates,1.2.1.41,C00005,,5,390307,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,g5sd
100% inhibition at 0.1 mM,1.2.1.41,,,38,390308,,-,,Escherichia coli,BRENDA,ni2,CHEBI:49786,g5sd
,1.2.1.70,C00175,,23,656104,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,glutrr
,1.2.1.70,,,38,656104,,-,,Escherichia coli,BRENDA,ni2,CHEBI:49786,glutrr
weak,1.2.4.1,C00084,,90,348956,,-,Acetaldehyde,Escherichia coli,BRENDA,acald,CHEBI:15343,pdh
reversed by CoA,1.2.4.1,C00024,,29,348914,,-,Acetyl-CoA,Escherichia coli,BRENDA,accoa,CHEBI:15351,pdh
,1.2.4.1,C00109,,29733,348956,,-,2-Oxobutanoate,Escherichia coli,BRENDA,2obut,CHEBI:30831,pdh
,1.2.4.1,C00168,,5529,348956,,-,Hydroxypyruvate,Escherichia coli,BRENDA,hpyr,CHEBI:30841,pdh
weak,1.2.4.1,C00048,,3343,348956,,-,Glyoxylate,Escherichia coli,BRENDA,glx,CHEBI:16891,pdh
weak,1.2.4.1,C00186,,403,348956,,-,(S)-Lactate,Escherichia coli,BRENDA,lac__l,CHEBI:422,pdh
,1.2.4.1,C00166,,198,348956,,-,Phenylpyruvate,Escherichia coli,BRENDA,phpyr,CHEBI:30851,pdh
,1.3.1.9,C00463,,472,696692,,-,Indole,Escherichia coli,BRENDA,indole,CHEBI:16881,ear121x
"50% inhibition at 0.0054 mM, competitive inhibition",1.3.1.9,,,128,390503,,-,,Escherichia coli,BRENDA,pmtcoa,CHEBI:57379,ear121x
"0.0016 mM lead to 50% inhibition, 0.002 mM to 60%, 0.005 mM to 20%, 0.01 mM to nearly total inhibition",1.3.1.10,,,128,390503,,-,,Escherichia coli,BRENDA,pmtcoa,CHEBI:57379,ear121y
"at high concentration, competitive with respect to NADPH",1.3.1.98,C00008,,13,286065,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,uapgr
"at high concentration, competitive with respect to NADPH",1.3.1.98,C13050,,402,286065,,-,Cyclic ADP-ribose,Escherichia coli,BRENDA,adprib,CHEBI:31445,uapgr
noncompetitive with respect to NADPH,1.3.1.98,C00006,,10,286065,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,uapgr
about 78% inhibition at 0.06 mM,1.3.1.98,C00006,,10,722831,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,uapgr
"substrate inhibition at pH 7.0, Ki: 1.6 mM",1.3.1.98,C00005,,5,286065,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,uapgr
"at high concentration, noncompetitive with respect to NADPH",1.3.1.98,C00015,,26,286065,,-,UDP,Escherichia coli,BRENDA,udp,CHEBI:17659,uapgr
"substrate inhibition at pH 6, Ki 0.01 mM with 0.15 mM NADPH, weaker at more basic pH",1.3.1.98,C04631,,7301,286065,,-,UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine,Escherichia coli,BRENDA,uaccg,CHEBI:68507,uapgr
"at very high concentration, noncompetitive with respect to NADPH",1.3.1.98,C00043,,97287,286065,,-,UDP-N-acetyl-alpha-D-glucosamine,Escherichia coli,BRENDA,uacgam,CHEBI:16264,uapgr
inhibition of HemF,1.3.3.3,C02191,,15936,656175,,-,Protoporphyrin,Escherichia coli,BRENDA,ppp9,CHEBI:15430,cpppgo
enzyme inactivation at 30%,1.3.99.22,,,22,711348,,-,,Escherichia coli,BRENDA,h2o2,CHEBI:29192,cpppgo2
inhibitory at higher concentrations than 1 mM,1.4.1.4,C00020,,30,391685,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,gludy
at 1 mM 27% inhibition,1.4.1.4,C00076,,15,391662,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,gludy
competitive inhibitor with respect to both ammonia and glutamine,1.4.1.4,,,345,391686,,-,,Escherichia coli,BRENDA,hom__l,CHEBI:57476,gludy
"at 10 mM, 90% inhibition, complete protection when 16.8 mM 2-oxoglutarate and 1.68 mM NADP+ are added",1.4.1.4,C00018,,32,391667,,-,Pyridoxal phosphate,Escherichia coli,BRENDA,pydx5p,CHEBI:18405,gludy
at 8 M stable for 10 min,1.4.1.4,,,116,391685,,-,,Escherichia coli,BRENDA,urea,CHEBI:32285,gludy
"at 1 mM, 40% inhibition",1.4.1.4,C00038,,14,391662,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,gludy
15% inhibition at 50 mM,1.4.1.13,C00008,,13,391438,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,glusy
19% inhibition at 25 mM and 43% inhibition at 50 mM,1.4.1.13,C00002,,4,391438,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,glusy
22% inhibition at 50 mM,1.4.1.13,C00417,,1230,391438,,-,cis-Aconitate,Escherichia coli,BRENDA,acon_c,CHEBI:32805,glusy
9% inhibition at 25 mM and 21% inhibition at 50 mM,1.4.1.13,,,60,391438,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,glusy
50% inhibition at concentrations below 7 mM,1.4.1.13,C00217,,344,391438,,-,D-Glutamate,Escherichia coli,BRENDA,glu__d,CHEBI:15966,glusy
19% inhibition at 50 mM,1.4.1.13,,,957,391438,,-,,Escherichia coli,BRENDA,met__d,CHEBI:57932,glusy
significant inhibitor,1.4.1.13,,,72,391438,,-,,Escherichia coli,BRENDA,gly,CHEBI:57305,glusy
16% inhibition at 25 mM and 43% inhibition at 50 mM,1.4.1.13,C00044,,37,391438,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,glusy
35% inhibition at 50 mM,1.4.1.13,C00311,,279,391438,,-,Isocitrate,Escherichia coli,BRENDA,icit,CHEBI:30887,glusy
17% inhibition at 25 mM and 29% inhibition at 50 mM,1.4.1.13,C00081,,229,391438,,-,ITP,Escherichia coli,BRENDA,itp,CHEBI:16039,glusy
significant inhibitor,1.4.1.13,,,103,391438,,-,,Escherichia coli,BRENDA,ala__l,CHEBI:57972,glusy
significant inhibitor,1.4.1.13,,,266,391438,,-,,Escherichia coli,BRENDA,asn__l,CHEBI:58048,glusy
50% inhibition at concentrations below 7 mM,1.4.1.13,C00049,,97,391438,,-,L-Aspartate,Escherichia coli,BRENDA,asp__l,CHEBI:17053,glusy
significant inhibitor,1.4.1.13,,,74,391438,,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,glusy
50% inhibition at concentrations between 17 and 35 mM,1.4.1.13,C00025,,41,391438,,-,L-Glutamate,Escherichia coli,BRENDA,glu__l,CHEBI:16015,glusy
"competitive inhibitor of the forward reaction with L-glutamine as the varied substrate, noncompetitive inhibitor with alpha-ketoglutarate as the varied substrate",1.4.1.13,C00025,,41,391442,,-,L-Glutamate,Escherichia coli,BRENDA,glu__l,CHEBI:16015,glusy
significant inhibitor,1.4.1.13,,,349,391438,,-,,Escherichia coli,BRENDA,his__l,CHEBI:57595,glusy
significant inhibitor,1.4.1.13,,,345,391438,,-,,Escherichia coli,BRENDA,hom__l,CHEBI:57476,glusy
19% inhibition at 50 mM,1.4.1.13,C00149,,247,391438,,-,(S)-Malate,Escherichia coli,BRENDA,mal__l,CHEBI:30797,glusy
50% inhibition at concentrations below 7 mM,1.4.1.13,C00073,,88,391438,,-,L-Methionine,Escherichia coli,BRENDA,met__l,CHEBI:16643,glusy
significant inhibitor,1.4.1.13,,,95,391438,,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,glusy
50% inhibition at concentrations below 7 mM,1.4.1.13,C00006,,10,391438,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,glusy
competitive vs. NADPH and noncompetitive vs. L-glutamine,1.4.1.13,C00006,,10,391442,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,glusy
"inactivation of glutamine-dependent activity, 50% inactivation at 0.36 mM in 10 min",1.4.1.13,C00005,,5,391457,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,glusy
,1.4.1.13,C00036,,57,391438,,-,Oxaloacetate,Escherichia coli,BRENDA,oaa,CHEBI:30744,glusy
20% inhibition at 50 mM,1.4.1.13,C00022,,31,391438,,-,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,glusy
16% inhibition at 50 mM,1.4.1.13,C00042,,58,391438,,-,Succinate,Escherichia coli,BRENDA,succ,CHEBI:15741,glusy
17% inhibition at 25 mM and 33% inhibition at 50 mM,1.4.1.13,C00075,,65,391438,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,glusy
competitive inhibition,1.4.3.5,C00018,,32,391903,,-,Pyridoxal phosphate,Escherichia coli,BRENDA,pydx5p,CHEBI:18405,pdx5poi
,1.4.3.5,C00018,,32,"391904, 654870",,-,Pyridoxal phosphate,Escherichia coli,BRENDA,pydx5p,CHEBI:18405,pdx5poi
competitive inhibitor,1.4.3.5,C00018,,32,724427,,-,Pyridoxal phosphate,Escherichia coli,BRENDA,pydx5p,CHEBI:18405,pdx5poi
substrate inhibition,1.4.3.5,C00627,,1037,654870,,-,Pyridoxine phosphate,Escherichia coli,BRENDA,pdx5p,CHEBI:28803,pdx5poi
substrate inactivation,1.4.3.16,C00049,,97,391756,,-,L-Aspartate,Escherichia coli,BRENDA,asp__l,CHEBI:17053,aspo6
competitive to FAD,1.4.3.16,C00003,,7,"391756, 391760",,-,NAD+,Escherichia coli,BRENDA,nad,CHEBI:15846,aspo6
,1.4.3.16,,,116,391756,,-,,Escherichia coli,BRENDA,urea,CHEBI:32285,aspo6
above 0.16 mM,1.5.1.2,C00004,,8,392126,,-,NADH,Escherichia coli,BRENDA,nadh,CHEBI:16908,p5cr
,1.5.1.2,C00006,,10,392126,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,p5cr
above 0.13 mM,1.5.1.2,C00005,,5,392126,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,p5cr
,1.5.1.2,,,1625,392126,,-,,Escherichia coli,BRENDA,pro__l,CHEBI:60039,p5cr
,1.5.1.3,C00076,,15,392238,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,dhfr
,1.5.1.3,C01327,,141,392241,,-,Hydrochloric acid,Escherichia coli,BRENDA,cl,CHEBI:17883,dhfr
12 mM,1.5.1.3,C00134,,16078,392238,,-,Putrescine,Escherichia coli,BRENDA,ptrc,CHEBI:17148,dhfr
12 mM,1.5.1.3,C01672,,45475,392238,,-,Cadaverine,Escherichia coli,BRENDA,15dap,CHEBI:18127,dhfr
,1.5.1.3,C00238,,39,"392228, 392238",,-,Potassium cation,Escherichia coli,BRENDA,k,CHEBI:29103,dhfr
,1.5.1.3,C00305,,6,392238,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,dhfr
,1.5.1.3,C01330,,59,"392228, 392238",,-,Sodium cation,Escherichia coli,BRENDA,na1,CHEBI:29101,dhfr
12 mM,1.5.1.3,C00315,,148,392238,,-,Spermidine,Escherichia coli,BRENDA,spmd,CHEBI:16610,dhfr
"3 M, 15% inhibition",1.5.1.3,,,116,392238,,-,,Escherichia coli,BRENDA,urea,CHEBI:32285,dhfr
,1.5.1.5,C00002,,4,"392307, 392308",,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,mthfd
,1.5.1.5,C00044,,37,"392307, 392308",,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,mthfd
,1.5.1.20,C00143,,401,696353,,-,"5,10-Methylenetetrahydrofolate",Escherichia coli,BRENDA,mlthf,CHEBI:1989,mthfr2
,1.5.1.20,,,934,654771,,-,,Escherichia coli,BRENDA,mlthf,CHEBI:20502,mthfr2
,1.5.1.20,C00004,,8,654771,,-,NADH,Escherichia coli,BRENDA,nadh,CHEBI:16908,mthfr2
slightly inhibitory,1.6.1.1,C00076,,15,725040,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,thd2pp
,1.6.1.1,C00175,,23,725040,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,thd2pp
,1.6.1.1,,,19,725040,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,thd2pp
slightly inhibitory,1.6.1.1,C11143,,896,725040,,-,Dimethyl sulfoxide,Escherichia coli,BRENDA,dmso,CHEBI:28262,thd2pp
,1.6.1.1,,,11,725040,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,thd2pp
"EcSTH activity is strongly inhibited by excess NADPH, but not by thio-NAD+",1.6.1.1,C00005,,5,725040,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,thd2pp
,1.6.1.1,,,38,725040,,-,,Escherichia coli,BRENDA,ni2,CHEBI:49786,thd2pp
,1.6.1.1,C00038,,14,725040,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,thd2pp
"10 mM, 24% inhibition",1.7.1.4,C06697,,397,392923,,-,Arsenite,Escherichia coli,BRENDA,aso3,CHEBI:49900,ntrir2x
"0.5 mM, 62% inhibition",1.7.1.4,C06697,,397,392929,,-,Arsenite,Escherichia coli,BRENDA,aso3,CHEBI:49900,ntrir2x
,1.7.1.4,C01326,,159,392923,,-,Hydrogen cyanide,Escherichia coli,BRENDA,cyan,CHEBI:18407,ntrir2x
"0.02 mM, 88% inhibition",1.7.1.4,C01326,,159,392929,,-,Hydrogen cyanide,Escherichia coli,BRENDA,cyan,CHEBI:18407,ntrir2x
"hydroxylamine reduction, substrate inhibition at low concentration, mixed inhibition vs. NADH",1.7.1.4,C00003,,7,392926,,-,NAD+,Escherichia coli,BRENDA,nad,CHEBI:15846,ntrir2x
"substrate inhibition at high concentration, required for full activity at low concentrations, maximum at 1 mM",1.7.1.4,C00003,,7,392928,,-,NAD+,Escherichia coli,BRENDA,nad,CHEBI:15846,ntrir2x
"0.06 mM, 13% inhibition, 0.27 mM, 43% inhibition",1.7.1.4,C00006,,10,392929,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,ntrir2x
"1 mM, 22% inhibition",1.7.1.4,C00094,,902,392923,,-,Sulfite,Escherichia coli,BRENDA,so3,CHEBI:48854,ntrir2x
weak,1.7.1.7,C00020,,30,394292,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,gmpr
,1.7.1.7,C00002,,4,394292,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,gmpr
,1.7.1.7,C00130,,232,394292,,-,IMP,Escherichia coli,BRENDA,imp,CHEBI:17202,gmpr
"reduced enzyme is more sensitive at pH 7.2 than at pH 10.5, at pH 10.5 reversible enzyme-cyanide complexes are formed with reduced enzyme, nitrate protects reduced enzyme for inactivation, oxidized enzyme is less sensitive, kinetics of inactivation",1.7.99.4,C01326,,118,395167,,-,Hydrogen cyanide,Escherichia coli,BRENDA,cyan,CHEBI:18407,no3r2bpp
inactivates in absence of cyanide,1.7.99.4,,,318,395167,,-,,Escherichia coli,BRENDA,h2s,CHEBI:29919,no3r2bpp
,1.8.1.2,C06697,,397,"348059, 392964, 392968",,-,Arsenite,Escherichia coli,BRENDA,aso3,CHEBI:49900,sulri
strong inhibition,1.8.1.2,C00076,,15,656421,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,sulri
,1.8.1.2,C01413,,52,656421,,-,Cadmium,Escherichia coli,BRENDA,cd2,CHEBI:48775,sulri
,1.8.1.2,C01327,,141,392964,,-,Hydrochloric acid,Escherichia coli,BRENDA,cl,CHEBI:17883,sulri
,1.8.1.2,C01326,,159,"348059, 392958, 392964, 392967, 392968",,-,Hydrogen cyanide,Escherichia coli,BRENDA,cyan,CHEBI:18407,sulri
strong inhibition,1.8.1.2,C00175,,23,656421,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,sulri
strong inhibition,1.8.1.2,,,19,656421,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,sulri
strong inhibition,1.8.1.2,C14818,,25,656421,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,sulri
strong inhibition,1.8.1.2,C14819,,70,656421,,-,Fe3+,Escherichia coli,BRENDA,fe3,CHEBI:29034,sulri
strong inhibition,1.8.1.2,C00703,,33,656421,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,sulri
,1.8.1.2,,,11,656421,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,sulri
NADPH-dependent activities,1.8.1.2,C00006,,10,"392964, 392968",,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,sulri
,1.8.1.2,,,673,392964,,-,,Escherichia coli,BRENDA,no3,CHEBI:17632,sulri
,1.8.1.2,C00059,,160,392964,,-,Sulfate,Escherichia coli,BRENDA,so4,CHEBI:26836,sulri
"reduction of sulfite, nitrite, hydroxylamine by reduced methyl viologen",1.8.1.2,,,318,348059,,-,,Escherichia coli,BRENDA,h2s,CHEBI:29919,sulri
,1.8.1.2,C00038,,14,656421,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,sulri
,1.8.1.9,C06697,,397,394931,,-,Arsenite,Escherichia coli,BRENDA,aso3,CHEBI:49900,trdr
,1.8.1.9,C00076,,15,"394908, 394952",,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,trdr
product inhibition,1.8.1.9,C00006,,10,393993,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,trdr
competitive with respect to 5-phosphoadenosine 3-phosphosulfate,1.8.4.8,C00054,,68,133778,,-,"Adenosine 3',5'-bisphosphate",Escherichia coli,BRENDA,pap,CHEBI:17985,papsr
"reversible inhibition, forms mixed disulfides with the enzymes active site residue Cys239, inactivation kinetics, inhibition is reversible by glutaredoxin, not by DTT, glutaredoxin together with glutathione exhibits regulatory function in vivo",1.8.4.8,C00127,,1794,659214,,-,Glutathione disulfide,Escherichia coli,BRENDA,gthox,CHEBI:17858,papsr
inactivation half-life: 20-30 min at 2 mM,1.11.1.6,,,22,439792,,-,,Escherichia coli,BRENDA,h2o2,CHEBI:29192,cat
"excess H2O2 inhibits the enzyme. In the presence of excess H2O2, [FeII/FeII]-ADEec rapidly loses its ability to deaminate adenine",1.11.1.6,,,22,726446,,-,,Escherichia coli,BRENDA,h2o2,CHEBI:29192,cat
,1.13.11.16,,,22,395595,,-,,Escherichia coli,BRENDA,h2o2,CHEBI:29192,dhcindo
inhibits activity by 80-95% at 0.01-0.05 mM,1.14.11.17,C00175,,23,285263,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,taudo
"IC50: 0.0019 mM, in the presence of Fe2+; IC50: 0.041 mM",1.14.11.17,C00175,,23,671717,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,taudo
inhibits activity by 80-95% at 0.01-0.05 mM,1.14.11.17,,,19,285263,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,taudo
"IC50: 0.00071 mM, in the presence of Fe2+; IC50: 0.032 mM",1.14.11.17,,,38,671717,,-,,Escherichia coli,BRENDA,ni2,CHEBI:49786,taudo
inhibits activity by 80-95% at 0.01-0.05 mM,1.14.11.17,C00038,,14,285263,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,taudo
"high concentrations, competition with O2, augmented by miconazole",1.14.12.17,C00533,,277,657560,,-,Nitric oxide,Escherichia coli,BRENDA,no,CHEBI:16480,nodox
"Cu,Zn-SOD; no inhibition: Mn-SOD",1.15.1.1,,,22,438096,,-,,Escherichia coli,BRENDA,h2o2,CHEBI:29192,spodm
"substrate analogue, formation of a green complex upon binding",1.15.1.1,,,5554,672026,,-,,Escherichia coli,BRENDA,h2s,CHEBI:29919,spodm
50 Zn2+ ions per bacterioferritin blocked binding of Fe2+,1.16.3.1,C00038,,14,696359,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,feropp
inhibitory,1.17.1.2,C00076,,15,661928,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,dmpps
"weak inhibition of the enzyme, when FAD is used as reducing cofactor",1.17.1.2,C00175,,23,639341,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,dmpps
inhibitory,1.17.1.2,C00175,,23,661928,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,dmpps
inhibitory,1.17.1.2,C14818,,25,661928,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,dmpps
inhibitory,1.17.1.2,C00305,,6,661928,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,dmpps
inhibitory,1.17.1.2,,,11,661928,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,dmpps
inhibitory,1.17.1.2,,,38,661928,,-,,Escherichia coli,BRENDA,ni2,CHEBI:49786,dmpps
complete inhibition,1.17.1.2,C00038,,14,661928,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,dmpps
competitive inhibition of UDP reduction,1.17.4.1,C00112,,212,437938,,-,CDP,Escherichia coli,BRENDA,cdp,CHEBI:17239,rndr1
RNR activity chelates with copper leading to inactivation,1.17.4.1,C00175,,23,715085,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,rndr1
inhibition of ADP reduction; inhibition of CDP reduction; inhibition of GDP reduction,1.17.4.1,C00131,,140,437937,,-,dATP,Escherichia coli,BRENDA,datp,CHEBI:16284,rndr1
inhibition of CDP reduction; inhibition of UDP reduction,1.17.4.1,C00131,,140,437938,,-,dATP,Escherichia coli,BRENDA,datp,CHEBI:16284,rndr1
inhibition of CDP and UDP reduction is reversed by ATP; inhibition of CDP reduction; inhibition of UDP reduction,1.17.4.1,C00131,,140,437939,,-,dATP,Escherichia coli,BRENDA,datp,CHEBI:16284,rndr1
inhibition by dATP has a regulatory function,1.17.4.1,C00131,,140,716317,,-,dATP,Escherichia coli,BRENDA,datp,CHEBI:16284,rndr1
,1.17.4.1,C00286,,219,437937,,-,dGTP,Escherichia coli,BRENDA,dgtp,CHEBI:16497,rndr1
inhibition of ADP reduction,1.17.4.1,,,145,437937,,-,,Escherichia coli,BRENDA,dttp,CHEBI:37568,rndr1
"10 mM, 43% inhibition",1.17.4.1,C01563,,108977,437909,,-,Carbamate,Escherichia coli,BRENDA,cbm,CHEBI:28616,rndr1
,1.17.4.1,C00035,,53,437939,,-,GDP,Escherichia coli,BRENDA,gdp,CHEBI:17552,rndr1
competitive inhibition of CDP reduction,1.17.4.1,C00015,,26,437938,,-,UDP,Escherichia coli,BRENDA,udp,CHEBI:17659,rndr1
,1.17.4.1,C00015,,26,437939,,-,UDP,Escherichia coli,BRENDA,udp,CHEBI:17659,rndr1
product inhibition,2.1.1.10,C00073,,88,441382,,-,L-Methionine,Escherichia coli,BRENDA,met__l,CHEBI:16643,hcysmt
product inhibition above 0.5 mM,2.1.1.10,C00073,,88,692948,,-,L-Methionine,Escherichia coli,BRENDA,met__l,CHEBI:16643,hcysmt
product inhibition,2.1.1.10,,,36,441382,,-,,Escherichia coli,BRENDA,ahcys,CHEBI:57856,hcysmt
product inhibition above 0.25 mM,2.1.1.10,C00019,,24,692948,,-,S-Adenosyl-L-methionine,Escherichia coli,BRENDA,amet,CHEBI:15414,hcysmt
,2.1.1.45,C00143,,401,485397,,-,"5,10-Methylenetetrahydrofolate",Escherichia coli,BRENDA,mlthf,CHEBI:1989,tmds
,2.1.1.45,C00415,,1351,"485358, 485415",,-,Dihydrofolate,Escherichia coli,BRENDA,dhf,CHEBI:15633,tmds
,2.1.1.45,C00025,,297,485375,,-,L-Glutamate,Escherichia coli,BRENDA,glu__l,CHEBI:16015,tmds
,2.1.1.45,C00116,,135,485431,,-,Glycerol,Escherichia coli,BRENDA,glyc,CHEBI:17754,tmds
,2.1.1.45,,,2687,"485358, 485363, 485415",,-,,Escherichia coli,BRENDA,dtmp,CHEBI:46960,tmds
product inhibition,2.1.1.79,,,843,485627,,-,,Escherichia coli,BRENDA,ahcys,CHEBI:57856,cfas160e
,2.1.1.79,,,843,"485626, 485631",,-,,Escherichia coli,BRENDA,ahcys,CHEBI:57856,cfas160e
"0.5-1 mM, when cis-aconitate is used as substrate",2.1.1.144,C02341,,2874,288664,,-,trans-Aconitate,Escherichia coli,BRENDA,acon_t,CHEBI:32806,aconmt
inactivates enzyme by converting the enzyme bound pyridoxal 5'-phosphate to pyridoxamine phosphate in a transamination reaction,2.1.2.1,,,164,"441412, 441424",,-,,Escherichia coli,BRENDA,ala__d,CHEBI:57416,ghmt2r
"in 1 M urea, almost all the cofactor is bound to the enzyme as internal aldimine, indicating that the loss of activity does not result from the denaturation of the active site, these observations suggest that urea might act as an enzyme inhibitor",2.1.2.1,,,116,703674,,-,,Escherichia coli,BRENDA,urea,CHEBI:32285,ghmt2r
above 1 mM,2.1.2.11,C00010,,534,"485700, 485701",,-,CoA,Escherichia coli,BRENDA,coa,CHEBI:15346,mohmt
"0.8 mM, partial inhibition",2.1.2.11,C00067,,130,485700,,-,Formaldehyde,Escherichia coli,BRENDA,fald,CHEBI:16842,mohmt
"0.8 mM, partial inhibition; forward reaction",2.1.2.11,C00067,,130,485701,,-,Formaldehyde,Escherichia coli,BRENDA,fald,CHEBI:16842,mohmt
"5 mM, 23% inhibition",2.1.2.11,,,246,485700,,-,,Escherichia coli,BRENDA,val__l,CHEBI:57762,mohmt
0.05 mM or above,2.1.2.11,C00522,,2576,"485700, 485701",,-,(R)-Pantoate,Escherichia coli,BRENDA,pant__r,CHEBI:14737,mohmt
0.5 mM or above,2.1.2.11,C00864,,1509,"485700, 485701",,-,Pantothenate,Escherichia coli,BRENDA,pnto__r,CHEBI:46905,mohmt
"5 mM, 38% inhibition",2.1.2.11,C00022,,31,485700,,-,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,mohmt
"0.38 mM, partial inhibition",2.1.2.11,C00101,,207,485700,,-,Tetrahydrofolate,Escherichia coli,BRENDA,thf,CHEBI:15635,mohmt
"0.38 mM, partial inhibition; forward reaction",2.1.2.11,C00101,,207,485701,,-,Tetrahydrofolate,Escherichia coli,BRENDA,thf,CHEBI:15635,mohmt
,2.1.3.2,C00033,,47,485853,,-,Acetate,Escherichia coli,BRENDA,ac,CHEBI:15366,aspct
,2.1.3.2,C00049,,724,485841,,-,L-Aspartate,Escherichia coli,BRENDA,asp__l,CHEBI:17053,aspct
,2.1.3.2,C01327,,141,485853,,-,Hydrochloric acid,Escherichia coli,BRENDA,cl,CHEBI:17883,aspct
800-1000 mM urea lower or eliminate CTP inhibition,2.1.3.2,,,60,485837,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,aspct
,2.1.3.2,,,60,"485838, 485839",,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,aspct
competitive vs. carbamoyl phosphate,2.1.3.2,,,60,485841,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,aspct
synergistic inhibition by CTP and UTP,2.1.3.2,,,60,"485840, 485842",,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,aspct
"CTP inhibits ATCase activity. Experimentally driven, statistical modeling approach (high-dimensional model representation, RS-HDMR) to investigate regulation of ATCase in response to varying concentrations of its nucleotide regulators ATP, CTP, GTP, and UTP (at fixed substrate concentrations)",2.1.3.2,,,60,685252,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,aspct
addition of CTP or the combination of CTP/UTP to the substrates significantly decreases the rate of the low activity-high activity T-R transition and causes a shift in the enzymepopulation towards the T state even at saturating substrate concentrations,2.1.3.2,,,60,699559,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,aspct
ATCase is feedback inhibited by CTP and synergistically by the combination of CTP plus UTP,2.1.3.2,,,60,718458,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,aspct
"aspartate transcarbamoylase is feedback inhibited by CTP in the presence of CTP. CTP and UTP do not bind competitively, CTP binding structure, overview",2.1.3.2,,,60,718936,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,aspct
"demetaled CTP, synergistic inhibition with UTP, while UTP alone has little or no influence on the enzyme activity, mechanism, overview. Binding of UTP can enhance the binding of CTP and presence of a metal ion such as Mg2+ is required for synergistic inhibition. Structure of the ATCase-CTP-UTP-Mg2+ complex",2.1.3.2,,,60,718943,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,aspct
,2.1.3.2,C00475,,372,485837,,-,Cytidine,Escherichia coli,BRENDA,cytd,CHEBI:17562,aspct
,2.1.3.2,C00458,,179,718943,,-,dCTP,Escherichia coli,BRENDA,dctp,CHEBI:16311,aspct
,2.1.3.2,C00013,,17,"485837, 485843",,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,aspct
,2.1.3.2,C00122,,170,485853,,-,Fumarate,Escherichia coli,BRENDA,fum,CHEBI:18012,aspct
,2.1.3.2,C00044,,37,485837,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,aspct
"GTP inhibits ATCase activity. Experimentally driven, statistical modeling approach (high-dimensional model representation, RS-HDMR) to investigate regulation of ATCase in response to varying concentrations of its nucleotide regulators ATP, CTP, GTP, and UTP (at fixed substrate concentrations)",2.1.3.2,C00044,,37,685252,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,aspct
,2.1.3.2,C00294,,167,485837,,-,Inosine,Escherichia coli,BRENDA,ins,CHEBI:17596,aspct
weak inhibition,2.1.3.2,C00081,,229,485837,,-,ITP,Escherichia coli,BRENDA,itp,CHEBI:16039,aspct
,2.1.3.2,C00049,,97,485841,,-,L-Aspartate,Escherichia coli,BRENDA,asp__l,CHEBI:17053,aspct
,2.1.3.2,C00149,,247,485853,,-,(S)-Malate,Escherichia coli,BRENDA,mal__l,CHEBI:30797,aspct
,2.1.3.2,C00042,,58,485853,,-,Succinate,Escherichia coli,BRENDA,succ,CHEBI:15741,aspct
weak inhibition,2.1.3.2,C00075,,65,485837,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,aspct
,2.1.3.2,C00075,,65,485839,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,aspct
"synergistic inhibition by CTP and UTP, no inhibition unless CTP is present",2.1.3.2,C00075,,65,"485840, 485842",,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,aspct
"UTP inhibits ATCase activity. Experimentally driven, statistical modeling approach (high-dimensional model representation, RS-HDMR) to investigate regulation of ATCase in response to varying concentrations of its nucleotide regulators ATP, CTP, GTP, and UTP (at fixed substrate concentrations)",2.1.3.2,C00075,,65,685252,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,aspct
addition of CTP or the combination of CTP/UTP to the substrates significantly decreases the rate of the low activity-high activity T-R transition and causes a shift in the enzymepopulation towards the T state even at saturating substrate concentrations,2.1.3.2,C00075,,65,699559,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,aspct
"aspartate transcarbamoylase is feedback inhibited by UTP in the presence of CTP. UTP binds to a unique site on each regulatory chain of the enzyme that is near but not overlapping with the known CTP site. CTP and UTP do not bind competitively, UTP binds to the r6 regulatory chain of ATCase, UTP binding structure, overview",2.1.3.2,C00075,,65,718936,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,aspct
"inhibition with CTP, while UTP alone has little or no influence on the enzyme activity, mechanism, overview. UTP, in the presence of dCTP or CTP, binds at a site on a regulatory side chain that does not overlap the CTP/dCTP site, and the triphosphates of the two nucleotides are parallel to each other with a metal ion, in this case Mg2+, coordinated between the beta- and gamma-phosphates of the two nucleotides. UTP binds more tightly in the presence of CTP. Structure of the ATCase-CTP-UTP-Mg2+ complex",2.1.3.2,C00075,,65,718943,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,aspct
"competitive vs. carbamoylphosphate, noncompetitive vs. ornithine",2.1.3.3,C01478,,255,485898,,-,Arsenic acid,Escherichia coli,BRENDA,aso4,CHEBI:18231,ocbt
,2.1.3.3,,,72,485898,,-,,Escherichia coli,BRENDA,gly,CHEBI:57305,ocbt
,2.1.3.3,,,103,485898,,-,,Escherichia coli,BRENDA,ala__l,CHEBI:57972,ocbt
weak,2.1.3.3,,,266,485898,,-,,Escherichia coli,BRENDA,asn__l,CHEBI:58048,ocbt
,2.1.3.3,,,311,485898,,-,,Escherichia coli,BRENDA,ile__l,CHEBI:58045,ocbt
,2.1.3.3,,,127,485898,,-,,Escherichia coli,BRENDA,leu__l,CHEBI:57427,ocbt
weak,2.1.3.3,C00047,,134,485898,,-,L-Lysine,Escherichia coli,BRENDA,lys__l,CHEBI:18019,ocbt
weak,2.1.3.3,,,95,485898,,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,ocbt
,2.1.3.3,,,246,485898,,-,,Escherichia coli,BRENDA,val__l,CHEBI:57762,ocbt
L-isomer,2.1.3.3,,,692,485898,,-,,Escherichia coli,BRENDA,met__l,CHEBI:57844,ocbt
at high concentrations; noncompetitive substrate inhibition vs. carbamoylphosphate,2.1.3.3,C00077,,576,485898,,-,L-Ornithine,Escherichia coli,BRENDA,orn,CHEBI:15729,ocbt
"competitive vs. carbamoylphosphate, noncompetitive vs. ornithine",2.1.3.3,C00009,,16,485898,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,ocbt
competitive inhibition,2.2.1.1,C01112,,538,486023,,-,D-Arabinose 5-phosphate,Escherichia coli,BRENDA,ara5p,CHEBI:16241,tkt1
"denaturation of holo-transketolase by urea displays at least three transitions, where only the final equilibrium denaturation transition is the same for both apo-transketolase and holo-transketolase. Enzyme is deactivated initially by changes in structure associated with the cofactors, but this event does not release the cofactor from the enzyme. Holo-transketolase does not denature to apo-transketolase at 2 M urea. Complete dissociation of cofactors from holo-transketolase at 3.8 M urea without formation of the compact form of apo-transketolase (intermediate form). Holo-transketolase and apo-transketolase at 7.2 M urea both show a common denatured form",2.2.1.1,,,116,692117,,-,,Escherichia coli,BRENDA,urea,CHEBI:32285,tkt1
,2.2.1.2,C01112,,15695,486041,,-,D-Arabinose 5-phosphate,Escherichia coli,BRENDA,ara5p,CHEBI:16241,tala
,2.2.1.2,C00937,,4237,719298,,-,(R)-Lactaldehyde,Escherichia coli,BRENDA,lald__d,CHEBI:17167,tala
,2.2.1.2,C00013,,17,486027,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,tala
,2.2.1.2,C00009,,16,"486027, 486041",,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,tala
,2.2.1.2,C00059,,160,486027,,-,Sulfate,Escherichia coli,BRENDA,so4,CHEBI:26836,tala
isoenzyme I has lower sensitivity to inhibition than isoenzyme III,2.2.1.6,C00109,,390,395887,,-,2-Oxobutanoate,Escherichia coli,BRENDA,2obut,CHEBI:30831,achbs
isozyme AHAS II,2.2.1.6,C00048,,101,671290,,-,Glyoxylate,Escherichia coli,BRENDA,glx,CHEBI:16891,achbs
"progressive inactivation of enzyme with kinetics of suicide inhibition, mechanism",2.2.1.6,C00168,,389,659590,,-,Hydroxypyruvate,Escherichia coli,BRENDA,hpyr,CHEBI:30841,achbs
mild inhibition of isoenzyme I and III,2.2.1.6,,,1088,395884,,-,,Escherichia coli,BRENDA,ile__l,CHEBI:58045,achbs
"isoenzyme AHS I is sensitive to feed-back inhibition, isoenzyme AHS II is insensitive",2.2.1.6,,,1088,395900,,-,,Escherichia coli,BRENDA,ile__l,CHEBI:58045,achbs
"mixed noncompetitive inhibition of isoenzyme, pH-independent inhibition of isoenzyme III",2.2.1.6,,,421,395882,,-,,Escherichia coli,BRENDA,leu__l,CHEBI:57427,achbs
no inhibition of isoenzyme I and III,2.2.1.6,,,421,395884,,-,,Escherichia coli,BRENDA,leu__l,CHEBI:57427,achbs
"isoenzyme AHS I is sensitive to feed-back inhibition, isoenzyme AHS II is insensitive",2.2.1.6,,,421,395900,,-,,Escherichia coli,BRENDA,leu__l,CHEBI:57427,achbs
feedback inhibition,2.2.1.6,,,641,700782,,-,,Escherichia coli,BRENDA,leu__l,CHEBI:57427,achbs
"isoenzymes I and II are inhibited, isoenzyme II is not inhibited",2.2.1.6,,,1079,395884,,-,,Escherichia coli,BRENDA,val__l,CHEBI:57762,achbs
isoenzyme I and III inhibited,2.2.1.6,,,1079,395885,,-,,Escherichia coli,BRENDA,val__l,CHEBI:57762,achbs
isoenzyme I is more resistant to inhibition than isoenzyme III,2.2.1.6,,,1079,395887,,-,,Escherichia coli,BRENDA,val__l,CHEBI:57762,achbs
"isoenzyme AHS I is sensitive to feed-back inhibition, isoenzyme AHS II is insensitive",2.2.1.6,,,1079,395900,,-,,Escherichia coli,BRENDA,val__l,CHEBI:57762,achbs
"isozyme AHAS I, feedback inhibition",2.2.1.6,,,1210,671290,,-,,Escherichia coli,BRENDA,val__l,CHEBI:57762,achbs
"isozyme AHAS I, cooperative feedback inhibition",2.2.1.6,,,1210,672368,,-,,Escherichia coli,BRENDA,val__l,CHEBI:57762,achbs
"binding site structure, inhibition mechanism",2.2.1.6,,,1210,675377,,-,,Escherichia coli,BRENDA,val__l,CHEBI:57762,achbs
feedback inhibition,2.2.1.6,,,1210,700782,,-,,Escherichia coli,BRENDA,val__l,CHEBI:57762,achbs
competitive inhibition with respect to pyruvate,2.2.1.7,C00577,,639,719975,,-,D-Glyceraldehyde,Escherichia coli,BRENDA,glyald,CHEBI:17378,dxps
substrate inhibition,2.2.1.7,C00118,,147,719975,,-,D-Glyceraldehyde 3-phosphate,Escherichia coli,BRENDA,g3p,CHEBI:29052,dxps
substrate inhibition,2.2.1.7,C00022,,31,719975,,-,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,dxps
"0.02 mM, 50% inhibition; L-arginine",2.3.1.1,C00062,,532,"486063, 486066",,-,L-Arginine,Escherichia coli,BRENDA,arg__l,CHEBI:16467,acgs
,2.3.1.1,C00062,,532,685805,,-,L-Arginine,Escherichia coli,BRENDA,arg__l,CHEBI:16467,acgs
"0.1 mM, 94% inhibition",2.3.1.1,C01413,,52,486063,,-,Cadmium,Escherichia coli,BRENDA,cd2,CHEBI:48775,acgs
"2.5 mM, 50% inhibition",2.3.1.1,C00010,,534,"486061, 486063",,-,CoA,Escherichia coli,BRENDA,coa,CHEBI:15346,acgs
"0.1 mM, 68% inhibition",2.3.1.1,,,19,486063,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,acgs
0.1 mM; 50% inhibition,2.3.1.1,C00703,,33,486063,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,acgs
"10 mM, 75% inhibition",2.3.1.1,,,938,486063,,-,,Escherichia coli,BRENDA,citr__l,CHEBI:57743,acgs
,2.3.1.1,C00624,,3480,486061,,-,N-Acetyl-L-glutamate,Escherichia coli,BRENDA,acglu,CHEBI:17533,acgs
"25 mM, 50% inhibition",2.3.1.1,C00624,,3480,486063,,-,N-Acetyl-L-glutamate,Escherichia coli,BRENDA,acglu,CHEBI:17533,acgs
"0.1 mM, 43% inhibition",2.3.1.1,C00038,,14,486063,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,acgs
substrate inhibition above 0.105 mM,2.3.1.9,C00332,,187,487690,,-,Acetoacetyl-CoA,Escherichia coli,BRENDA,aacoa,CHEBI:15345,acact1r
in the absence of NaCl,2.3.1.15,C00076,,15,486357,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,g3pat120
in the absence of NaCl,2.3.1.15,C00305,,6,486357,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,g3pat120
"0.31 mM, 50% inhibition, synergism with cis-9,10-methylenehexadecanoic acid",2.3.1.15,C00712,,488,486365,,-,(9Z)-Octadecenoic acid,Escherichia coli,BRENDA,ocdcea,CHEBI:16196,g3pat120
"0.31 mM, 50% inhibition, synergism with cis-9,10-methylenehexadecanoic acid",2.3.1.15,C08362,,5594,486365,,-,(9Z)-Hexadecenoic acid,Escherichia coli,BRENDA,hdcea,CHEBI:28716,g3pat120
,2.3.1.15,,,128,486357,,-,,Escherichia coli,BRENDA,pmtcoa,CHEBI:57379,g3pat120
,2.3.1.15,C00009,,16,486381,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,g3pat120
mixed non-competitive with respect to serine,2.3.1.30,C00002,,4,657835,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,serat
,2.3.1.30,C00010,,18,486778,,-,CoA,Escherichia coli,BRENDA,coa,CHEBI:15346,serat
"competitive versus acetyl-CoA, mixed non-competitive with respect to serine",2.3.1.30,,,153,657835,,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,serat
"competitive, binds at the serine substrate site, negatively regulates its own synthesis",2.3.1.30,,,153,659391,,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,serat
"competitive against L-serine, noncompetitive against acetyl-CoA",2.3.1.30,,,72,486778,,-,,Escherichia coli,BRENDA,gly,CHEBI:57305,serat
mixed non-competitive inhibitor of propionyl transfer to serine with respect to propionyl-CoA,2.3.1.30,,,72,657835,,-,,Escherichia coli,BRENDA,gly,CHEBI:57305,serat
noncompetitive against acetyl-CoA,2.3.1.30,,,103,486778,,-,,Escherichia coli,BRENDA,ala__l,CHEBI:57972,serat
,2.3.1.30,,,336,676935,,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,serat
,2.3.1.30,,,74,"486752, 486756, 486757, 486777",,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,serat
"above 3 mM, weak",2.3.1.30,,,95,486752,,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,serat
,2.3.1.41,C00024,,29,486914,,-,Acetyl-CoA,Escherichia coli,BRENDA,accoa,CHEBI:15351,3oas121
"about 50% inhibition at 1 M, complete inactivation at 4 M",2.3.1.41,,,116,486918,,-,,Escherichia coli,BRENDA,urea,CHEBI:32285,3oas121
slight feed-back inhibition,2.3.1.46,,,957,487045,,-,,Escherichia coli,BRENDA,met__d,CHEBI:57932,hsst
feed-back inhibition,2.3.1.46,C00073,,88,"487044, 487045",,-,L-Methionine,Escherichia coli,BRENDA,met__l,CHEBI:16643,hsst
feedback inhibition,2.3.1.46,C00073,,88,671413,,-,L-Methionine,Escherichia coli,BRENDA,met__l,CHEBI:16643,hsst
feed-back inhibition,2.3.1.46,C00019,,24,487044,,-,S-Adenosyl-L-methionine,Escherichia coli,BRENDA,amet,CHEBI:15414,hsst
feedback inhibition,2.3.1.46,C00019,,24,671413,,-,S-Adenosyl-L-methionine,Escherichia coli,BRENDA,amet,CHEBI:15414,hsst
product inhibition in vivo,2.3.1.47,,,1494,487047,,-,,Escherichia coli,BRENDA,8aonn,CHEBI:57532,aoxsr2
,2.3.1.47,,,74,"487047, 487051",,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,aoxsr2
,2.3.1.54,,,32877,487236,,-,,Escherichia coli,BRENDA,o2,CHEBI:27140,obtfl
product inhibition,2.3.1.54,C00058,,120,487220,,-,Formate,Escherichia coli,BRENDA,for,CHEBI:30751,obtfl
,2.3.1.54,,,36,"487219, 487221",,-,,Escherichia coli,BRENDA,ahcys,CHEBI:57856,obtfl
product inhibition,2.3.1.79,C00010,,5141,487511,,-,CoA,Escherichia coli,BRENDA,coa,CHEBI:15346,maltatr
competitive versus TAMRA peptide,2.3.1.129,C04738,,87729,720069,,-,UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine,Escherichia coli,BRENDA,u3aga,CHEBI:61537,uagaat
competitive versus TAMRA peptide,2.3.1.129,C00043,,383,720069,,-,UDP-N-acetyl-alpha-D-glucosamine,Escherichia coli,BRENDA,uacgam,CHEBI:16264,uagaat
acetyltransferase activity inhibited by its reaction product,2.3.1.157,C04501,,31976,288685,,-,N-Acetyl-alpha-D-glucosamine 1-phosphate,Escherichia coli,BRENDA,acgam1p,CHEBI:16446,g1pact
"1 mM, relative enzyme activity 2%",2.3.1.157,C01050,,49468,288685,,-,UDP-N-acetylmuramate,Escherichia coli,BRENDA,uamr,CHEBI:70765,g1pact
,2.3.1.180,C10438,,864,719087,,-,Cinnamic acid,Escherichia coli,BRENDA,cinnm,CHEBI:27386,kas15
inhibition is overcome by the addition of excess (3R)-3-hydroxymyristoyl-[acyl-carrier protein],2.3.1.191,C00076,,15,696264,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,u23gaat
,2.3.1.191,C00305,,6,696264,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,u23gaat
functions as acyl donor at low concentration with inhibition of acylation at higher concentrations,2.3.1.241,C05274,,541,726949,,-,Decanoyl-CoA,Escherichia coli,BRENDA,dcacoa,CHEBI:28493,edtxs1
"i.e. myristoyl-CoA, functions as acyl donor at low concentration with inhibition of acylation at higher concentrations",2.3.1.241,C02593,,1053,726949,,-,Tetradecanoyl-CoA,Escherichia coli,BRENDA,tdcoa,CHEBI:15532,edtxs1
; competitive,2.3.3.9,C00209,,185,706621,,-,Oxalate,Escherichia coli,BRENDA,oxa,CHEBI:16995,mals
,2.3.3.9,C00022,,31,660456,,-,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,mals
; competitive,2.3.3.9,C00022,,31,706621,,-,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,mals
,2.3.3.16,C00026,,34,488040,,-,2-Oxoglutarate,Escherichia coli,BRENDA,akg,CHEBI:30915,cs
allosteric,2.3.3.16,C00004,,8,"488040, 488069",,-,NADH,Escherichia coli,BRENDA,nadh,CHEBI:16908,cs
"allosteric; CS II, strong and specific allosteric inhibition",2.3.3.16,C00004,,8,488085,,-,NADH,Escherichia coli,BRENDA,nadh,CHEBI:16908,cs
,2.3.3.16,C00036,,57,659254,,-,Oxaloacetate,Escherichia coli,BRENDA,oaa,CHEBI:30744,cs
competitive inhibition,2.4.1.1,C00498,,1112,488238,,-,ADP-glucose,Escherichia coli,BRENDA,adpglc,CHEBI:15751,glcp2
strong inhibition,2.4.1.1,,,75,488238,,-,,Escherichia coli,BRENDA,ag,CHEBI:49468,glcp2
,2.4.1.1,C01478,,255,488294,,-,Arsenic acid,Escherichia coli,BRENDA,aso4,CHEBI:18231,glcp2
weak,2.4.1.1,C00076,,15,488238,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,glcp2
,2.4.1.1,C01326,,159,488238,,-,Hydrogen cyanide,Escherichia coli,BRENDA,cyan,CHEBI:18407,glcp2
"1 mM, strong inhibition",2.4.1.1,,,19,488238,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,glcp2
non-competitive,2.4.1.1,C00031,,35,488238,,-,D-Glucose,Escherichia coli,BRENDA,glc__d,CHEBI:4167,glcp2
weak inhibition,2.4.1.1,C14818,,25,488238,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,glcp2
above 2 mM; substrate inhibition,2.4.1.1,,,464,488238,,-,,Escherichia coli,BRENDA,g1p,CHEBI:16077,glcp2
"1 mM, strong inhibition",2.4.1.1,C00703,,33,488238,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,glcp2
competitive inhibition,2.4.1.1,C00842,,7290,488238,,-,dTDP-glucose,Escherichia coli,BRENDA,dtdpglu,CHEBI:15700,glcp2
,2.4.1.1,C00029,,186,488238,,-,UDP-glucose,Escherichia coli,BRENDA,udpg,CHEBI:46229,glcp2
strong inhibition,2.4.1.1,C00038,,14,488238,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,glcp2
,2.4.1.227,C00132,,83,488978,,-,Methanol,Escherichia coli,BRENDA,meoh,CHEBI:17790,uagpt3
,2.4.1.227,,,38,488971,,-,,Escherichia coli,BRENDA,ni2,CHEBI:49786,uagpt3
"competitive inhibitor of UDP-GlcNAc donor, noncompetitive inhibitor of lipid I acceptor analogue",2.4.1.227,C00015,,26,488976,,-,UDP,Escherichia coli,BRENDA,udp,CHEBI:17659,uagpt3
,2.4.1.227,C00015,,26,703764,,-,UDP,Escherichia coli,BRENDA,udp,CHEBI:17659,uagpt3
,2.4.1.227,C00038,,14,488971,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,uagpt3
,2.4.2.1,C00212,,122,489693,,-,Adenosine,Escherichia coli,BRENDA,adn,CHEBI:16335,punp1
,2.4.2.1,C00559,,601,489693,,-,Deoxyadenosine,Escherichia coli,BRENDA,dad_2,CHEBI:17256,punp1
,2.4.2.1,C00242,,199,489654,,-,Guanine,Escherichia coli,BRENDA,gua,CHEBI:16235,punp1
product inhibition,2.4.2.3,C00009,,16,638518,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,pynp2r
product inhibition,2.4.2.3,C00620,,2355,"638518, 638520",,-,alpha-D-Ribose 1-phosphate,Escherichia coli,BRENDA,r1p,CHEBI:16300,pynp2r
product inhibition,2.4.2.3,C00106,,334,"638518, 638520",,-,Uracil,Escherichia coli,BRENDA,ura,CHEBI:17568,pynp2r
product inhibition,2.4.2.3,C00299,,261,638518,,-,Uridine,Escherichia coli,BRENDA,uri,CHEBI:16704,pynp2r
competitive,2.4.2.4,C00620,,2355,638444,,-,alpha-D-Ribose 1-phosphate,Escherichia coli,BRENDA,r1p,CHEBI:16300,duripp
inhibition reversed by phosphate,2.4.2.4,C00059,,245,638445,,-,Sulfate,Escherichia coli,BRENDA,so4,CHEBI:26836,duripp
,2.4.2.4,C00299,,261,672287,,-,Uridine,Escherichia coli,BRENDA,uri,CHEBI:16704,duripp
13% inhibition at 0.158 mM,2.4.2.4,C00385,,234,686525,,-,Xanthine,Escherichia coli,BRENDA,xan,CHEBI:48517,duripp
,2.4.2.8,C00020,,45234,638391,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,adpt
,2.4.2.8,C00130,,45239,638391,,-,IMP,Escherichia coli,BRENDA,imp,CHEBI:17202,adpt
strong,2.4.2.8,C00076,,15,638391,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,adpt
strong,2.4.2.8,C01228,,3703,638391,,-,"Guanosine 3',5'-bis(diphosphate)",Escherichia coli,BRENDA,ppgpp,CHEBI:17633,adpt
strong,2.4.2.8,C00038,,14,638391,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,adpt
inhibitory when higher concentrated as Mg2+,2.4.2.9,C00119,,29609,638369,,-,5-Phospho-alpha-D-ribose 1-diphosphate,Escherichia coli,BRENDA,prpp,CHEBI:17111,upprt
,2.4.2.9,C00460,,435,638361,,-,dUTP,Escherichia coli,BRENDA,dutp,CHEBI:17625,upprt
not inhibitory,2.4.2.10,C00147,,144,489719,,-,Adenine,Escherichia coli,BRENDA,ade,CHEBI:16708,orpt
not inhibitory,2.4.2.10,C00212,,122,489719,,-,Adenosine,Escherichia coli,BRENDA,adn,CHEBI:16335,orpt
not inhibitory,2.4.2.10,C00008,,13,489719,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,orpt
not inhibitory,2.4.2.10,C00020,,30,489719,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,orpt
not inhibitory,2.4.2.10,C00002,,4,489719,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,orpt
not inhibitory,2.4.2.10,C00075,,65,489719,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,orpt
,2.4.2.10,C00038,,14,489719,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,orpt
,2.4.2.14,C00008,,13,489747,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,gluprt
"approx. 10 mM, complete inhibition, sigmoidal inhibition curve, competitive vs. 5-phospho-alpha-D-ribose 1-diphosphate, GMP and AMP together have a synergistic effect on inhibition",2.4.2.14,C00020,,30,489747,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,gluprt
"4.7 mM, 50% inhibition",2.4.2.14,C00020,,30,489763,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,gluprt
,2.4.2.14,C00035,,53,489747,,-,GDP,Escherichia coli,BRENDA,gdp,CHEBI:17552,gluprt
"approx. 2.5 mM, complete inhibition, highly sigmoidal inhibition curve, competitive vs. 5-phospho-alpha-D-ribose 1-diphosphate, GMP and AMP together have an synergistic effect on inhibition",2.4.2.14,C00144,,162,489747,,-,GMP,Escherichia coli,BRENDA,gmp,CHEBI:17345,gluprt
"1.2-1.4 mM, 50% inhibition",2.4.2.14,C00144,,162,489763,,-,GMP,Escherichia coli,BRENDA,gmp,CHEBI:17345,gluprt
"5 mM, 79% inhibition",2.4.2.14,C00044,,37,489747,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,gluprt
"5 mM, 86% inhibition",2.4.2.14,C00130,,232,489747,,-,IMP,Escherichia coli,BRENDA,imp,CHEBI:17202,gluprt
51% inhibition; 5 mM,2.4.2.14,C00655,,1007,489747,,-,Xanthosine 5'-phosphate,Escherichia coli,BRENDA,xmp,CHEBI:15652,gluprt
"linear competitive inhibitor with respect to ATP, stabilizes the enzyme to thermal inactivation, protect the ordered enzymatic structure against thermodenaturation",2.4.2.17,C00020,,30,"637662, 637668",,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,atpprt
binding structure and inhibition mode,2.4.2.17,C00020,,30,659707,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,atpprt
inhibits the reaction at high concentrations,2.4.2.17,C00002,,4,637662,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,atpprt
"feed-back inhibition; stabilizes the enzyme to thermal inactivation, protects the ordered enzymatic structure against thermodenaturation, no interaction with binding sites",2.4.2.17,,,349,"637662, 637668",,-,,Escherichia coli,BRENDA,his__l,CHEBI:57595,atpprt
feed-back inhibition,2.4.2.17,,,349,"637667, 637674",,-,,Escherichia coli,BRENDA,his__l,CHEBI:57595,atpprt
"transferase activity of component II is only inhibitable by L-tryptophan when the component is in the complex, this inhibition does not appear to depend upon the feedback-sensitive site of complex I",2.4.2.18,,,119,638663,,-,,Escherichia coli,BRENDA,trp__l,CHEBI:57912,anprt
,2.4.2.18,,,119,638674,,-,,Escherichia coli,BRENDA,trp__l,CHEBI:57912,anprt
competitive with respect to 5-phosphoribosyl-1-diphosphate and noncompetitive with respect to quinolinate,2.4.2.19,C00354,,10623,638020,,-,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,nndpr
noncompetitive with respect to both 5-phosphoribosyl-1-diphosphate and quinolinate,2.4.2.19,C00013,,17,638020,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,nndpr
competitive with respect to 5-phosphoribosyl-1-diphosphate,2.4.2.19,C01185,,5194,638020,,-,Nicotinate D-ribonucleotide,Escherichia coli,BRENDA,nicrnt,CHEBI:15763,nndpr
,2.4.99.12,C06026,,74877,698691,,-,Di[3-deoxy-D-manno-octulosonyl]-lipid A,Escherichia coli,BRENDA,lipa,CHEBI:27963,moat
,2.4.99.13,C06026,,74877,698691,,-,Di[3-deoxy-D-manno-octulosonyl]-lipid A,Escherichia coli,BRENDA,lipa,CHEBI:27963,moat2
"0.5 mM, 50% inhibition, uncompetitive with respect to both substrates",2.5.1.3,C00227,,358,639722,,-,Acetyl phosphate,Escherichia coli,BRENDA,actp,CHEBI:15350,tmppp
"4 mM, 82.8% inhibition",2.5.1.3,C00227,,358,639723,,-,Acetyl phosphate,Escherichia coli,BRENDA,actp,CHEBI:15350,tmppp
,2.5.1.3,C00008,,13,639722,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,tmppp
"4 mM, 42.4% inhibition",2.5.1.3,C00008,,13,639723,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,tmppp
uncompetitive with respect to both substrates,2.5.1.3,C00002,,4,639722,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,tmppp
"4 mM, 64.7% inhibition",2.5.1.3,C00002,,4,639723,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,tmppp
,2.5.1.3,,,60,639722,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,tmppp
"4 mM, 58.7% inhibition",2.5.1.3,,,60,639723,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,tmppp
,2.5.1.3,C00013,,17,639722,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,tmppp
"0.05 mM, 50% inhibition",2.5.1.3,C00013,,17,639723,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,tmppp
,2.5.1.3,C00044,,37,639722,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,tmppp
"4 mM, 76.7% inhibition",2.5.1.3,C00044,,37,639723,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,tmppp
,2.5.1.3,C00074,,51,639722,,-,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,tmppp
"4 mM, 31.1% inhibition",2.5.1.3,C00074,,51,639723,,-,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,tmppp
,2.5.1.3,C00075,,65,639722,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,tmppp
"4 mM, 71.6% inhibition",2.5.1.3,C00075,,65,639723,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,tmppp
,2.5.1.6,C00013,,17,"639045, 639056",,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,metat
,2.5.1.6,C00044,,37,639056,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,metat
,2.5.1.6,C00009,,16,"639045, 639056",,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,metat
,2.5.1.6,C00019,,404,"639045, 639056",,-,S-Adenosyl-L-methionine,Escherichia coli,BRENDA,amet,CHEBI:15414,metat
,2.5.1.6,C00536,,739,639045,,-,Triphosphate,Escherichia coli,BRENDA,pppi,CHEBI:39949,metat
competitive with ATP,2.5.1.6,C00536,,739,639056,,-,Triphosphate,Escherichia coli,BRENDA,pppi,CHEBI:39949,metat
"metal ions do not enhance the activity of enzymes, activity is inhibited by 10 mM",2.5.1.7,C00175,,23,706916,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,uagcvt
"metal ions do not enhance the activity of enzymes, activity is inhibited by 10 mM",2.5.1.7,,,19,706916,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,uagcvt
"metal ions do not enhance the activity of enzymes, activity is inhibited by 10 mM",2.5.1.7,C14818,,25,706916,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,uagcvt
weak,2.5.1.7,C01050,,16007,637590,,-,UDP-N-acetylmuramate,Escherichia coli,BRENDA,uamr,CHEBI:70765,uagcvt
competitive with phosphate,2.5.1.7,C01050,,16007,658113,,-,UDP-N-acetylmuramate,Escherichia coli,BRENDA,uamr,CHEBI:70765,uagcvt
,2.5.1.7,C01050,,16007,702267,,-,UDP-N-acetylmuramate,Escherichia coli,BRENDA,uamr,CHEBI:70765,uagcvt
weak,2.5.1.7,C01212,,95310,637590,,-,UDP-N-acetylmuramoyl-L-alanine,Escherichia coli,BRENDA,uama,CHEBI:84726,uagcvt
weak,2.5.1.7,C00692,,44916,637590,,-,UDP-N-acetylmuramoyl-L-alanyl-D-glutamate,Escherichia coli,BRENDA,uamag,CHEBI:16970,uagcvt
above 1 mM,2.5.1.7,C04882,,20566,637590,,-,UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine,Escherichia coli,BRENDA,ugmda,CHEBI:18199,uagcvt
"metal ions do not enhance the activity of enzymes, activity is inhibited by 10 mM",2.5.1.7,C00038,,14,706916,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,uagcvt
,2.5.1.15,C00921,,20075,"639665, 639666",,-,Dihydropteroate,Escherichia coli,BRENDA,dhpt,CHEBI:4581,dhps2
W strain,2.5.1.16,C00170,,400,392545,,-,5'-Methylthioadenosine,Escherichia coli,BRENDA,5mta,CHEBI:17509,apcs
competitive substrate inhibition,2.5.1.16,C01137,,3271,"639708, 639709",,-,S-Adenosylmethioninamine,Escherichia coli,BRENDA,ametam,CHEBI:15625,apcs
W strain,2.5.1.16,C00315,,148,392545,,-,Spermidine,Escherichia coli,BRENDA,spmd,CHEBI:16610,apcs
,2.5.1.16,C00315,,148,"639706, 639707",,-,Spermidine,Escherichia coli,BRENDA,spmd,CHEBI:16610,apcs
product inhibition,2.5.1.19,C01269,,1668,638175,,-,5-O-(1-Carboxyvinyl)-3-phosphoshikimate,Escherichia coli,BRENDA,3psme,CHEBI:16257,pscvt
substrate inhibition,2.5.1.19,C00074,,51,638176,,-,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,pscvt
"20 mM, 85% inactivation after 1 h in the presence of cyanoborhydride, no inactivation in the absence of cyanoborhydride, preincubation with 5-enolpyruvylshikimate or a combination of shikimate 3-phosphate and glyphosate prevents from inactivation",2.5.1.19,C00022,,31,638178,,-,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,pscvt
inhibitory effect,2.5.1.39,C00076,,15,704240,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,hbzopt
inhibitory effect,2.5.1.39,C01413,,52,704240,,-,Cadmium,Escherichia coli,BRENDA,cd2,CHEBI:48775,hbzopt
inhibitory effect,2.5.1.39,,,19,704240,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,hbzopt
inhibitory effect,2.5.1.39,C14818,,25,704240,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,hbzopt
inhibitory effect,2.5.1.39,C00038,,14,704240,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,hbzopt
competitive with respect to phosphoenolpyruvate,2.5.1.54,,,750,639749,,-,,Escherichia coli,BRENDA,2pg,CHEBI:24344,ddpa
,2.5.1.54,C04691,,112551,639741,,-,2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate,Escherichia coli,BRENDA,2dda7p,CHEBI:18150,ddpa
"Tyr-sensitive isozyme, strong inhibition, reactivation by divalent cations only to a small extent",2.5.1.54,C01326,,159,639777,,-,Hydrogen cyanide,Escherichia coli,BRENDA,cyan,CHEBI:18407,ddpa
"0.02 mM, complete inactivation; Phe-sensitive isozyme, complete inactivation at 0.02 mM, destabilization of the enzymes quarternary structure; phosphoenolpyruvate protects",2.5.1.54,,,19,639771,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,ddpa
"Phe-sensitive isozyme: in absence of phosphoenolpyruvate the enzyme is inhibited via formation of a covalent binding to Lys186 via a slow Schiff base reaction, mechanism",2.5.1.54,C00279,,500,639796,,-,D-Erythrose 4-phosphate,Escherichia coli,BRENDA,e4p,CHEBI:48153,ddpa
,2.5.1.54,C00354,,583,639741,,-,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,ddpa
,2.5.1.54,C00447,,101771,639741,,-,"Sedoheptulose 1,7-bisphosphate",Escherichia coli,BRENDA,s17bp,CHEBI:17969,ddpa
,2.5.1.54,C05382,,3626,639741,,-,Sedoheptulose 7-phosphate,Escherichia coli,BRENDA,s7p,CHEBI:15721,ddpa
"0.02 mM: 60% inactivation. 0.2 mM: 90% inactivation; Phe-sensitive isozyme, 60% inactivation at 0.02 mM, 90% inactivation at 0.2 mM; phosphoenolpyruvate protects",2.5.1.54,C14818,,25,639771,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,ddpa
no inhibition,2.5.1.54,,,379,639746,,-,,Escherichia coli,BRENDA,phe__l,CHEBI:58095,ddpa
L-Phe; Phe-sensitive isozyme,2.5.1.54,,,379,639750,,-,,Escherichia coli,BRENDA,phe__l,CHEBI:58095,ddpa
L-Phe; Phe-sensitive isozyme; strong,2.5.1.54,,,379,639753,,-,,Escherichia coli,BRENDA,phe__l,CHEBI:58095,ddpa
"feed-back inhibition, Phe-sensitive isozyme; Phe-sensitive isozyme",2.5.1.54,,,379,"639771, 639775",,-,,Escherichia coli,BRENDA,phe__l,CHEBI:58095,ddpa
Phe-sensitive isozyme,2.5.1.54,,,379,"639768, 639776, 639796",,-,,Escherichia coli,BRENDA,phe__l,CHEBI:58095,ddpa
"1 Mn, wild-type 8.2% residual activity",2.5.1.54,,,429,659071,,-,,Escherichia coli,BRENDA,phe__l,CHEBI:58095,ddpa
non-competitive with respect to both phosphoenolpyruvate and D-erythrose 4-phosphate,2.5.1.54,C00009,,16,639747,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,ddpa
Trp-sensitive isozyme,2.5.1.54,,,817,639767,,-,,Escherichia coli,BRENDA,trp__l,CHEBI:57912,ddpa
"0.02 mM, 50% inhibition; Tyr-sensitive isozyme",2.5.1.54,,,618,639746,,-,,Escherichia coli,BRENDA,tyr__l,CHEBI:58315,ddpa
"feedback inhibition; noncompetitive with respect to D-erythrose 4-phosphate, competitive with respect to phosphoenolpyruvate; Tyr-sensitive isozyme",2.5.1.54,,,618,639747,,-,,Escherichia coli,BRENDA,tyr__l,CHEBI:58315,ddpa
L-Tyr; Tyr-sensitive isozyme,2.5.1.54,,,618,639750,,-,,Escherichia coli,BRENDA,tyr__l,CHEBI:58315,ddpa
Tyr-sensitive isozyme,2.5.1.54,,,618,"639753, 639777",,-,,Escherichia coli,BRENDA,tyr__l,CHEBI:58315,ddpa
,2.5.1.55,C01413,,52,637395,,-,Cadmium,Escherichia coli,BRENDA,cd2,CHEBI:48775,kdops
1 mM,2.5.1.55,C01413,,52,637397,,-,Cadmium,Escherichia coli,BRENDA,cd2,CHEBI:48775,kdops
1 mM,2.5.1.55,,,19,637397,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,kdops
,2.5.1.55,,,19,"637395, 637416",,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,kdops
reversed by dithiothreitol,2.5.1.55,C00703,,33,637395,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,kdops
1 mM,2.5.1.55,C00703,,33,637397,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,kdops
,2.5.1.55,C00009,,16,637397,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,kdops
1 mM,2.5.1.55,C00038,,14,637397,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,kdops
,2.5.1.55,C00038,,14,"637395, 637416",,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,kdops
"1 mM, inactivation",2.5.1.72,,,22,684659,,-,,Escherichia coli,BRENDA,h2o2,CHEBI:29192,qulns
"the activity of the enzyme within Escherichia coli is diminished by exposure of the cells to 4.2 atm O2, while the activity in extracts is rapidly decreased by 0.2 atm O2. Inactivation in extracts can be gradually reversed during anaerobic incubation, but is blocked by alpha, alpha'-dipyridyl or by 1,10-phenanthroline",2.5.1.72,,,9,684659,,-,,Escherichia coli,BRENDA,o2,CHEBI:27140,qulns
,2.6.1.11,,,19,644946,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,acota
,2.6.1.11,C00077,,192,644947,,-,L-Ornithine,Escherichia coli,BRENDA,orn,CHEBI:15729,acota
competitive with respect to D-fructose 6-phosphate,2.6.1.16,C01096,,22020,639929,,-,Sorbitol 6-phosphate,Escherichia coli,BRENDA,sbt6p,CHEBI:17044,gf6pta
"negative feedback-regulation at post-transcriptional level. The biological function of small RNA GlmZ is to positively control the enzyme's mRNA in response to D-glucosamine 6-phosphate concentrations. YhbJ, a gene of the rpoN operon, negatively regulates GlmZ",2.6.1.16,C00352,,501,689045,,-,D-Glucosamine 6-phosphate,Escherichia coli,BRENDA,gam6p,CHEBI:47987,gf6pta
"1 mM, about 50% loss of activity",2.6.1.16,C00352,,12491,672444,,-,D-Glucosamine 6-phosphate,Escherichia coli,BRENDA,gam6p,CHEBI:47987,gf6pta
competitive with respect to L-glutamine,2.6.1.16,C04322,,51635,639926,,-,Delta1-Pyrroline-5-carboxylate,Escherichia coli,BRENDA,1pyr5c,CHEBI:1372,gf6pta
,2.6.1.16,,,33180,639916,,-,,Escherichia coli,BRENDA,23dappa,CHEBI:57721,gf6pta
"at high concentrations, inhibition in both directions",2.6.1.17,C00026,,34,636965,,-,2-Oxoglutarate,Escherichia coli,BRENDA,akg,CHEBI:30915,sdpta
substrate inhibition,2.6.1.19,C00026,,34,661189,,-,2-Oxoglutarate,Escherichia coli,BRENDA,akg,CHEBI:30915,abta
,2.6.1.19,C00042,,58,661189,,-,Succinate,Escherichia coli,BRENDA,succ,CHEBI:15741,abta
complete inhibition at 0.5 mM,2.6.1.29,C01326,,118,639951,,-,Hydrogen cyanide,Escherichia coli,BRENDA,cyan,CHEBI:18407,spmdat2
,2.6.1.42,C00026,,5098,721470,,-,2-Oxoglutarate,Escherichia coli,BRENDA,akg,CHEBI:30915,ileta
17.5% activity in the presence of 10 mM,2.6.1.42,C00026,,5098,722933,,-,2-Oxoglutarate,Escherichia coli,BRENDA,akg,CHEBI:30915,ileta
,2.6.1.42,C00026,,34,722998,,-,2-Oxoglutarate,Escherichia coli,BRENDA,akg,CHEBI:30915,ileta
competitive with adenosyl-L-methionine,2.6.1.62,,,8030,"637092, 637094",,-,,Escherichia coli,BRENDA,8aonn,CHEBI:57532,amaotr
,2.6.1.62,,,8030,"637090, 637095",,-,,Escherichia coli,BRENDA,8aonn,CHEBI:57532,amaotr
,2.6.1.62,,,1494,661047,,-,,Escherichia coli,BRENDA,8aonn,CHEBI:57532,amaotr
8 mM,2.6.1.62,C00147,,144,637092,,-,Adenine,Escherichia coli,BRENDA,ade,CHEBI:16708,amaotr
5 mM,2.6.1.62,C00212,,122,637092,,-,Adenosine,Escherichia coli,BRENDA,adn,CHEBI:16335,amaotr
,2.6.1.62,C00212,,122,637094,,-,Adenosine,Escherichia coli,BRENDA,adn,CHEBI:16335,amaotr
5 mM,2.6.1.62,,,36,637092,,-,,Escherichia coli,BRENDA,ahcys,CHEBI:57856,amaotr
growing this microorganism in the presence of alanine represses transaminase C activity,2.6.1.66,,,103,640186,,-,,Escherichia coli,BRENDA,ala__l,CHEBI:57972,vpamtr
,2.6.1.66,,,103,640187,,-,,Escherichia coli,BRENDA,ala__l,CHEBI:57972,vpamtr
growing this microorganism in the presence of leucine represses transaminase C activity,2.6.1.66,,,127,640186,,-,,Escherichia coli,BRENDA,leu__l,CHEBI:57427,vpamtr
,2.6.1.66,,,127,640187,,-,,Escherichia coli,BRENDA,leu__l,CHEBI:57427,vpamtr
,2.7.1.11,C00002,,4,640421,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,pfk
at alkaline pH; mechanism,2.7.1.11,C00002,,4,640490,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,pfk
inhibition of fructose 1-phosphate phosphorylation above 0.08 mM ATP,2.7.1.11,C00002,,4,640526,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,pfk
strong inhibition,2.7.1.11,,,131,640421,,-,,Escherichia coli,BRENDA,cit,CHEBI:76049,pfk
isoenzyme PFK2,2.7.1.11,,,131,640463,,-,,Escherichia coli,BRENDA,cit,CHEBI:76049,pfk
"cAMP, ADP or fructose 1,6-bisphosphate restore activity",2.7.1.11,,,131,640486,,-,,Escherichia coli,BRENDA,cit,CHEBI:76049,pfk
,2.7.1.11,,,671,640421,,-,,Escherichia coli,BRENDA,f1p,CHEBI:78736,pfk
inhibition occurs at low concentrations of fructose 6-phosphate,2.7.1.11,C00085,,87,722736,,-,D-Fructose 6-phosphate,Escherichia coli,BRENDA,f6p,CHEBI:61553,pfk
,2.7.1.11,C00074,,51,"640421, 640463",,-,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,pfk
feedback inhibition,2.7.1.11,C00074,,51,640486,,-,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,pfk
,2.7.1.11,C00074,,51,722736,,-,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,pfk
inhibition above 5 mM,2.7.1.15,C00002,,4,641005,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,rbk
substrate inhibition,2.7.1.15,C00002,,4,673692,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,rbk
substrate inhibition,2.7.1.15,C00121,,292,673692,,-,D-Ribose,Escherichia coli,BRENDA,rib__d,CHEBI:47013,rbk
above 2.5 mM: gradual inhibition,2.7.1.15,C00305,,6,641005,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,rbk
,2.7.1.21,C00147,,144,641132,,-,Adenine,Escherichia coli,BRENDA,ade,CHEBI:16708,durik1
,2.7.1.21,C00033,,92882,641144,,-,Acetate,Escherichia coli,BRENDA,ac,CHEBI:15366,durik1
,2.7.1.21,C01327,,141,641144,,-,Hydrochloric acid,Escherichia coli,BRENDA,cl,CHEBI:17883,durik1
50-90% inhibition at 0.2-0.8 mM; competitive to thymidine,2.7.1.21,,,145,641117,,-,,Escherichia coli,BRENDA,dttp,CHEBI:37568,durik1
,2.7.1.21,,,145,641123,,-,,Escherichia coli,BRENDA,dttp,CHEBI:37568,durik1
,2.7.1.21,C00238,,39,641144,,-,Potassium cation,Escherichia coli,BRENDA,k,CHEBI:29103,durik1
,2.7.1.21,C01330,,59,641144,,-,Sodium cation,Escherichia coli,BRENDA,na1,CHEBI:29101,durik1
"0.01 mM, 61% inhibition",2.7.1.23,C00004,,8,641189,,-,NADH,Escherichia coli,BRENDA,nadh,CHEBI:16908,nadk
,2.7.1.23,C00004,,8,691390,,-,NADH,Escherichia coli,BRENDA,nadh,CHEBI:16908,nadk
"0.1 mM, 21% inhibition",2.7.1.23,C00006,,10,641189,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,nadk
"0.01 mM, 76% inhibition",2.7.1.23,C00005,,5,641189,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,nadk
,2.7.1.23,C00005,,5,691390,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,nadk
,2.7.1.25,C00224,,425,641215,,-,Adenylyl sulfate,Escherichia coli,BRENDA,aps,CHEBI:17709,adsk
"free form, reverse reaction, weak",2.7.1.25,C00008,,13,641215,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,adsk
"free form, weak inhibition; MgATP2-: product inhibition, reverse reaction",2.7.1.25,C00002,,4,641215,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,adsk
in excess,2.7.1.25,C01413,,52,641215,,-,Cadmium,Escherichia coli,BRENDA,cd2,CHEBI:48775,adsk
"in excess, activating below",2.7.1.25,C00175,,23,641215,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,adsk
,2.7.1.25,C00016,,20,641217,,-,FAD,Escherichia coli,BRENDA,fad,CHEBI:16238,adsk
"in excess, activating below",2.7.1.25,,,11,641215,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,adsk
thioredoxin reverses inactivation,2.7.1.25,C00127,,1794,641217,,-,Glutathione disulfide,Escherichia coli,BRENDA,gthox,CHEBI:17858,adsk
,2.7.1.30,C00008,,13,"641287, 641294",,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,glyk
substrate inhibition,2.7.1.30,C00002,,4,722712,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,glyk
,2.7.1.30,C00354,,106,701931,,-,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,glyk
allosteric inhibition,2.7.1.30,C00354,,1895,722712,,-,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,glyk
,2.7.1.30,C00354,,1755,661122,,-,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,glyk
,2.7.1.30,C00354,,295,"641287, 641294, 641295, 641309",,-,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,glyk
"normal enzyme is inhibited, genetically altered enzyme not, inhibition is reduced by high pH, high ionic strength or 0.2 M guanidine HCl",2.7.1.30,C00354,,295,641311,,-,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,glyk
mechanism,2.7.1.30,C00354,,295,641326,,-,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,glyk
,2.7.1.30,,,445,641287,,-,,Escherichia coli,BRENDA,glyc3p,CHEBI:57597,glyk
,2.7.1.33,C00332,,187,641393,,-,Acetoacetyl-CoA,Escherichia coli,BRENDA,aacoa,CHEBI:15345,pntk
,2.7.1.33,C00024,,29,641393,,-,Acetyl-CoA,Escherichia coli,BRENDA,accoa,CHEBI:15351,pntk
,2.7.1.33,C00008,,13,641393,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,pntk
,2.7.1.33,C00020,,30,641393,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,pntk
in vitro; in vivo; kinetics,2.7.1.33,C00010,,18,641393,,-,CoA,Escherichia coli,BRENDA,coa,CHEBI:15346,pntk
feedback inhibitor,2.7.1.33,C00010,,18,671053,,-,CoA,Escherichia coli,BRENDA,coa,CHEBI:15346,pntk
competitive,2.7.1.33,C00010,,18,686816,,-,CoA,Escherichia coli,BRENDA,coa,CHEBI:15346,pntk
"allosteric regulator, feedback inhibition",2.7.1.33,C00010,,534,662251,,-,CoA,Escherichia coli,BRENDA,coa,CHEBI:15346,pntk
not,2.7.1.33,C00882,,2018,641393,,-,Dephospho-CoA,Escherichia coli,BRENDA,dpcoa,CHEBI:15468,pntk
,2.7.1.33,C00083,,76,641393,,-,Malonyl-CoA,Escherichia coli,BRENDA,malcoa,CHEBI:15531,pntk
,2.7.1.33,,,128,641393,,-,,Escherichia coli,BRENDA,pmtcoa,CHEBI:57379,pntk
not,2.7.1.33,C01134,,4854,641393,,-,Pantetheine 4'-phosphate,Escherichia coli,BRENDA,pan4p,CHEBI:4222,pntk
,2.7.1.33,C00091,,224,641393,,-,Succinyl-CoA,Escherichia coli,BRENDA,succoa,CHEBI:15380,pntk
mixed inhibition versus L-homoserine and ATP,2.7.1.39,C00441,,15814,641463,,-,L-Aspartate 4-semialdehyde,Escherichia coli,BRENDA,aspsa,CHEBI:18051,hsk
,2.7.1.39,,,336,"641470, 641471",,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,hsk
,2.7.1.39,C00025,,1163,641471,,-,L-Glutamate,Escherichia coli,BRENDA,glu__l,CHEBI:16015,hsk
,2.7.1.39,,,305,641470,,-,,Escherichia coli,BRENDA,hcys__l,CHEBI:58199,hsk
above 0.75 mM,2.7.1.39,,,345,641463,,-,,Escherichia coli,BRENDA,hom__l,CHEBI:57476,hsk
,2.7.1.39,,,345,641471,,-,,Escherichia coli,BRENDA,hom__l,CHEBI:57476,hsk
substrate inhibition,2.7.1.39,,,345,641473,,-,,Escherichia coli,BRENDA,hom__l,CHEBI:57476,hsk
,2.7.1.39,,,1074,641470,,-,,Escherichia coli,BRENDA,ile__l,CHEBI:58045,hsk
,2.7.1.39,,,468,641470,,-,,Escherichia coli,BRENDA,met__l,CHEBI:57844,hsk
,2.7.1.39,,,262,641470,,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,hsk
,2.7.1.39,,,780,641465,,-,,Escherichia coli,BRENDA,thr__l,CHEBI:57926,hsk
competitive to the substrate L-homoserine,2.7.1.39,,,780,641470,,-,,Escherichia coli,BRENDA,thr__l,CHEBI:57926,hsk
substrate inhibition,2.7.1.39,,,780,641471,,-,,Escherichia coli,BRENDA,thr__l,CHEBI:57926,hsk
,2.7.1.39,,,835,641470,,-,,Escherichia coli,BRENDA,val__l,CHEBI:57762,hsk
,2.7.1.39,C01005,,1189,641471,,-,O-Phospho-L-serine,Escherichia coli,BRENDA,pser__l,CHEBI:15811,hsk
,2.7.1.39,C00018,,32,641473,,-,Pyridoxal phosphate,Escherichia coli,BRENDA,pydx5p,CHEBI:18405,hsk
,2.7.1.40,C00076,,15,654470,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,pyk
"divalent cation required, most effective at a ratio of Mn2+ and ATP of 1:3, deviation from this ratio is inhibitory at several concentration levels",2.7.1.45,,,11,636960,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,ddglk
,2.7.1.48,,,60,641644,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,cytdk2
,2.7.1.48,C00075,,65,641644,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,cytdk2
competitive inhibition,2.7.1.49,C01279,,7509,641658,,-,4-Amino-5-hydroxymethyl-2-methylpyrimidine,Escherichia coli,BRENDA,4ahmmp,CHEBI:16892,hmpk1
inhibits competitively the phosphorylation of 2-methyl-4-amino-5-hydroxymethylpyrimidine,2.7.1.49,C00314,,1051,641658,,-,Pyridoxine,Escherichia coli,BRENDA,pydxn,CHEBI:16709,hmpk1
kinetics,2.7.1.56,C00008,,13,641683,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,fruk
kinetics,2.7.1.56,C00354,,106,641683,,-,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,fruk
strong competitive inhibitor,2.7.1.59,C00008,,13,641692,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,acgamk
"monomeric fusion-protein of integral membrane subunit IICBGlc and malotose-binding protein exhibits no substrate inhibition although the oligomeric form does. Purification promotes subunit association, an increase in catalytic activity, and restoration of substrate inhibition",2.7.1.69,C00092,,105,692907,,-,D-Glucose 6-phosphate,Escherichia coli,BRENDA,g6p,CHEBI:4170,treptspp
,2.7.1.69,C00031,,223,641885,,-,D-Glucose,Escherichia coli,BRENDA,glc__d,CHEBI:4167,treptspp
strong substrate inhibition at neutral pH in the transphosphorylation reaction,2.7.1.69,C00644,,5992,641866,,-,D-Mannitol 1-phosphate,Escherichia coli,BRENDA,mnl1p,CHEBI:16298,treptspp
,2.7.1.73,,,19,641925,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,gsnk
,2.7.1.73,C00035,,53,641928,,-,GDP,Escherichia coli,BRENDA,gdp,CHEBI:17552,gsnk
,2.7.1.73,C00044,,37,641928,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,gsnk
,2.7.1.73,C00038,,14,641925,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,gsnk
,2.7.1.107,C00076,,15,640352,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,dagk160
,2.7.2.4,C00025,,41,642329,,-,L-Glutamate,Escherichia coli,BRENDA,glu__l,CHEBI:16015,aspk
,2.7.2.4,,,345,642329,,-,,Escherichia coli,BRENDA,hom__l,CHEBI:57476,aspk
"binding of L-lysine to the regulatory ACT1 domain in R-state AKIII instigates a series of changes that release a 'latch', the beta15-alphaK loop, from the catalytic domain, which in turn undergoes large rotational rearrangements, promoting tetramer formation and completion of the transition to the T-state. L-lysine-induced allosteric transition in AKIII involves both destabilizing the R-state and stabilizing the T-state tetramer. Rearrangement of the catalytic domain blocks the ATP-binding site, which is therefore the structural basis for allosteric inhibition of AKIII by L-lysine",2.7.2.4,C00047,,134,680701,,-,L-Lysine,Escherichia coli,BRENDA,lys__l,CHEBI:18019,aspk
,2.7.2.4,C00047,,134,"642314, 642317, 722849",,-,L-Lysine,Escherichia coli,BRENDA,lys__l,CHEBI:18019,aspk
,2.7.2.4,C00149,,247,642329,,-,(S)-Malate,Escherichia coli,BRENDA,mal__l,CHEBI:30797,aspk
feedback inhibition,2.7.2.4,,,250,654640,,-,,Escherichia coli,BRENDA,thr__l,CHEBI:57926,aspk
,2.7.2.4,,,250,"642310, 642311, 642314, 722849",,-,,Escherichia coli,BRENDA,thr__l,CHEBI:57926,aspk
,2.7.2.4,C00042,,58,642329,,-,Succinate,Escherichia coli,BRENDA,succ,CHEBI:15741,aspk
enzyme has no allosteric properties and its activity is influenced neither by arginine nor by any of the intermediates of the arginine biosynthetic pathway,2.7.2.8,C00062,,532,642354,,-,L-Arginine,Escherichia coli,BRENDA,arg__l,CHEBI:16467,acgk
,2.7.2.8,C00002,,4,659704,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,acgk
,2.7.2.11,C00008,,13,642200,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,glu5k
AAK domain is responsible for inhibition,2.7.2.11,,,243,681421,,-,,Escherichia coli,BRENDA,pro__l,CHEBI:60039,glu5k
,2.7.2.11,,,243,"679845, 722974",,-,,Escherichia coli,BRENDA,pro__l,CHEBI:60039,glu5k
,2.7.4.3,C00020,,30,642586,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,adk1
,2.7.4.3,C04058,,22346,702283,,-,Bis(5'-adenosyl) pentaphosphate,Escherichia coli,BRENDA,ap5a,CHEBI:28898,adk1
1 µM,2.7.4.3,C04058,,2151,660819,,-,Bis(5'-adenosyl) pentaphosphate,Escherichia coli,BRENDA,ap5a,CHEBI:28898,adk1
,2.7.4.3,C04058,,2151,675337,,-,Bis(5'-adenosyl) pentaphosphate,Escherichia coli,BRENDA,ap5a,CHEBI:28898,adk1
,2.7.4.9,C00458,,179,645198,,-,dCTP,Escherichia coli,BRENDA,dctp,CHEBI:16311,dtmpk
,2.7.4.9,,,145,645198,,-,,Escherichia coli,BRENDA,dttp,CHEBI:37568,dtmpk
,2.7.4.9,C00365,,602,645198,,-,dUMP,Escherichia coli,BRENDA,dump,CHEBI:17622,dtmpk
product inhibition,2.7.4.16,C00008,,13,642545,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,tmpk
,2.7.4.16,C00020,,30,642545,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,tmpk
,2.7.4.16,C00013,,17,642545,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,tmpk
antagonizes stimulation by K+,2.7.4.16,C01330,,59,642545,,-,Sodium cation,Escherichia coli,BRENDA,na1,CHEBI:29101,tmpk
,2.7.4.16,,,642,642545,,-,,Escherichia coli,BRENDA,thm,CHEBI:49107,tmpk
,2.7.6.1,C00008,,13,642710,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,prpps
nonlinear competitive inhibition,2.7.6.1,C00008,,13,642737,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,prpps
inhibition even in presence of excess Mg2+,2.7.6.1,C00076,,15,"642710, 642732",,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,prpps
,2.7.6.1,C00076,,15,642737,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,prpps
,2.7.7.3,C00010,,18,674344,,-,CoA,Escherichia coli,BRENDA,coa,CHEBI:15346,ptpati
,2.7.7.3,C00882,,2018,674344,,-,Dephospho-CoA,Escherichia coli,BRENDA,dpcoa,CHEBI:15468,ptpati
,2.7.7.3,C00013,,17,674344,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,ptpati
,2.7.7.3,C01134,,6013,674344,,-,Pantetheine 4'-phosphate,Escherichia coli,BRENDA,pan4p,CHEBI:4222,ptpati
,2.7.7.9,C00842,,1766,643748,,-,dTDP-glucose,Escherichia coli,BRENDA,dtdpglu,CHEBI:15700,galui
,2.7.7.9,C03319,,112019,643748,,-,dTDP-L-rhamnose,Escherichia coli,BRENDA,dtdprmn,CHEBI:15774,galui
product/substrate inhibition,2.7.7.12,C00446,,493,642838,,-,alpha-D-Galactose 1-phosphate,Escherichia coli,BRENDA,gal1p,CHEBI:17973,uglt
competitive substrate inhibition in the forward reaction,2.7.7.12,C00446,,493,722427,,-,alpha-D-Galactose 1-phosphate,Escherichia coli,BRENDA,gal1p,CHEBI:17973,uglt
product/substrate inhibition,2.7.7.12,C00103,,107,642838,,-,D-Glucose 1-phosphate,Escherichia coli,BRENDA,g1p,CHEBI:29042,uglt
product/substrate inhibition,2.7.7.12,C00052,,129,642838,,-,UDP-alpha-D-galactose,Escherichia coli,BRENDA,udpgal,CHEBI:67119,uglt
the product of the forward reaction is a competitive inhibitor with respect to UDP-glucose and a mixed inhibitor with respect to galactose 1-phosphate,2.7.7.12,C00052,,129,722427,,-,UDP-alpha-D-galactose,Escherichia coli,BRENDA,udpgal,CHEBI:67119,uglt
product/substrate inhibition,2.7.7.12,C00029,,64,642838,,-,UDP-glucose,Escherichia coli,BRENDA,udpg,CHEBI:46229,uglt
deamido-NAD+ as substrate,2.7.7.18,C00003,,7,642778,,-,NAD+,Escherichia coli,BRENDA,nad,CHEBI:15846,nmnat
slight product inhibition in reverse reaction,2.7.7.23,C00043,,126,288685,,-,UDP-N-acetyl-alpha-D-glucosamine,Escherichia coli,BRENDA,uacgam,CHEBI:16264,uagdp
competitive to dTTP,2.7.7.24,C00842,,903,643081,,-,dTDP-glucose,Escherichia coli,BRENDA,dtdpglu,CHEBI:15700,g1ptt
competitive to dTDPglucose and non-competitive to alpha-D-glucose 1-phosphate,2.7.7.24,,,145,643081,,-,,Escherichia coli,BRENDA,dttp,CHEBI:37568,g1ptt
allosteric inhibitor; not,2.7.7.27,C00008,,13,643144,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,glgc
,2.7.7.27,C00008,,13,"643161, 643164",,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,glgc
comparison of inhibition of wild-type and chimeric enzymes,2.7.7.27,C00020,,30,643152,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,glgc
,2.7.7.27,C00020,,30,"643126, 643127, 643148, 643150, 643161, 643164, 661743, 663026",,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,glgc
physiological relevant inhibition,2.7.7.27,C00044,,37,643126,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,glgc
"in vitro, no physiological relevance",2.7.7.27,C00009,,16,643126,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,glgc
allosteric inhibitor,2.7.7.27,C00009,,16,"643127, 643144",,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,glgc
,2.7.7.27,C00009,,16,"643141, 643161, 643164",,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,glgc
,2.7.7.27,C00074,,51,"643144, 643161",,-,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,glgc
,2.7.7.27,C00689,,1514,643144,,-,"alpha,alpha'-Trehalose 6-phosphate",Escherichia coli,BRENDA,tre6p,CHEBI:18283,glgc
weak inhibition,2.7.7.38,C00013,,17,645227,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,kdoct2
strong inhibition,2.7.7.38,C00703,,33,645227,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,kdoct2
,2.7.7.41,,,60,643308,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,dasyn120
competitive with dCTP,2.7.7.41,,,60,643314,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,dasyn120
competitive with respect to CTP,2.7.7.41,C00458,,179,643314,,-,dCTP,Escherichia coli,BRENDA,dctp,CHEBI:16311,dasyn120
substrate inhibition,2.7.7.60,,,60,661089,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,mepct
"0.13 mM, 50% inhibition",2.7.7.63,,,19,663919,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,lipatpt
,2.7.8.5,C00076,,15,644289,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,pgsa120
inhibition of CDP-diacylglycerol formation,2.7.8.5,,,445,644286,,-,,Escherichia coli,BRENDA,glyc3p,CHEBI:57597,pgsa120
"required, Km: 50 mM, inhibition above 150 mM",2.7.8.5,C00305,,6,644290,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,pgsa120
substrate inhibition,2.7.8.7,C03688,,1664,645395,,-,Apo-[acyl-carrier-protein],Escherichia coli,BRENDA,apoacp,CHEBI:16139,acps1
,2.7.8.7,C03688,,1664,645401,,-,Apo-[acyl-carrier-protein],Escherichia coli,BRENDA,apoacp,CHEBI:16139,acps1
,2.7.9.2,C00026,,34,"645472, 645473",,-,2-Oxoglutarate,Escherichia coli,BRENDA,akg,CHEBI:30915,pps
,2.7.9.2,C00661,,29510,645472,,-,Glyceraldehyde 3-phosphate,Escherichia coli,BRENDA,g3p,CHEBI:17138,pps
weak,2.7.9.2,C00661,,29510,645473,,-,Glyceraldehyde 3-phosphate,Escherichia coli,BRENDA,g3p,CHEBI:17138,pps
,2.7.9.2,C00008,,13,"645472, 645473",,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,pps
weak,2.7.9.2,C00498,,598,645473,,-,ADP-glucose,Escherichia coli,BRENDA,adpglc,CHEBI:15751,pps
,2.7.9.2,C00020,,30,645473,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,pps
excess of ATP inhibits at high concentrations of MgCl2 or MnCl2,2.7.9.2,C00002,,4,645468,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,pps
inhibits Mn2+-activated enzyme,2.7.9.2,C00076,,15,645468,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,pps
"divalent metal ion Mg2+ or Mn2+ required for forward reaction, inhibition at high concentrations of Mg2+ or Mn2+",2.7.9.2,C00305,,6,645468,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,pps
"divalent metal ion Mg2+ or Mn2+ required for forward reaction, inhibition at high concentrations of Mg2+ or Mn2+",2.7.9.2,,,11,645468,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,pps
,2.7.9.2,C00036,,2575,"645472, 645473",,-,Oxaloacetate,Escherichia coli,BRENDA,oaa,CHEBI:30744,pps
competitive to ATP,2.7.9.2,C00074,,51,645473,,-,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,pps
competitive to ATP,2.7.9.3,C00020,,30,645479,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,selnps
62% inhibition at 10 mM,2.7.9.3,,,22,645490,,-,,Escherichia coli,BRENDA,h2o2,CHEBI:29192,selnps
in presence of K+,2.7.9.3,C01330,,59,"645479, 645483",,-,Sodium cation,Escherichia coli,BRENDA,na1,CHEBI:29101,selnps
weak,2.7.9.3,C00009,,16,645479,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,selnps
weak,2.7.9.3,C05172,,4899,645479,,-,Selenophosphoric acid,Escherichia coli,BRENDA,selnp,CHEBI:64331,selnps
decreases binding of Mn-ATP2- to the enzyme,2.7.9.3,C00038,,14,645483,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,selnps
,2.7.9.3,C00038,,14,661912,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,selnps
,2.8.1.1,C01326,,159,645502,,-,Hydrogen cyanide,Escherichia coli,BRENDA,cyan,CHEBI:18407,cyanst
,2.8.1.1,C00094,,902,645502,,-,Sulfite,Escherichia coli,BRENDA,so3,CHEBI:48854,cyanst
substrate inhibition at low concentrations of cyanide,2.8.1.1,C05529,,475,645532,,-,Thiosulfuric acid,Escherichia coli,BRENDA,tsul,CHEBI:5587,cyanst
"inhibits at short-time intervals, slight enhancement at longer periods",2.8.1.2,C01326,,118,645548,,-,Hydrogen cyanide,Escherichia coli,BRENDA,cyan,CHEBI:18407,mcpst
,2.8.1.2,,,153,645548,,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,mcpst
"10 mM: 17% inhibition, 20 mM: 45% inhibition",2.8.1.2,C00022,,31,645548,,-,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,mcpst
,2.8.3.16,C00024,,29,692851,,-,Acetyl-CoA,Escherichia coli,BRENDA,accoa,CHEBI:15351,forct
free CoA,2.8.3.16,C00010,,534,692851,,-,CoA,Escherichia coli,BRENDA,coa,CHEBI:15346,forct
substrate inhibition,2.8.3.16,C00209,,185,692851,,-,Oxalate,Escherichia coli,BRENDA,oxa,CHEBI:16995,forct
,3.1.1.5,C14818,,25,94382,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,lplipal1a120pp
,3.1.1.5,C14819,,70,94382,,-,Fe3+,Escherichia coli,BRENDA,fe3,CHEBI:29034,lplipal1a120pp
,3.1.3.5,C00020,,236,664087,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,ntd10
,3.1.3.5,C00008,,13,656266,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,ntd10
,3.1.3.5,C00002,,4,656266,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,ntd10
,3.1.3.5,C00002,,4,95061,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,ntd10
,3.1.3.5,,,60,656266,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,ntd10
,3.1.3.5,C00131,,140,656266,,-,dATP,Escherichia coli,BRENDA,datp,CHEBI:16284,ntd10
,3.1.3.5,C00458,,179,656266,,-,dCTP,Escherichia coli,BRENDA,dctp,CHEBI:16311,ntd10
,3.1.3.5,C00286,,219,656266,,-,dGTP,Escherichia coli,BRENDA,dgtp,CHEBI:16497,ntd10
,3.1.3.5,,,145,656266,,-,,Escherichia coli,BRENDA,dttp,CHEBI:37568,ntd10
,3.1.3.5,C00044,,37,656266,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,ntd10
,3.1.3.5,C00081,,229,656266,,-,ITP,Escherichia coli,BRENDA,itp,CHEBI:16039,ntd10
,3.1.3.5,,,523,656266,,-,,Escherichia coli,BRENDA,dttp,CHEBI:37568,ntd10
,3.1.3.5,C00075,,65,656266,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,ntd10
,3.1.3.6,C00002,,4,656266,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,3ntd2pp
,3.1.3.6,,,60,656266,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,3ntd2pp
,3.1.3.6,C00131,,140,656266,,-,dATP,Escherichia coli,BRENDA,datp,CHEBI:16284,3ntd2pp
,3.1.3.6,C00458,,179,656266,,-,dCTP,Escherichia coli,BRENDA,dctp,CHEBI:16311,3ntd2pp
,3.1.3.6,C00286,,219,656266,,-,dGTP,Escherichia coli,BRENDA,dgtp,CHEBI:16497,3ntd2pp
,3.1.3.6,,,145,656266,,-,,Escherichia coli,BRENDA,dttp,CHEBI:37568,3ntd2pp
,3.1.3.6,C00044,,37,656266,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,3ntd2pp
,3.1.3.6,C00081,,229,656266,,-,ITP,Escherichia coli,BRENDA,itp,CHEBI:16039,3ntd2pp
,3.1.3.6,,,523,656266,,-,,Escherichia coli,BRENDA,dttp,CHEBI:37568,3ntd2pp
,3.1.3.6,C00075,,65,656266,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,3ntd2pp
activity is decreased to approximately 70% in the presence of 10 mM MgCl2,3.1.3.7,C00305,,6,677696,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,bpnt
,3.1.3.11,C00008,,13,651666,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,fbp
50% inhibition at 0.015 mM,3.1.3.11,C00020,,30,170730,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,fbp
"transformation of enzyme to inactive T-state, inhibition shows quarternary transition and cooperativity",3.1.3.11,C00020,,30,665621,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,fbp
,3.1.3.11,C00020,,30,"650375, 680756",,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,fbp
FBPase undergoes a quaternary transition from the canonical R-state to a T-like state in response to AMP. Glc-6-P and AMP are synergistic inhibitors,3.1.3.11,C00020,,30,680799,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,fbp
"AMP and D-fructose 2,6-bisphosphate are not synergistic inhibitors of the type I FBPase",3.1.3.11,C00020,,30,680855,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,fbp
,3.1.3.11,C00002,,4,651666,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,fbp
"1 mM, reduces activity by 40%",3.1.3.11,C00002,,4,693243,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,fbp
substrate inhibition at high concentrations,3.1.3.11,C00354,,106,651666,,-,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,fbp
,3.1.3.11,,,671,651666,,-,,Escherichia coli,BRENDA,f1p,CHEBI:78736,fbp
allosteric inhibition. FBPase undergoes a quaternary transition from the canonical R-state to a T-like state in response to glucose 6-phosphate. Glc-6-P and AMP are synergistic inhibitors,3.1.3.11,C00092,,105,680799,,-,D-Glucose 6-phosphate,Escherichia coli,BRENDA,g6p,CHEBI:4170,fbp
substrate inhibition above 0.05 M,3.1.3.11,C00354,,295,170730,,-,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,fbp
,3.1.3.11,C00009,,16,"651666, 693243",,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,fbp
,3.1.3.11,C00009,,16,693243,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,fbp
,3.1.3.11,C00074,,51,170730,,-,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,fbp
"0.1 mM, no activity",3.1.3.15,C00076,,15,680722,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,histp
,3.1.3.25,C00076,,15,665294,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,mi1pp
activity is significantly reduced at high concentrations of Mg2+,3.1.3.25,C00305,,6,729888,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,mi1pp
,3.1.3.27,C00703,,33,94818,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,pgpp120
,3.1.3.27,C00009,,16,94810,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,pgpp120
little effect up to 10 mM,3.1.3.27,C00009,,16,94818,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,pgpp120
,3.1.3.45,C00076,,15,"646344, 652389",,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,kdopp
,3.1.3.45,C01413,,52,"646344, 652389",,-,Cadmium,Escherichia coli,BRENDA,cd2,CHEBI:48775,kdopp
,3.1.3.45,C01327,,141,646344,,-,Hydrochloric acid,Escherichia coli,BRENDA,cl,CHEBI:17883,kdopp
,3.1.3.45,,,19,"646344, 652389",,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,kdopp
,3.1.3.45,C00703,,33,"646344, 652389",,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,kdopp
"0.2 mM, 21% residual activity",3.1.3.89,C00008,,13,656266,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,ntd1
"0.2 mM, 18% residual activity",3.1.3.89,C00002,,4,656266,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,ntd1
"0.2 mM, 29% residual activity",3.1.3.89,,,60,656266,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,ntd1
"0.2 mM, 15% residual activity",3.1.3.89,C00131,,140,656266,,-,dATP,Escherichia coli,BRENDA,datp,CHEBI:16284,ntd1
"0.2 mM, 19% residual activity",3.1.3.89,C00458,,179,656266,,-,dCTP,Escherichia coli,BRENDA,dctp,CHEBI:16311,ntd1
"0.2 mM, 13% residual activity",3.1.3.89,C00286,,219,656266,,-,dGTP,Escherichia coli,BRENDA,dgtp,CHEBI:16497,ntd1
"0.2 mM, 15% residual activity",3.1.3.89,,,145,656266,,-,,Escherichia coli,BRENDA,dttp,CHEBI:37568,ntd1
"0.2 mM, 28% residual activity",3.1.3.89,C00044,,37,656266,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,ntd1
"0.2 mM, 29% residual activity",3.1.3.89,C00081,,229,656266,,-,ITP,Escherichia coli,BRENDA,itp,CHEBI:16039,ntd1
"0.2 mM, 14% residual activity",3.1.3.89,,,523,656266,,-,,Escherichia coli,BRENDA,dttp,CHEBI:37568,ntd1
"0.2 mM, 26% residual activity",3.1.3.89,C00075,,65,656266,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,ntd1
,3.1.4.16,C00020,,236,652555,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,23pde2pp
,3.1.4.16,C00009,,16,693167,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,23pde2pp
1 mM,3.1.4.16,C00038,,14,135196,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,23pde2pp
,3.1.4.16,C00038,,14,135203,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,23pde2pp
4 mM,3.1.4.46,C00305,,6,646457,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,gpdda1
4 mM,3.1.4.46,,,11,646457,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,gpdda1
competitive inhibitor,3.1.5.1,C00286,,219,135502,,-,dGTP,Escherichia coli,BRENDA,dgtp,CHEBI:16497,ntptp1
competitive inhibitor,3.1.5.1,C00044,,37,135502,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,ntptp1
,3.2.1.20,,,19,393267,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,mltg1
,3.2.1.20,C00703,,33,393267,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,mltg1
30-50 mM,3.2.1.20,C00238,,39,393267,,-,Potassium cation,Escherichia coli,BRENDA,k,CHEBI:29103,mltg1
,3.2.1.23,,,75,"171273, 679236",,-,,Escherichia coli,BRENDA,ag,CHEBI:49468,lacz
"activates at 50-100 mg/l, inhibits at concentrations above 200 mg/l",3.2.1.23,C00076,,15,679236,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,lacz
,3.2.1.23,C01353,,2953,679236,,-,Carbonic acid,Escherichia coli,BRENDA,hco3,CHEBI:28976,lacz
,3.2.1.23,C01413,,52,171273,,-,Cadmium,Escherichia coli,BRENDA,cd2,CHEBI:48775,lacz
,3.2.1.23,C01327,,298,679236,,-,Hydrochloric acid,Escherichia coli,BRENDA,cl,CHEBI:17883,lacz
,3.2.1.23,,,131,171271,,-,,Escherichia coli,BRENDA,cit,CHEBI:76049,lacz
slight inhibition at 200 mg/l,3.2.1.23,,,1714,679236,,-,,Escherichia coli,BRENDA,cit,CHEBI:76049,lacz
,3.2.1.23,,,19,"171273, 679236",,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,lacz
,3.2.1.23,C00124,,71,"706614, 706624",,-,D-Galactose,Escherichia coli,BRENDA,gal,CHEBI:4139,lacz
,3.2.1.23,C00189,,456,171271,,-,Ethanolamine,Escherichia coli,BRENDA,etha,CHEBI:16000,lacz
"activates at 50-100 mg/l, inhibits at concentrations above 200 mg/l",3.2.1.23,C14818,,25,679236,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,lacz
,3.2.1.23,C00703,,33,171273,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,lacz
,3.2.1.23,C00038,,14,171273,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,lacz
"0.5 M KCl, activity is 2fold lower",3.2.1.28,C00238,,39,136178,,-,Potassium cation,Escherichia coli,BRENDA,k,CHEBI:29103,treh
"0.5 M NaCl, activity is 2fold lower",3.2.1.28,C01330,,59,136178,,-,Sodium cation,Escherichia coli,BRENDA,na1,CHEBI:29101,treh
,3.2.1.86,C00575,,5478,136924,,-,"3',5'-Cyclic AMP",Escherichia coli,BRENDA,camp,CHEBI:17489,ab6pgh
,3.2.1.86,C00020,,30,136924,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,ab6pgh
,3.2.1.86,C00002,,4,136924,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,ab6pgh
,3.2.1.86,C00055,,100,136924,,-,CMP,Escherichia coli,BRENDA,cmp,CHEBI:17361,ab6pgh
,3.2.1.86,,,102724,136924,,-,,Escherichia coli,BRENDA,glyc3p,CHEBI:57597,ab6pgh
,3.2.1.86,C00354,,93410,136924,,-,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,ab6pgh
,3.2.1.86,C00004,,8,136924,,-,NADH,Escherichia coli,BRENDA,nadh,CHEBI:16908,ab6pgh
,3.2.1.86,C00074,,51,136924,,-,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,ab6pgh
,3.2.2.4,C00009,,16,"171815, 171827, 171829",,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,ampn
"; conformational changes upon inhibitor binding, additional phosphate binding site, overview",3.2.2.4,C00009,,16,657368,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,ampn
,3.2.2.4,C00059,,160,171817,,-,Sulfate,Escherichia coli,BRENDA,so4,CHEBI:26836,ampn
,3.2.2.9,C00170,,400,171857,,-,5'-Methylthioadenosine,Escherichia coli,BRENDA,5mta,CHEBI:17509,ahcysns
poor inhibitor,3.2.2.9,C00147,,144,171854,,-,Adenine,Escherichia coli,BRENDA,ade,CHEBI:16708,ahcysns
,3.2.2.9,C00147,,144,"171851, 171857",,-,Adenine,Escherichia coli,BRENDA,ade,CHEBI:16708,ahcysns
recombinant MTA/SAH'ase (rMTAN),3.2.2.9,C00147,,144,171859,,-,Adenine,Escherichia coli,BRENDA,ade,CHEBI:16708,ahcysns
,3.2.2.9,C00212,,122,171857,,-,Adenosine,Escherichia coli,BRENDA,adn,CHEBI:16335,ahcysns
; moderate inhibitor,3.2.2.9,,,36,171857,,-,,Escherichia coli,BRENDA,ahcys,CHEBI:57856,ahcysns
competitive inhibition,3.2.2.9,,,843,171851,,-,,Escherichia coli,BRENDA,ahcys,CHEBI:57856,ahcysns
"when substrates are cleaved rapidly by dipeptidase, addition of Co2+ inhibits the reaction. The more slowly a substrate is hydrolyzed in the absence of metals, the greater the activating effect",3.4.13.18,C00175,,23,137173,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,amptasecg
,3.4.13.18,,,153,"137173, 137178",,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,amptasecg
"when substrates are cleaved rapidly by dipeptidase, addition of Mn2+ inhibits the reaction. The more slowly a substrate is hydrolyzed in the absence of metals, the greater the activating effect",3.4.13.18,,,11,137173,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,amptasecg
"1 mM, 53% inhibition",3.4.16.4,C00067,,130,650384,,-,Formaldehyde,Escherichia coli,BRENDA,fald,CHEBI:16842,mddcp1pp
,3.5.1.10,,,72,208968,,-,,Escherichia coli,BRENDA,gly,CHEBI:57305,fthfd
product inhibition,3.5.1.16,C00033,,47,171964,,-,Acetate,Escherichia coli,BRENDA,ac,CHEBI:15366,acoda
,3.5.1.16,,,19,171960,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,acoda
,3.5.1.16,,,38,171960,,-,,Escherichia coli,BRENDA,ni2,CHEBI:49786,acoda
product inhibition,3.5.1.16,C00077,,576,171964,,-,L-Ornithine,Escherichia coli,BRENDA,orn,CHEBI:15729,acoda
,3.5.1.16,C00038,,14,171960,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,acoda
no inhibition,3.5.1.25,C00033,,47,246592,,-,Acetate,Escherichia coli,BRENDA,ac,CHEBI:15366,agdc
competitive,3.5.1.25,C00033,,47,246597,,-,Acetate,Escherichia coli,BRENDA,ac,CHEBI:15366,agdc
,3.5.1.25,C00085,,4244,"246592, 246594",,-,D-Fructose 6-phosphate,Escherichia coli,BRENDA,f6p,CHEBI:61553,agdc
,3.5.1.25,C00352,,2841,246592,,-,D-Glucosamine 6-phosphate,Escherichia coli,BRENDA,gam6p,CHEBI:47987,agdc
mixed type inhibition,3.5.1.25,C00352,,2841,246594,,-,D-Glucosamine 6-phosphate,Escherichia coli,BRENDA,gam6p,CHEBI:47987,agdc
substrate inhibition at high concentrations,3.5.1.25,C00357,,1092,246597,,-,N-Acetyl-D-glucosamine 6-phosphate,Escherichia coli,BRENDA,acgam6p,CHEBI:15784,agdc
"0.1 mM, about 65% loss of activity",3.5.1.108,C00038,,14,695538,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,uhgada
,3.5.1.108,C00038,,14,696193,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,uhgada
competitive inhibitor,3.5.3.11,C00062,,532,246681,,-,L-Arginine,Escherichia coli,BRENDA,arg__l,CHEBI:16467,agmt
,3.5.3.11,C00175,,23,246685,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,agmt
,3.5.3.11,,,38,246685,,-,,Escherichia coli,BRENDA,ni2,CHEBI:49786,agmt
noncompetitive inhibitor,3.5.3.11,C00077,,576,246681,,-,L-Ornithine,Escherichia coli,BRENDA,orn,CHEBI:15729,agmt
competitive inhibitor,3.5.3.11,C00134,,155,246676,,-,Putrescine,Escherichia coli,BRENDA,ptrc,CHEBI:17148,agmt
competitive,3.5.3.11,C00134,,155,649495,,-,Putrescine,Escherichia coli,BRENDA,ptrc,CHEBI:17148,agmt
,3.5.3.11,C00134,,155,665940,,-,Putrescine,Escherichia coli,BRENDA,ptrc,CHEBI:17148,agmt
,3.5.3.11,C00038,,14,246685,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,agmt
,3.5.4.1,,,75,209497,,-,,Escherichia coli,BRENDA,ag,CHEBI:49468,csnd
Fe2+CDase,3.5.4.1,,,19,209503,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,csnd
,3.5.4.1,,,19,"209489, 209493, 209497, 209507, 209508",,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,csnd
"only Fe2+CDase, Mn2+CDase, Co2+CDase and Zn2+CDase are not inhibited",3.5.4.1,,,22,209503,,-,,Escherichia coli,BRENDA,h2o2,CHEBI:29192,csnd
,3.5.4.1,C00703,,33,"209489, 209497, 209507, 209508",,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,csnd
,3.5.4.1,C00038,,14,"209489, 209493",,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,csnd
Fe2+CDase,3.5.4.1,C00038,,14,209503,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,csnd
"required, activation at 1-5 mM, inhibitory above",3.5.4.2,,,11,650622,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,add
"4.0 mM, 22% inhibition",3.5.4.5,C00212,,122,209644,,-,Adenosine,Escherichia coli,BRENDA,adn,CHEBI:16335,cytd
,3.5.4.5,C00212,,122,209660,,-,Adenosine,Escherichia coli,BRENDA,adn,CHEBI:16335,cytd
,3.5.4.5,,,19,"209644, 209660, 209661",,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,cytd
"3.0 mM, 32% inhibition",3.5.4.5,C00559,,601,209644,,-,Deoxyadenosine,Escherichia coli,BRENDA,dad_2,CHEBI:17256,cytd
competitive inhibition,3.5.4.5,C00559,,601,"209655, 209658, 209660",,-,Deoxyadenosine,Escherichia coli,BRENDA,dad_2,CHEBI:17256,cytd
,3.5.4.5,C00559,,601,209661,,-,Deoxyadenosine,Escherichia coli,BRENDA,dad_2,CHEBI:17256,cytd
"1.0 mM, 13% inhibition",3.5.4.5,C00330,,732,209644,,-,Deoxyguanosine,Escherichia coli,BRENDA,dgsn,CHEBI:17172,cytd
,3.5.4.5,C00330,,732,209660,,-,Deoxyguanosine,Escherichia coli,BRENDA,dgsn,CHEBI:17172,cytd
"1.0 mM, 32% inhibition",3.5.4.5,C00526,,1060,209644,,-,Deoxyuridine,Escherichia coli,BRENDA,duri,CHEBI:16450,cytd
competitive inhibition,3.5.4.5,C00526,,1060,"209655, 209658, 209660",,-,Deoxyuridine,Escherichia coli,BRENDA,duri,CHEBI:16450,cytd
,3.5.4.5,C14818,,25,"209644, 209660",,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,cytd
,3.5.4.5,C14819,,70,"209644, 209660",,-,Fe3+,Escherichia coli,BRENDA,fe3,CHEBI:29034,cytd
"1.0 mM, 4% inhibition",3.5.4.5,C00387,,296,209644,,-,Guanosine,Escherichia coli,BRENDA,gsn,CHEBI:16750,cytd
,3.5.4.5,C00387,,296,209660,,-,Guanosine,Escherichia coli,BRENDA,gsn,CHEBI:16750,cytd
"4.0 mM, 48% inhibition",3.5.4.5,C16745,,20565,209644,,-,Spongouridine,Escherichia coli,BRENDA,uri,CHEBI:68346,cytd
"above 2 M, reversible inactivation",3.5.4.5,,,116,209644,,-,,Escherichia coli,BRENDA,urea,CHEBI:32285,cytd
"4.0 mM, 20% inhibition",3.5.4.5,C00299,,261,209644,,-,Uridine,Escherichia coli,BRENDA,uri,CHEBI:16704,cytd
product inhibition,3.5.4.5,C00299,,261,"209641, 209645, 209655",,-,Uridine,Escherichia coli,BRENDA,uri,CHEBI:16704,cytd
,3.5.4.5,C00299,,261,"209646, 209648, 209656, 209660, 209661, 209665, 209668, 209669",,-,Uridine,Escherichia coli,BRENDA,uri,CHEBI:16704,cytd
above 10 mM,3.5.4.5,C00038,,14,209644,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,cytd
"inhibits the enzyme in a nonallosterical way, cooperative kinetics are imposed by a dTTP-dependent lag of product formation observed in presteady-state kinetics, the lag may be derived from a slow equilibration between an inactive and an active conformation of dCTP deaminase represented by the dTTP complex and the dUTP/dCTP complex, respectively, steady-state kinetic analysis of dTTP inhibition, overview",3.5.4.13,,,145,686667,,-,,Escherichia coli,BRENDA,dttp,CHEBI:37568,dctpd
competitive inhibitor,3.5.4.16,C00008,,13,209546,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,gtpci
competitive inhibitor,3.5.4.16,C00002,,4,209546,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,gtpci
,3.5.4.16,C00002,,4,"209541, 209549",,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,gtpci
,3.5.4.16,,,19,"209545, 209546, 209553",,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,gtpci
competitive inhibitor,3.5.4.16,C00286,,219,209546,,-,dGTP,Escherichia coli,BRENDA,dgtp,CHEBI:16497,gtpci
,3.5.4.16,C00286,,219,209549,,-,dGTP,Escherichia coli,BRENDA,dgtp,CHEBI:16497,gtpci
,3.5.4.16,C14818,,25,209553,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,gtpci
,3.5.4.16,C00703,,33,"209545, 209546, 209553",,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,gtpci
,3.5.4.16,,,11,209553,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,gtpci
uncompetitive inhibitor,3.5.4.16,C00009,,867,209546,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,gtpci
,3.5.4.16,C00009,,867,"209545, 209549",,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,gtpci
competitive inhibitor,3.5.4.16,,,523,209546,,-,,Escherichia coli,BRENDA,dttp,CHEBI:37568,gtpci
,3.5.4.16,C00075,,65,209541,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,gtpci
competitive inhibitor,3.5.4.16,C00075,,65,209546,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,gtpci
0.1 mM,3.5.4.25,C00013,,17,246729,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,gtpcii2
,3.5.4.25,C00013,,17,"209545, 246730",,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,gtpcii2
competitive inhibitor,3.5.4.25,C00013,,17,246732,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,gtpcii2
competitive,3.5.4.25,C00013,,17,656006,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,gtpcii2
"partial uncompetitive at low concentration, competitive at concentrations above 6 mM",3.5.4.25,C00009,,16,656006,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,gtpcii2
,3.5.99.6,C00085,,87,648239,,-,D-Fructose 6-phosphate,Escherichia coli,BRENDA,f6p,CHEBI:61553,g6pda
tightly bound and slow partial inhibitor,3.5.99.6,C00038,,14,648233,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,g6pda
competes with methylenediphosphonate and diphosphate for binding at the allosteric regulatory site involving Lys112,3.6.1.1,C00002,,4,685299,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,ppa
,3.6.1.1,C01417,,1376,209796,,-,Cyanate,Escherichia coli,BRENDA,cynt,CHEBI:28024,ppa
competes with ATP and methylenediphosphonate for binding at the allosteric regulatory site involving Lys112,3.6.1.1,C00013,,17,685299,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,ppa
competitive with GTP,3.6.1.19,C00002,,4,655847,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,ntpp1
competitive with GTP,3.6.1.19,,,60,655847,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,ntpp1
competitive with GTP,3.6.1.19,C00131,,140,655847,,-,dATP,Escherichia coli,BRENDA,datp,CHEBI:16284,ntpp1
competitive with GTP,3.6.1.19,C00458,,179,655847,,-,dCTP,Escherichia coli,BRENDA,dctp,CHEBI:16311,ntpp1
competitive with GTP,3.6.1.19,C00286,,219,655847,,-,dGTP,Escherichia coli,BRENDA,dgtp,CHEBI:16497,ntpp1
competitive with GTP,3.6.1.19,,,145,655847,,-,,Escherichia coli,BRENDA,dttp,CHEBI:37568,ntpp1
competitive with GTP,3.6.1.19,C00075,,65,655847,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,ntpp1
,3.6.1.21,C00597,,12752,657184,,-,Glycerate 3-phosphate,Escherichia coli,BRENDA,3pg,CHEBI:17050,gdpmnp
,3.6.1.21,C00008,,13,657184,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,gdpmnp
,3.6.1.21,C00020,,30,657184,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,gdpmnp
,3.6.1.21,C00002,,4,657184,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,gdpmnp
,3.6.1.21,C00013,,17,657184,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,gdpmnp
complete inhibition by extensive dialysis against 0.0125 M MgCl2,3.6.1.23,C00305,,6,209964,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,dutpdp
,3.6.1.26,C00008,,13,210004,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,cdappa120
very strong inhibition,3.6.1.26,C00020,,30,210004,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,cdappa120
,3.6.1.26,C00002,,4,210004,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,cdappa120
,3.6.1.26,C00575,,268,210004,,-,"3',5'-Cyclic AMP",Escherichia coli,BRENDA,camp,CHEBI:17489,cdappa120
no inhibition,3.6.1.26,C00055,,100,210004,,-,CMP,Escherichia coli,BRENDA,cmp,CHEBI:17361,cdappa120
,3.6.1.26,C00144,,162,210004,,-,GMP,Escherichia coli,BRENDA,gmp,CHEBI:17345,cdappa120
slight inhibition,3.6.1.26,C00105,,133,210004,,-,UMP,Escherichia coli,BRENDA,ump,CHEBI:16695,cdappa120
"no effect below 0.03 mM, inhibition above",3.6.1.41,,,19,246765,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,ap4ah
"no effect below 0.03 mM, inhibition above",3.6.1.41,C14818,,25,246765,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,ap4ah
"no effect below 0.03 mM, inhibition above",3.6.1.41,C00038,,14,246765,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,ap4ah
exposure prior to the assay,3.6.1.41,C00038,,14,246770,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,ap4ah
competitive,3.6.1.45,C00498,,8036,209944,,-,ADP-glucose,Escherichia coli,BRENDA,adpglc,CHEBI:15751,udpgalppp
"0.074 mM, 21% inhibition",3.6.1.67,C05925,,88310,727800,,-,Dihydroneopterin phosphate,Escherichia coli,BRENDA,dhpmp,CHEBI:48954,dntppa
"1 mM, 89% inhibition",3.6.1.67,C00013,,17,727800,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,dntppa
"1 mM, 72% inhibition",3.6.1.67,,,523,727800,,-,,Escherichia coli,BRENDA,dttp,CHEBI:37568,dntppa
"weak, noncompetitive inhibition",3.6.3.2,,,11,686901,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,mg2uabcpp
in absence of thiolates Cd(II) inhibits above pH 6,3.6.3.5,C01413,,52,246929,,-,Cadmium,Escherichia coli,BRENDA,cd2,CHEBI:48775,zn2abcpp
prevents Zn2+ activation when present in 2fold excess over Zn2+,3.6.3.5,,,19,246928,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,zn2abcpp
,3.6.3.12,C00008,,13,289114,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,kabcpp
,3.6.3.12,C00076,,15,289109,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,kabcpp
,3.6.3.12,C01330,,59,289114,,-,Sodium cation,Escherichia coli,BRENDA,na1,CHEBI:29101,kabcpp
,3.6.3.14,C00008,,13,685315,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,atps4rpp
,3.6.3.14,C00076,,15,210238,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,atps4rpp
location and properties of diphosphate-binding sites,3.6.3.14,C00013,,17,210230,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,atps4rpp
,3.6.3.14,C00703,,33,210238,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,atps4rpp
,3.6.3.14,C00009,,16,210238,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,atps4rpp
substrate inhibition,3.6.3.16,C00002,,4,654492,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,aso3t8pp
98.5% inhibition at 10 mM,3.6.3.20,C00018,,32,718976,,-,Pyridoxal phosphate,Escherichia coli,BRENDA,pydx5p,CHEBI:18405,glyc3pabcpp
inhibits ATPase activity of Pot A,3.6.3.31,C00315,,148,210313,,-,Spermidine,Escherichia coli,BRENDA,spmd,CHEBI:16610,ptrcabcpp
"non competitive to ATP, acting as a feedback inhibitor of the spermidine transport",3.6.3.31,C00315,,148,656055,,-,Spermidine,Escherichia coli,BRENDA,spmd,CHEBI:16610,ptrcabcpp
,4.1.1.8,C00024,,92190,714955,,-,Acetyl-CoA,Escherichia coli,BRENDA,accoa,CHEBI:15351,oxcdc
,4.1.1.8,C00010,,534,714955,,-,CoA,Escherichia coli,BRENDA,coa,CHEBI:15346,oxcdc
,4.1.1.15,C01413,,52,3992,,-,Cadmium,Escherichia coli,BRENDA,cd2,CHEBI:48775,asp1dc
,4.1.1.15,,,19,3992,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,asp1dc
,4.1.1.15,C14818,,25,3992,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,asp1dc
,4.1.1.15,C00703,,33,3992,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,asp1dc
weak,4.1.1.15,C00038,,14,3992,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,asp1dc
,4.1.1.18,C00035,,53,714832,,-,GDP,Escherichia coli,BRENDA,gdp,CHEBI:17552,lysdc
,4.1.1.18,C00044,,37,714832,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,lysdc
addition of ppGpp at low salt concentrations (25-135 mM NaCl depending on the buffer) results in a dramatic inhibition of LdcI activity of about 10fold at pH values higher than 5.0,4.1.1.18,C01228,,3703,714832,,-,"Guanosine 3',5'-bis(diphosphate)",Escherichia coli,BRENDA,ppgpp,CHEBI:17633,lysdc
LdcI activity is strongly inhibited by the binding of ppGpp. The RavA-LdcI interaction reduces the inhibition of LdcI activity by ppGpp in vitro as well as in vivo,4.1.1.18,C01228,,3703,716768,,-,"Guanosine 3',5'-bis(diphosphate)",Escherichia coli,BRENDA,ppgpp,CHEBI:17633,lysdc
inhibits LdcI only at pH values higher than 6.5,4.1.1.18,C04494,,33572,714832,,-,Guanosine 3'-diphosphate 5'-triphosphate,Escherichia coli,BRENDA,gdptp,CHEBI:16690,lysdc
,4.1.1.19,,,75,4090,,-,,Escherichia coli,BRENDA,ag,CHEBI:49468,argdc
,4.1.1.19,C00179,,505,"4085, 4086",,-,Agmatine,Escherichia coli,BRENDA,agm,CHEBI:17431,argdc
L-citrulline,4.1.1.19,,,1464,4085,,-,,Escherichia coli,BRENDA,citr__l,CHEBI:18211,argdc
,4.1.1.19,,,1464,4086,,-,,Escherichia coli,BRENDA,citr__l,CHEBI:18211,argdc
,4.1.1.19,C00062,,100782,4086,,-,L-Arginine,Escherichia coli,BRENDA,arg__l,CHEBI:16467,argdc
,4.1.1.19,C00047,,502,"4085, 4086",,-,L-Lysine,Escherichia coli,BRENDA,lys__l,CHEBI:18019,argdc
L-Orn,4.1.1.19,C00077,,3657,"4085, 4086",,-,L-Ornithine,Escherichia coli,BRENDA,orn,CHEBI:15729,argdc
,4.1.1.19,C00250,,608,4086,,-,Pyridoxal,Escherichia coli,BRENDA,pydx,CHEBI:17310,argdc
,4.1.1.19,C00315,,148,"4085, 4086",,-,Spermidine,Escherichia coli,BRENDA,spmd,CHEBI:16610,argdc
,4.1.1.19,,,116,"4085, 4086",,-,,Escherichia coli,BRENDA,urea,CHEBI:32285,argdc
,4.1.1.20,,,99797,4110,,-,,Escherichia coli,BRENDA,23dappa,CHEBI:58468,dapdc
,4.1.1.20,C00025,,3205,4110,,-,L-Glutamate,Escherichia coli,BRENDA,glu__l,CHEBI:16015,dapdc
,4.1.1.20,C00047,,134,4110,,-,L-Lysine,Escherichia coli,BRENDA,lys__l,CHEBI:18019,dapdc
reversed by diaminoheptanedioate addition,4.1.1.20,C00047,,134,4127,,-,L-Lysine,Escherichia coli,BRENDA,lys__l,CHEBI:18019,dapdc
weak inhibitor,4.1.1.23,C00105,,133,649973,,-,UMP,Escherichia coli,BRENDA,ump,CHEBI:16695,ompdc
,4.1.1.23,C00655,,6701,694055,,-,Xanthosine 5'-phosphate,Escherichia coli,BRENDA,xmp,CHEBI:15652,ompdc
,4.1.1.31,C00049,,304,"4308, 4311, 657356",,-,L-Aspartate,Escherichia coli,BRENDA,asp__l,CHEBI:17053,ppc
,4.1.1.31,,,131,4311,,-,,Escherichia coli,BRENDA,cit,CHEBI:76049,ppc
,4.1.1.31,,,553,4311,,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,ppc
,4.1.1.31,C00122,,170,4311,,-,Fumarate,Escherichia coli,BRENDA,fum,CHEBI:18012,ppc
,4.1.1.31,C00042,,58,4311,,-,Succinate,Escherichia coli,BRENDA,succ,CHEBI:15741,ppc
,4.1.1.36,C00250,,608,4415,,-,Pyridoxal,Escherichia coli,BRENDA,pydx,CHEBI:17310,ppcdc
,4.1.1.36,C00018,,32,4415,,-,Pyridoxal phosphate,Escherichia coli,BRENDA,pydx5p,CHEBI:18405,ppcdc
the presence of 9.6 mM ATP decreases 3folds the catalytic efficiency of the enzyme,4.1.1.49,C00002,,4,727382,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,ppck
,4.1.1.49,C00354,,106,649304,,-,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,ppck
,4.1.1.49,C00085,,87,649304,,-,D-Fructose 6-phosphate,Escherichia coli,BRENDA,f6p,CHEBI:61553,ppck
,4.1.1.49,C00111,,278,649304,,-,Glycerone phosphate,Escherichia coli,BRENDA,dhap,CHEBI:16108,ppck
,4.1.1.49,C00597,,2742,649304,,-,Glycerate 3-phosphate,Escherichia coli,BRENDA,3pg,CHEBI:17050,ppck
,4.1.1.49,C00305,,6,649304,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,ppck
,4.1.1.49,C00004,,8,4621,,-,NADH,Escherichia coli,BRENDA,nadh,CHEBI:16908,ppck
competitive inhibitor,4.1.1.49,C00209,,185,650420,,-,Oxalate,Escherichia coli,BRENDA,oxa,CHEBI:16995,ppck
,4.1.1.50,C01137,,7304,4668,,-,S-Adenosylmethioninamine,Escherichia coli,BRENDA,ametam,CHEBI:15625,admdc
competitive with respect to S-adenosylmethionine,4.1.1.50,C01137,,7304,4672,,-,S-Adenosylmethioninamine,Escherichia coli,BRENDA,ametam,CHEBI:15625,admdc
,4.1.1.50,C01326,,159,"4680, 4681",,-,Hydrogen cyanide,Escherichia coli,BRENDA,cyan,CHEBI:18407,admdc
"substrate inactivation results in the conversion of the pyruvoyl group to an alanyl residue. The mechanism of inactivation involves the transamination of the nascent product to the pyruvoyl group, followed by the elimination of methylthioadenosine and the generation of a 2-propenal equivalent which can undergo a Michael addition to the enzyme",4.1.1.50,C00019,,24,4660,,-,S-Adenosyl-L-methionine,Escherichia coli,BRENDA,amet,CHEBI:15414,admdc
binding structure involving Glu33 and Asp62 and Mg2+,4.1.1.85,,,125196,650143,,-,,Escherichia coli,BRENDA,6pgc,CHEBI:43824,kg6pdc
,4.1.2.4,C00479,,273,5172,,-,Propanal,Escherichia coli,BRENDA,ppal,CHEBI:17153,drpa
,4.1.2.13,C00597,,194,4943,,-,Glycerate 3-phosphate,Escherichia coli,BRENDA,3pg,CHEBI:17050,fba
,4.1.2.13,,,553,4913,,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,fba
,4.1.2.13,C00111,,278,652787,,-,Glycerone phosphate,Escherichia coli,BRENDA,dhap,CHEBI:16108,fba
,4.1.2.13,C00013,,17,4943,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,fba
,4.1.2.13,C00661,,574,4943,,-,Glyceraldehyde 3-phosphate,Escherichia coli,BRENDA,g3p,CHEBI:17138,fba
non-competitive inhibitor,4.1.2.13,C00661,,574,652787,,-,Glyceraldehyde 3-phosphate,Escherichia coli,BRENDA,g3p,CHEBI:17138,fba
,4.1.2.13,C00111,,482,4943,,-,Glycerone phosphate,Escherichia coli,BRENDA,dhap,CHEBI:16108,fba
"cells stressed by 8 microM Ni(II) for 20 min lose 75% of their FbaA activity. In presence of 8 microM Ni(II), purified FbaA loses 80% of its activity within 2 min. Inhibition is due to Ni(II) binding to a secondary zinc binding site",4.1.2.13,,,38,728325,,-,,Escherichia coli,BRENDA,ni2,CHEBI:49786,fba
competitive inhibition,4.1.2.17,C00546,,322,690787,,-,Methylglyoxal,Escherichia coli,BRENDA,mthgxl,CHEBI:17158,fclpa
"inhibitory effect of Zn2+ on his-tagged enzyme, but not on the native enzyme",4.1.2.17,C00038,,14,679548,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,fclpa
"1 mM, 50% inhibition",4.1.2.19,C00175,,23,5065,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,rmpa
,4.1.2.19,C00175,,23,5067,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,rmpa
"5 mM, 95% inhibition",4.1.2.19,,,38,5065,,-,,Escherichia coli,BRENDA,ni2,CHEBI:49786,rmpa
,4.1.2.19,,,38,5067,,-,,Escherichia coli,BRENDA,ni2,CHEBI:49786,rmpa
the aldol addition of dihydroxyacetobe is strongly inhibited by phosphate,4.1.2.19,C00009,,16,713694,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,rmpa
,4.1.2.19,C00059,,160,713694,,-,Sulfate,Escherichia coli,BRENDA,so4,CHEBI:26836,rmpa
"reversed by Mg2+ and Co2+, but not by Fe2+",4.1.2.20,C01326,,159,5078,,-,Hydrogen cyanide,Escherichia coli,BRENDA,cyan,CHEBI:18407,glcral
,4.1.2.20,C00013,,17,5078,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,glcral
competitive,4.1.2.25,C01300,,7091,"5103, 5104",,-,"2-Amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine",Escherichia coli,BRENDA,6hmhpt,CHEBI:44841,dhnpa2r
slight,4.1.2.25,C00415,,8093,5103,,-,Dihydrofolate,Escherichia coli,BRENDA,dhf,CHEBI:15633,dhnpa2r
,4.1.2.25,C00415,,8093,5104,,-,Dihydrofolate,Escherichia coli,BRENDA,dhf,CHEBI:15633,dhnpa2r
slight,4.1.2.25,C00921,,12509,"5103, 5104",,-,Dihydropteroate,Escherichia coli,BRENDA,dhpt,CHEBI:4581,dhnpa2r
,4.1.3.1,C00026,,34,33118,,-,2-Oxoglutarate,Escherichia coli,BRENDA,akg,CHEBI:30915,icl
,4.1.3.1,C00597,,194,33118,,-,Glycerate 3-phosphate,Escherichia coli,BRENDA,3pg,CHEBI:17050,icl
,4.1.3.1,C00076,,15,33117,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,icl
,4.1.3.1,C01327,,141,33118,,-,Hydrochloric acid,Escherichia coli,BRENDA,cl,CHEBI:17883,icl
50% inhibition at 5 mM,4.1.3.1,C00160,,479,33117,,-,Glycolate,Escherichia coli,BRENDA,glyclt,CHEBI:17497,icl
,4.1.3.1,C00160,,479,33118,,-,Glycolate,Escherichia coli,BRENDA,glyclt,CHEBI:17497,icl
linear competitive inhibitor,4.1.3.1,C00048,,101,33156,,-,Glyoxylate,Escherichia coli,BRENDA,glx,CHEBI:16891,icl
,4.1.3.1,C00209,,185,33117,,-,Oxalate,Escherichia coli,BRENDA,oxa,CHEBI:16995,icl
,4.1.3.1,C00009,,16,33118,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,icl
,4.1.3.1,C00074,,51,33118,,-,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,icl
uncompetitive inhibitor,4.1.3.1,C00074,,51,680481,,-,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,icl
,4.1.3.1,C00059,,245,33118,,-,Sulfate,Escherichia coli,BRENDA,so4,CHEBI:26836,icl
,4.1.3.1,C00042,,58,"33117, 33118",,-,Succinate,Escherichia coli,BRENDA,succ,CHEBI:15741,icl
"0% residual activity at 0.1 mM, 6% residual activity at 0.01 mM",4.1.3.3,,,75,33314,,-,,Escherichia coli,BRENDA,ag,CHEBI:49468,acnml
"37% residual activity at 1 mM, 89% residual activity at 0.1 mM",4.1.3.3,,,19,33314,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,acnml
7% residual activity at 1 mM,4.1.3.3,,,19,33332,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,acnml
,4.1.3.3,,,19,33337,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,acnml
2% residual activity at 10 mM,4.1.3.3,C00184,,620,33332,,-,Glycerone,Escherichia coli,BRENDA,dha,CHEBI:16016,acnml
78% residual activity at 1 mM,4.1.3.3,C14818,,25,33332,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,acnml
"0% residual activity at 0.1 mM, 22% residual activity at 0.01 mM",4.1.3.3,C00703,,33,33314,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,acnml
,4.1.3.3,C00703,,33,33337,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,acnml
"0% residual activity at 10 mM, 16% residual activity at 1 mM",4.1.3.3,,,1126,33314,,-,,Escherichia coli,BRENDA,h2o2,CHEBI:29192,acnml
20% residual activity at 10 mM,4.1.3.3,,,11,33337,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,acnml
elimination,4.1.3.3,C00022,,31,33314,,-,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,acnml
30% residual activity at 10 mM,4.1.3.3,C00022,,31,33332,,-,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,acnml
1% residual activity at 10 mM,4.1.3.3,C00038,,14,33337,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,acnml
irreversible,4.1.3.6,C00036,,57,"33352, 33363",,-,Oxaloacetate,Escherichia coli,BRENDA,oaa,CHEBI:30744,citl
,4.1.3.27,,,420,33276,,-,,Escherichia coli,BRENDA,trp__l,CHEBI:57912,ans
"strain with a anthanilate synthase that is insensitive to feedback inhibition by Trp, the 61st nucleotide, C to A substitution, that changes Pro21 to Ser is the cause of the desensitization to feedback inhibition by Trp",4.1.3.27,,,420,33310,,-,,Escherichia coli,BRENDA,trp__l,CHEBI:57912,ans
,4.1.3.27,C00156,,3660,650373,,-,4-Hydroxybenzoate,Escherichia coli,BRENDA,4hbz,CHEBI:30763,ans
,4.1.3.39,C00109,,3288,702377,,-,2-Oxobutanoate,Escherichia coli,BRENDA,2obut,CHEBI:30831,hopntal
,4.1.3.39,C00233,,722,702377,,-,4-Methyl-2-oxopentanoate,Escherichia coli,BRENDA,4mop,CHEBI:48430,hopntal
,4.1.3.39,C00048,,101,702377,,-,Glyoxylate,Escherichia coli,BRENDA,glx,CHEBI:16891,hopntal
,4.1.3.39,C00022,,31,702377,,-,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,hopntal
product inhibition,4.1.3.40,C00156,,365,650373,,-,4-Hydroxybenzoate,Escherichia coli,BRENDA,4hbz,CHEBI:30763,chrpl
competitive,4.1.99.1,,,369,37334,,-,,Escherichia coli,BRENDA,ala__l,CHEBI:57972,trpas2
competitive; L-Ala,4.1.99.1,,,369,37339,,-,,Escherichia coli,BRENDA,ala__l,CHEBI:57972,trpas2
L-Ala,4.1.99.1,,,369,37344,,-,,Escherichia coli,BRENDA,ala__l,CHEBI:57972,trpas2
,4.1.99.1,,,369,"37354, 37364",,-,,Escherichia coli,BRENDA,ala__l,CHEBI:57972,trpas2
,4.1.99.1,,,103,651028,,-,,Escherichia coli,BRENDA,ala__l,CHEBI:57972,trpas2
competitive,4.1.99.1,,,468,664076,,-,,Escherichia coli,BRENDA,met__l,CHEBI:57844,trpas2
,4.1.99.1,C00073,,88,651028,,-,L-Methionine,Escherichia coli,BRENDA,met__l,CHEBI:16643,trpas2
,4.1.99.1,,,104,651028,,-,,Escherichia coli,BRENDA,phe__l,CHEBI:58095,trpas2
competitive with S-o-nitrophenyl-L-Cys,4.1.99.1,,,420,37364,,-,,Escherichia coli,BRENDA,trp__l,CHEBI:57912,trpas2
,4.1.99.1,,,420,665767,,-,,Escherichia coli,BRENDA,trp__l,CHEBI:57912,trpas2
,4.1.99.1,,,119,651028,,-,,Escherichia coli,BRENDA,trp__l,CHEBI:57912,trpas2
,4.1.99.1,,,678,37341,,-,,Escherichia coli,BRENDA,met__l,CHEBI:57844,trpas2
,4.1.99.1,,,379,"37341, 37354",,-,,Escherichia coli,BRENDA,phe__l,CHEBI:58095,trpas2
,4.2.1.2,C00898,,42777,33771,,-,"(R,R)-Tartaric acid",Escherichia coli,BRENDA,tartr__l,CHEBI:15671,fum
,4.2.1.2,C00417,,1230,33771,,-,cis-Aconitate,Escherichia coli,BRENDA,acon_c,CHEBI:32805,fum
,4.2.1.2,,,131,33771,,-,,Escherichia coli,BRENDA,cit,CHEBI:76049,fum
wild-type enzyme is inhibited due to a viscogenic effect on the recycling rate,4.2.1.2,C00116,,135,653600,,-,Glycerol,Escherichia coli,BRENDA,glyc,CHEBI:17754,fum
,4.2.1.2,C02341,,2874,33771,,-,trans-Aconitate,Escherichia coli,BRENDA,acon_t,CHEBI:32806,fum
weak,4.2.1.7,C00818,,2195,5900,,-,D-Glucarate,Escherichia coli,BRENDA,glcr,CHEBI:16002,altrh
"low concentrations required, inhibition above 2 mM",4.2.1.7,C14818,,25,5901,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,altrh
CuSO4,4.2.1.9,,,19,33959,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,dhad1
nitric oxide halts bacterial growth via inhibition of the branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase,4.2.1.9,C00533,,662,682577,,-,Nitric oxide,Escherichia coli,BRENDA,no,CHEBI:16480,dhad1
"IlvD is completely inactivated in cells by NO with the concomitant formation of the IlvD-bound dinitrosyl iron complex, DNIC. While the IlvD-bound DNIC and other protein-bound DNICs are stable in cells under anaerobic growth conditions, they are efficiently repaired under aerobic growth conditions even without new protein synthesis, L-cysteine plays an important role, overview",4.2.1.9,C00533,,277,700277,,-,Nitric oxide,Escherichia coli,BRENDA,no,CHEBI:16480,dhad1
,4.2.1.10,C00033,,47,"5473, 5474",,-,Acetate,Escherichia coli,BRENDA,ac,CHEBI:15366,dhqti
,4.2.1.10,C01327,,141,"5473, 5474",,-,Hydrochloric acid,Escherichia coli,BRENDA,cl,CHEBI:17883,dhqti
partial,4.2.1.10,,,19,5463,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,dhqti
,4.2.1.10,C02107,,96321,5473,,-,"(S,S)-Tartaric acid",Escherichia coli,BRENDA,tartr__d,CHEBI:15672,dhqti
partial,4.2.1.10,C14818,,25,5463,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,dhqti
,4.2.1.10,C00042,,58,"5473, 5474",,-,Succinate,Escherichia coli,BRENDA,succ,CHEBI:15741,dhqti
partial,4.2.1.10,C00038,,14,5463,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,dhqti
the enzyme is much less sensitive to O2 or H2O2 than to O2-,4.2.1.12,,,22,33658,,-,,Escherichia coli,BRENDA,h2o2,CHEBI:29192,edd
the enzyme is much less sensitive to O2 or H2O2 than to O2-,4.2.1.12,,,9,33658,,-,,Escherichia coli,BRENDA,o2,CHEBI:27140,edd
,4.2.1.24,C00031,,35,691351,,-,D-Glucose,Escherichia coli,BRENDA,glc__d,CHEBI:4167,ppbngs
,4.2.1.24,C00181,,115,691351,,-,D-Xylose,Escherichia coli,BRENDA,xyl__d,CHEBI:53455,ppbngs
high concentrations,4.2.1.40,C00175,,23,33840,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,glcrd
,4.2.1.40,C00879,,30007,33840,,-,D-Galactarate,Escherichia coli,BRENDA,galct__d,CHEBI:30852,glcrd
high concentrations,4.2.1.40,,,11,33840,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,glcrd
,4.2.1.42,,,131,5701,,-,,Escherichia coli,BRENDA,cit,CHEBI:76049,galctd
,4.2.1.42,C00013,,17,5701,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,galctd
,4.2.1.42,C00009,,16,5701,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,galctd
irreversible,4.2.1.46,,,75,5718,,-,,Escherichia coli,BRENDA,ag,CHEBI:49468,tdpgdh
,4.2.1.46,C00363,,694,5714,,-,dTDP,Escherichia coli,BRENDA,dtdp,CHEBI:18075,tdpgdh
,4.2.1.46,,,523,5714,,-,,Escherichia coli,BRENDA,dttp,CHEBI:37568,tdpgdh
no inhibition,4.2.1.47,C00035,,53,5733,,-,GDP,Escherichia coli,BRENDA,gdp,CHEBI:17552,gmand
,4.2.1.47,C00325,,282,5732,,-,GDP-L-fucose,Escherichia coli,BRENDA,gdpfuc,CHEBI:13332,gmand
up to 73% inhibition,4.2.1.47,C00325,,282,5733,,-,GDP-L-fucose,Escherichia coli,BRENDA,gdpfuc,CHEBI:13332,gmand
"marked inhibition at 5 mM, abolished by 60 mM Mg2+",4.2.3.1,,,30785,137551,,-,,Escherichia coli,BRENDA,4hthr,CHEBI:60904,4hthrs
Ki: 0.006 mM,4.2.3.1,,,30785,137559,,-,,Escherichia coli,BRENDA,4hthr,CHEBI:60904,4hthrs
,4.2.3.3,,,750,137616,,-,,Escherichia coli,BRENDA,2pg,CHEBI:24344,mgsa
inhibits,4.2.3.3,C00988,,1317,649962,,-,2-Phosphoglycolate,Escherichia coli,BRENDA,2pglyc,CHEBI:17150,mgsa
,4.2.3.3,C00597,,194,"137600, 137601",,-,Glycerate 3-phosphate,Escherichia coli,BRENDA,3pg,CHEBI:17050,mgsa
,4.2.3.3,C01478,,255,137601,,-,Arsenic acid,Escherichia coli,BRENDA,aso4,CHEBI:18231,mgsa
,4.2.3.3,C00013,,17,"137600, 137601",,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,mgsa
,4.2.3.3,C00009,,16,"137600, 137601",,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,mgsa
alosteric inhibitor,4.2.3.3,C00009,,16,653942,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,mgsa
,4.2.3.3,C00074,,51,"137600, 137601",,-,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,mgsa
,4.2.3.4,C04691,,45157,137619,,-,2-Dehydro-3-deoxy-D-arabino-heptonate 7-phosphate,Escherichia coli,BRENDA,2dda7p,CHEBI:18150,dhqs
,4.2.3.5,C14818,,25,137655,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,chors
i.e. aspartic beta-semialdehyde.Inactivates as an active-site directed agent,4.3.1.1,C00441,,43798,6009,,-,L-Aspartate 4-semialdehyde,Escherichia coli,BRENDA,aspsa,CHEBI:18051,aspt
,4.3.1.1,C00441,,43798,6028,,-,L-Aspartate 4-semialdehyde,Escherichia coli,BRENDA,aspsa,CHEBI:18051,aspt
,4.3.1.1,C00497,,1139,"6016, 649266",,-,(R)-Malate,Escherichia coli,BRENDA,mal__d,CHEBI:30796,aspt
nonspecific,4.3.1.1,C11143,,1217,6019,,-,Dimethyl sulfoxide,Escherichia coli,BRENDA,dmso,CHEBI:28262,aspt
"moderate, nonspecific",4.3.1.1,C00469,,69,6019,,-,Ethanol,Escherichia coli,BRENDA,etoh,CHEBI:16236,aspt
,4.3.1.1,C00149,,247,6016,,-,(S)-Malate,Escherichia coli,BRENDA,mal__l,CHEBI:30797,aspt
"moderate, nonspecific",4.3.1.1,C00132,,83,6019,,-,Methanol,Escherichia coli,BRENDA,meoh,CHEBI:17790,aspt
weak,4.3.1.1,C01330,,59,5998,,-,Sodium cation,Escherichia coli,BRENDA,na1,CHEBI:29101,aspt
competitive,4.3.1.1,C01005,,1189,6028,,-,O-Phospho-L-serine,Escherichia coli,BRENDA,pser__l,CHEBI:15811,aspt
,4.3.1.1,C00988,,1798,6016,,-,2-Phosphoglycolate,Escherichia coli,BRENDA,2pglyc,CHEBI:17150,aspt
,4.3.1.1,C00042,,58,6016,,-,Succinate,Escherichia coli,BRENDA,succ,CHEBI:15741,aspt
competitive,4.3.1.1,C00042,,58,"6000, 6019",,-,Succinate,Escherichia coli,BRENDA,succ,CHEBI:15741,aspt
competitive,4.3.1.7,C05771,,29958,34382,,-,1-Aminopropan-2-ol,Escherichia coli,BRENDA,appl,CHEBI:19030,ethaal
above 1 mM,4.3.1.7,,,116,34382,,-,,Escherichia coli,BRENDA,urea,CHEBI:32285,ethaal
,4.3.1.18,,,369,210805,,-,,Escherichia coli,BRENDA,ala__l,CHEBI:57972,serd_d
,4.3.1.18,,,29959,651969,,-,,Escherichia coli,BRENDA,23dappa,CHEBI:58468,serd_d
,4.3.1.18,,,163,210805,,-,,Escherichia coli,BRENDA,gly,CHEBI:57305,serd_d
,4.3.1.18,,,72,651969,,-,,Escherichia coli,BRENDA,gly,CHEBI:57305,serd_d
,4.3.1.18,,,9192,651969,,-,,Escherichia coli,BRENDA,23dappa,CHEBI:57721,serd_d
,4.3.1.18,,,103,651969,,-,,Escherichia coli,BRENDA,ala__l,CHEBI:57972,serd_d
,4.3.1.18,,,95,651969,,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,serd_d
"competitive allosteric inhibitor, the enzyme exists in two distinct catalytically active species: a tetramer sensitive to L-Ile inhibition and a dimer insensitive to L-Ile inhibition",4.3.1.19,,,1088,210840,,-,,Escherichia coli,BRENDA,ile__l,CHEBI:58045,serd_l
negative allosteric effector,4.3.1.19,,,1088,210856,,-,,Escherichia coli,BRENDA,ile__l,CHEBI:58045,serd_l
biodegradative enzyme is feedback-resistant,4.3.1.19,,,1088,210857,,-,,Escherichia coli,BRENDA,ile__l,CHEBI:58045,serd_l
,4.3.1.19,,,1088,210863,,-,,Escherichia coli,BRENDA,ile__l,CHEBI:58045,serd_l
inhibition of isoleucine can be reversed by valine,4.3.1.19,,,1088,729066,,-,,Escherichia coli,BRENDA,ile__l,CHEBI:58045,serd_l
feedback inhibition,4.3.1.19,,,1028,653575,,-,,Escherichia coli,BRENDA,ile__l,CHEBI:58045,serd_l
"uncompetitive inhibition and substrate inhibition with respect to L-Thr, noncompetitive inhibition with respect to AMP",4.3.1.19,C00022,,31,210823,,-,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,serd_l
,4.3.1.19,C00022,,31,210847,,-,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,serd_l
competitive with L-cystathionine,4.4.1.8,,,553,34690,,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,cysds
mixed type inhibition,4.4.1.15,,,74,648731,,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,cysdds
,4.4.1.15,C00038,,14,648731,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,cysdds
,4.6.1.1,C00008,,13,34764,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,adncyc
high concentrations,4.6.1.1,C00002,,4,34764,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,adncyc
,4.6.1.1,C00076,,15,"34764, 34790",,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,adncyc
high concentrations,4.6.1.1,C00175,,23,"34764, 34790",,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,adncyc
,4.6.1.1,C00013,,17,"34764, 34770, 34790",,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,adncyc
,4.6.1.1,C00044,,37,"34764, 34813",,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,adncyc
,4.6.1.1,C00018,,32,"34790, 34813",,-,Pyridoxal phosphate,Escherichia coli,BRENDA,pydx5p,CHEBI:18405,adncyc
,4.6.1.1,C00038,,14,34790,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,adncyc
"the native enzyme is completely insensitive to inhibition, the desensitized enzyme is strongly inhibited. Desensitization by heat converts the enzyme to its ultimate catalytic form",5.1.3.2,C00105,,915,2320,,-,UMP,Escherichia coli,BRENDA,ump,CHEBI:16695,udpg4e
reductive inhibition,5.1.3.2,C00842,,91858,2320,,-,dTDP-glucose,Escherichia coli,BRENDA,dtdpglu,CHEBI:15700,udpg4e
,5.1.3.2,C00004,,8,2320,,-,NADH,Escherichia coli,BRENDA,nadh,CHEBI:16908,udpg4e
"NADH associated with the purified enzyme is a component of the inactive, abortive complexes, enzyme-NADH-uridine nucleotide, that contain tightly bound uridine nucleotides in place of the epimerization intermediate UDP-4-keto-alpha-D-hexoglucopyranose. These complexes are produced in vivo in the course of bacterial growth",5.1.3.2,C00004,,8,2332,,-,NADH,Escherichia coli,BRENDA,nadh,CHEBI:16908,udpg4e
,5.1.3.4,C00266,,604,2396,,-,Glycolaldehyde,Escherichia coli,BRENDA,gcald,CHEBI:17071,rbp4e
,5.1.3.20,C00008,,13,2357,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,agmhe
,5.1.3.20,C00498,,598,653940,,-,ADP-glucose,Escherichia coli,BRENDA,adpglc,CHEBI:15751,agmhe
,5.1.3.20,C00498,,1112,2357,,-,ADP-glucose,Escherichia coli,BRENDA,adpglc,CHEBI:15751,agmhe
,5.1.3.20,C00002,,4,2357,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,agmhe
,5.1.3.20,C00004,,8,2357,,-,NADH,Escherichia coli,BRENDA,nadh,CHEBI:16908,agmhe
,5.3.1.1,C00988,,1317,2586,,-,2-Phosphoglycolate,Escherichia coli,BRENDA,2pglyc,CHEBI:17150,tpi
,5.3.1.3,C01413,,52,2684,,-,Cadmium,Escherichia coli,BRENDA,cd2,CHEBI:48775,fci
"essential for catalysis, but also competitive inhibitor for L-arabinose",5.3.1.4,,,11,2729,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,arai
"suppressed enzyme synthesis by increased content from 0.1 to 1.5%, productivity maxima at 0.1%, if D-xylose is the carbon source: D-glucose supplementation suppresses formation of xylose isomerase",5.3.1.5,C00031,,35,671399,,-,D-Glucose,Escherichia coli,BRENDA,glc__d,CHEBI:4167,xyli1
,5.3.1.6,C00345,,391,2787,,-,6-Phospho-D-gluconate,Escherichia coli,BRENDA,6pgc,CHEBI:48928,rpi
,5.3.1.6,C00020,,30,2787,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,rpi
,5.3.1.6,C01112,,6486,653911,,-,D-Arabinose 5-phosphate,Escherichia coli,BRENDA,ara5p,CHEBI:16241,rpi
,5.3.1.6,C00085,,453,2787,,-,D-Fructose 6-phosphate,Escherichia coli,BRENDA,f6p,CHEBI:61553,rpi
,5.3.1.6,C00009,,16,653911,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,rpi
,5.3.1.8,C00644,,5992,660706,,-,D-Mannitol 1-phosphate,Escherichia coli,BRENDA,mnl1p,CHEBI:16298,man6pi
,5.3.1.9,C00345,,391,"2624, 2841",,-,6-Phospho-D-gluconate,Escherichia coli,BRENDA,6pgc,CHEBI:48928,pgi
,5.3.1.12,,,19,2619,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,gui1
,5.3.1.12,,,153,2619,,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,gui1
,5.3.1.12,C00038,,14,2619,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,gui1
"0.01 mM, complete inhibition",5.3.1.13,C01413,,52,652445,,-,Cadmium,Escherichia coli,BRENDA,cd2,CHEBI:48775,a5piso
"0.01 mM, significant inhibition",5.3.1.13,C01413,,52,660993,,-,Cadmium,Escherichia coli,BRENDA,cd2,CHEBI:48775,a5piso
,5.3.1.13,C01413,,52,671856,,-,Cadmium,Escherichia coli,BRENDA,cd2,CHEBI:48775,a5piso
,5.3.1.13,C01413,,52,"2624, 715380",,-,Cadmium,Escherichia coli,BRENDA,cd2,CHEBI:48775,a5piso
,5.3.1.13,C00175,,23,2624,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,a5piso
,5.3.1.13,,,19,652445,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,a5piso
,5.3.1.13,,,19,671856,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,a5piso
best inhibitor,5.3.1.13,C03393,,93343,2625,,-,4-Phospho-D-erythronate,Escherichia coli,BRENDA,4per,CHEBI:49003,a5piso
"0.01 mM, complete inhibition",5.3.1.13,C00703,,33,652445,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,a5piso
"0.01 mM, significant inhibition",5.3.1.13,C00703,,33,660993,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,a5piso
,5.3.1.13,C00703,,33,671856,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,a5piso
,5.3.1.13,C00703,,33,715380,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,a5piso
,5.3.1.13,,,11,2624,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,a5piso
,5.3.1.13,,,38,652445,,-,,Escherichia coli,BRENDA,ni2,CHEBI:49786,a5piso
"; 0.01 mM, complete inhibition, IC50: 0.001-0.003 mM",5.3.1.13,C00038,,14,652445,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,a5piso
"0.01 mM, significant inhibition",5.3.1.13,C00038,,14,660993,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,a5piso
0.01 mM,5.3.1.13,C00038,,14,662042,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,a5piso
,5.3.1.13,C00038,,14,671856,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,a5piso
inhibits substrate binding by the enzyme in a reversible manner,5.3.1.13,C00038,,14,701812,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,a5piso
Zn2+ inhibits substrate binding in a reversible manner,5.3.1.13,C00038,,14,714743,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,a5piso
,5.3.1.13,C00038,,14,"2624, 715380",,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,a5piso
product inhibition,5.3.1.24,C01302,,1250,4611,,-,1-(2-Carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate,Escherichia coli,BRENDA,2cpr5p,CHEBI:29112,praii
in presence of 0.2 mM CoCl2,5.4.2.7,C00076,,15,3340,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,ppm2
in presence of 0.2 mM CoCl2,5.4.2.7,C01413,,52,3340,,-,Cadmium,Escherichia coli,BRENDA,cd2,CHEBI:48775,ppm2
in presence of 0.2 mM CoCl2,5.4.2.7,,,19,3340,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,ppm2
in presence of 0.2 mM CoCl2,5.4.2.7,C14819,,70,3340,,-,Fe3+,Escherichia coli,BRENDA,fe3,CHEBI:29034,ppm2
"50 mM, 95% inhibition",5.4.2.7,C00009,,16,3340,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,ppm2
"50 mM, 85% inhibition",5.4.2.7,C00059,,245,3340,,-,Sulfate,Escherichia coli,BRENDA,so4,CHEBI:26836,ppm2
in presence of 0.2 mM CoCl2,5.4.2.7,C00038,,14,3340,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,ppm2
80% reduced activity,5.4.2.10,C00076,,15,210870,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,pgamt
80% reduced activity,5.4.2.10,,,11,210870,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,pgamt
"efficient autophosphorylation, but absence of catalytic activity",5.4.2.10,C00038,,14,210870,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,pgamt
,5.4.99.5,,,203,"3535, 3543, 3564, 3574",,-,,Escherichia coli,BRENDA,phe__l,CHEBI:58095,chorm
,5.4.99.5,,,415,"3535, 3557, 3564",,-,,Escherichia coli,BRENDA,tyr__l,CHEBI:58315,chorm
competitive,5.4.99.5,C00254,,353,3574,,-,Prephenate,Escherichia coli,BRENDA,pphn,CHEBI:84387,chorm
competitive inhibition,5.4.99.5,C00254,,353,390552,,-,Prephenate,Escherichia coli,BRENDA,pphn,CHEBI:84387,chorm
inhibition is weakened by chloride,6.1.1.1,C00020,,30,650300,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,tyrtrs
"inhibition in presence of 1 mM free Mg2+, no inhibition in presence of 10 mM free Mg2+",6.1.1.1,C01327,,298,650300,,-,Hydrochloric acid,Escherichia coli,BRENDA,cl,CHEBI:17883,tyrtrs
inhibition is strengthened by chloride,6.1.1.1,C00013,,17,650300,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,tyrtrs
inhibition in presence of 1 mM free Mg2+,6.1.1.1,C00059,,160,650300,,-,Sulfate,Escherichia coli,BRENDA,so4,CHEBI:26836,tyrtrs
"oxidizes cysteine182 residue critical for editing, which leads to Ser-tRNAThr formation and protein mistranslation that impaired growth of Escherichia coli. Presence of major heat shock proteases is required to allow cell growth in medium containing serine and hydrogen peroxide, which suggests that the mistranslated proteins are misfolded",6.1.1.3,,,1126,716771,,-,,Escherichia coli,BRENDA,h2o2,CHEBI:29192,thrtrs
inhibits the editing reaction,6.1.1.3,C00038,,14,662829,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,thrtrs
,6.1.1.4,C00131,,2704,429,,-,dATP,Escherichia coli,BRENDA,datp,CHEBI:16284,leutrs
,6.1.1.4,C00212,,122,429,,-,Adenosine,Escherichia coli,BRENDA,adn,CHEBI:16335,leutrs
,6.1.1.4,C00008,,13,429,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,leutrs
,6.1.1.4,C00020,,30,429,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,leutrs
,6.1.1.4,C00081,,229,429,,-,ITP,Escherichia coli,BRENDA,itp,CHEBI:16039,leutrs
partly inhibits the binding of tRNA,6.1.1.5,C00013,,17,454,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,iletrs
,6.1.1.6,C01672,,533,652528,,-,Cadaverine,Escherichia coli,BRENDA,15dap,CHEBI:18127,lystrs
"synthesis of lysyl-tRNA from lysyl-AMP-enzyme inhibited, formation of Lys-tRNALys from lysine, tRNA and ATP-enzyme complex or ATP is dependent on Mg2+",6.1.1.6,C00305,,6,484,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,lystrs
competitive versus L-lysine,6.1.1.6,C00077,,576,652528,,-,L-Ornithine,Escherichia coli,BRENDA,orn,CHEBI:15729,lystrs
,6.1.1.6,C00038,,14,674885,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,lystrs
"denaturation at 3.3 M, the Zn2+-depleted enzyme is much more sensitive to denaturation by urea than the native enzyme",6.1.1.7,,,116,649422,,-,,Escherichia coli,BRENDA,urea,CHEBI:32285,alatrs
"maximal inhibition at MgCl2 concentration from 4.0 mM to 10 mM, effective inhibition at high concentration of diphosphate",6.1.1.10,C00212,,122,34,,-,Adenosine,Escherichia coli,BRENDA,adn,CHEBI:16335,mettrs
,6.1.1.11,C00013,,17,84,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,sertrs
inhibits deacylation of Cys-tRNACys,6.1.1.16,,,153,181,,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,cystrs
,6.1.1.19,C00002,,90970,280,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,argtrs
,6.1.1.19,,,1464,269,,-,,Escherichia coli,BRENDA,citr__l,CHEBI:18211,argtrs
,6.1.1.19,C00077,,576,269,,-,L-Ornithine,Escherichia coli,BRENDA,orn,CHEBI:15729,argtrs
inhibition is fully reversible by the addition of zinc-complexing agents,6.1.1.20,C00038,,14,336,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,phetrs
"inhibition of tRNAPhe aminoacylation, required for conversion of ATP into diadenosine 5',5'''-P1,P4-tetraphosphate",6.1.1.20,C00038,,14,337,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,phetrs
weak,6.1.1.21,C00013,,17,369,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,histrs
,6.1.1.21,C00860,,2488,369,,-,L-Histidinol,Escherichia coli,BRENDA,histd,CHEBI:16255,histrs
"inhibition at 15 mM, optimal activation at 5-10 mM",6.1.1.21,C00305,,6,369,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,histrs
,6.2.1.5,C00026,,34,799,,-,2-Oxoglutarate,Escherichia coli,BRENDA,akg,CHEBI:30915,sucoas
adenosine 5´-tetraphosphate formation,6.2.1.5,C00008,,13,823,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,sucoas
,6.2.1.5,C00002,,4,799,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,sucoas
,6.2.1.5,C00004,,8,799,,-,NADH,Escherichia coli,BRENDA,nadh,CHEBI:16908,sucoas
presence of succinate plus CoA inhibits adenosine 5'-tetraphosphate formation,6.2.1.5,C00042,,58,823,,-,Succinate,Escherichia coli,BRENDA,succ,CHEBI:15741,sucoas
,6.2.1.26,C14818,,25,648945,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,sucbzl
,6.2.1.26,C00703,,33,648945,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,sucbzl
above 1 mM,6.2.1.26,C00305,,6,648945,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,sucbzl
,6.3.1.1,C00049,,294,858,,-,L-Aspartate,Escherichia coli,BRENDA,asp__l,CHEBI:17053,asns2
,6.3.1.2,C00020,,30,37497,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,glns
"no feedback inhibition of unadenylated enzyme form, enhanced sensitivity to feedback inhibition by adenylated enzyme form",6.3.1.2,C00020,,30,661216,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,glns
,6.3.1.2,,,60,37497,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,glns
"no feedback inhibition of unadenylated enzyme form, enhanced sensitivity to feedback inhibition by adenylated enzyme form",6.3.1.2,,,60,661216,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,glns
,6.3.1.2,C00352,,2841,37497,,-,D-Glucosamine 6-phosphate,Escherichia coli,BRENDA,gam6p,CHEBI:47987,glns
,6.3.1.2,,,163,37497,,-,,Escherichia coli,BRENDA,gly,CHEBI:57305,glns
"no feedback inhibition of unadenylated enzyme form, enhanced sensitivity to feedback inhibition by adenylated enzyme form",6.3.1.2,,,1062,661216,,-,,Escherichia coli,BRENDA,his__l,CHEBI:57595,glns
,6.3.1.2,C02989,,4830,694057,,-,L-Methionine S-oxide,Escherichia coli,BRENDA,metsox_s__l,CHEBI:17016,glns
,6.3.1.2,,,870,37497,,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,glns
,6.3.1.2,,,817,37497,,-,,Escherichia coli,BRENDA,trp__l,CHEBI:57912,glns
"no feedback inhibition of unadenylated enzyme form, enhanced sensitivity to feedback inhibition by adenylated enzyme form",6.3.1.2,,,817,661216,,-,,Escherichia coli,BRENDA,trp__l,CHEBI:57912,glns
,6.3.1.5,C00212,,122,953,,-,Adenosine,Escherichia coli,BRENDA,adn,CHEBI:16335,nads1
slightly inhibiting above 5 mM,6.3.1.5,C00305,,6,653053,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,nads1
"can satisfy the metal ion requirement at low concentrations, at high concentrations Mn2+ markedly inhibits",6.3.1.5,,,11,953,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,nads1
slight,6.3.2.1,,,15467,978,,-,,Escherichia coli,BRENDA,23dappa,CHEBI:58468,pants
slight,6.3.2.1,C01013,,4480,978,,-,3-Hydroxypropanoate,Escherichia coli,BRENDA,3hpp,CHEBI:33404,pants
27% inhibition at 1 mM,6.3.2.1,,,597,977,,-,,Escherichia coli,BRENDA,4abut,CHEBI:59888,pants
,6.3.2.1,,,597,"978, 979",,-,,Escherichia coli,BRENDA,4abut,CHEBI:59888,pants
,6.3.2.1,,,75,"977, 978, 979",,-,,Escherichia coli,BRENDA,ag,CHEBI:49468,pants
,6.3.2.1,C00020,,30,979,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,pants
uncompetitive,6.3.2.1,C00049,,304,979,,-,L-Aspartate,Escherichia coli,BRENDA,asp__l,CHEBI:17053,pants
24% inhibition at 1 mM,6.3.2.1,C00049,,724,977,,-,L-Aspartate,Escherichia coli,BRENDA,asp__l,CHEBI:17053,pants
,6.3.2.1,C00076,,15,"977, 978, 979",,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,pants
,6.3.2.1,C00175,,23,"977, 978",,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,pants
,6.3.2.1,,,19,"977, 978, 979",,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,pants
weak,6.3.2.1,,,153,979,,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,pants
,6.3.2.1,C00013,,17,979,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,pants
slight,6.3.2.1,C14818,,25,977,,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,pants
,6.3.2.1,C14818,,25,"978, 979",,-,Fe2+,Escherichia coli,BRENDA,fe2,CHEBI:29033,pants
32% inhibition at 1 mM,6.3.2.1,C00257,,4525,"977, 978",,-,D-Gluconic acid,Escherichia coli,BRENDA,glcn,CHEBI:33198,pants
30% inhibition at 1 mM,6.3.2.1,C00160,,479,"977, 978",,-,Glycolate,Escherichia coli,BRENDA,glyclt,CHEBI:17497,pants
,6.3.2.1,C00703,,33,"977, 978, 979",,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,pants
,6.3.2.1,,,251,"978, 979",,-,,Escherichia coli,BRENDA,ala__l,CHEBI:57972,pants
,6.3.2.1,,,835,978,,-,,Escherichia coli,BRENDA,val__l,CHEBI:57762,pants
uncompetitive,6.3.2.1,,,835,979,,-,,Escherichia coli,BRENDA,val__l,CHEBI:57762,pants
inhibition above 10 mM,6.3.2.1,C00305,,6,977,,-,Magnesium cation,Escherichia coli,BRENDA,mg2,CHEBI:18420,pants
inhibition above 5 mM,6.3.2.1,,,11,977,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,pants
slight,6.3.2.1,,,38,"977, 978",,-,,Escherichia coli,BRENDA,ni2,CHEBI:49786,pants
,6.3.2.1,,,38,979,,-,,Escherichia coli,BRENDA,ni2,CHEBI:49786,pants
,6.3.2.1,C00864,,3661,979,,-,Pantothenate,Escherichia coli,BRENDA,pnto__r,CHEBI:46905,pants
52% inhibition at 1 mM,6.3.2.1,,,595,977,,-,,Escherichia coli,BRENDA,taur,CHEBI:507393,pants
,6.3.2.1,,,595,"978, 979",,-,,Escherichia coli,BRENDA,taur,CHEBI:507393,pants
,6.3.2.1,C00038,,14,"977, 978, 979",,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,pants
,6.3.2.2,C00703,,33,1120,,-,Mercury(2+),Escherichia coli,BRENDA,hg2,CHEBI:16793,glucys
,6.3.2.4,C00463,,49126,727157,,-,Indole,Escherichia coli,BRENDA,indole,CHEBI:16881,alaalar
,6.3.2.4,,,1348,"1235, 1236",,-,,Escherichia coli,BRENDA,alaala,CHEBI:57822,alaalar
,6.3.2.4,,,163,1235,,-,,Escherichia coli,BRENDA,gly,CHEBI:57305,alaalar
competitive with respect to 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole,6.3.2.6,C00130,,232,661204,,-,IMP,Escherichia coli,BRENDA,imp,CHEBI:17202,prascsi
,6.3.2.8,C00008,,13,662701,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,uamas
,6.3.2.8,,,163,"1286, 1289",,-,,Escherichia coli,BRENDA,gly,CHEBI:57305,uamas
weak,6.3.2.8,,,336,"1286, 1288",,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,uamas
,6.3.2.8,C00186,,403,1286,,-,(S)-Lactate,Escherichia coli,BRENDA,lac__l,CHEBI:422,uamas
,6.3.2.8,,,262,"1286, 1289",,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,uamas
,6.3.2.8,C01212,,4287,1289,,-,UDP-N-acetylmuramoyl-L-alanine,Escherichia coli,BRENDA,uama,CHEBI:84726,uamas
,6.3.2.9,C00025,,202,1293,,-,L-Glutamate,Escherichia coli,BRENDA,glu__l,CHEBI:16015,uamags
,6.3.2.9,C00692,,3850,"1276, 1293",,-,UDP-N-acetylmuramoyl-L-alanyl-D-glutamate,Escherichia coli,BRENDA,uamag,CHEBI:16970,uamags
inhibition of wild-type enzyme,6.3.2.10,C00033,,47,651110,,-,Acetate,Escherichia coli,BRENDA,ac,CHEBI:15366,ugmdds
slight inhibition of wild-type enzyme,6.3.2.10,C00246,,462,651110,,-,Butanoic acid,Escherichia coli,BRENDA,but,CHEBI:30772,ugmdds
inhibition of wild-type enzyme,6.3.2.10,C00058,,120,651110,,-,Formate,Escherichia coli,BRENDA,for,CHEBI:30751,ugmdds
inhibition of wild-type enzyme,6.3.2.10,C00163,,312,651110,,-,Propanoate,Escherichia coli,BRENDA,ppa,CHEBI:30768,ugmdds
"500 mM, 44% inhibition",6.3.2.13,C00246,,462,651110,,-,Butanoic acid,Escherichia coli,BRENDA,but,CHEBI:30772,uaagds
treatment of cells with trimethoprim leads to inhibition due to accumulation of dihydrofolate through the inhibition of dihydrofolate reductase. Therefore falling dihydrofolate reductase activity leads to falling folylpolyglutamate synthase activity in a domino-like cascade,6.3.2.17,C00415,,1351,694310,,-,Dihydrofolate,Escherichia coli,BRENDA,dhf,CHEBI:15633,dhfs
5% inhibition of ATP binding at 0.1 mM,6.3.2.17,C00921,,12509,649464,,-,Dihydropteroate,Escherichia coli,BRENDA,dhpt,CHEBI:4581,dhfs
,6.3.3.1,C00008,,13,1308,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,prais
,6.3.3.1,C00009,,16,1308,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,prais
,6.3.3.3,C00147,,144,653958,,-,Adenine,Escherichia coli,BRENDA,ade,CHEBI:16708,dbts
competitive to ATP,6.3.3.3,C00008,,13,1334,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,dbts
,6.3.3.3,C00008,,13,1338,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,dbts
,6.3.3.3,C00020,,30,1338,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,dbts
"10 mM, 30% inhibition",6.3.3.3,,,2553,1334,,-,,Escherichia coli,BRENDA,dtbt,CHEBI:42280,dbts
"no guanosine, kact: 1.5/sec, KA: 0.21 mM, Ki: 0.36 mM; the GTP analogue is capable of inhibiting Gln-dependent CTP formation at over 0.15 mM",6.3.4.2,C00286,,5697,674909,,-,dGTP,Escherichia coli,BRENDA,dgtp,CHEBI:16497,ctps2
,6.3.4.2,C00330,,36605,674909,,-,Deoxyguanosine,Escherichia coli,BRENDA,dgsn,CHEBI:17172,ctps2
,6.3.4.2,C00147,,144,702613,,-,Adenine,Escherichia coli,BRENDA,ade,CHEBI:16708,ctps2
,6.3.4.2,C00212,,122,674909,,-,Adenosine,Escherichia coli,BRENDA,adn,CHEBI:16335,ctps2
above 2 mM,6.3.4.2,C00175,,23,649002,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,ctps2
,6.3.4.2,,,60,648986,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,ctps2
IC50: 0.15 mM,6.3.4.2,,,60,649000,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,ctps2
"inhibition is not reversed by EDTA, in presence of dithiothreitol inhibition at concentrations below 0.2 mM",6.3.4.2,,,19,649002,,-,,Escherichia coli,BRENDA,cu2,CHEBI:29036,ctps2
weak,6.3.4.2,C04322,,3810,648963,,-,Delta1-Pyrroline-5-carboxylate,Escherichia coli,BRENDA,1pyr5c,CHEBI:1372,ctps2
,6.3.4.2,C00035,,53,674909,,-,GDP,Escherichia coli,BRENDA,gdp,CHEBI:17552,ctps2
,6.3.4.2,C00144,,162,674909,,-,GMP,Escherichia coli,BRENDA,gmp,CHEBI:17345,ctps2
"inhibition of glutamine-dependent CTP formation above 0.15 mM, inhibition of glutamine-dependent CTP formation in a concentration-dependent manner",6.3.4.2,C00044,,37,661241,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,ctps2
"0.1 mM guanosine, kact: 10.3/sec, KA: 0.088 mM, Ki: 0.22 mM; 0.2 mM guanosine, kact: 8.2/sec, KA: 0.078 mM, Ki: 0.12 mM; allosteric effector, structural requirements for activation are stringent, but requirements for inhibition are lax. GTP promotes Gln hydrolysis but inhibits Gln-dependent CTP formation at concentrations of over 0.15 mM; no guanosine, kact: 10.6/sec, KA: 0.081 mM, Ki: 0.28 mM",6.3.4.2,C00044,,37,674909,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,ctps2
"GTP acts a positive allosteric effector for Gln-dependent CTP formation. However, at concentrations exceeding 0.15 mM, GTP inhibits Gln-dependent CTP formation. Moreover, GTP is an inhibitor of NH3-dependent CTP formation at all concentrations",6.3.4.2,C00044,,37,702613,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,ctps2
,6.3.4.2,C00387,,296,674909,,-,Guanosine,Escherichia coli,BRENDA,gsn,CHEBI:16750,ctps2
,6.3.4.2,C00294,,167,674909,,-,Inosine,Escherichia coli,BRENDA,ins,CHEBI:17596,ctps2
"no guanosine, kact: 5.2/sec, KA: 2.9 mM, Ki: 4.5 mM; the GTP analogue is capable of inhibiting Gln-dependent CTP formation at over 0.15 mM",6.3.4.2,C00081,,229,674909,,-,ITP,Escherichia coli,BRENDA,itp,CHEBI:16039,ctps2
above 2 mM,6.3.4.2,,,11,649002,,-,,Escherichia coli,BRENDA,mn2,CHEBI:29035,ctps2
in presence of dithiothreitol inhibition at concentrations below 0.2 mM,6.3.4.2,,,38,649002,,-,,Escherichia coli,BRENDA,ni2,CHEBI:49786,ctps2
,6.3.4.2,C00059,,245,648963,,-,Sulfate,Escherichia coli,BRENDA,so4,CHEBI:26836,ctps2
,6.3.4.2,C00106,,334,702613,,-,Uracil,Escherichia coli,BRENDA,ura,CHEBI:17568,ctps2
"pH-dependent inhibition, overview",6.3.4.2,,,1421,702613,,-,,Escherichia coli,BRENDA,urate,CHEBI:62589,ctps2
,6.3.4.2,C00299,,261,702613,,-,Uridine,Escherichia coli,BRENDA,uri,CHEBI:16704,ctps2
"; pH-dependent inhibition, overview",6.3.4.2,C00385,,234,702613,,-,Xanthine,Escherichia coli,BRENDA,xan,CHEBI:48517,ctps2
,6.3.4.2,C01762,,1222,674909,,-,Xanthosine,Escherichia coli,BRENDA,xtsn,CHEBI:18107,ctps2
"inhibition is reversed by EDTA, in presence of dithiothreitol inhibition at concentrations below 0.2 mM",6.3.4.2,C00038,,14,649002,,-,Zinc cation,Escherichia coli,BRENDA,zn2,CHEBI:29105,ctps2
,6.3.4.4,C00122,,170,652356,,-,Fumarate,Escherichia coli,BRENDA,fum,CHEBI:18012,adss
,6.3.4.4,C00035,,53,"1537, 1557",,-,GDP,Escherichia coli,BRENDA,gdp,CHEBI:17552,adss
,6.3.4.4,C00035,,44201,651925,,-,GDP,Escherichia coli,BRENDA,gdp,CHEBI:17552,adss
competitive with respect to GTP and noncompetitive with respect to L-Asp and IMP,6.3.4.4,C01228,,44202,1542,,-,"Guanosine 3',5'-bis(diphosphate)",Escherichia coli,BRENDA,ppgpp,CHEBI:17633,adss
,6.3.4.4,C00130,,232,1557,,-,IMP,Escherichia coli,BRENDA,imp,CHEBI:17202,adss
,6.3.4.4,,,673,1557,,-,,Escherichia coli,BRENDA,no3,CHEBI:17632,adss
poor inhibitor,6.3.4.4,C00042,,58,649423,,-,Succinate,Escherichia coli,BRENDA,succ,CHEBI:15741,adss
,6.3.4.4,C00042,,58,"1537, 652356",,-,Succinate,Escherichia coli,BRENDA,succ,CHEBI:15741,adss
,6.3.4.18,C00255,,351,702643,,-,Riboflavin,Escherichia coli,BRENDA,ribflv,CHEBI:17015,airc2
,6.3.5.2,C00559,,357,1362,,-,Deoxyadenosine,Escherichia coli,BRENDA,dad_2,CHEBI:17256,gmps2
,6.3.5.2,,,12413,1362,,-,,Escherichia coli,BRENDA,adn,CHEBI:45327,gmps2
,6.3.5.2,C00212,,122,1362,,-,Adenosine,Escherichia coli,BRENDA,adn,CHEBI:16335,gmps2
,6.3.5.2,C00008,,13,1362,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,gmps2
competitive with respect to ATP; kinetic parameters for the two progressively formed inhibitory complexes,6.3.5.2,C00013,,17,1362,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,gmps2
"0.33 mM, 50% inhibition",6.3.5.2,C00144,,162,649891,,-,GMP,Escherichia coli,BRENDA,gmp,CHEBI:17345,gmps2
substrate inhibition above 0.2 mM,6.3.5.2,C00655,,1007,727023,,-,Xanthosine 5'-phosphate,Escherichia coli,BRENDA,xmp,CHEBI:15652,gmps2
,6.3.5.3,C00025,,343,1670,,-,L-Glutamate,Escherichia coli,BRENDA,glu__l,CHEBI:16015,prfgs
noncompetitive vs. ATP and aspartate,6.3.5.4,,,2264,649836,,-,,Escherichia coli,BRENDA,asn__l,CHEBI:58048,asns1
,6.3.5.4,C00049,,96164,1692,,-,L-Aspartate,Escherichia coli,BRENDA,asp__l,CHEBI:17053,asns1
noncompetitive vs. ATP,6.3.5.4,C00013,,17,649836,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,asns1
"0.2 mM, inhibits Gln-dependent activity. No effect on the activity with NH4+ in carbamoyl-phosphate synthase reaction",6.3.5.5,,,22,"1725, 1731",,-,,Escherichia coli,BRENDA,h2o2,CHEBI:29192,cbps
slight inhibition at 25°C,6.3.5.5,C00130,,232,649877,,-,IMP,Escherichia coli,BRENDA,imp,CHEBI:17202,cbps
"binds with good affinity to the enzyme, small effect below 35°C",6.3.5.5,C00130,,232,650927,,-,IMP,Escherichia coli,BRENDA,imp,CHEBI:17202,cbps
inhibits two partial reactions catalyzed by the enzyme: bicarbonate-dependent ATPase and ATP synthesis from carbamoyl phosphate,6.3.5.5,C04058,,94642,1738,,-,Bis(5'-adenosyl) pentaphosphate,Escherichia coli,BRENDA,ap5a,CHEBI:28898,cbps
inhibits to a lesser extent than UMP,6.3.5.5,C00015,,26,1731,,-,UDP,Escherichia coli,BRENDA,udp,CHEBI:17659,cbps
allosteric inhibition,6.3.5.5,C00105,,133,1729,,-,UMP,Escherichia coli,BRENDA,ump,CHEBI:16695,cbps
phosphate increases inhibition,6.3.5.5,C00105,,133,1731,,-,UMP,Escherichia coli,BRENDA,ump,CHEBI:16695,cbps
inhibition is not reversed by glycerol,6.3.5.5,C00105,,133,1746,,-,UMP,Escherichia coli,BRENDA,ump,CHEBI:16695,cbps
feedback inhibition,6.3.5.5,C00105,,133,1751,,-,UMP,Escherichia coli,BRENDA,ump,CHEBI:16695,cbps
strong effect on ATP synthesis reaction,6.3.5.5,C00105,,133,649877,,-,UMP,Escherichia coli,BRENDA,ump,CHEBI:16695,cbps
Lys993 is cross-linked with UMP,6.3.5.5,C00105,,133,649895,,-,UMP,Escherichia coli,BRENDA,ump,CHEBI:16695,cbps
"the inhibitor stabilizes the (alpha,beta)2-dimer of enzyme",6.3.5.5,C00105,,133,650020,,-,UMP,Escherichia coli,BRENDA,ump,CHEBI:16695,cbps
not chimeric protein,6.3.5.5,C00105,,133,651901,,-,UMP,Escherichia coli,BRENDA,ump,CHEBI:16695,cbps
effect on chimeric enzyme and Escherichia coli enzyme,6.3.5.5,C00105,,133,652334,,-,UMP,Escherichia coli,BRENDA,ump,CHEBI:16695,cbps
,6.3.5.5,C00105,,133,"1725, 649457, 649886, 650798, 650927, 651292, 651471, 651882, 651937, 652351, 652788",,-,UMP,Escherichia coli,BRENDA,ump,CHEBI:16695,cbps
the IMP activator and the UMP inhibitor bind to the same site on the enzyme,6.3.5.5,C00105,,133,652823,,-,UMP,Escherichia coli,BRENDA,ump,CHEBI:16695,cbps
"product of the pyrimidine nucleotide pathway, acts as a negative allosteric effector for eCPS, which also catalyzes the first step of this pathway",6.3.5.5,C00105,,133,693247,,-,UMP,Escherichia coli,BRENDA,ump,CHEBI:16695,cbps
,6.3.5.5,,,116,1741,,-,,Escherichia coli,BRENDA,urea,CHEBI:32285,cbps
inhibits to a lesser extent than UMP,6.3.5.5,C00075,,65,1731,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,cbps
,6.3.5.5,C00075,,65,1751,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,cbps
inhibits activity of Escherichia coli and chimeric enzyme,6.3.5.5,C00075,,65,651901,,-,UTP,Escherichia coli,BRENDA,utp,CHEBI:15713,cbps
pH 7.1,1.1.1.42,C00074,0.31,51,680481,,-,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,icdhyr
"pH 8.0, temperature not specified in the publication, varied substrate: NADP+",1.1.1.49,C00005,0.01,5,722577,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,g6pdh2r
"25°C, pH 8.0, competitive inhibition constant",1.1.1.49,C00005,0.038,5,722244,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,g6pdh2r
"pH 8.0, temperature not specified in the publication, varied substrate: glucose 6-phosphate, slope inhibition constant",1.1.1.49,C00005,0.04,5,722577,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,g6pdh2r
"pH 8.0, temperature not specified in the publication, varied substrate: glucose 6-phosphate, intercept inhibition constant",1.1.1.49,C00005,0.18,5,722577,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,g6pdh2r
"25°C, pH 8.0, non-competitive inhibition constant",1.1.1.49,C00005,2.09,5,722244,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,g6pdh2r
"pH 8.0, 22°C, wild-type enzyme",1.1.1.86,C00005,0.0012,5,639183,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,kara1
"pH 7.4, 23°C, wild-type enzyme",1.1.1.94,,0.0044,4869,669175,,-,,Escherichia coli,BRENDA,glyc3p,CHEBI:57597,g3pd2
"pH 7.4, 23°C, wild-type enzyme",1.1.1.94,C13050,0.1,402,669177,,-,Cyclic ADP-ribose,Escherichia coli,BRENDA,adprib,CHEBI:31445,g3pd2
"pH 7.4, 23°C, wild-type enzyme",1.1.1.94,C00003,0.2,7,669177,,-,NAD+,Escherichia coli,BRENDA,nad,CHEBI:15846,g3pd2
"pH 7.4, 23°C, wild-type enzyme",1.1.1.94,C00006,0.25,10,669177,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,g3pd2
"pH 7.4, 23°C, wild-type enzyme",1.1.1.94,C00008,0.8,13,669177,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,g3pd2
"pH 7.4, 23°C, wild-type enzyme",1.1.1.94,C00020,5.0,30,669177,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,g3pd2
pH 7.6,1.1.1.169,C00002,0.61,4,669806,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,dpr
pH 7.6,1.1.1.169,C00008,1.05,13,669806,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,dpr
pH 7.6,1.1.1.169,C00020,6.3,30,669806,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,dpr
pH 7.6,1.1.1.169,C00009,27.0,16,669806,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,dpr
,1.1.1.205,C00144,0.092,162,347941,,-,GMP,Escherichia coli,BRENDA,gmp,CHEBI:17345,impd
,1.1.1.271,C00035,0.061,53,389515,,-,GDP,Escherichia coli,BRENDA,gdp,CHEBI:17552,gdmane
,1.1.1.271,C00006,0.069,10,389515,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,gdmane
"pH 7.5, 24°C",1.1.99.33,C00058,7.1,120,698687,,-,Formate,Escherichia coli,BRENDA,for,CHEBI:30751,fhl
,1.2.1.8,C00601,0.53,769,390329,,-,Phenylacetaldehyde,Escherichia coli,BRENDA,pacald,CHEBI:16424,betaldhx
,1.2.1.8,C00084,5.7,90,390329,,-,Acetaldehyde,Escherichia coli,BRENDA,acald,CHEBI:15343,betaldhx
,1.2.1.8,,11.0,149,390329,,-,,Escherichia coli,BRENDA,chol,CHEBI:72322,betaldhx
,1.2.1.8,C00189,78.0,456,390329,,-,Ethanolamine,Escherichia coli,BRENDA,etha,CHEBI:16000,betaldhx
,1.2.1.8,,130.0,2750,390329,,-,,Escherichia coli,BRENDA,sarcs,CHEBI:57433,betaldhx
"at 25°C in 50 mM Tris/HCl buffer, pH 8.0",1.2.1.10,C00084,265.0,90,724721,,-,Acetaldehyde,Escherichia coli,BRENDA,acald,CHEBI:15343,acald
,1.2.1.11,,26.0,1989,390200,,-,,Escherichia coli,BRENDA,tungs,CHEBI:36272,asad
isozyme B,1.2.1.21,C00160,0.00085,479,390213,,-,Glycolate,Escherichia coli,BRENDA,glyclt,CHEBI:17497,gcaldd
isozyme A,1.2.1.21,C00266,0.0021,604,390213,,-,Glycolaldehyde,Escherichia coli,BRENDA,gcald,CHEBI:17071,gcaldd
isozyme B,1.2.1.21,C00266,0.004,604,390213,,-,Glycolaldehyde,Escherichia coli,BRENDA,gcald,CHEBI:17071,gcaldd
isozyme A,1.2.1.21,C00160,0.085,479,390213,,-,Glycolate,Escherichia coli,BRENDA,glyclt,CHEBI:17497,gcaldd
isozyme C,1.2.1.21,C00160,0.13,479,390213,,-,Glycolate,Escherichia coli,BRENDA,glyclt,CHEBI:17497,gcaldd
inhibition of isozyme C,1.2.1.21,C00314,0.33,1051,390214,,-,Pyridoxine,Escherichia coli,BRENDA,pydxn,CHEBI:16709,gcaldd
isozyme C,1.2.1.21,C00266,8.3,604,390213,,-,Glycolaldehyde,Escherichia coli,BRENDA,gcald,CHEBI:17071,gcaldd
,1.2.1.41,C00005,0.002,5,390307,,-,NADPH,Escherichia coli,BRENDA,nadph,CHEBI:16474,g5sd
assay with whole enzyme complex,1.2.4.1,C00048,0.5,3343,348956,,-,Glyoxylate,Escherichia coli,BRENDA,glx,CHEBI:16891,pdh
assay with whole enzyme complex,1.2.4.1,C00168,1.0,5529,348956,,-,Hydroxypyruvate,Escherichia coli,BRENDA,hpyr,CHEBI:30841,pdh
assay with whole enzyme complex,1.2.4.1,C00109,2.25,29733,348956,,-,2-Oxobutanoate,Escherichia coli,BRENDA,2obut,CHEBI:30831,pdh
,1.3.1.9,C00463,0.00015,472,696692,,-,Indole,Escherichia coli,BRENDA,indole,CHEBI:16881,ear121x
,1.3.1.9,,0.02,128,390503,,-,,Escherichia coli,BRENDA,pmtcoa,CHEBI:57379,ear121x
,1.4.3.5,C00018,0.008,32,"391903, 391904, 654870",,-,Pyridoxal phosphate,Escherichia coli,BRENDA,pydx5p,CHEBI:18405,pdx5poi
pH and temperature not specified in the publication,1.4.3.5,C00018,0.008,32,724427,,-,Pyridoxal phosphate,Escherichia coli,BRENDA,pydx5p,CHEBI:18405,pdx5poi
substrate inhibition,1.4.3.5,C00627,0.05,1037,654870,,-,Pyridoxine phosphate,Escherichia coli,BRENDA,pdx5p,CHEBI:28803,pdx5poi
"recombinant wild-type enzyme, pH 7.2, 4°C",1.5.1.20,,0.061,934,654771,,-,,Escherichia coli,BRENDA,mlthf,CHEBI:20502,mthfr2
"wild-type, pH 7.2, 25°C",1.5.1.20,C00143,0.32,401,696353,,-,"5,10-Methylenetetrahydrofolate",Escherichia coli,BRENDA,mlthf,CHEBI:1989,mthfr2
"at pH 10.5, reduced enzyme",1.7.99.4,C01326,0.044,118,395167,,-,Hydrogen cyanide,Escherichia coli,BRENDA,cyan,CHEBI:18407,no3r2bpp
,1.8.1.2,C01326,0.006,118,392968,,-,Hydrogen cyanide,Escherichia coli,BRENDA,cyan,CHEBI:18407,sulri
,1.8.1.2,C06697,0.08,397,392968,,-,Arsenite,Escherichia coli,BRENDA,aso3,CHEBI:49900,sulri
at 25°C,1.8.1.9,C00006,0.015,10,393993,,-,NADP+,Escherichia coli,BRENDA,nadp,CHEBI:18009,trdr
competitive vs. CDP,1.17.4.1,C00035,0.007,53,437939,,-,GDP,Escherichia coli,BRENDA,gdp,CHEBI:17552,rndr1
competitive vs. CDP,1.17.4.1,C00015,0.5,26,437939,,-,UDP,Escherichia coli,BRENDA,udp,CHEBI:17659,rndr1
,2.1.1.79,,0.22,843,"485626, 485631",,-,,Escherichia coli,BRENDA,ahcys,CHEBI:57856,cfas160e
,2.1.3.2,,0.037,60,485837,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,aspct
,2.1.3.2,C00013,0.051,17,485843,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,aspct
,2.1.3.2,C00013,0.09,17,485837,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,aspct
"inhibition of catalytic subunits, C3",2.1.3.2,C01327,1.1,298,485853,,-,Hydrochloric acid,Escherichia coli,BRENDA,cl,CHEBI:17883,aspct
"inhibition of catalytic subunits, C3",2.1.3.2,C00042,3.5,58,485853,,-,Succinate,Escherichia coli,BRENDA,succ,CHEBI:15741,aspct
"inhibition of catalytic subunits, C3",2.1.3.2,C00122,5.3,170,485853,,-,Fumarate,Escherichia coli,BRENDA,fum,CHEBI:18012,aspct
"substrate inhibition, complex of catalytic and regulatory subunits, C3R6",2.1.3.2,C00049,7.9,97,485841,,-,L-Aspartate,Escherichia coli,BRENDA,asp__l,CHEBI:17053,aspct
"substrate inhibition, complex of catalytic subunits, C3",2.1.3.2,C00049,80.0,724,485841,,-,L-Aspartate,Escherichia coli,BRENDA,asp__l,CHEBI:17053,aspct
,2.1.3.3,,5.5,127,485898,,-,,Escherichia coli,BRENDA,leu__l,CHEBI:57427,ocbt
,2.1.3.3,,13.0,103,485898,,-,,Escherichia coli,BRENDA,ala__l,CHEBI:57972,ocbt
,2.1.3.3,,13.5,246,485898,,-,,Escherichia coli,BRENDA,val__l,CHEBI:57762,ocbt
,2.1.3.3,,14.0,311,485898,,-,,Escherichia coli,BRENDA,ile__l,CHEBI:58045,ocbt
,2.1.3.3,,15.0,72,485898,,-,,Escherichia coli,BRENDA,gly,CHEBI:57305,ocbt
,2.1.3.3,C00073,40.0,88,485898,,-,L-Methionine,Escherichia coli,BRENDA,met__l,CHEBI:16643,ocbt
,2.1.3.3,,63.5,95,485898,,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,ocbt
,2.1.3.3,,110.0,266,485898,,-,,Escherichia coli,BRENDA,asn__l,CHEBI:58048,ocbt
"pH 8.0, 37°C",2.2.1.7,C00577,3.2,639,719975,,-,D-Glyceraldehyde,Escherichia coli,BRENDA,glyald,CHEBI:17378,dxps
"25°C, pH 7.5, wild-type enzyme",2.3.1.30,,0.0006,336,676935,,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,serat
wild-type protein,2.3.3.9,C00209,0.023,185,706621,,-,Oxalate,Escherichia coli,BRENDA,oxa,CHEBI:16995,mals
wild-type protein,2.3.3.9,C00209,0.037,185,706621,,-,Oxalate,Escherichia coli,BRENDA,oxa,CHEBI:16995,mals
wild-type protein,2.3.3.9,C00022,0.65,31,706621,,-,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,mals
wild-type enzyme,2.3.3.16,C00004,0.0028,8,659254,,-,NADH,Escherichia coli,BRENDA,nadh,CHEBI:16908,cs
"wild-type enzyme, in presence of 0.1 M KCl",2.3.3.16,C00036,0.026,57,659254,,-,Oxaloacetate,Escherichia coli,BRENDA,oaa,CHEBI:30744,cs
wild-type,2.3.3.16,C00026,0.76,34,488060,,-,2-Oxoglutarate,Escherichia coli,BRENDA,akg,CHEBI:30915,cs
,2.4.1.1,C01478,0.5,255,488294,,-,Arsenic acid,Escherichia coli,BRENDA,aso4,CHEBI:18231,glcp2
,2.4.1.1,C00498,0.7,598,488238,,-,ADP-glucose,Escherichia coli,BRENDA,adpglc,CHEBI:15751,glcp2
,2.4.1.1,C00842,1.0,1766,488238,,-,dTDP-glucose,Escherichia coli,BRENDA,dtdpglu,CHEBI:15700,glcp2
,2.4.1.1,C00029,2.0,64,488238,,-,UDP-glucose,Escherichia coli,BRENDA,udpg,CHEBI:46229,glcp2
,2.4.1.1,C00031,2.5,223,488238,,-,D-Glucose,Escherichia coli,BRENDA,glc__d,CHEBI:4167,glcp2
"in 50 mM potassium phosphate buffer, pH 6.5, 25°C",2.4.2.4,C00299,0.06,261,672287,,-,Uridine,Escherichia coli,BRENDA,uri,CHEBI:16704,duripp
,2.4.2.14,C00020,0.36,30,489747,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,gluprt
"pH 7.0, 24°C",2.5.1.54,,0.02,618,639746,,-,,Escherichia coli,BRENDA,tyr__l,CHEBI:58315,ddpa
,2.6.1.16,C04322,0.023,51635,639926,,-,Delta1-Pyrroline-5-carboxylate,Escherichia coli,BRENDA,1pyr5c,CHEBI:1372,gf6pta
wild type enzyme,2.6.1.16,C00352,0.56,93494,672444,,-,D-Glucosamine 6-phosphate,Escherichia coli,BRENDA,gam6p,CHEBI:47987,gf6pta
pH 7.2,2.6.1.16,C01096,2.46,22020,639929,,-,Sorbitol 6-phosphate,Escherichia coli,BRENDA,sbt6p,CHEBI:17044,gf6pta
"wild-type, pH 7.8, 25°C",2.6.1.19,C00042,27.0,58,661189,,-,Succinate,Escherichia coli,BRENDA,succ,CHEBI:15741,abta
"pH 8.5, 37°C",2.6.1.62,,0.025,8030,"637092, 637094",,-,,Escherichia coli,BRENDA,8aonn,CHEBI:57532,amaotr
native enzyme,2.6.1.62,,0.025,1494,661047,,-,,Escherichia coli,BRENDA,8aonn,CHEBI:57532,amaotr
"pH 8.0, 25°C",2.7.1.25,C00224,0.0004,425,641215,,-,Adenylyl sulfate,Escherichia coli,BRENDA,aps,CHEBI:17709,adsk
in 20% DMSO,2.7.1.39,,0.1,345,641473,,-,,Escherichia coli,BRENDA,hom__l,CHEBI:57476,hsk
wild-type enzyme,2.7.1.39,C00025,0.2,1163,641471,,-,L-Glutamate,Escherichia coli,BRENDA,glu__l,CHEBI:16015,hsk
wild-type enzyme,2.7.1.39,,0.3,780,641471,,-,,Escherichia coli,BRENDA,thr__l,CHEBI:57926,hsk
wild-type enzyme,2.7.1.39,,0.46,336,641471,,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,hsk
"pH 7.8, 37°C",2.7.1.39,,0.6,780,641470,,-,,Escherichia coli,BRENDA,thr__l,CHEBI:57926,hsk
"pH 7.8, 37°C",2.7.1.39,,1.0,336,641470,,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,hsk
"pH 7.8, 27°C",2.7.1.39,,1.0,780,641465,,-,,Escherichia coli,BRENDA,thr__l,CHEBI:57926,hsk
pH 7.6,2.7.1.39,,2.0,345,641463,,-,,Escherichia coli,BRENDA,hom__l,CHEBI:57476,hsk
,2.7.1.39,C01005,2.7,1189,641471,,-,O-Phospho-L-serine,Escherichia coli,BRENDA,pser__l,CHEBI:15811,hsk
"aqueous sulution, pH 8",2.7.1.39,,3.0,345,641473,,-,,Escherichia coli,BRENDA,hom__l,CHEBI:57476,hsk
"pH 7.8, 37°C",2.7.1.39,,4.0,305,641470,,-,,Escherichia coli,BRENDA,hcys__l,CHEBI:58199,hsk
"pH 7.8, 37°C",2.7.1.39,,4.5,1074,641470,,-,,Escherichia coli,BRENDA,ile__l,CHEBI:58045,hsk
"pH 7.8, 37°C",2.7.1.39,,10.0,835,641470,,-,,Escherichia coli,BRENDA,val__l,CHEBI:57762,hsk
"pH 7.8, 37°C",2.7.1.39,,27.0,262,641470,,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,hsk
"pH 7.8, 37°C",2.7.1.39,,35.0,468,641470,,-,,Escherichia coli,BRENDA,met__l,CHEBI:57844,hsk
"pH 6.2, 37°C",2.7.1.49,C00314,0.0027,1051,641658,,-,Pyridoxine,Escherichia coli,BRENDA,pydxn,CHEBI:16709,hmpk1
"pH 6.2, 37°C",2.7.1.49,C01279,0.09,7509,641658,,-,4-Amino-5-hydroxymethyl-2-methylpyrimidine,Escherichia coli,BRENDA,4ahmmp,CHEBI:16892,hmpk1
"pH 7.6, 37°C",2.7.1.56,C00008,0.28,13,641683,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,fruk
"pH 7.6, 37°C",2.7.1.56,C00354,6.1,1895,641683,,-,"D-Fructose 1,6-bisphosphate",Escherichia coli,BRENDA,fdp,CHEBI:37736,fruk
"recombinant wild-type bifunctional holoenzyme, inhibition of asparate kinase activity",2.7.2.4,,0.33,250,654640,,-,,Escherichia coli,BRENDA,thr__l,CHEBI:57926,aspk
"pH 8.0, 25°C, aspartokinase III",2.7.2.4,,7.7,345,642329,,-,,Escherichia coli,BRENDA,hom__l,CHEBI:57476,aspk
"pH 8.0, 25°C, aspartokinase III",2.7.2.4,C00149,53.0,247,642329,,-,(S)-Malate,Escherichia coli,BRENDA,mal__l,CHEBI:30797,aspk
"pH 8.0, 25°C, aspartokinase III",2.7.2.4,C00025,128.0,41,642329,,-,L-Glutamate,Escherichia coli,BRENDA,glu__l,CHEBI:16015,aspk
"pH 8.0, 25°C, aspartokinase III",2.7.2.4,C00042,159.0,58,642329,,-,Succinate,Escherichia coli,BRENDA,succ,CHEBI:15741,aspk
"wild-type, pH 7.0, 25°C",2.7.2.8,C00002,30.4,4,659704,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,acgk
"pH 7.0, 37°C",2.7.2.11,C00008,0.06,13,642200,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,glu5k
"pH 8.0, 37ºC, D-ribose 5-phosphate 5 mM, Kis value",2.7.6.1,C00076,0.032,15,642737,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,prpps
"pH 8.0, 37ºC, D-ribose 5-phosphate 5 mM, Kii value",2.7.6.1,C00076,0.047,15,642737,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,prpps
"pH 8.0, 37ºC, D-ribose 5-phosphate 0.5 mM, Kis value",2.7.6.1,C00076,0.053,15,642737,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,prpps
"pH 8.0, 37ºC, D-ribose 5-phosphate 0.5 mM, Kii value",2.7.6.1,C00076,0.11,15,642737,,-,Calcium cation,Escherichia coli,BRENDA,ca2,CHEBI:29108,prpps
"pH 8.0, 37ºC, D-ribose 5-phosphate 0.5 mM, Kii value",2.7.6.1,C00008,0.334,13,642737,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,prpps
"Substrate: dephospho-CoA, Cosubstrate: diphosphate (1.6 mM)",2.7.7.3,C01134,0.0084,6013,674344,,-,Pantetheine 4'-phosphate,Escherichia coli,BRENDA,pan4p,CHEBI:4222,ptpati
"Substrate: dephospho-CoA, Cosubstrate: diphosphate (1.6 mM)",2.7.7.3,C00010,0.011,18,674344,,-,CoA,Escherichia coli,BRENDA,coa,CHEBI:15346,ptpati
"Substrate: phosphopantetheine, Cosubstrate: ATP (300 microM)",2.7.7.3,C00010,0.014,18,674344,,-,CoA,Escherichia coli,BRENDA,coa,CHEBI:15346,ptpati
"Substrate: ATP, Cosubstrate: phosphopantetheine (300 microM)",2.7.7.3,C00010,0.07,18,674344,,-,CoA,Escherichia coli,BRENDA,coa,CHEBI:15346,ptpati
"Substrate: Pyrophosphate, Cosubstrate: dephospho-CoA (300 microM)",2.7.7.3,C00010,0.117,18,674344,,-,CoA,Escherichia coli,BRENDA,coa,CHEBI:15346,ptpati
"Substrate: ATP, Cosubstrate: phosphopantetheine (300 microM)",2.7.7.3,C00013,0.12,17,674344,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,ptpati
"Substrate: phosphopantetheine, Cosubstrate: ATP (3.0 mM)",2.7.7.3,C00882,0.121,2018,674344,,-,Dephospho-CoA,Escherichia coli,BRENDA,dpcoa,CHEBI:15468,ptpati
"Substrate: diphosphate, Cosubstrate: dephospho-CoA (500 microM)",2.7.7.3,C01134,0.131,6013,674344,,-,Pantetheine 4'-phosphate,Escherichia coli,BRENDA,pan4p,CHEBI:4222,ptpati
"Substrate: ATP, Cosubstrate: phosphopantetheine (300 microM)",2.7.7.3,C00882,0.192,2018,674344,,-,Dephospho-CoA,Escherichia coli,BRENDA,dpcoa,CHEBI:15468,ptpati
"pH 8.0, 37°C, wild-type enzyme in presence of 0.1 mM fructose-1,6-bisphosphate",2.7.7.27,C00020,0.007,30,643152,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,glgc
"pH 7.6, 37°C, wild-type enzyme",2.7.7.27,C00020,0.04,30,643148,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,glgc
"pH 7.0, 37°C, wild-type enzyme, in the presence of a saturating concentration of fructose 1,6-bisphosphate",2.7.7.27,C00020,0.094,30,643148,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,glgc
"pH 8.0, 37°C, the chimeric enzymes, AE contains the N-terminus of Agrobacterium tumefaciens enzyme and the C-terminus of Escherichia coli enzyme is slightly activated by AMP in the range of 0.1-2 mM",2.7.7.27,C00020,9.0,30,643152,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,glgc
"pH 7, 37°C",2.7.7.41,,0.48,60,643314,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,dasyn120
"pH 7.4, 30°C",2.7.7.41,,0.59,60,643308,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,dasyn120
"pH 7, 37°C",2.7.7.41,C00458,0.75,179,643314,,-,dCTP,Escherichia coli,BRENDA,dctp,CHEBI:16311,dasyn120
"wild type enzyme, pH 6.5, 23°C",2.7.7.60,,19.6,60,661089,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,mepct
"pH 7.0, 37°C, E. coli ACP",2.7.8.7,C03688,0.0006,22286,645401,,-,Apo-[acyl-carrier-protein],Escherichia coli,BRENDA,apoacp,CHEBI:16139,acps1
"pH 7.0, 37°C, E. coli ACP",2.7.8.7,C03688,0.002,1664,645401,,-,Apo-[acyl-carrier-protein],Escherichia coli,BRENDA,apoacp,CHEBI:16139,acps1
"pH 7.2, 37°C",2.7.9.3,C00020,0.17,30,645479,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,selnps
,2.8.3.16,C00209,23.0,185,692851,,-,Oxalate,Escherichia coli,BRENDA,oxa,CHEBI:16995,forct
,3.1.3.5,C00008,1.3,13,656266,,-,ADP,Escherichia coli,BRENDA,adp,CHEBI:16761,ntd10
,3.1.3.5,C00131,1.39,140,656266,,-,dATP,Escherichia coli,BRENDA,datp,CHEBI:16284,ntd10
,3.1.3.5,C00002,1.65,4,656266,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,ntd10
"wild-type, pH 7.5, 25°C",3.1.3.5,C00020,23.0,236,664087,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,ntd10
with 3'-AMP as substrate,3.1.3.5,C00002,24.1,4,656266,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,ntd10
with 3'-AMP as substrate,3.1.3.6,C00002,24.1,4,656266,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,3ntd2pp
"wild-type, 22°C, pH 7.5",3.1.3.11,C00020,0.00062,30,665621,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,fbp
,3.1.3.11,C00009,0.35,16,651666,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,fbp
pH 7.7,3.1.3.11,,1.0,671,651666,,-,,Escherichia coli,BRENDA,f1p,CHEBI:78736,fbp
,3.1.4.16,C00020,0.59,236,652555,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,23pde2pp
"wild type enzyme, in 30 mM TES buffer, 145 mM NaCl, 0.01 mM Mg2+, pH 7.0 at 25°C",3.2.1.23,C00124,21.0,71,706624,,-,D-Galactose,Escherichia coli,BRENDA,gal,CHEBI:4139,lacz
native enzyme,3.2.1.23,C00124,24.0,71,706614,,-,D-Galactose,Escherichia coli,BRENDA,gal,CHEBI:4139,lacz
"in 50 mM potassium phosphate (pH 7.0), at 37°C",3.2.2.9,,0.0024,36,171857,,-,,Escherichia coli,BRENDA,ahcys,CHEBI:57856,ahcysns
"in 50 mM potassium phosphate (pH 7.0), at 37°C",3.2.2.9,C00147,0.3,144,171857,,-,Adenine,Escherichia coli,BRENDA,ade,CHEBI:16708,ahcysns
"pH 8.5, 37°C",3.5.4.25,C00013,0.024,17,656006,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,gtpcii2
"pH 7.5, in absence of SbIII",3.6.3.16,C00002,0.792,4,654492,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,aso3t8pp
"pH 7.5, in presence of SbIII",3.6.3.16,C00002,0.945,4,654492,,-,ATP,Escherichia coli,BRENDA,atp,CHEBI:15422,aso3t8pp
at pH 6.5 and 30°C,4.1.1.8,C00010,0.08,534,714955,,-,CoA,Escherichia coli,BRENDA,coa,CHEBI:15346,oxcdc
"uncompetitive inhibition, at pH 6.5, between 4°C and 10°C",4.1.1.18,C01228,0.0002377,3703,714832,,-,"Guanosine 3',5'-bis(diphosphate)",Escherichia coli,BRENDA,ppgpp,CHEBI:17633,lysdc
"noncompetitive inhibition, at pH 6.5, between 4°C and 10°C",4.1.1.18,C01228,0.000374,3703,714832,,-,"Guanosine 3',5'-bis(diphosphate)",Escherichia coli,BRENDA,ppgpp,CHEBI:17633,lysdc
"mixed type inhibition, at pH 6.5, between 4°C and 10°C",4.1.1.18,C01228,0.002791,3703,714832,,-,"Guanosine 3',5'-bis(diphosphate)",Escherichia coli,BRENDA,ppgpp,CHEBI:17633,lysdc
,4.1.1.23,C00105,0.5,133,649973,,-,UMP,Escherichia coli,BRENDA,ump,CHEBI:16695,ompdc
"30°C, wild-type enzyme",4.1.2.13,C00111,0.13,278,652787,,-,Glycerone phosphate,Escherichia coli,BRENDA,dhap,CHEBI:16108,fba
,4.1.2.19,C00175,1.0,23,5065,,-,Cobalt ion,Escherichia coli,BRENDA,cobalt2,CHEBI:48828,rmpa
"in 100 mM potassium phosphate buffer (pH 7.1), 10 mM MgCl2, 12 mM cysteine",4.1.3.1,C00074,0.893,51,680481,,-,Phosphoenolpyruvate,Escherichia coli,BRENDA,pep,CHEBI:44897,icl
pH 7.5,4.1.3.27,C00156,0.002,3660,650373,,-,4-Hydroxybenzoate,Escherichia coli,BRENDA,4hbz,CHEBI:30763,ans
"pH 8.0, 25°C",4.1.3.39,C00048,0.4,101,702377,,-,Glyoxylate,Escherichia coli,BRENDA,glx,CHEBI:16891,hopntal
"pH 8.0, 25°C",4.1.3.39,C00109,0.5,3288,702377,,-,2-Oxobutanoate,Escherichia coli,BRENDA,2obut,CHEBI:30831,hopntal
"pH 8.0, 25°C",4.1.3.39,C00022,0.51,31,702377,,-,Pyruvate,Escherichia coli,BRENDA,pyr,CHEBI:32816,hopntal
"pH 8.0, 25°C",4.1.3.39,C00233,6.98,722,702377,,-,4-Methyl-2-oxopentanoate,Escherichia coli,BRENDA,4mop,CHEBI:48430,hopntal
"pH 7.5, wild-type enzyme",4.1.3.40,C00156,0.0021,365,650373,,-,4-Hydroxybenzoate,Escherichia coli,BRENDA,4hbz,CHEBI:30763,chrpl
pH 7.8,4.1.99.1,,0.21,119,651028,,-,,Escherichia coli,BRENDA,trp__l,CHEBI:57912,trpas2
pH 7.8,4.1.99.1,C00073,10.3,88,651028,,-,L-Methionine,Escherichia coli,BRENDA,met__l,CHEBI:16643,trpas2
pH 7.8,4.1.99.1,,14.0,103,651028,,-,,Escherichia coli,BRENDA,ala__l,CHEBI:57972,trpas2
pH 7.8,4.1.99.1,,14.2,104,651028,,-,,Escherichia coli,BRENDA,phe__l,CHEBI:58095,trpas2
,4.2.3.1,,0.006,30785,137559,,-,,Escherichia coli,BRENDA,4hthr,CHEBI:60904,4hthrs
,4.3.1.1,C00497,0.66,1139,649266,,-,(R)-Malate,Escherichia coli,BRENDA,mal__d,CHEBI:30796,aspt
"25°C, pH 7.8",4.3.1.18,,0.035,29959,651969,,-,,Escherichia coli,BRENDA,23dappa,CHEBI:58468,serd_d
"25°C, pH 7.8",4.3.1.18,,0.09,9192,651969,,-,,Escherichia coli,BRENDA,23dappa,CHEBI:57721,serd_d
"25°C, pH 7.8",4.3.1.18,,3.0,95,651969,,-,,Escherichia coli,BRENDA,ser__l,CHEBI:33384,serd_d
"25°C, pH 7.8",4.3.1.18,,4.9,72,651969,,-,,Escherichia coli,BRENDA,gly,CHEBI:57305,serd_d
"25°C, pH 7.8",4.3.1.18,,17.0,103,651969,,-,,Escherichia coli,BRENDA,ala__l,CHEBI:57972,serd_d
,4.4.1.15,,0.53,74,648731,,-,,Escherichia coli,BRENDA,cys__l,CHEBI:35235,cysdds
,5.3.1.1,C00988,6.0,1317,2586,,-,2-Phosphoglycolate,Escherichia coli,BRENDA,2pglyc,CHEBI:17150,tpi
,5.3.1.6,C00009,8.0,16,653911,,-,Orthophosphate,Escherichia coli,BRENDA,pi,CHEBI:26078,rpi
"in presence of 0.9 mM KCl, pH 7.4, 30°C",6.1.1.1,C00013,0.056,17,650300,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,tyrtrs
"in presence of 0.5 mM KCl, pH 7.4, 30°C",6.1.1.1,C00013,0.12,17,650300,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,tyrtrs
"in absence of KCl, pH 7.4, 30°C",6.1.1.1,C00013,0.14,17,650300,,-,Diphosphate,Escherichia coli,BRENDA,ppi,CHEBI:29888,tyrtrs
"in absence of KCl, pH 7.4, 30°C",6.1.1.1,C00020,0.35,30,650300,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,tyrtrs
"in presence of 0.5 mM KCl, pH 7.4, 30°C",6.1.1.1,C00020,0.5,30,650300,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,tyrtrs
"in presence of 0.9 mM KCl, pH 7.4, 30°C",6.1.1.1,C00020,0.9,30,650300,,-,AMP,Escherichia coli,BRENDA,amp,CHEBI:16027,tyrtrs
"wild-type enzyme, pH 7.2, 37°C",6.1.1.18,C00025,96.0,1163,651246,,-,L-Glutamate,Escherichia coli,BRENDA,glu__l,CHEBI:16015,glntrs
above,6.3.1.2,C02989,5.0,4830,694057,,-,L-Methionine S-oxide,Escherichia coli,BRENDA,metsox_s__l,CHEBI:17016,glns
"37°C, Kis, noncompetitive versus ATP; 37°C, Kis, noncompetitive versus L-Asp",6.3.2.6,C00130,7.0,232,661204,,-,IMP,Escherichia coli,BRENDA,imp,CHEBI:17202,prascsi
"37°C, Kii, noncompetitive versus ATP",6.3.2.6,C00130,9.0,232,661204,,-,IMP,Escherichia coli,BRENDA,imp,CHEBI:17202,prascsi
"37°C, Kis, competitive versus 1-(5'-phosphoribosyl)-5-amino-4-carboxyimidazole",6.3.2.6,C00130,9.1,232,661204,,-,IMP,Escherichia coli,BRENDA,imp,CHEBI:17202,prascsi
"37°C, Kii, noncompetitive versus L-Asp",6.3.2.6,C00130,13.0,232,661204,,-,IMP,Escherichia coli,BRENDA,imp,CHEBI:17202,prascsi
"25°C, pH 7.8",6.3.3.3,C00147,2.2,144,653958,,-,Adenine,Escherichia coli,BRENDA,ade,CHEBI:16708,dbts
"pH 7.2, inhibition of glutamine reaction",6.3.4.2,,0.08,60,648986,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,ctps2
"pH 7.2, inhibition of ammonia reaction",6.3.4.2,,0.09,60,648986,,-,,Escherichia coli,BRENDA,ctp,CHEBI:37563,ctps2
0.2 mM guanosine,6.3.4.2,C00044,0.12,37,674909,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,ctps2
0.1 mM guanosine,6.3.4.2,C00044,0.22,37,674909,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,ctps2
no guanosine,6.3.4.2,C00044,0.28,37,674909,,-,GTP,Escherichia coli,BRENDA,gtp,CHEBI:15996,ctps2
,6.3.4.2,C00286,0.36,5697,674909,,-,dGTP,Escherichia coli,BRENDA,dgtp,CHEBI:16497,ctps2
,6.3.4.2,,0.39,33430,648963,,-,,Escherichia coli,BRENDA,glu5sa,CHEBI:58066,ctps2
,6.3.4.2,C00081,4.5,229,674909,,-,ITP,Escherichia coli,BRENDA,itp,CHEBI:16039,ctps2
"pH 7.7, 25°C, wild-type",6.3.4.4,C00042,0.89,58,652356,,-,Succinate,Escherichia coli,BRENDA,succ,CHEBI:15741,adss
,6.3.4.4,C00042,1.0,58,649423,,-,Succinate,Escherichia coli,BRENDA,succ,CHEBI:15741,adss
,6.3.5.2,C00144,0.33,162,649891,,-,GMP,Escherichia coli,BRENDA,gmp,CHEBI:17345,gmps2
"pH 8.0, 24°C",6.3.5.5,C00105,0.004,133,651292,,-,UMP,Escherichia coli,BRENDA,ump,CHEBI:16695,cbps
ReactionID=METHYLENETHFDEHYDROG-NADP-RXN,1.5.1.5,,,10-FORMYL-THF,,,-,,Escherichia Coli,EcoCyc,10fthf,CHEBI:57454,mthfd
ReactionID=METHENYLTHFCYCLOHYDRO-RXN,3.5.4.9,,,10-FORMYL-THF,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,10fthf,CHEBI:57454,mthfc
ReactionID=KDGALDOL-RXN,4.1.2.20,,,2-KETO-3-DEOXY-6-P-GLUCONATE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,2ddg6p,CHEBI:57569,glcral
ReactionID=BRANCHED-CHAINAMINOTRANSFERLEU-RXN,2.6.1.6,C00141,,2-KETO-ISOVALERATE,,,-,3-Methyl-2-oxobutanoic acid,Escherichia Coli,EcoCyc,3mob,CHEBI:11851,valta
ReactionID=PEPSYNTH-RXN,2.7.9.2,C00026,,2-KETOGLUTARATE,,,-,2-Oxoglutarate,Escherichia Coli,EcoCyc,akg,CHEBI:16810,pps
ReactionID=F16ALDOLASE-RXN,4.1.2.13,C00026,,2-KETOGLUTARATE,,,+,2-Oxoglutarate,Escherichia Coli,EcoCyc,akg,CHEBI:16810,fba
ReactionID=CITSYN-RXN,2.3.3.16,C00026,,2-KETOGLUTARATE,,COMPETITIVE,-,2-Oxoglutarate,Escherichia Coli,EcoCyc,akg,CHEBI:16810,cs
ReactionID=DEPHOSICITDEHASE-RXN,3.1.3,C00026,,2-KETOGLUTARATE,,,+,2-Oxoglutarate,Escherichia Coli,EcoCyc,akg,CHEBI:16810,pthrpp
ReactionID=SUCCINYLDIAMINOPIMTRANS-RXN,2.6.1.17,C00026,,2-KETOGLUTARATE,,,-,2-Oxoglutarate,Escherichia Coli,EcoCyc,akg,CHEBI:16810,sdpta
ReactionID=ISOCIT-CLEAV-RXN,4.1.3.1,C00026,,2-KETOGLUTARATE,,,-,2-Oxoglutarate,Escherichia Coli,EcoCyc,akg,CHEBI:16810,icl
ReactionID=DLACTDEHYDROGNAD-RXN,1.1.1.28,C00109,,2-OXOBUTANOATE,,,+,2-Oxobutanoate,Escherichia Coli,EcoCyc,2obut,CHEBI:16763,ldh_d
ReactionID=ACETOLACTSYN-RXN,2.2.1.6,C00109,,2-OXOBUTANOATE,,,-,2-Oxobutanoate,Escherichia Coli,EcoCyc,2obut,CHEBI:16763,achbs
ReactionID=DAHPSYN-RXN,2.5.1.54,,,2-PG,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,2pg,CHEBI:58289,ddpa
ReactionID=1.8.4.8-RXN,1.8.4.8,,0.004,3-5-ADP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,pap,CHEBI:58343,papsr
ReactionID=DAHPSYN-RXN,2.5.1.54,,,3-DEOXY-D-ARABINO-HEPTULOSONATE-7-P,,,-,,Escherichia Coli,EcoCyc,2dda7p,CHEBI:58394,ddpa
ReactionID=3-DEHYDROQUINATE-SYNTHASE-RXN,4.2.3.4,,,3-DEOXY-D-ARABINO-HEPTULOSONATE-7-P,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,2dda7p,CHEBI:58394,dhqs
ReactionID=2.5.1.19-RXN,2.5.1.19,,,3-ENOLPYRUVYL-SHIKIMATE-5P,,,-,,Escherichia Coli,EcoCyc,3psme,CHEBI:57701,pscvt
ReactionID=ORNDECARBOX-RXN,4.1.1.17,,,3-P-SERINE,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,pser__l,CHEBI:57524,orndc
ReactionID=PHENYLALANINE--TRNA-LIGASE-RXN,6.1.1.20,,,3-PHENYLPROPIONATE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,pppn,CHEBI:51057,phetrs
ReactionID=ASNSYNB-RXN,6.3.5.4,,5.4,3-SULFINOALANINE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,3sala,CHEBI:61085,asns1
ReactionID=P-PANTOCYSLIG-RXN,6.3.2.5,,,4-P-PANTOTHENATE,,,-,,Escherichia Coli,EcoCyc,4ppan,CHEBI:10986,ppncl2
ReactionID=THRESYN-RXN,4.2.3.1,,,4-PHOSPHONOOXY-THREONINE,,,-,,Escherichia Coli,EcoCyc,phthr,CHEBI:58452,4hthrs
ReactionID=FOLYLPOLYGLUTAMATESYNTH-RXN,6.3.2.17,,,5-METHYL-THF,,,-,,Escherichia Coli,EcoCyc,5mthf,CHEBI:18608,dhfs
ReactionID=GLYRIBONUCSYN-RXN,6.3.4.13,,,5-P-BETA-D-RIBOSYL-AMINE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,pram,CHEBI:58681,pragsr
ReactionID=AIRS-RXN,6.3.3.1,C03373,,5-PHOSPHORIBOSYL-5-AMINOIMIDAZOLE,,,-,Aminoimidazole ribotide,Escherichia Coli,EcoCyc,air,CHEBI:28843,prais
ReactionID=H2PTEROATESYNTH-RXN,2.5.1.15,C00921,,7-8-DIHYDROPTEROATE,,COMPETITIVE,-,Dihydropteroate,Escherichia Coli,EcoCyc,dhpt,CHEBI:17839,dhps2
ReactionID=FOLYLPOLYGLUTAMATESYNTH-RXN,6.3.2.17,C00921,,7-8-DIHYDROPTEROATE,,,-,Dihydropteroate,Escherichia Coli,EcoCyc,dhpt,CHEBI:17839,dhfs
ReactionID=DAPASYN-RXN,2.6.1.62,,,8-AMINO-7-OXONONANOATE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,8aonn,CHEBI:57532,amaotr
ReactionID=THIOSULFATE-SULFURTRANSFERASE-RXN,2.8.1.1,C00033,,ACET,,,-,Acetate,Escherichia Coli,EcoCyc,ac,CHEBI:30089,cyanst
ReactionID=3-DEHYDROQUINATE-DEHYDRATASE-RXN,4.2.1.10,C00033,,ACET,,COMPETITIVE,-,Acetate,Escherichia Coli,EcoCyc,ac,CHEBI:30089,dhqti
ReactionID=NAG6PDEACET-RXN,3.5.1.25,C00033,,ACET,,COMPETITIVE,-,Acetate,Escherichia Coli,EcoCyc,ac,CHEBI:30089,agdc
ReactionID=ACETYLORNDEACET-RXN,3.5.1.16,C00033,,ACET,,COMPETITIVE,-,Acetate,Escherichia Coli,EcoCyc,ac,CHEBI:30089,acoda
ReactionID=KDGALDOL-RXN,4.1.2.20,C00033,,ACET,,,-,Acetate,Escherichia Coli,EcoCyc,ac,CHEBI:30089,glcral
ReactionID=BADH-RXN,1.2.1.8,C00084,,ACETALD,,COMPETITIVE,-,Acetaldehyde,Escherichia Coli,EcoCyc,acald,CHEBI:15343,betaldhx
ReactionID=ACETYL-COA-ACETYLTRANSFER-RXN,2.3.1.9,,,ACETOACETYL-COA,,,-,,Escherichia Coli,EcoCyc,aacoa,CHEBI:57286,acact1r
ReactionID=CITSYN-RXN,2.3.3.16,,,ACETYL-COA,,ALLOSTERIC,+,,Escherichia Coli,EcoCyc,accoa,CHEBI:57288,cs
ReactionID=MALONYL-COA-ACP-TRANSACYL-RXN,2.3.1.86,,,ACETYL-COA,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,accoa,CHEBI:57288,3oar100
ReactionID=PEPCARBOX-RXN,4.1.1.31,,,ACETYL-COA,,ALLOSTERIC,+,,Escherichia Coli,EcoCyc,accoa,CHEBI:57288,ppc
ReactionID=MALIC-NADP-RXN,1.1.1.40,,,ACETYL-COA,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,accoa,CHEBI:57288,me2
ReactionID=RXN0-1382,2.8.3.16,,,ACETYL-COA,,UNCOMPETITIVE,-,,Escherichia Coli,EcoCyc,accoa,CHEBI:57288,forct
ReactionID=MALIC-NADP-RXN,1.1.1.40,,,ACETYL-P,,,+,,Escherichia Coli,EcoCyc,actp,CHEBI:22191,me2
ReactionID=THI-P-SYN-RXN,2.5.1.3,,,ACETYL-P,,,-,,Escherichia Coli,EcoCyc,actp,CHEBI:22191,tmppp
ReactionID=DAPASYN-RXN,2.6.1.62,C00147,,ADENINE,,NONCOMPETITIVE,-,Adenine,Escherichia Coli,EcoCyc,ade,CHEBI:16708,amaotr
ReactionID=RXN-16165,6.1.1.10,C00212,,ADENOSINE,,,-,Adenosine,Escherichia Coli,EcoCyc,adn,CHEBI:16335,mettrs
ReactionID=NAD-SYNTH-NH3-RXN,6.3.1.5,C00212,,ADENOSINE,,,-,Adenosine,Escherichia Coli,EcoCyc,adn,CHEBI:16335,nads1
ReactionID=DEOXYGUANPHOSPHOR-RXN,2.4.2.1,C00212,,ADENOSINE,,COMPETITIVE,-,Adenosine,Escherichia Coli,EcoCyc,adn,CHEBI:16335,punp1
ReactionID=DAPASYN-RXN,2.6.1.62,C00212,,ADENOSINE,,COMPETITIVE,-,Adenosine,Escherichia Coli,EcoCyc,adn,CHEBI:16335,amaotr
ReactionID=ACETALD-DEHYDROG-RXN,1.2.1.10,,,ADENOSINE_DIPHOSPHATE_RIBOSE,,,-,,Escherichia Coli,EcoCyc,adprib,CHEBI:57967,acald
ReactionID=2.1.1.79-RXN,2.1.1.79,,,ADENOSYL-HOMO-CYS,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,ahcys,CHEBI:57856,cfas160e
ReactionID=RXN0-2441,2.1.1.144,,,ADENOSYL-HOMO-CYS,,,-,,Escherichia Coli,EcoCyc,ahcys,CHEBI:57856,aconmt
ReactionID=PEPSYNTH-RXN,2.7.9.2,,,ADP,,,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,pps
ReactionID=PRPPAMIDOTRANS-RXN,2.4.2.14,,,ADP,,,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,gluprt
ReactionID=RXN0-3741,3.1.3.89,,,ADP,,,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,ntd1
ReactionID=GLYCEROL-KIN-RXN,2.7.1.30,,,ADP,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,glyk
ReactionID=SUCCCOASYN-RXN,6.2.1.5,,,ADP,,,+,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,sucoas
ReactionID=ADENYLATECYC-RXN,4.6.1.1,,,ADP,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,adncyc
ReactionID=F16BDEPHOS-RXN,3.1.3.11,,,ADP,,,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,fbp
ReactionID=5.1.3.20-RXN,5.1.3.20,,,ADP,,,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,agmhe
ReactionID=GLYCOGENSYN-RXN,2.4.1.21,,,ADP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,glcs1
ReactionID=THI-P-KIN-RXN,2.7.4.16,,,ADP,,,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,tmpk
ReactionID=AIRS-RXN,6.3.3.1,,,ADP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,prais
ReactionID=AIRS-RXN,6.3.3.1,,,ADP,,,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,prais
ReactionID=GLYCEROL-KIN-RXN,2.7.1.30,,,ADP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,glyk
ReactionID=1PFRUCTPHOSN-RXN,2.7.1.56,,,ADP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,fruk
ReactionID=6PFRUCTPHOS-RXN,2.7.1.11,,,ADP,,ALLOSTERIC,+,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,pfk
ReactionID=N-ACETYLGLUCOSAMINE-KINASE-RXN,2.7.1.59,,,ADP,,,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,acgamk
ReactionID=DEPHOSICITDEHASE-RXN,3.1.3,,,ADP,,,+,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,pthrpp
ReactionID=NAD-SYNTH-NH3-RXN,6.3.1.5,,,ADP,,,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,nads1
ReactionID=GLUTKIN-RXN,2.7.2.11,,0.06,ADP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,glu5k
ReactionID=PHOSACETYLTRANS-RXN,2.3.1.8,,,ADP,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,pta2
ReactionID=DETHIOBIOTIN-SYN-RXN,6.3.3.3,,,ADP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,dbts
ReactionID=NUCLEOSIDE-DIP-KIN-RXN,2.7.4.6,,,ADP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,ndpk1
ReactionID=GTP-CYCLOHYDRO-I-RXN,3.5.4.16,,0.01,ADP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,gtpci
ReactionID=GLUTAMIN-RXN,3.5.1.38,,,ADP,,,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,asnn
ReactionID=GUANOSINEKIN-RXN,2.7.1.73,,,ADP,,OTHER,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,gsnk
ReactionID=THI-P-SYN-RXN,2.5.1.3,,,ADP,,,-,,Escherichia Coli,EcoCyc,adp,CHEBI:456216,tmppp
ReactionID=5.1.3.20-RXN,5.1.3.20,,,ADP-D-GLUCOSE,,,-,,Escherichia Coli,EcoCyc,adpglc,CHEBI:57498,agmhe
ReactionID=GLYCOPHOSPHORYL-RXN,2.4.1.1,,,ADP-D-GLUCOSE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,adpglc,CHEBI:57498,glcp2
ReactionID=UDPSUGARHYDRO-RXN,3.6.1.45,,,ADP-D-GLUCOSE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,adpglc,CHEBI:57498,udpgalppp
ReactionID=FUMHYDR-RXN,4.2.1.2,,,AG+,,,-,,Escherichia Coli,EcoCyc,ag,CHEBI:49468,fum
ReactionID=GLUTAMIN-RXN,3.5.1.38,,,AG+,,,-,,Escherichia Coli,EcoCyc,ag,CHEBI:49468,asnn
ReactionID=ACETATE--COA-LIGASE-RXN,6.2.1.1,,,AMP,,,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,acs
ReactionID=PRPPSYN-RXN,2.7.6.1,,,AMP,,UNCOMPETITIVE,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,prpps
ReactionID=ARGININE--TRNA-LIGASE-RXN,6.1.1.19,,1.6,AMP,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,argtrs
ReactionID=PYRIDOXKIN-RXN,2.7.1.35,,1.3,AMP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,pydamk
ReactionID=ASNSYNA-RXN,6.3.1.1,,,AMP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,asns2
ReactionID=2.7.9.3-RXN,2.7.9.3,,0.17,AMP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,selnps
ReactionID=RIB5PISOM-RXN,5.3.1.6,,,AMP,,,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,rpi
ReactionID=THI-P-KIN-RXN,2.7.4.16,,,AMP,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,tmpk
ReactionID=RXN0-5515,2.7.7.41,,,AMP,,,+,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,dasyn120
ReactionID=PRPPAMIDOTRANS-RXN,2.4.2.14,,,AMP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,gluprt
ReactionID=FMNREDUCT-RXN,1.5.1.39,,,AMP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,fmnrx2
ReactionID=FMNREDUCT-RXN,1.5.1.39,,,AMP,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,fmnrx2
ReactionID=DEPHOSICITDEHASE-RXN,3.1.3,,,AMP,,,+,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,pthrpp
ReactionID=NAD-SYNTH-NH3-RXN,6.3.1.5,,,AMP,,,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,nads1
ReactionID=ACETALD-DEHYDROG-RXN,1.2.1.10,,,AMP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,acald
ReactionID=ACETALD-DEHYDROG-RXN,1.2.1.10,,,AMP,,,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,acald
ReactionID=GUANYL-KIN-RXN,2.7.4.8,,,AMP,,,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,dgk1
ReactionID=PEPSYNTH-RXN,2.7.9.2,,,AMP,,,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,pps
ReactionID=GLYCOPHOSPHORYL-RXN,2.4.1.1,,,AMP,,,+,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,glcp2
ReactionID=PEPDEPHOS-RXN,2.7.1.40,,,AMP,,ALLOSTERIC,+,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,pyk
ReactionID=GLUTAMIN-RXN,3.5.1.38,,,AMP,,,+,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,asnn
ReactionID=F16BDEPHOS-RXN,3.1.3.11,,,AMP,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,fbp
ReactionID=GLUTAMINESYN-RXN,6.3.1.2,,,AMP,,,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,glns
ReactionID=GLUC1PADENYLTRANS-RXN,2.7.7.27,,,AMP,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,glgc
ReactionID=ATPPHOSPHORIBOSYLTRANS-RXN,2.4.2.17,,,AMP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,amp,CHEBI:456215,atpprt
ReactionID=IGPSYN-RXN,4.1.1.48,C00108,,ANTHRANILATE,,,-,Anthranilate,Escherichia Coli,EcoCyc,anth,CHEBI:16567,igps
ReactionID=ADENYLYLSULFKIN-RXN,2.7.1.25,,,APS,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,aps,CHEBI:58243,adsk
ReactionID=RIB5PISOM-RXN,5.3.1.6,,,ARABINOSE-5P,,,-,,Escherichia Coli,EcoCyc,ara5p,CHEBI:57693,rpi
ReactionID=TRANSALDOL-RXN,2.2.1.2,,,ARABINOSE-5P,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,ara5p,CHEBI:57693,tala
ReactionID=1TRANSKETO-RXN,2.2.1.1,,,ARABINOSE-5P,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,ara5p,CHEBI:57693,tkt1
ReactionID=N-ACETYLTRANSFER-RXN,2.3.1.1,,,ARG,,,-,,Escherichia Coli,EcoCyc,arg__l,CHEBI:32682,acgs
ReactionID=AGMATIN-RXN,3.5.3.11,,,ARG,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,arg__l,CHEBI:32682,agmt
ReactionID=ABC-27-RXN,3.6.3.27,,0.023,ARSENATE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,aso4,CHEBI:48597,piuabcpp
ReactionID=METHGLYSYN-RXN,4.2.3.3,,,ARSENATE,,,-,,Escherichia Coli,EcoCyc,aso4,CHEBI:48597,mgsa
ReactionID=ASPARAGHYD-RXN,3.5.1.38,,,ASN,,ALLOSTERIC,+,,Escherichia Coli,EcoCyc,asn__l,CHEBI:58048,asnn
ReactionID=ASNSYNA-RXN,6.3.1.1,,,ASN,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,asn__l,CHEBI:58048,asns2
ReactionID=DEPHOSICITDEHASE-RXN,3.1.3,,,ATP,,,+,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,pthrpp
ReactionID=GUANOSINEKIN-RXN,2.7.1.73,,,ATP,,,+,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,gsnk
ReactionID=INOSINEKIN-RXN,2.7.1.73,,,ATP,,,+,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,gsnk
ReactionID=RXN-14126,3.1.3.6,,,ATP,,,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,3ntd2pp
ReactionID=RXN0-3741,3.1.3.89,,,ATP,,,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,ntd1
ReactionID=F16BDEPHOS-RXN,3.1.3.11,,,ATP,,,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,fbp
ReactionID=RXN0-5073,3.6.1,,,ATP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,ntp12
ReactionID=ADENYLATECYC-RXN,4.6.1.1,,,ATP,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,adncyc
ReactionID=CITSYN-RXN,2.3.3.16,,,ATP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,cs
ReactionID=6PFRUCTPHOS-RXN,2.7.1.11,,,ATP,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,pfk
ReactionID=GLYCEROL-KIN-RXN,2.7.1.30,,,ATP,,,+,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,glyk
ReactionID=DLACTDEHYDROGNAD-RXN,1.1.1.28,,,ATP,,,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,ldh_d
ReactionID=PEPCARBOXYKIN-RXN,4.1.1.49,,,ATP,,,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,ppck
ReactionID=PPGPPSYN-RXN,3.1.7.2,,,ATP,,,+,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,gdptpdp
ReactionID=RXN-9952,1.1.1.44,,,ATP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,gnd
ReactionID=LYXK-RXN,2.7.1.53,,,ATP,,,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,3kgk
ReactionID=RIBONUCLEOSIDE-DIP-REDUCTI-RXN,1.17.4.1,,,ATP,,,+,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,rndr1
ReactionID=ASPCARBTRANS-RXN,2.1.3.2,,,ATP,,ALLOSTERIC,+,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,aspct
ReactionID=METHYLENETHFDEHYDROG-NADP-RXN,1.5.1.5,,,ATP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,mthfd
ReactionID=PEPDEPHOS-RXN,2.7.1.40,,,ATP,,,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,pyk
ReactionID=PHOSACETYLTRANS-RXN,2.3.1.8,,,ATP,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,pta2
ReactionID=GMP-REDUCT-RXN,1.7.1.7,,,ATP,,,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,gmpr
ReactionID=GTP-CYCLOHYDRO-I-RXN,3.5.4.16,,0.00025,ATP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,gtpci
ReactionID=GLUTAMIN-RXN,3.5.1.38,,,ATP,,,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,asnn
ReactionID=HOMOSERDEHYDROG-RXN,1.1.1.3,,,ATP,,,+,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,hsdy
ReactionID=THI-P-SYN-RXN,2.5.1.3,,,ATP,,,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,tmppp
ReactionID=MANNONOXIDOREDUCT-RXN,1.1.1.57,,,ATP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,atp,CHEBI:30616,manao
ReactionID=GLYRIBONUCSYN-RXN,6.3.4.13,,,B-ALANINE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,ala_b,CHEBI:57966,pragsr
ReactionID=KDOTRANS2-RXN,2.4.99.13,,,BISOHMYR-GLC,,,-,,Escherichia Coli,EcoCyc,lipidads,CHEBI:58466,moat2
ReactionID=KDOTRANS-RXN,2.4.99.12,,,BISOHMYR-GLC,,,-,,Escherichia Coli,EcoCyc,lipidads,CHEBI:58466,moat
ReactionID=SAMDECARB-RXN,4.1.1.50,C00076,,CA+2,,,+,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,admdc
ReactionID=PEPCARBOXYKIN-RXN,4.1.1.49,C00076,,CA+2,,,+,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,ppck
ReactionID=TRIPHOSPHATASE-RXN,3.6.1.25,C00076,,CA+2,,,-,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,ppa2
ReactionID=RXN-9514,2.3.1.86,C00076,,CA+2,,,-,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,3oar100
ReactionID=UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN,2.3.1.191,C00076,,CA+2,,,-,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,u23gaat
ReactionID=DIHYDROFOLATEREDUCT-RXN,1.5.1.3,C00076,,CA+2,,,-,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,dhfr
ReactionID=ADENYLATECYC-RXN,4.6.1.1,C00076,,CA+2,,,-,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,adncyc
ReactionID=GLYCDEH-RXN,1.1.1.6,C00076,,CA+2,,,-,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,glycdx
ReactionID=INORGPYROPHOSPHAT-RXN,3.6.1.1,C00076,,CA+2,,COMPETITIVE,-,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,ppa
ReactionID=PHOSPHAGLYPSYN-RXN,2.7.8.5,C00076,,CA+2,,,-,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,pgsa120
ReactionID=HYPOXANPRIBOSYLTRAN-RXN,2.4.2.8,C00076,,CA+2,,,-,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,adpt
ReactionID=GDPMANDEHYDRA-RXN,4.2.1.47,C00076,,CA+2,,,+,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,gmand
ReactionID=MANNONOXIDOREDUCT-RXN,1.1.1.57,C00076,,CA+2,,,+,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,manao
ReactionID=PEPDEPHOS-RXN,2.7.1.40,C00076,,CA+2,,,-,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,pyk
ReactionID=PEPDEPHOS-RXN,2.7.1.40,C00076,,CA+2,,,+,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,pyk
ReactionID=KDO-8PPHOSPHAT-RXN,3.1.3.45,C00076,,CA+2,,,-,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,kdopp
ReactionID=ISOCIT-CLEAV-RXN,4.1.3.1,C00076,,CA+2,,,-,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,icl
ReactionID=METHYLISOCITRATE-LYASE-RXN,4.1.3.30,C00076,,CA+2,,,-,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,mcitl2
ReactionID=PRPPSYN-RXN,2.7.6.1,C00076,0.05,CA+2,,COMPETITIVE,-,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,prpps
ReactionID=DIACYLGLYKIN-RXN,2.7.1.107,C00076,,CA+2,,,-,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,dagk160
ReactionID=GLUTAMIN-RXN,3.5.1.38,C00076,,CA+2,,,+,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,asnn
ReactionID=D-PPENTOMUT-RXN,5.4.2.7,C00076,,CA+2,,,-,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,ppm2
ReactionID=325-BISPHOSPHATE-NUCLEOTIDASE-RXN,3.1.3.7,C00076,,CA+2,,,-,Calcium cation,Escherichia Coli,EcoCyc,ca2,CHEBI:29108,bpnt
ReactionID=DIHYDROFOLATEREDUCT-RXN,1.5.1.3,,,CADAVERINE,,,-,,Escherichia Coli,EcoCyc,15dap,CHEBI:58384,dhfr
ReactionID=MALIC-NADP-RXN,1.1.1.40,,,CAMP,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,camp,CHEBI:58165,me2
ReactionID=GLUTAMINESYN-RXN,6.3.1.2,,,CARBAMOYL-P,,,-,,Escherichia Coli,EcoCyc,cbp,CHEBI:58228,glns
ReactionID=ACETYLORNDEACET-RXN,3.5.1.16,C01413,,CD+2,,,-,Cadmium,Escherichia Coli,EcoCyc,cd2,CHEBI:48775,acoda
ReactionID=THREODEHYD-RXN,1.1.1.103,C01413,,CD+2,,,+,Cadmium,Escherichia Coli,EcoCyc,cd2,CHEBI:48775,thrd
ReactionID=FUMHYDR-RXN,4.2.1.2,C01413,,CD+2,,,-,Cadmium,Escherichia Coli,EcoCyc,cd2,CHEBI:48775,fum
ReactionID=ALPHAGALACTOSID-RXN,3.2.1.22,C01413,,CD+2,,,-,Cadmium,Escherichia Coli,EcoCyc,cd2,CHEBI:48775,gals3
ReactionID=N-ACETYLTRANSFER-RXN,2.3.1.1,C01413,,CD+2,,,-,Cadmium,Escherichia Coli,EcoCyc,cd2,CHEBI:48775,acgs
ReactionID=DARAB5PISOM-RXN,5.3.1.13,C01413,,CD+2,,,-,Cadmium,Escherichia Coli,EcoCyc,cd2,CHEBI:48775,a5piso
ReactionID=GLUTDECARBOX-RXN,4.1.1.15,C01413,,CD+2,,,-,Cadmium,Escherichia Coli,EcoCyc,cd2,CHEBI:48775,asp1dc
ReactionID=KDO-8PPHOSPHAT-RXN,3.1.3.45,C01413,,CD+2,,,-,Cadmium,Escherichia Coli,EcoCyc,cd2,CHEBI:48775,kdopp
ReactionID=KDO-8PSYNTH-RXN,2.5.1.55,C01413,,CD+2,,,-,Cadmium,Escherichia Coli,EcoCyc,cd2,CHEBI:48775,kdops
ReactionID=D-PPENTOMUT-RXN,5.4.2.7,C01413,,CD+2,,,-,Cadmium,Escherichia Coli,EcoCyc,cd2,CHEBI:48775,ppm2
ReactionID=DARABISOM-RXN,5.3.1.3,C01413,,CD+2,,,-,Cadmium,Escherichia Coli,EcoCyc,cd2,CHEBI:48775,fci
ReactionID=PEPCARBOX-RXN,4.1.1.31,,,CDP,,,+,,Escherichia Coli,EcoCyc,cdp,CHEBI:58069,ppc
ReactionID=BADH-RXN,1.2.1.8,C00114,,CHOLINE,,COMPETITIVE,-,Choline,Escherichia Coli,EcoCyc,chol,CHEBI:15354,betaldhx
ReactionID=ISOCIT-CLEAV-RXN,4.1.3.1,C00417,,CIS-ACONITATE,,,-,cis-Aconitate,Escherichia Coli,EcoCyc,acon_c,CHEBI:16383,icl
ReactionID=FUMHYDR-RXN,4.2.1.2,C00158,,CIT,,COMPETITIVE,-,Citrate,Escherichia Coli,EcoCyc,cit,CHEBI:16947,fum
ReactionID=F16BDEPHOS-RXN,3.1.3.11,C00158,,CIT,,,+,Citrate,Escherichia Coli,EcoCyc,cit,CHEBI:16947,fbp
ReactionID=F16ALDOLASE-RXN,4.1.2.13,C00158,,CIT,,,+,Citrate,Escherichia Coli,EcoCyc,cit,CHEBI:16947,fba
ReactionID=ASPARTASE-RXN,4.3.1.1,C00158,,CIT,,OTHER,-,Citrate,Escherichia Coli,EcoCyc,cit,CHEBI:16947,aspt
ReactionID=CHORISMATEMUT-RXN,5.4.99.5,C00158,,CIT,,COMPETITIVE,-,Citrate,Escherichia Coli,EcoCyc,cit,CHEBI:16947,chorm
ReactionID=GALACTARDEHYDRA-RXN,4.2.1.42,C00158,,CIT,,,-,Citrate,Escherichia Coli,EcoCyc,cit,CHEBI:16947,galctd
ReactionID=GLYOHMETRANS-RXN,2.1.2.1,C00698,10.0,CL-,,COMPETITIVE,-,Cl-,Escherichia Coli,EcoCyc,cl,CHEBI:17996,ghmt2r
ReactionID=3-DEHYDROQUINATE-DEHYDRATASE-RXN,4.2.1.10,C00698,,CL-,,COMPETITIVE,-,Cl-,Escherichia Coli,EcoCyc,cl,CHEBI:17996,dhqti
ReactionID=RXN0-3281,1.1.99.33,C00698,,CL-,,,-,Cl-,Escherichia Coli,EcoCyc,cl,CHEBI:17996,fhl
ReactionID=KDO-8PPHOSPHAT-RXN,3.1.3.45,C00698,,CL-,,,-,Cl-,Escherichia Coli,EcoCyc,cl,CHEBI:17996,kdopp
ReactionID=ISOCIT-CLEAV-RXN,4.1.3.1,C00698,,CL-,,,-,Cl-,Escherichia Coli,EcoCyc,cl,CHEBI:17996,icl
ReactionID=KDGALDOL-RXN,4.1.2.20,C00698,,CL-,,,-,Cl-,Escherichia Coli,EcoCyc,cl,CHEBI:17996,glcral
ReactionID=CPM-KDOSYNTH-RXN,2.7.7.38,,,CMP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,cmp,CHEBI:60377,kdoct2
ReactionID=PEPCARBOX-RXN,4.1.1.31,,,CMP,,,+,,Escherichia Coli,EcoCyc,cmp,CHEBI:60377,ppc
ReactionID=GUANOSINEKIN-RXN,2.7.1.73,,,CMP,,,+,,Escherichia Coli,EcoCyc,cmp,CHEBI:60377,gsnk
ReactionID=SAMDECARB-RXN,4.1.1.50,C00175,,CO+2,,,+,Cobalt ion,Escherichia Coli,EcoCyc,cobalt2,CHEBI:48828,admdc
ReactionID=5-NUCLEOTID-RXN,3.1.3.5,C00175,,CO+2,,,+,Cobalt ion,Escherichia Coli,EcoCyc,cobalt2,CHEBI:48828,ntd10
ReactionID=UDPSUGARHYDRO-RXN,3.6.1.45,C00175,,CO+2,,,+,Cobalt ion,Escherichia Coli,EcoCyc,cobalt2,CHEBI:48828,udpgalppp
ReactionID=CYCPHOSDIESTER-RXN,3.1.4.16,C00175,,CO+2,,,+,Cobalt ion,Escherichia Coli,EcoCyc,cobalt2,CHEBI:48828,23pde2pp
ReactionID=RXN0-299,1.14.11.17,C00175,,CO+2,,,-,Cobalt ion,Escherichia Coli,EcoCyc,cobalt2,CHEBI:48828,taudo
ReactionID=3.4.13.18-RXN,3.4.13.18,C00175,,CO+2,,,+,Cobalt ion,Escherichia Coli,EcoCyc,cobalt2,CHEBI:48828,amptasecg
ReactionID=GLUCARDEHYDRA-RXN,4.2.1.40,C00175,,CO+2,,,-,Cobalt ion,Escherichia Coli,EcoCyc,cobalt2,CHEBI:48828,glcrd
ReactionID=TETHYDPICSUCC-RXN,2.3.1.117,C00175,,CO+2,,,-,Cobalt ion,Escherichia Coli,EcoCyc,cobalt2,CHEBI:48828,thdps
ReactionID=ARGSUCCINLYA-RXN,4.3.2.1,C00175,,CO+2,,,+,Cobalt ion,Escherichia Coli,EcoCyc,cobalt2,CHEBI:48828,argsl
ReactionID=ACETYLORNDEACET-RXN,3.5.1.16,C00175,,CO+2,,,+,Cobalt ion,Escherichia Coli,EcoCyc,cobalt2,CHEBI:48828,acoda
ReactionID=KDO-8PPHOSPHAT-RXN,3.1.3.45,C00175,,CO+2,,,+,Cobalt ion,Escherichia Coli,EcoCyc,cobalt2,CHEBI:48828,kdopp
ReactionID=SULFITE-REDUCT-RXN,1.8.1.2,C00175,,CO+2,,,-,Cobalt ion,Escherichia Coli,EcoCyc,cobalt2,CHEBI:48828,sulri
ReactionID=3-NUCLEOTID-RXN,3.1.3.6,C00175,,CO+2,,,+,Cobalt ion,Escherichia Coli,EcoCyc,cobalt2,CHEBI:48828,3ntd2pp
ReactionID=OXALYL-COA-DECARBOXYLASE-RXN,4.1.1.8,,,CO-A,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,coa,CHEBI:57287,oxcdc
ReactionID=MALONYL-COA-ACP-TRANSACYL-RXN,2.3.1.86,,,CO-A,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,coa,CHEBI:57287,3oar100
ReactionID=RXN-1381,2.3.1.15,,,CO-A,,,-,,Escherichia Coli,EcoCyc,coa,CHEBI:57287,g3pat120
ReactionID=RXN-9952,1.1.1.44,,,CO-A,,,-,,Escherichia Coli,EcoCyc,coa,CHEBI:57287,gnd
ReactionID=ACP-S-ACETYLTRANSFER-RXN,2.3.1.86,,,CO-A,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,coa,CHEBI:57287,3oar100
ReactionID=3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN,2.1.2.11,,,CO-A,,,-,,Escherichia Coli,EcoCyc,coa,CHEBI:57287,mohmt
ReactionID=PANTOTHENATE-KIN-RXN,2.7.1.33,,,CO-A,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,coa,CHEBI:57287,pntk
ReactionID=MALTACETYLTRAN-RXN,2.3.1.79,,,CO-A,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,coa,CHEBI:57287,maltatr
ReactionID=RXN0-1382,2.8.3.16,,,CO-A,,,-,,Escherichia Coli,EcoCyc,coa,CHEBI:57287,forct
ReactionID=PANTEPADENYLYLTRAN-RXN,2.7.7.3,,,CO-A,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,coa,CHEBI:57287,ptpati
ReactionID=CATAL-RXN,1.11.1.6,C00177,,CPD-13584,,,-,Cyanide ion,Escherichia Coli,EcoCyc,cyan,CHEBI:17514,cat
ReactionID=SUPEROX-DISMUT-RXN,1.15.1.1,C00177,,CPD-13584,,,-,Cyanide ion,Escherichia Coli,EcoCyc,cyan,CHEBI:17514,spodm
ReactionID=2.9.1.1-RXN,2.9.1.1,C00177,,CPD-13584,,,-,Cyanide ion,Escherichia Coli,EcoCyc,cyan,CHEBI:17514,selcyss
ReactionID=PGLUCISOM-RXN,5.3.1.9,,,CPD-2961,,,-,,Escherichia Coli,EcoCyc,6pgc,CHEBI:58759,pgi
ReactionID=KDPGALDOL-RXN,4.1.2.55,,,CPD-2961,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,6pgc,CHEBI:58759,ddpgala
ReactionID=ASPARTASE-RXN,4.3.1.1,C00497,,CPD-660,,COMPETITIVE,-,(R)-Malate,Escherichia Coli,EcoCyc,mal__d,CHEBI:15588,aspt
ReactionID=RXN0-703,1.1.1.130,C00497,,CPD-660,,COMPETITIVE,-,(R)-Malate,Escherichia Coli,EcoCyc,mal__d,CHEBI:15588,dogulnr
ReactionID=DEOXYRIBOSE-P-ALD-RXN,4.1.2.4,C00479,,CPD-665,,,-,Propanal,Escherichia Coli,EcoCyc,ppal,CHEBI:17153,drpa
ReactionID=TRIOSEPISOMERIZATION-RXN,5.3.1.1,,6.0,CPD-67,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,2pglyc,CHEBI:58033,tpi
ReactionID=METHGLYSYN-RXN,4.2.3.3,,,CPD-67,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,2pglyc,CHEBI:58033,mgsa
ReactionID=RXN0-5224,4.2.1.1,C01417,,CPD-69,,,-,Cyanate,Escherichia Coli,EcoCyc,cynt,CHEBI:29195,hco3e
ReactionID=CARBPSYN-RXN,6.3.5.5,C01417,,CPD-69,,COMPETITIVE,-,Cyanate,Escherichia Coli,EcoCyc,cynt,CHEBI:29195,cbps
ReactionID=SULFITE-REDUCT-RXN,1.8.1.2,,,CPD-763,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,aso3,CHEBI:29242,sulri
ReactionID=THIOREDOXIN-REDUCT-NADPH-RXN,1.8.1.9,,,CPD-763,,,-,,Escherichia Coli,EcoCyc,aso3,CHEBI:29242,trdr
ReactionID=ADENYL-KIN-RXN,2.7.4.3,,,CPD0-1137,,,-,,Escherichia Coli,EcoCyc,ap5a,CHEBI:62041,adk1
ReactionID=GLUTRACE-RXN,5.1.1.3,,,CPD0-1456,,,+,,Escherichia Coli,EcoCyc,uama,CHEBI:83898,glur
ReactionID=UDP-NACMURALGLDAPLIG-RXN,6.3.2.13,,,CPD0-1456,,,-,,Escherichia Coli,EcoCyc,uama,CHEBI:83898,uaagds
ReactionID=CYTIDINEKIN-RXN,2.7.1,,,CTP,,,-,,Escherichia Coli,EcoCyc,ctp,CHEBI:37563,dxylk
ReactionID=RXN0-5515,2.7.7.41,,,CTP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,ctp,CHEBI:37563,dasyn120
ReactionID=CTPSYN-RXN,6.3.4.2,,,CTP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,ctp,CHEBI:37563,ctps2
ReactionID=URKI-RXN,2.7.1.48,,,CTP,,,-,,Escherichia Coli,EcoCyc,ctp,CHEBI:37563,cytdk2
ReactionID=ASPCARBTRANS-RXN,2.1.3.2,,,CTP,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,ctp,CHEBI:37563,aspct
ReactionID=GLUTAMINESYN-RXN,6.3.1.2,,,CTP,,,-,,Escherichia Coli,EcoCyc,ctp,CHEBI:37563,glns
ReactionID=THI-P-SYN-RXN,2.5.1.3,,,CTP,,,-,,Escherichia Coli,EcoCyc,ctp,CHEBI:37563,tmppp
ReactionID=RXN-15313,4.1.3.3,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,acnml
ReactionID=GLUTAMIN-RXN,3.5.1.38,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,asnn
ReactionID=INOSINEKIN-RXN,2.7.1.73,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,gsnk
ReactionID=GUANOSINEKIN-RXN,2.7.1.73,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,gsnk
ReactionID=CYCPHOSDIESTER-RXN,3.1.4.16,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,23pde2pp
ReactionID=RXN0-299,1.14.11.17,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,taudo
ReactionID=GLYCDEH-RXN,1.1.1.6,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,glycdx
ReactionID=LACTALDDEHYDROG-RXN,1.2.1.22,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,lcadi
ReactionID=N-ACETYLTRANSFER-RXN,2.3.1.1,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,acgs
ReactionID=GLUTDECARBOX-RXN,4.1.1.15,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,asp1dc
ReactionID=TETHYDPICSUCC-RXN,2.3.1.117,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,thdps
ReactionID=THREODEHYD-RXN,1.1.1.103,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,thrd
ReactionID=ACNEULY-RXN,4.1.3.3,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,acnml
ReactionID=ACETYLORNTRANSAM-RXN,2.6.1.11,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,acota
ReactionID=GLYOCARBOLIG-RXN,4.1.1.47,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,glxcl
ReactionID=GALACTUROISOM-RXN,5.3.1.12,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,gui1
ReactionID=GLUCUROISOM-RXN,5.3.1.12,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,gui1
ReactionID=GLUTSEMIALDEHYDROG-RXN,1.2.1.41,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,g5sd
ReactionID=CYTDEAM-RXN,3.5.4.1,,0.0018,CU+2,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,csnd
ReactionID=ACETYLORNDEACET-RXN,3.5.1.16,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,acoda
ReactionID=ALLANTOINASE-RXN,3.5.2.5,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,alltn
ReactionID=KDO-8PPHOSPHAT-RXN,3.1.3.45,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,kdopp
ReactionID=N-ACETYLGLUTPREDUCT-RXN,1.2.1.38,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,agpr
ReactionID=GLYCOPHOSPHORYL-RXN,2.4.1.1,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,glcp2
ReactionID=KDO-8PSYNTH-RXN,2.5.1.55,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,kdops
ReactionID=3-NUCLEOTID-RXN,3.1.3.6,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,3ntd2pp
ReactionID=D-PPENTOMUT-RXN,5.4.2.7,,,CU+2,,,-,,Escherichia Coli,EcoCyc,cu2,CHEBI:29036,ppm2
ReactionID=DCYSDESULF-RXN,4.4.1.15,,0.53,CYS,,MIXED,-,,Escherichia Coli,EcoCyc,cys__l,CHEBI:35235,cysdds
ReactionID=TRANS-RXN0-593,3.6.3.21,,,CYS,,,-,,Escherichia Coli,EcoCyc,cys__l,CHEBI:35235,argabcpp
ReactionID=7KAPSYN-RXN,2.3.1.47,,,CYS,,,-,,Escherichia Coli,EcoCyc,cys__l,CHEBI:35235,aoxsr2
ReactionID=GALACTUROISOM-RXN,5.3.1.12,,,CYS,,,-,,Escherichia Coli,EcoCyc,cys__l,CHEBI:35235,gui1
ReactionID=GLUCUROISOM-RXN,5.3.1.12,,,CYS,,,-,,Escherichia Coli,EcoCyc,cys__l,CHEBI:35235,gui1
ReactionID=HOMOSERKIN-RXN,2.7.1.39,,,CYS,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,cys__l,CHEBI:35235,hsk
ReactionID=SERINE-O-ACETTRAN-RXN,2.3.1.30,,,CYS,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,cys__l,CHEBI:35235,serat
ReactionID=DALADALALIG-RXN,6.3.2.4,,0.049,D-ALA-D-ALA,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,alaala,CHEBI:57822,alaalar
ReactionID=DALADALALIG-RXN,6.3.2.4,,0.07,D-ALA-D-ALA,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,alaala,CHEBI:57822,alaalar
ReactionID=GLYOHMETRANS-RXN,2.1.2.1,,,D-ALANINE,,,-,,Escherichia Coli,EcoCyc,ala__d,CHEBI:57416,ghmt2r
ReactionID=MANNONDEHYDRAT-RXN,4.2.1.8,C00817,,D-ALTRONATE,,,+,D-Altronate,Escherichia Coli,EcoCyc,altrn,CHEBI:17360,mnnh
ReactionID=TRANS-RXN0-593,3.6.3.21,,,D-CYSTEINE,,,+,,Escherichia Coli,EcoCyc,cys__d,CHEBI:35236,argabcpp
ReactionID=DCYSDESULF-RXN,4.4.1.15,,,D-CYSTEINE,,,-,,Escherichia Coli,EcoCyc,cys__d,CHEBI:35236,cysdds
ReactionID=GLUCARDEHYDRA-RXN,4.2.1.40,,,D-GALACTARATE,,,-,,Escherichia Coli,EcoCyc,galct__d,CHEBI:16537,glcrd
ReactionID=KDGALDOL-RXN,4.1.2.20,,,D-GALACTARATE,,OTHER,-,,Escherichia Coli,EcoCyc,galct__d,CHEBI:16537,glcral
ReactionID=GLUTDEHYD-RXN,1.4.1.4,,,D-GLT,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,glu__d,CHEBI:29986,gludy
ReactionID=GLUTAMATESYN-RXN,1.4.1.13,,,D-GLT,,,-,,Escherichia Coli,EcoCyc,glu__d,CHEBI:29986,glusy
ReactionID=KDGALDOL-RXN,4.1.2.20,C00818,,D-GLUCARATE,,OTHER,-,D-Glucarate,Escherichia Coli,EcoCyc,glcr,CHEBI:30612,glcral
ReactionID=ALTRO-OXIDOREDUCT-RXN,1.1.1.58,C00514,,D-MANNONATE,,COMPETITIVE,-,D-Mannonate,Escherichia Coli,EcoCyc,mana,CHEBI:17767,tagurr
ReactionID=MANNONDEHYDRAT-RXN,4.2.1.8,C00558,,D-TAGATURONATE,,,+,D-Tagaturonate,Escherichia Coli,EcoCyc,tagur,CHEBI:17886,mnnh
ReactionID=RXN0-384,3.6.1.19,,,DAMP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,damp,CHEBI:58245,ntpp1
ReactionID=RXN0-3741,3.1.3.89,,,DATP,,,-,,Escherichia Coli,EcoCyc,datp,CHEBI:61404,ntd1
ReactionID=TYROSINE--TRNA-LIGASE-RXN,6.1.1.1,,,DATP,,,-,,Escherichia Coli,EcoCyc,datp,CHEBI:61404,tyrtrs
ReactionID=RIBONUCLEOSIDE-DIP-REDUCTI-RXN,1.17.4.1,,,DATP,,,-,,Escherichia Coli,EcoCyc,datp,CHEBI:61404,rndr1
ReactionID=RIBONUCLEOSIDE-DIP-REDUCTI-RXN,1.17.4.1,,,DCDP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,dcdp,CHEBI:58593,rndr1
ReactionID=RXN0-3741,3.1.3.89,,,DCTP,,,-,,Escherichia Coli,EcoCyc,dctp,CHEBI:61481,ntd1
ReactionID=RXN0-5515,2.7.7.41,,,DCTP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,dctp,CHEBI:61481,dasyn120
ReactionID=3-DEHYDROQUINATE-DEHYDRATASE-RXN,4.2.1.10,C00944,,DEHYDROQUINATE,,,-,3-Dehydroquinate,Escherichia Coli,EcoCyc,3dhq,CHEBI:32364,dhqti
ReactionID=RXN0-5055,6.4.1.2,,,DETHIOBIOTIN,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,dtbt,CHEBI:57861,accoac
ReactionID=RXN0-3741,3.1.3.89,,,DGTP,,,-,,Escherichia Coli,EcoCyc,dgtp,CHEBI:61429,ntd1
ReactionID=GUANYL-KIN-RXN,2.7.4.8,,,DGTP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,dgtp,CHEBI:61429,dgk1
ReactionID=GTP-CYCLOHYDRO-I-RXN,3.5.4.16,,0.00024,DGTP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,dgtp,CHEBI:61429,gtpci
ReactionID=FOLYLPOLYGLUTAMATESYNTH-RXN,6.3.2.17,,,DIHYDROFOLATE,,,-,,Escherichia Coli,EcoCyc,dhf,CHEBI:57451,dhfs
ReactionID=H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN,3.6.1.67,,,DIHYDRONEOPTERIN-P,,,-,,Escherichia Coli,EcoCyc,dhpmp,CHEBI:58762,dntppa
ReactionID=RXN-1381,2.3.1.15,,,DIHYDROXY-ACETONE-PHOSPHATE,,MIXED,-,,Escherichia Coli,EcoCyc,dhap,CHEBI:57642,g3pat120
ReactionID=METHGLYSYN-RXN,4.2.3.3,,,DIHYDROXY-ACETONE-PHOSPHATE,,,+,,Escherichia Coli,EcoCyc,dhap,CHEBI:57642,mgsa
ReactionID=RXN-15313,4.1.3.3,C00184,,DIHYDROXYACETONE,,COMPETITIVE,-,Glycerone,Escherichia Coli,EcoCyc,dha,CHEBI:16016,acnml
ReactionID=ACNEULY-RXN,4.1.3.3,C00184,,DIHYDROXYACETONE,,COMPETITIVE,-,Glycerone,Escherichia Coli,EcoCyc,dha,CHEBI:16016,acnml
ReactionID=DTDPGLUCOSEPP-RXN,2.7.7.24,,,DTDP-D-GLUCOSE,,,-,,Escherichia Coli,EcoCyc,dtdpglu,CHEBI:57477,g1ptt
ReactionID=GLYCOPHOSPHORYL-RXN,2.4.1.1,,,DTDP-D-GLUCOSE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,dtdpglu,CHEBI:57477,glcp2
ReactionID=DTDPGLUCOSEPP-RXN,2.7.7.24,,,DTDP-RHAMNOSE,,,-,,Escherichia Coli,EcoCyc,dtdprmn,CHEBI:57510,g1ptt
ReactionID=DCTP-DEAM-RXN,3.5.4.13,,,DUTP,,,-,,Escherichia Coli,EcoCyc,dutp,CHEBI:61555,dctpd
ReactionID=FMNREDUCT-RXN,1.5.1.39,,0.0001,FAD,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,fad,CHEBI:57692,fmnrx2
ReactionID=RXN-15313,4.1.3.3,C14818,,FE+2,,,-,Fe2+,Escherichia Coli,EcoCyc,fe2,CHEBI:29033,acnml
ReactionID=SAMDECARB-RXN,4.1.1.50,C14818,,FE+2,,,+,Fe2+,Escherichia Coli,EcoCyc,fe2,CHEBI:29033,admdc
ReactionID=ALTRODEHYDRAT-RXN,4.2.1.7,C14818,,FE+2,,,+,Fe2+,Escherichia Coli,EcoCyc,fe2,CHEBI:29033,altrh
ReactionID=O-SUCCINYLBENZOATE-COA-LIG-RXN,6.2.1.26,C14818,,FE+2,,,-,Fe2+,Escherichia Coli,EcoCyc,fe2,CHEBI:29033,sucbzl
ReactionID=ACNEULY-RXN,4.1.3.3,C14818,,FE+2,,,-,Fe2+,Escherichia Coli,EcoCyc,fe2,CHEBI:29033,acnml
ReactionID=MANNONDEHYDRAT-RXN,4.2.1.8,C14818,,FE+2,,,+,Fe2+,Escherichia Coli,EcoCyc,fe2,CHEBI:29033,mnnh
ReactionID=ACETYLORNTRANSAM-RXN,2.6.1.11,C14818,,FE+2,,,-,Fe2+,Escherichia Coli,EcoCyc,fe2,CHEBI:29033,acota
ReactionID=N-ACETYLGLUTPREDUCT-RXN,1.2.1.38,C14818,,FE+2,,,-,Fe2+,Escherichia Coli,EcoCyc,fe2,CHEBI:29033,agpr
ReactionID=DAHPSYN-RXN,2.5.1.54,C14818,,FE+2,,,+,Fe2+,Escherichia Coli,EcoCyc,fe2,CHEBI:29033,ddpa
ReactionID=D-PPENTOMUT-RXN,5.4.2.7,C14818,,FE+2,,,-,Fe2+,Escherichia Coli,EcoCyc,fe2,CHEBI:29033,ppm2
ReactionID=SAMDECARB-RXN,4.1.1.50,C14819,,FE+3,,,+,Fe3+,Escherichia Coli,EcoCyc,fe3,CHEBI:29034,admdc
ReactionID=D-PPENTOMUT-RXN,5.4.2.7,C14819,,FE+3,,,-,Fe3+,Escherichia Coli,EcoCyc,fe3,CHEBI:29034,ppm2
ReactionID=3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN,2.1.2.11,C00067,,FORMALDEHYDE,,,-,Formaldehyde,Escherichia Coli,EcoCyc,fald,CHEBI:16842,mohmt
ReactionID=GLYCEROL-KIN-RXN,2.7.1.30,C00354,0.5,FRUCTOSE-16-DIPHOSPHATE,,NONCOMPETITIVE,-,"D-Fructose 1,6-bisphosphate",Escherichia Coli,EcoCyc,fdp,CHEBI:37736,glyk
ReactionID=6PFRUCTPHOS-RXN,2.7.1.11,C00354,,FRUCTOSE-16-DIPHOSPHATE,,COMPETITIVE,-,"D-Fructose 1,6-bisphosphate",Escherichia Coli,EcoCyc,fdp,CHEBI:37736,pfk
ReactionID=1PFRUCTPHOSN-RXN,2.7.1.56,C00354,,FRUCTOSE-16-DIPHOSPHATE,,,-,"D-Fructose 1,6-bisphosphate",Escherichia Coli,EcoCyc,fdp,CHEBI:37736,fruk
ReactionID=PEPCARBOX-RXN,4.1.1.31,C00354,,FRUCTOSE-16-DIPHOSPHATE,,ALLOSTERIC,+,"D-Fructose 1,6-bisphosphate",Escherichia Coli,EcoCyc,fdp,CHEBI:37736,ppc
ReactionID=RXN-9952,1.1.1.44,C00354,,FRUCTOSE-16-DIPHOSPHATE,,,-,"D-Fructose 1,6-bisphosphate",Escherichia Coli,EcoCyc,fdp,CHEBI:37736,gnd
ReactionID=PEPDEPHOS-RXN,2.7.1.40,C00354,,FRUCTOSE-16-DIPHOSPHATE,,ALLOSTERIC,+,"D-Fructose 1,6-bisphosphate",Escherichia Coli,EcoCyc,fdp,CHEBI:37736,pyk
ReactionID=GLUC1PADENYLTRANS-RXN,2.7.7.27,C00354,,FRUCTOSE-16-DIPHOSPHATE,,ALLOSTERIC,+,"D-Fructose 1,6-bisphosphate",Escherichia Coli,EcoCyc,fdp,CHEBI:37736,glgc
ReactionID=QUINOPRIBOTRANS-RXN,2.4.2.19,C00354,,FRUCTOSE-16-DIPHOSPHATE,,COMPETITIVE,-,"D-Fructose 1,6-bisphosphate",Escherichia Coli,EcoCyc,fdp,CHEBI:37736,nndpr
ReactionID=MALIC-NADP-RXN,1.1.1.40,C00122,,FUM,,,-,Fumarate,Escherichia Coli,EcoCyc,fum,CHEBI:29806,me2
ReactionID=GLUTDECARBOX-RXN,4.1.1.15,C00122,,FUM,,COMPETITIVE,-,Fumarate,Escherichia Coli,EcoCyc,fum,CHEBI:29806,asp1dc
ReactionID=METHGLYSYN-RXN,4.2.3.3,,,G3P,,,-,,Escherichia Coli,EcoCyc,3pg,CHEBI:58272,mgsa
ReactionID=DEPHOSICITDEHASE-RXN,3.1.3,,,G3P,,,+,,Escherichia Coli,EcoCyc,3pg,CHEBI:58272,pthrpp
ReactionID=ISOCIT-CLEAV-RXN,4.1.3.1,,,G3P,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,3pg,CHEBI:58272,icl
ReactionID=KDPGALDOL-RXN,4.1.2.55,,,GAP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,g3p,CHEBI:59776,ddpgala
ReactionID=PRPPAMIDOTRANS-RXN,2.4.2.14,,,GDP,,,+,,Escherichia Coli,EcoCyc,gdp,CHEBI:58189,gluprt
ReactionID=ORNDECARBOX-RXN,4.1.1.17,,,GDP,,,+,,Escherichia Coli,EcoCyc,gdp,CHEBI:58189,orndc
ReactionID=DGTPTRIPHYDRO-RXN,3.1.5.1,,,GDP,,,-,,Escherichia Coli,EcoCyc,gdp,CHEBI:58189,ntptp1
ReactionID=6PFRUCTPHOS-RXN,2.7.1.11,,,GDP,,ALLOSTERIC,+,,Escherichia Coli,EcoCyc,gdp,CHEBI:58189,pfk
ReactionID=1.1.1.271-RXN,1.1.1.271,,,GDP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,gdp,CHEBI:58189,gdmane
ReactionID=GUANYL-KIN-RXN,2.7.4.8,,,GDP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,gdp,CHEBI:58189,dgk1
ReactionID=NUCLEOSIDE-DIP-KIN-RXN,2.7.4.6,,,GDP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,gdp,CHEBI:58189,ndpk1
ReactionID=GTP-CYCLOHYDRO-I-RXN,3.5.4.16,,0.0015,GDP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,gdp,CHEBI:58189,gtpci
ReactionID=GUANOSINEKIN-RXN,2.7.1.73,,,GDP,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,gdp,CHEBI:58189,gsnk
ReactionID=GUANOSINEKIN-RXN,2.7.1.73,,,GDP,,,-,,Escherichia Coli,EcoCyc,gdp,CHEBI:58189,gsnk
ReactionID=LYSDECARBOX-RXN,4.1.1.18,C04494,,GDP-TP,,,-,Guanosine 3'-diphosphate 5'-triphosphate,Escherichia Coli,EcoCyc,gdptp,CHEBI:16690,lysdc
ReactionID=ORNDECARBOX-RXN,4.1.1.17,C04494,,GDP-TP,,,+,Guanosine 3'-diphosphate 5'-triphosphate,Escherichia Coli,EcoCyc,gdptp,CHEBI:16690,orndc
ReactionID=GLUTDEHYD-RXN,1.4.1.4,,,GLN,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,gln__l,CHEBI:58359,gludy
ReactionID=DIAMINOPIMDECARB-RXN,4.1.1.20,,,GLT,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,glu__l,CHEBI:29985,dapdc
ReactionID=MALIC-NADP-RXN,1.1.1.40,,,GLT,,,+,,Escherichia Coli,EcoCyc,glu__l,CHEBI:29985,me2
ReactionID=GLUTAMIN-RXN,3.5.1.38,,,GLT,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,glu__l,CHEBI:29985,asnn
ReactionID=L-GLN-FRUCT-6-P-AMINOTRANS-RXN,2.6.1.16,,,GLT,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,glu__l,CHEBI:29985,gf6pta
ReactionID=GLUTAMIN-RXN,3.5.1.38,,,GLT,,ALLOSTERIC,+,,Escherichia Coli,EcoCyc,glu__l,CHEBI:29985,asnn
ReactionID=MANNONDEHYDRAT-RXN,4.2.1.8,C00257,,GLUCONATE,,COMPETITIVE,-,D-Gluconic acid,Escherichia Coli,EcoCyc,glcn,CHEBI:18391,mnnh
ReactionID=FORMYLTHFDEFORMYL-RXN,3.5.1.10,C00037,,GLY,,,-,Glycine,Escherichia Coli,EcoCyc,gly,CHEBI:15428,fthfd
ReactionID=SERINE-O-ACETTRAN-RXN,2.3.1.30,C00037,,GLY,,COMPETITIVE,-,Glycine,Escherichia Coli,EcoCyc,gly,CHEBI:15428,serat
ReactionID=PGLYCDEHYDROG-RXN,1.1.1.95,C00037,,GLY,,ALLOSTERIC,-,Glycine,Escherichia Coli,EcoCyc,gly,CHEBI:15428,pgcd
ReactionID=GLUTAMINESYN-RXN,6.3.1.2,C00037,,GLY,,,-,Glycine,Escherichia Coli,EcoCyc,gly,CHEBI:15428,glns
ReactionID=BADH-RXN,1.2.1.8,C00577,,GLYCERALD,,COMPETITIVE,-,D-Glyceraldehyde,Escherichia Coli,EcoCyc,glyald,CHEBI:17378,betaldhx
ReactionID=GLYCEROL-KIN-RXN,2.7.1.30,C00116,,GLYCEROL,,,-,Glycerol,Escherichia Coli,EcoCyc,glyc,CHEBI:17754,glyk
ReactionID=GLYC3PDEHYDROGBIOSYN-RXN,1.1.1.94,,0.0044,GLYCEROL-3P,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,glyc3p,CHEBI:57597,g3pd2
ReactionID=F16ALDOLASE-RXN,4.1.2.13,,,GLYCEROL-3P,,,+,,Escherichia Coli,EcoCyc,glyc3p,CHEBI:57597,fba
ReactionID=PHOSPHAGLYPSYN-RXN,2.7.8.5,,,GLYCEROL-3P,,,-,,Escherichia Coli,EcoCyc,glyc3p,CHEBI:57597,pgsa120
ReactionID=GLYCEROL-KIN-RXN,2.7.1.30,,,GLYCEROL-3P,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,glyc3p,CHEBI:57597,glyk
ReactionID=GLYCOLALD-DEHYDROG-RXN,1.2.1.21,C00266,,GLYCOLALDEHYDE,,,-,Glycolaldehyde,Escherichia Coli,EcoCyc,gcald,CHEBI:17071,gcaldd
ReactionID=MALSYN-RXN,2.3.3.9,C00160,,GLYCOLLATE,,COMPETITIVE,-,Glycolate,Escherichia Coli,EcoCyc,glyclt,CHEBI:29805,mals
ReactionID=ISOCIT-CLEAV-RXN,4.1.3.1,C00160,,GLYCOLLATE,,,-,Glycolate,Escherichia Coli,EcoCyc,glyclt,CHEBI:29805,icl
ReactionID=PRPPAMIDOTRANS-RXN,2.4.2.14,,,GMP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,gmp,CHEBI:58115,gluprt
ReactionID=PRPPAMIDOTRANS-RXN,2.4.2.14,,,GMP,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,gmp,CHEBI:58115,gluprt
ReactionID=GUANPRIBOSYLTRAN-RXN,2.4.2.8,,,GMP,,,-,,Escherichia Coli,EcoCyc,gmp,CHEBI:58115,adpt
ReactionID=IMP-DEHYDROG-RXN,1.1.1.205,,,GMP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,gmp,CHEBI:58115,impd
ReactionID=GUANOSINEKIN-RXN,2.7.1.73,,,GMP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,gmp,CHEBI:58115,gsnk
ReactionID=HYPOXANPRIBOSYLTRAN-RXN,2.4.2.8,,,GMP,,,-,,Escherichia Coli,EcoCyc,gmp,CHEBI:58115,adpt
ReactionID=PRPPAMIDOTRANS-RXN,2.4.2.14,,,GTP,,,+,,Escherichia Coli,EcoCyc,gtp,CHEBI:37565,gluprt
ReactionID=ORNDECARBOX-RXN,4.1.1.17,,,GTP,,,+,,Escherichia Coli,EcoCyc,gtp,CHEBI:37565,orndc
ReactionID=PEPDEPHOS-RXN,2.7.1.40,,,GTP,,,-,,Escherichia Coli,EcoCyc,gtp,CHEBI:37565,pyk
ReactionID=RXN0-5073,3.6.1,,,GTP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,gtp,CHEBI:37565,ntp12
ReactionID=ADENYLATECYC-RXN,4.6.1.1,,,GTP,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,gtp,CHEBI:37565,adncyc
ReactionID=DGTPTRIPHYDRO-RXN,3.1.5.1,,,GTP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,gtp,CHEBI:37565,ntptp1
ReactionID=URACIL-PRIBOSYLTRANS-RXN,2.4.2.9,,,GTP,,,+,,Escherichia Coli,EcoCyc,gtp,CHEBI:37565,upprt
ReactionID=CTPSYN-RXN,6.3.4.2,,,GTP,,ALLOSTERIC,+,,Escherichia Coli,EcoCyc,gtp,CHEBI:37565,ctps2
ReactionID=PEPCARBOX-RXN,4.1.1.31,,,GTP,,ALLOSTERIC,+,,Escherichia Coli,EcoCyc,gtp,CHEBI:37565,ppc
ReactionID=METHYLENETHFDEHYDROG-NADP-RXN,1.5.1.5,,,GTP,,,-,,Escherichia Coli,EcoCyc,gtp,CHEBI:37565,mthfd
ReactionID=GUANYL-KIN-RXN,2.7.4.8,,,GTP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,gtp,CHEBI:37565,dgk1
ReactionID=NUCLEOSIDE-DIP-KIN-RXN,2.7.4.6,,,GTP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,gtp,CHEBI:37565,ndpk1
ReactionID=NUCLEOSIDE-DIP-KIN-RXN,2.7.4.6,,,GTP,,,-,,Escherichia Coli,EcoCyc,gtp,CHEBI:37565,ndpk1
ReactionID=GUANOSINEKIN-RXN,2.7.1.73,,,GTP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,gtp,CHEBI:37565,gsnk
ReactionID=THI-P-SYN-RXN,2.5.1.3,,,GTP,,,-,,Escherichia Coli,EcoCyc,gtp,CHEBI:37565,tmppp
ReactionID=GUANYL-KIN-RXN,2.7.4.8,C00387,,GUANOSINE,,COMPETITIVE,-,Guanosine,Escherichia Coli,EcoCyc,gsn,CHEBI:16750,dgk1
ReactionID=LYSDECARBOX-RXN,4.1.1.18,,,GUANOSINE-5DP-3DP,,,-,,Escherichia Coli,EcoCyc,ppgpp,CHEBI:77828,lysdc
ReactionID=ORNDECARBOX-RXN,4.1.1.17,,,GUANOSINE-5DP-3DP,,,+,,Escherichia Coli,EcoCyc,ppgpp,CHEBI:77828,orndc
ReactionID=URACIL-PRIBOSYLTRANS-RXN,2.4.2.9,,,GUANOSINE-5DP-3DP,,,+,,Escherichia Coli,EcoCyc,ppgpp,CHEBI:77828,upprt
ReactionID=HYPOXANPRIBOSYLTRAN-RXN,2.4.2.8,,,GUANOSINE-5DP-3DP,,,-,,Escherichia Coli,EcoCyc,ppgpp,CHEBI:77828,adpt
ReactionID=GDPPYPHOSKIN-RXN,2.7.6.5,,,GUANOSINE-5DP-3DP,,,-,,Escherichia Coli,EcoCyc,ppgpp,CHEBI:77828,gdpdpk
ReactionID=ADENYLOSUCCINATE-SYNTHASE-RXN,6.3.4.4,,,GUANOSINE-5DP-3DP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,ppgpp,CHEBI:77828,adss
ReactionID=PPPGPPHYDRO-RXN,3.6.1.40,,,GUANOSINE-5DP-3DP,,,-,,Escherichia Coli,EcoCyc,ppgpp,CHEBI:77828,gtpdpdp
ReactionID=ORNDECARBOX-RXN,4.1.1.17,,,GUANOSINE-5DP-3DP,,,-,,Escherichia Coli,EcoCyc,ppgpp,CHEBI:77828,orndc
ReactionID=THIOREDOXIN-REDUCT-NADPH-RXN,1.8.1.9,C01326,,HCN,,,-,Hydrogen cyanide,Escherichia Coli,EcoCyc,cyan,CHEBI:18407,trdr
ReactionID=GLYCOPHOSPHORYL-RXN,2.4.1.1,C01326,,HCN,,,-,Hydrogen cyanide,Escherichia Coli,EcoCyc,cyan,CHEBI:18407,glcp2
ReactionID=SULFITE-REDUCT-RXN,1.8.1.2,C01326,,HCN,,COMPETITIVE,-,Hydrogen cyanide,Escherichia Coli,EcoCyc,cyan,CHEBI:18407,sulri
ReactionID=KDGALDOL-RXN,4.1.2.20,C01326,,HCN,,,-,Hydrogen cyanide,Escherichia Coli,EcoCyc,cyan,CHEBI:18407,glcral
ReactionID=R621-RXN,1.14.12.17,C01326,,HCN,,,-,Hydrogen cyanide,Escherichia Coli,EcoCyc,cyan,CHEBI:18407,nodox
ReactionID=BADH-RXN,1.2.1.8,C00703,,HG+2,,,-,Mercury(2+),Escherichia Coli,EcoCyc,hg2,CHEBI:16793,betaldhx
ReactionID=RHAMNULPALDOL-RXN,4.1.2.19,C00703,,HG+2,,,-,Mercury(2+),Escherichia Coli,EcoCyc,hg2,CHEBI:16793,rmpa
ReactionID=ISOCIT-CLEAV-RXN,4.1.3.1,C00703,,HG+2,,,-,Mercury(2+),Escherichia Coli,EcoCyc,hg2,CHEBI:16793,icl
ReactionID=GLUTAMIN-RXN,3.5.1.38,C00703,,HG+2,,,-,Mercury(2+),Escherichia Coli,EcoCyc,hg2,CHEBI:16793,asnn
ReactionID=PGPPHOSPHA-RXN,3.1.3.27,C00703,,HG+2,,,-,Mercury(2+),Escherichia Coli,EcoCyc,hg2,CHEBI:16793,pgpp120
ReactionID=FUMHYDR-RXN,4.2.1.2,C00703,,HG+2,,,-,Mercury(2+),Escherichia Coli,EcoCyc,hg2,CHEBI:16793,fum
ReactionID=N-ACETYLTRANSFER-RXN,2.3.1.1,C00703,,HG+2,,,-,Mercury(2+),Escherichia Coli,EcoCyc,hg2,CHEBI:16793,acgs
ReactionID=DARAB5PISOM-RXN,5.3.1.13,C00703,,HG+2,,,-,Mercury(2+),Escherichia Coli,EcoCyc,hg2,CHEBI:16793,a5piso
ReactionID=GLUTDECARBOX-RXN,4.1.1.15,C00703,,HG+2,,,-,Mercury(2+),Escherichia Coli,EcoCyc,hg2,CHEBI:16793,asp1dc
ReactionID=O-SUCCINYLBENZOATE-COA-LIG-RXN,6.2.1.26,C00703,,HG+2,,,-,Mercury(2+),Escherichia Coli,EcoCyc,hg2,CHEBI:16793,sucbzl
ReactionID=THREODEHYD-RXN,1.1.1.103,C00703,,HG+2,,,-,Mercury(2+),Escherichia Coli,EcoCyc,hg2,CHEBI:16793,thrd
ReactionID=GABATRANSAM-RXN,2.6.1.19,C00703,,HG+2,,,-,Mercury(2+),Escherichia Coli,EcoCyc,hg2,CHEBI:16793,abta
ReactionID=KDO-8PPHOSPHAT-RXN,3.1.3.45,C00703,,HG+2,,,-,Mercury(2+),Escherichia Coli,EcoCyc,hg2,CHEBI:16793,kdopp
ReactionID=GLYCOPHOSPHORYL-RXN,2.4.1.1,C00703,,HG+2,,,-,Mercury(2+),Escherichia Coli,EcoCyc,hg2,CHEBI:16793,glcp2
ReactionID=KDO-8PSYNTH-RXN,2.5.1.55,C00703,,HG+2,,,-,Mercury(2+),Escherichia Coli,EcoCyc,hg2,CHEBI:16793,kdops
ReactionID=GLYOCARBOLIG-RXN,4.1.1.47,C00703,,HG+2,,,-,Mercury(2+),Escherichia Coli,EcoCyc,hg2,CHEBI:16793,glxcl
ReactionID=HISTIDPHOS-RXN,3.1.3.15,,,HIS,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,his__l,CHEBI:57595,histp
ReactionID=GLUTAMINESYN-RXN,6.3.1.2,,,HIS,,,-,,Escherichia Coli,EcoCyc,his__l,CHEBI:57595,glns
ReactionID=ATPPHOSPHORIBOSYLTRANS-RXN,2.4.2.17,,,HIS,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,his__l,CHEBI:57595,atpprt
ReactionID=HISTIDPHOS-RXN,3.1.3.15,,,HISTIDINOL,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,histd,CHEBI:57699,histp
ReactionID=HISTIDINE--TRNA-LIGASE-RXN,6.1.1.21,,,HISTIDINOL,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,histd,CHEBI:57699,histrs
ReactionID=OHMETPYRKIN-RXN,2.7.1.49,C01279,,HMP,,COMPETITIVE,-,4-Amino-5-hydroxymethyl-2-methylpyrimidine,Escherichia Coli,EcoCyc,4ahmmp,CHEBI:16892,hmpk1
ReactionID=HOMOSERKIN-RXN,2.7.1.39,,,HOMO-CYS,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,hcys__l,CHEBI:58199,hsk
ReactionID=GLUTDEHYD-RXN,1.4.1.4,,,HOMO-SER,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,hom__l,CHEBI:57476,gludy
ReactionID=HOMOSERKIN-RXN,2.7.1.39,,,HOMO-SER,,OTHER,-,,Escherichia Coli,EcoCyc,hom__l,CHEBI:57476,hsk
ReactionID=ASPARTATEKIN-RXN,2.7.2.4,,,HOMO-SER,,,+,,Escherichia Coli,EcoCyc,hom__l,CHEBI:57476,aspk
ReactionID=SUPEROX-DISMUT-RXN,1.15.1.1,C00027,,HYDROGEN-PEROXIDE,,,-,Hydrogen peroxide,Escherichia Coli,EcoCyc,h2o2,CHEBI:16240,spodm
ReactionID=CYTDEAM-RXN,3.5.4.1,C00027,,HYDROGEN-PEROXIDE,,,-,Hydrogen peroxide,Escherichia Coli,EcoCyc,h2o2,CHEBI:16240,csnd
ReactionID=ACETOLACTSYN-RXN,2.2.1.6,,,ILE,,,-,,Escherichia Coli,EcoCyc,ile__l,CHEBI:58045,achbs
ReactionID=L-ASPARTATE-OXID-RXN,1.4.3.16,,,IMINOASPARTATE,,,-,,Escherichia Coli,EcoCyc,iasp,CHEBI:58831,aspo6
ReactionID=SAICARSYN-RXN,6.3.2.6,,,IMP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,imp,CHEBI:58053,prascsi
ReactionID=PRPPAMIDOTRANS-RXN,2.4.2.14,,,IMP,,,-,,Escherichia Coli,EcoCyc,imp,CHEBI:58053,gluprt
ReactionID=HYPOXANPRIBOSYLTRAN-RXN,2.4.2.8,,,IMP,,,-,,Escherichia Coli,EcoCyc,imp,CHEBI:58053,adpt
ReactionID=CARBPSYN-RXN,6.3.5.5,,,IMP,,ALLOSTERIC,+,,Escherichia Coli,EcoCyc,imp,CHEBI:58053,cbps
ReactionID=METHYLENETHFDEHYDROG-NADP-RXN,1.5.1.5,,,IMP,,,-,,Escherichia Coli,EcoCyc,imp,CHEBI:58053,mthfd
ReactionID=GUANYL-KIN-RXN,2.7.4.8,,,IMP,,,-,,Escherichia Coli,EcoCyc,imp,CHEBI:58053,dgk1
ReactionID=NADH-DEHYDROG-A-RXN,1.6.5.3,C00238,,K+,,,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,nadh16pp
ReactionID=GTP-CYCLOHYDRO-I-RXN,3.5.4.16,C00238,,K+,,,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,gtpci
ReactionID=UDPMANNACADEHYDROG-RXN,1.1.1.336,C00238,,K+,,,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,uacmamo
ReactionID=6PFRUCTPHOS-RXN,2.7.1.11,C00238,,K+,,,-,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,pfk
ReactionID=F16ALDOLASE-RXN,4.1.2.13,C00238,,K+,,,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,fba
ReactionID=BADH-RXN,1.2.1.8,C00238,,K+,,,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,betaldhx
ReactionID=CITSYN-RXN,2.3.3.16,C00238,,K+,,OTHER,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,cs
ReactionID=GLYCDEH-RXN,1.1.1.6,C00238,,K+,,,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,glycdx
ReactionID=THI-P-KIN-RXN,2.7.4.16,C00238,,K+,,,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,tmpk
ReactionID=TREHALOSE6PSYN-RXN,2.4.1.15,C00238,,K+,,,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,tre6ps
ReactionID=DIHYDROFOLATEREDUCT-RXN,1.5.1.3,C00238,,K+,,,-,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,dhfr
ReactionID=CARBPSYN-RXN,6.3.5.5,C00238,,K+,,,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,cbps
ReactionID=IMP-DEHYDROG-RXN,1.1.1.205,C00238,,K+,,,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,impd
ReactionID=MALIC-NADP-RXN,1.1.1.40,C00238,,K+,,,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,me2
ReactionID=GLYOCARBOLIG-RXN,4.1.1.47,C00238,,K+,,,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,glxcl
ReactionID=THIKIN-RXN,2.7.1.89,C00238,,K+,,,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,tmk
ReactionID=ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN,1.2.1.11,C00238,,K+,,,-,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,asad
ReactionID=GUANYL-KIN-RXN,2.7.4.8,C00238,,K+,,,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,dgk1
ReactionID=PPPGPPHYDRO-RXN,3.6.1.40,C00238,,K+,,,-,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,gtpdpdp
ReactionID=UDPNACETYLMURAMATEDEHYDROG-RXN,1.3.1.98,C00238,,K+,,,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,uapgr
ReactionID=UDP-NACMURALGLDAPLIG-RXN,6.3.2.13,C00238,,K+,,,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,uaagds
ReactionID=HOMOSERDEHYDROG-RXN,1.1.1.3,C00238,,K+,,,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,hsdy
ReactionID=NICONUCADENYLYLTRAN-RXN,2.7.7.18,C00238,,K+,,,+,Potassium cation,Escherichia Coli,EcoCyc,k,CHEBI:29103,nmnat
ReactionID=KDGALDOL-RXN,4.1.2.20,C01187,,KDO,,COMPETITIVE,-,3-Deoxy-D-manno-octulosonate,Escherichia Coli,EcoCyc,kdo,CHEBI:16064,glcral
ReactionID=KDO-8PSYNTH-RXN,2.5.1.55,,,KDO-8P,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,kdo8p,CHEBI:58368,kdops
ReactionID=KDOTRANS2-RXN,2.4.99.13,,,KDO2-LIPID-A,,,-,,Escherichia Coli,EcoCyc,lipa,CHEBI:58540,moat2
ReactionID=KDOTRANS-RXN,2.4.99.12,,,KDO2-LIPID-A,,,-,,Escherichia Coli,EcoCyc,lipa,CHEBI:58540,moat
ReactionID=KDOTRANS2-RXN,2.4.99.13,,,KDO2-LIPID-IVA,,,-,,Escherichia Coli,EcoCyc,kdo2lipid4,CHEBI:60365,moat2
ReactionID=KDOTRANS-RXN,2.4.99.12,,,KDO2-LIPID-IVA,,,-,,Escherichia Coli,EcoCyc,kdo2lipid4,CHEBI:60365,moat
ReactionID=DAHPSYN-RXN,2.5.1.54,,,L-ALPHA-ALANINE,,,-,,Escherichia Coli,EcoCyc,ala__l,CHEBI:57972,ddpa
ReactionID=SERINE-O-ACETTRAN-RXN,2.3.1.30,,,L-ALPHA-ALANINE,,,-,,Escherichia Coli,EcoCyc,ala__l,CHEBI:57972,serat
ReactionID=GLUTAMINESYN-RXN,6.3.1.2,,,L-ALPHA-ALANINE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,ala__l,CHEBI:57972,glns
ReactionID=MALIC-NADP-RXN,1.1.1.40,,,L-ASPARTATE,,,+,,Escherichia Coli,EcoCyc,asp__l,CHEBI:29991,me2
ReactionID=ASPARAGHYD-RXN,3.5.1.38,,,L-ASPARTATE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,asp__l,CHEBI:29991,asnn
ReactionID=PEPCARBOX-RXN,4.1.1.31,,,L-ASPARTATE,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,asp__l,CHEBI:29991,ppc
ReactionID=ASPARTASE-RXN,4.3.1.1,,,L-ASPARTATE,,,+,,Escherichia Coli,EcoCyc,asp__l,CHEBI:29991,aspt
ReactionID=GLUTAMATESYN-RXN,1.4.1.13,,,L-ASPARTATE,,,-,,Escherichia Coli,EcoCyc,asp__l,CHEBI:29991,glusy
ReactionID=N-ACETYLTRANSFER-RXN,2.3.1.1,,,L-CITRULLINE,,,-,,Escherichia Coli,EcoCyc,citr__l,CHEBI:57743,acgs
ReactionID=TRANS-RXN0-593,3.6.3.21,,,L-CYSTATHIONINE,,,-,,Escherichia Coli,EcoCyc,cyst__l,CHEBI:58161,argabcpp
ReactionID=CTPSYN-RXN,6.3.4.2,,,L-GLUTAMATE_GAMMA-SEMIALDEHYDE,,OTHER,-,,Escherichia Coli,EcoCyc,glu5sa,CHEBI:58066,ctps2
ReactionID=L-GLN-FRUCT-6-P-AMINOTRANS-RXN,2.6.1.16,,,L-GLUTAMATE_GAMMA-SEMIALDEHYDE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,glu5sa,CHEBI:58066,gf6pta
ReactionID=CARBPSYN-RXN,6.3.5.5,,,L-ORNITHINE,,ALLOSTERIC,+,,Escherichia Coli,EcoCyc,orn,CHEBI:46911,cbps
ReactionID=ARGDECARBOX-RXN,4.1.1.19,,,L-ORNITHINE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,orn,CHEBI:46911,argdc
ReactionID=ACETYLORNDEACET-RXN,3.5.1.16,,,L-ORNITHINE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,orn,CHEBI:46911,acoda
ReactionID=AGMATIN-RXN,3.5.3.11,,,L-ORNITHINE,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,orn,CHEBI:46911,agmt
ReactionID=2-DEHYDROPANTOATE-REDUCT-RXN,1.1.1.169,C00522,,L-PANTOATE,,NONCOMPETITIVE,-,(R)-Pantoate,Escherichia Coli,EcoCyc,pant__r,CHEBI:15980,dpr
ReactionID=3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN,2.1.2.11,C00522,,L-PANTOATE,,,-,(R)-Pantoate,Escherichia Coli,EcoCyc,pant__r,CHEBI:15980,mohmt
ReactionID=LACTALDDEHYDROG-RXN,1.2.1.22,C00424,,LACTALD,,,-,(S)-Lactaldehyde,Escherichia Coli,EcoCyc,lald__l,CHEBI:18041,lcadi
ReactionID=LAUROYLACYLTRAN-RXN,2.3.1.241,,,LAUROYLCOA-CPD,,,-,,Escherichia Coli,EcoCyc,ddcacoa,CHEBI:57375,edtxs1
ReactionID=2-ISOPROPYLMALATESYN-RXN,2.3.3.13,,,LEU,,,-,,Escherichia Coli,EcoCyc,leu__l,CHEBI:57427,ipps
ReactionID=ACETOLACTSYN-RXN,2.2.1.6,,,LEU,,,-,,Escherichia Coli,EcoCyc,leu__l,CHEBI:57427,achbs
ReactionID=BRANCHED-CHAINAMINOTRANSFERLEU-RXN,2.6.1.6,,,LEU,,,-,,Escherichia Coli,EcoCyc,leu__l,CHEBI:57427,valta
ReactionID=ACETOOHBUTSYN-RXN,2.2.1.6,,,LEU,,,-,,Escherichia Coli,EcoCyc,leu__l,CHEBI:57427,achbs
ReactionID=ASPARTATEKIN-RXN,2.7.2.4,,,LEU,,,-,,Escherichia Coli,EcoCyc,leu__l,CHEBI:57427,aspk
ReactionID=HOMOSERKIN-RXN,2.7.1.39,,,LYS,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,lys__l,CHEBI:32551,hsk
ReactionID=ARGDECARBOX-RXN,4.1.1.19,,,LYS,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,lys__l,CHEBI:32551,argdc
ReactionID=DIAMINOPIMDECARB-RXN,4.1.1.20,,,LYS,,,-,,Escherichia Coli,EcoCyc,lys__l,CHEBI:32551,dapdc
ReactionID=ASPARTATEKIN-RXN,2.7.2.4,,,LYS,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,lys__l,CHEBI:32551,aspk
ReactionID=ASPARTATEKIN-RXN,2.7.2.4,,,LYS,,,-,,Escherichia Coli,EcoCyc,lys__l,CHEBI:32551,aspk
ReactionID=PEPCARBOX-RXN,4.1.1.31,C00149,,MAL,,ALLOSTERIC,-,(S)-Malate,Escherichia Coli,EcoCyc,mal__l,CHEBI:15589,ppc
ReactionID=TRANS-RXN0-593,3.6.3.21,,,MESO-DIAMINOPIMELATE,,,-,,Escherichia Coli,EcoCyc,26dap__m,CHEBI:57791,argabcpp
ReactionID=HOMOCYSMETB12-RXN,2.1.1.13,,,MET,,OTHER,-,,Escherichia Coli,EcoCyc,met__l,CHEBI:57844,mets
ReactionID=HOMSUCTRAN-RXN,2.3.1.46,,,MET,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,met__l,CHEBI:57844,hsst
ReactionID=FORMYLTHFDEFORMYL-RXN,3.5.1.10,,,MET,,,+,,Escherichia Coli,EcoCyc,met__l,CHEBI:57844,fthfd
ReactionID=GLUTAMATESYN-RXN,1.4.1.13,,,MET,,,-,,Escherichia Coli,EcoCyc,met__l,CHEBI:57844,glusy
ReactionID=3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN,4.1.1.98,C00132,,METOH,,,+,Methanol,Escherichia Coli,EcoCyc,meoh,CHEBI:17790,ophbdc
ReactionID=RXN-16649,3.4.16.4,C00305,,MG+2,,,-,Magnesium cation,Escherichia Coli,EcoCyc,mg2,CHEBI:18420,mddcp1pp
ReactionID=ADENYL-KIN-RXN,2.7.4.3,C00305,,MG+2,,,+,Magnesium cation,Escherichia Coli,EcoCyc,mg2,CHEBI:18420,adk1
ReactionID=TRIPHOSPHATASE-RXN,3.6.1.25,C00305,,MG+2,,,+,Magnesium cation,Escherichia Coli,EcoCyc,mg2,CHEBI:18420,ppa2
ReactionID=RXN-9514,2.3.1.86,C00305,,MG+2,,,-,Magnesium cation,Escherichia Coli,EcoCyc,mg2,CHEBI:18420,3oar100
ReactionID=UDPHYDROXYMYRGLUCOSAMNACETYLTRANS-RXN,2.3.1.191,C00305,,MG+2,,,-,Magnesium cation,Escherichia Coli,EcoCyc,mg2,CHEBI:18420,u23gaat
ReactionID=DIHYDROFOLATEREDUCT-RXN,1.5.1.3,C00305,,MG+2,,,-,Magnesium cation,Escherichia Coli,EcoCyc,mg2,CHEBI:18420,dhfr
ReactionID=RXN-1381,2.3.1.15,C00305,,MG+2,,,+,Magnesium cation,Escherichia Coli,EcoCyc,mg2,CHEBI:18420,g3pat120
ReactionID=RXN-9952,1.1.1.44,C00305,,MG+2,,,+,Magnesium cation,Escherichia Coli,EcoCyc,mg2,CHEBI:18420,gnd
ReactionID=GDPMANDEHYDRA-RXN,4.2.1.47,C00305,,MG+2,,,+,Magnesium cation,Escherichia Coli,EcoCyc,mg2,CHEBI:18420,gmand
ReactionID=MANNONOXIDOREDUCT-RXN,1.1.1.57,C00305,,MG+2,,,+,Magnesium cation,Escherichia Coli,EcoCyc,mg2,CHEBI:18420,manao
ReactionID=PRPPSYN-RXN,2.7.6.1,C00305,,MG+2,,,+,Magnesium cation,Escherichia Coli,EcoCyc,mg2,CHEBI:18420,prpps
ReactionID=GLUTAMIN-RXN,3.5.1.38,C00305,,MG+2,,,+,Magnesium cation,Escherichia Coli,EcoCyc,mg2,CHEBI:18420,asnn
ReactionID=PORPHOBILSYNTH-RXN,4.2.1.24,C00305,,MG+2,,,NIL,Magnesium cation,Escherichia Coli,EcoCyc,mg2,CHEBI:18420,ppbngs
ReactionID=GLUTAMIN-RXN,3.5.1.38,C00305,,MG+2,,,-,Magnesium cation,Escherichia Coli,EcoCyc,mg2,CHEBI:18420,asnn
ReactionID=SAMDECARB-RXN,4.1.1.50,,,MN+2,,,+,,Escherichia Coli,EcoCyc,mn2,CHEBI:29035,admdc
ReactionID=RXN-6622,3.4.13.18,,,MN+2,,,+,,Escherichia Coli,EcoCyc,mn2,CHEBI:29035,amptasecg
ReactionID=GLUCARDEHYDRA-RXN,4.2.1.40,,,MN+2,,,-,,Escherichia Coli,EcoCyc,mn2,CHEBI:29035,glcrd
ReactionID=THREODEHYD-RXN,1.1.1.103,,,MN+2,,,+,,Escherichia Coli,EcoCyc,mn2,CHEBI:29035,thrd
ReactionID=MANNONDEHYDRAT-RXN,4.2.1.8,,,MN+2,,,+,,Escherichia Coli,EcoCyc,mn2,CHEBI:29035,mnnh
ReactionID=MANNONOXIDOREDUCT-RXN,1.1.1.57,,,MN+2,,,+,,Escherichia Coli,EcoCyc,mn2,CHEBI:29035,manao
ReactionID=N-ACETYLGLUTPREDUCT-RXN,1.2.1.38,,,MN+2,,,-,,Escherichia Coli,EcoCyc,mn2,CHEBI:29035,agpr
ReactionID=GLUTAMIN-RXN,3.5.1.38,,,MN+2,,,+,,Escherichia Coli,EcoCyc,mn2,CHEBI:29035,asnn
ReactionID=ALTRODEHYDRAT-RXN,4.2.1.7,,,MN+2,,,+,,Escherichia Coli,EcoCyc,mn2,CHEBI:29035,altrh
ReactionID=GLUTAMIN-RXN,3.5.1.38,,,MN+2,,,-,,Escherichia Coli,EcoCyc,mn2,CHEBI:29035,asnn
ReactionID=2.3.1.157-RXN,2.3.1.157,,,N-ACETYL-D-GLUCOSAMINE-1-P,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,acgam1p,CHEBI:57776,g1pact
ReactionID=DIHYDROFOLATEREDUCT-RXN,1.5.1.3,C01330,,NA+,,,-,Sodium cation,Escherichia Coli,EcoCyc,na1,CHEBI:29101,dhfr
ReactionID=GLYOCARBOLIG-RXN,4.1.1.47,C01330,,NA+,,,+,Sodium cation,Escherichia Coli,EcoCyc,na1,CHEBI:29101,glxcl
ReactionID=ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN,1.2.1.11,C01330,,NA+,,,-,Sodium cation,Escherichia Coli,EcoCyc,na1,CHEBI:29101,asad
ReactionID=PPPGPPHYDRO-RXN,3.6.1.40,C01330,,NA+,,,-,Sodium cation,Escherichia Coli,EcoCyc,na1,CHEBI:29101,gtpdpdp
ReactionID=NADH-DEHYDROG-A-RXN,1.6.5.3,,,NAD,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,nad,CHEBI:57540,nadh16pp
ReactionID=ALPHAGALACTOSID-RXN,3.2.1.22,,,NAD,,,+,,Escherichia Coli,EcoCyc,nad,CHEBI:57540,gals3
ReactionID=CITSYN-RXN,2.3.3.16,,,NAD,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,nad,CHEBI:57540,cs
ReactionID=ACETALD-DEHYDROG-RXN,1.2.1.10,,,NAD,,,+,,Escherichia Coli,EcoCyc,nad,CHEBI:57540,acald
ReactionID=L-ASPARTATE-OXID-RXN,1.4.3.16,,,NAD,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,nad,CHEBI:57540,aspo6
ReactionID=3-DEHYDROQUINATE-SYNTHASE-RXN,4.2.3.4,,,NAD,,,-,,Escherichia Coli,EcoCyc,nad,CHEBI:57540,dhqs
ReactionID=GLUTAMIN-RXN,3.5.1.38,,,NAD,,,-,,Escherichia Coli,EcoCyc,nad,CHEBI:57540,asnn
ReactionID=MANNONOXIDOREDUCT-RXN,1.1.1.57,,,NAD,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,nad,CHEBI:57540,manao
ReactionID=MALIC-NADP-RXN,1.1.1.40,,,NADH,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,nadh,CHEBI:57945,me2
ReactionID=UGD-RXN,1.1.1.22,,,NADH,,,+,,Escherichia Coli,EcoCyc,nadh,CHEBI:57945,udpgd
ReactionID=CITSYN-RXN,2.3.3.16,,,NADH,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,nadh,CHEBI:57945,cs
ReactionID=NAD-KIN-RXN,2.7.1.23,,,NADH,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,nadh,CHEBI:57945,nadk
ReactionID=PHOSACETYLTRANS-RXN,2.3.1.8,,,NADH,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,nadh,CHEBI:57945,pta2
ReactionID=GLUTAMIN-RXN,3.5.1.38,,,NADH,,,-,,Escherichia Coli,EcoCyc,nadh,CHEBI:57945,asnn
ReactionID=LACTALDDEHYDROG-RXN,1.2.1.22,,,NADH,,,-,,Escherichia Coli,EcoCyc,nadh,CHEBI:57945,lcadi
ReactionID=MALIC-NADP-RXN,1.1.1.40,,,NADP,,,-,,Escherichia Coli,EcoCyc,nadp,CHEBI:58349,me2
ReactionID=FMNREDUCT-RXN,1.5.1.39,,,NADP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,nadp,CHEBI:58349,fmnrx2
ReactionID=FMNREDUCT-RXN,1.5.1.39,,,NADP,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,nadp,CHEBI:58349,fmnrx2
ReactionID=RXN-9952,1.1.1.44,,,NADP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,nadp,CHEBI:58349,gnd
ReactionID=1.1.1.271-RXN,1.1.1.271,,,NADP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,nadp,CHEBI:58349,gdmane
ReactionID=2-DEHYDROPANTOATE-REDUCT-RXN,1.1.1.169,,,NADP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,nadp,CHEBI:58349,dpr
ReactionID=SULFITE-REDUCT-RXN,1.8.1.2,,,NADP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,nadp,CHEBI:58349,sulri
ReactionID=GLUTAMIN-RXN,3.5.1.38,,,NADP,,,-,,Escherichia Coli,EcoCyc,nadp,CHEBI:58349,asnn
ReactionID=PYRROLINECARBREDUCT-RXN,1.5.1.2,,0.6,NADP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,nadp,CHEBI:58349,p5cr
ReactionID=ACETOLACTREDUCTOISOM-RXN,1.1.1.86,,,NADP,,,-,,Escherichia Coli,EcoCyc,nadp,CHEBI:58349,kara1
ReactionID=DEPHOSICITDEHASE-RXN,3.1.3,,,NADPH,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,nadph,CHEBI:57783,pthrpp
ReactionID=NAD-KIN-RXN,2.7.1.23,,,NADPH,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,nadph,CHEBI:57783,nadk
ReactionID=PHOSACETYLTRANS-RXN,2.3.1.8,,,NADPH,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,nadph,CHEBI:57783,pta2
ReactionID=GLUTAMIN-RXN,3.5.1.38,,,NADPH,,,-,,Escherichia Coli,EcoCyc,nadph,CHEBI:57783,asnn
ReactionID=GLUTATHIONE-REDUCT-NADPH-RXN,1.8.1.7,,,NADPH,,,-,,Escherichia Coli,EcoCyc,nadph,CHEBI:57783,gthor
ReactionID=GLUTSEMIALDEHYDROG-RXN,1.2.1.41,,,NI+2,,,-,,Escherichia Coli,EcoCyc,ni2,CHEBI:49786,g5sd
ReactionID=RXN-6622,3.4.13.18,,,NI+2,,,+,,Escherichia Coli,EcoCyc,ni2,CHEBI:49786,amptasecg
ReactionID=F16ALDOLASE-RXN,4.1.2.13,,,NI+2,,,-,,Escherichia Coli,EcoCyc,ni2,CHEBI:49786,fba
ReactionID=ALPHAGALACTOSID-RXN,3.2.1.22,,,NI+2,,,-,,Escherichia Coli,EcoCyc,ni2,CHEBI:49786,gals3
ReactionID=THREODEHYD-RXN,1.1.1.103,,,NI+2,,,-,,Escherichia Coli,EcoCyc,ni2,CHEBI:49786,thrd
ReactionID=ARGSUCCINLYA-RXN,4.3.2.1,,,NI+2,,,+,,Escherichia Coli,EcoCyc,ni2,CHEBI:49786,argsl
ReactionID=ACETYLORNDEACET-RXN,3.5.1.16,,,NI+2,,,-,,Escherichia Coli,EcoCyc,ni2,CHEBI:49786,acoda
ReactionID=N-ACETYLGLUTPREDUCT-RXN,1.2.1.38,,,NI+2,,,-,,Escherichia Coli,EcoCyc,ni2,CHEBI:49786,agpr
ReactionID=QUINOPRIBOTRANS-RXN,2.4.2.19,,,NICOTINATE_NUCLEOTIDE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,nicrnt,CHEBI:57502,nndpr
ReactionID=RXN0-3281,1.1.99.33,,,NITRATE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,no3,CHEBI:17632,fhl
ReactionID=GLYCOPHOSPHORYL-RXN,2.4.1.1,,,NITRATE,,,-,,Escherichia Coli,EcoCyc,no3,CHEBI:17632,glcp2
ReactionID=KDGALDOL-RXN,4.1.2.20,,,NITRATE,,,-,,Escherichia Coli,EcoCyc,no3,CHEBI:17632,glcral
ReactionID=RXN0-3281,1.1.99.33,C00088,,NITRITE,,,-,Nitrite,Escherichia Coli,EcoCyc,no2,CHEBI:16301,fhl
ReactionID=RXN-15313,4.1.3.3,C00168,,OH-PYR,,IRREVERSIBLE,-,Hydroxypyruvate,Escherichia Coli,EcoCyc,hpyr,CHEBI:17180,acnml
ReactionID=ACNEULY-RXN,4.1.3.3,C00168,,OH-PYR,,IRREVERSIBLE,-,Hydroxypyruvate,Escherichia Coli,EcoCyc,hpyr,CHEBI:17180,acnml
ReactionID=PEPSYNTH-RXN,2.7.9.2,C00036,,OXALACETIC_ACID,,,-,Oxaloacetate,Escherichia Coli,EcoCyc,oaa,CHEBI:16452,pps
ReactionID=CITSYN-RXN,2.3.3.16,C00036,,OXALACETIC_ACID,,ALLOSTERIC,-,Oxaloacetate,Escherichia Coli,EcoCyc,oaa,CHEBI:16452,cs
ReactionID=ISOCITDEH-RXN,1.1.1.42,C00036,,OXALACETIC_ACID,,COMPETITIVE,-,Oxaloacetate,Escherichia Coli,EcoCyc,oaa,CHEBI:16452,icdhyr
ReactionID=DEPHOSICITDEHASE-RXN,3.1.3,C00036,,OXALACETIC_ACID,,,+,Oxaloacetate,Escherichia Coli,EcoCyc,oaa,CHEBI:16452,pthrpp
ReactionID=MALIC-NADP-RXN,1.1.1.40,C00036,,OXALACETIC_ACID,,ALLOSTERIC,-,Oxaloacetate,Escherichia Coli,EcoCyc,oaa,CHEBI:16452,me2
ReactionID=CITLY-RXN,4.1.3.6,C00036,,OXALACETIC_ACID,,,-,Oxaloacetate,Escherichia Coli,EcoCyc,oaa,CHEBI:16452,citl
ReactionID=PEPSYNTH-RXN,2.7.9.2,C00209,,OXALATE,,,-,Oxalate,Escherichia Coli,EcoCyc,oxa,CHEBI:30623,pps
ReactionID=MALSYN-RXN,2.3.3.9,C00209,0.037,OXALATE,,COMPETITIVE,-,Oxalate,Escherichia Coli,EcoCyc,oxa,CHEBI:30623,mals
ReactionID=GLUTDECARBOX-RXN,4.1.1.15,C00209,,OXALATE,,COMPETITIVE,-,Oxalate,Escherichia Coli,EcoCyc,oxa,CHEBI:30623,asp1dc
ReactionID=MALSYN-RXN,2.3.3.9,C00209,,OXALATE,,COMPETITIVE,-,Oxalate,Escherichia Coli,EcoCyc,oxa,CHEBI:30623,mals
ReactionID=ISOCIT-CLEAV-RXN,4.1.3.1,C00209,,OXALATE,,COMPETITIVE,-,Oxalate,Escherichia Coli,EcoCyc,oxa,CHEBI:30623,icl
ReactionID=RXN0-1382,2.8.3.16,C00209,,OXALATE,,,-,Oxalate,Escherichia Coli,EcoCyc,oxa,CHEBI:30623,forct
ReactionID=DLACTDEHYDROGNAD-RXN,1.1.1.28,,,OXAMATE,,MIXED,-,,Escherichia Coli,EcoCyc,oxam,CHEBI:58363,ldh_d
ReactionID=GLUTATHIONE-REDUCT-NADPH-RXN,1.8.1.7,,,OXIDIZED-GLUTATHIONE,,,-,,Escherichia Coli,EcoCyc,gthox,CHEBI:58297,gthor
ReactionID=PYRUVFORMLY-RXN,2.3.1.54,C00007,,OXYGEN-MOLECULE,,IRREVERSIBLE,-,Oxygen,Escherichia Coli,EcoCyc,o2,CHEBI:15379,obtfl
ReactionID=RXN0-3281,1.1.99.33,C00007,,OXYGEN-MOLECULE,,,-,Oxygen,Escherichia Coli,EcoCyc,o2,CHEBI:15379,fhl
ReactionID=QUINOLINATE-SYNTHA-RXN,2.5.1.72,C00007,,OXYGEN-MOLECULE,,,-,Oxygen,Escherichia Coli,EcoCyc,o2,CHEBI:15379,qulns
ReactionID=S-ADENMETSYN-RXN,2.5.1.6,C00536,,P3I,,COMPETITIVE,-,Triphosphate,Escherichia Coli,EcoCyc,pppi,CHEBI:18036,metat
ReactionID=GLUTAMIN-RXN,3.5.1.38,C00536,,P3I,,,+,Triphosphate,Escherichia Coli,EcoCyc,pppi,CHEBI:18036,asnn
ReactionID=GLYC3PDEHYDROGBIOSYN-RXN,1.1.1.94,,0.001,PALMITYL-COA,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,pmtcoa,CHEBI:57379,g3pd2
ReactionID=RXN-9657,1.3.1.9,,,PALMITYL-COA,,,-,,Escherichia Coli,EcoCyc,pmtcoa,CHEBI:57379,ear121x
ReactionID=3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN,2.1.2.11,C00864,,PANTOTHENATE,,,-,Pantothenate,Escherichia Coli,EcoCyc,pnto__r,CHEBI:29032,mohmt
ReactionID=ADENYLYLSULFKIN-RXN,2.7.1.25,,,PAPS,,,-,,Escherichia Coli,EcoCyc,paps,CHEBI:58339,adsk
ReactionID=DAHPSYN-RXN,2.5.1.54,,,PHE,,,-,,Escherichia Coli,EcoCyc,phe__l,CHEBI:58095,ddpa
ReactionID=CHORISMATEMUT-RXN,5.4.99.5,,,PHE,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,phe__l,CHEBI:58095,chorm
ReactionID=BADH-RXN,1.2.1.8,C00601,,PHENYLACETALDEHYDE,,COMPETITIVE,-,Phenylacetaldehyde,Escherichia Coli,EcoCyc,pacald,CHEBI:16424,betaldhx
ReactionID=ISOCITDEH-RXN,1.1.1.42,,,PHOSPHO-ENOL-PYRUVATE,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,pep,CHEBI:58702,icdhyr
ReactionID=PGLUCISOM-RXN,5.3.1.9,,,PHOSPHO-ENOL-PYRUVATE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,pep,CHEBI:58702,pgi
ReactionID=PHOSACETYLTRANS-RXN,2.3.1.8,,,PHOSPHO-ENOL-PYRUVATE,,,+,,Escherichia Coli,EcoCyc,pep,CHEBI:58702,pta2
ReactionID=PHOSACETYLTRANS-RXN,2.3.1.8,,,PHOSPHO-ENOL-PYRUVATE,,,-,,Escherichia Coli,EcoCyc,pep,CHEBI:58702,pta2
ReactionID=2.5.1.19-RXN,2.5.1.19,,,PHOSPHO-ENOL-PYRUVATE,,,+,,Escherichia Coli,EcoCyc,pep,CHEBI:58702,pscvt
ReactionID=ISOCIT-CLEAV-RXN,4.1.3.1,,,PHOSPHO-ENOL-PYRUVATE,,UNCOMPETITIVE,-,,Escherichia Coli,EcoCyc,pep,CHEBI:58702,icl
ReactionID=F16BDEPHOS-RXN,3.1.3.11,,,PHOSPHO-ENOL-PYRUVATE,,,+,,Escherichia Coli,EcoCyc,pep,CHEBI:58702,fbp
ReactionID=F16ALDOLASE-RXN,4.1.2.13,,,PHOSPHO-ENOL-PYRUVATE,,,+,,Escherichia Coli,EcoCyc,pep,CHEBI:58702,fba
ReactionID=METHGLYSYN-RXN,4.2.3.3,,,PHOSPHO-ENOL-PYRUVATE,,,-,,Escherichia Coli,EcoCyc,pep,CHEBI:58702,mgsa
ReactionID=PEPCARBOXYKIN-RXN,4.1.1.49,,,PHOSPHO-ENOL-PYRUVATE,,,-,,Escherichia Coli,EcoCyc,pep,CHEBI:58702,ppck
ReactionID=6PFRUCTPHOS-RXN,2.7.1.11,,,PHOSPHO-ENOL-PYRUVATE,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,pep,CHEBI:58702,pfk
ReactionID=DEPHOSICITDEHASE-RXN,3.1.3,,,PHOSPHO-ENOL-PYRUVATE,,,+,,Escherichia Coli,EcoCyc,pep,CHEBI:58702,pthrpp
ReactionID=PEPSYNTH-RXN,2.7.9.2,,,PHOSPHO-ENOL-PYRUVATE,,,-,,Escherichia Coli,EcoCyc,pep,CHEBI:58702,pps
ReactionID=F16BDEPHOS-RXN,3.1.3.11,,,PHOSPHO-ENOL-PYRUVATE,,,-,,Escherichia Coli,EcoCyc,pep,CHEBI:58702,fbp
ReactionID=THI-P-SYN-RXN,2.5.1.3,,,PHOSPHO-ENOL-PYRUVATE,,,-,,Escherichia Coli,EcoCyc,pep,CHEBI:58702,tmppp
ReactionID=ACETATE--COA-LIGASE-RXN,6.2.1.1,C00013,,PPI,,,-,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,acs
ReactionID=ARGININE--TRNA-LIGASE-RXN,6.1.1.19,C00013,0.1,PPI,,NONCOMPETITIVE,-,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,argtrs
ReactionID=ADENYLATECYC-RXN,4.6.1.1,C00013,,PPI,,NONCOMPETITIVE,-,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,adncyc
ReactionID=METHGLYSYN-RXN,4.2.3.3,C00013,,PPI,,COMPETITIVE,-,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,mgsa
ReactionID=THI-P-KIN-RXN,2.7.4.16,C00013,,PPI,,,-,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,tmpk
ReactionID=RXN0-384,3.6.1.19,C00013,,PPI,,COMPETITIVE,-,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,ntpp1
ReactionID=GTP-CYCLOHYDRO-II-RXN,3.5.4.25,C00013,,PPI,,COMPETITIVE,-,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,gtpcii2
ReactionID=ASPARTASE-RXN,4.3.1.1,C00013,,PPI,,OTHER,-,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,aspt
ReactionID=GMP-SYN-GLUT-RXN,6.3.5.2,C00013,,PPI,,COMPETITIVE,-,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,gmps2
ReactionID=H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN,3.6.1.67,C00013,,PPI,,,-,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,dntppa
ReactionID=NUCLEOSIDE-DIP-KIN-RXN,2.7.4.6,C00013,,PPI,,,-,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,ndpk1
ReactionID=KDGALDOL-RXN,4.1.2.20,C00013,,PPI,,,-,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,glcral
ReactionID=DTDPGLUCOSEPP-RXN,2.7.7.24,C00013,,PPI,,,-,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,g1ptt
ReactionID=GLUTAMIN-RXN,3.5.1.38,C00013,,PPI,,,+,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,asnn
ReactionID=GALACTARDEHYDRA-RXN,4.2.1.42,C00013,,PPI,,,-,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,galctd
ReactionID=GLUC1PADENYLTRANS-RXN,2.7.7.27,C00013,,PPI,,,-,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,glgc
ReactionID=THI-P-SYN-RXN,2.5.1.3,C00013,,PPI,,,-,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,tmppp
ReactionID=QUINOPRIBOTRANS-RXN,2.4.2.19,C00013,,PPI,,NONCOMPETITIVE,-,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,nndpr
ReactionID=S-ADENMETSYN-RXN,2.5.1.6,C00013,,PPI,,NONCOMPETITIVE,-,Diphosphate,Escherichia Coli,EcoCyc,ppi,CHEBI:29888,metat
ReactionID=CHORISMATEMUT-RXN,5.4.99.5,C00254,,PREPHENATE,,,-,Prephenate,Escherichia Coli,EcoCyc,pphn,CHEBI:29934,chorm
ReactionID=CHORISMATEMUT-RXN,5.4.99.5,C00254,,PREPHENATE,,COMPETITIVE,-,Prephenate,Escherichia Coli,EcoCyc,pphn,CHEBI:29934,chorm
ReactionID=GLUTKIN-RXN,2.7.2.11,,,PRO,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,pro__l,CHEBI:60039,glu5k
ReactionID=PYRROLINECARBREDUCT-RXN,1.5.1.2,,15.0,PRO,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,pro__l,CHEBI:60039,p5cr
ReactionID=ACETATE--COA-LIGASE-RXN,6.2.1.1,C00163,,PROPIONATE,,COMPETITIVE,-,Propanoate,Escherichia Coli,EcoCyc,ppa,CHEBI:17272,acs
ReactionID=CITSYN-RXN,2.3.3.16,,,PROPIONYL-COA,,,-,,Escherichia Coli,EcoCyc,ppcoa,CHEBI:57392,cs
ReactionID=RXN0-1461,1.3.3.3,,,PROTOPORPHYRIN_IX,,,-,,Escherichia Coli,EcoCyc,ppp9,CHEBI:57306,cpppgo
ReactionID=DIHYDROFOLATEREDUCT-RXN,1.5.1.3,,,PUTRESCINE,,,-,,Escherichia Coli,EcoCyc,ptrc,CHEBI:326268,dhfr
ReactionID=LYSDECARBOX-RXN,4.1.1.18,,,PUTRESCINE,,,-,,Escherichia Coli,EcoCyc,ptrc,CHEBI:326268,lysdc
ReactionID=ORNDECARBOX-RXN,4.1.1.17,,,PUTRESCINE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,ptrc,CHEBI:326268,orndc
ReactionID=ARGDECARBOX-RXN,4.1.1.19,,,PUTRESCINE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,ptrc,CHEBI:326268,argdc
ReactionID=PYRIDOXKIN-RXN,2.7.1.35,C00250,,PYRIDOXAL,,,-,Pyridoxal,Escherichia Coli,EcoCyc,pydx,CHEBI:17310,pydamk
ReactionID=GLUC1PADENYLTRANS-RXN,2.7.7.27,,,PYRIDOXAL_PHOSPHATE,,,+,,Escherichia Coli,EcoCyc,pydx5p,CHEBI:597326,glgc
ReactionID=PMPOXI-RXN,1.4.3.5,,,PYRIDOXAL_PHOSPHATE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,pydx5p,CHEBI:597326,pdx5poi
ReactionID=PYRIDOXKIN-RXN,2.7.1.35,,,PYRIDOXAL_PHOSPHATE,,,-,,Escherichia Coli,EcoCyc,pydx5p,CHEBI:597326,pydamk
ReactionID=2.5.1.19-RXN,2.5.1.19,,,PYRIDOXAL_PHOSPHATE,,,-,,Escherichia Coli,EcoCyc,pydx5p,CHEBI:597326,pscvt
ReactionID=L-GLN-FRUCT-6-P-AMINOTRANS-RXN,2.6.1.16,,,PYRIDOXAL_PHOSPHATE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,pydx5p,CHEBI:597326,gf6pta
ReactionID=L-GLN-FRUCT-6-P-AMINOTRANS-RXN,2.6.1.16,,,PYRIDOXAL_PHOSPHATE,,,-,,Escherichia Coli,EcoCyc,pydx5p,CHEBI:597326,gf6pta
ReactionID=PNPOXI-RXN,1.4.3.5,,,PYRIDOXAL_PHOSPHATE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,pydx5p,CHEBI:597326,pdx5poi
ReactionID=ERYTH4PDEHYDROG-RXN,1.2.1.72,,,PYRIDOXAL_PHOSPHATE,,,-,,Escherichia Coli,EcoCyc,pydx5p,CHEBI:597326,e4pd
ReactionID=OHMETPYRKIN-RXN,2.7.1.49,C00314,0.0027,PYRIDOXINE,,COMPETITIVE,-,Pyridoxine,Escherichia Coli,EcoCyc,pydxn,CHEBI:16709,hmpk1
ReactionID=OHMETPYRKIN-RXN,2.7.1.49,C00314,,PYRIDOXINE,,COMPETITIVE,-,Pyridoxine,Escherichia Coli,EcoCyc,pydxn,CHEBI:16709,hmpk1
ReactionID=PNPOXI-RXN,1.4.3.5,,,PYRIDOXINE-5P,,,-,,Escherichia Coli,EcoCyc,pdx5p,CHEBI:58589,pdx5poi
ReactionID=RXN-15313,4.1.3.3,C00022,,PYRUVATE,,COMPETITIVE,-,Pyruvate,Escherichia Coli,EcoCyc,pyr,CHEBI:15361,acnml
ReactionID=PHOSACETYLTRANS-RXN,2.3.1.8,C00022,,PYRUVATE,,,+,Pyruvate,Escherichia Coli,EcoCyc,pyr,CHEBI:15361,pta2
ReactionID=PHOSACETYLTRANS-RXN,2.3.1.8,C00022,,PYRUVATE,,,-,Pyruvate,Escherichia Coli,EcoCyc,pyr,CHEBI:15361,pta2
ReactionID=2.5.1.19-RXN,2.5.1.19,C00022,,PYRUVATE,,,-,Pyruvate,Escherichia Coli,EcoCyc,pyr,CHEBI:15361,pscvt
ReactionID=MALSYN-RXN,2.3.3.9,C00022,0.65,PYRUVATE,,COMPETITIVE,-,Pyruvate,Escherichia Coli,EcoCyc,pyr,CHEBI:15361,mals
ReactionID=DLACTDEHYDROGNAD-RXN,1.1.1.28,C00022,,PYRUVATE,,ALLOSTERIC,+,Pyruvate,Escherichia Coli,EcoCyc,pyr,CHEBI:15361,ldh_d
ReactionID=ACNEULY-RXN,4.1.3.3,C00022,,PYRUVATE,,COMPETITIVE,-,Pyruvate,Escherichia Coli,EcoCyc,pyr,CHEBI:15361,acnml
ReactionID=DEPHOSICITDEHASE-RXN,3.1.3,C00022,,PYRUVATE,,,+,Pyruvate,Escherichia Coli,EcoCyc,pyr,CHEBI:15361,pthrpp
ReactionID=3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN,2.1.2.11,C00022,,PYRUVATE,,,-,Pyruvate,Escherichia Coli,EcoCyc,pyr,CHEBI:15361,mohmt
ReactionID=MALSYN-RXN,2.3.3.9,C00022,,PYRUVATE,,,-,Pyruvate,Escherichia Coli,EcoCyc,pyr,CHEBI:15361,mals
ReactionID=D-PPENTOMUT-RXN,5.4.2.7,,,RIBOSE-15-BISPHOSPHATE,,,+,,Escherichia Coli,EcoCyc,r15bp,CHEBI:68688,ppm2
ReactionID=RXN-9952,1.1.1.44,,,RIBULOSE-5P,,,-,,Escherichia Coli,EcoCyc,ru5p__d,CHEBI:58121,gnd
ReactionID=SAMDECARB-RXN,4.1.1.50,,,S-ADENOSYLMETHIONINAMINE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,ametam,CHEBI:57443,admdc
ReactionID=HOMSUCTRAN-RXN,2.3.1.46,,,S-ADENOSYLMETHIONINE,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,amet,CHEBI:59789,hsst
ReactionID=S-ADENMETSYN-RXN,2.5.1.6,,,S-ADENOSYLMETHIONINE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,amet,CHEBI:59789,metat
ReactionID=SERINE-O-ACETTRAN-RXN,2.3.1.30,,,SER,,,-,,Escherichia Coli,EcoCyc,ser__l,CHEBI:33384,serat
ReactionID=PGLYCDEHYDROG-RXN,1.1.1.95,,,SER,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,ser__l,CHEBI:33384,pgcd
ReactionID=RXN0-5114,3.1.3.3,,,SER,,,-,,Escherichia Coli,EcoCyc,ser__l,CHEBI:33384,psp_l
ReactionID=GLUTAMINESYN-RXN,6.3.1.2,,,SER,,,-,,Escherichia Coli,EcoCyc,ser__l,CHEBI:33384,glns
ReactionID=THIOSULFATE-SULFURTRANSFERASE-RXN,2.8.1.1,,,SO3,,,-,,Escherichia Coli,EcoCyc,so3,CHEBI:17359,cyanst
ReactionID=LYSDECARBOX-RXN,4.1.1.18,,,SPERMIDINE,,,-,,Escherichia Coli,EcoCyc,spmd,CHEBI:57834,lysdc
ReactionID=DIHYDROFOLATEREDUCT-RXN,1.5.1.3,,,SPERMIDINE,,,-,,Escherichia Coli,EcoCyc,spmd,CHEBI:57834,dhfr
ReactionID=SAMDECARB-RXN,4.1.1.50,,,SPERMIDINE,,,-,,Escherichia Coli,EcoCyc,spmd,CHEBI:57834,admdc
ReactionID=RXN-1381,2.3.1.15,,,SPERMIDINE,,,+,,Escherichia Coli,EcoCyc,spmd,CHEBI:57834,g3pat120
ReactionID=ARGDECARBOX-RXN,4.1.1.19,,,SPERMIDINE,,,-,,Escherichia Coli,EcoCyc,spmd,CHEBI:57834,argdc
ReactionID=SPERMIDINESYN-RXN,2.5.1.16,,,SPERMIDINE,,,-,,Escherichia Coli,EcoCyc,spmd,CHEBI:57834,apcs
ReactionID=ARGDECARBOX-RXN,4.1.1.19,,,SPERMIDINE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,spmd,CHEBI:57834,argdc
ReactionID=ORNDECARBOX-RXN,4.1.1.17,,,SPERMIDINE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,spmd,CHEBI:57834,orndc
ReactionID=3-DEHYDROQUINATE-DEHYDRATASE-RXN,4.2.1.10,,,SUC,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,succ,CHEBI:30031,dhqti
ReactionID=GLUTDECARBOX-RXN,4.1.1.15,,,SUC,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,succ,CHEBI:30031,asp1dc
ReactionID=ASPCARBTRANS-RXN,2.1.3.2,,,SUC,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,succ,CHEBI:30031,aspct
ReactionID=ISOCIT-CLEAV-RXN,4.1.3.1,,,SUC,,UNCOMPETITIVE,-,,Escherichia Coli,EcoCyc,succ,CHEBI:30031,icl
ReactionID=PEPDEPHOS-RXN,2.7.1.40,,,SUC-COA,,,-,,Escherichia Coli,EcoCyc,succoa,CHEBI:57292,pyk
ReactionID=THIOSULFATE-SULFURTRANSFERASE-RXN,2.8.1.1,C00059,,SULFATE,,,-,Sulfate,Escherichia Coli,EcoCyc,so4,CHEBI:16189,cyanst
ReactionID=F16BDEPHOS-RXN,3.1.3.11,C00059,,SULFATE,,,+,Sulfate,Escherichia Coli,EcoCyc,so4,CHEBI:16189,fbp
ReactionID=D-PPENTOMUT-RXN,5.4.2.7,C00059,,SULFATE,,,-,Sulfate,Escherichia Coli,EcoCyc,so4,CHEBI:16189,ppm2
ReactionID=2TRANSKETO-RXN,2.2.1.1,C00704,,SUPER-OXIDE,,IRREVERSIBLE,-,O2.-,Escherichia Coli,EcoCyc,o2s,CHEBI:18421,tkt1
ReactionID=FUMHYDR-RXN,4.2.1.2,C00704,,SUPER-OXIDE,,,-,O2.-,Escherichia Coli,EcoCyc,o2s,CHEBI:18421,fum
ReactionID=GLUCARDEHYDRA-RXN,4.2.1.40,C00898,,TARTRATE,,,-,"(R,R)-Tartaric acid",Escherichia Coli,EcoCyc,tartr__l,CHEBI:30924,glcrd
ReactionID=RXN0-703,1.1.1.130,C00898,,TARTRATE,,COMPETITIVE,-,"(R,R)-Tartaric acid",Escherichia Coli,EcoCyc,tartr__l,CHEBI:30924,dogulnr
ReactionID=HOMOCYSMETB12-RXN,2.1.1.13,,,THF,,OTHER,-,,Escherichia Coli,EcoCyc,thf,CHEBI:57453,mets
ReactionID=3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN,2.1.2.11,,,THF,,,-,,Escherichia Coli,EcoCyc,thf,CHEBI:57453,mohmt
ReactionID=RXN0-5073,3.6.1,,,THIAMINE-PYROPHOSPHATE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,thmpp,CHEBI:58937,ntp12
ReactionID=HOMOSERKIN-RXN,2.7.1.39,,,THR,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,thr__l,CHEBI:57926,hsk
ReactionID=ASPARTATEKIN-RXN,2.7.2.4,,0.167,THR,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,thr__l,CHEBI:57926,aspk
ReactionID=HOMOSERDEHYDROG-RXN,1.1.1.3,,,THR,,,-,,Escherichia Coli,EcoCyc,thr__l,CHEBI:57926,hsdy
ReactionID=GUANOSINEKIN-RXN,2.7.1.73,,,TMP,,,+,,Escherichia Coli,EcoCyc,dtmp,CHEBI:63528,gsnk
ReactionID=DAHPSYN-RXN,2.5.1.54,,,TRP,,,-,,Escherichia Coli,EcoCyc,trp__l,CHEBI:57912,ddpa
ReactionID=ANTHRANSYN-RXN,4.1.3.27,,,TRP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,trp__l,CHEBI:57912,ans
ReactionID=ANTHRANSYN-RXN,4.1.3.27,,,TRP,,NONCOMPETITIVE,-,,Escherichia Coli,EcoCyc,trp__l,CHEBI:57912,ans
ReactionID=GLUTAMINESYN-RXN,6.3.1.2,,,TRP,,,-,,Escherichia Coli,EcoCyc,trp__l,CHEBI:57912,glns
ReactionID=RXN0-3741,3.1.3.89,,,TTP,,,-,,Escherichia Coli,EcoCyc,dttp,CHEBI:37568,ntd1
ReactionID=DCTP-DEAM-RXN,3.5.4.13,,,TTP,,,-,,Escherichia Coli,EcoCyc,dttp,CHEBI:37568,dctpd
ReactionID=H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN,3.6.1.67,,,TTP,,,-,,Escherichia Coli,EcoCyc,dttp,CHEBI:37568,dntppa
ReactionID=GTP-CYCLOHYDRO-I-RXN,3.5.4.16,,0.0016,TTP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,dttp,CHEBI:37568,gtpci
ReactionID=FUMHYDR-RXN,4.2.1.2,,2.3,TUNGSTATE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,tungs,CHEBI:46502,fum
ReactionID=BRANCHED-CHAINAMINOTRANSFERLEU-RXN,2.6.1.6,,,TYR,,,-,,Escherichia Coli,EcoCyc,tyr__l,CHEBI:58315,valta
ReactionID=DAHPSYN-RXN,2.5.1.54,,,TYR,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,tyr__l,CHEBI:58315,ddpa
ReactionID=CHORISMATEMUT-RXN,5.4.99.5,,,TYR,,,-,,Escherichia Coli,EcoCyc,tyr__l,CHEBI:58315,chorm
ReactionID=UDP-NACMURALGLDAPLIG-RXN,6.3.2.13,,,UDP,,,-,,Escherichia Coli,EcoCyc,udp,CHEBI:58223,uaagds
ReactionID=UDP-NACMURALA-GLU-LIG-RXN,6.3.2.9,,,UDP-AA-GLUTAMATE,,,-,,Escherichia Coli,EcoCyc,uamag,CHEBI:83900,uamags
ReactionID=UDP-NACMURALGLDAPLIG-RXN,6.3.2.13,,,UDP-AAGM-DIAMINOHEPTANEDIOATE,,,-,,Escherichia Coli,EcoCyc,ugmd,CHEBI:83905,uaagds
ReactionID=UDPGLCNACEPIM-RXN,5.1.3.14,,,UDP-N-ACETYL-D-GLUCOSAMINE,,,+,,Escherichia Coli,EcoCyc,uacgam,CHEBI:57705,uag2e
ReactionID=UDP-NACMURALGLDAPLIG-RXN,6.3.2.13,,,UDP-N-ACETYL-D-GLUCOSAMINE,,,-,,Escherichia Coli,EcoCyc,uacgam,CHEBI:57705,uaagds
ReactionID=UDPNACETYLGLUCOSAMENOLPYRTRANS-RXN,2.5.1.7,,,UDP-N-ACETYLMURAMATE,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,uamr,CHEBI:70757,uagcvt
ReactionID=2.3.1.157-RXN,2.3.1.157,,,UDP-N-ACETYLMURAMATE,,,-,,Escherichia Coli,EcoCyc,uamr,CHEBI:70757,g1pact
ReactionID=UDP-NACMURALGLDAPLIG-RXN,6.3.2.13,,,UDP-N-ACETYLMURAMATE,,,-,,Escherichia Coli,EcoCyc,uamr,CHEBI:70757,uaagds
ReactionID=UDPGLUCEPIM-RXN,5.1.3.2,,,UMP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,ump,CHEBI:57865,udpg4e
ReactionID=CARBPSYN-RXN,6.3.5.5,,,UMP,,ALLOSTERIC,-,,Escherichia Coli,EcoCyc,ump,CHEBI:57865,cbps
ReactionID=GUANOSINEKIN-RXN,2.7.1.73,,,UMP,,,+,,Escherichia Coli,EcoCyc,ump,CHEBI:57865,gsnk
ReactionID=CYTIDINEKIN-RXN,2.7.1,,,UTP,,,-,,Escherichia Coli,EcoCyc,utp,CHEBI:46398,dxylk
ReactionID=URKI-RXN,2.7.1.48,,,UTP,,,-,,Escherichia Coli,EcoCyc,utp,CHEBI:46398,cytdk2
ReactionID=GTP-CYCLOHYDRO-I-RXN,3.5.4.16,,0.0029,UTP,,COMPETITIVE,-,,Escherichia Coli,EcoCyc,utp,CHEBI:46398,gtpci
ReactionID=THI-P-SYN-RXN,2.5.1.3,,,UTP,,,-,,Escherichia Coli,EcoCyc,utp,CHEBI:46398,tmppp
ReactionID=ACETOLACTSYN-RXN,2.2.1.6,,,VAL,,,-,,Escherichia Coli,EcoCyc,val__l,CHEBI:57762,achbs
ReactionID=ACETOOHBUTSYN-RXN,2.2.1.6,,,VAL,,,-,,Escherichia Coli,EcoCyc,val__l,CHEBI:57762,achbs
ReactionID=3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN,2.1.2.11,,,VAL,,,-,,Escherichia Coli,EcoCyc,val__l,CHEBI:57762,mohmt
ReactionID=PRPPAMIDOTRANS-RXN,2.4.2.14,,,XANTHOSINE-5-PHOSPHATE,,,-,,Escherichia Coli,EcoCyc,xmp,CHEBI:57464,gluprt
ReactionID=GTP-CYCLOHYDRO-II-RXN,3.5.4.25,,,XTP,,,-,,Escherichia Coli,EcoCyc,xtp,CHEBI:61314,gtpcii2
ReactionID=BADH-RXN,1.2.1.8,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,betaldhx
ReactionID=IMIDPHOSDEHYD-RXN,4.2.1.19,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,igpdh
ReactionID=INOSINEKIN-RXN,2.7.1.73,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,gsnk
ReactionID=GUANOSINEKIN-RXN,2.7.1.73,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,gsnk
ReactionID=DARAB5PISOM-RXN,5.3.1.13,C00038,,ZN+2,,OTHER,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,a5piso
ReactionID=SAMDECARB-RXN,4.1.1.50,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,admdc
ReactionID=MALIC-NADP-RXN,1.1.1.40,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,me2
ReactionID=FUMHYDR-RXN,4.2.1.2,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,fum
ReactionID=NADH-DEHYDROG-A-RXN,1.6.5.3,C00038,,ZN+2,,MIXED,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,nadh16pp
ReactionID=RXN0-1483,1.16.3.1,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,feropp
ReactionID=RXN0-5209,2.7.7,C00038,,ZN+2,,,+,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,ap4as
ReactionID=RXN0-5208,2.7.7,C00038,,ZN+2,,,+,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,ap4as
ReactionID=DARAB5PISOM-RXN,5.3.1.13,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,a5piso
ReactionID=ALPHAGALACTOSID-RXN,3.2.1.22,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,gals3
ReactionID=CYCPHOSDIESTER-RXN,3.1.4.16,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,23pde2pp
ReactionID=RXN0-299,1.14.11.17,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,taudo
ReactionID=2.7.9.3-RXN,2.7.9.3,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,selnps
ReactionID=3.4.13.18-RXN,3.4.13.18,C00038,,ZN+2,,,+,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,amptasecg
ReactionID=N-ACETYLTRANSFER-RXN,2.3.1.1,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,acgs
ReactionID=ORNCARBAMTRANSFER-RXN,2.1.3.3,C00038,,ZN+2,,COMPETITIVE,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,ocbt
ReactionID=HYPOXANPRIBOSYLTRAN-RXN,2.4.2.8,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,adpt
ReactionID=GLUTDECARBOX-RXN,4.1.1.15,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,asp1dc
ReactionID=TETHYDPICSUCC-RXN,2.3.1.117,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,thdps
ReactionID=PHENYLALANINE--TRNA-LIGASE-RXN,6.1.1.20,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,phetrs
ReactionID=UDPACYLGLCNACDEACETYL-RXN,3.5.1.108,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,uhgada
ReactionID=LYSINE--TRNA-LIGASE-RXN,6.1.1.6,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,lystrs
ReactionID=ARGSUCCINLYA-RXN,4.3.2.1,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,argsl
ReactionID=GALACTUROISOM-RXN,5.3.1.12,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,gui1
ReactionID=GLUCUROISOM-RXN,5.3.1.12,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,gui1
ReactionID=CYTDEAM-RXN,3.5.4.1,C00038,0.0058,ZN+2,,COMPETITIVE,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,csnd
ReactionID=ACETYLORNDEACET-RXN,3.5.1.16,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,acoda
ReactionID=MANNONOXIDOREDUCT-RXN,1.1.1.57,C00038,,ZN+2,,,+,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,manao
ReactionID=ADENYLOSUCCINATE-SYNTHASE-RXN,6.3.4.4,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,adss
ReactionID=N-ACETYLGLUTPREDUCT-RXN,1.2.1.38,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,agpr
ReactionID=GLYCOPHOSPHORYL-RXN,2.4.1.1,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,glcp2
ReactionID=KDO-8PSYNTH-RXN,2.5.1.55,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,kdops
ReactionID=3-NUCLEOTID-RXN,3.1.3.6,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,3ntd2pp
ReactionID=D-PPENTOMUT-RXN,5.4.2.7,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,ppm2
ReactionID=GLYCOLALD-DEHYDROG-RXN,1.2.1.21,C00038,,ZN+2,,,-,Zinc cation,Escherichia Coli,EcoCyc,zn2,CHEBI:29105,gcaldd
KI value chosen as center of range 0.1-0.5,2.7.1.11,C00074,0.35,,10.1006/jtbi.1996.0013,,-,,Escherichia coli,Manual,pep,CHEBI:44897,pfk
approximated visually from Fig 17,2.7.1.11,C00074,0.3,,4229913,,-,,Escherichia coli,Manual,pep,CHEBI:44897,pfk
,2.7.9.2,C00026,1.27,,4572511,,-,,Escherichia coli,Manual,akg,CHEBI:16810,pps