Region-specific protein misfolding cyclic amplification reproduces brain tropism of prion strains

Supplemental Data

• Supplemental Figure S1 (.docx, 293 KB) - Glycosylation pattern of PrPres in C57BL6 infected brains and in PMCA amplification products.
• Supplemental Figure S2 (.docx, 309 KB) - rsPMCA modeling of region-specific targeting observed using different vCJD patients as seeds and different MM patients as substrates.