>IKKA_HUMAN
MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSG
GDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENKPYTA
TVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRC
FVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGISLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFAS
RSLSDCVNYIVQDSKIQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKLEFFHKSIQLDLERYSEQMTY
GISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAEIMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRV
LKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQSSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTP
QDGETSAQMIEENLNCLGHLSTIIHEANEEQGNSMMNLDWSWLTE

>IKKB_HUMAN
MSWSPSLTTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCLEIQIMRRLTHPNVVAARDVPEGMQNLAPNDLPLLAMEYCQ
GGDLRKYLNQFENCCGLREGAILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCTSFVGTLQYLAPELLEQQKYT
VTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSEVDIVVSEDLNGTVKFSSSLPYPNNLNSVLAERLEKWLQLMLMWHPRQRGTDPTYGPNGCF
KALDDILNLKLVHILNMVTGTIHTYPVTEDESLQSLKARIQQDTGIPEEDQELLQEAGLALIPDKPATQCISDGKLNEGHTLDMDLVFLFDNSKITYETQ
ISPRPQPESVSCILQEPKRNLAFFQLRKVWGQVWHSIQTLKEDCNRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLKAKLDFFKTSIQIDLEKYSEQ
TEFGITSDKLLLAWREMEQAVELCGRENEVKLLVERMMALQTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTEGDSQEMVRLLLQAIQS
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMNEDEKTVVRLQEKRQKELWNLLKIACSKVRGPVSGSPDSMNASRLSQPGQLMSQPSTASNSLPE
PAKKSEELVAEAHNLCTLLENAIQDTVREQDQSFTALDWSWLQTEEEEHSCLEQAS

>TBK1_HUMAN
MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEE
PSNAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGAARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGA
TVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLLTPVLANILEADQEKCWGFDQFFA
ETSDILHRMVIHVFSLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLNTIGLIYEKISLP
KVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKINLEAAELGEISD
IHTKLLRLSSSQGTIETSLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMTEIYYQFKKDKAERRLAYNEEQIHKFDKQKLYYHATKAMTH
FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDIEEEVSKYQEYTNELQETLPQKMFTASSGIKHTMTPIYPSSNTLVEMTLGMKKLKEEMEGV
VKELAENNHILERFGSLTMDGGLRNVDCL

>IKKE_HUMAN
MQSTANYLWHTDDLLGQGATASVYKARNKKSGELVAVKVFNTTSYLRPREVQVREFEVLRKLNHQNIVKLFAVEETGGSRQKVLVMEYCSSGSLLSVLES
PENAFGLPEDEFLVVLRCVVAGMNHLRENGIVHRDIKPGNIMRLVGEEGQSIYKLTDFGAARELDDDEKFVSVYGTEEYLHPDMYERAVLRKPQQKAFGV
TVDLWSIGVTLYHAATGSLPFIPFGGPRRNKEIMYRITTEKPAGAIAGAQRRENGPLEWSYTLPITCQLSLGLQSQLVPILANILEVEQAKCWGFDQFFA
ETSDILQRVVVHVFSLSQAVLHHIYIHAHNTIAIFQEAVHKQTSVAPRHQEYLFEGHLCVLEPSVSAQHIAHTTASSPLTLFSTAIPKGLAFRDPALDVP
KFVPKVDLQADYNTAKGVLGAGYQALRLARALLDGQELMFRGLHWVMEVLQATCRRTLEVARTSLLYLSSSLGTERFSSVAGTPEIQELKAAAELRSRLR
TLAEVLSRCSQNITETQESLSSLNRELVKSRDQVHEDRSIQQIQCCLDKMNFIYKQFKKSRMRPGLGYNEEQIHKLDKVNFSHLAKRLLQVFQEECVQKY
QASLVTHGKRMRVVHETRNHLRLVGCSVAACNTEAQGVQESLSKLLEELSHQLLQDRAKGAQASPPPIAPYPSPTRKDLLLHMQELCEGMKLLASDLLDN
NRIIERLNRVPAPPDV

>TBK/E_Ciona
MNPHPAHNSSPIRSTLNYVWSTTEILGQGATGFVFKGREKKTGQEYAIKVFNSLNYMARSLEARRREFEVLRKVDHKNVVRLFSVEEELTTKHDVIIMEL
CPNGSLYSMLDDPENLYGLPESEFHRVLSHITAGMKHLHDKGIVHRDLKPGNIMRSLDDDGTAVYKLTDFGAARELGDDEQFMSLYGTEEYLHPDIYERA
VLRKHAGKMFSATVDLWSLGVTLYHVATGMLPFRPYGGARRNKDVMYRITTEKPSGVISGVQHSERGSIEWSRELPKTCRLSHGFKKIFTVVLSGILECN
PHKIWTFDRYFAEVEDILSKKVINVFSVPNAMLHKVYISPEKTLVSFQEAVAELTEVRSSKQLLLFDGEQFEMEQFVAVKSYPHTTPEHPLILFSSDIND
FQAITIPHTCKPPKVKPSLSLDNDSSLAKVCSSTLFDIRKSVSYLLLVQILIRLSVKWFVCYLKSRVVKLKLLRSNLQCKVDCLRTALEIFEEHYQRETS
LLTVITNLVTSPPEVNELKLYFTQITEKAKILRQIRTEFDQLNESTNQFDKLIIQEEIPSSIFVDEGSQTNDRLEERMKVASEKSREISRLFKTHKKIRR
LSHSDDQLHKFEKQRLAEVCEASVTLFTDKSVPGCKRLHKESINWFSNMNEYQKKLWNCETRIMRLSDRCQEQEESIRTLQRVYRDKLSLVESILKENAK
PLSAASLPGPNLNVVQPSIAVPSSWPNSIDNPRSSRQRQLKQLRQGLIEAKNSLNEVRCEVQTGSEILKKLSSLTANRNCASPETPSRPCVPMRTND

>IKKAB_Ciona
MLATRPPQRQPMQCGEWTLIKILGSGGFGQVSLWKNKQDVKLAVKQCKNQLSRQNERRWRKEVEMMQRLNHPSIVNFVEVPVEIQNAYVDHYVALGMEYC
EAGDLRKFLTQPENCCGLPEFQVRNILQDIGSAIEHLHERQLVHRDLKPENIVMKEKEKNVFQFKIIDLGYAKEINENSFGTSFVGTMHYLAPEFYGANP
LCYTATVDFWSFGLLVYECITGRRPFYPSLELAQVLNDLKEKKRYEHICTVETQGSTHVYSSTIPQPHSLNPIFAKKIESWLQQMLQLDPQLRGGGVGNN
EWFKTVERILREKCIHVYNTQNNSVFTIPVLDERMSIAKMQEAIMRATNIPIPSQILLLKDGKKPDVRYSAVNECWKKPDHHEWLIFLFSCTGTYQRYQC
ALPKEIGTLIIEPRTPLRNPPQRRVLSIATNCVRREALVCRRSIAALATLSESIERHTNYYEQQLKSFSDAFNMFRGKVDFFKFSIEKDLSNCIETDICD
NNELLNQRQGSWYDQLNLVNRHREQTCPTIHNMLQNCAEPYRIREHIKISKEIVAVTTKKCDDWENEAKKKYSLIKNEIRKIEADIRTNHETDVNALQHT
MRDLVMNFIPKTLEELTTQLAKIMQCTKILVEWHEWINEKLPQIGSSLQNLGIQSKDLMDHQARRQTEIFESMSQIQTEVRLDNETVQQQIQDAEEQVGR
ESEGRQQTQQEMGNHVSRLKEMIEGVTSDDVIKQLKDLNDVFSSICEGNNTTENNIVSHFLPTVTTLPNVSPTPIEQNSEPSFNHQDITHDLRNLNLNNN
NDTDNRNTDINGSSVEVS

>IKKAB_Drosophila
MITVVFCFSDCHGGIQILGRMSSVNKIKLNENNKMHSFGNWERCRNLGEGGFGLVIHWRNRTTGREIATKHIKEMGALSADQQVKLSERWNKELNWSRQF
KNFPHIVAGVDIEDPDFLEYLNGMFSAKLPVIVLEYCNGGDVRKRLQSPENANGLTEFEVRQILGALRKALHFLHSQCGICHRDLKPDNIVIQRGVDGKK
IYKLTDFGLARGTPDQTMVQSVVGTRHYYAPEVVENGFYNSTVDLWSFGVIAYELVTGELPFIPHQTLKNIILNLIKKPAKCIAITEDPEDNTRFVNQFE
LPQTHHLSRPWAAQFTKWLASPLNSNYKERGQLAANNVPVVFADLDKILNMNVLTIFAVNNCERLEYAVSAEMTMKDLIALIVLDTGMDEKELYFVLPTS
HPHKTITPKSTPLQLYVEEWSDTSKDSRKWTKRSNPPVMLYIFQVKKECDYKIPEPILSILSRKFIANKFKTKERWLQKRVVLDMLYVLTKEQARYEMLV
SGINERALSLEDEMMENSFIDSIDKQRIIISFAYDQLTSLLKEAQAKIPSRQLISSAQWEKLNRNYNFIIQSAKSIRSFLEACLREAKDMVKTTNQLRKE
VCEKDLFDCARFYKKYLCNGAIISPSELNNDAEEFAKSRFKLYNEGEARHLPKSIDHMHYLYFKTKESIPVLLQQFCDIKKEIFQINLQMLMSASSTPPP
KLELSAAMDRLAISSGSPSSDPFDSLRTINAIEEAERINNILVNEMKIDHY

>TBK/E_Drosophila
MSFLRGSVSYVWCTTSVLGKGATGSVFQGVNKITGESVAVKTFNPYSHMRPADVQMREFEALKKVNHENIVKLLAIEEDQEGRGKVIVMELCTGGSLFNI
LDDPENSYGLPEHEFLLVLEHLCAGMKHLRDNKLVHRDLKPGNIMKFISEDGQTIYKLTDFGAARELEDNQPFASLYGTEEYLHPDLYERAVLRKSIQRS
FTANVDLWSIGVTLYHVATGNLPFRPFGGRKNRETMHQITTKKASGVISGTQLSENGPIEWSTTLPPHAHLSQGLKTLVTPLLAGLLEENREKTWSFDRF
FHEVTLILRKRVIHVFFTNRTSSVEVFLEPDEQIDNFRERIFLQTEVPLEKQILLFNNEHLEKKVTPRTIAKAFPATTTDQPIFLYSNDDNNVQLPQQLD
LPKFPVFPPNVSVENDASLAKSACSVGHECKRRVDIFTSMDILIKKGVEHFIEMLVTTITLLLKKTESFDNLLSTVIDYADVVHSMARVTKGDQEIKTLL
TALENVKSDFDGAADVISQMHKHFVIDDELNDQWTSSMHGKKCPCKTRASAQAKYLVERLRDSWQHLLRDRATRTLTYNDEQFHALEKIKVDHNGKRIKA
LLLDNVNPTVAQIAECLADWYKLAQTVYLKTQILEKDVRDCERKLNGIRDELYHVKSELKLDVDTKTINNNNQLAKIEERNRLRVMQQQQQEVMAVMRTN
SDIISLLSKLGITNGSLESS

>TBK/E_Nematostella
METRSSSNYIWNLKSVLGQGATGAVYTGRHKKSGDVVAVKTSNHLGMMRPLEVRKREFDVLSKLDHENIVKIFASETELRSQNEIIVMELCSGGSLFTML
EHPSNAYGLSEQDCITVIRDVVAGMKHLHDNGIVHRDLKPGNIMRVYRDDGSCVYKLTDFGAARELMESDQFVSIYGTEEYLHPDLYERGVLRKATGKTF
GAQVDLWSIGVTFYHIATGRLPFRPFGGRQNKDTMYHITTRKASGMIAGVQKSEGGEVEWTDKLPDHTCLSQGFRNLLTPLLAGVLESDPAKMMSFDQFF
AYVQDMVSRKVLDVYCVSSSQFHKIYIRRTEMLNRFKQMVTEQTSVPCDQQELFYEFQYFQPPDMCPAADFPNTSRDRPVIMIGGEQLAPDKLVNLAIPK
ITELPPEWTLEGDAAVSKIMANCAYSCEHSVAVYSDSVKAMTDMIHTLGNCFRQRMIDHDLVCKEVESQRNAVHNMTEVYCASQENSVKMLTDVMEQVSF
REEERAEADREVVGILELVRMKRKSDDVQSKETAEWLIPLKVTLHDAIANNPLEVEAKAFFRIADTKPLLCTVSTLRARIEEFYNRFRKEKHLRRLSLAD
EQNHVFDRRKLSAECKRVMELTKHSAELRALLHGELTGWLSRAKTLEARVCQRMGQVYEIRNRDQLHVESMEKFQEQSNATCKRVVERVKGAMVRGSTSS
IGTDLPSIVANGDADHGDDHNVSWSELDSHIATLVKVTESSKASAMENSQYIQRLTSSLNEFFHVINESDRQSIEELQKLSMIETQ

>IKKAB_Nematostella
MESNKLRQSSQDGWVEERCVGTGSFGTVTLWENKITKEQIVLKKCRLDLSPSNRNQWQKEVEIMKGLDHPNIVKAIDVPAVLDVREGQLPLLGMEYCEGG
DLRKVLNSPDNCAGLKEASVLRVITDIANAVQFLHSKRIIHRDLKPENIVINFTNGNAVYKLIDLGYAKQLDQGSMASTFVGTLKYLAPELLAGNGSYSK
TVDYWSLGTVVFECITGRRPFPDLSPVQWYMEIREKSARDIHAYFDAAGELKFSELLPTPNSLTSFYQERYVFLLRLLLLWDAKERGGRQREDGVQDCFH
VIQELANAKVVHVYCVANSVIFSYEVVAEETVGSLKQKLQNDTEIPIDSQELLTASGEIQLDDAPTSKLLGKTSNGEQRLMFLFMRNGKPQSPYRPIFSL
SPSVQAIVTEPKTLLLFEELKKAQGEALHFCQDQKENFQHLLQAHRAAMKHALKLNAHLTKLRSSLQNDLLRLRERVAFFKESLSTDLQHYSDEALHLKS
DGVFRSWKEAERTVESFSTVDISTIENDVTKLQGHVMELQRHSYAHAQIAMDDIYQDAVKVYQSLKQKIANSTVYDQRVGHCSEMAPVVRRCLVTREKLL
RDVNTHISCIFQVTQNLQTLVPQLEEKREEINYRHLEIAKLQRKRQEDVWSLRSQAMEDEITLSDLHTSGEDTEHVIDQSYHAMNSFAQAITSVKEEQNT
ITQSLDWSFLEDDDHTNS

>IKKAB_Aiptasia
MQVSGHDDWIEERCLGAGGFGTVTLWKHKYNHEYLAIKKCRLDLSPANRQRWHQEVEILKKLDHANIVKAKDVPAILDVSGGEIPLLAMEYCEGGDLRRI
LNTPENIRGLKESTVIEVTADVAHAIEFLHSKRIIHRDLKPENIVIQHTDGKDIYKLIDLGYAKQLDQYSIATTFVGTLRYLAPELLAGNGSYTKTVDYW
SLGTVLFECITGIRPFPDLSPVNWHREIGQKSPRHIHAFYNASDEMTFSEVFPELNTLSRCFQEKYVNLLRLLLLWDPVKRGGQVHEDGSRQCYKLLHKI
LDSKVVHIFCAFTSTLLTFEVTQTDRREDINARIYEETGIALDDQVIVSPAGQEIGADSPMLEYIHKNNGTPSTLYLFSKSSIPASPRPLFTLPSTLQSV
VTESKTLLPYLEQKRIHAEALSFCYKQMKNYKYLIQAHLTLLKYTLKLHSRLSQLRTNLTSDCIRLEERITFCRESLHTDIEHFSDVAVDLHANDMILRS
WREGERNWINFDKSGVMEAEKLAISAQTQVLELQKIPFNQSQPVSNPMEEIYNSAVIVYDDFKRANLTSYDQKMADCSKIAEVVLKCLTKREKLNKEMFT
HLRRILQCSTELQNVVPKVIEKTRQISHHKDHILQIQKQRQEDVWCLISNKQDSVDSGVNYPTLDLTLSSYKMDSSELTKQSLQNIERLSEVVQSVKVEY
GNVAPESLDWSFLEEDTEV

>TBK/E_Aiptasia
MEIRSSPNFMWHIKDVLGQGATGAVYKGRDKKTGNEVAIKVTNHLGMMRPLDVRKREFEVLNRLDHENIVRIFASENELRSQNEIIAMELCSGGSLYTLL
EHPSNSYGFSEKDCKDIIRDVVAGMEHLRKQGIVHRDLKPGNIMRVFNDDGTCSYKLTDFGAARELEHSAEQFMSVYGTEEYLHPDLYERGVLRKSSGKT
FGANVDLWSIGVTFYHIATGKLPFRPQGGRQNKDTMYHITTAKASGMIAGVQRISDGVIEWSDKLPDHTNLSRGFQDLLVPILAGVLESDPSKMMSFGEF
FRRVQDMVTRKVVSVYHVQTSSFHEIYIPPTAQFEAFQELISKETGLPPAHQKLFVNGEVFKRSHATDTAEKFPSTSRENPMILVGGEFVLPEDLTPRKI
PIVTKLQKDYTLESDAAAAKIRANCAHACKVSTLFYTQVVNVMCISLNTIVKSLKNDLLKALADCGKVEGRRTTASHMTAVCCNSQVHFMTLLERLMSHI
KLSDGEKSSIEDEFTMIKHSIQNKRQSNQELDKVKDFIEKIKVLQCDFVENDTYASSLSTFCKQARGKSLFPLVSSLTSKIEDIYSRYRKDKHLRRLPYA
EEQNHNFDRKRLGQLTDKVTDATNQMFDHRVKTYHNFIDLYKEVDLYQTEACRLKDQLLRIAPADEAHVVTLEAFQNECQEKYQSILTRLCEAMKTVAVP
SSSSVGTDLPSLGLPSNGISEEAMSEQMLQEMERHMKTLYDATEFSNKTAKENGSQLKELTDSFTEFYKLLAESGTRTLNDLKVLQEVSAPLSPVSPE

>TBK/E_Amphimedon
MAYNYQQVRPAFIGGGDETEYYSLSYIWSSKDKLGQGATGQVFAGYSKRSGDKVAIKMFTSPSEYKAMQSEMQTIKALKTHPNIVSFFELNEIEKKHQYH
IIAMELCNGGSLYEVIDSPQNAYGLDEYQFKSVIFDVASGMRHLRDHGFVHRDIKPGNIMRCINPDGSFVFKLADFGTARQLDPNEHFTSLHGTEEYLYP
AMYERALINYRSKEEFLDKVDLWSLGATFFHLATGRLPFRPYRKRQDRGTMFKIINEKKTGIILGWQQEYNAPIYYSDRLPPDIVISQGLRDIITPILAG
VLDTFDSMWAFDRFFKAIDGIKKQNVVHIFCVSRCTCHMIYVDDAGEADIIPKFKELIARQTSLDPKHMEMYLENILFGTEPVRARDLPLTTPDSPLTVF
GGPPQKPDKLATPVVTQPPNMPPETTMVDDLRYAKDCTKAIWVMYRAAETMDRYFRLMNQGALCLRETLDKDYRAWCRKYEEVQVRFNSLIDITFDHDIA
DLQRQLEDKNKHLVDVRDQSFALHEQTKDFHSTVNSITSSSIWDTNYLAKVFNESTKTMMSYVDKVEEIFNAFQEQKKQRGAIHGDYDRRSHEYNKRTIK
ERLGMADKKLSEMIAGRNHVYGNLYHFLEKCTPVREDLRNLMASLDHSAQCTKEDTIRLQKWLPHHQQRMQNLLGKLPNSLSGGGGGGGGMGTLQLNSLR
SLLQRARESTGDLLKLADKQKTLIHPPSDKKEKS

>IKKAB_Hydra
MRDWMKNTDLNSIRELIISLHKKNLSQADIWRRLNDIKVSKSLISRTISRYKTTGQTIPAKTRKRKRVKRTPAIIKVVRERLQRNPARSGRQLAKELNMS
YTSMQKVIKQDLRLKCYRKQKTAGLTDKNKVERVKRCKSLLKRHGGADIVFSDEKMFTLERPLNRQNDRVYAVKLSDVPLNVRTVPRYQNASVVMVIGAI
SKKGKFPLKFIDRGVKIKKEYYLQNVIKDLIEPKAKEMYGDDPWVFQQDSAPAHKAIVVQDYCKQNFPDFIDIKEWPALSPDLNPLDSFVWGYMLQELGK
HKLTTLDQFKELLIDIWDKMPQETFDMENGKVYGNWKYEKQIGCGAFAKVSRWKNIKTDKELVVKQCNSVLSVQSRRRWNDEIKLLKRLERHKNLVEERD
VPEEIIKALASPENLLGLESCECDLREVLSYTENCCGLIESMVLRVLEDVACGLNFLHEKNIIHRDLKPENILKGHKGDQVVYKIADFGFAKDLDRSMCK
TVLGTQNYMAPELYESQSGYTKAADYWSFGTVIFECITGIRPFDLIKENKLKVICNKSDTEIWGCETPDGVKFYSDIPMPNRLCKSLTSSLKKWLQLVLC
HDADKRGTTECFSMIKDILSINEIHLFDIMTCQETSYACKPGDTVQNLKLFIKQEFGIEAYDQYLVKLGSDFLSDQQCLENYVQRTEVVFVFRDNIDATY
KINKDMPDRVKELLGHYEEIQKYHELLLKWSHCIYYCTKQSNNYDRLLEGKNALIKILKCRMETIDELKNELTELIIQNETGIHFFNKSLETDIQLYGTD
VPQDEWLKAQTEITKSNDDASNLKSLLNDIFNLKSDVEKISVVNGNQFSNELKKIKERAESELYNLSKQKSNKVESNSATMFNIVLEMHSNEKPFIEFYF
QLKQVMKTKEKMRNINAALLKKKCALIKFKNSILETQLCRQAKLRESVTPCVFEEATFSIGYNPLSTFNSETLFAVKELKAGGTYNLRKLPKFAIDLIRY
DTGSSVRAALGNAPMIDLFDDIAITKTLVIDRFKIDSQKKIVKVLSDLKSIKDNTELICFDKDEPFEGFTDEEIV

>TBK/Epar_Hydra
MNVVRQSLNYVWSVQEVIGNGATGTVYKCLAKKTGAPCAAKVFNSQADRRPYEVRIREIELLKKLSHPNIIKLMGLEQEIGSKATVLIMELCGSSLYEII
EEPENMFGVDDITLINIIQDVCAGMEYLKNSNVVHRDVKPGNILRADKGSGGYIYKITDFGAARELGEAEQFVSLYGTEEYLHPDIYEKAVMKWSSNKTF
TSRVDMWSLGVTFYHLATGQLPFRPAGGRQNKDIMFKMISEKSNDAISCYQDLDNGSLIYSNELPKKTRISENLKMHLTPILKCLLQIQQQFMLSYDDFF
KEIKELVSLKVRNFLILDSSFFSHFNSWHIVMGSQYCEEQEK

>IKKAB_Trichoplax
MAKLSHKNLVRTVHAPDDLLAKLQNYGHSITMEYCNGGDLADHLAATRFGLDEVNIKKFINDISSAIACIHSKRIIHRDIKPENILLMSHNGEHTYKLGD
FGISKFCTGAEPRTVAKTFAGTSPYMAPEVQIRIQEYTKSVDIWSFGVVIYECVTKSLPFSDVSLQEMEKIDYFMEKPVEAIRTFLDSNGKVQFSTELPI
ENNLYAPTIQKITNFLQLLLDGNPKRRGGYNEVTNTYQCFNFNELEIFKDTRLIHIVLANTLEIYSVEDDSEGRLNLDEIRRTSLKSFGLSCDISDYKLV
LHTAVMDARSKRTKNSWITAMDLTMNKEENIITYDQDIRAKLAFLKNFCKRRRLENMNEKDKYHLYAFRLSINRLFLYMDNILSYCKLGIENTGSLCRTV
RKKYQDMQQRMKGILSQITEFNAIYKCYETLFSCDHQWVIECLDEEQKKEWETLTATRTRMKAFEKEMSELEQNMVVIQKEFEIFQSKNLEENISNSMTE
FTNSSNKISINYQDLLKCYPTDVNQRRIDEFVQSWTNWYERIKIIHEKCINYLREVLAIMKVISTALEQLNKTPSELTENTVTVQKKVCCDSSYIQYADL
AINSLLFCTNEVCEVI

>IKK?_Mnemiopsis
DNYEKLAPEEQRLNLAQKIYQQCLCDEYLFVPSLSVCRFCCNQVKRETFGYFYLLAWVVTHVRTEQTDRFHVRTEQTDRYHVRTEQTDRYHVRSEQTDRY
HVRSEQTDRYHVRSEQTDRYHVRTEQTDRYHVRTEQTDRYHVRTEQTDRYHVRTEQVRTEQTSDCSHIVKNFCQVAIGGETTKKAESRLPDHLIDREKVN
EVEDKLLGESPRYIYSEIASTVRDYLSGEPFSSYLESKYFTRQLQWKQLEKKPIGKHTFRHYRVLGKGGFGEVCATQSRASGKMYAEKKLNKKRIKKKKG
EMMALNEKELLEKVNSIFVVSLAYAYETKENLCMVLTLMNGGDLKFHIHSMGAFTEDRARFYTAEILCGIQHLHQCNIVYRDLKPENILLDDAGHVRISD
LGLAIHVPDRQVVKGRVGTVGYMAPEVIKNERYSYSVDWWGLGCIIFEMIEGQAPFRSRKERVKREEVEKRILDGKYTFSDKFSDDSKDIVRQFLELTPA
TRLGVKGDKWTTAKQHKFFDKIDWIFLEAGSATPEFVPDPHAVYAKDVLDIEQFSTVKGIVLDEADEEFYRKFATGSVAIPWQDEIIEVGVFKEINVYYE
NDELVSPKEENSKKSLLDKIPLFRKKKTTPPNSNSES

>IKK?_Pleurobrachia
MIDRVSTDEDCSRETEILLSHLRLKRKIGYGGFGYVYEGTYRGTKVAVKKMHSNRRNRMLVLESLRAELFVVRMNLSHPNIVRTLGTTSSGPEVDDLPFL
VMEFAGRRNLQCVINNTEEEIISPCRRTKYAAQVCRALEYTHSKGIVHLDVKPANVIVDDSDTCKLGDFGCAQRLGDSGNEFTASPSITGTTVYRAPELL
RGFCPQTSADIYSVGVLCWTLLTREVPYGAENLQVITWGVVMLNLRPDSHNLAREDQGEAEYQELYKDCWEAEPTSRPTASEFLERLQNIAP

>IKK?_Capsaspora
MSANTRTLRSSQRPTPGAGDEEEGSSTQFLGKFKLLRTLGHGSYGKVKLAQHIETGQKVALKILEKSNIKSNKALKRIFREIGYLKVLHHPHIVALLEVI
ETTDRIILIMEFAAGGELFDYIVARQNLKEVEARRVFRQIISAVSYCHQSALIHRDLKPENLLLDSDLNIKIIDFGFSNVYRTDMVLNTFCGSPYYAAPE
MIVGQSYVGPEIDIWSMGVILYTLLCGHLPFDDDNLTRLYEKVLVGQFDLPETLSQMAKDLLVRMIRVEPGGRAPLEEIAKHPWVMEGYDTPVNAYLPPR
LEIDEVDEVIFRQLLKYDFDAIEADEDLHRPGVNPAKGMYYLLCEKRDRDLKKFAAAAAANNAAALSASQSVAHMRSGSNTAMPMNVVPASAEEVAAAKA
AATAQQSAQQSRLAQLREQRYSKLASDTRRSRTIASVPARAPESAGVVGQMMPSDIDPMQAMVNARQAHLQASGGSSSGGVITVTAPIAVAPSLGPSIGE
RVQSVNHNISGGALPSSPLPIEPLGDLSAPVKPVQQQPSATTAAAAAAAATATTAAPVAAAAPAAAAPAMTPAERMQMLMANAKAHQAKKASEGAAPQAA
AEPAVAAAAAAAAAVTPAPVAAAPVVASNASETSMDSSKPDSAESTPTSSGASSAVGSPNSSQTQMAPVDEPRKTVVVAGKGSGAVKFALPAGQQPEEDE
PEDELPVPDLPASSTPATAATATASSAGPMTTTAAAAAGGAVPPASSVAKSSAKAAGDAQKKKRFLSLDGAMSSFIAAFGRKKASQPTANGAIGEAGEEG
TAEEPAEDVSGNAQDAGTVDANGVRELPANDLRTLKGFYDVSTTSSKPVPDIITEISRVLGEIQIDYSWNNVTVSCMQHVELVTTVTTAGGTVIQMNKSP
AALAAAQAKATQFEIEICRVPKLNLCGLHFRRVSGDIWAYRKICHRLFNSLQL

>IKK?_Monosiga
MTVRPAAASVLVFSRLVSILQHSRAHHPCLAYSTERSAQTIGEYIMYKTIGKGNFARVKLAKHKLTNVEVAIKVIDKTRLKESHMLKVMREVRILKMLNH
PNIVKLYEVIDTPKYLYLVMEYASGGEVFDYLVSHGRMKEKEARIKFRQIVSALQYCHARGIVHRDLKAENLLLDKDLQIKIADFGFANMYEPDQKLNTF
CGSPPYAAPELFQGREYTGPEVDVWSCGVILFTLISGALPFDGSTLKELRDRVLKGKYRIPFYMSTECERLLRRFLVLTPSKRCNLTQVMTDPWINTGFE
DSPLTPYEHPTPDLRDPERFALLEKLGFNKEEVISSLERDLYDQHTAAYLLLPFASPDTFKQHTKPAQTARPATAAGDQTKSPRASAPNALAGSSASDQV
APTRAMPTAGGSRVDRLKQFQRAGSGGAPPGRGKALPAIPNAPRRHTASSATAVRPTIKSKTVAVPVEQLAATHLSASTAGGPSTHSTSPNKSSALSQSL
RGTRRRRTITEGGEAPSEDGESGVLNRMRRGLRQSFRRASSTGAPKPRALRFTFSMTNTSTKEPEYILQELKRVLALNDVIFENSDDFCLLCEHGDIVFE
MEVCKLPRLLMNGIRHKRISGSSLDYKNICTKVLNETQL