Supplemental methods. Table S1. Blood culture results at 24 hours. Table S2. Demographics of participants in neutrophil experiments (females with CF). Fig. S1. Survival in males versus females when age matched. Fig. S2. Estrogen and progesterone treatments in mice are physiologic. Fig. S3. Survival in ovariectomized female mice infected with mucoid P. aeruginosa, M57-15. Fig. S4. P. aeruginosa growth is insensitive to E2 or P4 stimulation. Fig. S5. Estrogen induces inflammation in the setting of P. aeruginosa infection. Fig. S6. 17β-Estradiol impacts responses to P. aeruginosa infection of neutrophils from female subjects without CF.
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