CHEMICAL_ID,UNIPROTKB,TARGET_NAME,group,orthogonal,is_agonist,canonical_smiles,Selectivity_Observations,Total_Observations,standard_inchi,standard_inchi_key,VERIFIED_SELECTIVITY,ENTREZ_GENE,ENTRY_NAME,REACTOME,GO_CC,GO_BP,GO_MF,KEGG,DATA_SOURCE CH5424802,Q9UM73,ALK tyrosine kinase receptor,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,238,ALK,R-HSA-162906 HIV Infection R-HSA-162909 Host Interactions of HIV factors R-HSA-1640170 Cell Cycle R-HSA-1643685 Disease R-HSA-177243 Interactions of Rev with host cellular proteins R-HSA-180746 Nuclear import of Rev protein R-HSA-5663205 Infectious disease R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-73886 Chromosome Maintenance R-HSA-774815 Nucleosome assembly,intracellular IEA GO:0005622 integral component of plasma membrane IDA 9174053 GO:0005887 integral component of plasma membrane TAS 19459784 GO:0005887 protein complex IDA 23382219 GO:0043234 extracellular exosome IDA 19056867 GO:0070062,activation of MAPK activity GO:0000187 TAS 19459784 signal transduction GO:0007165 TAS 19459784 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IEA cell proliferation GO:0008283 TAS 19459784 phosphorylation GO:0016310 IDA 9174053 phosphorylation GO:0016310 TAS 19459784 peptidyl-tyrosine phosphorylation GO:0018108 IEA NIK/NF-kappaB signaling GO:0038061 IEA regulation of apoptotic process GO:0042981 TAS 19459784 protein autophosphorylation GO:0046777 IDA 9174053 protein autophosphorylation GO:0046777 TAS 19459784 neuron development GO:0048666 TAS 19459784 positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS 19459784,19459784 TAS GO:0004704 NF-kappaB-inducing kinase activity 9174053 IDA GO:0004713 protein tyrosine kinase activity 9174053 IDA GO:0004714 transmembrane receptor protein tyrosine kinase activity 19459784 TAS GO:0004714 transmembrane receptor protein tyrosine kinase activity 17681947 22939624 IPI GO:0005515 protein binding IEA GO:0005524 ATP binding 25517749 IPI GO:0042802 identical protein binding,hsa05223 Non-small cell lung cancer - Homo sapiens (human),chemicalprobes.org BAZ2-ICR,Q9UIF9,Bromodomain adjacent to zinc finger domain protein 2A,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,11176,BAZ2A,Epigenetic regulation of gene expression R-HSA-212165 NoRC negatively regulates rRNA expression R-HSA-427413 Negative epigenetic regulation of rRNA expression R-HSA-5250941 Gene Expression R-HSA-74160,nucleoplasm IDA GO:0005654 chromatin silencing complex ISS GO:0005677 nucleolus ISS GO:0005730 cytoplasm IDA GO:0005737 rDNA heterochromatin ISS GO:0033553,"chromatin silencing at rDNA GO:0000183 ISS DNA methylation GO:0006306 ISS chromatin remodeling GO:0006338 NAS 11532953 transcription, DNA-templated GO:0006351 NAS 10662543 regulation of transcription, DNA-templated GO:0006355 NAS 10662543 histone deacetylation GO:0016575 ISS",RNA polymerase I CORE element sequence-specific DNA binding GO:0001164 IDA 22368283 RNA binding GO:0003723 ISS protein binding GO:0005515 IPI 17474147 26100909 zinc ion binding GO:0008270 IEA ligand-dependent nuclear receptor binding GO:0016922 NAS 10662543 histone binding GO:0042393 IPI 22368283 lysine-acetylated histone binding GO:0070577 ISS,,chemicalprobes.org GSK2801,Q9UIF9,Bromodomain adjacent to zinc finger domain protein 2A,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,11176,BAZ2A,Epigenetic regulation of gene expression R-HSA-212165 NoRC negatively regulates rRNA expression R-HSA-427413 Negative epigenetic regulation of rRNA expression R-HSA-5250941 Gene Expression R-HSA-74160,nucleoplasm IDA GO:0005654 chromatin silencing complex ISS GO:0005677 nucleolus ISS GO:0005730 cytoplasm IDA GO:0005737 rDNA heterochromatin ISS GO:0033553,"chromatin silencing at rDNA GO:0000183 ISS DNA methylation GO:0006306 ISS chromatin remodeling GO:0006338 NAS 11532953 transcription, DNA-templated GO:0006351 NAS 10662543 regulation of transcription, DNA-templated GO:0006355 NAS 10662543 histone deacetylation GO:0016575 ISS",RNA polymerase I CORE element sequence-specific DNA binding GO:0001164 IDA 22368283 RNA binding GO:0003723 ISS protein binding GO:0005515 IPI 17474147 26100909 zinc ion binding GO:0008270 IEA ligand-dependent nuclear receptor binding GO:0016922 NAS 10662543 histone binding GO:0042393 IPI 22368283 lysine-acetylated histone binding GO:0070577 ISS,,chemicalprobes.org BAZ2-ICR,Q9UIF8,Bromodomain adjacent to zinc finger domain protein 2B,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,29994,BAZ2B,,GO:0005634 nucleus IEA,"NAS 10662543 transcription, DNA-templated GO:0006351 NAS 10662543 regulation of transcription, DNA-templated GO:0006355",IEA GO:0003677 DNA binding IPI 10662543 protein binding GO:0005515 IEA GO:0008270 zinc ion binding,,chemicalprobes.org GSK2801,Q9UIF8,Bromodomain adjacent to zinc finger domain protein 2B,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,29994,BAZ2B,,GO:0005634 nucleus IEA,"NAS 10662543 transcription, DNA-templated GO:0006351 NAS 10662543 regulation of transcription, DNA-templated GO:0006355",IEA GO:0003677 DNA binding IPI 10662543 protein binding GO:0005515 IEA GO:0008270 zinc ion binding,,chemicalprobes.org JQ1,P25440,Bromodomain-containing protein 2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,6046,BRD2,,nucleus GO:0005634 IEA cytoplasm GO:0005737 IEA,"18406326 GO:0006334 nucleosome assembly IMP GO:0006351 transcription, DNA-templated IEA 18406326 GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 9693039 GO:0007283 spermatogenesis TAS GO:0016568 chromatin modification IEA",GO:0003682 chromatin binding 18406326 IDA GO:0005515 protein binding 20709061 24229708 IPI GO:0070577 lysine-acetylated histone binding 18406326 IDA,,chemicalprobes.org PFI-1,P25440,Bromodomain-containing protein 2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,6046,BRD2,,nucleus GO:0005634 IEA cytoplasm GO:0005737 IEA,"18406326 GO:0006334 nucleosome assembly IMP GO:0006351 transcription, DNA-templated IEA 18406326 GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 9693039 GO:0007283 spermatogenesis TAS GO:0016568 chromatin modification IEA",GO:0003682 chromatin binding 18406326 IDA GO:0005515 protein binding 20709061 24229708 IPI GO:0070577 lysine-acetylated histone binding 18406326 IDA,,chemicalprobes.org I-BET151,P25440,Bromodomain-containing protein 2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,6046,BRD2,,nucleus GO:0005634 IEA cytoplasm GO:0005737 IEA,"18406326 GO:0006334 nucleosome assembly IMP GO:0006351 transcription, DNA-templated IEA 18406326 GO:0006357 regulation of transcription from RNA polymerase II promoter IDA 9693039 GO:0007283 spermatogenesis TAS GO:0016568 chromatin modification IEA",GO:0003682 chromatin binding 18406326 IDA GO:0005515 protein binding 20709061 24229708 IPI GO:0070577 lysine-acetylated histone binding 18406326 IDA,,chemicalprobes.org JQ1,Q15059,Bromodomain-containing protein 3,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,8019,BRD3,,nucleus GO:0005634 IEA,"transcription, DNA-templated IEA GO:0006351 regulation of transcription from RNA polymerase II promoter IDA 18406326 GO:0006357 chromatin modification IEA GO:0016568",chromatin binding GO:0003682 IDA 18406326 protein binding GO:0005515 IPI 20195357 lysine-acetylated histone binding GO:0070577 IDA 22464331,,chemicalprobes.org PFI-1,Q15059,Bromodomain-containing protein 3,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,8019,BRD3,,nucleus GO:0005634 IEA,"transcription, DNA-templated IEA GO:0006351 regulation of transcription from RNA polymerase II promoter IDA 18406326 GO:0006357 chromatin modification IEA GO:0016568",chromatin binding GO:0003682 IDA 18406326 protein binding GO:0005515 IPI 20195357 lysine-acetylated histone binding GO:0070577 IDA 22464331,,chemicalprobes.org I-BET151,Q15059,Bromodomain-containing protein 3,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,8019,BRD3,,nucleus GO:0005634 IEA,"transcription, DNA-templated IEA GO:0006351 regulation of transcription from RNA polymerase II promoter IDA 18406326 GO:0006357 chromatin modification IEA GO:0016568",chromatin binding GO:0003682 IDA 18406326 protein binding GO:0005515 IPI 20195357 lysine-acetylated histone binding GO:0070577 IDA 22464331,,chemicalprobes.org JQ1,O60885,Bromodomain-containing protein 4,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,23476,BRD4,,10938129 GO:0000794 condensed nuclear chromosome IDA 20871596 GO:0005634 nucleus IDA GO:0005654 nucleoplasm IDA GO:0005737 cytoplasm IDA,"GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle 18039861 IMP GO:0006351 transcription, DNA-templated IEA GO:0006974 cellular response to DNA damage stimulus IEA GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 10938129 IMP GO:0016032 viral process IEA GO:0016568 chromatin modification IEA GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter 19103749 23086925 IDA GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter 18039861 IMP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 19103749 IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter 23086925 23317504 IDA GO:0050727 regulation of inflammatory response 19103749 IDA GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain 23086925 IDA",IDA 23317504 p53 binding GO:0002039 IDA 20871596 23086925 23317504 chromatin binding GO:0003682 IPI 17023018 17189189 17474147 18305892 19103749 22645123 23455924 23686307 24360279 24525235 protein binding GO:0005515 IDA 20871596 23086925 23317504 lysine-acetylated histone binding GO:0070577,,chemicalprobes.org PFI-1,O60885,Bromodomain-containing protein 4,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,23476,BRD4,,10938129 GO:0000794 condensed nuclear chromosome IDA 20871596 GO:0005634 nucleus IDA GO:0005654 nucleoplasm IDA GO:0005737 cytoplasm IDA,"GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle 18039861 IMP GO:0006351 transcription, DNA-templated IEA GO:0006974 cellular response to DNA damage stimulus IEA GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 10938129 IMP GO:0016032 viral process IEA GO:0016568 chromatin modification IEA GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter 19103749 23086925 IDA GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter 18039861 IMP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 19103749 IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter 23086925 23317504 IDA GO:0050727 regulation of inflammatory response 19103749 IDA GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain 23086925 IDA",IDA 23317504 p53 binding GO:0002039 IDA 20871596 23086925 23317504 chromatin binding GO:0003682 IPI 17023018 17189189 17474147 18305892 19103749 22645123 23455924 23686307 24360279 24525235 protein binding GO:0005515 IDA 20871596 23086925 23317504 lysine-acetylated histone binding GO:0070577,,chemicalprobes.org I-BET151,O60885,Bromodomain-containing protein 4,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,23476,BRD4,,10938129 GO:0000794 condensed nuclear chromosome IDA 20871596 GO:0005634 nucleus IDA GO:0005654 nucleoplasm IDA GO:0005737 cytoplasm IDA,"GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle 18039861 IMP GO:0006351 transcription, DNA-templated IEA GO:0006974 cellular response to DNA damage stimulus IEA GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 10938129 IMP GO:0016032 viral process IEA GO:0016568 chromatin modification IEA GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter 19103749 23086925 IDA GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter 18039861 IMP GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 19103749 IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter 23086925 23317504 IDA GO:0050727 regulation of inflammatory response 19103749 IDA GO:1901407 regulation of phosphorylation of RNA polymerase II C-terminal domain 23086925 IDA",IDA 23317504 p53 binding GO:0002039 IDA 20871596 23086925 23317504 chromatin binding GO:0003682 IPI 17023018 17189189 17474147 18305892 19103749 22645123 23455924 23686307 24360279 24525235 protein binding GO:0005515 IDA 20871596 23086925 23317504 lysine-acetylated histone binding GO:0070577,,chemicalprobes.org BI-9564,Q9NPI1,Bromodomain-containing protein 7,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,29117,BRD7,,11025449 12489984 16265664 20228809 21630459 IDA GO:0005634 nucleus TAS GO:0005654 nucleoplasm IDA GO:0005737 cytoplasm IEA GO:0090544 BAF-type complex,"transcription, DNA-templated IEA GO:0006351 regulation of transcription from RNA polymerase II promoter IDA 12489984 GO:0006357 cell cycle IEA GO:0007049 negative regulation of cell proliferation IDA 20228809 GO:0008285 Wnt signaling pathway IEA GO:0016055 positive regulation of histone acetylation IDA 20228809 GO:0035066 negative regulation of transcription, DNA-templated IDA 16265664 GO:0045892 positive regulation of transcription, DNA-templated IDA 20228809 GO:0045893 regulation of signal transduction by p53 class mediator TAS GO:1901796 negative regulation of G1/S transition of mitotic cell cycle IDA 16265664 GO:2000134",p53 binding IPI 20228809 GO:0002039 transcription coactivator activity IDA 20228809 GO:0003713 transcription corepressor activity IDA 16265664 GO:0003714 transcription corepressor activity ISS GO:0003714 protein binding IPI 12489984 18329849 20228809 GO:0005515 transcription factor binding IDA 11025449 GO:0008134 histone binding IDA 12489984 GO:0042393 transcription regulatory region DNA binding IDA 20228809 GO:0044212 lysine-acetylated histone binding IDA 16265664 GO:0070577,,chemicalprobes.org LP99,Q9NPI1,Bromodomain-containing protein 7,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,29117,BRD7,,11025449 12489984 16265664 20228809 21630459 IDA GO:0005634 nucleus TAS GO:0005654 nucleoplasm IDA GO:0005737 cytoplasm IEA GO:0090544 BAF-type complex,"transcription, DNA-templated IEA GO:0006351 regulation of transcription from RNA polymerase II promoter IDA 12489984 GO:0006357 cell cycle IEA GO:0007049 negative regulation of cell proliferation IDA 20228809 GO:0008285 Wnt signaling pathway IEA GO:0016055 positive regulation of histone acetylation IDA 20228809 GO:0035066 negative regulation of transcription, DNA-templated IDA 16265664 GO:0045892 positive regulation of transcription, DNA-templated IDA 20228809 GO:0045893 regulation of signal transduction by p53 class mediator TAS GO:1901796 negative regulation of G1/S transition of mitotic cell cycle IDA 16265664 GO:2000134",p53 binding IPI 20228809 GO:0002039 transcription coactivator activity IDA 20228809 GO:0003713 transcription corepressor activity IDA 16265664 GO:0003714 transcription corepressor activity ISS GO:0003714 protein binding IPI 12489984 18329849 20228809 GO:0005515 transcription factor binding IDA 11025449 GO:0008134 histone binding IDA 12489984 GO:0042393 transcription regulatory region DNA binding IDA 20228809 GO:0044212 lysine-acetylated histone binding IDA 16265664 GO:0070577,,chemicalprobes.org I-BRD9,Q9H8M2,Bromodomain-containing protein 9,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,65980,BRD9,,cellular_component ND GO:0005575,"IEA GO:0006351 transcription, DNA-templated IEA GO:0006355 regulation of transcription, DNA-templated ND GO:0008150 biological_process IEA GO:0016568 chromatin modification",18559093 NAS GO:0003676 nucleic acid binding 25416956 IPI GO:0005515 protein binding 22464331 IDA GO:0070577 lysine-acetylated histone binding,,chemicalprobes.org BI-9564,Q9H8M2,Bromodomain-containing protein 9,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,65980,BRD9,,cellular_component ND GO:0005575,"IEA GO:0006351 transcription, DNA-templated IEA GO:0006355 regulation of transcription, DNA-templated ND GO:0008150 biological_process IEA GO:0016568 chromatin modification",18559093 NAS GO:0003676 nucleic acid binding 25416956 IPI GO:0005515 protein binding 22464331 IDA GO:0070577 lysine-acetylated histone binding,,chemicalprobes.org LP99,Q9H8M2,Bromodomain-containing protein 9,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,65980,BRD9,,cellular_component ND GO:0005575,"IEA GO:0006351 transcription, DNA-templated IEA GO:0006355 regulation of transcription, DNA-templated ND GO:0008150 biological_process IEA GO:0016568 chromatin modification",18559093 NAS GO:0003676 nucleic acid binding 25416956 IPI GO:0005515 protein binding 22464331 IDA GO:0070577 lysine-acetylated histone binding,,chemicalprobes.org JQ1,Q58F21,Bromodomain testis-specific protein,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,676,BRDT,,nucleus ISS GO:0005634,"histone displacement GO:0001207 ISS chromatin remodeling GO:0006338 ISS transcription, DNA-templated GO:0006351 IEA mRNA processing GO:0006397 IEA male meiosis GO:0007140 ISS male meiosis I GO:0007141 ISS spermatogenesis GO:0007283 ISS RNA splicing GO:0008380 IEA cell differentiation GO:0030154 IEA regulation of RNA splicing GO:0043484 ISS positive regulation of transcription involved in meiotic cell cycle GO:0051039 ISS",10365964 TAS GO:0003713 transcription coactivator activity 22464331 IDA GO:0042393 histone binding ISS GO:0070577 lysine-acetylated histone binding,,chemicalprobes.org PFI-1,Q58F21,Bromodomain testis-specific protein,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,676,BRDT,,nucleus ISS GO:0005634,"histone displacement GO:0001207 ISS chromatin remodeling GO:0006338 ISS transcription, DNA-templated GO:0006351 IEA mRNA processing GO:0006397 IEA male meiosis GO:0007140 ISS male meiosis I GO:0007141 ISS spermatogenesis GO:0007283 ISS RNA splicing GO:0008380 IEA cell differentiation GO:0030154 IEA regulation of RNA splicing GO:0043484 ISS positive regulation of transcription involved in meiotic cell cycle GO:0051039 ISS",10365964 TAS GO:0003713 transcription coactivator activity 22464331 IDA GO:0042393 histone binding ISS GO:0070577 lysine-acetylated histone binding,,chemicalprobes.org STO609,Q8N5S9,CaM-kinase kinase alpha,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,84254,KKCC1,Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-112314 Transmission across Chemical Synapses R-HSA-112315 Neuronal System R-HSA-112316 Post NMDA receptor activation events R-HSA-438064 CREB phosphorylation through the activation of CaMKK R-HSA-442717 Activation of NMDA receptor upon glutamate binding and postsynaptic events R-HSA-442755,GO:0005634 nucleus IEA GO:0005829 cytosol TAS,IEA GO:0006468 protein phosphorylation IEA GO:0032147 activation of protein kinase activity,calmodulin-dependent protein kinase activity GO:0004683 TAS protein binding GO:0005515 18242179 IPI calmodulin binding GO:0005516 IEA ATP binding GO:0005524 IEA,hsa04152 AMPK signaling pathway - Homo sapiens (human) hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) hsa04921 Oxytocin signaling pathway - Homo sapiens (human) hsa05034 Alcoholism - Homo sapiens (human),chemicalprobes.org STO609,Q96RR4,CaM-kinase kinase beta,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10645,KKCC2,,intracellular GO:0005622 TAS 11395482 nucleus GO:0005634 IEA cytoplasm GO:0005737 IDA cell projection GO:0042995 IEA,"MAPK cascade GO:0000165 11395482 TAS protein phosphorylation GO:0006468 11395482 IDA peptidyl-tyrosine phosphorylation GO:0018108 IEA calcium-mediated signaling GO:0019722 11395482 TAS regulation of protein kinase activity GO:0045859 11395482 TAS positive regulation of transcription, DNA-templated GO:0045893 11395482 TAS protein autophosphorylation GO:0046777 11395482 IDA",calmodulin-dependent protein kinase activity GO:0004683 IEA protein tyrosine kinase activity 11395482 GO:0004713 TAS calcium ion binding 11395482 GO:0005509 IDA calmodulin binding 11395482 GO:0005516 TAS ATP binding GO:0005524 IEA,AMPK signaling pathway - Homo sapiens (human) hsa04152 Adipocytokine signaling pathway - Homo sapiens (human) hsa04920 Oxytocin signaling pathway - Homo sapiens (human) hsa04921 Alcoholism - Homo sapiens (human) hsa05034,chemicalprobes.org PF-4800567,P49674,Casein kinase I epsilon,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,102800317,KC1E,"R-HSA-162582 Signal Transduction R-HSA-1640170 Cell Cycle R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-195721 Signaling by Wnt R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-201688 WNT mediated activation of DVL R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organizationfrom the centrosome R-HSA-380287 Centrosome maturation R-HSA-400253 Circadian Clock R-HSA-453274 Mitotic G2-G2/M phases R-HSA-5617833 Assembly of the primary cilium R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-69275 G2/M Transition R-HSA-69278 Cell Cycle, Mitotic",nucleus IBA GO:0005634 nucleus ISS GO:0005634 nucleoplasm TAS GO:0005654 cytoplasm IDA 17244647 GO:0005737 cytosol TAS GO:0005829 intracellular ribonucleoprotein complex IEA GO:0030529,TAS GO:0000086 G2/M transition of mitotic cell cycle 7797465 TAS GO:0006281 DNA repair TAS GO:0006364 rRNA processing 15917222 17244647 IDA GO:0006468 protein phosphorylation ISS GO:0006468 protein phosphorylation IBA GO:0006897 endocytosis 7797465 TAS GO:0007165 signal transduction IBA GO:0008360 regulation of cell shape IBA GO:0016055 Wnt signaling pathway 25500533 IDA GO:0018105 peptidyl-serine phosphorylation IEA GO:0030178 negative regulation of Wnt signaling pathway 23109420 IDA GO:0032091 negative regulation of protein binding ISS GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS GO:0032922 circadian regulation of gene expression IEA GO:0034613 cellular protein localization ISS GO:0042752 regulation of circadian rhythm 17244647 NAS GO:0071542 dopaminergic neuron differentiation IEA GO:0090263 positive regulation of canonical Wnt signaling pathway 17244647 IDA GO:1903827 regulation of cellular protein localization 17244647 IC GO:2000052 positive regulation of non-canonical Wnt signaling pathway,17244647 IDA GO:0004672 protein kinase activity ISS GO:0004672 protein kinase activity 15917222 25500533 IDA GO:0004674 protein serine/threonine kinase activity 7797465 TAS GO:0004674 protein serine/threonine kinase activity 11425858 15917222 16616143 16618118 17218255 17244647 20708156 21900206 21988832 22609948 22682247 22939624 23109420 23455922 25241761 25416956 26496610 IPI GO:0005515 protein binding IEA GO:0005524 ATP binding 22681889 IDA GO:0044822 poly(A) RNA binding,FoxO signaling pathway - Homo sapiens (human) hsa04068 Wnt signaling pathway - Homo sapiens (human) hsa04310 Hedgehog signaling pathway - Homo sapiens (human) hsa04340 Hippo signaling pathway - Homo sapiens (human) hsa04390 Circadian rhythm - Homo sapiens (human) hsa04710,chemicalprobes.org CX-4945,P68400,Casein kinase II alpha,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,1457,CSK21,"R-HSA-1266738 Developmental Biology R-HSA-162582 Signal Transduction R-HSA-1640170 Cell Cycle R-HSA-195721 Signaling by Wnt R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-201688 WNT mediated activation of DVL R-HSA-2514853 Condensation of Prometaphase Chromosomes R-HSA-373760 L1CAM interactions R-HSA-422475 Axon guidance R-HSA-445144 Signal transduction by L1 R-HSA-68877 Mitotic Prometaphase R-HSA-68886 M Phase R-HSA-69278 Cell Cycle, Mitotic",nucleus IDA 21282530 21630459 GO:0005634 nucleoplasm TAS GO:0005654 cytosol TAS GO:0005829 plasma membrane TAS 10799509 GO:0005886 Sin3 complex IDA 17827154 GO:0016580 NuRD complex IDA 17827154 GO:0016581 colocalizes_with PcG protein complex IDA 21282530 GO:0031519,"IEA GO:0006351 transcription, DNA-templated IEA GO:0006355 regulation of transcription, DNA-templated TAS GO:0006457 protein folding IDA 20625391 22406621 protein phosphorylation GO:0006468 TAS 2174700 signal transduction GO:0007165 IDA 20625391 positive regulation of cell proliferation GO:0008284 IEA GO:0016055 Wnt signaling pathway IMP 12700239 positive regulation of Wnt signaling pathway GO:0030177 IDA 20625391 positive regulation of cell growth GO:0030307 IMP 16193064 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IDA 20625391 positive regulation of protein catabolic process GO:0045732 IEA GO:0046777 protein autophosphorylation IEA GO:0048511 rhythmic process IEA GO:0050790 regulation of catalytic activity TAS 19387550 chaperone-mediated protein folding GO:0061077 IMP 11704824 mitotic spindle checkpoint GO:0071174 TAS GO:1901796 regulation of signal transduction by p53 class mediator",12700239 16193064 20625391 20864032 IDA GO:0004674 protein serine/threonine kinase activity 11035045 IMP GO:0004674 protein serine/threonine kinase activity 2174700 TAS GO:0004674 protein serine/threonine kinase activity 10094392 11574463 12191471 12769847 14667819 16873060 19011756 19236849 19680552 20625391 21282530 21516116 21968188 21988832 22113938 22317921 22406621 22975381 23455922 23555304 23752268 24535599 25241761 25416956 25852190 26711270 IPI GO:0005515 protein binding IEA GO:0005524 ATP binding IEA GO:0008013 beta-catenin binding IEA GO:0019888 protein phosphatase regulator activity 11972058 IPI GO:0047485 protein N-terminus binding 19387550 TAS GO:0051879 Hsp90 protein binding,Ribosome biogenesis in eukaryotes - Homo sapiens (human) hsa03008 NF-kappa B signaling pathway - Homo sapiens (human) hsa04064 Wnt signaling pathway - Homo sapiens (human) hsa04310 Adherens junction - Homo sapiens (human) hsa04520 Tight junction - Homo sapiens (human) hsa04530 Measles - Homo sapiens (human) hsa05162 Herpes simplex infection - Homo sapiens (human) hsa05168 Epstein-Barr virus infection - Homo sapiens (human) hsa05169,chemicalprobes.org JNK-IN-8,P45983,c-Jun N-terminal kinase 1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,5599,MK08,"R-HSA-109581 Apoptosis R-HSA-109606 Intrinsic Pathway for Apoptosis R-HSA-111446 Activation of BIM and translocation to mitochondria R-HSA-114452 Activation of BH3-only proteins R-HSA-139910 Activation of BMF and translocation to mitochondria R-HSA-1500931 Cell-Cell communication R-HSA-162582 Signal Transduction R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166054 Activated TLR4 signalling R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-166166 MyD88-independent TLR3/TLR4 cascade R-HSA-166520 Signalling by NGF R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168180 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-168898 Toll-Like Receptors Cascades R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-193648 NRAGE signals death through JNK R-HSA-193704 p75 NTR receptor-mediated signalling R-HSA-204998 Cell death signalling via NRAGE, NRIF and NADE R-HSA-205043 NRIF signals cell death from the nucleus R-HSA-2262752 Cellular responses to stress R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-2559583 Cellular Senescence R-HSA-2871796 FCERI mediated MAPK activation R-HSA-376172 DSCAM interactions R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450294 MAP kinase activation in TLR cascade R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450341 Activation of the AP-1 family of transcription factors R-HSA-5357801 Programmed Cell Death R-HSA-937061 TRIF-mediated TLR3/TLR4 signaling R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-975871 MyD88 cascade initiated on plasma membrane",20027304 GO:0005634 nucleus IDA GO:0005654 nucleoplasm TAS GO:0005739 mitochondrion IEA GO:0005829 cytosol TAS,protein phosphorylation GO:0006468 IMP 22441692 response to stress GO:0006950 TAS 8137421 JNK cascade GO:0007254 IDA 8654373 JNK cascade GO:0007254 TAS JUN phosphorylation GO:0007258 IDA 14967141 21095239 response to UV GO:0009411 IDA 14967141 positive regulation of gene expression GO:0010628 IMP 22065586 regulation of macroautophagy GO:0016241 TAS 26546165 peptidyl-serine phosphorylation GO:0018105 IDA 15850461 20027304 21095239 peptidyl-threonine phosphorylation GO:0018107 IDA 21095239 peptidyl-threonine phosphorylation GO:0018107 IMP 20027304 regulation of histone deacetylation GO:0031063 IEA positive regulation of cyclase activity GO:0031281 IMP 22027397 negative regulation of protein binding GO:0032091 IDA 21095239 regulation of protein localization GO:0032880 IDA 20027304 Fc-epsilon receptor signaling pathway GO:0038095 TAS regulation of circadian rhythm GO:0042752 ISS positive regulation of apoptotic process GO:0043065 TAS negative regulation of apoptotic process GO:0043066 IDA 14967141 21095239 rhythmic process GO:0048511 IEA regulation of sequence-specific DNA binding transcription factor activity GO:0051090 TAS positive regulation of protein metabolic process GO:0051247 IMP 22027397 cellular response to lipopolysaccharide GO:0071222 IDA 23776175 cellular response to mechanical stimulus GO:0071260 IEP 19593445 positive regulation of deacetylase activity GO:0090045 IMP 20027304 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 TAS,IDA 14967141 15850461 20027304 21095239 protein serine/threonine kinase activity GO:0004674 IDA 8654373 21095239 JUN kinase activity GO:0004705 TAS GO:0004705 JUN kinase activity IPI 10393177 10490659 10856240 11517249 15334056 15894542 16291755 16533805 16840345 16982329 18286207 19234442 19527717 23397142 25241761 25284480 protein binding GO:0005515 IEA GO:0005524 ATP binding TAS GO:0016301 kinase activity IPI 14615289 enzyme binding GO:0019899 IMP 20027304 histone deacetylase regulator activity GO:0035033 IPI 20027304 histone deacetylase binding GO:0042826,MAPK signaling pathway - Homo sapiens (human) hsa04010 ErbB signaling pathway - Homo sapiens (human) hsa04012 Ras signaling pathway - Homo sapiens (human) hsa04014 cAMP signaling pathway - Homo sapiens (human) hsa04024 FoxO signaling pathway - Homo sapiens (human) hsa04068 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 Protein processing in endoplasmic reticulum - Homo sapiens (human) hsa04141 Wnt signaling pathway - Homo sapiens (human) hsa04310 Osteoclast differentiation - Homo sapiens (human) hsa04380 Focal adhesion - Homo sapiens (human) hsa04510 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04620 NOD-like receptor signaling pathway - Homo sapiens (human) hsa04621 RIG-I-like receptor signaling pathway - Homo sapiens (human) hsa04622 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04664 TNF signaling pathway - Homo sapiens (human) hsa04668 Neurotrophin signaling pathway - Homo sapiens (human) hsa04722 Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04723 Dopaminergic synapse - Homo sapiens (human) hsa04728 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04750 Insulin signaling pathway - Homo sapiens (human) hsa04910 GnRH signaling pathway - Homo sapiens (human) hsa04912 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04914 Prolactin signaling pathway - Homo sapiens (human) hsa04917 Adipocytokine signaling pathway - Homo sapiens (human) hsa04920 Type II diabetes mellitus - Homo sapiens (human) hsa04930 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa04932 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) hsa05120 Shigellosis - Homo sapiens (human) hsa05131 Salmonella infection - Homo sapiens (human) hsa05132 Pertussis - Homo sapiens (human) hsa05133 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05142 Toxoplasmosis - Homo sapiens (human) hsa05145 Tuberculosis - Homo sapiens (human) hsa05152 Hepatitis C - Homo sapiens (human) hsa05160 Hepatitis B - Homo sapiens (human) hsa05161 Influenza A - Homo sapiens (human) hsa05164 HTLV-I infection - Homo sapiens (human) hsa05166 Herpes simplex infection - Homo sapiens (human) hsa05168 Epstein-Barr virus infection - Homo sapiens (human) hsa05169 Pathways in cancer - Homo sapiens (human) hsa05200 Colorectal cancer - Homo sapiens (human) hsa05210 Pancreatic cancer - Homo sapiens (human) hsa05212 Choline metabolism in cancer - Homo sapiens (human) hsa05231,chemicalprobes.org JNK-IN-8,P45984,c-Jun N-terminal kinase 2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,5601,MK09,Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 Activated TLR4 signalling R-HSA-166054 MyD88:Mal cascade initiated on plasma membrane R-HSA-166058 MyD88-independent TLR3/TLR4 cascade R-HSA-166166 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168180 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Toll-Like Receptors Cascades R-HSA-168898 Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 Cellular responses to stress R-HSA-2262752 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Oxidative Stress Induced Senescence R-HSA-2559580 Cellular Senescence R-HSA-2559583 FCERI mediated MAPK activation R-HSA-2871796 MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 MAP kinase activation in TLR cascade R-HSA-450294 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 Activation of the AP-1 family of transcription factors R-HSA-450341 TRIF-mediated TLR3/TLR4 signaling R-HSA-937061 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 MyD88 dependent cascade initiated on endosome R-HSA-975155 MyD88 cascade initiated on plasma membrane R-HSA-975871,nucleoplasm TAS GO:0005654 mitochondrion IEA GO:0005739 cytosol TAS GO:0005829,"IEA GO:0001836 release of cytochrome c from mitochondria IEA GO:0001934 positive regulation of protein phosphorylation IMP 22441692 protein phosphorylation GO:0006468 IEA GO:0006626 protein targeting to mitochondrion IEA GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS 7969172 response to stress GO:0006950 IDA 8654373 JNK cascade GO:0007254 TAS GO:0007254 JNK cascade IEA GO:0007258 JUN phosphorylation IEA GO:0007417 central nervous system development IEA GO:0009612 response to mechanical stimulus IEA GO:0009636 response to toxic substance IMP 18262097 positive regulation of gene expression GO:0010628 IMP 18262097 positive regulation of macrophage derived foam cell differentiation GO:0010744 IEA GO:0010770 positive regulation of cell morphogenesis involved in differentiation IEA GO:0014075 response to amine IEA GO:0031175 neuron projection development IEA GO:0031394 positive regulation of prostaglandin biosynthetic process IEA GO:0031396 regulation of protein ubiquitination IEA GO:0032308 positive regulation of prostaglandin secretion IEA GO:0032722 positive regulation of chemokine production IEA GO:0034644 cellular response to UV TAS GO:0038095 Fc-epsilon receptor signaling pathway IEA GO:0042493 response to drug ISS GO:0042752 regulation of circadian rhythm IEA GO:0045429 positive regulation of nitric oxide biosynthetic process IEA GO:0045893 positive regulation of transcription, DNA-templated IEA GO:0046328 regulation of JNK cascade IEA GO:0046686 response to cadmium ion IEA GO:0048511 rhythmic process TAS GO:0051090 regulation of sequence-specific DNA binding transcription factor activity IEA GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IEA GO:0071222 cellular response to lipopolysaccharide IEA GO:0071347 cellular response to interleukin-1 IEA GO:0071356 cellular response to tumor necrosis factor IEA GO:0071363 cellular response to growth factor stimulus IEA GO:0071803 positive regulation of podosome assembly IEA GO:2001235 positive regulation of apoptotic signaling pathway",8654373 IDA GO:0004705 JUN kinase activity 10376527 15158451 16189514 19060904 20871632 21988832 25416956 IPI GO:0005515 protein binding IEA GO:0005524 ATP binding 10376527 IDA GO:0008134 transcription factor binding IEA GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process IEA GO:0031435 mitogen-activated protein kinase kinase kinase binding,MAPK signaling pathway - Homo sapiens (human) hsa04010 ErbB signaling pathway - Homo sapiens (human) hsa04012 Ras signaling pathway - Homo sapiens (human) hsa04014 cAMP signaling pathway - Homo sapiens (human) hsa04024 FoxO signaling pathway - Homo sapiens (human) hsa04068 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 Protein processing in endoplasmic reticulum - Homo sapiens (human) hsa04141 Wnt signaling pathway - Homo sapiens (human) hsa04310 Osteoclast differentiation - Homo sapiens (human) hsa04380 Focal adhesion - Homo sapiens (human) hsa04510 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04620 NOD-like receptor signaling pathway - Homo sapiens (human) hsa04621 RIG-I-like receptor signaling pathway - Homo sapiens (human) hsa04622 T cell receptor signaling pathway - Homo sapiens (human) hsa04660 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04664 TNF signaling pathway - Homo sapiens (human) hsa04668 Neurotrophin signaling pathway - Homo sapiens (human) hsa04722 Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04723 Dopaminergic synapse - Homo sapiens (human) hsa04728 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04750 Insulin signaling pathway - Homo sapiens (human) hsa04910 GnRH signaling pathway - Homo sapiens (human) hsa04912 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04914 Prolactin signaling pathway - Homo sapiens (human) hsa04917 Adipocytokine signaling pathway - Homo sapiens (human) hsa04920 Type II diabetes mellitus - Homo sapiens (human) hsa04930 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa04932 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) hsa05120 Shigellosis - Homo sapiens (human) hsa05131 Salmonella infection - Homo sapiens (human) hsa05132 Pertussis - Homo sapiens (human) hsa05133 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05142 Toxoplasmosis - Homo sapiens (human) hsa05145 Tuberculosis - Homo sapiens (human) hsa05152 Hepatitis C - Homo sapiens (human) hsa05160 Hepatitis B - Homo sapiens (human) hsa05161 Influenza A - Homo sapiens (human) hsa05164 Herpes simplex infection - Homo sapiens (human) hsa05168 Epstein-Barr virus infection - Homo sapiens (human) hsa05169 Pathways in cancer - Homo sapiens (human) hsa05200 Colorectal cancer - Homo sapiens (human) hsa05210 Pancreatic cancer - Homo sapiens (human) hsa05212 Choline metabolism in cancer - Homo sapiens (human) hsa05231,chemicalprobes.org JNK-IN-8,P53779,c-Jun N-terminal kinase 3,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,5602,MK10,R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166054 Activated TLR4 signalling R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-166166 MyD88-independent TLR3/TLR4 cascade R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168180 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-168898 Toll-Like Receptors Cascades R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-2262752 Cellular responses to stress R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-2559583 Cellular Senescence R-HSA-2871796 FCERI mediated MAPK activation R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450294 MAP kinase activation in TLR cascade R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450341 Activation of the AP-1 family of transcription factors R-HSA-937061 TRIF-mediated TLR3/TLR4 signaling R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-975871 MyD88 cascade initiated on plasma membrane,GO:0005654 nucleoplasm TAS GO:0005737 cytoplasm ISS GO:0005739 mitochondrion ISS GO:0005829 cytosol TAS GO:0005886 plasma membrane ISS,IEA GO:0000187 activation of MAPK activity 22441692 IMP GO:0006468 protein phosphorylation ISS GO:0006468 protein phosphorylation 8654373 TAS GO:0007165 signal transduction 8654373 ISS GO:0007254 JNK cascade TAS GO:0007254 JNK cascade IEA GO:0007258 JUN phosphorylation ISS GO:0009416 response to light stimulus TAS GO:0038095 Fc-epsilon receptor signaling pathway ISS GO:0042752 regulation of circadian rhythm IEA GO:0048511 rhythmic process TAS GO:0051090 regulation of sequence-specific DNA binding transcription factor activity,JUN kinase activity GO:0004705 8654373 ISS MAP kinase kinase activity GO:0004708 7826642 TAS protein binding GO:0005515 19527717 19782076 19879840 21988832 IPI ATP binding GO:0005524 IEA,hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04071 Sphingolipid signaling pathway - Homo sapiens (human) hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) hsa04310 Wnt signaling pathway - Homo sapiens (human) hsa04380 Osteoclast differentiation - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human) hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human) hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04668 TNF signaling pathway - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04728 Dopaminergic synapse - Homo sapiens (human) hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04910 Insulin signaling pathway - Homo sapiens (human) hsa04912 GnRH signaling pathway - Homo sapiens (human) hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) hsa04930 Type II diabetes mellitus - Homo sapiens (human) hsa04932 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) hsa05131 Shigellosis - Homo sapiens (human) hsa05132 Salmonella infection - Homo sapiens (human) hsa05133 Pertussis - Homo sapiens (human) hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05152 Tuberculosis - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human) hsa05161 Hepatitis B - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05168 Herpes simplex infection - Homo sapiens (human) hsa05169 Epstein-Barr virus infection - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05210 Colorectal cancer - Homo sapiens (human) hsa05212 Pancreatic cancer - Homo sapiens (human) hsa05231 Choline metabolism in cancer - Homo sapiens (human),chemicalprobes.org SGC-CBP30,Q92793,CREB-binding protein,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,1387,CBP,"R-HSA-1266738 Developmental Biology R-HSA-1430728 Metabolism R-HSA-157052 NICD traffics to nucleus R-HSA-157118 Signaling by NOTCH R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-168928 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA R-HSA-1912408 Pre-NOTCH Transcription and Translation R-HSA-1912422 Pre-NOTCH Expression and Processing R-HSA-195721 Signaling by Wnt R-HSA-1980143 Signaling by NOTCH1 R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-201722 formation of the beta-catenin:TCF transactivating complex R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-212436 Generic Transcription Pathway R-HSA-2262752 Cellular responses to stress R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603 Signaling by NOTCH1 in Cancer R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3214847 HATs acetylate histones R-HSA-3247509 Chromatin modifying enzymes R-HSA-3371556 Cellular response to heat stress R-HSA-3371568 Attenuation phase R-HSA-3371571 HSF1-dependent transactivation R-HSA-350054 Notch-HLH transcription pathway R-HSA-381340 Transcriptional regulation of white adipocyte differentiation R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-4839726 Chromatin organization R-HSA-535734 Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-5621481 C-type lectin receptors (CLRs) R-HSA-5621575 CD209 (DC-SIGN) signaling R-HSA-5663202 Diseases of signal transduction R-HSA-74160 Gene Expression R-HSA-918233 TRAF3-dependent IRF activation pathway R-HSA-933541 TRAF6 mediated IRF7 activation",IEA GO:0000123 histone acetyltransferase complex IDA 21539536 nuclear chromatin GO:0000790 IC 12169688 nucleus GO:0005634 IDA 12929931 nucleus GO:0005634 IDA GO:0005654 nucleoplasm TAS GO:0005654 nucleoplasm IEA GO:0005667 transcription factor complex IDA 12929931 cytoplasm GO:0005737 IDA 15488321 nuclear body GO:0016604,"negative regulation of transcription from RNA polymerase II promoter GO:0000122 21539536 IDA response to hypoxia GO:0001666 15261140 TAS stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS regulation of transcription, DNA-templated GO:0006355 12169688 IDA regulation of transcription, DNA-templated GO:0006355 15261140 TAS transcription initiation from RNA polymerase II promoter GO:0006367 TAS protein complex assembly GO:0006461 7913207 TAS protein acetylation GO:0006473 24939902 IDA signal transduction GO:0007165 15261140 NAS Notch signaling pathway GO:0007219 TAS cell proliferation GO:0008283 IEA regulation of smoothened signaling pathway GO:0008589 11001584 TAS viral process GO:0016032 IEA histone acetylation GO:0016573 11742995 IDA N-terminal peptidyl-lysine acetylation GO:0018076 12435739 IDA positive regulation of type I interferon production GO:0032481 TAS cellular response to UV GO:0034644 24939902 IDA homeostatic process GO:0042592 15261140 NAS embryonic digit morphogenesis GO:0042733 11001584 TAS regulation of apoptotic process GO:0042981 TAS cellular lipid metabolic process GO:0044255 TAS positive regulation of transcription, DNA-templated GO:0045893 11742995 IDA positive regulation of transcription, DNA-templated GO:0045893 ISS positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA rhythmic process GO:0048511 IEA positive regulation of cell adhesion molecule production GO:0060355 IEA regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 TAS response to interleukin-1 GO:0070555 IEA cell-cell adhesion GO:0098609 IEA regulation of cellular response to heat GO:1900034 TAS positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IEA positive regulation of NIK/NF-kappaB signaling GO:1901224 IEA beta-catenin-TCF complex assembly GO:1904837 TAS","core promoter proximal region sequence-specific DNA binding 21539536 GO:0000987 IDA transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding 21539536 GO:0001078 IDA RNA polymerase II transcription factor binding 21539536 GO:0001085 IPI RNA polymerase II activating transcription factor binding 11001584 GO:0001102 TAS RNA polymerase II transcription coactivator activity 11001584 GO:0001105 TAS transcriptional repressor activity, RNA polymerase II transcription factor binding 21539536 GO:0001191 IDA p53 binding 9194565 GO:0002039 IPI chromatin binding 24939902 GO:0003682 IDA damaged DNA binding 24939902 GO:0003684 IDA transcription factor activity, sequence-specific DNA binding 7913207 GO:0003700 TAS transcription coactivator activity 12169688 12435739 12586840 14645221 GO:0003713 IDA transcription coactivator activity contributes_to 12929931 GO:0003713 IDA transcription coactivator activity 8684459 GO:0003713 IPI histone acetyltransferase activity 11742995 GO:0004402 IDA signal transducer activity 7913207 8028671 GO:0004871 TAS protein binding 8684459 9018065 9194564 9687513 9811832 9887100 10049825 10196247 10347196 10428834 10722728 10722738 10823891 10866662 11568182 11799127 11940655 11971985 12435739 12482968 14645221 14716005 15075319 15126506 15220471 15674325 16043483 16291753 16611888 17362989 17382325 17476304 17500595 17923090 18309294 18316612 19234109 20541699 20541704 20581830 21602890 21751375 21903422 23273993 23434580 23441852 24939902 25241761 25314079 25609649 GO:0005515 IPI transcription factor binding 15509593 GO:0008134 IPI zinc ion binding GO:0008270 IEA acetyltransferase activity 12456660 16135789 GO:0016407 EXP acetyltransferase activity 11742995 24939902 GO:0016407 IDA peptide N-acetyltransferase activity GO:0034212 TAS peroxisome proliferator activated receptor binding GO:0042975 IEA MRF binding 8621548 GO:0043426 IDA SMAD binding GO:0046332 IEA","cAMP signaling pathway - Homo sapiens (human) hsa04024 HIF-1 signaling pathway - Homo sapiens (human) hsa04066 FoxO signaling pathway - Homo sapiens (human) hsa04068 Cell cycle - Homo sapiens (human) hsa04110 Wnt signaling pathway - Homo sapiens (human) hsa04310 Notch signaling pathway - Homo sapiens (human) hsa04330 TGF-beta signaling pathway - Homo sapiens (human) hsa04350 Adherens junction - Homo sapiens (human) hsa04520 Jak-STAT signaling pathway - Homo sapiens (human) hsa04630 Long-term potentiation - Homo sapiens (human) hsa04720 Melanogenesis - Homo sapiens (human) hsa04916 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04919 Glucagon signaling pathway - Homo sapiens (human) hsa04922 Huntington,s disease - Homo sapiens (human) hsa05016 Tuberculosis - Homo sapiens (human) hsa05152 Hepatitis B - Homo sapiens (human) hsa05161 Influenza A - Homo sapiens (human) hsa05164 HTLV-I infection - Homo sapiens (human) hsa05166 Herpes simplex infection - Homo sapiens (human) hsa05168 Epstein-Barr virus infection - Homo sapiens (human) hsa05169 Pathways in cancer - Homo sapiens (human) hsa05200 Viral carcinogenesis - Homo sapiens (human) hsa05203 MicroRNAs in cancer - Homo sapiens (human) hsa05206 Renal cell carcinoma - Homo sapiens (human) hsa05211 Prostate cancer - Homo sapiens (human) hsa05215",chemicalprobes.org I-CBP112,Q92793,CREB-binding protein,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,1387,CBP,"R-HSA-1266738 Developmental Biology R-HSA-1430728 Metabolism R-HSA-157052 NICD traffics to nucleus R-HSA-157118 Signaling by NOTCH R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-168928 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA R-HSA-1912408 Pre-NOTCH Transcription and Translation R-HSA-1912422 Pre-NOTCH Expression and Processing R-HSA-195721 Signaling by Wnt R-HSA-1980143 Signaling by NOTCH1 R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-201722 formation of the beta-catenin:TCF transactivating complex R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-212436 Generic Transcription Pathway R-HSA-2262752 Cellular responses to stress R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603 Signaling by NOTCH1 in Cancer R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3214847 HATs acetylate histones R-HSA-3247509 Chromatin modifying enzymes R-HSA-3371556 Cellular response to heat stress R-HSA-3371568 Attenuation phase R-HSA-3371571 HSF1-dependent transactivation R-HSA-350054 Notch-HLH transcription pathway R-HSA-381340 Transcriptional regulation of white adipocyte differentiation R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-4839726 Chromatin organization R-HSA-535734 Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-5621481 C-type lectin receptors (CLRs) R-HSA-5621575 CD209 (DC-SIGN) signaling R-HSA-5663202 Diseases of signal transduction R-HSA-74160 Gene Expression R-HSA-918233 TRAF3-dependent IRF activation pathway R-HSA-933541 TRAF6 mediated IRF7 activation",IEA GO:0000123 histone acetyltransferase complex IDA 21539536 nuclear chromatin GO:0000790 IC 12169688 nucleus GO:0005634 IDA 12929931 nucleus GO:0005634 IDA GO:0005654 nucleoplasm TAS GO:0005654 nucleoplasm IEA GO:0005667 transcription factor complex IDA 12929931 cytoplasm GO:0005737 IDA 15488321 nuclear body GO:0016604,"negative regulation of transcription from RNA polymerase II promoter GO:0000122 21539536 IDA response to hypoxia GO:0001666 15261140 TAS stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS regulation of transcription, DNA-templated GO:0006355 12169688 IDA regulation of transcription, DNA-templated GO:0006355 15261140 TAS transcription initiation from RNA polymerase II promoter GO:0006367 TAS protein complex assembly GO:0006461 7913207 TAS protein acetylation GO:0006473 24939902 IDA signal transduction GO:0007165 15261140 NAS Notch signaling pathway GO:0007219 TAS cell proliferation GO:0008283 IEA regulation of smoothened signaling pathway GO:0008589 11001584 TAS viral process GO:0016032 IEA histone acetylation GO:0016573 11742995 IDA N-terminal peptidyl-lysine acetylation GO:0018076 12435739 IDA positive regulation of type I interferon production GO:0032481 TAS cellular response to UV GO:0034644 24939902 IDA homeostatic process GO:0042592 15261140 NAS embryonic digit morphogenesis GO:0042733 11001584 TAS regulation of apoptotic process GO:0042981 TAS cellular lipid metabolic process GO:0044255 TAS positive regulation of transcription, DNA-templated GO:0045893 11742995 IDA positive regulation of transcription, DNA-templated GO:0045893 ISS positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA rhythmic process GO:0048511 IEA positive regulation of cell adhesion molecule production GO:0060355 IEA regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 TAS response to interleukin-1 GO:0070555 IEA cell-cell adhesion GO:0098609 IEA regulation of cellular response to heat GO:1900034 TAS positive regulation of G1/S transition of mitotic cell cycle GO:1900087 IEA positive regulation of NIK/NF-kappaB signaling GO:1901224 IEA beta-catenin-TCF complex assembly GO:1904837 TAS","core promoter proximal region sequence-specific DNA binding 21539536 GO:0000987 IDA transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding 21539536 GO:0001078 IDA RNA polymerase II transcription factor binding 21539536 GO:0001085 IPI RNA polymerase II activating transcription factor binding 11001584 GO:0001102 TAS RNA polymerase II transcription coactivator activity 11001584 GO:0001105 TAS transcriptional repressor activity, RNA polymerase II transcription factor binding 21539536 GO:0001191 IDA p53 binding 9194565 GO:0002039 IPI chromatin binding 24939902 GO:0003682 IDA damaged DNA binding 24939902 GO:0003684 IDA transcription factor activity, sequence-specific DNA binding 7913207 GO:0003700 TAS transcription coactivator activity 12169688 12435739 12586840 14645221 GO:0003713 IDA transcription coactivator activity contributes_to 12929931 GO:0003713 IDA transcription coactivator activity 8684459 GO:0003713 IPI histone acetyltransferase activity 11742995 GO:0004402 IDA signal transducer activity 7913207 8028671 GO:0004871 TAS protein binding 8684459 9018065 9194564 9687513 9811832 9887100 10049825 10196247 10347196 10428834 10722728 10722738 10823891 10866662 11568182 11799127 11940655 11971985 12435739 12482968 14645221 14716005 15075319 15126506 15220471 15674325 16043483 16291753 16611888 17362989 17382325 17476304 17500595 17923090 18309294 18316612 19234109 20541699 20541704 20581830 21602890 21751375 21903422 23273993 23434580 23441852 24939902 25241761 25314079 25609649 GO:0005515 IPI transcription factor binding 15509593 GO:0008134 IPI zinc ion binding GO:0008270 IEA acetyltransferase activity 12456660 16135789 GO:0016407 EXP acetyltransferase activity 11742995 24939902 GO:0016407 IDA peptide N-acetyltransferase activity GO:0034212 TAS peroxisome proliferator activated receptor binding GO:0042975 IEA MRF binding 8621548 GO:0043426 IDA SMAD binding GO:0046332 IEA","cAMP signaling pathway - Homo sapiens (human) hsa04024 HIF-1 signaling pathway - Homo sapiens (human) hsa04066 FoxO signaling pathway - Homo sapiens (human) hsa04068 Cell cycle - Homo sapiens (human) hsa04110 Wnt signaling pathway - Homo sapiens (human) hsa04310 Notch signaling pathway - Homo sapiens (human) hsa04330 TGF-beta signaling pathway - Homo sapiens (human) hsa04350 Adherens junction - Homo sapiens (human) hsa04520 Jak-STAT signaling pathway - Homo sapiens (human) hsa04630 Long-term potentiation - Homo sapiens (human) hsa04720 Melanogenesis - Homo sapiens (human) hsa04916 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04919 Glucagon signaling pathway - Homo sapiens (human) hsa04922 Huntington,s disease - Homo sapiens (human) hsa05016 Tuberculosis - Homo sapiens (human) hsa05152 Hepatitis B - Homo sapiens (human) hsa05161 Influenza A - Homo sapiens (human) hsa05164 HTLV-I infection - Homo sapiens (human) hsa05166 Herpes simplex infection - Homo sapiens (human) hsa05168 Epstein-Barr virus infection - Homo sapiens (human) hsa05169 Pathways in cancer - Homo sapiens (human) hsa05200 Viral carcinogenesis - Homo sapiens (human) hsa05203 MicroRNAs in cancer - Homo sapiens (human) hsa05206 Renal cell carcinoma - Homo sapiens (human) hsa05211 Prostate cancer - Homo sapiens (human) hsa05215",chemicalprobes.org BMS-265246,P06493,Cyclin-dependent kinase 1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,983,CDK1,"MAPK3 (ERK1) activation R-HSA-110056 RAF-independent MAPK1/3 activation R-HSA-112409 E2F-enabled inhibition of pre-replication complex formation R-HSA-113507 E2F mediated regulation of DNA replication R-HSA-113510 Cyclin B2 mediated events R-HSA-157881 Signal Transduction R-HSA-162582 Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 Cell Cycle R-HSA-1640170 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes R-HSA-170145 APC/C:Cdc20 mediated degradation of Cyclin B R-HSA-174048 APC/C-mediated degradation of cell cycle proteins R-HSA-174143 Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-174184 Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176409 Phosphorylation of the APC/C R-HSA-176412 Phosphorylation of Emi1 R-HSA-176417 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint R-HSA-179419 Organelle biogenesis and maintenance R-HSA-1852241 Condensation of Prophase Chromosomes R-HSA-2299718 MASTL Facilitates Mitotic Progression R-HSA-2465910 Resolution of Sister Chromatid Cohesion R-HSA-2500257 Condensation of Prometaphase Chromosomes R-HSA-2514853 Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 Nuclear Envelope Breakdown R-HSA-2980766 Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 Nuclear Pore Complex (NPC) Disassembly R-HSA-3301854 Loss of Nlp from mitotic centrosomes R-HSA-380259 Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 Loss of proteins required for interphase microtubule organizationfrom the centrosome R-HSA-380284 Centrosome maturation R-HSA-380287 Recruitment of NuMA to mitotic centrosomes R-HSA-380320 Depolymerisation of the Nuclear Lamina R-HSA-4419969 Mitotic G2-G2/M phases R-HSA-453274 Regulation of mitotic cell cycle R-HSA-453276 Mitotic G1-G1/S phases R-HSA-453279 Assembly of the primary cilium R-HSA-5617833 Anchoring of the basal body to the plasma membrane R-HSA-5620912 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 MAPK6/MAPK4 signaling R-HSA-5687128 Mitotic Prophase R-HSA-68875 Mitotic Prometaphase R-HSA-68877 M Phase R-HSA-68886 G1/S Transition R-HSA-69206 Cyclin A/B1 associated events during G2/M transition R-HSA-69273 G2/M Transition R-HSA-69275 Cell Cycle, Mitotic R-HSA-69278 G2/M DNA damage checkpoint R-HSA-69473 G2/M DNA replication checkpoint R-HSA-69478 G2/M Checkpoints R-HSA-69481 Cell Cycle Checkpoints R-HSA-69620 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035","nuclear chromosome, telomeric region 19135898 GO:0000784 IDA nucleus 16109376 GO:0005634 IDA nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 IDA mitochondrion 19917720 GO:0005739 TAS centrosome 17488717 GO:0005813 IDA cytosol GO:0005829 TAS spindle microtubule 11069302 GO:0005876 IDA membrane 19946888 GO:0016020 IDA midbody 11069302 GO:0030496 IDA extracellular exosome 19056867 GO:0070062 IDA mitotic spindle 17488717 GO:0072686 IDA","G1/S transition of mitotic cell cycle GO:0000082 TAS regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083 TAS G2/M transition of mitotic cell cycle GO:0000086 TAS activation of MAPK activity GO:0000187 TAS microtubule cytoskeleton organization GO:0000226 TAS 21655336 DNA replication GO:0006260 TAS 21655336 DNA repair GO:0006281 TAS 21655336 protein complex assembly GO:0006461 IEA apoptotic process GO:0006915 IEA DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 TAS mitotic nuclear division GO:0007067 IEA mitotic nuclear envelope disassembly GO:0007077 TAS mitotic G2 DNA damage checkpoint GO:0007095 IEA centrosome cycle GO:0007098 TAS 19364923 pronuclear fusion GO:0007344 TAS 21535261 cell aging GO:0007569 IEA response to toxic substance GO:0009636 IEA positive regulation of gene expression GO:0010628 IEA regulation of Schwann cell differentiation GO:0014038 TAS 17200138 response to organic cyclic compound GO:0014070 IEA response to amine GO:0014075 IEA response to activity GO:0014823 IEA cell migration GO:0016477 TAS 17200138 histone phosphorylation GO:0016572 IEA peptidyl-serine phosphorylation GO:0018105 IDA 11298763 19879842 peptidyl-threonine phosphorylation GO:0018107 IDA 11298763 chromosome condensation GO:0030261 IEA epithelial cell differentiation GO:0030855 IEP 21492153 organ regeneration GO:0031100 IEA anaphase-promoting complex-dependent catabolic process GO:0031145 TAS positive regulation of protein import into nucleus, translocation GO:0033160 IEA protein localization to kinetochore GO:0034501 IDA 18195732 response to drug GO:0042493 IEA protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 TAS negative regulation of apoptotic process GO:0043066 IDA 11069302 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 TAS response to ethanol GO:0045471 IEA positive regulation of DNA replication GO:0045740 IEA positive regulation of mitotic cell cycle GO:0045931 IEA regulation of embryonic development GO:0045995 TAS 21535261 response to cadmium ion GO:0046686 IEA response to copper ion GO:0046688 IEA response to axon injury GO:0048678 IEA cell division GO:0051301 IEA negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051436 TAS positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0051437 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051439 TAS ventricular cardiac muscle cell development GO:0055015 IEA positive regulation of cardiac muscle cell proliferation GO:0060045 IEA cellular response to hydrogen peroxide GO:0070301 IEA Golgi disassembly GO:0090166 ISS positive regulation of protein localization to nucleus GO:1900182 IMP 21871177",protein kinase activity GO:0004672 IDA 22854038 protein serine/threonine kinase activity GO:0004674 IDA 11298763 19879842 21871177 protein serine/threonine kinase activity GO:0004674 TAS cyclin-dependent protein serine/threonine kinase activity GO:0004693 IDA 11069302 18477460 cyclin-dependent protein serine/threonine kinase activity GO:0004693 TAS protein binding GO:0005515 IPI 7815540 9001210 9988268 10373560 11069302 11574543 11687586 12612082 15148369 17349584 18337751 18408765 18477460 19879842 20395957 21041660 21871177 23602568 24218572 25416956 25852190 26496610 26808496 ATP binding GO:0005524 IEA RNA polymerase II carboxy-terminal domain kinase activity GO:0008353 IDA 12721286 cyclin binding GO:0030332 IEA Hsp70 protein binding GO:0030544 IEA histone kinase activity GO:0035173 IDA 21871177,hsa04110 Cell cycle - Homo sapiens (human) hsa04114 Oocyte meiosis - Homo sapiens (human) hsa04115 p53 signaling pathway - Homo sapiens (human) hsa04540 Gap junction - Homo sapiens (human) hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa05168 Herpes simplex infection - Homo sapiens (human) hsa05169 Epstein-Barr virus infection - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human),chemicalprobes.org BMS-265246,P24941,Cyclin-dependent kinase 2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,1017,CDK2,"R-HSA-109582 Hemostasis R-HSA-1538133 G0 and Early G1 R-HSA-1640170 Cell Cycle R-HSA-174143 APC/C-mediated degradation of cell cycle proteins R-HSA-176187 Activation of ATR in response to replication stress R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 R-HSA-2262752 Cellular responses to stress R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559583 Cellular Senescence R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence R-HSA-453274 Mitotic G2-G2/M phases R-HSA-453276 Regulation of mitotic cell cycle R-HSA-453279 Mitotic G1-G1/S phases R-HSA-68874 M/G1 Transition R-HSA-68911 G2 Phase R-HSA-68949 Orc1 removal from chromatin R-HSA-68962 Activation of the pre-replicative complex R-HSA-69002 DNA Replication Pre-Initiation R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69052 Switching of origins to a post-replicative state R-HSA-69200 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes R-HSA-69202 Cyclin E associated events during G1/S transition R-HSA-69206 G1/S Transition R-HSA-69239 Synthesis of DNA R-HSA-69242 S Phase R-HSA-69273 Cyclin A/B1 associated events during G2/M transition R-HSA-69275 G2/M Transition R-HSA-69278 Cell Cycle, Mitotic R-HSA-69300 Removal of licensing factors from origins R-HSA-69304 Regulation of DNA replication R-HSA-69306 DNA Replication R-HSA-69481 G2/M Checkpoints R-HSA-69563 p53-Dependent G1 DNA Damage Response R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint R-HSA-69615 G1/S DNA Damage Checkpoints R-HSA-69620 Cell Cycle Checkpoints R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry R-HSA-983231 Factors involved in megakaryocyte development and platelet production","8692841 GO:0000307 cyclin-dependent protein kinase holoenzyme complex IDA GO:0000781 chromosome, telomeric region IEA GO:0000793 condensed chromosome IEA GO:0000805 X chromosome IEA GO:0000806 Y chromosome IEA 10767298 GO:0005634 nucleus IDA GO:0005654 nucleoplasm TAS GO:0005667 transcription factor complex IEA 10767298 GO:0005737 cytoplasm IDA 21262353 GO:0005768 endosome IDA 19238148 GO:0005813 centrosome TAS GO:0005829 cytosol TAS 10995387 GO:0015030 Cajal body IDA","TAS GO:0000082 G1/S transition of mitotic cell cycle NAS 1653904 G2/M transition of mitotic cell cycle GO:0000086 TAS GO:0000086 G2/M transition of mitotic cell cycle IEA GO:0002088 lens development in camera-type eye TAS 19238148 DNA replication GO:0006260 IEA GO:0006281 DNA repair IEA GO:0006813 potassium ion transport TAS GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IEA GO:0007067 mitotic nuclear division IMP 26297806 centriole replication GO:0007099 TAS 19238148 meiotic nuclear division GO:0007126 IEP 9054499 Ras protein signal transduction GO:0007265 IDA 10767298 positive regulation of cell proliferation GO:0008284 IEA GO:0009636 response to toxic substance IEA GO:0016572 histone phosphorylation IDA 23184662 peptidyl-serine phosphorylation GO:0018105 IEA GO:0031100 organ regeneration TAS 21319273 mitotic G1 DNA damage checkpoint GO:0031571 IEA GO:0032298 positive regulation of DNA-dependent DNA replication initiation IEA GO:0032355 response to estradiol IEA GO:0032869 cellular response to insulin stimulus IEA GO:0042493 response to drug IEA GO:0045471 response to ethanol IEA GO:0045893 positive regulation of transcription, DNA-templated IEA GO:0046686 response to cadmium ion TAS 19238148 centrosome duplication GO:0051298 IEA GO:0051301 cell division TAS GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle IEA GO:0051591 response to cAMP IEA GO:0051602 response to electrical stimulus IDA 20935635 regulation of gene silencing GO:0060968 TAS 20079829 cellular response to nitric oxide GO:0071732 TAS GO:1901796 regulation of signal transduction by p53 class mediator",TAS GO:0004674 protein serine/threonine kinase activity IDA 21596315 cyclin-dependent protein serine/threonine kinase activity GO:0004693 TAS GO:0004693 cyclin-dependent protein serine/threonine kinase activity IPI 8242750 8521818 8684460 8756328 8756624 9840943 10330164 11463386 11980914 12244298 12361598 12839962 12941338 15107404 15178429 15189033 15232106 15239650 15611625 15890360 16209941 16326706 16458891 16765349 16962592 17053782 17254966 17254967 17418410 19150984 19829063 20098747 20871633 21092281 21596315 21952639 23082202 23455922 23602568 23853094 24218572 25241761 25416956 25852190 26496610 protein binding GO:0005515 IEA GO:0005524 ATP binding TAS GO:0016301 kinase activity IDA 1653904 cyclin binding GO:0030332 IEA GO:0032403 protein complex binding IDA contributes_to 8692841 histone kinase activity GO:0035173 IEA GO:0046872 metal ion binding,FoxO signaling pathway - Homo sapiens (human) hsa04068 Cell cycle - Homo sapiens (human) hsa04110 Oocyte meiosis - Homo sapiens (human) hsa04114 p53 signaling pathway - Homo sapiens (human) hsa04115 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04914 Hepatitis B - Homo sapiens (human) hsa05161 Measles - Homo sapiens (human) hsa05162 Herpes simplex infection - Homo sapiens (human) hsa05168 Epstein-Barr virus infection - Homo sapiens (human) hsa05169 Pathways in cancer - Homo sapiens (human) hsa05200 Viral carcinogenesis - Homo sapiens (human) hsa05203 Prostate cancer - Homo sapiens (human) hsa05215 Small cell lung cancer - Homo sapiens (human) hsa05222,chemicalprobes.org PD0332991,P11802,Cyclin-dependent kinase 4,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,1019,CDK4,"Cell Cycle R-HSA-1640170 Cellular responses to stress R-HSA-2262752 Oxidative Stress Induced Senescence R-HSA-2559580 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 Cellular Senescence R-HSA-2559583 Oncogene Induced Senescence R-HSA-2559585 RMTs methylate histone arginines R-HSA-3214858 Chromatin modifying enzymes R-HSA-3247509 Mitotic G1-G1/S phases R-HSA-453279 Chromatin organization R-HSA-4839726 Ubiquitin-dependent degradation of Cyclin D1 R-HSA-69229 Cyclin D associated events in G1 R-HSA-69231 G1 Phase R-HSA-69236 S Phase R-HSA-69242 Cell Cycle, Mitotic R-HSA-69278 Ubiquitin-dependent degradation of Cyclin D R-HSA-75815",GO:0000307 cyclin-dependent protein kinase holoenzyme complex 17420273 18827403 IDA GO:0000785 chromatin 18827403 IDA GO:0005634 nucleus 16109376 18827403 IDA GO:0005654 nucleoplasm TAS GO:0005667 transcription factor complex IEA GO:0005730 nucleolus 18827403 IDA GO:0005829 cytosol 18827403 IDA GO:0005829 cytosol TAS GO:0005923 bicellular tight junction IEA GO:0031965 nuclear membrane 18827403 IDA GO:0048471 perinuclear region of cytoplasm IEA,IMP 7603984 G1/S transition of mitotic cell cycle GO:0000082 IEA GO:0002088 lens development in camera-type eye IDA 8114739 protein phosphorylation GO:0006468 IEA GO:0007165 signal transduction IEA GO:0007623 circadian rhythm IMP 7603984 positive regulation of cell proliferation GO:0008284 IEA GO:0009636 response to toxic substance IEA GO:0010288 response to lead ion IMP 17420273 regulation of gene expression GO:0010468 IDA 19124461 positive regulation of G2/M transition of mitotic cell cycle GO:0010971 IEA GO:0031100 organ regeneration IEA GO:0033574 response to testosterone IGI 18291362 response to drug GO:0042493 IEA GO:0043065 positive regulation of apoptotic process IEA GO:0045727 positive regulation of translation TAS GO:0045787 positive regulation of cell cycle IEA GO:0045793 positive regulation of cell size IEA GO:0045859 regulation of protein kinase activity IMP 17420273 positive regulation of fibroblast proliferation GO:0048146 IEA GO:0051301 cell division IEA GO:0055093 response to hyperoxia IDA 19124461 negative regulation of cell cycle arrest GO:0071157,cyclin-dependent protein serine/threonine kinase activity GO:0004693 8114739 IDA protein binding GO:0005515 7568034 8078588 8259215 8741839 8756624 9106657 9150368 9529249 11896535 11900540 15107404 15232106 15558030 16169070 16189514 16326706 16962592 17053782 17517622 17909018 17955473 19447967 21242975 21516116 21871133 21900206 21988832 22094256 22939624 23455922 23602568 24189400 24218572 24855949 25036637 25241761 25416956 26496610 IPI ATP binding GO:0005524 IEA cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 TAS cyclin binding GO:0030332 19124461 IPI protein complex binding GO:0032403 IEA,Cell cycle - Homo sapiens (human) hsa04110 p53 signaling pathway - Homo sapiens (human) hsa04115 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Tight junction - Homo sapiens (human) hsa04530 T cell receptor signaling pathway - Homo sapiens (human) hsa04660 Hepatitis B - Homo sapiens (human) hsa05161 Measles - Homo sapiens (human) hsa05162 HTLV-I infection - Homo sapiens (human) hsa05166 Pathways in cancer - Homo sapiens (human) hsa05200 Viral carcinogenesis - Homo sapiens (human) hsa05203 Pancreatic cancer - Homo sapiens (human) hsa05212 Glioma - Homo sapiens (human) hsa05214 Melanoma - Homo sapiens (human) hsa05218 Bladder cancer - Homo sapiens (human) hsa05219 Chronic myeloid leukemia - Homo sapiens (human) hsa05220 Small cell lung cancer - Homo sapiens (human) hsa05222 Non-small cell lung cancer - Homo sapiens (human) hsa05223,chemicalprobes.org PD0332991,Q00534,Cyclin-dependent kinase 6,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,1021,CDK6,"R-HSA-1640170 Cell Cycle R-HSA-2262752 Cellular responses to stress R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559583 Cellular Senescence R-HSA-2559585 Oncogene Induced Senescence R-HSA-453279 Mitotic G1-G1/S phases R-HSA-69231 Cyclin D associated events in G1 R-HSA-69236 G1 Phase R-HSA-69278 Cell Cycle, Mitotic",cyclin-dependent protein kinase holoenzyme complex GO:0000307 IDA 17420273 ruffle GO:0001726 IDA 10205165 nucleus GO:0005634 IDA 14985467 nucleoplasm GO:0005654 IDA cytoplasm GO:0005737 IDA 14985467 centrosome GO:0005813 IDA 23918663 cytosol GO:0005829 TAS,16294322 TAS GO:0000082 G1/S transition of mitotic cell cycle 10205165 IDA GO:0001954 positive regulation of cell-matrix adhesion 20668294 IDA GO:0003323 type B pancreatic cell development 8114739 IDA GO:0006468 protein phosphorylation 16294322 TAS GO:0007050 cell cycle arrest IEA GO:0007219 Notch signaling pathway 16294322 TAS GO:0008285 negative regulation of cell proliferation 16548883 IEP GO:0009615 response to virus 15254224 IDA GO:0010468 regulation of gene expression 17420273 IMP GO:0010468 regulation of gene expression IEA GO:0010628 positive regulation of gene expression 16767702 ISS GO:0014002 astrocyte development 21319271 ISS GO:0021542 dentate gyrus development 21319271 ISS GO:0021670 lateral ventricle development IEA GO:0033077 T cell differentiation in thymus 12861051 IMP GO:0042063 gliogenesis 12861051 IMP GO:0043697 cell dedifferentiation 16294322 TAS GO:0045596 negative regulation of cell differentiation 17431401 IDA GO:0045638 negative regulation of myeloid cell differentiation 12833137 IMP GO:0045646 regulation of erythrocyte differentiation 15254224 IDA GO:0045668 negative regulation of osteoblast differentiation 14985467 IDA GO:0045786 negative regulation of cell cycle 17420273 IMP GO:0048146 positive regulation of fibroblast proliferation 21319271 ISS GO:0048699 generation of neurons 14985467 IMP GO:0050680 negative regulation of epithelial cell proliferation IEA GO:0051301 cell division IEA GO:0060218 hematopoietic stem cell differentiation 16767702 ISS GO:2000145 regulation of cell motility 17420273 IDA GO:2000773 negative regulation of cellular senescence,cyclin-dependent protein serine/threonine kinase activity 8114739 GO:0004693 IDA protein binding 8001816 8078588 8741839 8840966 9150368 9751050 15232106 17431401 17517622 17909018 17955473 18394558 21516116 22094256 22939624 23602568 24855949 25036637 25241761 25416956 GO:0005515 IPI ATP binding 9751050 GO:0005524 IDA cyclin binding 8114739 GO:0030332 IPI,Cell cycle - Homo sapiens (human) hsa04110 p53 signaling pathway - Homo sapiens (human) hsa04115 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Hepatitis B - Homo sapiens (human) hsa05161 Measles - Homo sapiens (human) hsa05162 Pathways in cancer - Homo sapiens (human) hsa05200 Viral carcinogenesis - Homo sapiens (human) hsa05203 MicroRNAs in cancer - Homo sapiens (human) hsa05206 Pancreatic cancer - Homo sapiens (human) hsa05212 Glioma - Homo sapiens (human) hsa05214 Melanoma - Homo sapiens (human) hsa05218 Chronic myeloid leukemia - Homo sapiens (human) hsa05220 Small cell lung cancer - Homo sapiens (human) hsa05222 Non-small cell lung cancer - Homo sapiens (human) hsa05223,chemicalprobes.org THZ1,P50613,Cyclin-dependent kinase 7,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,1022,CDK7,"Global Genomic NER (GG-NER) R-HSA-109970 Formation of transcription-coupled NER (TC-NER) repair complex R-HSA-110302 Dual incision reaction in TC-NER R-HSA-110304 Formation of RNA Pol II elongation complex R-HSA-112382 Formation of the Early Elongation Complex R-HSA-113418 HIV Life Cycle R-HSA-162587 Late Phase of HIV Life Cycle R-HSA-162599 HIV Infection R-HSA-162906 Cell Cycle R-HSA-1640170 Disease R-HSA-1643685 Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167152 Formation of the HIV-1 Early Elongation Complex R-HSA-167158 RNA Pol II CTD phosphorylation and interaction with CE R-HSA-167160 HIV Transcription Initiation R-HSA-167161 RNA Polymerase II HIV Promoter Escape R-HSA-167162 HIV Transcription Elongation R-HSA-167169 Transcription of the HIV genome R-HSA-167172 Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167200 Tat-mediated elongation of the HIV-1 transcript R-HSA-167246 Epigenetic regulation of gene expression R-HSA-212165 NoRC negatively regulates rRNA expression R-HSA-427413 Mitotic G2-G2/M phases R-HSA-453274 Mitotic G1-G1/S phases R-HSA-453279 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-504046 Negative epigenetic regulation of rRNA expression R-HSA-5250941 Infectious disease R-HSA-5663205 RNA Polymerase II Pre-transcription Events R-HSA-674695 Cyclin E associated events during G1/S transition R-HSA-69202 G1/S Transition R-HSA-69206 Cyclin D associated events in G1 R-HSA-69231 G1 Phase R-HSA-69236 S Phase R-HSA-69242 Cyclin A/B1 associated events during G2/M transition R-HSA-69273 G2/M Transition R-HSA-69275 Cell Cycle, Mitotic R-HSA-69278 Cyclin A:Cdk2-associated events at S phase entry R-HSA-69656 mRNA Capping R-HSA-72086 RNA Polymerase I Transcription Initiation R-HSA-73762 RNA Polymerase I Promoter Escape R-HSA-73772 RNA Polymerase II Promoter Escape R-HSA-73776 RNA Polymerase I Chain Elongation R-HSA-73777 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-73779 RNA Polymerase I Promoter Clearance R-HSA-73854 RNA Polymerase II Transcription R-HSA-73857 RNA Polymerase I Transcription Termination R-HSA-73863 RNA Polymerase I Transcription R-HSA-73864 Nucleotide Excision Repair R-HSA-73885 DNA Repair R-HSA-73894 Formation of incision complex in GG-NER R-HSA-73935 Transcription-coupled NER (TC-NER) R-HSA-73937 Dual incision reaction in GG-NER R-HSA-73941 Transcription R-HSA-74159 Gene Expression R-HSA-74160 RNA Polymerase II Transcription Initiation R-HSA-75953 RNA Polymerase II Transcription Elongation R-HSA-75955 RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-76042 RNA Pol II CTD phosphorylation and interaction with CE R-HSA-77075",IDA 16109376 nucleus GO:0005634 TAS GO:0005654 nucleoplasm IDA 9852112 holo TFIIH complex GO:0005675 IDA GO:0005737 cytoplasm IDA GO:0005739 mitochondrion IEA GO:0048471 perinuclear region of cytoplasm,"regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 7533895 TAS G1/S transition of mitotic cell cycle GO:0000082 TAS G2/M transition of mitotic cell cycle GO:0000086 TAS transcription-coupled nucleotide-excision repair GO:0006283 TAS nucleotide-excision repair, preincision complex assembly GO:0006294 TAS transcription initiation from RNA polymerase I promoter GO:0006361 TAS transcription elongation from RNA polymerase I promoter GO:0006362 TAS termination of RNA polymerase I transcription GO:0006363 TAS transcription from RNA polymerase II promoter GO:0006366 9852112 IDA transcription from RNA polymerase II promoter GO:0006366 TAS transcription initiation from RNA polymerase II promoter GO:0006367 TAS transcription elongation from RNA polymerase II promoter GO:0006368 TAS 7-methylguanosine mRNA capping GO:0006370 TAS protein phosphorylation GO:0006468 IEA cell cycle arrest GO:0007050 15876871 TAS cell proliferation GO:0008283 7533895 TAS androgen receptor signaling pathway GO:0030521 15572661 NAS snRNA transcription from RNA polymerase II promoter GO:0042795 TAS positive regulation of transcription, DNA-templated GO:0045893 15572661 NAS positive regulation of transcription from RNA polymerase II promoter GO:0045944 8692841 IDA cell division GO:0051301 IEA",15572661 GO:0003713 transcription coactivator activity NAS 7533895 GO:0004672 protein kinase activity TAS GO:0004674 protein serine/threonine kinase activity TAS GO:0004693 cyclin-dependent protein serine/threonine kinase activity IEA 23397142 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA 10801852 GO:0008022 protein C-terminus binding IPI 9852112 GO:0008094 DNA-dependent ATPase activity IDA 9852112 12721286 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity IDA GO:0016301 kinase activity TAS 15572661 GO:0050681 androgen receptor binding NAS,hsa03022 Basal transcription factors - Homo sapiens (human) hsa03420 Nucleotide excision repair - Homo sapiens (human) hsa04110 Cell cycle - Homo sapiens (human),chemicalprobes.org Selumetinib,Q02750,Dual specificity mitogen-activated protein kinase kinase 1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,5604,MP2K1,"MAPK3 (ERK1) activation R-HSA-110056 IRS-mediated signalling R-HSA-112399 RAF-independent MAPK1/3 activation R-HSA-112409 SOS-mediated signalling R-HSA-112412 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 SHC1 events in ERBB2 signaling R-HSA-1250196 SHC1 events in ERBB4 signaling R-HSA-1250347 Developmental Biology R-HSA-1266738 Cytokine Signaling in Immune system R-HSA-1280215 Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 Activated TLR4 signalling R-HSA-166054 MyD88:Mal cascade initiated on plasma membrane R-HSA-166058 MyD88-independent TLR3/TLR4 cascade R-HSA-166166 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168180 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Toll-Like Receptors Cascades R-HSA-168898 Prolonged ERK activation events R-HSA-169893 Frs2-mediated activation R-HSA-170968 ARMS-mediated activation R-HSA-170984 Signaling by EGFR R-HSA-177929 GRB2 events in EGFR signaling R-HSA-179812 SHC1 events in EGFR signaling R-HSA-180336 Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signalling to p38 via RIT and RIN R-HSA-187706 Signaling by FGFR R-HSA-190236 Signaling by VEGF R-HSA-194138 GRB2 events in ERBB2 signaling R-HSA-1963640 DAP12 interactions R-HSA-2172127 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Signaling by Leptin R-HSA-2586552 FCERI mediated MAPK activation R-HSA-2871796 Signaling by GPCR R-HSA-372790 L1CAM interactions R-HSA-373760 NCAM signaling for neurite out-growth R-HSA-375165 Axon guidance R-HSA-422475 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signal transduction by L1 R-HSA-445144 Interleukin-1 signaling R-HSA-446652 Signaling by Interleukins R-HSA-449147 MAP kinase activation in TLR cascade R-HSA-450294 Interleukin-2 signaling R-HSA-451927 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 Uptake and function of anthrax toxins R-HSA-5210891 VEGFR2 mediated cell proliferation R-HSA-5218921 Uptake and actions of bacterial toxins R-HSA-5339562 Downstream signaling of activated FGFR1 R-HSA-5654687 FRS-mediated FGFR1 signaling R-HSA-5654693 Downstream signaling of activated FGFR2 R-HSA-5654696 FRS-mediated FGFR2 signaling R-HSA-5654700 FRS-mediated FGFR3 signaling R-HSA-5654706 Downstream signaling of activated FGFR3 R-HSA-5654708 FRS-mediated FGFR4 signaling R-HSA-5654712 Downstream signaling of activated FGFR4 R-HSA-5654716 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 Infectious disease R-HSA-5663205 RAF activation R-HSA-5673000 RAF/MAP kinase cascade R-HSA-5673001 MAP2K and MAPK activation R-HSA-5674135 Negative feedback regulation of MAPK pathway R-HSA-5674499 Negative regulation of MAPK pathway R-HSA-5675221 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 Interleukin receptor SHC signaling R-HSA-912526 TRIF-mediated TLR3/TLR4 signaling R-HSA-937061 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 MyD88 dependent cascade initiated on endosome R-HSA-975155 MyD88 cascade initiated on plasma membrane R-HSA-975871",GO:0005634 nucleus 19565474 TAS GO:0005737 cytoplasm IDA GO:0005739 mitochondrion 19565474 TAS GO:0005769 early endosome 19565474 TAS GO:0005770 late endosome 19565474 TAS GO:0005783 endoplasmic reticulum 22572157 IDA GO:0005794 Golgi apparatus 19565474 TAS GO:0005815 microtubule organizing center IEA GO:0005829 cytosol 19565474 TAS GO:0005886 plasma membrane IDA GO:0005925 focal adhesion 19565474 TAS GO:0070062 extracellular exosome 23376485 IDA,"TAS GO:0000165 MAPK cascade 10644344 IDA GO:0000187 activation of MAPK activity 19565474 TAS GO:0000187 activation of MAPK activity 10912793 TAS GO:0006928 movement of cell or subcellular component 10570282 TAS GO:0006935 chemotaxis 9765203 IMP GO:0007050 cell cycle arrest 10570282 TAS GO:0007165 signal transduction IEA GO:0007507 heart development 9765203 IDA GO:0008285 negative regulation of cell proliferation 15155804 IMP GO:0010628 positive regulation of gene expression 23626836 IGI GO:0010629 negative regulation of gene expression IEA GO:0018108 peptidyl-tyrosine phosphorylation IEA GO:0021697 cerebellar cortex formation IEA GO:0030182 neuron differentiation IEA GO:0030216 keratinocyte differentiation IEA GO:0030878 thyroid gland development 19565474 TAS GO:0032872 regulation of stress-activated MAPK cascade TAS GO:0035897 proteolysis in other organism 24375836 IMP GO:0045893 positive regulation of transcription, DNA-templated IEA GO:0048538 thymus development IEA GO:0048679 regulation of axon regeneration IEA GO:0048870 cell motility IEA GO:0050772 positive regulation of axonogenesis IEA GO:0060020 Bergmann glial cell differentiation IEA GO:0060324 face development IEA GO:0060440 trachea formation IEA GO:0060502 epithelial cell proliferation involved in lung morphogenesis IEA GO:0060674 placenta blood vessel development IEA GO:0060711 labyrinthine layer development IEA GO:0070371 ERK1 and ERK2 cascade 24375836 IMP GO:0070374 positive regulation of ERK1 and ERK2 cascade 8388392 IDA GO:0071902 positive regulation of protein serine/threonine kinase activity 19565474 TAS GO:0090170 regulation of Golgi inheritance 9765203 IMP GO:0090398 cellular senescence 22020285 IGI GO:0098779 mitophagy in response to mitochondrial depolarization 24375836 IMP GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA 19565474 TAS GO:2000641 regulation of early endosome to late endosome transport",protein kinase activity GO:0004672 10570282 TAS protein serine/threonine kinase activity GO:0004674 TAS receptor signaling protein serine/threonine kinase activity GO:0004702 IBA MAP kinase kinase activity GO:0004708 8388392 IDA protein serine/threonine/tyrosine kinase activity GO:0004712 19565474 TAS protein tyrosine kinase activity GO:0004713 IEA receptor signaling protein tyrosine phosphatase activity GO:0004728 IEA protein binding GO:0005515 15299019 17110930 17255949 17979178 18329369 19197339 20679487 22752157 23241949 24211253 24746704 25155755 25416956 25600339 26496610 IPI ATP binding GO:0005524 IEA protein C-terminus binding GO:0008022 22572157 IDA protein kinase binding GO:0019901 22065579 IPI protein serine/threonine kinase activator activity GO:0043539 8388392 IDA protein N-terminus binding GO:0047485 22572157 IDA,hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04071 Sphingolipid signaling pathway - Homo sapiens (human) hsa04114 Oocyte meiosis - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) hsa04320 Dorso-ventral axis formation - Homo sapiens (human) hsa04370 VEGF signaling pathway - Homo sapiens (human) hsa04380 Osteoclast differentiation - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04540 Gap junction - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04660 T cell receptor signaling pathway - Homo sapiens (human) hsa04662 B cell receptor signaling pathway - Homo sapiens (human) hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04668 TNF signaling pathway - Homo sapiens (human) hsa04720 Long-term potentiation - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human) hsa04726 Serotonergic synapse - Homo sapiens (human) hsa04730 Long-term depression - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04910 Insulin signaling pathway - Homo sapiens (human) hsa04912 GnRH signaling pathway - Homo sapiens (human) hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04915 Estrogen signaling pathway - Homo sapiens (human) hsa04916 Melanogenesis - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04921 Oxytocin signaling pathway - Homo sapiens (human) hsa05020 Prion diseases - Homo sapiens (human) hsa05034 Alcoholism - Homo sapiens (human) hsa05161 Hepatitis B - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05210 Colorectal cancer - Homo sapiens (human) hsa05211 Renal cell carcinoma - Homo sapiens (human) hsa05212 Pancreatic cancer - Homo sapiens (human) hsa05213 Endometrial cancer - Homo sapiens (human) hsa05214 Glioma - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05216 Thyroid cancer - Homo sapiens (human) hsa05218 Melanoma - Homo sapiens (human) hsa05219 Bladder cancer - Homo sapiens (human) hsa05220 Chronic myeloid leukemia - Homo sapiens (human) hsa05221 Acute myeloid leukemia - Homo sapiens (human) hsa05223 Non-small cell lung cancer - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human) hsa05231 Choline metabolism in cancer - Homo sapiens (human),chemicalprobes.org BIX-02188,Q13163,Dual specificity mitogen-activated protein kinase kinase 5,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,5607,MP2K5,Signal Transduction R-HSA-162582 Signalling by NGF R-HSA-166520 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERK5 R-HSA-198765,GO:0005634 nucleus IEA GO:0005737 cytoplasm IBA GO:0005819 spindle IEA GO:0005829 cytosol IEA,negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS activation of MAPK activity GO:0000187 20551324 ISS signal transduction GO:0007165 7759517 TAS heart development GO:0007507 IEA peptidyl-tyrosine phosphorylation GO:0018108 IEA positive regulation of cell growth GO:0030307 IEA negative regulation of NF-kappaB transcription factor activity GO:0032088 20551324 ISS negative regulation of heterotypic cell-cell adhesion GO:0034115 20551324 ISS negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 20551324 ISS negative regulation of interleukin-8 biosynthetic process GO:0045415 20551324 ISS positive regulation of transcription from RNA polymerase II promoter GO:0045944 ISS positive regulation of epithelial cell proliferation GO:0050679 IEA positive regulation of protein metabolic process GO:0051247 ISS negative regulation of response to cytokine stimulus GO:0060761 20551324 ISS ERK5 cascade GO:0070375 IEA cellular response to growth factor stimulus GO:0071363 20551324 ISS cellular response to laminar fluid shear stress GO:0071499 20551324 TAS negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 20551324 ISS negative regulation of chemokine (C-X-C motif) ligand 2 production GO:2000342 20551324 ISS negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 20551324 ISS,protein kinase activity GO:0004672 7759517 TAS receptor signaling protein serine/threonine kinase activity GO:0004702 IBA protein tyrosine kinase activity GO:0004713 IEA protein binding GO:0005515 7759517 14743216 17474147 18588859 25241761 IPI ATP binding GO:0005524 IEA metal ion binding GO:0046872 IEA,hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04540 Gap junction - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa04921 Oxytocin signaling pathway - Homo sapiens (human),chemicalprobes.org MPS1-IN-1,P33981,Dual specificity protein kinase TTK,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,7272,TTK,,spindle GO:0005819 10366450 TAS membrane GO:0016020 19946888 IDA,spindle organization TAS 10366450 GO:0007051 mitotic spindle organization TAS 7737118 GO:0007052 mitotic spindle assembly checkpoint TAS 10366450 GO:0007094 positive regulation of cell proliferation TAS 1639825 GO:0008284 positive regulation of pathway-restricted SMAD protein phosphorylation TAS 19018011 GO:0010862 peptidyl-tyrosine phosphorylation IEA GO:0018108 chromosome separation IEA GO:0051304,GO:0004674 protein serine/threonine kinase activity IEA GO:0004712 protein serine/threonine/tyrosine kinase activity IEA GO:0004713 protein tyrosine kinase activity IEA GO:0005515 protein binding 19273613 IPI GO:0005524 ATP binding IEA,Cell cycle - Homo sapiens (human) hsa04110,chemicalprobes.org AZ191,Q9Y463,Dual specificity tyrosine-phosphorylation-regulated kinase 1B,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,9149,DYR1B,,nucleus GO:0005634 IEA,"protein phosphorylation GO:0006468 11980910 IDA myoblast fusion GO:0007520 IEA peptidyl-tyrosine phosphorylation GO:0018108 IEA positive regulation of transcription, DNA-templated GO:0045893 11980910 IDA adipose tissue development GO:0060612 24827035 IMP",11980910 IDA GO:0003713 transcription coactivator activity 11980910 IDA GO:0004672 protein kinase activity IEA GO:0004674 protein serine/threonine kinase activity IEA GO:0004712 protein serine/threonine/tyrosine kinase activity IEA GO:0004713 protein tyrosine kinase activity 11980910 14500717 14593110 20940704 23602568 IPI GO:0005515 protein binding IEA GO:0005524 ATP binding,,chemicalprobes.org Afatinib,P00533,Epidermal growth factor receptor erbB1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,1956,EGFR,"IRS-mediated signalling R-HSA-112399 SOS-mediated signalling R-HSA-112412 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 Signaling by ERBB2 R-HSA-1227986 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236382 Signaling by ERBB4 R-HSA-1236394 SHC1 events in ERBB2 signaling R-HSA-1250196 PI3K events in ERBB4 signaling R-HSA-1250342 SHC1 events in ERBB4 signaling R-HSA-1250347 PLCG1 events in ERBB2 signaling R-HSA-1251932 PIP3 activates AKT signaling R-HSA-1257604 Developmental Biology R-HSA-1266738 Cytokine Signaling in Immune system R-HSA-1280215 Adaptive Immune System R-HSA-1280218 Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Signaling by EGFR in Cancer R-HSA-1643713 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Prolonged ERK activation events R-HSA-169893 Frs2-mediated activation R-HSA-170968 ARMS-mediated activation R-HSA-170984 Signaling by EGFR R-HSA-177929 GRB2 events in EGFR signaling R-HSA-179812 GAB1 signalosome R-HSA-180292 SHC1 events in EGFR signaling R-HSA-180336 EGFR downregulation R-HSA-182971 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signalling to p38 via RIT and RIN R-HSA-187706 Signaling by FGFR R-HSA-190236 Signaling by VEGF R-HSA-194138 GRB2 events in ERBB2 signaling R-HSA-1963640 PI3K events in ERBB2 signaling R-HSA-1963642 PI3K/AKT activation R-HSA-198203 EGFR interacts with phospholipase C-gamma R-HSA-212718 DAP12 interactions R-HSA-2172127 EGFR Transactivation by Gastrin R-HSA-2179392 PI3K/AKT Signaling in Cancer R-HSA-2219528 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Signaling by Leptin R-HSA-2586552 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 FCERI mediated MAPK activation R-HSA-2871796 Signaling by GPCR R-HSA-372790 L1CAM interactions R-HSA-373760 NCAM signaling for neurite out-growth R-HSA-375165 Axon guidance R-HSA-422475 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signal transduction by L1 R-HSA-445144 Signaling by Interleukins R-HSA-449147 Interleukin-2 signaling R-HSA-451927 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 VEGFR2 mediated cell proliferation R-HSA-5218921 Constitutive Signaling by EGFRvIII R-HSA-5637810 Signaling by EGFRvIII in Cancer R-HSA-5637812 Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5637815 Signaling by Overexpressed Wild-Type EGFR in Cancer R-HSA-5638302 Inhibition of Signaling by Overexpressed EGFR R-HSA-5638303 Downstream signaling of activated FGFR1 R-HSA-5654687 PI-3K cascade:FGFR1 R-HSA-5654689 FRS-mediated FGFR1 signaling R-HSA-5654693 PI-3K cascade:FGFR2 R-HSA-5654695 Downstream signaling of activated FGFR2 R-HSA-5654696 FRS-mediated FGFR2 signaling R-HSA-5654700 FRS-mediated FGFR3 signaling R-HSA-5654706 Downstream signaling of activated FGFR3 R-HSA-5654708 PI-3K cascade:FGFR3 R-HSA-5654710 FRS-mediated FGFR4 signaling R-HSA-5654712 Downstream signaling of activated FGFR4 R-HSA-5654716 PI-3K cascade:FGFR4 R-HSA-5654720 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 Diseases of signal transduction R-HSA-5663202 RAF/MAP kinase cascade R-HSA-5673001 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 Interleukin receptor SHC signaling R-HSA-912526 Signaling by the B Cell Receptor (BCR) R-HSA-983705","IEA GO:0000139 Golgi membrane 9103388 NAS GO:0005615 extracellular space 12828935 17115032 20551055 IDA GO:0005634 nucleus 7588596 12435727 IDA GO:0005737 cytoplasm 14702346 17182860 IDA GO:0005768 endosome IEA GO:0005789 endoplasmic reticulum membrane 15465819 IDA GO:0005886 plasma membrane TAS GO:0005886 plasma membrane 21423176 IDA GO:0005925 focal adhesion 25666625 IDA GO:0009986 cell surface 22719997 IDA GO:0010008 endosome membrane 12435727 IDA GO:0016020 membrane IEA GO:0016021 integral component of membrane 12646923 IDA GO:0016323 basolateral plasma membrane 14702346 TAS GO:0030122 colocalizes_with AP-2 adaptor complex 17714434 IDA GO:0031901 early endosome membrane IEA GO:0031965 nuclear membrane 23382219 IDA GO:0043235 receptor complex 12009895 IDA GO:0045121 membrane raft IEA GO:0048471 perinuclear region of cytoplasm ISS GO:0070435 Shc-EGFR complex 17714434 IDA GO:0097489 multivesicular body, internal vesicle lumen",GO:0000165 MAPK cascade TAS GO:0000186 activation of MAPKK activity IEA GO:0000902 cell morphogenesis IEA 12925580 GO:0001503 ossification NAS GO:0001892 embryonic placenta development IEA 20551055 GO:0001934 positive regulation of protein phosphorylation IDA GO:0001942 hair follicle development IEA 12828935 GO:0006950 response to stress NAS 10572067 GO:0007165 signal transduction IDA GO:0007165 signal transduction TAS 7736574 GO:0007166 cell surface receptor signaling pathway IDA 7736574 12435727 GO:0007173 epidermal growth factor receptor signaling pathway IDA GO:0007173 epidermal growth factor receptor signaling pathway TAS 12435727 GO:0007202 activation of phospholipase C activity TAS GO:0007435 salivary gland morphogenesis IEA GO:0007611 learning or memory ISS 17115032 GO:0008283 cell proliferation IDA 7736574 GO:0008284 positive regulation of cell proliferation IDA GO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS 12435727 GO:0016337 single organismal cell-cell adhesion IMP GO:0018108 peptidyl-tyrosine phosphorylation IEA GO:0021795 cerebral cortex cell migration IEA 15467833 GO:0030307 positive regulation of cell growth IDA 12435727 GO:0030335 positive regulation of cell migration IMP 18483258 GO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle IDA 20302655 GO:0035413 positive regulation of catenin import into nucleus IMP GO:0038128 ERBB2 signaling pathway TAS GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway TAS 17115032 GO:0042177 negative regulation of protein catabolic process IDA 15082764 GO:0042327 positive regulation of phosphorylation IDA 12435727 GO:0043006 activation of phospholipase A2 activity by calcium-mediated signaling TAS 18070883 GO:0043066 negative regulation of apoptotic process IMP 10572067 GO:0043406 positive regulation of MAP kinase activity IDA GO:0043547 positive regulation of GTPase activity IEA 12828935 GO:0045429 positive regulation of nitric oxide biosynthetic process IDA 17115032 GO:0045739 positive regulation of DNA repair IDA 17115032 GO:0045740 positive regulation of DNA replication IDA 20551055 GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 18070883 GO:0046777 protein autophosphorylation IMP GO:0046854 phosphatidylinositol phosphorylation IEA GO:0048015 phosphatidylinositol-mediated signaling TAS GO:0048146 positive regulation of fibroblast proliferation IEA GO:0048546 digestive tract morphogenesis IEA 10572067 GO:0050679 positive regulation of epithelial cell proliferation IDA 12435727 GO:0050730 regulation of peptidyl-tyrosine phosphorylation IMP 12828935 GO:0050999 regulation of nitric-oxide synthase activity IDA 12435727 GO:0051205 protein insertion into membrane TAS 17655843 GO:0051897 positive regulation of protein kinase B signaling IMP GO:0060571 morphogenesis of an epithelial fold IEA GO:0061029 eyelid development in camera-type eye IEA 18483258 GO:0070141 response to UV-A IDA 20551055 GO:0070374 positive regulation of ERK1 and ERK2 cascade IDA 21673316 GO:0070374 positive regulation of ERK1 and ERK2 cascade IMP GO:0071230 cellular response to amino acid stimulus IEA GO:0071364 cellular response to epidermal growth factor stimulus ISS 20551055 GO:0071392 cellular response to estradiol stimulus IDA 21673316 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA IMP GO:2000145 regulation of cell motility TAS,"chromatin binding IDA 20551055 GO:0003682 double-stranded DNA binding NAS 6325948 GO:0003690 MAP kinase kinase kinase activity NAS 15542601 GO:0004709 protein tyrosine kinase activity EXP 17349580 GO:0004713 protein tyrosine kinase activity IDA 17115032 17599051 GO:0004713 protein tyrosine kinase activity IMP 14702346 GO:0004713 protein tyrosine kinase activity TAS 16076471 GO:0004713 transmembrane receptor protein tyrosine kinase activity TAS GO:0004714 receptor signaling protein tyrosine kinase activity IEA GO:0004716 transmembrane signaling receptor activity IDA 7736574 GO:0004888 epidermal growth factor-activated receptor activity IDA 12435727 17115032 GO:0005006 epidermal growth factor-activated receptor activity NAS 2790960 6325948 GO:0005006 Ras guanyl-nucleotide exchange factor activity TAS GO:0005088 protein binding IPI 2176151 2790960 7518560 7542744 7657591 7685104 7693694 7797556 7993895 8034616 8305738 8621392 8887653 8940013 9020117 9050838 9355745 9419975 9544989 9852145 10026169 10229072 10572067 10805725 11279102 11853560 11896612 12070153 12297049 12297050 12577067 12620237 14568990 14679214 14960328 14966128 15225635 15590694 15657067 15962011 16273093 16499958 16516204 16799092 16843263 16914641 17115032 17126326 17182860 17284441 17403676 17599051 17909029 18046415 18273061 18455122 18602463 18824549 19172738 19509291 19602593 19650109 19798056 20029029 20403327 20551055 20562913 20624308 20935677 20946980 21258405 21266349 21278786 21278788 21349850 21376233 21439278 21706016 22439932 22939624 23178489 23178716 23397142 23436906 23520446 23597562 23764002 23799367 23866081 23912460 24034250 24076656 24135280 24189400 24557338 24658140 24780295 24947832 25036637 25241761 25311788 25594178 25666625 25796184 25873175 GO:0005515 ATP binding IEA GO:0005524 enzyme binding IPI 12009895 GO:0019899 protein phosphatase binding IPI 15899872 GO:0019903 contributes_to nitric-oxide synthase regulator activity IDA 12828935 GO:0030235 ubiquitin protein ligase binding IPI 23418353 GO:0031625 identical protein binding IPI 16777603 19563760 19650109 20029029 20359299 20946980 21278786 21480528 22232519 22579287 23374349 23436906 24135280 GO:0042802 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS GO:0046934 protein heterodimerization activity IDA 10572067 GO:0046982 actin filament binding IDA 14702346 GO:0051015",hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04144 Endocytosis - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04320 Dorso-ventral axis formation - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04520 Adherens junction - Homo sapiens (human) hsa04540 Gap junction - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04912 GnRH signaling pathway - Homo sapiens (human) hsa04915 Estrogen signaling pathway - Homo sapiens (human) hsa04921 Oxytocin signaling pathway - Homo sapiens (human) hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05212 Pancreatic cancer - Homo sapiens (human) hsa05213 Endometrial cancer - Homo sapiens (human) hsa05214 Glioma - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05218 Melanoma - Homo sapiens (human) hsa05219 Bladder cancer - Homo sapiens (human) hsa05223 Non-small cell lung cancer - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human) hsa05231 Choline metabolism in cancer - Homo sapiens (human),chemicalprobes.org DDR1-IN-1,Q08345,Epithelial discoidin domain-containing receptor 1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,780,DDR1,R-HSA-1474244 Extracellular matrix organization R-HSA-3000171 Non-integrin membrane-ECM interactions,16502470 GO:0005615 extracellular space IDA GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane IEA GO:0016323 basolateral plasma membrane IEA 23382219 GO:0043235 receptor complex IDA 19199708 23376485 GO:0070062 extracellular exosome IDA,"IEA GO:0001558 regulation of cell growth IEA GO:0001952 regulation of cell-matrix adhesion TAS 8302582 cell adhesion GO:0007155 IEA GO:0007566 embryo implantation IEA GO:0007595 lactation IEA GO:0008285 negative regulation of cell proliferation IMP 12065315 regulation of extracellular matrix disassembly GO:0010715 IMP 12065315 smooth muscle cell migration GO:0014909 TAS GO:0030198 extracellular matrix organization IEA GO:0031100 organ regeneration IDA 9659899 21044884 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IMP 12065315 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IDA 21044884 peptidyl-tyrosine autophosphorylation GO:0038083 IEA GO:0043583 ear development IEA GO:0043588 skin development IMP 12065315 wound healing, spreading of cells GO:0044319 IDA 9659899 protein autophosphorylation GO:0046777 IEA GO:0060444 branching involved in mammary gland duct morphogenesis IEA GO:0060749 mammary gland alveolus development IMP 12065315 smooth muscle cell-matrix adhesion GO:0061302",TAS 9659899 transmembrane receptor protein tyrosine kinase activity GO:0004714 IPI 16337946 18190796 protein binding GO:0005515 IDA 9659899 collagen binding GO:0005518 IMP 12065315 collagen binding GO:0005518 IEA GO:0005524 ATP binding IDA 9659899 21044884 protein tyrosine kinase collagen receptor activity GO:0038062 IEA GO:0046872 metal ion binding,,chemicalprobes.org BGJ-398,P11362,Fibroblast growth factor receptor 1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2260,FGFR1,"PI3K Cascade R-HSA-109704 IRS-mediated signalling R-HSA-112399 SOS-mediated signalling R-HSA-112412 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 Signaling by FGFR in disease R-HSA-1226099 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 SHC1 events in ERBB2 signaling R-HSA-1250196 PI3K events in ERBB4 signaling R-HSA-1250342 SHC1 events in ERBB4 signaling R-HSA-1250347 PIP3 activates AKT signaling R-HSA-1257604 Developmental Biology R-HSA-1266738 Cytokine Signaling in Immune system R-HSA-1280215 Adaptive Immune System R-HSA-1280218 Klotho-mediated ligand binding R-HSA-1307973 Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Prolonged ERK activation events R-HSA-169893 Frs2-mediated activation R-HSA-170968 ARMS-mediated activation R-HSA-170984 Signaling by EGFR R-HSA-177929 GRB2 events in EGFR signaling R-HSA-179812 GAB1 signalosome R-HSA-180292 SHC1 events in EGFR signaling R-HSA-180336 Signaling by FGFR1 amplification mutants R-HSA-1839120 Signaling by activated point mutants of FGFR1 R-HSA-1839122 FGFR1 mutant receptor activation R-HSA-1839124 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signalling to p38 via RIT and RIN R-HSA-187706 Signaling by FGFR R-HSA-190236 FGFR1 ligand binding and activation R-HSA-190242 FGFR1b ligand binding and activation R-HSA-190370 FGFR1c ligand binding and activation R-HSA-190373 FGFR1c and Klotho ligand binding and activation R-HSA-190374 Signaling by VEGF R-HSA-194138 GRB2 events in ERBB2 signaling R-HSA-1963640 PI3K events in ERBB2 signaling R-HSA-1963642 PI3K/AKT activation R-HSA-198203 DAP12 interactions R-HSA-2172127 PI3K/AKT Signaling in Cancer R-HSA-2219528 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Signaling by Leptin R-HSA-2586552 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 FCERI mediated MAPK activation R-HSA-2871796 Signaling by GPCR R-HSA-372790 L1CAM interactions R-HSA-373760 NCAM signaling for neurite out-growth R-HSA-375165 Axon guidance R-HSA-422475 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signal transduction by L1 R-HSA-445144 Signaling by Interleukins R-HSA-449147 Interleukin-2 signaling R-HSA-451927 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 VEGFR2 mediated cell proliferation R-HSA-5218921 Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 Downstream signaling of activated FGFR1 R-HSA-5654687 SHC-mediated cascade:FGFR1 R-HSA-5654688 PI-3K cascade:FGFR1 R-HSA-5654689 FRS-mediated FGFR1 signaling R-HSA-5654693 PI-3K cascade:FGFR2 R-HSA-5654695 Downstream signaling of activated FGFR2 R-HSA-5654696 FRS-mediated FGFR2 signaling R-HSA-5654700 FRS-mediated FGFR3 signaling R-HSA-5654706 Downstream signaling of activated FGFR3 R-HSA-5654708 PI-3K cascade:FGFR3 R-HSA-5654710 FRS-mediated FGFR4 signaling R-HSA-5654712 Downstream signaling of activated FGFR4 R-HSA-5654716 PI-3K cascade:FGFR4 R-HSA-5654720 Negative regulation of FGFR1 signaling R-HSA-5654726 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 Signaling by FGFR1 in disease R-HSA-5655302 Signaling by FGFR1 mutants R-HSA-5655311 Diseases of signal transduction R-HSA-5663202 RAF/MAP kinase cascade R-HSA-5673001 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 Interleukin receptor SHC signaling R-HSA-912526 Signaling by the B Cell Receptor (BCR) R-HSA-983705","1652059 NAS GO:0005576 extracellular region IEA GO:0005634 nucleus IEA GO:0005829 cytosol 18480409 IDA GO:0005886 plasma membrane TAS GO:0005886 plasma membrane 10918587 TAS GO:0005887 integral component of plasma membrane 1652059 1846977 2159626 NAS GO:0016021 integral component of membrane IEA GO:0016023 cytoplasmic, membrane-bounded vesicle 23382219 IDA GO:0043235 receptor complex","negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA MAPK cascade GO:0000165 TAS skeletal system development 7874169 GO:0001501 TAS angiogenesis GO:0001525 IEA ureteric bud development GO:0001657 IEA in utero embryonic development GO:0001701 IEA organ induction GO:0001759 IEA neuron migration 15863030 GO:0001764 TAS positive regulation of mesenchymal cell proliferation GO:0002053 IEA chondrocyte differentiation GO:0002062 IEA transcription, DNA-templated GO:0006351 IEA protein phosphorylation 1846977 2159626 GO:0006468 NAS sensory perception of sound GO:0007605 IEA positive regulation of cell proliferation 8663044 GO:0008284 IDA positive regulation of cell proliferation 8663044 GO:0008284 IGI positive regulation of cell proliferation 8622701 GO:0008284 IMP fibroblast growth factor receptor signaling pathway 8663044 GO:0008543 IDA fibroblast growth factor receptor signaling pathway 8663044 GO:0008543 IGI fibroblast growth factor receptor signaling pathway 10830168 GO:0008543 IPI fibroblast growth factor receptor signaling pathway GO:0008543 TAS positive regulation of phospholipase activity 12141425 GO:0010518 TAS positive regulation of phospholipase C activity 18480409 GO:0010863 IDA positive regulation of neuron projection development GO:0010976 IEA regulation of phosphatidylinositol 3-kinase signaling GO:0014066 TAS positive regulation of phosphatidylinositol 3-kinase signaling 15863030 GO:0014068 TAS cell migration 15863030 GO:0016477 TAS peptidyl-tyrosine phosphorylation 8622701 18480409 GO:0018108 IDA stem cell population maintenance GO:0019827 IEA motogenic signaling involved in postnatal olfactory bulb interneuron migration GO:0021837 IEA ventricular zone neuroblast division GO:0021847 IEA embryonic limb morphogenesis GO:0030326 IEA midbrain development GO:0030901 IEA neuron projection development GO:0031175 IEA fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development GO:0035607 IEA phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IEA inner ear morphogenesis GO:0042472 IEA outer ear morphogenesis GO:0042473 IEA middle ear morphogenesis GO:0042474 IEA chordate embryonic development 15863030 GO:0043009 TAS positive regulation of MAP kinase activity 8622701 18480409 GO:0043406 IDA positive regulation of MAPK cascade 8622701 GO:0043410 IMP positive regulation of GTPase activity GO:0043547 IEA regulation of cell differentiation 12141425 GO:0045595 TAS positive regulation of neuron differentiation 8622701 GO:0045666 IMP negative regulation of osteoblast differentiation GO:0045668 IEA positive regulation of cell cycle GO:0045787 IEA protein autophosphorylation 8622701 GO:0046777 IDA phosphatidylinositol phosphorylation GO:0046854 IEA phosphatidylinositol-mediated signaling 12141425 GO:0048015 TAS paraxial mesoderm development GO:0048339 IEA regulation of lateral mesodermal cell fate specification GO:0048378 IEA cell maturation GO:0048469 IEA skeletal system morphogenesis 15863030 GO:0048705 TAS mesenchymal cell differentiation GO:0048762 IEA regulation of sensory perception of pain GO:0051930 IEA positive regulation of cardiac muscle cell proliferation GO:0060045 IEA auditory receptor cell development GO:0060117 IEA branching involved in salivary gland morphogenesis GO:0060445 IEA lung-associated mesenchyme development GO:0060484 IEA regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 IEA positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 IEA positive regulation of endothelial cell chemotaxis to fibroblast growth factor 21885851 GO:2000546 IDA regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 IEA","glycoprotein binding IEA GO:0001948 protein tyrosine kinase activity IDA 8622701 GO:0004713 protein tyrosine kinase activity TAS GO:0004713 fibroblast growth factor-activated receptor activity IDA 18480409 20133753 GO:0005007 fibroblast growth factor-activated receptor activity TAS 2167437 GO:0005007 Ras guanyl-nucleotide exchange factor activity TAS GO:0005088 protein binding IPI 1656221 8321198 8753773 9660748 10464310 10490103 10830168 11030354 11401320 18412956 18441324 19665973 19696444 20932831 21765395 22035699 22751148 23597563 25241761 26267536 GO:0005515 ATP binding IEA GO:0005524 heparin binding IDA 18480409 GO:0008201 1-phosphatidylinositol-3-kinase activity TAS GO:0016303 fibroblast growth factor binding IDA 8663044 18480409 GO:0017134 protein complex binding IEA GO:0032403 identical protein binding IPI 19696444 GO:0042802 protein homodimerization activity IPI 20133753 GO:0042803 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS GO:0046934 cell adhesion molecule binding IEA GO:0050839",hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04520 Adherens junction - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05218 Melanoma - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human),chemicalprobes.org BGJ-398,P21802,Fibroblast growth factor receptor 2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2263,FGFR2,"R-HSA-109704 PI3K Cascade R-HSA-112399 IRS-mediated signalling R-HSA-112412 SOS-mediated signalling R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1226099 Signaling by FGFR in disease R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250196 SHC1 events in ERBB2 signaling R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1250347 SHC1 events in ERBB4 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1266738 Developmental Biology R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-1433557 Signaling by SCF-KIT R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-166520 Signalling by NGF R-HSA-167044 Signalling to RAS R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-169893 Prolonged ERK activation events R-HSA-170968 Frs2-mediated activation R-HSA-170984 ARMS-mediated activation R-HSA-177929 Signaling by EGFR R-HSA-179812 GRB2 events in EGFR signaling R-HSA-180292 GAB1 signalosome R-HSA-180336 SHC1 events in EGFR signaling R-HSA-1839126 FGFR2 mutant receptor activation R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-187687 Signalling to ERKs R-HSA-187706 Signalling to p38 via RIT and RIN R-HSA-190236 Signaling by FGFR R-HSA-190241 FGFR2 ligand binding and activation R-HSA-190375 FGFR2c ligand binding and activation R-HSA-190377 FGFR2b ligand binding and activation R-HSA-194138 Signaling by VEGF R-HSA-1963640 GRB2 events in ERBB2 signaling R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-2023837 Signaling by FGFR2 amplification mutants R-HSA-2033519 Activated point mutants of FGFR2 R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2586552 Signaling by Leptin R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-372790 Signaling by GPCR R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-422475 Axon guidance R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-5654221 Phospholipase C-mediated cascade; FGFR2 R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654699 SHC-mediated cascade:FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654727 Negative regulation of FGFR2 signaling R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5655253 Signaling by FGFR2 in disease R-HSA-5655304 Signaling by FGFR2 mutants R-HSA-5655324 Signaling by FGFR4 mutants R-HSA-5663202 Diseases of signal transduction R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5683057 MAPK family signaling cascades R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-912526 Interleukin receptor SHC signaling R-HSA-983705 Signaling by the B Cell Receptor (BCR)","extracellular region GO:0005576 IEA nucleus GO:0005634 16597614 17471512 IDA nucleoplasm GO:0005654 IDA cytoplasm GO:0005737 16597614 17471512 IDA Golgi apparatus GO:0005794 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 15629145 16844695 IDA cell cortex GO:0005938 17471512 IDA cell surface GO:0009986 16597614 IDA membrane GO:0016020 8676562 NAS integral component of membrane GO:0016021 1697263 NAS cytoplasmic, membrane-bounded vesicle GO:0016023 IEA extracellular matrix GO:0031012 17959718 IDA colocalizes_with intracellular membrane-bounded organelle GO:0043231 IDA excitatory synapse GO:0060076 ISS",GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS GO:0000165 MAPK cascade TAS GO:0001525 angiogenesis ISS GO:0001657 ureteric bud development ISS GO:0001701 in utero embryonic development ISS GO:0001837 epithelial to mesenchymal transition IEA GO:0002053 positive regulation of mesenchymal cell proliferation ISS GO:0003148 outflow tract septum morphogenesis ISS GO:0003149 membranous septum morphogenesis ISS GO:0006915 apoptotic process IEA GO:0007267 cell-cell signaling ISS GO:0007409 axonogenesis ISS 8663044 GO:0008284 positive regulation of cell proliferation IDA 8663044 GO:0008284 positive regulation of cell proliferation IGI 15629145 GO:0008284 positive regulation of cell proliferation IMP 8663044 15629145 GO:0008543 fibroblast growth factor receptor signaling pathway IDA 8663044 GO:0008543 fibroblast growth factor receptor signaling pathway IGI 10830168 GO:0008543 fibroblast growth factor receptor signaling pathway IPI GO:0008543 fibroblast growth factor receptor signaling pathway TAS GO:0008589 regulation of smoothened signaling pathway ISS GO:0009791 post-embryonic development ISS GO:0009880 embryonic pattern specification ISS GO:0009887 organ morphogenesis ISS GO:0010453 regulation of cell fate commitment ISS 16844695 GO:0010518 positive regulation of phospholipase activity IMP GO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS GO:0016331 morphogenesis of embryonic epithelium ISS 15629145 16844695 GO:0018108 peptidyl-tyrosine phosphorylation IDA GO:0021769 orbitofrontal cortex development ISS GO:0021847 ventricular zone neuroblast division ISS GO:0021860 pyramidal neuron development ISS GO:0022612 gland morphogenesis ISS GO:0030177 positive regulation of Wnt signaling pathway ISS GO:0030282 bone mineralization ISS GO:0030324 lung development ISS GO:0030855 epithelial cell differentiation ISS GO:0030901 midbrain development ISS GO:0030916 otic vesicle formation ISS GO:0031069 hair follicle morphogenesis ISS GO:0032808 lacrimal gland development ISS 15190072 GO:0033688 regulation of osteoblast proliferation TAS GO:0035264 multicellular organism growth ISS GO:0035265 organ growth ISS GO:0035602 fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow ISS GO:0035603 fibroblast growth factor receptor signaling pathway involved in hemopoiesis ISS GO:0035604 fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow ISS GO:0035607 fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development ISS GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA GO:0040014 regulation of multicellular organism growth ISS GO:0040036 regulation of fibroblast growth factor receptor signaling pathway ISS GO:0042472 inner ear morphogenesis ISS GO:0042476 odontogenesis ISS 15629145 GO:0043410 positive regulation of MAPK cascade IMP GO:0043547 positive regulation of GTPase activity IEA GO:0045165 cell fate commitment ISS 15190072 GO:0045667 regulation of osteoblast differentiation TAS GO:0045787 positive regulation of cell cycle ISS GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS 15629145 GO:0046777 protein autophosphorylation IDA GO:0046854 phosphatidylinositol phosphorylation IEA GO:0048015 phosphatidylinositol-mediated signaling TAS GO:0048286 lung alveolus development ISS GO:0048333 mesodermal cell differentiation IEA GO:0048557 embryonic digestive tract morphogenesis ISS GO:0048562 embryonic organ morphogenesis ISS GO:0048565 digestive tract development ISS GO:0048568 embryonic organ development ISS GO:0048608 reproductive structure development ISS GO:0048661 positive regulation of smooth muscle cell proliferation IEA 7874170 7987400 GO:0048701 embryonic cranial skeleton morphogenesis IMP 15190072 GO:0048705 skeletal system morphogenesis TAS GO:0048730 epidermis morphogenesis ISS GO:0048755 branching morphogenesis of a nerve ISS GO:0048762 mesenchymal cell differentiation ISS GO:0050679 positive regulation of epithelial cell proliferation ISS GO:0050680 negative regulation of epithelial cell proliferation IEA GO:0051150 regulation of smooth muscle cell differentiation ISS GO:0051781 positive regulation of cell division ISS GO:0055010 ventricular cardiac muscle tissue morphogenesis ISS GO:0060045 positive regulation of cardiac muscle cell proliferation ISS GO:0060174 limb bud formation ISS GO:0060348 bone development ISS GO:0060349 bone morphogenesis ISS GO:0060442 branching involved in prostate gland morphogenesis ISS GO:0060445 branching involved in salivary gland morphogenesis ISS GO:0060449 bud elongation involved in lung branching ISS GO:0060463 lung lobe morphogenesis ISS GO:0060484 lung-associated mesenchyme development ISS GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis ISS GO:0060512 prostate gland morphogenesis ISS GO:0060523 prostate epithelial cord elongation ISS GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis ISS GO:0060529 squamous basal epithelial stem cell differentiation involved in prostate gland acinus development ISS GO:0060595 fibroblast growth factor receptor signaling pathway involved in mammary gland specification ISS GO:0060601 lateral sprouting from an epithelium ISS GO:0060615 mammary gland bud formation ISS GO:0060664 epithelial cell proliferation involved in salivary gland morphogenesis ISS GO:0060667 branch elongation involved in salivary gland morphogenesis ISS GO:0060670 branching involved in labyrinthine layer morphogenesis ISS GO:0060687 regulation of branching involved in prostate gland morphogenesis ISS GO:0060688 regulation of morphogenesis of a branching structure ISS GO:0060915 mesenchymal cell differentiation involved in lung development ISS GO:0060916 mesenchymal cell proliferation involved in lung development ISS GO:0070372 regulation of ERK1 and ERK2 cascade ISS GO:0070374 positive regulation of ERK1 and ERK2 cascade ISS GO:0090263 positive regulation of canonical Wnt signaling pathway ISS,"GO:0004713 protein tyrosine kinase activity 1697263 NAS GO:0004713 protein tyrosine kinase activity TAS GO:0005007 fibroblast growth factor-activated receptor activity 8663044 15629145 IDA GO:0005007 fibroblast growth factor-activated receptor activity 10830168 IGI GO:0005007 fibroblast growth factor-activated receptor activity 1400433 1697263 8676562 NAS GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS GO:0005515 protein binding 1309608 10618369 10830168 11069186 11390973 12591959 22726438 23597563 25241761 26267536 IPI GO:0005524 ATP binding IEA GO:0008201 heparin binding IEA GO:0016303 1-phosphatidylinositol-3-kinase activity TAS GO:0017134 fibroblast growth factor binding 8663044 IDA GO:0017134 fibroblast growth factor binding 8386828 IPI GO:0042803 protein homodimerization activity 16844695 IPI GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS",hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04144 Endocytosis - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human),chemicalprobes.org BGJ-398,P22607,Fibroblast growth factor receptor 3,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2261,FGFR3,"PI3K Cascade R-HSA-109704 IRS-mediated signalling R-HSA-112399 SOS-mediated signalling R-HSA-112412 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 Signaling by FGFR in disease R-HSA-1226099 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 SHC1 events in ERBB2 signaling R-HSA-1250196 PI3K events in ERBB4 signaling R-HSA-1250342 SHC1 events in ERBB4 signaling R-HSA-1250347 PIP3 activates AKT signaling R-HSA-1257604 Developmental Biology R-HSA-1266738 Cytokine Signaling in Immune system R-HSA-1280215 Adaptive Immune System R-HSA-1280218 Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Prolonged ERK activation events R-HSA-169893 Frs2-mediated activation R-HSA-170968 ARMS-mediated activation R-HSA-170984 Signaling by EGFR R-HSA-177929 GRB2 events in EGFR signaling R-HSA-179812 GAB1 signalosome R-HSA-180292 SHC1 events in EGFR signaling R-HSA-180336 Signaling by activated point mutants of FGFR3 R-HSA-1839130 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signalling to p38 via RIT and RIN R-HSA-187706 Signaling by FGFR R-HSA-190236 FGFR3 ligand binding and activation R-HSA-190239 FGFR3b ligand binding and activation R-HSA-190371 FGFR3c ligand binding and activation R-HSA-190372 Signaling by VEGF R-HSA-194138 GRB2 events in ERBB2 signaling R-HSA-1963640 PI3K events in ERBB2 signaling R-HSA-1963642 PI3K/AKT activation R-HSA-198203 FGFR3 mutant receptor activation R-HSA-2033514 t(4;14) translocations of FGFR3 R-HSA-2033515 DAP12 interactions R-HSA-2172127 PI3K/AKT Signaling in Cancer R-HSA-2219528 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Signaling by Leptin R-HSA-2586552 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 FCERI mediated MAPK activation R-HSA-2871796 Signaling by GPCR R-HSA-372790 NCAM signaling for neurite out-growth R-HSA-375165 Axon guidance R-HSA-422475 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signaling by Interleukins R-HSA-449147 Interleukin-2 signaling R-HSA-451927 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 VEGFR2 mediated cell proliferation R-HSA-5218921 Phospholipase C-mediated cascade; FGFR3 R-HSA-5654227 Downstream signaling of activated FGFR1 R-HSA-5654687 PI-3K cascade:FGFR1 R-HSA-5654689 FRS-mediated FGFR1 signaling R-HSA-5654693 PI-3K cascade:FGFR2 R-HSA-5654695 Downstream signaling of activated FGFR2 R-HSA-5654696 FRS-mediated FGFR2 signaling R-HSA-5654700 SHC-mediated cascade:FGFR3 R-HSA-5654704 FRS-mediated FGFR3 signaling R-HSA-5654706 Downstream signaling of activated FGFR3 R-HSA-5654708 PI-3K cascade:FGFR3 R-HSA-5654710 FRS-mediated FGFR4 signaling R-HSA-5654712 Downstream signaling of activated FGFR4 R-HSA-5654716 PI-3K cascade:FGFR4 R-HSA-5654720 Negative regulation of FGFR3 signaling R-HSA-5654732 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 Signaling by FGFR3 mutants R-HSA-5655272 Signaling by FGFR3 in disease R-HSA-5655332 Diseases of signal transduction R-HSA-5663202 RAF/MAP kinase cascade R-HSA-5673001 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 Interleukin receptor SHC signaling R-HSA-912526 Signaling by the B Cell Receptor (BCR) R-HSA-983705",extracellular region GO:0005576 IEA nucleus GO:0005634 IEA endoplasmic reticulum GO:0005783 IDA Golgi apparatus 18061161 GO:0005794 IDA plasma membrane 18061161 GO:0005886 IDA plasma membrane GO:0005886 TAS integral component of plasma membrane 8663044 GO:0005887 IDA focal adhesion colocalizes_with 15748888 GO:0005925 TAS cell surface GO:0009986 IEA transport vesicle 18061161 GO:0030133 IDA,MAPK cascade TAS GO:0000165 skeletal system development TAS 8601314 GO:0001501 endochondral ossification TAS 15748888 GO:0001958 chondrocyte differentiation TAS 15748888 GO:0002062 endochondral bone growth TAS 15748888 GO:0003416 JAK-STAT cascade TAS 10918587 GO:0007259 cell-cell signaling IEA GO:0007267 positive regulation of cell proliferation IGI 8663044 GO:0008284 positive regulation of cell proliferation IMP 8663044 11294897 GO:0008284 fibroblast growth factor receptor signaling pathway IDA 8663044 GO:0008543 fibroblast growth factor receptor signaling pathway IGI 8663044 GO:0008543 fibroblast growth factor receptor signaling pathway TAS GO:0008543 positive regulation of phospholipase activity IMP 17561467 GO:0010518 regulation of phosphatidylinositol 3-kinase signaling TAS GO:0014066 peptidyl-tyrosine phosphorylation IDA 11294897 GO:0018108 bone mineralization ISS 20582225 GO:0030282 chondrocyte proliferation TAS 15748888 GO:0035988 phosphatidylinositol-3-phosphate biosynthetic process IEA GO:0036092 positive regulation of tyrosine phosphorylation of Stat1 protein IMP 11294897 17561467 GO:0042511 positive regulation of tyrosine phosphorylation of Stat3 protein IMP 11294897 GO:0042517 positive regulation of MAPK cascade IMP 11294897 GO:0043410 positive regulation of GTPase activity IEA GO:0043547 positive regulation of phosphatidylinositol 3-kinase activity IMP 11294897 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity TAS 15748888 GO:0043552 protein autophosphorylation IDA 11294897 GO:0046777 phosphatidylinositol phosphorylation IEA GO:0046854 phosphatidylinositol-mediated signaling TAS GO:0048015 negative regulation of developmental growth ISS 20582225 GO:0048640 bone morphogenesis ISS 20582225 GO:0060349 bone morphogenesis TAS 15748888 GO:0060349 positive regulation of ERK1 and ERK2 cascade IMP 11294897 GO:0070374 bone maturation ISS 20582225 GO:0070977 fibroblast growth factor receptor apoptotic signaling pathway IMP 17561467 GO:1902178,"protein tyrosine kinase activity GO:0004713 IDA 11294897 protein tyrosine kinase activity GO:0004713 TAS fibroblast growth factor-activated receptor activity GO:0005007 IMP 8663044 Ras guanyl-nucleotide exchange factor activity GO:0005088 TAS protein binding GO:0005515 IPI 14732692 22939624 ATP binding GO:0005524 IEA 1-phosphatidylinositol-3-kinase activity GO:0016303 TAS fibroblast growth factor binding GO:0017134 IDA 8663044 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 TAS",MAPK signaling pathway - Homo sapiens (human) hsa04010 Ras signaling pathway - Homo sapiens (human) hsa04014 Rap1 signaling pathway - Homo sapiens (human) hsa04015 Endocytosis - Homo sapiens (human) hsa04144 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04550 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04810 Pathways in cancer - Homo sapiens (human) hsa05200 MicroRNAs in cancer - Homo sapiens (human) hsa05206 Bladder cancer - Homo sapiens (human) hsa05219 Central carbon metabolism in cancer - Homo sapiens (human) hsa05230,chemicalprobes.org BGJ-398,P22455,Fibroblast growth factor receptor 4,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2264,FGFR4,"R-HSA-109704 PI3K Cascade R-HSA-112399 IRS-mediated signalling R-HSA-112412 SOS-mediated signalling R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1226099 Signaling by FGFR in disease R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250196 SHC1 events in ERBB2 signaling R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1250347 SHC1 events in ERBB4 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1266738 Developmental Biology R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-1307965 betaKlotho-mediated ligand binding R-HSA-1307973 Klotho-mediated ligand binding R-HSA-1433557 Signaling by SCF-KIT R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-166520 Signalling by NGF R-HSA-167044 Signalling to RAS R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-169893 Prolonged ERK activation events R-HSA-170968 Frs2-mediated activation R-HSA-170984 ARMS-mediated activation R-HSA-177929 Signaling by EGFR R-HSA-179812 GRB2 events in EGFR signaling R-HSA-180292 GAB1 signalosome R-HSA-180336 SHC1 events in EGFR signaling R-HSA-1839128 FGFR4 mutant receptor activation R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-187687 Signalling to ERKs R-HSA-187706 Signalling to p38 via RIT and RIN R-HSA-190236 Signaling by FGFR R-HSA-190322 FGFR4 ligand binding and activation R-HSA-194138 Signaling by VEGF R-HSA-1963640 GRB2 events in ERBB2 signaling R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2586552 Signaling by Leptin R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-372790 Signaling by GPCR R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-422475 Axon guidance R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-5654228 Phospholipase C-mediated cascade; FGFR4 R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654719 SHC-mediated cascade:FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654733 Negative regulation of FGFR4 signaling R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5655291 Signaling by FGFR4 in disease R-HSA-5655324 Signaling by FGFR4 mutants R-HSA-5663202 Diseases of signal transduction R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5683057 MAPK family signaling cascades R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-912526 Interleukin receptor SHC signaling R-HSA-983705 Signaling by the B Cell Receptor (BCR)",GO:0005576 extracellular region IEA GO:0005654 nucleoplasm IDA GO:0005737 cytoplasm IDA GO:0005768 endosome IEA 20683963 GO:0005783 endoplasmic reticulum IDA 18061161 GO:0005794 Golgi apparatus IDA 18061161 GO:0005886 plasma membrane IDA GO:0005886 plasma membrane TAS 20683963 GO:0005887 integral component of plasma membrane IDA 20798051 GO:0005911 cell-cell junction IDA colocalizes_with 18061161 GO:0030133 transport vesicle IDA,GO:0000165 MAPK cascade TAS GO:0008284 positive regulation of cell proliferation 8663044 IDA GO:0008284 positive regulation of cell proliferation 8663044 IGI GO:0008543 fibroblast growth factor receptor signaling pathway 21653700 IDA GO:0008543 fibroblast growth factor receptor signaling pathway 8663044 IGI GO:0008543 fibroblast growth factor receptor signaling pathway 10525310 IPI GO:0008543 fibroblast growth factor receptor signaling pathway TAS GO:0010628 positive regulation of gene expression 19085950 IMP GO:0010715 regulation of extracellular matrix disassembly 20876804 IMP GO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS GO:0016477 cell migration 20876804 IMP GO:0018108 peptidyl-tyrosine phosphorylation 18480409 20683963 IDA GO:0019216 regulation of lipid metabolic process ISS GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA GO:0042593 glucose homeostasis ISS GO:0043085 positive regulation of catalytic activity 20798051 IMP GO:0043547 positive regulation of GTPase activity IEA GO:0045862 positive regulation of proteolysis 20798051 IMP GO:0046777 protein autophosphorylation 20798051 IDA GO:0046854 phosphatidylinositol phosphorylation IEA GO:0048015 phosphatidylinositol-mediated signaling TAS GO:0055062 phosphate ion homeostasis ISS GO:0070374 positive regulation of ERK1 and ERK2 cascade 21653700 IMP GO:0070857 regulation of bile acid biosynthetic process 17623664 20683963 IMP GO:1903412 response to bile acid NOT 19085950 IMP GO:2000188 regulation of cholesterol homeostasis ISS GO:2000573 positive regulation of DNA biosynthetic process 21653700 IMP,"TAS GO:0004713 protein tyrosine kinase activity IDA 8663044 18480409 21653700 fibroblast growth factor-activated receptor activity GO:0005007 IGI 10525310 fibroblast growth factor-activated receptor activity GO:0005007 TAS GO:0005088 Ras guanyl-nucleotide exchange factor activity IPI 17627937 protein binding GO:0005515 IEA GO:0005524 ATP binding IDA 18480409 heparin binding GO:0008201 TAS GO:0016303 1-phosphatidylinositol-3-kinase activity IDA 8663044 18480409 fibroblast growth factor binding GO:0017134 IPI 10525310 17627937 fibroblast growth factor binding GO:0017134 TAS GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity",hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04144 Endocytosis - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human),chemicalprobes.org CHIR-99021,P49840,Glycogen synthase kinase-3 alpha,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2931,GSK3A,R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1280218 Adaptive Immune System R-HSA-1433557 Signaling by SCF-KIT R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-166520 Signalling by NGF R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-177929 Signaling by EGFR R-HSA-180292 GAB1 signalosome R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-190236 Signaling by FGFR R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-198323 AKT phosphorylates targets in the cytosol R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2424491 DAP12 signaling R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5663202 Diseases of signal transduction R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer R-HSA-983705 Signaling by the B Cell Receptor (BCR),mitochondrion GO:0005739 IEA cytosol GO:0005829 11035810 TAS beta-catenin destruction complex GO:0030877 19759537 NAS beta-catenin destruction complex GO:0030877 19366350 TAS postsynapse GO:0098794 IEA,"GO:0003073 regulation of systemic arterial blood pressure ISS GO:0003214 cardiac left ventricle morphogenesis ISS GO:0005977 glycogen metabolic process IEA 11035810 GO:0006468 protein phosphorylation IDA 21711983 GO:0007212 dopamine receptor signaling pathway NAS GO:0007399 nervous system development IEA 18285345 GO:0008286 insulin receptor signaling pathway ISS 11035810 GO:0010905 negative regulation of UDP-glucose catabolic process IC GO:0016055 Wnt signaling pathway IEA GO:0030819 positive regulation of cAMP biosynthetic process ISS GO:0032007 negative regulation of TOR signaling ISS 17569761 GO:0032869 cellular response to insulin stimulus IMP GO:0036016 cellular response to interleukin-3 ISS GO:0036498 IRE1-mediated unfolded protein response TAS GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process ISS 19366350 GO:0045719 negative regulation of glycogen biosynthetic process TAS 19759537 GO:0045732 positive regulation of protein catabolic process NAS GO:0045823 positive regulation of heart contraction ISS 17569761 GO:0046325 negative regulation of glucose import IMP 17569761 GO:0046627 negative regulation of insulin receptor signaling pathway IMP GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development ISS GO:0071879 positive regulation of adrenergic receptor signaling pathway ISS 19366350 GO:0090090 negative regulation of canonical Wnt signaling pathway TAS GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand ISS 21711983 GO:0099565 chemical synaptic transmission, postsynaptic NAS GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISS 24912190 GO:1903146 regulation of mitophagy IMP 24912190 GO:1903955 positive regulation of protein targeting to mitochondrion IMP 17569761 GO:1904227 negative regulation of glycogen synthase activity, transferring glucose-1-phosphate IMP 19366350 GO:2000077 negative regulation of type B pancreatic cell development TAS 19366350 GO:2000466 negative regulation of glycogen (starch) synthase activity TAS GO:2000467 positive regulation of glycogen (starch) synthase activity ISS",GO:0004674 protein serine/threonine kinase activity 11035810 IDA GO:0005515 protein binding 16365045 17318175 19706605 20368287 22939624 23602568 24705354 IPI GO:0005524 ATP binding IEA GO:0034236 protein kinase A catalytic subunit binding 11035810 IPI GO:0050321 tau-protein kinase activity 19366350 TAS,hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04728 Dopaminergic synapse - Homo sapiens (human) hsa04932 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human),chemicalprobes.org CHIR-99021,P49841,Glycogen synthase kinase-3 beta,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2932,GSK3B,"Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 PI3K events in ERBB4 signaling R-HSA-1250342 PIP3 activates AKT signaling R-HSA-1257604 Developmental Biology R-HSA-1266738 Adaptive Immune System R-HSA-1280218 Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Signalling by NGF R-HSA-166520 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Signaling by EGFR R-HSA-177929 GAB1 signalosome R-HSA-180292 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signaling by FGFR R-HSA-190236 Degradation of beta-catenin by the destruction complex R-HSA-195253 Signaling by Wnt R-HSA-195721 Beta-catenin phosphorylation cascade R-HSA-196299 PI3K events in ERBB2 signaling R-HSA-1963642 PI3K/AKT activation R-HSA-198203 AKT phosphorylates targets in the cytosol R-HSA-198323 TCF dependent signaling in response to WNT R-HSA-201681 DAP12 interactions R-HSA-2172127 PI3K/AKT Signaling in Cancer R-HSA-2219528 Cellular responses to stress R-HSA-2262752 DAP12 signaling R-HSA-2424491 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 Regulation of HSF1-mediated heat shock response R-HSA-3371453 Cellular response to heat stress R-HSA-3371556 Semaphorin interactions R-HSA-373755 CRMPs in Sema3A signaling R-HSA-399956 Axon guidance R-HSA-422475 disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 Signaling by Hedgehog R-HSA-5358351 Degradation of GLI2 by the proteasome R-HSA-5610783 GLI3 is processed to GLI3R by the proteasome R-HSA-5610785 Hedgehog ,off, state R-HSA-5610787 Downstream signaling of activated FGFR1 R-HSA-5654687 PI-3K cascade:FGFR1 R-HSA-5654689 PI-3K cascade:FGFR2 R-HSA-5654695 Downstream signaling of activated FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR3 R-HSA-5654708 PI-3K cascade:FGFR3 R-HSA-5654710 Downstream signaling of activated FGFR4 R-HSA-5654716 PI-3K cascade:FGFR4 R-HSA-5654720 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 Diseases of signal transduction R-HSA-5663202 Constitutive Signaling by AKT1 E17K in Cancer R-HSA-5674400 Signaling by the B Cell Receptor (BCR) R-HSA-983705",nucleus 14744935 15448698 GO:0005634 IDA cytoplasm 14744935 15448698 18787224 19038973 20937854 GO:0005737 IDA mitochondrion GO:0005739 IEA centrosome 21399614 GO:0005813 IDA cytosol GO:0005829 TAS plasma membrane 20937854 GO:0005886 IDA axon GO:0030424 IEA growth cone GO:0030426 IEA intracellular ribonucleoprotein complex GO:0030529 IEA beta-catenin destruction complex 8638126 9601641 16188939 GO:0030877 IDA beta-catenin destruction complex 11955436 19366350 GO:0030877 TAS neuronal cell body GO:0043025 IEA dendritic spine GO:0043197 IEA dendritic shaft GO:0043198 IEA membrane raft GO:0045121 IEA perinuclear region of cytoplasm GO:0048471 IEA Wnt signalosome 24115276 GO:1990909 TAS,"re-entry into mitotic cell cycle IEA GO:0000320 epithelial to mesenchymal transition IMP 15448698 GO:0001837 positive regulation of cell-matrix adhesion IMP 18156211 GO:0001954 glycogen metabolic process IDA 8638126 GO:0005977 regulation of gene expression by genetic imprinting IEA GO:0006349 protein phosphorylation IDA 11035810 16315267 20937854 GO:0006468 protein export from nucleus IEA GO:0006611 ER overload response IDA 14744935 GO:0006983 dopamine receptor signaling pathway NAS 21711983 GO:0007212 axonogenesis IEA GO:0007409 myoblast fusion IEA GO:0007520 aging IEA GO:0007568 circadian rhythm ISS GO:0007623 organ morphogenesis IEA GO:0009887 negative regulation of cardiac muscle hypertrophy IEA GO:0010614 positive regulation of peptidyl-threonine phosphorylation IEA GO:0010800 positive regulation of mitochondrial membrane potential IEA GO:0010918 negative regulation of neuron maturation IEA GO:0014043 response to activity IEA GO:0014823 Wnt signaling pathway TAS GO:0016055 cell migration IEA GO:0016477 peptidyl-serine phosphorylation IDA 8638126 11104755 11955436 14744935 GO:0018105 peptidyl-threonine phosphorylation IDA 11955436 GO:0018107 hippocampus development IMP 19581563 GO:0021766 establishment of cell polarity IEA GO:0030010 negative regulation of protein complex assembly IMP 16188939 GO:0031333 positive regulation of protein complex assembly IDA 8638126 GO:0031334 negative regulation of protein binding IDA 16890161 GO:0032091 positive regulation of protein binding ISS GO:0032092 response to estradiol IEA GO:0032355 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IC 11955436 GO:0032436 response to insulin IEA GO:0032868 regulation of microtubule-based process IMP 20937854 GO:0032886 positive regulation of peptidyl-serine phosphorylation IEA GO:0033138 negative regulation of smooth muscle cell apoptotic process IEA GO:0034392 protein localization to microtubule IEA GO:0035372 intracellular signal transduction IDA 14749367 GO:0035556 cellular response to hepatocyte growth factor stimulus IEA GO:0035729 cellular response to interleukin-3 ISS GO:0036016 cellular response to erythropoietin IEA GO:0036018 response to drug IEA GO:0042493 negative regulation of apoptotic process IDA 14744935 GO:0043066 proteasome-mediated ubiquitin-dependent protein catabolic process TAS GO:0043161 negative regulation of MAP kinase activity IEA GO:0043407 positive regulation of neuron apoptotic process IEA GO:0043525 positive regulation of GTPase activity IMP 18156211 GO:0043547 hypermethylation of CpG island IEA GO:0044027 canonical Wnt signaling pathway involved in positive regulation of apoptotic process IEA GO:0044337 fat cell differentiation IEA GO:0045444 negative regulation of glycogen biosynthetic process TAS 19366350 GO:0045719 positive regulation of protein catabolic process IC 16188939 GO:0045732 positive regulation of axon extension IEA GO:0045773 positive regulation of transcription from RNA polymerase II promoter IEA GO:0045944 protein autophosphorylation IDA 23184662 GO:0046777 positive regulation of protein export from nucleus IDA 14744935 GO:0046827 regulation of neuronal synaptic plasticity IEA GO:0048168 positive regulation of smooth muscle cell proliferation IEA GO:0048661 negative regulation of dendrite morphogenesis IEA GO:0050774 negative regulation of nitric-oxide synthase activity IEA GO:0051001 negative regulation of NFAT protein import into nucleus IMP 9072970 GO:0051534 canonical Wnt signaling pathway IC 9601641 GO:0060070 canonical Wnt signaling pathway IDA 18787224 GO:0060070 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA GO:0070059 cellular response to hydrogen peroxide IEA GO:0070301 superior temporal gyrus development IMP 19581563 GO:0071109 cellular response to mechanical stimulus IEA GO:0071260 cellular response to iron(II) ion IEA GO:0071282 cellular response to lithium ion IEA GO:0071285 response to epinephrine IEA GO:0071871 negative regulation of canonical Wnt signaling pathway IC 11955436 GO:0090090 negative regulation of canonical Wnt signaling pathway TAS 19366350 GO:0090090 extrinsic apoptotic signaling pathway in absence of ligand ISS GO:0097192 chemical synaptic transmission, postsynaptic NAS 21711983 GO:0099565 regulation of cellular response to heat TAS GO:1900034 negative regulation of protein localization to nucleus ISS GO:1900181 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISS GO:1901030 positive regulation of neuron death IDA 18508033 GO:1901216 response to L-glutamate IEA GO:1902065 cellular response to dopamine IEA GO:1903351 negative regulation of dopaminergic neuron differentiation TAS 24431302 GO:1904339 beta-catenin destruction complex assembly TAS GO:1904885 beta-catenin destruction complex disassembly TAS GO:1904886 response to insulin-like growth factor stimulus IEA GO:1990418 response to ultrasound IEA GO:1990478 response to angiotensin IEA GO:1990776 negative regulation of type B pancreatic cell development TAS 19366350 GO:2000077 positive regulation of excitatory postsynaptic potential IEA GO:2000463 negative regulation of glycogen (starch) synthase activity TAS 19366350 GO:2000466 positive regulation of DNA biosynthetic process IEA GO:2000573 positive regulation of stem cell differentiation IEA GO:2000738 negative regulation of neuron migration IEA GO:2001223",RNA polymerase II transcription factor binding GO:0001085 IPI 20864106 p53 binding GO:0002039 IDA 14744935 protein kinase activity GO:0004672 TAS 22988876 24115276 protein serine/threonine kinase activity GO:0004674 IDA 8638126 9072970 11035810 11104755 11955436 14744935 16315267 18348280 protein serine/threonine kinase activity GO:0004674 ISS protein serine/threonine kinase activity GO:0004674 TAS integrin binding GO:0005178 IEA protein binding GO:0005515 IPI 8638126 9482734 9601641 9731200 11004522 11035810 12421363 12434148 12927815 14744935 15147888 15448698 15752768 16282323 16365045 16890161 17078951 17139249 17317006 17318191 17601533 18045539 19131971 19249679 19303846 19411070 19706605 19759537 20080667 20368287 20389281 20856200 21118991 21217772 21242974 21743491 21900206 21985244 21988832 22470507 22682247 22699938 22773187 23010592 23455922 23602568 24165324 24391509 24976009 25241761 26496610 ATP binding GO:0005524 IEA beta-catenin binding GO:0008013 IPI 8638126 kinase activity GO:0016301 IDA 15448698 24391509 kinase activity GO:0016301 TAS protein kinase binding GO:0019901 IPI 18348280 ubiquitin protein ligase binding GO:0031625 IPI 21118991 protein kinase A catalytic subunit binding GO:0034236 IPI 11035810 ionotropic glutamate receptor binding GO:0035255 IEA tau protein binding GO:0048156 IEA tau-protein kinase activity GO:0050321 IDA 14690523 16365045 NF-kappaB binding GO:0051059 IPI 15465828,"ErbB signaling pathway - Homo sapiens (human) hsa04012 Chemokine signaling pathway - Homo sapiens (human) hsa04062 Cell cycle - Homo sapiens (human) hsa04110 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Wnt signaling pathway - Homo sapiens (human) hsa04310 Hedgehog signaling pathway - Homo sapiens (human) hsa04340 Axon guidance - Homo sapiens (human) hsa04360 Hippo signaling pathway - Homo sapiens (human) hsa04390 Focal adhesion - Homo sapiens (human) hsa04510 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04550 T cell receptor signaling pathway - Homo sapiens (human) hsa04660 B cell receptor signaling pathway - Homo sapiens (human) hsa04662 Neurotrophin signaling pathway - Homo sapiens (human) hsa04722 Dopaminergic synapse - Homo sapiens (human) hsa04728 Insulin signaling pathway - Homo sapiens (human) hsa04910 Melanogenesis - Homo sapiens (human) hsa04916 Prolactin signaling pathway - Homo sapiens (human) hsa04917 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04919 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa04932 Alzheimer,s disease - Homo sapiens (human) hsa05010 Hepatitis C - Homo sapiens (human) hsa05160 Measles - Homo sapiens (human) hsa05162 Influenza A - Homo sapiens (human) hsa05164 HTLV-I infection - Homo sapiens (human) hsa05166 Epstein-Barr virus infection - Homo sapiens (human) hsa05169 Pathways in cancer - Homo sapiens (human) hsa05200 Colorectal cancer - Homo sapiens (human) hsa05210 Endometrial cancer - Homo sapiens (human) hsa05213 Prostate cancer - Homo sapiens (human) hsa05215 Basal cell carcinoma - Homo sapiens (human) hsa05217",chemicalprobes.org SGX-523,P08581,Hepatocyte growth factor receptor,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,4233,MET,R-HSA-1266738 Developmental Biology R-HSA-373755 Semaphorin interactions R-HSA-400685 Sema4D in semaphorin signaling R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration R-HSA-422475 Axon guidance,extracellular region GO:0005576 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 TAS 1846706 basal plasma membrane GO:0009925 IDA 15314156 cell surface GO:0009986 IDA 19581412 integral component of membrane GO:0016021 NAS 2819873,14500721 IDA GO:0001886 endothelial cell morphogenesis 1846706 TAS GO:0007165 signal transduction 2819873 NAS GO:0007166 cell surface receptor signaling pathway 10871856 TAS GO:0008283 cell proliferation 24743740 NAS GO:0010507 negative regulation of autophagy IEA GO:0018108 peptidyl-tyrosine phosphorylation 22521434 IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0048012 hepatocyte growth factor receptor signaling pathway 16153003 IMP GO:0048754 branching morphogenesis of an epithelial tube 15218527 IDA GO:0050918 positive chemotaxis 15218527 IDA GO:0071526 semaphorin-plexin signaling pathway 20655899 IMP GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death 19850054 IMP GO:2001028 positive regulation of endothelial cell chemotaxis,protein tyrosine kinase activity 3325883 GO:0004713 NAS protein tyrosine kinase activity GO:0004713 TAS hepatocyte growth factor-activated receptor activity 10871856 GO:0005008 TAS protein binding 1846706 11571281 11590178 12475979 15167892 15184888 16101282 16537444 17662939 17981115 18273061 18579758 19167335 20624308 20802513 21163258 21242965 22404908 22789536 22897854 22962849 23866081 24034250 24189400 24728074 25241761 GO:0005515 IPI ATP binding GO:0005524 IEA protein phosphatase binding 18819921 GO:0019903 IPI,hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) hsa04144 Endocytosis - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04360 Axon guidance - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04520 Adherens junction - Homo sapiens (human) hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human) hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) hsa05144 Malaria - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05211 Renal cell carcinoma - Homo sapiens (human) hsa05218 Melanoma - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human),chemicalprobes.org SGC-CBP30,Q09472,Histone acetyltransferase p300,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2033,EP300,"Developmental Biology R-HSA-1266738 RORA activates gene expression R-HSA-1368082 Polo-like kinase mediated events R-HSA-156711 Signaling by NOTCH R-HSA-157118 Signal Transduction R-HSA-162582 Cell Cycle R-HSA-1640170 Disease R-HSA-1643685 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways R-HSA-168928 Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 Signaling by Wnt R-HSA-195721 Signaling by NOTCH1 R-HSA-1980143 Signaling by NOTCH2 R-HSA-1980145 TCF dependent signaling in response to WNT R-HSA-201681 formation of the beta-catenin:TCF transactivating complex R-HSA-201722 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 NOTCH2 intracellular domain regulates transcription R-HSA-2197563 Cellular responses to stress R-HSA-2262752 Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 Signaling by NOTCH1 in Cancer R-HSA-2644603 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 HATs acetylate histones R-HSA-3214847 Chromatin modifying enzymes R-HSA-3247509 Cellular response to heat stress R-HSA-3371556 Attenuation phase R-HSA-3371568 HSF1-dependent transactivation R-HSA-3371571 Transcriptional regulation of white adipocyte differentiation R-HSA-381340 Circadian Clock R-HSA-400253 Mitotic G2-G2/M phases R-HSA-453274 Chromatin organization R-HSA-4839726 C-type lectin receptors (CLRs) R-HSA-5621481 CD209 (DC-SIGN) signaling R-HSA-5621575 Diseases of signal transduction R-HSA-5663202 G2/M Transition R-HSA-69275 Cell Cycle, Mitotic R-HSA-69278 TRAF3-dependent IRF activation pathway R-HSA-918233 TRAF6 mediated IRF7 activation R-HSA-933541",histone acetyltransferase complex GO:0000123 IEA chromatin GO:0000785 IEA nucleus GO:0005634 9194565 12929931 14645221 IDA nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS transcription factor complex GO:0005667 IEA cytoplasm GO:0005737 IDA protein-DNA complex GO:0032993 IEA,"negative regulation of transcription from RNA polymerase II promoter 10733570 GO:0000122 IDA response to hypoxia 9887100 15261140 GO:0001666 IDA somitogenesis GO:0001756 IEA liver development GO:0001889 IEA positive regulation of protein phosphorylation GO:0001934 IEA stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS transcription-coupled nucleotide-excision repair GO:0006283 TAS regulation of transcription, DNA-templated 15261140 GO:0006355 IDA transcription from RNA polymerase II promoter GO:0006366 IEA protein acetylation 21030595 24939902 GO:0006473 IDA protein acetylation 22013210 GO:0006473 TAS internal protein amino acid acetylation 18722353 GO:0006475 IDA apoptotic process 9194565 GO:0006915 IMP DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 TAS positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response GO:0006990 ISS Notch signaling pathway GO:0007219 TAS nervous system development 10205054 GO:0007399 TAS heart development GO:0007507 IEA skeletal muscle tissue development GO:0007519 IEA memory GO:0007613 IEA circadian rhythm GO:0007623 ISS organ morphogenesis GO:0009887 IEA regulation of autophagy 24852146 GO:0010506 TAS positive regulation of glycoprotein biosynthetic process GO:0010560 IEA positive regulation of cell death GO:0010942 IEA positive regulation of muscle atrophy GO:0014737 IEA viral process GO:0016032 IEA N-terminal peptidyl-lysine acetylation 12435739 GO:0018076 IDA internal peptidyl-lysine acetylation 17403783 GO:0018393 IDA B cell differentiation GO:0030183 IEA platelet formation GO:0030220 IEA lung development GO:0030324 IEA response to cobalt ion GO:0032025 IEA positive regulation of protein binding GO:0032092 IEA positive regulation of type I interferon production GO:0032481 TAS positive regulation of collagen biosynthetic process GO:0032967 IEA positive regulation of protein import into nucleus, translocation GO:0033160 IEA response to tumor necrosis factor GO:0034612 IEA cellular response to UV 24939902 GO:0034644 IDA positive regulation of histone acetylation GO:0035066 IEA cellular response to drug GO:0035690 IEA megakaryocyte development GO:0035855 IEA cellular response to trichostatin A GO:0035984 IEA intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 17403783 GO:0042771 IDA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IEA positive regulation of DNA binding GO:0043388 IEA protein kinase B signaling GO:0043491 IEA response to estrogen 11581164 GO:0043627 IDA positive regulation by host of viral transcription 16687403 GO:0043923 IDA histone H3 acetylation GO:0043966 IEA histone H4 acetylation 16325578 GO:0043967 IMP histone H2B acetylation 23415232 GO:0043969 IDA fat cell differentiation GO:0045444 ISS response to ethanol GO:0045471 IEA positive regulation of translation GO:0045727 IEA positive regulation of axon extension GO:0045773 IEA positive regulation of cell size GO:0045793 IEA positive regulation of gene expression, epigenetic GO:0045815 TAS positive regulation of proteolysis GO:0045862 IEA positive regulation of transcription from RNA polymerase II promoter 12586840 18722353 GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter 16325578 GO:0045944 IMP digestive tract development GO:0048565 IEA positive regulation of protein secretion GO:0050714 IEA protein stabilization GO:0050821 ISS positive regulation of sequence-specific DNA binding transcription factor activity 10518217 GO:0051091 IDA response to calcium ion GO:0051592 IEA regulation of cell cycle GO:0051726 TAS regulation of angiotensin metabolic process GO:0060177 IEA positive regulation of sarcomere organization GO:0060298 IEA regulation of androgen receptor signaling pathway 18487222 GO:0060765 IDA regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 TAS protein-DNA complex assembly GO:0065004 IEA cellular response to hydrogen peroxide GO:0070301 IEA response to fatty acid GO:0070542 IEA cellular response to retinoic acid GO:0071300 IEA cellular response to cAMP GO:0071320 IEA cellular response to glucose stimulus GO:0071333 IEA cellular response to mineralocorticoid stimulus GO:0071389 IEA cellular response to dexamethasone stimulus GO:0071549 IEA regulation of tubulin deacetylation 18722353 GO:0090043 IDA regulation of cellular response to heat GO:1900034 TAS regulation of signal transduction by p53 class mediator GO:1901796 TAS beta-catenin-TCF complex assembly GO:1904837 TAS cellular response to nerve growth factor stimulus GO:1990090 IEA negative regulation of miRNA metabolic process GO:2000629 IEA","GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA 17641689 GO:0001047 core promoter binding IDA 20018936 GO:0001102 RNA polymerase II activating transcription factor binding IPI GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA GO:0002039 p53 binding IEA 9194565 GO:0003677 DNA binding IDA 24939902 GO:0003682 chromatin binding IDA 17641689 GO:0003682 chromatin binding IMP 24939902 GO:0003684 damaged DNA binding IDA 12435739 12586840 16687403 18487222 GO:0003713 transcription coactivator activity IDA 12929931 GO:0003713 transcription coactivator activity IDA contributes_to 12040021 14645221 23415232 GO:0004402 histone acetyltransferase activity IDA GO:0004402 histone acetyltransferase activity TAS 20019387 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IDA 1331501 8684459 9018065 9194564 9194565 9811832 9881977 9887100 10049825 10330164 10518217 10702269 10722728 10866661 11029584 11073990 11430825 11581164 11940655 12368347 12435739 12527917 12586840 12743606 12750254 12929931 14645221 14716005 14752053 15075319 15261140 15380363 15509808 15542844 15588252 15632193 15674325 15843474 15890677 16611888 16652169 16864582 16917507 17382325 17403783 17476304 17525731 17872950 17906639 18160048 18485870 18722353 19047049 19071119 19234109 19339993 19680224 20019387 20089040 20228809 20603618 20609350 20808282 20856196 21108945 21471221 21513714 21988832 22770219 23010591 23065768 23441852 23455922 23461825 23746844 23870121 23999430 24229708 24413532 24421387 24939902 25219498 25245946 25314079 GO:0005515 protein binding IPI 12408825 GO:0008013 beta-catenin binding IPI 17150957 GO:0008022 protein C-terminus binding IDA 8684459 11349124 15261140 GO:0008134 transcription factor binding IPI GO:0008270 zinc ion binding IEA 12456660 16135789 20228809 GO:0016407 acetyltransferase activity EXP 18722353 24939902 GO:0016407 acetyltransferase activity IDA 12435739 GO:0016407 acetyltransferase activity IMP 17403783 GO:0016746 transferase activity, transferring acyl groups IDA GO:0031490 chromatin DNA binding IEA GO:0032403 protein complex binding IEA 20590529 GO:0033613 activating transcription factor binding IPI GO:0034212 peptide N-acetyltransferase activity TAS 9862959 GO:0035257 nuclear hormone receptor binding IPI GO:0035259 glucocorticoid receptor binding IEA GO:0042975 peroxisome proliferator activated receptor binding IEA GO:0043425 bHLH transcription factor binding IEA GO:0046332 SMAD binding IEA 18487222 GO:0050681 androgen receptor binding IPI GO:0051019 mitogen-activated protein kinase binding IEA GO:0051059 NF-kappaB binding IEA GO:0097157 pre-mRNA intronic binding IEA GO:1990405 protein antigen binding IEA","hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04110 Cell cycle - Homo sapiens (human) hsa04310 Wnt signaling pathway - Homo sapiens (human) hsa04330 Notch signaling pathway - Homo sapiens (human) hsa04350 TGF-beta signaling pathway - Homo sapiens (human) hsa04520 Adherens junction - Homo sapiens (human) hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) hsa04720 Long-term potentiation - Homo sapiens (human) hsa04916 Melanogenesis - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04922 Glucagon signaling pathway - Homo sapiens (human) hsa05016 Huntington,s disease - Homo sapiens (human) hsa05152 Tuberculosis - Homo sapiens (human) hsa05161 Hepatitis B - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05166 HTLV-I infection - Homo sapiens (human) hsa05168 Herpes simplex infection - Homo sapiens (human) hsa05169 Epstein-Barr virus infection - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05211 Renal cell carcinoma - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human)",chemicalprobes.org I-CBP112,Q09472,Histone acetyltransferase p300,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2033,EP300,"Developmental Biology R-HSA-1266738 RORA activates gene expression R-HSA-1368082 Polo-like kinase mediated events R-HSA-156711 Signaling by NOTCH R-HSA-157118 Signal Transduction R-HSA-162582 Cell Cycle R-HSA-1640170 Disease R-HSA-1643685 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways R-HSA-168928 Cytosolic sensors of pathogen-associated DNA R-HSA-1834949 Signaling by Wnt R-HSA-195721 Signaling by NOTCH1 R-HSA-1980143 Signaling by NOTCH2 R-HSA-1980145 TCF dependent signaling in response to WNT R-HSA-201681 formation of the beta-catenin:TCF transactivating complex R-HSA-201722 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 NOTCH2 intracellular domain regulates transcription R-HSA-2197563 Cellular responses to stress R-HSA-2262752 Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 Signaling by NOTCH1 in Cancer R-HSA-2644603 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production R-HSA-3134973 HATs acetylate histones R-HSA-3214847 Chromatin modifying enzymes R-HSA-3247509 Cellular response to heat stress R-HSA-3371556 Attenuation phase R-HSA-3371568 HSF1-dependent transactivation R-HSA-3371571 Transcriptional regulation of white adipocyte differentiation R-HSA-381340 Circadian Clock R-HSA-400253 Mitotic G2-G2/M phases R-HSA-453274 Chromatin organization R-HSA-4839726 C-type lectin receptors (CLRs) R-HSA-5621481 CD209 (DC-SIGN) signaling R-HSA-5621575 Diseases of signal transduction R-HSA-5663202 G2/M Transition R-HSA-69275 Cell Cycle, Mitotic R-HSA-69278 TRAF3-dependent IRF activation pathway R-HSA-918233 TRAF6 mediated IRF7 activation R-HSA-933541",histone acetyltransferase complex GO:0000123 IEA chromatin GO:0000785 IEA nucleus GO:0005634 9194565 12929931 14645221 IDA nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS transcription factor complex GO:0005667 IEA cytoplasm GO:0005737 IDA protein-DNA complex GO:0032993 IEA,"negative regulation of transcription from RNA polymerase II promoter 10733570 GO:0000122 IDA response to hypoxia 9887100 15261140 GO:0001666 IDA somitogenesis GO:0001756 IEA liver development GO:0001889 IEA positive regulation of protein phosphorylation GO:0001934 IEA stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS transcription-coupled nucleotide-excision repair GO:0006283 TAS regulation of transcription, DNA-templated 15261140 GO:0006355 IDA transcription from RNA polymerase II promoter GO:0006366 IEA protein acetylation 21030595 24939902 GO:0006473 IDA protein acetylation 22013210 GO:0006473 TAS internal protein amino acid acetylation 18722353 GO:0006475 IDA apoptotic process 9194565 GO:0006915 IMP DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 TAS positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response GO:0006990 ISS Notch signaling pathway GO:0007219 TAS nervous system development 10205054 GO:0007399 TAS heart development GO:0007507 IEA skeletal muscle tissue development GO:0007519 IEA memory GO:0007613 IEA circadian rhythm GO:0007623 ISS organ morphogenesis GO:0009887 IEA regulation of autophagy 24852146 GO:0010506 TAS positive regulation of glycoprotein biosynthetic process GO:0010560 IEA positive regulation of cell death GO:0010942 IEA positive regulation of muscle atrophy GO:0014737 IEA viral process GO:0016032 IEA N-terminal peptidyl-lysine acetylation 12435739 GO:0018076 IDA internal peptidyl-lysine acetylation 17403783 GO:0018393 IDA B cell differentiation GO:0030183 IEA platelet formation GO:0030220 IEA lung development GO:0030324 IEA response to cobalt ion GO:0032025 IEA positive regulation of protein binding GO:0032092 IEA positive regulation of type I interferon production GO:0032481 TAS positive regulation of collagen biosynthetic process GO:0032967 IEA positive regulation of protein import into nucleus, translocation GO:0033160 IEA response to tumor necrosis factor GO:0034612 IEA cellular response to UV 24939902 GO:0034644 IDA positive regulation of histone acetylation GO:0035066 IEA cellular response to drug GO:0035690 IEA megakaryocyte development GO:0035855 IEA cellular response to trichostatin A GO:0035984 IEA intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 17403783 GO:0042771 IDA negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IEA positive regulation of DNA binding GO:0043388 IEA protein kinase B signaling GO:0043491 IEA response to estrogen 11581164 GO:0043627 IDA positive regulation by host of viral transcription 16687403 GO:0043923 IDA histone H3 acetylation GO:0043966 IEA histone H4 acetylation 16325578 GO:0043967 IMP histone H2B acetylation 23415232 GO:0043969 IDA fat cell differentiation GO:0045444 ISS response to ethanol GO:0045471 IEA positive regulation of translation GO:0045727 IEA positive regulation of axon extension GO:0045773 IEA positive regulation of cell size GO:0045793 IEA positive regulation of gene expression, epigenetic GO:0045815 TAS positive regulation of proteolysis GO:0045862 IEA positive regulation of transcription from RNA polymerase II promoter 12586840 18722353 GO:0045944 IDA positive regulation of transcription from RNA polymerase II promoter 16325578 GO:0045944 IMP digestive tract development GO:0048565 IEA positive regulation of protein secretion GO:0050714 IEA protein stabilization GO:0050821 ISS positive regulation of sequence-specific DNA binding transcription factor activity 10518217 GO:0051091 IDA response to calcium ion GO:0051592 IEA regulation of cell cycle GO:0051726 TAS regulation of angiotensin metabolic process GO:0060177 IEA positive regulation of sarcomere organization GO:0060298 IEA regulation of androgen receptor signaling pathway 18487222 GO:0060765 IDA regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 TAS protein-DNA complex assembly GO:0065004 IEA cellular response to hydrogen peroxide GO:0070301 IEA response to fatty acid GO:0070542 IEA cellular response to retinoic acid GO:0071300 IEA cellular response to cAMP GO:0071320 IEA cellular response to glucose stimulus GO:0071333 IEA cellular response to mineralocorticoid stimulus GO:0071389 IEA cellular response to dexamethasone stimulus GO:0071549 IEA regulation of tubulin deacetylation 18722353 GO:0090043 IDA regulation of cellular response to heat GO:1900034 TAS regulation of signal transduction by p53 class mediator GO:1901796 TAS beta-catenin-TCF complex assembly GO:1904837 TAS cellular response to nerve growth factor stimulus GO:1990090 IEA negative regulation of miRNA metabolic process GO:2000629 IEA","GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA 17641689 GO:0001047 core promoter binding IDA 20018936 GO:0001102 RNA polymerase II activating transcription factor binding IPI GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA GO:0002039 p53 binding IEA 9194565 GO:0003677 DNA binding IDA 24939902 GO:0003682 chromatin binding IDA 17641689 GO:0003682 chromatin binding IMP 24939902 GO:0003684 damaged DNA binding IDA 12435739 12586840 16687403 18487222 GO:0003713 transcription coactivator activity IDA 12929931 GO:0003713 transcription coactivator activity IDA contributes_to 12040021 14645221 23415232 GO:0004402 histone acetyltransferase activity IDA GO:0004402 histone acetyltransferase activity TAS 20019387 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor IDA 1331501 8684459 9018065 9194564 9194565 9811832 9881977 9887100 10049825 10330164 10518217 10702269 10722728 10866661 11029584 11073990 11430825 11581164 11940655 12368347 12435739 12527917 12586840 12743606 12750254 12929931 14645221 14716005 14752053 15075319 15261140 15380363 15509808 15542844 15588252 15632193 15674325 15843474 15890677 16611888 16652169 16864582 16917507 17382325 17403783 17476304 17525731 17872950 17906639 18160048 18485870 18722353 19047049 19071119 19234109 19339993 19680224 20019387 20089040 20228809 20603618 20609350 20808282 20856196 21108945 21471221 21513714 21988832 22770219 23010591 23065768 23441852 23455922 23461825 23746844 23870121 23999430 24229708 24413532 24421387 24939902 25219498 25245946 25314079 GO:0005515 protein binding IPI 12408825 GO:0008013 beta-catenin binding IPI 17150957 GO:0008022 protein C-terminus binding IDA 8684459 11349124 15261140 GO:0008134 transcription factor binding IPI GO:0008270 zinc ion binding IEA 12456660 16135789 20228809 GO:0016407 acetyltransferase activity EXP 18722353 24939902 GO:0016407 acetyltransferase activity IDA 12435739 GO:0016407 acetyltransferase activity IMP 17403783 GO:0016746 transferase activity, transferring acyl groups IDA GO:0031490 chromatin DNA binding IEA GO:0032403 protein complex binding IEA 20590529 GO:0033613 activating transcription factor binding IPI GO:0034212 peptide N-acetyltransferase activity TAS 9862959 GO:0035257 nuclear hormone receptor binding IPI GO:0035259 glucocorticoid receptor binding IEA GO:0042975 peroxisome proliferator activated receptor binding IEA GO:0043425 bHLH transcription factor binding IEA GO:0046332 SMAD binding IEA 18487222 GO:0050681 androgen receptor binding IPI GO:0051019 mitogen-activated protein kinase binding IEA GO:0051059 NF-kappaB binding IEA GO:0097157 pre-mRNA intronic binding IEA GO:1990405 protein antigen binding IEA","hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04110 Cell cycle - Homo sapiens (human) hsa04310 Wnt signaling pathway - Homo sapiens (human) hsa04330 Notch signaling pathway - Homo sapiens (human) hsa04350 TGF-beta signaling pathway - Homo sapiens (human) hsa04520 Adherens junction - Homo sapiens (human) hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) hsa04720 Long-term potentiation - Homo sapiens (human) hsa04916 Melanogenesis - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04922 Glucagon signaling pathway - Homo sapiens (human) hsa05016 Huntington,s disease - Homo sapiens (human) hsa05152 Tuberculosis - Homo sapiens (human) hsa05161 Hepatitis B - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05166 HTLV-I infection - Homo sapiens (human) hsa05168 Herpes simplex infection - Homo sapiens (human) hsa05169 Epstein-Barr virus infection - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05211 Renal cell carcinoma - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human)",chemicalprobes.org MS023,Q86X55,Histone-arginine methyltransferase CARM1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10498,CARM1,"R-HSA-1430728 Metabolism R-HSA-3214858 RMTs methylate histone arginines R-HSA-3247509 Chromatin modifying enzymes R-HSA-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-4839726 Chromatin organization R-HSA-535734 Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-556833 Metabolism of lipids and lipoproteins",nucleus IDA 15221992 GO:0005634 nucleoplasm IDA GO:0005654 nucleoplasm TAS GO:0005654 cytoplasm IDA 15221992 GO:0005737 cytosol IBA GO:0005829 cytosol ISS GO:0005829 RNA polymerase II transcription factor complex IEA GO:0090575,"regulation of growth plate cartilage chondrocyte proliferation GO:0003420 IEA transcription, DNA-templated GO:0006351 IEA regulation of transcription, DNA-templated GO:0006355 IBA regulation of transcription, DNA-templated GO:0006355 ISS DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 TAS aging GO:0007568 IEA positive regulation of cell proliferation GO:0008284 IEA viral process GO:0016032 IEA histone methylation GO:0016571 IDA 19405910 histone methylation GO:0016571 ISS peptidyl-arginine methylation, to asymmetrical-dimethyl arginine GO:0019919 IEA intracellular estrogen receptor signaling pathway GO:0030520 IEA negative regulation of protein binding GO:0032091 IEA regulation of intracellular estrogen receptor signaling pathway GO:0033146 ISS histone H3-R2 methylation GO:0034970 IMP 17898714 histone H3-R17 methylation GO:0034971 ISS cellular lipid metabolic process GO:0044255 TAS positive regulation of fat cell differentiation GO:0045600 ISS response to cAMP GO:0051591 IEA endochondral bone morphogenesis GO:0060350 IEA regulation of mRNA binding GO:1902415 IEA negative regulation of dendrite development GO:2000171 IEA",ISS GO:0003713 transcription coactivator activity 20111005 23455924 24434208 26267537 IPI GO:0005515 protein binding 16344550 TAS GO:0008013 beta-catenin binding ISS GO:0008276 protein methyltransferase activity 23980157 IDA GO:0008469 histone-arginine N-methyltransferase activity 18495660 IDA GO:0016274 protein-arginine N-methyltransferase activity ISS GO:0016274 protein-arginine N-methyltransferase activity TAS GO:0016274 protein-arginine N-methyltransferase activity ISS GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IBA GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity ISS GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity ISS GO:0035642 histone methyltransferase activity (H3-R17 specific) 19405910 IDA GO:0042054 histone methyltransferase activity IEA GO:0042803 protein homodimerization activity ISS GO:0044212 transcription regulatory region DNA binding ISS GO:0070577 lysine-acetylated histone binding,,chemicalprobes.org EPZ011989,Q92800,Histone-lysine N-methyltransferase EZH1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2145,EZH1,,GO:0005654 nucleoplasm IDA GO:0035098 ESC/E(Z) complex 20075857 IDA,"IEA GO:0006351 transcription, DNA-templated TAS 8921387 anatomical structure morphogenesis GO:0009653 IEA GO:0021766 hippocampus development IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0070734 histone H3-K27 methylation",chromatin binding GO:0003682 IEA histone-lysine N-methyltransferase activity GO:0018024 IEA,,chemicalprobes.org UNC1999,Q92800,Histone-lysine N-methyltransferase EZH1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2145,EZH1,,GO:0005654 nucleoplasm IDA GO:0035098 ESC/E(Z) complex 20075857 IDA,"IEA GO:0006351 transcription, DNA-templated TAS 8921387 anatomical structure morphogenesis GO:0009653 IEA GO:0021766 hippocampus development IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0070734 histone H3-K27 methylation",chromatin binding GO:0003682 IEA histone-lysine N-methyltransferase activity GO:0018024 IEA,,chemicalprobes.org EPZ-6438,Q15910,Histone-lysine N-methyltransferase EZH2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2146,EZH2,Epigenetic regulation of gene expression R-HSA-212165 PRC2 methylates histones and DNA R-HSA-212300 Cellular responses to stress R-HSA-2262752 Oxidative Stress Induced Senescence R-HSA-2559580 Cellular Senescence R-HSA-2559583 PKMTs methylate histone lysines R-HSA-3214841 Chromatin modifying enzymes R-HSA-3247509 Chromatin organization R-HSA-4839726 Gene Expression R-HSA-74160,nuclear chromatin GO:0000790 IDA 19734898 nucleus GO:0005634 IDA 19144645 nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 IDA ESC/E(Z) complex GO:0035098 IDA 15385962 20075857 23104054 23273982 24474760 pronucleus GO:0045120 IEA,"20154697 IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0006306 DNA methylation 8921387 TAS GO:0006325 chromatin organization IEA GO:0006351 transcription, DNA-templated 8921387 TAS GO:0006355 regulation of transcription, DNA-templated 20154697 IDA GO:0010718 positive regulation of epithelial to mesenchymal transition IEA GO:0014013 regulation of gliogenesis IEA GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA GO:0021695 cerebellar cortex development IEA GO:0021766 hippocampus development IEA GO:0032355 response to estradiol IEA GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IEA GO:0042127 regulation of cell proliferation 16717091 IMP GO:0042752 regulation of circadian rhythm 20154697 IDA GO:0043406 positive regulation of MAP kinase activity IEA GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity 20154697 IDA GO:0043547 positive regulation of GTPase activity IEA GO:0045605 negative regulation of epidermal cell differentiation 20154697 IDA GO:0045814 negative regulation of gene expression, epigenetic 24623306 IMP GO:0045814 negative regulation of gene expression, epigenetic TAS GO:0045814 negative regulation of gene expression, epigenetic 16179254 IMP GO:0045892 negative regulation of transcription, DNA-templated 16179254 IMP GO:0048387 negative regulation of retinoic acid receptor signaling pathway IEA GO:0048511 rhythmic process IEA GO:0051154 negative regulation of striated muscle cell differentiation IEA GO:0070301 cellular response to hydrogen peroxide IEA GO:0070314 G1 to G0 transition 24474760 IDA GO:0070734 histone H3-K27 methylation IEA GO:0071168 protein localization to chromatin 20154697 IDA GO:0071902 positive regulation of protein serine/threonine kinase activity IEA GO:1900006 positive regulation of dendrite development IEA GO:2000134 negative regulation of G1/S transition of mitotic cell cycle",core promoter binding GO:0001047 ISS DNA binding 8954776 GO:0003677 TAS chromatin binding 20154697 GO:0003682 IDA RNA binding GO:0003723 IEA protein binding 16179254 16357870 17560333 22009739 22094255 22439931 22483618 22897849 23455924 23684459 24074865 24474760 25416956 25417162 26496610 GO:0005515 IPI protein-lysine N-methyltransferase activity GO:0016279 TAS histone-lysine N-methyltransferase activity 19144645 GO:0018024 IDA histone-lysine N-methyltransferase activity GO:0018024 TAS chromatin DNA binding 19734898 GO:0031490 IDA histone methyltransferase activity 15385962 GO:0042054 IDA ribonucleoprotein complex binding GO:0043021 IEA sequence-specific DNA binding GO:0043565 IEA histone methyltransferase activity (H3-K27 specific) 24474760 GO:0046976 TAS promoter-specific chromatin binding 24623306 GO:1990841 IDA,MicroRNAs in cancer - Homo sapiens (human) hsa05206,chemicalprobes.org CPI-169,Q15910,Histone-lysine N-methyltransferase EZH2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2146,EZH2,Epigenetic regulation of gene expression R-HSA-212165 PRC2 methylates histones and DNA R-HSA-212300 Cellular responses to stress R-HSA-2262752 Oxidative Stress Induced Senescence R-HSA-2559580 Cellular Senescence R-HSA-2559583 PKMTs methylate histone lysines R-HSA-3214841 Chromatin modifying enzymes R-HSA-3247509 Chromatin organization R-HSA-4839726 Gene Expression R-HSA-74160,nuclear chromatin GO:0000790 IDA 19734898 nucleus GO:0005634 IDA 19144645 nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 IDA ESC/E(Z) complex GO:0035098 IDA 15385962 20075857 23104054 23273982 24474760 pronucleus GO:0045120 IEA,"20154697 IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0006306 DNA methylation 8921387 TAS GO:0006325 chromatin organization IEA GO:0006351 transcription, DNA-templated 8921387 TAS GO:0006355 regulation of transcription, DNA-templated 20154697 IDA GO:0010718 positive regulation of epithelial to mesenchymal transition IEA GO:0014013 regulation of gliogenesis IEA GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA GO:0021695 cerebellar cortex development IEA GO:0021766 hippocampus development IEA GO:0032355 response to estradiol IEA GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IEA GO:0042127 regulation of cell proliferation 16717091 IMP GO:0042752 regulation of circadian rhythm 20154697 IDA GO:0043406 positive regulation of MAP kinase activity IEA GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity 20154697 IDA GO:0043547 positive regulation of GTPase activity IEA GO:0045605 negative regulation of epidermal cell differentiation 20154697 IDA GO:0045814 negative regulation of gene expression, epigenetic 24623306 IMP GO:0045814 negative regulation of gene expression, epigenetic TAS GO:0045814 negative regulation of gene expression, epigenetic 16179254 IMP GO:0045892 negative regulation of transcription, DNA-templated 16179254 IMP GO:0048387 negative regulation of retinoic acid receptor signaling pathway IEA GO:0048511 rhythmic process IEA GO:0051154 negative regulation of striated muscle cell differentiation IEA GO:0070301 cellular response to hydrogen peroxide IEA GO:0070314 G1 to G0 transition 24474760 IDA GO:0070734 histone H3-K27 methylation IEA GO:0071168 protein localization to chromatin 20154697 IDA GO:0071902 positive regulation of protein serine/threonine kinase activity IEA GO:1900006 positive regulation of dendrite development IEA GO:2000134 negative regulation of G1/S transition of mitotic cell cycle",core promoter binding GO:0001047 ISS DNA binding 8954776 GO:0003677 TAS chromatin binding 20154697 GO:0003682 IDA RNA binding GO:0003723 IEA protein binding 16179254 16357870 17560333 22009739 22094255 22439931 22483618 22897849 23455924 23684459 24074865 24474760 25416956 25417162 26496610 GO:0005515 IPI protein-lysine N-methyltransferase activity GO:0016279 TAS histone-lysine N-methyltransferase activity 19144645 GO:0018024 IDA histone-lysine N-methyltransferase activity GO:0018024 TAS chromatin DNA binding 19734898 GO:0031490 IDA histone methyltransferase activity 15385962 GO:0042054 IDA ribonucleoprotein complex binding GO:0043021 IEA sequence-specific DNA binding GO:0043565 IEA histone methyltransferase activity (H3-K27 specific) 24474760 GO:0046976 TAS promoter-specific chromatin binding 24623306 GO:1990841 IDA,MicroRNAs in cancer - Homo sapiens (human) hsa05206,chemicalprobes.org EPZ011989,Q15910,Histone-lysine N-methyltransferase EZH2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2146,EZH2,Epigenetic regulation of gene expression R-HSA-212165 PRC2 methylates histones and DNA R-HSA-212300 Cellular responses to stress R-HSA-2262752 Oxidative Stress Induced Senescence R-HSA-2559580 Cellular Senescence R-HSA-2559583 PKMTs methylate histone lysines R-HSA-3214841 Chromatin modifying enzymes R-HSA-3247509 Chromatin organization R-HSA-4839726 Gene Expression R-HSA-74160,nuclear chromatin GO:0000790 IDA 19734898 nucleus GO:0005634 IDA 19144645 nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 IDA ESC/E(Z) complex GO:0035098 IDA 15385962 20075857 23104054 23273982 24474760 pronucleus GO:0045120 IEA,"20154697 IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0006306 DNA methylation 8921387 TAS GO:0006325 chromatin organization IEA GO:0006351 transcription, DNA-templated 8921387 TAS GO:0006355 regulation of transcription, DNA-templated 20154697 IDA GO:0010718 positive regulation of epithelial to mesenchymal transition IEA GO:0014013 regulation of gliogenesis IEA GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA GO:0021695 cerebellar cortex development IEA GO:0021766 hippocampus development IEA GO:0032355 response to estradiol IEA GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IEA GO:0042127 regulation of cell proliferation 16717091 IMP GO:0042752 regulation of circadian rhythm 20154697 IDA GO:0043406 positive regulation of MAP kinase activity IEA GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity 20154697 IDA GO:0043547 positive regulation of GTPase activity IEA GO:0045605 negative regulation of epidermal cell differentiation 20154697 IDA GO:0045814 negative regulation of gene expression, epigenetic 24623306 IMP GO:0045814 negative regulation of gene expression, epigenetic TAS GO:0045814 negative regulation of gene expression, epigenetic 16179254 IMP GO:0045892 negative regulation of transcription, DNA-templated 16179254 IMP GO:0048387 negative regulation of retinoic acid receptor signaling pathway IEA GO:0048511 rhythmic process IEA GO:0051154 negative regulation of striated muscle cell differentiation IEA GO:0070301 cellular response to hydrogen peroxide IEA GO:0070314 G1 to G0 transition 24474760 IDA GO:0070734 histone H3-K27 methylation IEA GO:0071168 protein localization to chromatin 20154697 IDA GO:0071902 positive regulation of protein serine/threonine kinase activity IEA GO:1900006 positive regulation of dendrite development IEA GO:2000134 negative regulation of G1/S transition of mitotic cell cycle",core promoter binding GO:0001047 ISS DNA binding 8954776 GO:0003677 TAS chromatin binding 20154697 GO:0003682 IDA RNA binding GO:0003723 IEA protein binding 16179254 16357870 17560333 22009739 22094255 22439931 22483618 22897849 23455924 23684459 24074865 24474760 25416956 25417162 26496610 GO:0005515 IPI protein-lysine N-methyltransferase activity GO:0016279 TAS histone-lysine N-methyltransferase activity 19144645 GO:0018024 IDA histone-lysine N-methyltransferase activity GO:0018024 TAS chromatin DNA binding 19734898 GO:0031490 IDA histone methyltransferase activity 15385962 GO:0042054 IDA ribonucleoprotein complex binding GO:0043021 IEA sequence-specific DNA binding GO:0043565 IEA histone methyltransferase activity (H3-K27 specific) 24474760 GO:0046976 TAS promoter-specific chromatin binding 24623306 GO:1990841 IDA,MicroRNAs in cancer - Homo sapiens (human) hsa05206,chemicalprobes.org GSK343,Q15910,Histone-lysine N-methyltransferase EZH2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2146,EZH2,Epigenetic regulation of gene expression R-HSA-212165 PRC2 methylates histones and DNA R-HSA-212300 Cellular responses to stress R-HSA-2262752 Oxidative Stress Induced Senescence R-HSA-2559580 Cellular Senescence R-HSA-2559583 PKMTs methylate histone lysines R-HSA-3214841 Chromatin modifying enzymes R-HSA-3247509 Chromatin organization R-HSA-4839726 Gene Expression R-HSA-74160,nuclear chromatin GO:0000790 IDA 19734898 nucleus GO:0005634 IDA 19144645 nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 IDA ESC/E(Z) complex GO:0035098 IDA 15385962 20075857 23104054 23273982 24474760 pronucleus GO:0045120 IEA,"20154697 IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0006306 DNA methylation 8921387 TAS GO:0006325 chromatin organization IEA GO:0006351 transcription, DNA-templated 8921387 TAS GO:0006355 regulation of transcription, DNA-templated 20154697 IDA GO:0010718 positive regulation of epithelial to mesenchymal transition IEA GO:0014013 regulation of gliogenesis IEA GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA GO:0021695 cerebellar cortex development IEA GO:0021766 hippocampus development IEA GO:0032355 response to estradiol IEA GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IEA GO:0042127 regulation of cell proliferation 16717091 IMP GO:0042752 regulation of circadian rhythm 20154697 IDA GO:0043406 positive regulation of MAP kinase activity IEA GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity 20154697 IDA GO:0043547 positive regulation of GTPase activity IEA GO:0045605 negative regulation of epidermal cell differentiation 20154697 IDA GO:0045814 negative regulation of gene expression, epigenetic 24623306 IMP GO:0045814 negative regulation of gene expression, epigenetic TAS GO:0045814 negative regulation of gene expression, epigenetic 16179254 IMP GO:0045892 negative regulation of transcription, DNA-templated 16179254 IMP GO:0048387 negative regulation of retinoic acid receptor signaling pathway IEA GO:0048511 rhythmic process IEA GO:0051154 negative regulation of striated muscle cell differentiation IEA GO:0070301 cellular response to hydrogen peroxide IEA GO:0070314 G1 to G0 transition 24474760 IDA GO:0070734 histone H3-K27 methylation IEA GO:0071168 protein localization to chromatin 20154697 IDA GO:0071902 positive regulation of protein serine/threonine kinase activity IEA GO:1900006 positive regulation of dendrite development IEA GO:2000134 negative regulation of G1/S transition of mitotic cell cycle",core promoter binding GO:0001047 ISS DNA binding 8954776 GO:0003677 TAS chromatin binding 20154697 GO:0003682 IDA RNA binding GO:0003723 IEA protein binding 16179254 16357870 17560333 22009739 22094255 22439931 22483618 22897849 23455924 23684459 24074865 24474760 25416956 25417162 26496610 GO:0005515 IPI protein-lysine N-methyltransferase activity GO:0016279 TAS histone-lysine N-methyltransferase activity 19144645 GO:0018024 IDA histone-lysine N-methyltransferase activity GO:0018024 TAS chromatin DNA binding 19734898 GO:0031490 IDA histone methyltransferase activity 15385962 GO:0042054 IDA ribonucleoprotein complex binding GO:0043021 IEA sequence-specific DNA binding GO:0043565 IEA histone methyltransferase activity (H3-K27 specific) 24474760 GO:0046976 TAS promoter-specific chromatin binding 24623306 GO:1990841 IDA,MicroRNAs in cancer - Homo sapiens (human) hsa05206,chemicalprobes.org UNC1999,Q15910,Histone-lysine N-methyltransferase EZH2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2146,EZH2,Epigenetic regulation of gene expression R-HSA-212165 PRC2 methylates histones and DNA R-HSA-212300 Cellular responses to stress R-HSA-2262752 Oxidative Stress Induced Senescence R-HSA-2559580 Cellular Senescence R-HSA-2559583 PKMTs methylate histone lysines R-HSA-3214841 Chromatin modifying enzymes R-HSA-3247509 Chromatin organization R-HSA-4839726 Gene Expression R-HSA-74160,nuclear chromatin GO:0000790 IDA 19734898 nucleus GO:0005634 IDA 19144645 nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 IDA ESC/E(Z) complex GO:0035098 IDA 15385962 20075857 23104054 23273982 24474760 pronucleus GO:0045120 IEA,"20154697 IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0006306 DNA methylation 8921387 TAS GO:0006325 chromatin organization IEA GO:0006351 transcription, DNA-templated 8921387 TAS GO:0006355 regulation of transcription, DNA-templated 20154697 IDA GO:0010718 positive regulation of epithelial to mesenchymal transition IEA GO:0014013 regulation of gliogenesis IEA GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA GO:0021695 cerebellar cortex development IEA GO:0021766 hippocampus development IEA GO:0032355 response to estradiol IEA GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IEA GO:0042127 regulation of cell proliferation 16717091 IMP GO:0042752 regulation of circadian rhythm 20154697 IDA GO:0043406 positive regulation of MAP kinase activity IEA GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity 20154697 IDA GO:0043547 positive regulation of GTPase activity IEA GO:0045605 negative regulation of epidermal cell differentiation 20154697 IDA GO:0045814 negative regulation of gene expression, epigenetic 24623306 IMP GO:0045814 negative regulation of gene expression, epigenetic TAS GO:0045814 negative regulation of gene expression, epigenetic 16179254 IMP GO:0045892 negative regulation of transcription, DNA-templated 16179254 IMP GO:0048387 negative regulation of retinoic acid receptor signaling pathway IEA GO:0048511 rhythmic process IEA GO:0051154 negative regulation of striated muscle cell differentiation IEA GO:0070301 cellular response to hydrogen peroxide IEA GO:0070314 G1 to G0 transition 24474760 IDA GO:0070734 histone H3-K27 methylation IEA GO:0071168 protein localization to chromatin 20154697 IDA GO:0071902 positive regulation of protein serine/threonine kinase activity IEA GO:1900006 positive regulation of dendrite development IEA GO:2000134 negative regulation of G1/S transition of mitotic cell cycle",core promoter binding GO:0001047 ISS DNA binding 8954776 GO:0003677 TAS chromatin binding 20154697 GO:0003682 IDA RNA binding GO:0003723 IEA protein binding 16179254 16357870 17560333 22009739 22094255 22439931 22483618 22897849 23455924 23684459 24074865 24474760 25416956 25417162 26496610 GO:0005515 IPI protein-lysine N-methyltransferase activity GO:0016279 TAS histone-lysine N-methyltransferase activity 19144645 GO:0018024 IDA histone-lysine N-methyltransferase activity GO:0018024 TAS chromatin DNA binding 19734898 GO:0031490 IDA histone methyltransferase activity 15385962 GO:0042054 IDA ribonucleoprotein complex binding GO:0043021 IEA sequence-specific DNA binding GO:0043565 IEA histone methyltransferase activity (H3-K27 specific) 24474760 GO:0046976 TAS promoter-specific chromatin binding 24623306 GO:1990841 IDA,MicroRNAs in cancer - Homo sapiens (human) hsa05206,chemicalprobes.org JQEZ5,Q15910,Histone-lysine N-methyltransferase EZH2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2146,EZH2,Epigenetic regulation of gene expression R-HSA-212165 PRC2 methylates histones and DNA R-HSA-212300 Cellular responses to stress R-HSA-2262752 Oxidative Stress Induced Senescence R-HSA-2559580 Cellular Senescence R-HSA-2559583 PKMTs methylate histone lysines R-HSA-3214841 Chromatin modifying enzymes R-HSA-3247509 Chromatin organization R-HSA-4839726 Gene Expression R-HSA-74160,nuclear chromatin GO:0000790 IDA 19734898 nucleus GO:0005634 IDA 19144645 nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 IDA ESC/E(Z) complex GO:0035098 IDA 15385962 20075857 23104054 23273982 24474760 pronucleus GO:0045120 IEA,"20154697 IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0006306 DNA methylation 8921387 TAS GO:0006325 chromatin organization IEA GO:0006351 transcription, DNA-templated 8921387 TAS GO:0006355 regulation of transcription, DNA-templated 20154697 IDA GO:0010718 positive regulation of epithelial to mesenchymal transition IEA GO:0014013 regulation of gliogenesis IEA GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA GO:0021695 cerebellar cortex development IEA GO:0021766 hippocampus development IEA GO:0032355 response to estradiol IEA GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IEA GO:0042127 regulation of cell proliferation 16717091 IMP GO:0042752 regulation of circadian rhythm 20154697 IDA GO:0043406 positive regulation of MAP kinase activity IEA GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity 20154697 IDA GO:0043547 positive regulation of GTPase activity IEA GO:0045605 negative regulation of epidermal cell differentiation 20154697 IDA GO:0045814 negative regulation of gene expression, epigenetic 24623306 IMP GO:0045814 negative regulation of gene expression, epigenetic TAS GO:0045814 negative regulation of gene expression, epigenetic 16179254 IMP GO:0045892 negative regulation of transcription, DNA-templated 16179254 IMP GO:0048387 negative regulation of retinoic acid receptor signaling pathway IEA GO:0048511 rhythmic process IEA GO:0051154 negative regulation of striated muscle cell differentiation IEA GO:0070301 cellular response to hydrogen peroxide IEA GO:0070314 G1 to G0 transition 24474760 IDA GO:0070734 histone H3-K27 methylation IEA GO:0071168 protein localization to chromatin 20154697 IDA GO:0071902 positive regulation of protein serine/threonine kinase activity IEA GO:1900006 positive regulation of dendrite development IEA GO:2000134 negative regulation of G1/S transition of mitotic cell cycle",core promoter binding GO:0001047 ISS DNA binding 8954776 GO:0003677 TAS chromatin binding 20154697 GO:0003682 IDA RNA binding GO:0003723 IEA protein binding 16179254 16357870 17560333 22009739 22094255 22439931 22483618 22897849 23455924 23684459 24074865 24474760 25416956 25417162 26496610 GO:0005515 IPI protein-lysine N-methyltransferase activity GO:0016279 TAS histone-lysine N-methyltransferase activity 19144645 GO:0018024 IDA histone-lysine N-methyltransferase activity GO:0018024 TAS chromatin DNA binding 19734898 GO:0031490 IDA histone methyltransferase activity 15385962 GO:0042054 IDA ribonucleoprotein complex binding GO:0043021 IEA sequence-specific DNA binding GO:0043565 IEA histone methyltransferase activity (H3-K27 specific) 24474760 GO:0046976 TAS promoter-specific chromatin binding 24623306 GO:1990841 IDA,MicroRNAs in cancer - Homo sapiens (human) hsa05206,chemicalprobes.org EI1,Q15910,Histone-lysine N-methyltransferase EZH2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2146,EZH2,Epigenetic regulation of gene expression R-HSA-212165 PRC2 methylates histones and DNA R-HSA-212300 Cellular responses to stress R-HSA-2262752 Oxidative Stress Induced Senescence R-HSA-2559580 Cellular Senescence R-HSA-2559583 PKMTs methylate histone lysines R-HSA-3214841 Chromatin modifying enzymes R-HSA-3247509 Chromatin organization R-HSA-4839726 Gene Expression R-HSA-74160,nuclear chromatin GO:0000790 IDA 19734898 nucleus GO:0005634 IDA 19144645 nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 IDA ESC/E(Z) complex GO:0035098 IDA 15385962 20075857 23104054 23273982 24474760 pronucleus GO:0045120 IEA,"20154697 IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0006306 DNA methylation 8921387 TAS GO:0006325 chromatin organization IEA GO:0006351 transcription, DNA-templated 8921387 TAS GO:0006355 regulation of transcription, DNA-templated 20154697 IDA GO:0010718 positive regulation of epithelial to mesenchymal transition IEA GO:0014013 regulation of gliogenesis IEA GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA GO:0021695 cerebellar cortex development IEA GO:0021766 hippocampus development IEA GO:0032355 response to estradiol IEA GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IEA GO:0042127 regulation of cell proliferation 16717091 IMP GO:0042752 regulation of circadian rhythm 20154697 IDA GO:0043406 positive regulation of MAP kinase activity IEA GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity 20154697 IDA GO:0043547 positive regulation of GTPase activity IEA GO:0045605 negative regulation of epidermal cell differentiation 20154697 IDA GO:0045814 negative regulation of gene expression, epigenetic 24623306 IMP GO:0045814 negative regulation of gene expression, epigenetic TAS GO:0045814 negative regulation of gene expression, epigenetic 16179254 IMP GO:0045892 negative regulation of transcription, DNA-templated 16179254 IMP GO:0048387 negative regulation of retinoic acid receptor signaling pathway IEA GO:0048511 rhythmic process IEA GO:0051154 negative regulation of striated muscle cell differentiation IEA GO:0070301 cellular response to hydrogen peroxide IEA GO:0070314 G1 to G0 transition 24474760 IDA GO:0070734 histone H3-K27 methylation IEA GO:0071168 protein localization to chromatin 20154697 IDA GO:0071902 positive regulation of protein serine/threonine kinase activity IEA GO:1900006 positive regulation of dendrite development IEA GO:2000134 negative regulation of G1/S transition of mitotic cell cycle",core promoter binding GO:0001047 ISS DNA binding 8954776 GO:0003677 TAS chromatin binding 20154697 GO:0003682 IDA RNA binding GO:0003723 IEA protein binding 16179254 16357870 17560333 22009739 22094255 22439931 22483618 22897849 23455924 23684459 24074865 24474760 25416956 25417162 26496610 GO:0005515 IPI protein-lysine N-methyltransferase activity GO:0016279 TAS histone-lysine N-methyltransferase activity 19144645 GO:0018024 IDA histone-lysine N-methyltransferase activity GO:0018024 TAS chromatin DNA binding 19734898 GO:0031490 IDA histone methyltransferase activity 15385962 GO:0042054 IDA ribonucleoprotein complex binding GO:0043021 IEA sequence-specific DNA binding GO:0043565 IEA histone methyltransferase activity (H3-K27 specific) 24474760 GO:0046976 TAS promoter-specific chromatin binding 24623306 GO:1990841 IDA,MicroRNAs in cancer - Homo sapiens (human) hsa05206,chemicalprobes.org CPI-360,Q15910,Histone-lysine N-methyltransferase EZH2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2146,EZH2,Epigenetic regulation of gene expression R-HSA-212165 PRC2 methylates histones and DNA R-HSA-212300 Cellular responses to stress R-HSA-2262752 Oxidative Stress Induced Senescence R-HSA-2559580 Cellular Senescence R-HSA-2559583 PKMTs methylate histone lysines R-HSA-3214841 Chromatin modifying enzymes R-HSA-3247509 Chromatin organization R-HSA-4839726 Gene Expression R-HSA-74160,nuclear chromatin GO:0000790 IDA 19734898 nucleus GO:0005634 IDA 19144645 nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 IDA ESC/E(Z) complex GO:0035098 IDA 15385962 20075857 23104054 23273982 24474760 pronucleus GO:0045120 IEA,"20154697 IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0006306 DNA methylation 8921387 TAS GO:0006325 chromatin organization IEA GO:0006351 transcription, DNA-templated 8921387 TAS GO:0006355 regulation of transcription, DNA-templated 20154697 IDA GO:0010718 positive regulation of epithelial to mesenchymal transition IEA GO:0014013 regulation of gliogenesis IEA GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA GO:0021695 cerebellar cortex development IEA GO:0021766 hippocampus development IEA GO:0032355 response to estradiol IEA GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IEA GO:0042127 regulation of cell proliferation 16717091 IMP GO:0042752 regulation of circadian rhythm 20154697 IDA GO:0043406 positive regulation of MAP kinase activity IEA GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity 20154697 IDA GO:0043547 positive regulation of GTPase activity IEA GO:0045605 negative regulation of epidermal cell differentiation 20154697 IDA GO:0045814 negative regulation of gene expression, epigenetic 24623306 IMP GO:0045814 negative regulation of gene expression, epigenetic TAS GO:0045814 negative regulation of gene expression, epigenetic 16179254 IMP GO:0045892 negative regulation of transcription, DNA-templated 16179254 IMP GO:0048387 negative regulation of retinoic acid receptor signaling pathway IEA GO:0048511 rhythmic process IEA GO:0051154 negative regulation of striated muscle cell differentiation IEA GO:0070301 cellular response to hydrogen peroxide IEA GO:0070314 G1 to G0 transition 24474760 IDA GO:0070734 histone H3-K27 methylation IEA GO:0071168 protein localization to chromatin 20154697 IDA GO:0071902 positive regulation of protein serine/threonine kinase activity IEA GO:1900006 positive regulation of dendrite development IEA GO:2000134 negative regulation of G1/S transition of mitotic cell cycle",core promoter binding GO:0001047 ISS DNA binding 8954776 GO:0003677 TAS chromatin binding 20154697 GO:0003682 IDA RNA binding GO:0003723 IEA protein binding 16179254 16357870 17560333 22009739 22094255 22439931 22483618 22897849 23455924 23684459 24074865 24474760 25416956 25417162 26496610 GO:0005515 IPI protein-lysine N-methyltransferase activity GO:0016279 TAS histone-lysine N-methyltransferase activity 19144645 GO:0018024 IDA histone-lysine N-methyltransferase activity GO:0018024 TAS chromatin DNA binding 19734898 GO:0031490 IDA histone methyltransferase activity 15385962 GO:0042054 IDA ribonucleoprotein complex binding GO:0043021 IEA sequence-specific DNA binding GO:0043565 IEA histone methyltransferase activity (H3-K27 specific) 24474760 GO:0046976 TAS promoter-specific chromatin binding 24623306 GO:1990841 IDA,MicroRNAs in cancer - Homo sapiens (human) hsa05206,chemicalprobes.org UNC0642,Q15910,Histone-lysine N-methyltransferase EZH2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2146,EZH2,Epigenetic regulation of gene expression R-HSA-212165 PRC2 methylates histones and DNA R-HSA-212300 Cellular responses to stress R-HSA-2262752 Oxidative Stress Induced Senescence R-HSA-2559580 Cellular Senescence R-HSA-2559583 PKMTs methylate histone lysines R-HSA-3214841 Chromatin modifying enzymes R-HSA-3247509 Chromatin organization R-HSA-4839726 Gene Expression R-HSA-74160,nuclear chromatin GO:0000790 IDA 19734898 nucleus GO:0005634 IDA 19144645 nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 IDA ESC/E(Z) complex GO:0035098 IDA 15385962 20075857 23104054 23273982 24474760 pronucleus GO:0045120 IEA,"20154697 IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0006306 DNA methylation 8921387 TAS GO:0006325 chromatin organization IEA GO:0006351 transcription, DNA-templated 8921387 TAS GO:0006355 regulation of transcription, DNA-templated 20154697 IDA GO:0010718 positive regulation of epithelial to mesenchymal transition IEA GO:0014013 regulation of gliogenesis IEA GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA GO:0021695 cerebellar cortex development IEA GO:0021766 hippocampus development IEA GO:0032355 response to estradiol IEA GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IEA GO:0042127 regulation of cell proliferation 16717091 IMP GO:0042752 regulation of circadian rhythm 20154697 IDA GO:0043406 positive regulation of MAP kinase activity IEA GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity 20154697 IDA GO:0043547 positive regulation of GTPase activity IEA GO:0045605 negative regulation of epidermal cell differentiation 20154697 IDA GO:0045814 negative regulation of gene expression, epigenetic 24623306 IMP GO:0045814 negative regulation of gene expression, epigenetic TAS GO:0045814 negative regulation of gene expression, epigenetic 16179254 IMP GO:0045892 negative regulation of transcription, DNA-templated 16179254 IMP GO:0048387 negative regulation of retinoic acid receptor signaling pathway IEA GO:0048511 rhythmic process IEA GO:0051154 negative regulation of striated muscle cell differentiation IEA GO:0070301 cellular response to hydrogen peroxide IEA GO:0070314 G1 to G0 transition 24474760 IDA GO:0070734 histone H3-K27 methylation IEA GO:0071168 protein localization to chromatin 20154697 IDA GO:0071902 positive regulation of protein serine/threonine kinase activity IEA GO:1900006 positive regulation of dendrite development IEA GO:2000134 negative regulation of G1/S transition of mitotic cell cycle",core promoter binding GO:0001047 ISS DNA binding 8954776 GO:0003677 TAS chromatin binding 20154697 GO:0003682 IDA RNA binding GO:0003723 IEA protein binding 16179254 16357870 17560333 22009739 22094255 22439931 22483618 22897849 23455924 23684459 24074865 24474760 25416956 25417162 26496610 GO:0005515 IPI protein-lysine N-methyltransferase activity GO:0016279 TAS histone-lysine N-methyltransferase activity 19144645 GO:0018024 IDA histone-lysine N-methyltransferase activity GO:0018024 TAS chromatin DNA binding 19734898 GO:0031490 IDA histone methyltransferase activity 15385962 GO:0042054 IDA ribonucleoprotein complex binding GO:0043021 IEA sequence-specific DNA binding GO:0043565 IEA histone methyltransferase activity (H3-K27 specific) 24474760 GO:0046976 TAS promoter-specific chromatin binding 24623306 GO:1990841 IDA,MicroRNAs in cancer - Homo sapiens (human) hsa05206,chemicalprobes.org EPZ-5676,Q8TEK3,"Histone-lysine N-methyltransferase, H3 lysine-79 specific",0.0,NA,NA,NA,NA,NA,NA,NA,NULL,84444,DOT1L,R-HSA-3214841 PKMTs methylate histone lysines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization,GO:0005654 nucleoplasm IDA GO:0005654 nucleoplasm TAS,GO:0006342 chromatin silencing IEA GO:0032200 telomere organization 17675446 TAS GO:0034729 histone H3-K79 methylation IEA GO:0046425 regulation of JAK-STAT cascade 22002246 IDA GO:0051726 regulation of cell cycle IEA GO:2000677 regulation of transcription regulatory region DNA binding 22002246 IMP,IEA GO:0003677 DNA binding IPI 20153263 20203130 26496610 protein binding GO:0005515 IDA 17707234 histone-lysine N-methyltransferase activity GO:0018024 TAS GO:0018024 histone-lysine N-methyltransferase activity IEA GO:0031151 histone methyltransferase activity (H3-K79 specific),Lysine degradation - Homo sapiens (human) hsa00310 Transcriptional misregulation in cancer - Homo sapiens (human) hsa05202,chemicalprobes.org SGC0946,Q8TEK3,"Histone-lysine N-methyltransferase, H3 lysine-79 specific",0.0,NA,NA,NA,NA,NA,NA,NA,NULL,84444,DOT1L,R-HSA-3214841 PKMTs methylate histone lysines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization,GO:0005654 nucleoplasm IDA GO:0005654 nucleoplasm TAS,GO:0006342 chromatin silencing IEA GO:0032200 telomere organization 17675446 TAS GO:0034729 histone H3-K79 methylation IEA GO:0046425 regulation of JAK-STAT cascade 22002246 IDA GO:0051726 regulation of cell cycle IEA GO:2000677 regulation of transcription regulatory region DNA binding 22002246 IMP,IEA GO:0003677 DNA binding IPI 20153263 20203130 26496610 protein binding GO:0005515 IDA 17707234 histone-lysine N-methyltransferase activity GO:0018024 TAS GO:0018024 histone-lysine N-methyltransferase activity IEA GO:0031151 histone methyltransferase activity (H3-K79 specific),Lysine degradation - Homo sapiens (human) hsa00310 Transcriptional misregulation in cancer - Homo sapiens (human) hsa05202,chemicalprobes.org EPZ004777,Q8TEK3,"Histone-lysine N-methyltransferase, H3 lysine-79 specific",0.0,NA,NA,NA,NA,NA,NA,NA,NULL,84444,DOT1L,R-HSA-3214841 PKMTs methylate histone lysines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization,GO:0005654 nucleoplasm IDA GO:0005654 nucleoplasm TAS,GO:0006342 chromatin silencing IEA GO:0032200 telomere organization 17675446 TAS GO:0034729 histone H3-K79 methylation IEA GO:0046425 regulation of JAK-STAT cascade 22002246 IDA GO:0051726 regulation of cell cycle IEA GO:2000677 regulation of transcription regulatory region DNA binding 22002246 IMP,IEA GO:0003677 DNA binding IPI 20153263 20203130 26496610 protein binding GO:0005515 IDA 17707234 histone-lysine N-methyltransferase activity GO:0018024 TAS GO:0018024 histone-lysine N-methyltransferase activity IEA GO:0031151 histone methyltransferase activity (H3-K79 specific),Lysine degradation - Homo sapiens (human) hsa00310 Transcriptional misregulation in cancer - Homo sapiens (human) hsa05202,chemicalprobes.org A-366,Q96KQ7,"Histone-lysine N-methyltransferase, H3 lysine-9 specific 3",0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10919,EHMT2,"R-HSA-2262752 Cellular responses to stress R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559583 Cellular Senescence R-HSA-3214841 PKMTs methylate histone lysines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization R-HSA-504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-73762 RNA Polymerase I Transcription Initiation R-HSA-73854 RNA Polymerase I Promoter Clearance R-HSA-73864 RNA Polymerase I Transcription R-HSA-74159 Transcription R-HSA-74160 Gene Expression",19144645 GO:0000790 nuclear chromatin IDA 19144645 GO:0005634 nucleus IDA GO:0005634 nucleus ISS GO:0005654 nucleoplasm IDA GO:0005654 nucleoplasm TAS,GO:0000122 negative regulation of transcription from RNA polymerase II promoter 19144645 IDA GO:0006275 regulation of DNA replication 22387026 IMP GO:0006306 DNA methylation ISS GO:0009267 cellular response to starvation 23918802 IDA GO:0016571 histone methylation 22387026 IMP GO:0018027 peptidyl-lysine dimethylation 20118233 IDA GO:0034968 histone lysine methylation 19144645 IDA GO:0051567 histone H3-K9 methylation IEA GO:0070734 histone H3-K27 methylation IEA GO:1901796 regulation of signal transduction by p53 class mediator TAS,IPI 20118233 p53 binding GO:0002039 IPI 16189514 16287849 17636019 18451879 19061646 21549307 23752268 24492005 26028330 protein binding GO:0005515 IEA GO:0008270 zinc ion binding IDA 20118233 protein-lysine N-methyltransferase activity GO:0016279 IDA 19144645 histone-lysine N-methyltransferase activity GO:0018024 IMP 22387026 histone-lysine N-methyltransferase activity GO:0018024 ISS GO:0046974 histone methyltransferase activity (H3-K9 specific) ISS GO:0046976 histone methyltransferase activity (H3-K27 specific) IPI 16702210 C2H2 zinc finger domain binding GO:0070742 IDA 23918802 promoter-specific chromatin binding GO:1990841,hsa00310 Lysine degradation - Homo sapiens (human),chemicalprobes.org UNC0638,Q96KQ7,"Histone-lysine N-methyltransferase, H3 lysine-9 specific 3",0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10919,EHMT2,"R-HSA-2262752 Cellular responses to stress R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559583 Cellular Senescence R-HSA-3214841 PKMTs methylate histone lysines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization R-HSA-504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-73762 RNA Polymerase I Transcription Initiation R-HSA-73854 RNA Polymerase I Promoter Clearance R-HSA-73864 RNA Polymerase I Transcription R-HSA-74159 Transcription R-HSA-74160 Gene Expression",19144645 GO:0000790 nuclear chromatin IDA 19144645 GO:0005634 nucleus IDA GO:0005634 nucleus ISS GO:0005654 nucleoplasm IDA GO:0005654 nucleoplasm TAS,GO:0000122 negative regulation of transcription from RNA polymerase II promoter 19144645 IDA GO:0006275 regulation of DNA replication 22387026 IMP GO:0006306 DNA methylation ISS GO:0009267 cellular response to starvation 23918802 IDA GO:0016571 histone methylation 22387026 IMP GO:0018027 peptidyl-lysine dimethylation 20118233 IDA GO:0034968 histone lysine methylation 19144645 IDA GO:0051567 histone H3-K9 methylation IEA GO:0070734 histone H3-K27 methylation IEA GO:1901796 regulation of signal transduction by p53 class mediator TAS,IPI 20118233 p53 binding GO:0002039 IPI 16189514 16287849 17636019 18451879 19061646 21549307 23752268 24492005 26028330 protein binding GO:0005515 IEA GO:0008270 zinc ion binding IDA 20118233 protein-lysine N-methyltransferase activity GO:0016279 IDA 19144645 histone-lysine N-methyltransferase activity GO:0018024 IMP 22387026 histone-lysine N-methyltransferase activity GO:0018024 ISS GO:0046974 histone methyltransferase activity (H3-K9 specific) ISS GO:0046976 histone methyltransferase activity (H3-K27 specific) IPI 16702210 C2H2 zinc finger domain binding GO:0070742 IDA 23918802 promoter-specific chromatin binding GO:1990841,hsa00310 Lysine degradation - Homo sapiens (human),chemicalprobes.org BIX-01294,Q96KQ7,"Histone-lysine N-methyltransferase, H3 lysine-9 specific 3",0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10919,EHMT2,"R-HSA-2262752 Cellular responses to stress R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559583 Cellular Senescence R-HSA-3214841 PKMTs methylate histone lysines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization R-HSA-504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-73762 RNA Polymerase I Transcription Initiation R-HSA-73854 RNA Polymerase I Promoter Clearance R-HSA-73864 RNA Polymerase I Transcription R-HSA-74159 Transcription R-HSA-74160 Gene Expression",19144645 GO:0000790 nuclear chromatin IDA 19144645 GO:0005634 nucleus IDA GO:0005634 nucleus ISS GO:0005654 nucleoplasm IDA GO:0005654 nucleoplasm TAS,GO:0000122 negative regulation of transcription from RNA polymerase II promoter 19144645 IDA GO:0006275 regulation of DNA replication 22387026 IMP GO:0006306 DNA methylation ISS GO:0009267 cellular response to starvation 23918802 IDA GO:0016571 histone methylation 22387026 IMP GO:0018027 peptidyl-lysine dimethylation 20118233 IDA GO:0034968 histone lysine methylation 19144645 IDA GO:0051567 histone H3-K9 methylation IEA GO:0070734 histone H3-K27 methylation IEA GO:1901796 regulation of signal transduction by p53 class mediator TAS,IPI 20118233 p53 binding GO:0002039 IPI 16189514 16287849 17636019 18451879 19061646 21549307 23752268 24492005 26028330 protein binding GO:0005515 IEA GO:0008270 zinc ion binding IDA 20118233 protein-lysine N-methyltransferase activity GO:0016279 IDA 19144645 histone-lysine N-methyltransferase activity GO:0018024 IMP 22387026 histone-lysine N-methyltransferase activity GO:0018024 ISS GO:0046974 histone methyltransferase activity (H3-K9 specific) ISS GO:0046976 histone methyltransferase activity (H3-K27 specific) IPI 16702210 C2H2 zinc finger domain binding GO:0070742 IDA 23918802 promoter-specific chromatin binding GO:1990841,hsa00310 Lysine degradation - Homo sapiens (human),chemicalprobes.org A-366,Q9H9B1,"Histone-lysine N-methyltransferase, H3 lysine-9 specific 5",0.0,NA,NA,NA,NA,NA,NA,NA,NULL,79813,EHMT1,R-HSA-2262752 Cellular responses to stress R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559583 Cellular Senescence R-HSA-3214841 PKMTs methylate histone lysines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization,nucleus IC 12004135 GO:0005634 nucleus IDA 19144645 GO:0005634 nucleus ISS GO:0005634 nucleoplasm IDA GO:0005654 nucleoplasm TAS GO:0005654 chromosome IEA GO:0005694,"negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA DNA methylation GO:0006306 ISS embryo development GO:0009790 ISS chromatin modification GO:0016568 IDA 12004135 histone methylation GO:0016571 IDA 12004135 peptidyl-lysine monomethylation GO:0018026 ISS peptidyl-lysine dimethylation GO:0018027 IDA 20118233 negative regulation of transcription, DNA-templated GO:0045892 ISS histone H3-K9 methylation GO:0051567 IEA response to fungicide GO:0060992 IEA histone H3-K27 methylation GO:0070734 IEA regulation of signal transduction by p53 class mediator GO:1901796 TAS",20118233 IPI GO:0002039 p53 binding 19061646 20871592 21131967 26496610 IPI GO:0005515 protein binding 12004135 IDA GO:0008168 methyltransferase activity IEA GO:0008270 zinc ion binding 20118233 IDA GO:0016279 protein-lysine N-methyltransferase activity 12004135 IDA GO:0018024 histone-lysine N-methyltransferase activity ISS GO:0046974 histone methyltransferase activity (H3-K9 specific) ISS GO:0046976 histone methyltransferase activity (H3-K27 specific) IEA GO:0070742 C2H2 zinc finger domain binding,Lysine degradation - Homo sapiens (human) hsa00310,chemicalprobes.org UNC0638,Q9H9B1,"Histone-lysine N-methyltransferase, H3 lysine-9 specific 5",0.0,NA,NA,NA,NA,NA,NA,NA,NULL,79813,EHMT1,R-HSA-2262752 Cellular responses to stress R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559583 Cellular Senescence R-HSA-3214841 PKMTs methylate histone lysines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization,nucleus IC 12004135 GO:0005634 nucleus IDA 19144645 GO:0005634 nucleus ISS GO:0005634 nucleoplasm IDA GO:0005654 nucleoplasm TAS GO:0005654 chromosome IEA GO:0005694,"negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA DNA methylation GO:0006306 ISS embryo development GO:0009790 ISS chromatin modification GO:0016568 IDA 12004135 histone methylation GO:0016571 IDA 12004135 peptidyl-lysine monomethylation GO:0018026 ISS peptidyl-lysine dimethylation GO:0018027 IDA 20118233 negative regulation of transcription, DNA-templated GO:0045892 ISS histone H3-K9 methylation GO:0051567 IEA response to fungicide GO:0060992 IEA histone H3-K27 methylation GO:0070734 IEA regulation of signal transduction by p53 class mediator GO:1901796 TAS",20118233 IPI GO:0002039 p53 binding 19061646 20871592 21131967 26496610 IPI GO:0005515 protein binding 12004135 IDA GO:0008168 methyltransferase activity IEA GO:0008270 zinc ion binding 20118233 IDA GO:0016279 protein-lysine N-methyltransferase activity 12004135 IDA GO:0018024 histone-lysine N-methyltransferase activity ISS GO:0046974 histone methyltransferase activity (H3-K9 specific) ISS GO:0046976 histone methyltransferase activity (H3-K27 specific) IEA GO:0070742 C2H2 zinc finger domain binding,Lysine degradation - Homo sapiens (human) hsa00310,chemicalprobes.org UNC0642,Q9H9B1,"Histone-lysine N-methyltransferase, H3 lysine-9 specific 5",0.0,NA,NA,NA,NA,NA,NA,NA,NULL,79813,EHMT1,R-HSA-2262752 Cellular responses to stress R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559583 Cellular Senescence R-HSA-3214841 PKMTs methylate histone lysines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization,nucleus IC 12004135 GO:0005634 nucleus IDA 19144645 GO:0005634 nucleus ISS GO:0005634 nucleoplasm IDA GO:0005654 nucleoplasm TAS GO:0005654 chromosome IEA GO:0005694,"negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA DNA methylation GO:0006306 ISS embryo development GO:0009790 ISS chromatin modification GO:0016568 IDA 12004135 histone methylation GO:0016571 IDA 12004135 peptidyl-lysine monomethylation GO:0018026 ISS peptidyl-lysine dimethylation GO:0018027 IDA 20118233 negative regulation of transcription, DNA-templated GO:0045892 ISS histone H3-K9 methylation GO:0051567 IEA response to fungicide GO:0060992 IEA histone H3-K27 methylation GO:0070734 IEA regulation of signal transduction by p53 class mediator GO:1901796 TAS",20118233 IPI GO:0002039 p53 binding 19061646 20871592 21131967 26496610 IPI GO:0005515 protein binding 12004135 IDA GO:0008168 methyltransferase activity IEA GO:0008270 zinc ion binding 20118233 IDA GO:0016279 protein-lysine N-methyltransferase activity 12004135 IDA GO:0018024 histone-lysine N-methyltransferase activity ISS GO:0046974 histone methyltransferase activity (H3-K9 specific) ISS GO:0046976 histone methyltransferase activity (H3-K27 specific) IEA GO:0070742 C2H2 zinc finger domain binding,Lysine degradation - Homo sapiens (human) hsa00310,chemicalprobes.org MIV-6R,Q03164,Histone-lysine N-methyltransferase MLL,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,4297,KMT2A,R-HSA-3214841 PKMTs methylate histone lysines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization,nucleus IDA 11313484 15640349 22046413 GO:0005634 nucleus NAS 1423624 GO:0005634 nucleoplasm IDA GO:0005654 nucleoplasm TAS GO:0005654 cytoplasm IDA GO:0005737 histone methyltransferase complex IDA 19556245 GO:0035097 MLL1 complex IDA 15960975 GO:0071339,"DNA methylation GO:0006306 IEA transcription from RNA polymerase II promoter GO:0006366 10821850 TAS protein complex assembly GO:0006461 15199122 IDA apoptotic process GO:0006915 IEA negative regulation of cell proliferation GO:0008285 IEA visual learning GO:0008542 IEA post-embryonic development GO:0009791 IEA anterior/posterior pattern specification GO:0009952 IEA peptidyl-lysine monomethylation GO:0018026 IEA positive regulation of transporter activity GO:0032411 20861184 IMP circadian regulation of gene expression GO:0032922 ISS embryonic hemopoiesis GO:0035162 15618964 TAS exploration behavior GO:0035640 IEA response to potassium ion GO:0035864 IEA histone H4-K16 acetylation GO:0043984 15960975 IMP histone H3-K4 dimethylation GO:0044648 IEA positive regulation of transcription, DNA-templated GO:0045893 15960975 IMP positive regulation of transcription from RNA polymerase II promoter GO:0045944 20861184 IDA regulation of short-term neuronal synaptic plasticity GO:0048172 IEA spleen development GO:0048536 IEA homeostasis of number of cells within a tissue GO:0048873 IEA histone H3-K4 methylation GO:0051568 19556245 IDA histone H3-K4 methylation GO:0051568 15960975 IMP positive regulation of histone H3-K4 methylation GO:0051571 ISS membrane depolarization GO:0051899 IEA definitive hemopoiesis GO:0060216 IEA regulation of histone H3-K14 acetylation GO:0071440 ISS histone H3-K4 trimethylation GO:0080182 20861184 IDA regulation of histone H3-K27 acetylation GO:1901674 IEA regulation of histone H3-K9 acetylation GO:2000615 ISS positive regulation of cellular response to drug GO:2001040 20861184 IMP","core promoter sequence-specific DNA binding GO:0001046 ISS AT DNA binding GO:0003680 1423624 NAS chromatin binding GO:0003682 IEA transcription factor activity, sequence-specific DNA binding GO:0003700 10821850 NAS protein binding GO:0005515 11313484 15199122 15960975 18840606 19187761 19556245 20541251 20541477 20581860 20969867 23870121 IPI zinc ion binding GO:0008270 16990798 19187761 IDA histone-lysine N-methyltransferase activity GO:0018024 TAS histone methyltransferase activity (H3-K4 specific) GO:0042800 19187761 19556245 IDA histone methyltransferase activity (H3-K4 specific) GO:0042800 15960975 IMP identical protein binding GO:0042802 10656681 11313484 IPI protein homodimerization activity GO:0042803 11313484 IDA transcription regulatory region DNA binding GO:0044212 20484083 IDA unmethylated CpG binding GO:0045322 16990798 IDA lysine-acetylated histone binding GO:0070577 19187761 IDA",Lysine degradation - Homo sapiens (human) hsa00310 Transcriptional misregulation in cancer - Homo sapiens (human) hsa05202,chemicalprobes.org (R)-PFI-2,Q8WTS6,Histone-lysine N-methyltransferase SETD7,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,80854,SETD7,PKMTs methylate histone lysines R-HSA-3214841 Chromatin modifying enzymes R-HSA-3247509 Chromatin organization R-HSA-4839726,TAS GO:0005654 nucleoplasm IEA GO:0005694 chromosome IDA GO:0005730 nucleolus,"transcription, DNA-templated GO:0006351 IEA cellular response to DNA damage stimulus GO:0006974 23509280 IDA chromatin modification GO:0016568 12514135 NAS peptidyl-lysine monomethylation GO:0018026 17108971 IDA peptidyl-lysine dimethylation GO:0018027 17108971 IDA histone lysine methylation GO:0034968 IEA response to ethanol GO:0045471 IEA positive regulation of transcription, DNA-templated GO:0045893 IEA regulation of histone H3-K9 methylation GO:0051570 IEA heterochromatin organization GO:0070828 23509280 IDA",17108971 GO:0002039 p53 binding IPI GO:0003682 chromatin binding IEA 12540855 15525938 16415881 19262565 21119616 21131967 21988832 22345554 22402663 GO:0005515 protein binding IPI 16415881 17108971 GO:0016279 protein-lysine N-methyltransferase activity IDA 16415881 17707234 GO:0018024 histone-lysine N-methyltransferase activity IDA 12514135 GO:0018024 histone-lysine N-methyltransferase activity NAS GO:0018024 histone-lysine N-methyltransferase activity TAS,Lysine degradation - Homo sapiens (human) hsa00310 FoxO signaling pathway - Homo sapiens (human) hsa04068,chemicalprobes.org NVP-AEW541,P08069,Insulin-like growth factor I receptor,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,3480,IGF1R,Signal Transduction R-HSA-162582 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 SHC-related events triggered by IGF1R R-HSA-2428933,GO:0005886 plasma membrane ISS GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 7679099 IC GO:0016020 membrane 8452530 IDA GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex 19578119 IDA GO:0043231 intracellular membrane-bounded organelle 8452530 IDA GO:0043235 receptor complex 23382219 IDA,IMP 16886151 immune response GO:0006955 TAS 3003744 signal transduction GO:0007165 TAS 10749889 positive regulation of cell proliferation GO:0008284 TAS 10829031 insulin receptor signaling pathway GO:0008286 IC 7541045 phosphatidylinositol 3-kinase signaling GO:0014065 IMP 12138094 positive regulation of cell migration GO:0030335 IMP 19545541 peptidyl-tyrosine autophosphorylation GO:0038083 IDA 12556535 negative regulation of apoptotic process GO:0043066 IMP 12138094 positive regulation of DNA replication GO:0045740 IDA 12556535 regulation of JNK cascade GO:0046328 IDA 1846292 7679099 11162456 protein autophosphorylation GO:0046777 IDA 7679099 insulin-like growth factor receptor signaling pathway GO:0048009 IDA 7692086 phosphatidylinositol-mediated signaling GO:0048015 IDA 1846292 protein tetramerization GO:0051262 IDA 12556535 inactivation of MAPKK activity GO:0051389,protein tyrosine kinase activity GO:0004713 7679099 11162456 IDA protein tyrosine kinase activity GO:0004713 11884589 IMP protein tyrosine kinase activity GO:0004713 TAS insulin-like growth factor-activated receptor activity GO:0005010 7679099 IDA insulin receptor binding GO:0005158 8452530 IDA protein binding GO:0005515 7541045 7589433 7642582 8452530 8603569 8895367 8999839 9480911 9727029 10026153 11724822 12482592 12556535 15878855 15976035 15998644 16926280 20195357 21685939 22245152 22261717 25241761 25416956 IPI insulin-like growth factor binding GO:0005520 1846292 7679099 IDA ATP binding GO:0005524 IEA insulin-like growth factor I binding GO:0031994 19578119 IDA insulin-like growth factor I binding GO:0031994 8452530 IPI identical protein binding GO:0042802 11448933 17586502 IPI phosphatidylinositol 3-kinase binding GO:0043548 7541045 IPI insulin binding GO:0043559 8452530 IPI insulin receptor substrate binding GO:0043560 7541045 IPI,Ras signaling pathway - Homo sapiens (human) hsa04014 Rap1 signaling pathway - Homo sapiens (human) hsa04015 HIF-1 signaling pathway - Homo sapiens (human) hsa04066 FoxO signaling pathway - Homo sapiens (human) hsa04068 Oocyte meiosis - Homo sapiens (human) hsa04114 Endocytosis - Homo sapiens (human) hsa04144 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 AMPK signaling pathway - Homo sapiens (human) hsa04152 Focal adhesion - Homo sapiens (human) hsa04510 Adherens junction - Homo sapiens (human) hsa04520 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04550 Long-term depression - Homo sapiens (human) hsa04730 Ovarian steroidogenesis - Homo sapiens (human) hsa04913 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04914 Pathways in cancer - Homo sapiens (human) hsa05200 Transcriptional misregulation in cancer - Homo sapiens (human) hsa05202 Proteoglycans in cancer - Homo sapiens (human) hsa05205 Glioma - Homo sapiens (human) hsa05214 Prostate cancer - Homo sapiens (human) hsa05215 Melanoma - Homo sapiens (human) hsa05218,chemicalprobes.org GSK864,O75874,Isocitrate dehydrogenase [NADP] cytoplasmic,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,3417,IDHC,Metabolism R-HSA-1430728 Disease R-HSA-1643685 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate R-HSA-2978092 NADPH regeneration R-HSA-389542 Peroxisomal lipid metabolism R-HSA-390918 Metabolism of lipids and lipoproteins R-HSA-556833 Diseases of metabolism R-HSA-5668914,cytoplasm GO:0005737 IDA mitochondrion GO:0005739 IEA peroxisome 10521434 GO:0005777 IDA peroxisomal matrix GO:0005782 TAS cytosol 10521434 GO:0005829 IDA cytosol GO:0005829 TAS extracellular exosome 19056867 23376485 23533145 GO:0070062 IDA,glyoxylate cycle GO:0006097 IEA tricarboxylic acid cycle GO:0006099 IEA isocitrate metabolic process GO:0006102 IDA 10521434 19935646 20171178 2-oxoglutarate metabolic process GO:0006103 IDA 19935646 2-oxoglutarate metabolic process GO:0006103 TAS NADPH regeneration GO:0006740 TAS glutathione metabolic process GO:0006749 IEA response to oxidative stress GO:0006979 IEA female gonad development GO:0008585 IEA response to steroid hormone GO:0048545 IEA regulation of phospholipid catabolic process GO:0060696 IEA regulation of phospholipid biosynthetic process GO:0071071 IEA,magnesium ion binding GO:0000287 IDA 19935646 isocitrate dehydrogenase (NADP+) activity GO:0004450 EXP 15173171 19935646 isocitrate dehydrogenase (NADP+) activity GO:0004450 IDA 10521434 19935646 20171178 receptor binding GO:0005102 IPI 20178365 protein homodimerization activity GO:0042803 IPI 19935646 NADP binding GO:0050661 IEA NAD binding GO:0051287 IEA (R)-2-hydroxyglutarate dehydrogenase activity GO:0051990 EXP 19935646,hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human) hsa00480 Glutathione metabolism - Homo sapiens (human) hsa04146 Peroxisome - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human),chemicalprobes.org AGI-5198,O75874,Isocitrate dehydrogenase [NADP] cytoplasmic,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,3417,IDHC,Metabolism R-HSA-1430728 Disease R-HSA-1643685 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate R-HSA-2978092 NADPH regeneration R-HSA-389542 Peroxisomal lipid metabolism R-HSA-390918 Metabolism of lipids and lipoproteins R-HSA-556833 Diseases of metabolism R-HSA-5668914,cytoplasm GO:0005737 IDA mitochondrion GO:0005739 IEA peroxisome 10521434 GO:0005777 IDA peroxisomal matrix GO:0005782 TAS cytosol 10521434 GO:0005829 IDA cytosol GO:0005829 TAS extracellular exosome 19056867 23376485 23533145 GO:0070062 IDA,glyoxylate cycle GO:0006097 IEA tricarboxylic acid cycle GO:0006099 IEA isocitrate metabolic process GO:0006102 IDA 10521434 19935646 20171178 2-oxoglutarate metabolic process GO:0006103 IDA 19935646 2-oxoglutarate metabolic process GO:0006103 TAS NADPH regeneration GO:0006740 TAS glutathione metabolic process GO:0006749 IEA response to oxidative stress GO:0006979 IEA female gonad development GO:0008585 IEA response to steroid hormone GO:0048545 IEA regulation of phospholipid catabolic process GO:0060696 IEA regulation of phospholipid biosynthetic process GO:0071071 IEA,magnesium ion binding GO:0000287 IDA 19935646 isocitrate dehydrogenase (NADP+) activity GO:0004450 EXP 15173171 19935646 isocitrate dehydrogenase (NADP+) activity GO:0004450 IDA 10521434 19935646 20171178 receptor binding GO:0005102 IPI 20178365 protein homodimerization activity GO:0042803 IPI 19935646 NADP binding GO:0050661 IEA NAD binding GO:0051287 IEA (R)-2-hydroxyglutarate dehydrogenase activity GO:0051990 EXP 19935646,hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human) hsa00480 Glutathione metabolism - Homo sapiens (human) hsa04146 Peroxisome - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human),chemicalprobes.org Salvinorin A,P41145,Kappa opioid receptor,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,4986,OPRK,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,TAS GO:0005886 plasma membrane 7624359 IMP GO:0005887 integral component of plasma membrane 22437504 IDA GO:0016021 integral component of membrane IEA GO:0030425 dendrite IBA GO:0043005 neuron projection IEA GO:0043204 perikaryon IEA GO:0043679 axon terminus IEA GO:0045202 synapse,8755601 GO:0006955 immune response IDA 7624359 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS GO:0007218 neuropeptide signaling pathway IBA 7624359 GO:0007268 chemical synaptic transmission TAS 7624359 GO:0007600 sensory perception TAS 7624359 GO:0007610 behavior TAS GO:0007626 locomotory behavior ISS GO:0009314 response to radiation IEA GO:0019233 sensory perception of pain IBA GO:0019233 sensory perception of pain ISS 22437504 GO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway IDA GO:0032868 response to insulin IEA GO:0033603 positive regulation of dopamine secretion IEA GO:0033685 negative regulation of luteinizing hormone secretion IEA 8755601 GO:0038003 opioid receptor signaling pathway IDA GO:0040017 positive regulation of locomotion IEA GO:0042711 maternal behavior IEA GO:0042755 eating behavior IEA GO:0043278 response to morphine IEA GO:0043627 response to estrogen IEA GO:0044849 estrous cycle IEA GO:0045471 response to ethanol IEA GO:0046877 regulation of saliva secretion ISS GO:0048148 behavioral response to cocaine IEA GO:0050951 sensory perception of temperature stimulus IEA 8755601 GO:0051607 defense response to virus IDA GO:0051930 regulation of sensory perception of pain IEA GO:0071222 cellular response to lipopolysaccharide IEA GO:1900745 positive regulation of p38MAPK cascade IEA GO:1901381 positive regulation of potassium ion transmembrane transport IEA GO:1903715 regulation of aerobic respiration IEA GO:1903937 response to acrylamide IEA GO:1990708 conditioned place preference IEA GO:2000505 regulation of energy homeostasis IEA,22437504 GO:0004985 opioid receptor activity IDA 16431922 GO:0005515 protein binding IPI 8755601 GO:0038048 dynorphin receptor activity IDA 7624359 GO:0038048 dynorphin receptor activity IMP GO:0042923 neuropeptide binding IBA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),chemicalprobes.org UNC1215,Q96JM7,Lethal(3)malignant brain tumor-like protein 3,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,84456,LMBL3,,nucleus GO:0005634 IEA,"GO:0006351 transcription, DNA-templated IEA GO:0006355 regulation of transcription, DNA-templated IEA GO:0016568 chromatin modification IEA GO:0030225 macrophage differentiation IEA GO:0030851 granulocyte differentiation IEA GO:0043249 erythrocyte maturation IEA",GO:0003674 molecular_function ND GO:0005515 protein binding 21516116 25416956 IPI,,chemicalprobes.org GNE7915,Q5S007,Leucine-rich repeat serine/threonine-protein kinase 2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,120892,LRRK2,,"extracellular space GO:0005615 IDA 22664934 intracellular GO:0005622 IMP 22012985 cytoplasm GO:0005737 IDA 16321986 16352719 19625296 mitochondrion GO:0005739 IDA 21850687 mitochondrial outer membrane GO:0005741 ISS mitochondrial inner membrane GO:0005743 ISS mitochondrial matrix GO:0005759 ISS lysosome GO:0005764 ISS endosome GO:0005768 ISS endoplasmic reticulum GO:0005783 IDA 19640926 endoplasmic reticulum GO:0005783 ISS Golgi apparatus GO:0005794 ISS Golgi-associated vesicle GO:0005798 IDA 24510904 trans-Golgi network GO:0005802 IEA cytosol GO:0005829 IDA 21850687 22736029 22899650 24403142 cytosol GO:0005829 TAS plasma membrane GO:0005886 IDA 22899650 caveola GO:0005901 IDA 19640926 microvillus GO:0005902 IDA 19640926 inclusion body GO:0016234 IMP 24403142 cell junction GO:0030054 IEA axon GO:0030424 IDA 17120249 axon GO:0030424 ISS dendrite GO:0030425 IDA 17120249 dendrite GO:0030425 ISS growth cone GO:0030426 IDA 19625296 intracellular ribonucleoprotein complex GO:0030529 IEA synaptic vesicle membrane GO:0030672 IEA cytoplasmic vesicle GO:0031410 ISS mitochondrial membrane GO:0031966 IDA 22736029 cytoplasmic side of mitochondrial outer membrane GO:0032473 IDA 16269541 dendrite cytoplasm GO:0032839 IDA 21696411 neuron projection GO:0043005 IDA 19625296 21048939 neuronal cell body GO:0043025 IDA 21048939 21696411 terminal bouton GO:0043195 TAS 21563316 perikaryon GO:0043204 IDA 17120249 perikaryon GO:0043204 ISS amphisome GO:0044753 IDA 19640926 autolysosome GO:0044754 IDA 19640926 extracellular exosome GO:0070062 IDA 19056867 multivesicular body, internal vesicle GO:0097487 IDA 19640926 postsynapse GO:0098794 IEA Wnt signalosome GO:1990909 IDA 22899650 Wnt signalosome GO:1990909 NAS 24115276","17200152 IDA GO:0000165 MAPK cascade 19302196 IDA GO:0000186 activation of MAPKK activity 21857923 IMP GO:0000187 activation of MAPK activity ISS GO:0001933 negative regulation of protein phosphorylation 22012985 IDA GO:0001934 positive regulation of protein phosphorylation 20659558 IMP GO:0001934 positive regulation of protein phosphorylation 25500533 IDA GO:0006468 protein phosphorylation 23628791 IMP GO:0006468 protein phosphorylation 24576675 IGI GO:0006897 endocytosis 24576675 IMP GO:0006897 endocytosis IEA GO:0006914 autophagy 19692353 IMP GO:0006979 response to oxidative stress 22764206 IMP GO:0007005 mitochondrion organization 24510904 IMP GO:0007030 Golgi organization 25416817 IMP GO:0007040 lysosome organization IEA GO:0007264 small GTPase mediated signal transduction 21159966 IMP GO:0007528 neuromuscular junction development 19692353 IMP GO:0008340 determination of adult lifespan 24211199 IMP GO:0009267 cellular response to starvation 24211199 IMP GO:0010506 regulation of autophagy 22012985 IMP GO:0010508 positive regulation of autophagy ISS GO:0010508 positive regulation of autophagy ISS GO:0010738 regulation of protein kinase A signaling 21370995 IDA GO:0010955 negative regulation of protein processing 21168496 IMP GO:0014041 regulation of neuron maturation 19640926 IMP GO:0016242 negative regulation of macroautophagy 23916833 IMP GO:0016310 phosphorylation 19576176 IDA GO:0018105 peptidyl-serine phosphorylation 21048939 IDA GO:0018107 peptidyl-threonine phosphorylation 23949442 IMP GO:0018107 peptidyl-threonine phosphorylation 25416817 IMP GO:0019722 calcium-mediated signaling 21168496 IMP GO:0021772 olfactory bulb development 21168496 IMP GO:0022028 tangential migration from the subventricular zone to the olfactory bulb 16352719 20173330 IDA GO:0031398 positive regulation of protein ubiquitination 23949442 IMP GO:0032091 negative regulation of protein binding 21370995 IDA GO:0032092 positive regulation of protein binding ISS GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 22423108 IDA GO:0034260 negative regulation of GTPase activity 21362567 21857923 22764206 IMP GO:0034599 cellular response to oxidative stress ISS GO:0034613 cellular protein localization ISS GO:0035556 intracellular signal transduction ISS GO:0035564 regulation of kidney size 20659558 IMP GO:0035640 exploration behavior IEA GO:0035641 locomotory exploration behavior 22012985 IMP GO:0035751 regulation of lysosomal lumen pH 19692353 IMP GO:0040012 regulation of locomotion 21159966 IMP GO:0042391 regulation of membrane potential 17200152 IDA GO:0043068 positive regulation of programmed cell death 23628791 IC GO:0043406 positive regulation of MAP kinase activity IEA GO:0043547 positive regulation of GTPase activity 21048939 IDA GO:0046039 GTP metabolic process 16269541 16321986 17200152 17442267 IDA GO:0046777 protein autophosphorylation 16980962 IMP GO:0046777 protein autophosphorylation 21159966 IMP GO:0048312 intracellular distribution of mitochondria 17114044 IMP GO:0048812 neuron projection morphogenesis 22012985 IMP GO:0050848 regulation of calcium-mediated signaling 22764206 IMP GO:0051646 mitochondrion localization 22736029 IMP GO:0051900 regulation of mitochondrial depolarization ISS GO:0051966 regulation of synaptic transmission, glutamatergic 24115276 TAS GO:0060070 canonical Wnt signaling pathway ISS GO:0060079 excitatory postsynaptic potential ISS GO:0060159 regulation of dopamine receptor signaling pathway 20659558 IMP GO:0060161 positive regulation of dopamine receptor signaling pathway 22988876 TAS GO:0060828 regulation of canonical Wnt signaling pathway 21168496 IMP GO:0061001 regulation of dendritic spine morphogenesis ISS GO:0061001 regulation of dendritic spine morphogenesis 24252804 TAS GO:0070585 protein localization to mitochondrion 19692353 IMP GO:0070997 neuron death 23628791 IMP GO:0071287 cellular response to manganese ion 24576675 IMP GO:0072593 reactive oxygen species metabolic process 24252804 TAS GO:0090140 regulation of mitochondrial fission 22899650 IGI GO:0090263 positive regulation of canonical Wnt signaling pathway ISS GO:0090394 negative regulation of excitatory postsynaptic potential 24403142 IMP GO:1901214 regulation of neuron death 21857923 IGI GO:1901215 negative regulation of neuron death 21857923 IMP GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 16352719 IDA GO:1902499 positive regulation of protein autoubiquitination 21168496 IMP GO:1902692 regulation of neuroblast proliferation ISS GO:1902803 regulation of synaptic vesicle transport 21563316 TAS GO:1902803 regulation of synaptic vesicle transport 23949442 TAS GO:1902823 negative regulation of late endosome to lysosome transport 23916833 IMP GO:1902902 negative regulation of autophagosome assembly 21850687 IDA GO:1903125 negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation 24576675 IMP GO:1903206 negative regulation of hydrogen peroxide-induced cell death 21370995 IDA GO:1903215 negative regulation of protein targeting to mitochondrion 21370995 IC GO:1903217 negative regulation of protein processing involved in protein targeting to mitochondrion 23628791 IMP GO:1903351 cellular response to dopamine 22899650 IPI GO:1904887 Wnt signalosome assembly 24115276 TAS GO:1904887 Wnt signalosome assembly 21168496 IMP GO:2000172 regulation of branching morphogenesis of a nerve 23949442 IMP GO:2000300 regulation of synaptic vesicle exocytosis",SNARE binding 21307259 GO:0000149 IPI glycoprotein binding 21307259 GO:0001948 IPI actin binding 21307259 GO:0003779 IPI GTPase activity 21048939 GO:0003924 IDA protein kinase activity 16269541 16321986 17442267 21850687 25500533 GO:0004672 IDA protein serine/threonine kinase activity 17200152 19576176 21048939 21850687 22423108 23949442 GO:0004674 IDA protein serine/threonine kinase activity 22899650 GO:0004674 TAS MAP kinase kinase activity 19302196 GO:0004708 IDA GTPase activator activity 17442267 GO:0005096 IDA protein binding 16321986 16352719 17400507 18445495 19176810 19625296 19712061 20067578 20144646 20173330 20642453 20671708 21048939 21159966 21307259 21370995 21454543 21658387 21850687 21983832 22228096 22303461 22363216 22612223 22639965 22899650 22952686 22998870 23075850 23183827 23241358 23395371 23455607 23813973 23937259 23949442 24113872 24165324 24275654 24282027 24351927 24459295 24464040 24510904 24687852 24695735 24725412 24754922 24794857 24904275 24947832 25009464 25201882 25360523 25446991 25500533 25501810 25605758 GO:0005515 IPI ATP binding GO:0005524 IEA GTP binding 16980962 17260967 17442267 GO:0005525 IDA GTP binding 22899650 GO:0005525 TAS microtubule binding 24115276 GO:0008017 TAS tubulin binding 21159966 GO:0015631 IDA kinase activity 17114044 GO:0016301 IDA kinase activity 23916833 GO:0016301 IMP Rho GTPase binding 21048939 GO:0017048 IPI syntaxin-1 binding 21307259 GO:0017075 IPI receptor signaling complex scaffold activity 22899650 GO:0030159 IC clathrin binding 21307259 GO:0030276 IPI GTP-dependent protein kinase activity 17260967 GO:0034211 IDA GTP-dependent protein kinase activity 17200152 GO:0034211 IMP peroxidase inhibitor activity 21850687 GO:0036479 IDA co-receptor binding 24115276 GO:0039706 TAS identical protein binding 16321986 18397888 19712061 19733152 20515039 21073465 22363216 22952686 23220480 23241358 24275654 24591621 24904275 GO:0042802 IPI protein homodimerization activity 16321986 GO:0042803 IPI ion channel binding 21370995 22012985 GO:0044325 IPI protein kinase A binding 24464040 GO:0051018 IPI beta-catenin destruction complex binding 24115276 GO:1904713 NAS,"Parkinson,s disease - Homo sapiens (human) hsa05012",chemicalprobes.org GSK-J4,O15550,Lysine-specific demethylase 6A,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,7403,KDM6A,R-HSA-3214842 HDMs demethylate histones R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization,IDA 17500065 nucleus GO:0005634 TAS GO:0005654 nucleoplasm IDA 17500065 histone methyltransferase complex GO:0035097 IDA 17500065 MLL3/4 complex GO:0044666,in utero embryonic development GO:0001701 IEA neural tube closure GO:0001843 IEA heart morphogenesis GO:0003007 IEA respiratory system process GO:0003016 IEA positive regulation of gene expression GO:0010628 IEA somite rostral/caudal axis specification GO:0032525 IEA multicellular organism growth GO:0035264 IEA mesodermal cell differentiation GO:0048333 IEA notochord morphogenesis GO:0048570 IEA histone H3-K4 methylation 17178841 GO:0051568 ISS oxidation-reduction process GO:0055114 IEA canonical Wnt signaling pathway GO:0060070 IEA histone H3-K27 demethylation GO:0071557 IEA,GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA GO:0031490 chromatin DNA binding IEA GO:0032452 histone demethylase activity TAS GO:0042802 identical protein binding IEA GO:0046872 metal ion binding IEA GO:0051213 dioxygenase activity IEA GO:0071558 histone demethylase activity (H3-K27 specific) IEA,hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human),chemicalprobes.org GSK-J4,O15054,Lysine-specific demethylase 6B,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,23135,KDM6B,Cellular responses to stress R-HSA-2262752 Oxidative Stress Induced Senescence R-HSA-2559580 Cellular Senescence R-HSA-2559583 HDMs demethylate histones R-HSA-3214842 Chromatin modifying enzymes R-HSA-3247509 Chromatin organization R-HSA-4839726,23856522 ISS GO:0005634 nucleus TAS GO:0005654 nucleoplasm,GO:0002437 inflammatory response to antigenic stimulus IEA GO:0014823 response to activity IEA GO:0021766 hippocampus development IEA GO:0045165 cell fate commitment IEA 23856522 GO:0045446 endothelial cell differentiation ISS 23856522 GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS 23856522 GO:0048333 mesodermal cell differentiation ISS 23856522 GO:0055007 cardiac muscle cell differentiation ISS GO:0055114 oxidation-reduction process IEA GO:0060992 response to fungicide IEA GO:0070301 cellular response to hydrogen peroxide IEA GO:0071557 histone H3-K27 demethylation IEA,chromatin binding IEA GO:0003682 protein binding IPI 21841772 GO:0005515 beta-catenin binding IEA GO:0008013 histone demethylase activity TAS GO:0032452 sequence-specific DNA binding IEA GO:0043565 metal ion binding IEA GO:0046872 dioxygenase activity IEA GO:0051213 histone demethylase activity (H3-K27 specific) EXP 17825402 GO:0071558,,chemicalprobes.org PF3644022,P49137,MAP kinase-activated protein kinase 2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,9261,MAPK2,Metabolism R-HSA-1430728 Signal Transduction R-HSA-162582 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 Activated TLR4 signalling R-HSA-166054 MyD88:Mal cascade initiated on plasma membrane R-HSA-166058 MyD88-independent TLR3/TLR4 cascade R-HSA-166166 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168180 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Toll-Like Receptors Cascades R-HSA-168898 p38MAPK events R-HSA-171007 Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signaling by VEGF R-HSA-194138 Nuclear Events (kinase and transcription factor activation) R-HSA-198725 CREB phosphorylation R-HSA-199920 Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 Arachidonic acid metabolism R-HSA-2142753 Cellular responses to stress R-HSA-2262752 Oxidative Stress Induced Senescence R-HSA-2559580 Cellular Senescence R-HSA-2559583 Regulation of HSF1-mediated heat shock response R-HSA-3371453 Cellular response to heat stress R-HSA-3371556 VEGFA-VEGFR2 Pathway R-HSA-4420097 MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 MAP kinase activation in TLR cascade R-HSA-450294 activated TAK1 mediates p38 MAPK activation R-HSA-450302 Butyrate Response Factor 1 (BRF1) destabilizes mRNA R-HSA-450385 Tristetraprolin (TTP) destabilizes mRNA R-HSA-450513 Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 Metabolism of lipids and lipoproteins R-HSA-556833 Gene Expression R-HSA-74160 TRIF-mediated TLR3/TLR4 signaling R-HSA-937061 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 MyD88 dependent cascade initiated on endosome R-HSA-975155 MyD88 cascade initiated on plasma membrane R-HSA-975871,nucleus 20932473 GO:0005634 IDA nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS cytoplasm 20932473 GO:0005737 IDA centrosome GO:0005813 IDA cytosol GO:0005829 TAS extracellular exosome 18570454 GO:0070062 IDA,GO:0000165 MAPK cascade 8179591 TAS GO:0000187 activation of MAPK activity TAS GO:0002224 toll-like receptor signaling pathway ISS GO:0006468 protein phosphorylation 8179591 TAS GO:0006691 leukotriene metabolic process TAS GO:0006950 response to stress 15014438 IDA GO:0006954 inflammatory response IBA GO:0006954 inflammatory response ISS GO:0006974 cellular response to DNA damage stimulus 20932473 IMP GO:0007265 Ras protein signal transduction TAS GO:0018105 peptidyl-serine phosphorylation 15850461 IDA GO:0031572 G2 DNA damage checkpoint 20932473 IMP GO:0032496 response to lipopolysaccharide ISS GO:0032675 regulation of interleukin-6 production ISS GO:0032680 regulation of tumor necrosis factor production 15014438 IDA GO:0034097 response to cytokine 8774846 IDA GO:0035924 cellular response to vascular endothelial growth factor stimulus 18440775 IMP GO:0038066 p38MAPK cascade IEA GO:0042535 positive regulation of tumor necrosis factor biosynthetic process IEA GO:0043488 regulation of mRNA stability TAS GO:0044351 macropinocytosis ISS GO:0046777 protein autophosphorylation IBA GO:0048010 vascular endothelial growth factor receptor signaling pathway 18440775 IMP GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS GO:0048839 inner ear development IEA GO:0070935 3'-UTR-mediated mRNA stabilization 14517288 15014438 20932473 IDA GO:1900034 regulation of cellular response to heat TAS,protein kinase activity GO:0004672 TAS 8179591 protein serine/threonine kinase activity GO:0004674 EXP 7799959 16278218 protein serine/threonine kinase activity GO:0004674 IDA 2402373 8774846 8846784 14517288 15014438 15850461 20932473 protein serine/threonine kinase activity GO:0004674 TAS calmodulin-dependent protein kinase activity GO:0004683 IBA signal transducer activity GO:0004871 TAS 8179591 protein binding GO:0005515 IPI 8774846 14517288 15014438 16278218 17255097 19369945 20932473 21575178 21988832 23455922 23602568 25241761 25852190 26496610 calmodulin binding GO:0005516 IBA ATP binding GO:0005524 IEA calcium-dependent protein serine/threonine kinase activity GO:0009931 IBA,hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04370 VEGF signaling pathway - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human),chemicalprobes.org SCH772984,P27361,MAP kinase ERK1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,5595,MK03,"Hemostasis R-HSA-109582 MAPK3 (ERK1) activation R-HSA-110056 IRS-mediated signalling R-HSA-112399 RAF-independent MAPK1/3 activation R-HSA-112409 SOS-mediated signalling R-HSA-112412 ISG15 antiviral mechanism R-HSA-1169408 Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 SHC1 events in ERBB2 signaling R-HSA-1250196 SHC1 events in ERBB4 signaling R-HSA-1250347 Developmental Biology R-HSA-1266738 Cytokine Signaling in Immune system R-HSA-1280215 Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 Cell Cycle R-HSA-1640170 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 Activated TLR4 signalling R-HSA-166054 MyD88:Mal cascade initiated on plasma membrane R-HSA-166058 MyD88-independent TLR3/TLR4 cascade R-HSA-166166 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168180 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Toll-Like Receptors Cascades R-HSA-168898 Prolonged ERK activation events R-HSA-169893 Frs2-mediated activation R-HSA-170968 ARMS-mediated activation R-HSA-170984 Signaling by EGFR R-HSA-177929 GRB2 events in EGFR signaling R-HSA-179812 SHC1 events in EGFR signaling R-HSA-180336 Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signalling to p38 via RIT and RIN R-HSA-187706 Signaling by FGFR R-HSA-190236 Signaling by VEGF R-HSA-194138 Signaling by Rho GTPases R-HSA-194315 RHO GTPase Effectors R-HSA-195258 GRB2 events in ERBB2 signaling R-HSA-1963640 Nuclear Events (kinase and transcription factor activation) R-HSA-198725 ERK/MAPK targets R-HSA-198753 ERKs are inactivated R-HSA-202670 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 DAP12 interactions R-HSA-2172127 Cellular responses to stress R-HSA-2262752 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Oxidative Stress Induced Senescence R-HSA-2559580 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 Cellular Senescence R-HSA-2559583 Oncogene Induced Senescence R-HSA-2559585 Signaling by Leptin R-HSA-2586552 FCERI mediated MAPK activation R-HSA-2871796 Regulation of HSF1-mediated heat shock response R-HSA-3371453 Cellular response to heat stress R-HSA-3371556 Signaling by GPCR R-HSA-372790 L1CAM interactions R-HSA-373760 NCAM signaling for neurite out-growth R-HSA-375165 Axon guidance R-HSA-422475 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signal transduction by L1 R-HSA-445144 Signaling by Interleukins R-HSA-449147 MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 MAP kinase activation in TLR cascade R-HSA-450294 Activation of the AP-1 family of transcription factors R-HSA-450341 Interleukin-2 signaling R-HSA-451927 Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-504046 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 VEGFR2 mediated cell proliferation R-HSA-5218921 Downstream signaling of activated FGFR1 R-HSA-5654687 FRS-mediated FGFR1 signaling R-HSA-5654693 Downstream signaling of activated FGFR2 R-HSA-5654696 FRS-mediated FGFR2 signaling R-HSA-5654700 FRS-mediated FGFR3 signaling R-HSA-5654706 Downstream signaling of activated FGFR3 R-HSA-5654708 FRS-mediated FGFR4 signaling R-HSA-5654712 Downstream signaling of activated FGFR4 R-HSA-5654716 Negative regulation of FGFR1 signaling R-HSA-5654726 Negative regulation of FGFR2 signaling R-HSA-5654727 Negative regulation of FGFR3 signaling R-HSA-5654732 Negative regulation of FGFR4 signaling R-HSA-5654733 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 RHO GTPases Activate WASPs and WAVEs R-HSA-5663213 RAF/MAP kinase cascade R-HSA-5673001 MAP2K and MAPK activation R-HSA-5674135 Negative feedback regulation of MAPK pathway R-HSA-5674499 Negative regulation of MAPK pathway R-HSA-5675221 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 Mitotic Prophase R-HSA-68875 M Phase R-HSA-68886 Cell Cycle, Mitotic R-HSA-69278 RNA Polymerase I Promoter Opening R-HSA-73728 RNA Polymerase I Promoter Clearance R-HSA-73854 RNA Polymerase I Transcription R-HSA-73864 Transcription R-HSA-74159 Gene Expression R-HSA-74160 Signal attenuation R-HSA-74749 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Platelet activation, signaling and aggregation R-HSA-76002 Advanced glycosylation endproduct receptor signaling R-HSA-879415 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 Interleukin receptor SHC signaling R-HSA-912526 Interferon Signaling R-HSA-913531 TRIF-mediated TLR3/TLR4 signaling R-HSA-937061 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 MyD88 dependent cascade initiated on endosome R-HSA-975155 MyD88 cascade initiated on plasma membrane R-HSA-975871",19565474 TAS GO:0005634 nucleus 20455999 IDA GO:0005635 nuclear envelope IDA GO:0005654 nucleoplasm TAS GO:0005654 nucleoplasm 19565474 TAS GO:0005739 mitochondrion 19565474 TAS GO:0005769 early endosome 19565474 TAS GO:0005770 late endosome 19565474 TAS GO:0005794 Golgi apparatus 19565474 TAS GO:0005829 cytosol 19565474 TAS GO:0005856 cytoskeleton 19565474 TAS GO:0005901 caveola 19565474 TAS GO:0005925 focal adhesion IDA GO:0015630 microtubule cytoskeleton IEA GO:0031143 pseudopodium IEA GO:0043234 protein complex 23376485 IDA GO:0070062 extracellular exosome,MAPK cascade 20018936 GO:0000165 NAS MAPK cascade GO:0000165 TAS activation of MAPK activity GO:0000187 TAS MAPK import into nucleus GO:0000189 IEA positive regulation of protein phosphorylation 19664780 GO:0001934 IMP transcription initiation from RNA polymerase I promoter GO:0006361 TAS protein complex assembly GO:0006461 IEA protein phosphorylation 7687743 GO:0006468 IDA apoptotic process GO:0006915 IEA DNA damage induced protein phosphorylation 17560175 GO:0006975 IDA cell cycle GO:0007049 IEA axon guidance GO:0007411 TAS fibroblast growth factor receptor signaling pathway GO:0008543 TAS response to toxic substance GO:0009636 IEA regulation of phosphatidylinositol 3-kinase signaling GO:0014066 TAS viral process GO:0016032 IEA phosphorylation 15950189 GO:0016310 IDA peptidyl-serine phosphorylation GO:0018105 IEA sensory perception of pain GO:0019233 IEA arachidonic acid metabolic process GO:0019369 IEA platelet activation GO:0030168 TAS BMP signaling pathway 19664780 GO:0030509 IMP thyroid gland development GO:0030878 IEA positive regulation of cyclase activity 22027397 GO:0031281 IMP lipopolysaccharide-mediated signaling pathway GO:0031663 IEA positive regulation of telomere maintenance via telomerase 21531765 GO:0032212 IMP regulation of stress-activated MAPK cascade 19565474 GO:0032872 TAS positive regulation of histone phosphorylation 20018936 GO:0033129 IMP positive regulation of histone acetylation 20018936 GO:0035066 IMP peptidyl-tyrosine autophosphorylation 8388392 GO:0038083 IDA Fc-epsilon receptor signaling pathway GO:0038095 TAS Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS outer ear morphogenesis GO:0042473 IEA response to exogenous dsRNA GO:0043330 IEA positive regulation of translation GO:0045727 IEA positive regulation of transcription from RNA polymerase II promoter 20018936 GO:0045944 IMP thymus development GO:0048538 IEA regulation of sequence-specific DNA binding transcription factor activity GO:0051090 TAS cartilage development GO:0051216 IEA regulation of cytoskeleton organization 19565474 GO:0051493 TAS positive regulation of telomerase activity 21531765 GO:0051973 IMP Bergmann glial cell differentiation GO:0060020 IEA face development GO:0060324 IEA JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 TAS lung morphogenesis GO:0060425 IEA trachea formation GO:0060440 IEA cardiac neural crest cell development involved in heart development GO:0061308 IEA ERK1 and ERK2 cascade GO:0070371 IEA positive regulation of ERK1 and ERK2 cascade 19664780 GO:0070374 IMP interleukin-1-mediated signaling pathway 20018936 GO:0070498 IMP response to epidermal growth factor 18794356 21968647 GO:0070849 IDA cellular response to mechanical stimulus 19593445 GO:0071260 IEP caveolin-mediated endocytosis 19565474 GO:0072584 TAS regulation of Golgi inheritance 19565474 GO:0090170 TAS regulation of cellular response to heat GO:1900034 TAS positive regulation of telomere capping 21531765 GO:1904355 IMP positive regulation of xenophagy GO:1904417 IEA regulation of early endosome to late endosome transport 19565474 GO:2000641 TAS negative regulation of apolipoprotein binding GO:2000657 IEA,phosphotyrosine binding IEA GO:0001784 protein serine/threonine kinase activity TAS GO:0004674 MAP kinase activity IDA 8388392 GO:0004707 MAP kinase activity NAS 7687743 GO:0004707 MAP kinase activity TAS GO:0004707 protein binding IPI 10066421 10419510 10617468 11238443 12840032 15616583 15950189 16291755 18794356 19167335 19197339 19494114 19892016 20347885 20622900 23397142 23452857 23602568 24606918 24825908 25066297 25241761 25852190 26496610 GO:0005515 ATP binding IEA GO:0005524 kinase activity TAS GO:0016301 phosphatase binding IPI 19494114 GO:0019902 scaffold protein binding IEA GO:0097110,"MAPK signaling pathway - Homo sapiens (human) hsa04010 ErbB signaling pathway - Homo sapiens (human) hsa04012 Ras signaling pathway - Homo sapiens (human) hsa04014 Rap1 signaling pathway - Homo sapiens (human) hsa04015 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 cAMP signaling pathway - Homo sapiens (human) hsa04024 Chemokine signaling pathway - Homo sapiens (human) hsa04062 HIF-1 signaling pathway - Homo sapiens (human) hsa04066 FoxO signaling pathway - Homo sapiens (human) hsa04068 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 Oocyte meiosis - Homo sapiens (human) hsa04114 mTOR signaling pathway - Homo sapiens (human) hsa04150 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04261 Vascular smooth muscle contraction - Homo sapiens (human) hsa04270 Dorso-ventral axis formation - Homo sapiens (human) hsa04320 TGF-beta signaling pathway - Homo sapiens (human) hsa04350 Axon guidance - Homo sapiens (human) hsa04360 VEGF signaling pathway - Homo sapiens (human) hsa04370 Osteoclast differentiation - Homo sapiens (human) hsa04380 Focal adhesion - Homo sapiens (human) hsa04510 Adherens junction - Homo sapiens (human) hsa04520 Gap junction - Homo sapiens (human) hsa04540 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04550 Platelet activation - Homo sapiens (human) hsa04611 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04620 NOD-like receptor signaling pathway - Homo sapiens (human) hsa04621 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04650 T cell receptor signaling pathway - Homo sapiens (human) hsa04660 B cell receptor signaling pathway - Homo sapiens (human) hsa04662 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04664 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04666 TNF signaling pathway - Homo sapiens (human) hsa04668 Circadian entrainment - Homo sapiens (human) hsa04713 Long-term potentiation - Homo sapiens (human) hsa04720 Neurotrophin signaling pathway - Homo sapiens (human) hsa04722 Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04723 Glutamatergic synapse - Homo sapiens (human) hsa04724 Cholinergic synapse - Homo sapiens (human) hsa04725 Serotonergic synapse - Homo sapiens (human) hsa04726 Long-term depression - Homo sapiens (human) hsa04730 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04810 Insulin signaling pathway - Homo sapiens (human) hsa04910 GnRH signaling pathway - Homo sapiens (human) hsa04912 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04914 Estrogen signaling pathway - Homo sapiens (human) hsa04915 Melanogenesis - Homo sapiens (human) hsa04916 Prolactin signaling pathway - Homo sapiens (human) hsa04917 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04919 Oxytocin signaling pathway - Homo sapiens (human) hsa04921 Type II diabetes mellitus - Homo sapiens (human) hsa04930 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) hsa04960 Alzheimer,s disease - Homo sapiens (human) hsa05010 Prion diseases - Homo sapiens (human) hsa05020 Alcoholism - Homo sapiens (human) hsa05034 Shigellosis - Homo sapiens (human) hsa05131 Salmonella infection - Homo sapiens (human) hsa05132 Pertussis - Homo sapiens (human) hsa05133 Leishmaniasis - Homo sapiens (human) hsa05140 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05142 Toxoplasmosis - Homo sapiens (human) hsa05145 Tuberculosis - Homo sapiens (human) hsa05152 Hepatitis C - Homo sapiens (human) hsa05160 Hepatitis B - Homo sapiens (human) hsa05161 Influenza A - Homo sapiens (human) hsa05164 Pathways in cancer - Homo sapiens (human) hsa05200 Viral carcinogenesis - Homo sapiens (human) hsa05203 Proteoglycans in cancer - Homo sapiens (human) hsa05205 Colorectal cancer - Homo sapiens (human) hsa05210 Renal cell carcinoma - Homo sapiens (human) hsa05211 Pancreatic cancer - Homo sapiens (human) hsa05212 Endometrial cancer - Homo sapiens (human) hsa05213 Glioma - Homo sapiens (human) hsa05214 Prostate cancer - Homo sapiens (human) hsa05215 Thyroid cancer - Homo sapiens (human) hsa05216 Melanoma - Homo sapiens (human) hsa05218 Bladder cancer - Homo sapiens (human) hsa05219 Chronic myeloid leukemia - Homo sapiens (human) hsa05220 Acute myeloid leukemia - Homo sapiens (human) hsa05221 Non-small cell lung cancer - Homo sapiens (human) hsa05223 Central carbon metabolism in cancer - Homo sapiens (human) hsa05230 Choline metabolism in cancer - Homo sapiens (human) hsa05231",chemicalprobes.org SCH772984,P28482,MAP kinase ERK2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,5594,MK01,"R-HSA-109582 Hemostasis R-HSA-111885 Opioid Signalling R-HSA-111995 phospho-PLA2 pathway R-HSA-111996 Ca-dependent events R-HSA-112040 G-protein mediated events R-HSA-112043 PLC beta mediated events R-HSA-112314 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System R-HSA-112399 IRS-mediated signalling R-HSA-112409 RAF-independent MAPK1/3 activation R-HSA-112411 MAPK1 (ERK2) activation R-HSA-112412 SOS-mediated signalling R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250196 SHC1 events in ERBB2 signaling R-HSA-1250347 SHC1 events in ERBB4 signaling R-HSA-1266738 Developmental Biology R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1433557 Signaling by SCF-KIT R-HSA-162582 Signal Transduction R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-1640170 Cell Cycle R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166054 Activated TLR4 signalling R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-166166 MyD88-independent TLR3/TLR4 cascade R-HSA-166520 Signalling by NGF R-HSA-167044 Signalling to RAS R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168180 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-168898 Toll-Like Receptors Cascades R-HSA-169893 Prolonged ERK activation events R-HSA-170968 Frs2-mediated activation R-HSA-170984 ARMS-mediated activation R-HSA-177929 Signaling by EGFR R-HSA-179812 GRB2 events in EGFR signaling R-HSA-180336 SHC1 events in EGFR signaling R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-187687 Signalling to ERKs R-HSA-187706 Signalling to p38 via RIT and RIN R-HSA-190236 Signaling by FGFR R-HSA-194138 Signaling by VEGF R-HSA-194315 Signaling by Rho GTPases R-HSA-195258 RHO GTPase Effectors R-HSA-1963640 GRB2 events in ERBB2 signaling R-HSA-198725 Nuclear Events (kinase and transcription factor activation) R-HSA-198753 ERK/MAPK targets R-HSA-202670 ERKs are inactivated R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-2172127 DAP12 interactions R-HSA-2262752 Cellular responses to stress R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559583 Cellular Senescence R-HSA-2559585 Oncogene Induced Senescence R-HSA-2586552 Signaling by Leptin R-HSA-2871796 FCERI mediated MAPK activation R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-3371556 Cellular response to heat stress R-HSA-372790 Signaling by GPCR R-HSA-373760 L1CAM interactions R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-422475 Axon guidance R-HSA-437239 Recycling pathway of L1 R-HSA-438064 Post NMDA receptor activation events R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-442742 CREB phosphorylation through the activation of Ras R-HSA-442755 Activation of NMDA receptor upon glutamate binding and postsynaptic events R-HSA-444257 RSK activation R-HSA-445144 Signal transduction by L1 R-HSA-449147 Signaling by Interleukins R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450294 MAP kinase activation in TLR cascade R-HSA-450341 Activation of the AP-1 family of transcription factors R-HSA-451927 Interleukin-2 signaling R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654726 Negative regulation of FGFR1 signaling R-HSA-5654727 Negative regulation of FGFR2 signaling R-HSA-5654732 Negative regulation of FGFR3 signaling R-HSA-5654733 Negative regulation of FGFR4 signaling R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5674135 MAP2K and MAPK activation R-HSA-5674499 Negative feedback regulation of MAPK pathway R-HSA-5675221 Negative regulation of MAPK pathway R-HSA-5683057 MAPK family signaling cascades R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-68875 Mitotic Prophase R-HSA-68886 M Phase R-HSA-69278 Cell Cycle, Mitotic R-HSA-74749 Signal attenuation R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-879415 Advanced glycosylation endproduct receptor signaling R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-912526 Interleukin receptor SHC signaling R-HSA-937061 TRIF-mediated TLR3/TLR4 signaling R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-975871 MyD88 cascade initiated on plasma membrane",IDA 16791210 18794356 nucleus GO:0005634 TAS 19565474 nucleus GO:0005634 IDA GO:0005654 nucleoplasm TAS GO:0005654 nucleoplasm IDA 16791210 18794356 cytoplasm GO:0005737 ISS GO:0005737 cytoplasm TAS 19565474 mitochondrion GO:0005739 TAS 19565474 early endosome GO:0005769 TAS 19565474 late endosome GO:0005770 TAS 19565474 Golgi apparatus GO:0005794 IEA GO:0005815 microtubule organizing center TAS 19565474 cytosol GO:0005829 TAS 19565474 cytoskeleton GO:0005856 TAS 19565474 caveola GO:0005901 TAS 19565474 focal adhesion GO:0005925 IDA GO:0015630 microtubule cytoskeleton IEA GO:0030424 axon IEA GO:0031143 pseudopodium IEA GO:0032839 dendrite cytoplasm IEA GO:0043204 perikaryon IEA GO:0043234 protein complex IDA 23376485 extracellular exosome GO:0070062 ISS GO:0072686 mitotic spindle,"MAPK cascade GO:0000165 TAS activation of MAPK activity GO:0000187 TAS MAPK import into nucleus GO:0000189 IEA transcription, DNA-templated GO:0006351 IEA protein phosphorylation GO:0006468 23184662 IDA apoptotic process GO:0006915 IEA chemotaxis GO:0006935 10706854 TAS response to stress GO:0006950 10958679 TAS cellular response to DNA damage stimulus GO:0006974 IEA cell cycle GO:0007049 IEA signal transduction GO:0007165 1540184 TAS chemical synaptic transmission GO:0007268 10051431 TAS axon guidance GO:0007411 TAS positive regulation of cell proliferation GO:0008284 IEA fibroblast growth factor receptor signaling pathway GO:0008543 TAS response to toxic substance GO:0009636 IEA positive regulation of peptidyl-threonine phosphorylation GO:0010800 16314496 IDA regulation of phosphatidylinositol 3-kinase signaling GO:0014066 TAS viral process GO:0016032 IEA peptidyl-serine phosphorylation GO:0018105 15850461 IDA peptidyl-threonine phosphorylation GO:0018107 ISS sensory perception of pain GO:0019233 IEA cytosine metabolic process GO:0019858 IEA platelet activation GO:0030168 TAS positive regulation of cell migration GO:0030335 IEA thyroid gland development GO:0030878 IEA regulation of protein stability GO:0031647 ISS lipopolysaccharide-mediated signaling pathway GO:0031663 IEA positive regulation of telomere maintenance via telomerase GO:0032212 21531765 IMP regulation of stress-activated MAPK cascade GO:0032872 19565474 TAS mammary gland epithelial cell proliferation GO:0033598 IEA Fc-epsilon receptor signaling pathway GO:0038095 TAS Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS ERBB signaling pathway GO:0038127 15133037 IDA outer ear morphogenesis GO:0042473 IEA response to exogenous dsRNA GO:0043330 IEA response to estrogen GO:0043627 IEA negative regulation of cell differentiation GO:0045596 IEA positive regulation of translation GO:0045727 IEA positive regulation of transcription, DNA-templated GO:0045893 IEA thymus development GO:0048538 IEA T cell receptor signaling pathway GO:0050852 IEA B cell receptor signaling pathway GO:0050853 IEA regulation of sequence-specific DNA binding transcription factor activity GO:0051090 TAS regulation of cytoskeleton organization GO:0051493 19565474 TAS positive regulation of telomerase activity GO:0051973 21531765 IMP Bergmann glial cell differentiation GO:0060020 IEA long-term synaptic potentiation GO:0060291 IEA face development GO:0060324 IEA JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 TAS lung morphogenesis GO:0060425 IEA trachea formation GO:0060440 IEA labyrinthine layer blood vessel development GO:0060716 IEA cardiac neural crest cell development involved in heart development GO:0061308 IEA ERK1 and ERK2 cascade GO:0070371 16314496 IDA ERK1 and ERK2 cascade GO:0070371 TAS response to epidermal growth factor GO:0070849 18794356 IDA caveolin-mediated endocytosis GO:0072584 19565474 TAS regulation of Golgi inheritance GO:0090170 19565474 TAS cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 IEA regulation of cellular response to heat GO:1900034 TAS positive regulation of telomere capping GO:1904355 21531765 IMP regulation of early endosome to late endosome transport GO:2000641 19565474 TAS",GO:0001784 phosphotyrosine binding IEA GO:0003677 DNA binding IEA 15850461 18794356 GO:0004674 protein serine/threonine kinase activity IDA GO:0004674 protein serine/threonine kinase activity TAS GO:0004707 MAP kinase activity TAS 8626452 9632734 10415025 10601328 12592337 15133037 15713638 16286470 16288922 17255944 17255949 17620599 18616943 18794356 19494114 19892016 21988832 22253824 22521293 23241949 23397142 23560844 23602568 23847209 24735981 25241761 26267535 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0008134 transcription factor binding IEA GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity ISS GO:0016301 kinase activity TAS 19494114 GO:0019902 phosphatase binding IPI GO:0031435 mitogen-activated protein kinase kinase kinase binding IEA 26267534 GO:0042802 identical protein binding IPI,"hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04071 Sphingolipid signaling pathway - Homo sapiens (human) hsa04114 Oocyte meiosis - Homo sapiens (human) hsa04150 mTOR signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) hsa04320 Dorso-ventral axis formation - Homo sapiens (human) hsa04350 TGF-beta signaling pathway - Homo sapiens (human) hsa04360 Axon guidance - Homo sapiens (human) hsa04370 VEGF signaling pathway - Homo sapiens (human) hsa04380 Osteoclast differentiation - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04520 Adherens junction - Homo sapiens (human) hsa04540 Gap junction - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04611 Platelet activation - Homo sapiens (human) hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human) hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04660 T cell receptor signaling pathway - Homo sapiens (human) hsa04662 B cell receptor signaling pathway - Homo sapiens (human) hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04668 TNF signaling pathway - Homo sapiens (human) hsa04713 Circadian entrainment - Homo sapiens (human) hsa04720 Long-term potentiation - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04724 Glutamatergic synapse - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human) hsa04726 Serotonergic synapse - Homo sapiens (human) hsa04730 Long-term depression - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04910 Insulin signaling pathway - Homo sapiens (human) hsa04912 GnRH signaling pathway - Homo sapiens (human) hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04915 Estrogen signaling pathway - Homo sapiens (human) hsa04916 Melanogenesis - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04921 Oxytocin signaling pathway - Homo sapiens (human) hsa04930 Type II diabetes mellitus - Homo sapiens (human) hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) hsa05010 Alzheimer,s disease - Homo sapiens (human) hsa05020 Prion diseases - Homo sapiens (human) hsa05034 Alcoholism - Homo sapiens (human) hsa05131 Shigellosis - Homo sapiens (human) hsa05132 Salmonella infection - Homo sapiens (human) hsa05133 Pertussis - Homo sapiens (human) hsa05140 Leishmaniasis - Homo sapiens (human) hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05152 Tuberculosis - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human) hsa05161 Hepatitis B - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05210 Colorectal cancer - Homo sapiens (human) hsa05211 Renal cell carcinoma - Homo sapiens (human) hsa05212 Pancreatic cancer - Homo sapiens (human) hsa05213 Endometrial cancer - Homo sapiens (human) hsa05214 Glioma - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05216 Thyroid cancer - Homo sapiens (human) hsa05218 Melanoma - Homo sapiens (human) hsa05219 Bladder cancer - Homo sapiens (human) hsa05220 Chronic myeloid leukemia - Homo sapiens (human) hsa05221 Acute myeloid leukemia - Homo sapiens (human) hsa05223 Non-small cell lung cancer - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human) hsa05231 Choline metabolism in cancer - Homo sapiens (human)",chemicalprobes.org VX-745,Q16539,MAP kinase p38 alpha,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,1432,MK14,"R-HSA-109582 Hemostasis R-HSA-1266738 Developmental Biology R-HSA-1592230 Mitochondrial biogenesis R-HSA-162582 Signal Transduction R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166054 Activated TLR4 signalling R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-166166 MyD88-independent TLR3/TLR4 cascade R-HSA-166520 Signalling by NGF R-HSA-167044 Signalling to RAS R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168180 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-168638 NOD1/2 Signaling Pathway R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168898 Toll-Like Receptors Cascades R-HSA-171007 p38MAPK events R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-187687 Signalling to ERKs R-HSA-194138 Signaling by VEGF R-HSA-198725 Nuclear Events (kinase and transcription factor activation) R-HSA-198753 ERK/MAPK targets R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation R-HSA-2262752 Cellular responses to stress R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-2559583 Cellular Senescence R-HSA-375170 CDO in myogenesis R-HSA-392518 Signal amplification R-HSA-418346 Platelet homeostasis R-HSA-418592 ADP signalling through P2Y purinoceptor 1 R-HSA-432142 Platelet sensitization by LDL R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450294 MAP kinase activation in TLR cascade R-HSA-450302 activated TAK1 mediates p38 MAPK activation R-HSA-450341 Activation of the AP-1 family of transcription factors R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450604 KSRP destabilizes mRNA R-HSA-525793 Myogenesis R-HSA-74160 Gene Expression R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-937061 TRIF-mediated TLR3/TLR4 signaling R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-975871 MyD88 cascade initiated on plasma membrane",IEA GO:0000922 spindle pole ISS GO:0005634 nucleus IDA GO:0005654 nucleoplasm TAS GO:0005654 nucleoplasm ISS GO:0005737 cytoplasm IEA GO:0005739 mitochondrion TAS GO:0005829 cytosol IDA 23376485 extracellular exosome GO:0070062,"DNA damage checkpoint GO:0000077 IEA activation of MAPK activity GO:0000187 TAS cell morphogenesis GO:0000902 IEA cartilage condensation GO:0001502 IEA angiogenesis GO:0001525 IEA placenta development GO:0001890 IEA chondrocyte differentiation GO:0002062 IEA glucose metabolic process GO:0006006 IEA transcription, DNA-templated GO:0006351 IEA regulation of transcription from RNA polymerase II promoter GO:0006357 ISS apoptotic process GO:0006915 IEA movement of cell or subcellular component GO:0006928 10912793 TAS chemotaxis GO:0006935 10706854 TAS signal transduction GO:0007165 10706854 TAS cell surface receptor signaling pathway GO:0007166 10706854 TAS transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 IEA Ras protein signal transduction GO:0007265 TAS skeletal muscle tissue development GO:0007519 IEA response to glucose GO:0009749 IEA positive regulation of gene expression GO:0010628 25754930 IMP positive regulation of myotube differentiation GO:0010831 ISS myoblast differentiation involved in skeletal muscle regeneration GO:0014835 IEA peptidyl-serine phosphorylation GO:0018105 ISS fatty acid oxidation GO:0019395 IEA osteoclast differentiation GO:0030316 ISS positive regulation of cyclase activity GO:0031281 22027397 IMP lipopolysaccharide-mediated signaling pathway GO:0031663 IEA response to muramyl dipeptide GO:0032495 IEA intracellular signal transduction GO:0035556 10838079 IDA cellular response to vascular endothelial growth factor stimulus GO:0035924 18440775 IMP response to muscle stretch GO:0035994 IEA p38MAPK cascade GO:0038066 ISS positive regulation of protein import into nucleus GO:0042307 IEA signal transduction in response to DNA damage GO:0042770 20160708 IMP positive regulation of blood vessel endothelial cell migration GO:0043536 18440775 IMP NOT positive regulation of erythrocyte differentiation GO:0045648 23483889 IMP positive regulation of myoblast differentiation GO:0045663 ISS positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA positive regulation of glucose import GO:0046326 IEA protein autophosphorylation GO:0046777 IEA vascular endothelial growth factor receptor signaling pathway GO:0048010 18440775 IMP vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS regulation of sequence-specific DNA binding transcription factor activity GO:0051090 TAS striated muscle cell differentiation GO:0051146 IEA positive regulation of muscle cell differentiation GO:0051149 TAS positive regulation of cardiac muscle cell proliferation GO:0060045 IEA 3'-UTR-mediated mRNA stabilization GO:0070935 20932473 TAS cellular response to lipopolysaccharide GO:0071222 23776175 IDA cellular response to ionizing radiation GO:0071479 20160708 IMP negative regulation of canonical Wnt signaling pathway GO:0090090 IEA positive regulation of brown fat cell differentiation GO:0090336 IEA stress-induced premature senescence GO:0090400 20160708 IMP cellular response to virus GO:0098586 25754930 IMP regulation of cytokine production involved in inflammatory response GO:1900015 15251176 IDA positive regulation of myoblast fusion GO:1901741 ISS regulation of signal transduction by p53 class mediator GO:1901796 TAS positive regulation of reactive oxygen species metabolic process GO:2000379 20160708 IMP positive regulation of interleukin-12 secretion GO:2001184 25754930 IMP",GO:0004674 protein serine/threonine kinase activity TAS 7997261 10330143 20932473 GO:0004707 MAP kinase activity IDA 10706854 GO:0004708 MAP kinase kinase activity TAS 9792677 10415025 10601328 11238443 16189514 16751104 17255097 17255949 17380123 17380128 18624398 20347885 20368287 20871633 20936779 21283629 21900206 21908610 21911040 21988832 22521293 23397142 23455922 23560844 23602568 25241761 25852190 26496610 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0008022 protein C-terminus binding IEA 23483889 GO:0019899 enzyme binding IPI 21283629 GO:0019903 protein phosphatase binding IPI GO:0051525 NFAT protein binding ISS,hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04071 Sphingolipid signaling pathway - Homo sapiens (human) hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04370 VEGF signaling pathway - Homo sapiens (human) hsa04380 Osteoclast differentiation - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04611 Platelet activation - Homo sapiens (human) hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human) hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human) hsa04660 T cell receptor signaling pathway - Homo sapiens (human) hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04668 TNF signaling pathway - Homo sapiens (human) hsa04670 Leukocyte transendothelial migration - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04728 Dopaminergic synapse - Homo sapiens (human) hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04912 GnRH signaling pathway - Homo sapiens (human) hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa05014 Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) hsa05131 Shigellosis - Homo sapiens (human) hsa05132 Salmonella infection - Homo sapiens (human) hsa05133 Pertussis - Homo sapiens (human) hsa05140 Leishmaniasis - Homo sapiens (human) hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05152 Tuberculosis - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05169 Epstein-Barr virus infection - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human),chemicalprobes.org XMD8-92,Q13164,Mitogen-activated protein kinase 7,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,5598,MK07,Signal Transduction R-HSA-162582 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 Activated TLR4 signalling R-HSA-166054 MyD88:Mal cascade initiated on plasma membrane R-HSA-166058 MyD88-independent TLR3/TLR4 cascade R-HSA-166166 Signalling by NGF R-HSA-166520 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168180 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Toll-Like Receptors Cascades R-HSA-168898 Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Nuclear Events (kinase and transcription factor activation) R-HSA-198725 ERK/MAPK targets R-HSA-198753 Signalling to ERK5 R-HSA-198765 ERKs are inactivated R-HSA-202670 Cellular responses to stress R-HSA-2262752 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 Cellular Senescence R-HSA-2559583 Signaling by GPCR R-HSA-372790 MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 MAP kinase activation in TLR cascade R-HSA-450294 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 TRIF-mediated TLR3/TLR4 signaling R-HSA-937061 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 MyD88 dependent cascade initiated on endosome R-HSA-975155 MyD88 cascade initiated on plasma membrane R-HSA-975871,nucleus 18588859 22869143 23043106 GO:0005634 IDA nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS cytoplasm 22869143 GO:0005737 IDA cytosol 23043106 GO:0005829 IDA cytosol GO:0005829 TAS PML body 22869143 GO:0016605 IDA,GO:0000165 MAPK cascade IEA GO:0007049 cell cycle IEA GO:0007165 signal transduction 7646528 TAS GO:0018105 peptidyl-serine phosphorylation IEA GO:0019933 cAMP-mediated signaling 16177794 NAS GO:0030154 cell differentiation IEA GO:0030821 negative regulation of cAMP catabolic process 16177794 NAS GO:0034115 negative regulation of heterotypic cell-cell adhesion 20551324 IGI GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress 23043106 IMP GO:0043407 negative regulation of MAP kinase activity IEA GO:0045765 regulation of angiogenesis IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter 20551324 IGI GO:0050728 negative regulation of inflammatory response 20551324 TAS GO:0051247 positive regulation of protein metabolic process 20551324 IGI GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity 16177794 NAS GO:0051534 negative regulation of NFAT protein import into nucleus IEA GO:0060761 negative regulation of response to cytokine stimulus 20551324 IGI GO:0070301 cellular response to hydrogen peroxide 23043106 IMP GO:0070377 negative regulation of ERK5 cascade IEA GO:0071363 cellular response to growth factor stimulus 20551324 IGI GO:0071499 cellular response to laminar fluid shear stress 23043106 IMP GO:0071499 cellular response to laminar fluid shear stress 20551324 TAS GO:0071560 cellular response to transforming growth factor beta stimulus 18588859 IDA GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 23043106 IMP GO:2000352 negative regulation of endothelial cell apoptotic process 23043106 IMP GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 20551324 IGI,protein serine/threonine kinase activity GO:0004674 TAS MAP kinase activity GO:0004707 IEA protein binding GO:0005515 IPI 7759517 18588859 20832753 22869143 25416956 ATP binding GO:0005524 IEA mitogen-activated protein kinase binding GO:0051019 IPI 23043106,hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04540 Gap junction - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa04912 GnRH signaling pathway - Homo sapiens (human) hsa04921 Oxytocin signaling pathway - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human),chemicalprobes.org URMC-099,Q02779,Mitogen-activated protein kinase kinase kinase 10,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,4294,M3K10,,GO:0005737 cytoplasm 18455992 IDA,"apoptotic process 10801775 GO:0006915 TAS signal transduction 10801775 GO:0007165 TAS smoothened signaling pathway 18455992 GO:0007224 IMP JNK cascade 10801775 GO:0007254 TAS activation of JNKK activity GO:0007256 IEA activation of JUN kinase activity 8195146 GO:0007257 ISS peptidyl-serine phosphorylation 19801649 GO:0018105 IDA peptidyl-threonine phosphorylation 19801649 GO:0018107 IDA positive regulation of apoptotic process GO:0043065 IEA negative regulation of sequence-specific DNA binding transcription factor activity 19801649 GO:0043433 IMP positive regulation of JUN kinase activity 17584736 GO:0043507 IMP negative regulation of transcription, DNA-templated 19801649 GO:0045892 IMP negative regulation of transcription, DNA-templated GO:0045892 ISS positive regulation of JNK cascade 17584736 GO:0046330 IMP protein autophosphorylation 8195146 GO:0046777 ISS",transcription corepressor activity GO:0003714 ISS protein kinase activity GO:0004672 8536694 10801775 TAS protein serine/threonine kinase activity GO:0004674 19801649 IDA JUN kinase kinase kinase activity GO:0004706 ISS ATP binding GO:0005524 IEA protein homodimerization activity GO:0042803 8195146 ISS bHLH transcription factor binding GO:0043425 19801649 IPI,,chemicalprobes.org URMC-099,Q16584,Mitogen-activated protein kinase kinase kinase 11,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,4296,M3K11,"R-HSA-112399 IRS-mediated signalling R-HSA-112412 SOS-mediated signalling R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250196 SHC1 events in ERBB2 signaling R-HSA-1250347 SHC1 events in ERBB4 signaling R-HSA-1266738 Developmental Biology R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1433557 Signaling by SCF-KIT R-HSA-162582 Signal Transduction R-HSA-166520 Signalling by NGF R-HSA-167044 Signalling to RAS R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-169893 Prolonged ERK activation events R-HSA-170968 Frs2-mediated activation R-HSA-170984 ARMS-mediated activation R-HSA-177929 Signaling by EGFR R-HSA-179812 GRB2 events in EGFR signaling R-HSA-180336 SHC1 events in EGFR signaling R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-187687 Signalling to ERKs R-HSA-187706 Signalling to p38 via RIT and RIN R-HSA-190236 Signaling by FGFR R-HSA-194138 Signaling by VEGF R-HSA-1963640 GRB2 events in ERBB2 signaling R-HSA-2172127 DAP12 interactions R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2586552 Signaling by Leptin R-HSA-2871796 FCERI mediated MAPK activation R-HSA-372790 Signaling by GPCR R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-422475 Axon guidance R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5673000 RAF activation R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5683057 MAPK family signaling cascades R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-912526 Interleukin receptor SHC signaling",cytoplasm GO:0005737 IEA centrosome GO:0005813 IDA 12529434 microtubule GO:0005874 IDA 12529434 membrane GO:0016020 IDA 19946888,15258589 GO:0000187 activation of MAPK activity IMP 11053428 GO:0006468 protein phosphorylation IDA 12529434 GO:0007017 microtubule-based process IMP 10799501 GO:0007254 JNK cascade TAS GO:0007256 activation of JNKK activity IEA 15258589 GO:0007257 activation of JUN kinase activity IMP GO:0008219 cell death IEA 15258589 GO:0008283 cell proliferation IMP 17584736 GO:0043507 positive regulation of JUN kinase activity IMP GO:0043525 positive regulation of neuron apoptotic process IEA 17584736 GO:0046330 positive regulation of JNK cascade IMP 8195146 GO:0046777 protein autophosphorylation IDA,8183572 10799501 GO:0004672 protein kinase activity TAS 8195146 GO:0004674 protein serine/threonine kinase activity IDA GO:0004706 JUN kinase kinase kinase activity ISS 9003777 20890305 23857585 25241761 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0031434 mitogen-activated protein kinase kinase binding IEA 17584736 GO:0031435 mitogen-activated protein kinase kinase kinase binding IPI 9829970 GO:0042802 identical protein binding IPI 9829970 GO:0042803 protein homodimerization activity IPI GO:0048365 Rac GTPase binding IEA,MAPK signaling pathway - Homo sapiens (human) hsa04010 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa04932,chemicalprobes.org URMC-099,P80192,Mitogen-activated protein kinase kinase kinase 9,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,4293,M3K9,,cellular_component ND GO:0005575 intracellular IEA GO:0005622,"transcription, DNA-templated GO:0006351 IEA regulation of transcription, DNA-templated GO:0006355 IEA protein phosphorylation GO:0006468 15610029 IDA apoptotic process GO:0006915 IEA activation of JNKK activity GO:0007256 IEA activation of JUN kinase activity GO:0007257 8195146 ISS positive regulation of apoptotic process GO:0043065 IEA protein autophosphorylation GO:0046777 15610029 IDA",15610029 IDA GO:0004674 protein serine/threonine kinase activity ISS GO:0004706 JUN kinase kinase kinase activity 8477742 NAS GO:0004708 MAP kinase kinase activity 22939624 IPI GO:0005515 protein binding IEA GO:0005524 ATP binding 8195146 ISS GO:0042803 protein homodimerization activity,,chemicalprobes.org ABPA3,Q8TBC4,NEDD8-activating enzyme E1 catalytic subunit,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,9039,UBA3,R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983169 Class I MHC mediated antigen processing & presentation,nucleus GO:0005634 IBA nucleus GO:0005634 IDA cytosol GO:0005829 IBA cytosol GO:0005829 TAS,"9694792 GO:0006464 cellular protein modification process TAS 9694792 GO:0006508 proteolysis TAS GO:0007113 endomitotic cell cycle IEA GO:0038061 NIK/NF-kappaB signaling TAS GO:0045116 protein neddylation IBA GO:0045116 protein neddylation IEA GO:0045892 negative regulation of transcription, DNA-templated IEA GO:0051726 regulation of cell cycle IEA",10722740 15361859 15694336 16712842 19250909 19549727 25416956 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0016881 acid-amino acid ligase activity IEA GO:0016922 ligand-dependent nuclear receptor binding IEA 10207026 GO:0019781 NEDD8 activating enzyme activity IDA 12740388 GO:0046982 protein heterodimerization activity IPI,Ubiquitin mediated proteolysis - Homo sapiens (human) hsa04120,chemicalprobes.org BAY-598,Q9NRG4,N-lysine methyltransferase SMYD2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,56950,SMYD2,R-HSA-3214841 PKMTs methylate histone lysines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization,nucleus GO:0005634 ISS nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 ISS cytosol GO:0005829 ISS,"negative regulation of transcription from RNA polymerase II promoter IMP 17108971 GO:0000122 transcription, DNA-templated IEA GO:0006351 heart development IEA GO:0007507 negative regulation of cell proliferation ISS GO:0008285 histone H3-K36 methylation IEA GO:0010452 peptidyl-lysine monomethylation IDA 17108971 20870719 GO:0018026 peptidyl-lysine dimethylation ISS GO:0018027 regulation of DNA damage response, signal transduction by p53 class mediator IMP 17108971 GO:0043516 regulation of signal transduction by p53 class mediator TAS GO:1901796",RNA polymerase II core binding GO:0000993 ISS p53 binding GO:0002039 IPI 17108971 protein binding GO:0005515 IPI 20870719 lysine N-methyltransferase activity GO:0016278 TAS protein-lysine N-methyltransferase activity GO:0016279 IDA 17108971 20870719 histone-lysine N-methyltransferase activity GO:0018024 TAS metal ion binding GO:0046872 IEA histone methyltransferase activity (H3-K36 specific) GO:0046975 ISS,,chemicalprobes.org LLY-507,Q9NRG4,N-lysine methyltransferase SMYD2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,56950,SMYD2,R-HSA-3214841 PKMTs methylate histone lysines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization,nucleus GO:0005634 ISS nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 ISS cytosol GO:0005829 ISS,"negative regulation of transcription from RNA polymerase II promoter IMP 17108971 GO:0000122 transcription, DNA-templated IEA GO:0006351 heart development IEA GO:0007507 negative regulation of cell proliferation ISS GO:0008285 histone H3-K36 methylation IEA GO:0010452 peptidyl-lysine monomethylation IDA 17108971 20870719 GO:0018026 peptidyl-lysine dimethylation ISS GO:0018027 regulation of DNA damage response, signal transduction by p53 class mediator IMP 17108971 GO:0043516 regulation of signal transduction by p53 class mediator TAS GO:1901796",RNA polymerase II core binding GO:0000993 ISS p53 binding GO:0002039 IPI 17108971 protein binding GO:0005515 IPI 20870719 lysine N-methyltransferase activity GO:0016278 TAS protein-lysine N-methyltransferase activity GO:0016279 IDA 17108971 20870719 histone-lysine N-methyltransferase activity GO:0018024 TAS metal ion binding GO:0046872 IEA histone methyltransferase activity (H3-K36 specific) GO:0046975 ISS,,chemicalprobes.org WZ4003,O60285,NUAK family SNF1-like kinase 1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,9891,NUAK1,,nucleus GO:0005634 21317932 IDA nucleoplasm GO:0005654 TAS nucleolus GO:0005730 IDA cytoplasm GO:0005737 21317932 IDA microtubule cytoskeleton GO:0015630 IDA,protein phosphorylation IDA 25329316 GO:0006468 cellular response to DNA damage stimulus IEA GO:0006974 cell adhesion IEA GO:0007155 regulation of cell adhesion IDA 20354225 GO:0030155 regulation of myosin-light-chain-phosphatase activity IDA 20354225 GO:0035507 intracellular signal transduction IBA GO:0035556 regulation of cell proliferation TAS 21317932 GO:0042127 regulation of signal transduction by p53 class mediator TAS GO:1901796 regulation of cellular senescence IDA 19927127 GO:2000772,GO:0002039 p53 binding 21317932 IPI GO:0004674 protein serine/threonine kinase activity 19927127 20354225 21317932 IDA GO:0004674 protein serine/threonine kinase activity TAS GO:0005515 protein binding 19927127 20354225 21317932 25329316 IPI GO:0005524 ATP binding IEA GO:0046872 metal ion binding IEA,,chemicalprobes.org WZ4003,Q9H093,NUAK family SNF1-like kinase 2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,81788,NUAK2,,nucleus GO:0005634 IBA cytoplasm GO:0005737 IBA,GO:0006468 protein phosphorylation 14976552 IDA GO:0006915 apoptotic process IEA GO:0030036 actin cytoskeleton organization 14575707 IDA GO:0035556 intracellular signal transduction IBA GO:0042149 cellular response to glucose starvation 14575707 IDA GO:0043066 negative regulation of apoptotic process 15345718 IDA,magnesium ion binding GO:0000287 IDA 14976552 protein serine/threonine kinase activity GO:0004674 IDA 14976552 19927127 protein binding GO:0005515 IPI 19927127 ATP binding GO:0005524 IDA 14976552,,chemicalprobes.org BYL-719,P42336,PI3-kinase p110-alpha subunit,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,5290,PK3CA,"R-HSA-109582 Hemostasis R-HSA-109704 PI3K Cascade R-HSA-112399 IRS-mediated signalling R-HSA-114604 GPVI-mediated activation cascade R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1226099 Signaling by FGFR in disease R-HSA-1227986 Signaling by ERBB2 R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236394 Signaling by ERBB4 R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-1430728 Metabolism R-HSA-1433557 Signaling by SCF-KIT R-HSA-1483255 PI Metabolism R-HSA-1483257 Phospholipid metabolism R-HSA-1500931 Cell-Cell communication R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-1643713 Signaling by EGFR in Cancer R-HSA-1660499 Synthesis of PIPs at the plasma membrane R-HSA-166520 Signalling by NGF R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-177929 Signaling by EGFR R-HSA-180292 GAB1 signalosome R-HSA-1839117 Signaling by FGFR1 fusion mutants R-HSA-1839124 FGFR1 mutant receptor activation R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-190236 Signaling by FGFR R-HSA-194138 Signaling by VEGF R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-202403 TCR signaling R-HSA-202424 Downstream TCR signaling R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029485 Role of phospholipids in phagocytosis R-HSA-210993 Tie2 Signaling R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-372790 Signaling by GPCR R-HSA-373753 Nephrin interactions R-HSA-388396 GPCR downstream signaling R-HSA-388841 Costimulation by the CD28 family R-HSA-389356 CD28 co-stimulation R-HSA-389357 CD28 dependent PI3K/Akt signaling R-HSA-392451 G beta:gamma signalling through PI3Kgamma R-HSA-397795 G-protein beta:gamma signalling R-HSA-416476 G alpha (q) signalling events R-HSA-416482 G alpha (12/13) signalling events R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-5637810 Constitutive Signaling by EGFRvIII R-HSA-5637812 Signaling by EGFRvIII in Cancer R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5655253 Signaling by FGFR2 in disease R-HSA-5655272 Signaling by FGFR3 mutants R-HSA-5655291 Signaling by FGFR4 in disease R-HSA-5655302 Signaling by FGFR1 in disease R-HSA-5655304 Signaling by FGFR2 mutants R-HSA-5655311 Signaling by FGFR1 mutants R-HSA-5655324 Signaling by FGFR4 mutants R-HSA-5655332 Signaling by FGFR3 in disease R-HSA-5663202 Diseases of signal transduction R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-912526 Interleukin receptor SHC signaling R-HSA-912631 Regulation of signaling by CBL R-HSA-983705 Signaling by the B Cell Receptor (BCR)","cytosol TAS GO:0005829 plasma membrane IBA GO:0005886 phosphatidylinositol 3-kinase complex ISS GO:0005942 phosphatidylinositol 3-kinase complex, class IA IDA 22402981 GO:0005943 lamellipodium IEA GO:0030027",angiogenesis GO:0001525 IEA liver development GO:0001889 IEA vasculature development GO:0001944 TAS 19200708 glucose metabolic process GO:0006006 IEA protein phosphorylation GO:0006468 IEA phosphatidylinositol biosynthetic process GO:0006661 TAS epidermal growth factor receptor signaling pathway GO:0007173 TAS regulation of gene expression GO:0010468 IEA regulation of phosphatidylinositol 3-kinase signaling GO:0014066 TAS platelet activation GO:0030168 TAS 21035500 T cell costimulation GO:0031295 TAS activation of protein kinase activity GO:0032147 IEA positive regulation of peptidyl-serine phosphorylation GO:0033138 IEA phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IEA insulin receptor signaling pathway via phosphatidylinositol 3-kinase GO:0038028 TAS 19200708 Fc-epsilon receptor signaling pathway GO:0038095 TAS Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS ERBB2 signaling pathway GO:0038128 TAS regulation of multicellular organism growth GO:0040014 IEA regulation of cellular respiration GO:0043457 IEA protein kinase B signaling GO:0043491 IEA negative regulation of neuron apoptotic process GO:0043524 IEA endothelial cell migration GO:0043542 TAS 19200708 hypomethylation of CpG island GO:0044029 IEA phosphatidylinositol phosphorylation GO:0046854 ISS vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS phosphatidylinositol-mediated signaling GO:0048015 TAS T cell receptor signaling pathway GO:0050852 TAS leukocyte migration GO:0050900 TAS cardiac muscle contraction GO:0060048 TAS 19147653 adipose tissue development GO:0060612 IEA cellular response to glucose stimulus GO:0071333 IEA energy homeostasis GO:0097009 IEA mitophagy in response to mitochondrial depolarization GO:0098779 IGI 22020285 negative regulation of fibroblast apoptotic process GO:2000270 IEA regulation of genetic imprinting GO:2000653 IEA negative regulation of anoikis GO:2000811 IMP 22402981,"IEA GO:0004674 protein serine/threonine kinase activity 10490823 16043515 17475214 19411071 19574958 20018188 22402981 23643389 23676467 24189400 25814554 26496610 IPI GO:0005515 protein binding IEA GO:0005524 ATP binding TAS GO:0016301 kinase activity 2174051 IDA GO:0016303 1-phosphatidylinositol-3-kinase activity TAS GO:0016303 1-phosphatidylinositol-3-kinase activity IEA GO:0030295 protein kinase activator activity ISS GO:0035004 phosphatidylinositol 3-kinase activity 19200708 TAS GO:0035004 phosphatidylinositol 3-kinase activity IBA GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA GO:0043560 insulin receptor substrate binding IBA GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity",hsa00562 Inositol phosphate metabolism - Homo sapiens (human) hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human) hsa04071 Sphingolipid signaling pathway - Homo sapiens (human) hsa04150 mTOR signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04152 AMPK signaling pathway - Homo sapiens (human) hsa04210 Apoptosis - Homo sapiens (human) hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04370 VEGF signaling pathway - Homo sapiens (human) hsa04380 Osteoclast differentiation - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04611 Platelet activation - Homo sapiens (human) hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04660 T cell receptor signaling pathway - Homo sapiens (human) hsa04662 B cell receptor signaling pathway - Homo sapiens (human) hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04668 TNF signaling pathway - Homo sapiens (human) hsa04670 Leukocyte transendothelial migration - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human) hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04910 Insulin signaling pathway - Homo sapiens (human) hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04915 Estrogen signaling pathway - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04921 Oxytocin signaling pathway - Homo sapiens (human) hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04930 Type II diabetes mellitus - Homo sapiens (human) hsa04932 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human) hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human) hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05146 Amoebiasis - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human) hsa05161 Hepatitis B - Homo sapiens (human) hsa05162 Measles - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05166 HTLV-I infection - Homo sapiens (human) hsa05169 Epstein-Barr virus infection - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05210 Colorectal cancer - Homo sapiens (human) hsa05211 Renal cell carcinoma - Homo sapiens (human) hsa05212 Pancreatic cancer - Homo sapiens (human) hsa05213 Endometrial cancer - Homo sapiens (human) hsa05214 Glioma - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05218 Melanoma - Homo sapiens (human) hsa05220 Chronic myeloid leukemia - Homo sapiens (human) hsa05221 Acute myeloid leukemia - Homo sapiens (human) hsa05222 Small cell lung cancer - Homo sapiens (human) hsa05223 Non-small cell lung cancer - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human) hsa05231 Choline metabolism in cancer - Homo sapiens (human),chemicalprobes.org GDC-0941,P42336,PI3-kinase p110-alpha subunit,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,5290,PK3CA,"R-HSA-109582 Hemostasis R-HSA-109704 PI3K Cascade R-HSA-112399 IRS-mediated signalling R-HSA-114604 GPVI-mediated activation cascade R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1226099 Signaling by FGFR in disease R-HSA-1227986 Signaling by ERBB2 R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236394 Signaling by ERBB4 R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-1430728 Metabolism R-HSA-1433557 Signaling by SCF-KIT R-HSA-1483255 PI Metabolism R-HSA-1483257 Phospholipid metabolism R-HSA-1500931 Cell-Cell communication R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-1643713 Signaling by EGFR in Cancer R-HSA-1660499 Synthesis of PIPs at the plasma membrane R-HSA-166520 Signalling by NGF R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-177929 Signaling by EGFR R-HSA-180292 GAB1 signalosome R-HSA-1839117 Signaling by FGFR1 fusion mutants R-HSA-1839124 FGFR1 mutant receptor activation R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-190236 Signaling by FGFR R-HSA-194138 Signaling by VEGF R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-202403 TCR signaling R-HSA-202424 Downstream TCR signaling R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029485 Role of phospholipids in phagocytosis R-HSA-210993 Tie2 Signaling R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-372790 Signaling by GPCR R-HSA-373753 Nephrin interactions R-HSA-388396 GPCR downstream signaling R-HSA-388841 Costimulation by the CD28 family R-HSA-389356 CD28 co-stimulation R-HSA-389357 CD28 dependent PI3K/Akt signaling R-HSA-392451 G beta:gamma signalling through PI3Kgamma R-HSA-397795 G-protein beta:gamma signalling R-HSA-416476 G alpha (q) signalling events R-HSA-416482 G alpha (12/13) signalling events R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-5637810 Constitutive Signaling by EGFRvIII R-HSA-5637812 Signaling by EGFRvIII in Cancer R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5655253 Signaling by FGFR2 in disease R-HSA-5655272 Signaling by FGFR3 mutants R-HSA-5655291 Signaling by FGFR4 in disease R-HSA-5655302 Signaling by FGFR1 in disease R-HSA-5655304 Signaling by FGFR2 mutants R-HSA-5655311 Signaling by FGFR1 mutants R-HSA-5655324 Signaling by FGFR4 mutants R-HSA-5655332 Signaling by FGFR3 in disease R-HSA-5663202 Diseases of signal transduction R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-912526 Interleukin receptor SHC signaling R-HSA-912631 Regulation of signaling by CBL R-HSA-983705 Signaling by the B Cell Receptor (BCR)","cytosol TAS GO:0005829 plasma membrane IBA GO:0005886 phosphatidylinositol 3-kinase complex ISS GO:0005942 phosphatidylinositol 3-kinase complex, class IA IDA 22402981 GO:0005943 lamellipodium IEA GO:0030027",angiogenesis GO:0001525 IEA liver development GO:0001889 IEA vasculature development GO:0001944 TAS 19200708 glucose metabolic process GO:0006006 IEA protein phosphorylation GO:0006468 IEA phosphatidylinositol biosynthetic process GO:0006661 TAS epidermal growth factor receptor signaling pathway GO:0007173 TAS regulation of gene expression GO:0010468 IEA regulation of phosphatidylinositol 3-kinase signaling GO:0014066 TAS platelet activation GO:0030168 TAS 21035500 T cell costimulation GO:0031295 TAS activation of protein kinase activity GO:0032147 IEA positive regulation of peptidyl-serine phosphorylation GO:0033138 IEA phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IEA insulin receptor signaling pathway via phosphatidylinositol 3-kinase GO:0038028 TAS 19200708 Fc-epsilon receptor signaling pathway GO:0038095 TAS Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS ERBB2 signaling pathway GO:0038128 TAS regulation of multicellular organism growth GO:0040014 IEA regulation of cellular respiration GO:0043457 IEA protein kinase B signaling GO:0043491 IEA negative regulation of neuron apoptotic process GO:0043524 IEA endothelial cell migration GO:0043542 TAS 19200708 hypomethylation of CpG island GO:0044029 IEA phosphatidylinositol phosphorylation GO:0046854 ISS vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS phosphatidylinositol-mediated signaling GO:0048015 TAS T cell receptor signaling pathway GO:0050852 TAS leukocyte migration GO:0050900 TAS cardiac muscle contraction GO:0060048 TAS 19147653 adipose tissue development GO:0060612 IEA cellular response to glucose stimulus GO:0071333 IEA energy homeostasis GO:0097009 IEA mitophagy in response to mitochondrial depolarization GO:0098779 IGI 22020285 negative regulation of fibroblast apoptotic process GO:2000270 IEA regulation of genetic imprinting GO:2000653 IEA negative regulation of anoikis GO:2000811 IMP 22402981,"IEA GO:0004674 protein serine/threonine kinase activity 10490823 16043515 17475214 19411071 19574958 20018188 22402981 23643389 23676467 24189400 25814554 26496610 IPI GO:0005515 protein binding IEA GO:0005524 ATP binding TAS GO:0016301 kinase activity 2174051 IDA GO:0016303 1-phosphatidylinositol-3-kinase activity TAS GO:0016303 1-phosphatidylinositol-3-kinase activity IEA GO:0030295 protein kinase activator activity ISS GO:0035004 phosphatidylinositol 3-kinase activity 19200708 TAS GO:0035004 phosphatidylinositol 3-kinase activity IBA GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA GO:0043560 insulin receptor substrate binding IBA GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity",hsa00562 Inositol phosphate metabolism - Homo sapiens (human) hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human) hsa04071 Sphingolipid signaling pathway - Homo sapiens (human) hsa04150 mTOR signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04152 AMPK signaling pathway - Homo sapiens (human) hsa04210 Apoptosis - Homo sapiens (human) hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04370 VEGF signaling pathway - Homo sapiens (human) hsa04380 Osteoclast differentiation - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04611 Platelet activation - Homo sapiens (human) hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04660 T cell receptor signaling pathway - Homo sapiens (human) hsa04662 B cell receptor signaling pathway - Homo sapiens (human) hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04668 TNF signaling pathway - Homo sapiens (human) hsa04670 Leukocyte transendothelial migration - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human) hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04910 Insulin signaling pathway - Homo sapiens (human) hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04915 Estrogen signaling pathway - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04921 Oxytocin signaling pathway - Homo sapiens (human) hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04930 Type II diabetes mellitus - Homo sapiens (human) hsa04932 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human) hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human) hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05146 Amoebiasis - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human) hsa05161 Hepatitis B - Homo sapiens (human) hsa05162 Measles - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05166 HTLV-I infection - Homo sapiens (human) hsa05169 Epstein-Barr virus infection - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05210 Colorectal cancer - Homo sapiens (human) hsa05211 Renal cell carcinoma - Homo sapiens (human) hsa05212 Pancreatic cancer - Homo sapiens (human) hsa05213 Endometrial cancer - Homo sapiens (human) hsa05214 Glioma - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05218 Melanoma - Homo sapiens (human) hsa05220 Chronic myeloid leukemia - Homo sapiens (human) hsa05221 Acute myeloid leukemia - Homo sapiens (human) hsa05222 Small cell lung cancer - Homo sapiens (human) hsa05223 Non-small cell lung cancer - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human) hsa05231 Choline metabolism in cancer - Homo sapiens (human),chemicalprobes.org GDC-0941,O00329,PI3-kinase p110-delta subunit,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,5293,PK3CD,"R-HSA-109582 Hemostasis R-HSA-114604 GPVI-mediated activation cascade R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-1430728 Metabolism R-HSA-1433557 Signaling by SCF-KIT R-HSA-1483255 PI Metabolism R-HSA-1483257 Phospholipid metabolism R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-1660499 Synthesis of PIPs at the plasma membrane R-HSA-166520 Signalling by NGF R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-177929 Signaling by EGFR R-HSA-180292 GAB1 signalosome R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-190236 Signaling by FGFR R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2424491 DAP12 signaling R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-372790 Signaling by GPCR R-HSA-388396 GPCR downstream signaling R-HSA-392451 G beta:gamma signalling through PI3Kgamma R-HSA-397795 G-protein beta:gamma signalling R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5663202 Diseases of signal transduction R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-912526 Interleukin receptor SHC signaling R-HSA-912631 Regulation of signaling by CBL R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983705 Signaling by the B Cell Receptor (BCR)",GO:0005829 cytosol TAS GO:0005886 plasma membrane IBA GO:0005886 plasma membrane TAS GO:0005942 phosphatidylinositol 3-kinase complex IBA 9113989 9235916 GO:0005942 phosphatidylinositol 3-kinase complex NAS GO:0042629 mast cell granule IEA,natural killer cell differentiation GO:0001779 TAS 20940048 cytokine production GO:0001816 TAS 20940048 adaptive immune response GO:0002250 TAS 17290298 mast cell chemotaxis GO:0002551 TAS 20940048 respiratory burst involved in defense response GO:0002679 TAS 20940048 protein phosphorylation GO:0006468 NAS 9113989 phosphatidylinositol biosynthetic process GO:0006661 TAS inflammatory response GO:0006954 TAS 17290298 20940048 signal transduction GO:0007165 NAS 9113989 positive regulation of gene expression GO:0010628 IMP 22079609 T cell chemotaxis GO:0010818 TAS 20940048 phosphatidylinositol 3-kinase signaling GO:0014065 TAS 17290298 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 TAS natural killer cell activation GO:0030101 TAS 20940048 T cell differentiation GO:0030217 TAS 20940048 positive regulation of cell migration GO:0030335 IMP 22079609 neutrophil chemotaxis GO:0030593 TAS 20940048 natural killer cell chemotaxis GO:0035747 TAS 20940048 B cell chemotaxis GO:0035754 TAS 20940048 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IEA T cell activation GO:0042110 TAS 20940048 B cell activation GO:0042113 TAS 20940048 mast cell degranulation GO:0043303 TAS 20940048 innate immune response GO:0045087 TAS 17290298 20940048 phosphatidylinositol phosphorylation GO:0046854 IEA phosphatidylinositol-mediated signaling GO:0048015 TAS T cell receptor signaling pathway GO:0050852 TAS 20940048 B cell receptor signaling pathway GO:0050853 TAS 20940048 mast cell differentiation GO:0060374 TAS 20940048 neutrophil extravasation GO:0072672 TAS 20940048,"IPI 22020336 protein binding GO:0005515 IEA GO:0005524 ATP binding IBA GO:0016303 1-phosphatidylinositol-3-kinase activity NAS 9235916 1-phosphatidylinositol-3-kinase activity GO:0016303 TAS 17290298 phosphatidylinositol 3-kinase activity GO:0035004 IBA GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity TAS GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity",Inositol phosphate metabolism - Homo sapiens (human) hsa00562 ErbB signaling pathway - Homo sapiens (human) hsa04012 Ras signaling pathway - Homo sapiens (human) hsa04014 Rap1 signaling pathway - Homo sapiens (human) hsa04015 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 cAMP signaling pathway - Homo sapiens (human) hsa04024 Chemokine signaling pathway - Homo sapiens (human) hsa04062 HIF-1 signaling pathway - Homo sapiens (human) hsa04066 FoxO signaling pathway - Homo sapiens (human) hsa04068 Phosphatidylinositol signaling system - Homo sapiens (human) hsa04070 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 mTOR signaling pathway - Homo sapiens (human) hsa04150 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 AMPK signaling pathway - Homo sapiens (human) hsa04152 Apoptosis - Homo sapiens (human) hsa04210 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04261 VEGF signaling pathway - Homo sapiens (human) hsa04370 Osteoclast differentiation - Homo sapiens (human) hsa04380 Focal adhesion - Homo sapiens (human) hsa04510 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04550 Platelet activation - Homo sapiens (human) hsa04611 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04620 Jak-STAT signaling pathway - Homo sapiens (human) hsa04630 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04650 T cell receptor signaling pathway - Homo sapiens (human) hsa04660 B cell receptor signaling pathway - Homo sapiens (human) hsa04662 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04664 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04666 TNF signaling pathway - Homo sapiens (human) hsa04668 Leukocyte transendothelial migration - Homo sapiens (human) hsa04670 Neurotrophin signaling pathway - Homo sapiens (human) hsa04722 Cholinergic synapse - Homo sapiens (human) hsa04725 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04750 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04810 Insulin signaling pathway - Homo sapiens (human) hsa04910 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04914 Estrogen signaling pathway - Homo sapiens (human) hsa04915 Prolactin signaling pathway - Homo sapiens (human) hsa04917 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04919 Oxytocin signaling pathway - Homo sapiens (human) hsa04921 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04923 Type II diabetes mellitus - Homo sapiens (human) hsa04930 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa04932 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) hsa04960 Carbohydrate digestion and absorption - Homo sapiens (human) hsa04973 Bacterial invasion of epithelial cells - Homo sapiens (human) hsa05100 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05142 Toxoplasmosis - Homo sapiens (human) hsa05145 Amoebiasis - Homo sapiens (human) hsa05146 Hepatitis C - Homo sapiens (human) hsa05160 Hepatitis B - Homo sapiens (human) hsa05161 Measles - Homo sapiens (human) hsa05162 Influenza A - Homo sapiens (human) hsa05164 HTLV-I infection - Homo sapiens (human) hsa05166 Epstein-Barr virus infection - Homo sapiens (human) hsa05169 Pathways in cancer - Homo sapiens (human) hsa05200 Viral carcinogenesis - Homo sapiens (human) hsa05203 Proteoglycans in cancer - Homo sapiens (human) hsa05205 Colorectal cancer - Homo sapiens (human) hsa05210 Renal cell carcinoma - Homo sapiens (human) hsa05211 Pancreatic cancer - Homo sapiens (human) hsa05212 Endometrial cancer - Homo sapiens (human) hsa05213 Glioma - Homo sapiens (human) hsa05214 Prostate cancer - Homo sapiens (human) hsa05215 Melanoma - Homo sapiens (human) hsa05218 Chronic myeloid leukemia - Homo sapiens (human) hsa05220 Acute myeloid leukemia - Homo sapiens (human) hsa05221 Small cell lung cancer - Homo sapiens (human) hsa05222 Non-small cell lung cancer - Homo sapiens (human) hsa05223 Central carbon metabolism in cancer - Homo sapiens (human) hsa05230 Choline metabolism in cancer - Homo sapiens (human) hsa05231,chemicalprobes.org CP-673451,P09619,Platelet-derived growth factor receptor beta,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,5159,PGFRB,"R-HSA-112399 IRS-mediated signalling R-HSA-112412 SOS-mediated signalling R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250196 SHC1 events in ERBB2 signaling R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1250347 SHC1 events in ERBB4 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1266738 Developmental Biology R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-1433557 Signaling by SCF-KIT R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-166520 Signalling by NGF R-HSA-167044 Signalling to RAS R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-169893 Prolonged ERK activation events R-HSA-170968 Frs2-mediated activation R-HSA-170984 ARMS-mediated activation R-HSA-177929 Signaling by EGFR R-HSA-179812 GRB2 events in EGFR signaling R-HSA-180292 GAB1 signalosome R-HSA-180336 SHC1 events in EGFR signaling R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-187687 Signalling to ERKs R-HSA-187706 Signalling to p38 via RIT and RIN R-HSA-190236 Signaling by FGFR R-HSA-194138 Signaling by VEGF R-HSA-1963640 GRB2 events in ERBB2 signaling R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2586552 Signaling by Leptin R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-372790 Signaling by GPCR R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-422475 Axon guidance R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5663202 Diseases of signal transduction R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5683057 MAPK family signaling cascades R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-912526 Interleukin receptor SHC signaling R-HSA-983705 Signaling by the B Cell Receptor (BCR)","nucleus GO:0005634 ISS cytoplasm GO:0005737 ISS plasma membrane GO:0005886 TAS focal adhesion GO:0005925 21423176 IDA membrane GO:0016020 16477012 19946888 IDA integral component of membrane GO:0016021 IEA cytoplasmic, membrane-bounded vesicle GO:0016023 IEA apical plasma membrane GO:0016324 ISS intrinsic component of plasma membrane GO:0031226 2554309 IDA lysosomal lumen GO:0043202 IEA extracellular exosome GO:0070062 23376485 IDA",GO:0000165 MAPK cascade TAS GO:0006024 glycosaminoglycan biosynthetic process IEA GO:0007165 signal transduction 10821867 IDA GO:0007186 G-protein coupled receptor signaling pathway IEA GO:0008284 positive regulation of cell proliferation 2554309 IMP GO:0009636 response to toxic substance IEA GO:0010863 positive regulation of phospholipase C activity 1653029 IDA GO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS GO:0014911 positive regulation of smooth muscle cell migration 21679854 IMP GO:0014911 positive regulation of smooth muscle cell migration ISS GO:0016477 cell migration 2554309 IMP GO:0018108 peptidyl-tyrosine phosphorylation 1653029 2536956 2850496 IDA GO:0030335 positive regulation of cell migration 17470632 IDA GO:0032355 response to estradiol IEA GO:0032516 positive regulation of phosphoprotein phosphatase activity 7691811 IDA GO:0032526 response to retinoic acid IEA GO:0032956 regulation of actin cytoskeleton organization ISS GO:0032967 positive regulation of collagen biosynthetic process IEA GO:0034405 response to fluid shear stress IEA GO:0035441 cell migration involved in vasculogenesis ISS GO:0035789 metanephric mesenchymal cell migration IEA GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 2554309 26599395 IMP GO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISS GO:0035909 aorta morphogenesis ISS GO:0036120 cellular response to platelet-derived growth factor stimulus IEA GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway 17470632 IDA GO:0042060 wound healing IEA GO:0042542 response to hydrogen peroxide IEA GO:0043066 negative regulation of apoptotic process IEA GO:0043406 positive regulation of MAP kinase activity ISS GO:0043547 positive regulation of GTPase activity IEA GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 1314164 IDA GO:0045840 positive regulation of mitotic nuclear division ISS GO:0046488 phosphatidylinositol metabolic process 1653029 IMP GO:0046777 protein autophosphorylation 1314164 2536956 2850496 IDA GO:0046854 phosphatidylinositol phosphorylation IEA GO:0048008 platelet-derived growth factor receptor signaling pathway 1314164 2536956 IDA GO:0048015 phosphatidylinositol-mediated signaling 2554309 IMP GO:0048015 phosphatidylinositol-mediated signaling TAS GO:0048661 positive regulation of smooth muscle cell proliferation 21679854 IMP GO:0048661 positive regulation of smooth muscle cell proliferation ISS GO:0048839 inner ear development IEA GO:0050921 positive regulation of chemotaxis ISS GO:0055003 cardiac myofibril assembly ISS GO:0055093 response to hyperoxia IEA GO:0060326 cell chemotaxis 2554309 17991872 IDA GO:0060981 cell migration involved in coronary angiogenesis ISS GO:0061298 retina vasculature development in camera-type eye ISS GO:0070374 positive regulation of ERK1 and ERK2 cascade 21679854 IMP GO:0070374 positive regulation of ERK1 and ERK2 cascade ISS GO:0071670 smooth muscle cell chemotaxis ISS GO:0072075 metanephric mesenchyme development IEA GO:0072262 metanephric glomerular mesangial cell proliferation involved in metanephros development ISS GO:0072277 metanephric glomerular capillary formation ISS GO:0072278 metanephric comma-shaped body morphogenesis IEA GO:0072284 metanephric S-shaped body morphogenesis IEA GO:0090280 positive regulation of calcium ion import ISS GO:2000379 positive regulation of reactive oxygen species metabolic process ISS GO:2000573 positive regulation of DNA biosynthetic process ISS,"GO:0004713 protein tyrosine kinase activity 1653029 IDA GO:0004992 platelet activating factor receptor activity 2536956 TAS GO:0005017 platelet-derived growth factor-activated receptor activity 2536956 TAS GO:0005019 platelet-derived growth factor beta-receptor activity 1314164 2536956 2850496 IDA GO:0005019 platelet-derived growth factor beta-receptor activity 2554309 26599395 IMP GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS GO:0005102 receptor binding 10821867 IPI GO:0005161 platelet-derived growth factor receptor binding 2542288 IPI GO:0005515 protein binding 1314164 1330535 1334459 1375321 1396585 1661130 2157284 7530043 7536927 7679113 7680644 7683666 7685273 7687537 7688466 7692233 7876130 8119896 8181064 8183548 8382612 8382774 8538796 8555205 8564419 8670861 8940081 9153411 9355745 9512716 9742401 10336465 10752619 10806482 10821867 11710529 11896612 12614164 12706723 15641795 16456542 16477012 17242191 17470632 17981115 19167335 19864249 21376233 23397142 24012959 25241761 25416956 IPI GO:0005524 ATP binding IEA GO:0019901 protein kinase binding 16479011 IPI GO:0038085 vascular endothelial growth factor binding 17470632 IPI GO:0043548 phosphatidylinositol 3-kinase binding IEA GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS GO:0048407 platelet-derived growth factor binding 2554309 2850496 IDA GO:0048407 platelet-derived growth factor binding 2536956 IPI",MAPK signaling pathway - Homo sapiens (human) hsa04010 Ras signaling pathway - Homo sapiens (human) hsa04014 Rap1 signaling pathway - Homo sapiens (human) hsa04015 Calcium signaling pathway - Homo sapiens (human) hsa04020 Cytokine-cytokine receptor interaction - Homo sapiens (human) hsa04060 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Focal adhesion - Homo sapiens (human) hsa04510 Gap junction - Homo sapiens (human) hsa04540 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04810 HTLV-I infection - Homo sapiens (human) hsa05166 Pathways in cancer - Homo sapiens (human) hsa05200 MicroRNAs in cancer - Homo sapiens (human) hsa05206 Glioma - Homo sapiens (human) hsa05214 Prostate cancer - Homo sapiens (human) hsa05215 Melanoma - Homo sapiens (human) hsa05218 Central carbon metabolism in cancer - Homo sapiens (human) hsa05230 Choline metabolism in cancer - Homo sapiens (human) hsa05231,chemicalprobes.org Imatinib,P09619,Platelet-derived growth factor receptor beta,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,5159,PGFRB,"R-HSA-112399 IRS-mediated signalling R-HSA-112412 SOS-mediated signalling R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250196 SHC1 events in ERBB2 signaling R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1250347 SHC1 events in ERBB4 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1266738 Developmental Biology R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-1433557 Signaling by SCF-KIT R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-166520 Signalling by NGF R-HSA-167044 Signalling to RAS R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-169893 Prolonged ERK activation events R-HSA-170968 Frs2-mediated activation R-HSA-170984 ARMS-mediated activation R-HSA-177929 Signaling by EGFR R-HSA-179812 GRB2 events in EGFR signaling R-HSA-180292 GAB1 signalosome R-HSA-180336 SHC1 events in EGFR signaling R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-187687 Signalling to ERKs R-HSA-187706 Signalling to p38 via RIT and RIN R-HSA-190236 Signaling by FGFR R-HSA-194138 Signaling by VEGF R-HSA-1963640 GRB2 events in ERBB2 signaling R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2586552 Signaling by Leptin R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-372790 Signaling by GPCR R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-422475 Axon guidance R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5663202 Diseases of signal transduction R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5683057 MAPK family signaling cascades R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-912526 Interleukin receptor SHC signaling R-HSA-983705 Signaling by the B Cell Receptor (BCR)","nucleus GO:0005634 ISS cytoplasm GO:0005737 ISS plasma membrane GO:0005886 TAS focal adhesion GO:0005925 21423176 IDA membrane GO:0016020 16477012 19946888 IDA integral component of membrane GO:0016021 IEA cytoplasmic, membrane-bounded vesicle GO:0016023 IEA apical plasma membrane GO:0016324 ISS intrinsic component of plasma membrane GO:0031226 2554309 IDA lysosomal lumen GO:0043202 IEA extracellular exosome GO:0070062 23376485 IDA",GO:0000165 MAPK cascade TAS GO:0006024 glycosaminoglycan biosynthetic process IEA GO:0007165 signal transduction 10821867 IDA GO:0007186 G-protein coupled receptor signaling pathway IEA GO:0008284 positive regulation of cell proliferation 2554309 IMP GO:0009636 response to toxic substance IEA GO:0010863 positive regulation of phospholipase C activity 1653029 IDA GO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS GO:0014911 positive regulation of smooth muscle cell migration 21679854 IMP GO:0014911 positive regulation of smooth muscle cell migration ISS GO:0016477 cell migration 2554309 IMP GO:0018108 peptidyl-tyrosine phosphorylation 1653029 2536956 2850496 IDA GO:0030335 positive regulation of cell migration 17470632 IDA GO:0032355 response to estradiol IEA GO:0032516 positive regulation of phosphoprotein phosphatase activity 7691811 IDA GO:0032526 response to retinoic acid IEA GO:0032956 regulation of actin cytoskeleton organization ISS GO:0032967 positive regulation of collagen biosynthetic process IEA GO:0034405 response to fluid shear stress IEA GO:0035441 cell migration involved in vasculogenesis ISS GO:0035789 metanephric mesenchymal cell migration IEA GO:0035791 platelet-derived growth factor receptor-beta signaling pathway 2554309 26599395 IMP GO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway ISS GO:0035909 aorta morphogenesis ISS GO:0036120 cellular response to platelet-derived growth factor stimulus IEA GO:0038091 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway 17470632 IDA GO:0042060 wound healing IEA GO:0042542 response to hydrogen peroxide IEA GO:0043066 negative regulation of apoptotic process IEA GO:0043406 positive regulation of MAP kinase activity ISS GO:0043547 positive regulation of GTPase activity IEA GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity 1314164 IDA GO:0045840 positive regulation of mitotic nuclear division ISS GO:0046488 phosphatidylinositol metabolic process 1653029 IMP GO:0046777 protein autophosphorylation 1314164 2536956 2850496 IDA GO:0046854 phosphatidylinositol phosphorylation IEA GO:0048008 platelet-derived growth factor receptor signaling pathway 1314164 2536956 IDA GO:0048015 phosphatidylinositol-mediated signaling 2554309 IMP GO:0048015 phosphatidylinositol-mediated signaling TAS GO:0048661 positive regulation of smooth muscle cell proliferation 21679854 IMP GO:0048661 positive regulation of smooth muscle cell proliferation ISS GO:0048839 inner ear development IEA GO:0050921 positive regulation of chemotaxis ISS GO:0055003 cardiac myofibril assembly ISS GO:0055093 response to hyperoxia IEA GO:0060326 cell chemotaxis 2554309 17991872 IDA GO:0060981 cell migration involved in coronary angiogenesis ISS GO:0061298 retina vasculature development in camera-type eye ISS GO:0070374 positive regulation of ERK1 and ERK2 cascade 21679854 IMP GO:0070374 positive regulation of ERK1 and ERK2 cascade ISS GO:0071670 smooth muscle cell chemotaxis ISS GO:0072075 metanephric mesenchyme development IEA GO:0072262 metanephric glomerular mesangial cell proliferation involved in metanephros development ISS GO:0072277 metanephric glomerular capillary formation ISS GO:0072278 metanephric comma-shaped body morphogenesis IEA GO:0072284 metanephric S-shaped body morphogenesis IEA GO:0090280 positive regulation of calcium ion import ISS GO:2000379 positive regulation of reactive oxygen species metabolic process ISS GO:2000573 positive regulation of DNA biosynthetic process ISS,"GO:0004713 protein tyrosine kinase activity 1653029 IDA GO:0004992 platelet activating factor receptor activity 2536956 TAS GO:0005017 platelet-derived growth factor-activated receptor activity 2536956 TAS GO:0005019 platelet-derived growth factor beta-receptor activity 1314164 2536956 2850496 IDA GO:0005019 platelet-derived growth factor beta-receptor activity 2554309 26599395 IMP GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS GO:0005102 receptor binding 10821867 IPI GO:0005161 platelet-derived growth factor receptor binding 2542288 IPI GO:0005515 protein binding 1314164 1330535 1334459 1375321 1396585 1661130 2157284 7530043 7536927 7679113 7680644 7683666 7685273 7687537 7688466 7692233 7876130 8119896 8181064 8183548 8382612 8382774 8538796 8555205 8564419 8670861 8940081 9153411 9355745 9512716 9742401 10336465 10752619 10806482 10821867 11710529 11896612 12614164 12706723 15641795 16456542 16477012 17242191 17470632 17981115 19167335 19864249 21376233 23397142 24012959 25241761 25416956 IPI GO:0005524 ATP binding IEA GO:0019901 protein kinase binding 16479011 IPI GO:0038085 vascular endothelial growth factor binding 17470632 IPI GO:0043548 phosphatidylinositol 3-kinase binding IEA GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS GO:0048407 platelet-derived growth factor binding 2554309 2850496 IDA GO:0048407 platelet-derived growth factor binding 2536956 IPI",MAPK signaling pathway - Homo sapiens (human) hsa04010 Ras signaling pathway - Homo sapiens (human) hsa04014 Rap1 signaling pathway - Homo sapiens (human) hsa04015 Calcium signaling pathway - Homo sapiens (human) hsa04020 Cytokine-cytokine receptor interaction - Homo sapiens (human) hsa04060 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Focal adhesion - Homo sapiens (human) hsa04510 Gap junction - Homo sapiens (human) hsa04540 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04810 HTLV-I infection - Homo sapiens (human) hsa05166 Pathways in cancer - Homo sapiens (human) hsa05200 MicroRNAs in cancer - Homo sapiens (human) hsa05206 Glioma - Homo sapiens (human) hsa05214 Prostate cancer - Homo sapiens (human) hsa05215 Melanoma - Homo sapiens (human) hsa05218 Central carbon metabolism in cancer - Homo sapiens (human) hsa05230 Choline metabolism in cancer - Homo sapiens (human) hsa05231,chemicalprobes.org Olaparib,P09874,Poly [ADP-ribose] polymerase-1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,142,PARP1,POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 Signal Transduction R-HSA-162582 Signaling by TGF-beta Receptor Complex R-HSA-170834 Generic Transcription Pathway R-HSA-212436 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 SUMOylation R-HSA-2990846 SUMOylation of DNA damage response and repair proteins R-HSA-3108214 SUMO E3 ligases SUMOylate target proteins R-HSA-3108232 Metabolism of proteins R-HSA-392499 Post-translational protein modification R-HSA-597592 Base Excision Repair R-HSA-73884 DNA Repair R-HSA-73894 Resolution of Abasic Sites (AP sites) R-HSA-73933 Gene Expression R-HSA-74160,"19135898 GO:0000784 nuclear chromosome, telomeric region IDA 17177976 GO:0005634 nucleus IDA 9518481 GO:0005635 nuclear envelope IDA GO:0005654 nucleoplasm TAS 19303849 GO:0005667 transcription factor complex IDA 9518481 16107709 GO:0005730 nucleolus IDA 25378300 GO:0005739 mitochondrion IDA 19946888 GO:0016020 membrane IDA 25378300 GO:0043234 protein complex IDA","GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS GO:0000715 nucleotide-excision repair, DNA damage recognition TAS GO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS GO:0000724 double-strand break repair via homologous recombination TAS GO:0006273 lagging strand elongation IBA GO:0006281 DNA repair 17396150 TAS GO:0006293 nucleotide-excision repair, preincision complex stabilization TAS GO:0006294 nucleotide-excision repair, preincision complex assembly TAS GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion TAS GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion TAS GO:0006302 double-strand break repair 23230272 IMP GO:0006366 transcription from RNA polymerase II promoter 10944198 TAS GO:0006471 protein ADP-ribosylation 17396150 IDA GO:0006974 cellular response to DNA damage stimulus 24550317 IMP GO:0007005 mitochondrion organization 25378300 IMP GO:0007179 transforming growth factor beta receptor signaling pathway IEA GO:0010613 positive regulation of cardiac muscle hypertrophy ISS GO:0016540 protein autoprocessing IEA GO:0016925 protein sumoylation TAS GO:0023019 signal transduction involved in regulation of gene expression IEA GO:0030225 macrophage differentiation 18309324 TAS GO:0032042 mitochondrial DNA metabolic process 25378300 IMP GO:0032869 cellular response to insulin stimulus 19303849 IDA GO:0033683 nucleotide-excision repair, DNA incision TAS GO:0034599 cellular response to oxidative stress 25378300 IMP GO:0036211 protein modification process 25378300 IMP GO:0042769 DNA damage response, detection of DNA damage IEA GO:0043504 mitochondrial DNA repair 25378300 IMP GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0051103 DNA ligation involved in DNA repair IBA GO:0060391 positive regulation of SMAD protein import into nucleus IEA GO:0070212 protein poly-ADP-ribosylation 15674325 19470756 IDA GO:0070911 global genome nucleotide-excision repair TAS GO:1903827 regulation of cellular protein localization 24550317 IMP GO:1904357 negative regulation of telomere maintenance via telomere lengthening ISS GO:2000679 positive regulation of transcription regulatory region DNA binding IEA",IEA GO:0003677 DNA binding IBA GO:0003910 DNA ligase (ATP) activity IDA 16107709 17396150 19470756 23275542 NAD+ ADP-ribosyltransferase activity GO:0003950 TAS GO:0003950 NAD+ ADP-ribosyltransferase activity IPI 9518481 11248244 14596914 14627987 14734561 15044383 15555565 16490787 17396150 18172500 18971944 19661379 19779455 21266351 21549307 21575865 21577210 22863007 23230272 23481255 24778456 25640309 protein binding GO:0005515 IPI 19303849 transcription factor binding GO:0008134 IEA GO:0008270 zinc ion binding IPI 23382074 enzyme binding GO:0019899 IPI 17177976 protein kinase binding GO:0019901 IPI 14734561 23481255 identical protein binding GO:0042802 IEA GO:0042826 histone deacetylase binding IDA 22658674 22681889 poly(A) RNA binding GO:0044822 IPI 16107709 protein N-terminus binding GO:0047485 IEA GO:0051287 NAD binding IEA GO:0070412 R-SMAD binding,Base excision repair - Homo sapiens (human) hsa03410 NF-kappa B signaling pathway - Homo sapiens (human) hsa04064,chemicalprobes.org MK-4827,P09874,Poly [ADP-ribose] polymerase-1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,142,PARP1,POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 Signal Transduction R-HSA-162582 Signaling by TGF-beta Receptor Complex R-HSA-170834 Generic Transcription Pathway R-HSA-212436 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 SUMOylation R-HSA-2990846 SUMOylation of DNA damage response and repair proteins R-HSA-3108214 SUMO E3 ligases SUMOylate target proteins R-HSA-3108232 Metabolism of proteins R-HSA-392499 Post-translational protein modification R-HSA-597592 Base Excision Repair R-HSA-73884 DNA Repair R-HSA-73894 Resolution of Abasic Sites (AP sites) R-HSA-73933 Gene Expression R-HSA-74160,"19135898 GO:0000784 nuclear chromosome, telomeric region IDA 17177976 GO:0005634 nucleus IDA 9518481 GO:0005635 nuclear envelope IDA GO:0005654 nucleoplasm TAS 19303849 GO:0005667 transcription factor complex IDA 9518481 16107709 GO:0005730 nucleolus IDA 25378300 GO:0005739 mitochondrion IDA 19946888 GO:0016020 membrane IDA 25378300 GO:0043234 protein complex IDA","GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS GO:0000715 nucleotide-excision repair, DNA damage recognition TAS GO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS GO:0000724 double-strand break repair via homologous recombination TAS GO:0006273 lagging strand elongation IBA GO:0006281 DNA repair 17396150 TAS GO:0006293 nucleotide-excision repair, preincision complex stabilization TAS GO:0006294 nucleotide-excision repair, preincision complex assembly TAS GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion TAS GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion TAS GO:0006302 double-strand break repair 23230272 IMP GO:0006366 transcription from RNA polymerase II promoter 10944198 TAS GO:0006471 protein ADP-ribosylation 17396150 IDA GO:0006974 cellular response to DNA damage stimulus 24550317 IMP GO:0007005 mitochondrion organization 25378300 IMP GO:0007179 transforming growth factor beta receptor signaling pathway IEA GO:0010613 positive regulation of cardiac muscle hypertrophy ISS GO:0016540 protein autoprocessing IEA GO:0016925 protein sumoylation TAS GO:0023019 signal transduction involved in regulation of gene expression IEA GO:0030225 macrophage differentiation 18309324 TAS GO:0032042 mitochondrial DNA metabolic process 25378300 IMP GO:0032869 cellular response to insulin stimulus 19303849 IDA GO:0033683 nucleotide-excision repair, DNA incision TAS GO:0034599 cellular response to oxidative stress 25378300 IMP GO:0036211 protein modification process 25378300 IMP GO:0042769 DNA damage response, detection of DNA damage IEA GO:0043504 mitochondrial DNA repair 25378300 IMP GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0051103 DNA ligation involved in DNA repair IBA GO:0060391 positive regulation of SMAD protein import into nucleus IEA GO:0070212 protein poly-ADP-ribosylation 15674325 19470756 IDA GO:0070911 global genome nucleotide-excision repair TAS GO:1903827 regulation of cellular protein localization 24550317 IMP GO:1904357 negative regulation of telomere maintenance via telomere lengthening ISS GO:2000679 positive regulation of transcription regulatory region DNA binding IEA",IEA GO:0003677 DNA binding IBA GO:0003910 DNA ligase (ATP) activity IDA 16107709 17396150 19470756 23275542 NAD+ ADP-ribosyltransferase activity GO:0003950 TAS GO:0003950 NAD+ ADP-ribosyltransferase activity IPI 9518481 11248244 14596914 14627987 14734561 15044383 15555565 16490787 17396150 18172500 18971944 19661379 19779455 21266351 21549307 21575865 21577210 22863007 23230272 23481255 24778456 25640309 protein binding GO:0005515 IPI 19303849 transcription factor binding GO:0008134 IEA GO:0008270 zinc ion binding IPI 23382074 enzyme binding GO:0019899 IPI 17177976 protein kinase binding GO:0019901 IPI 14734561 23481255 identical protein binding GO:0042802 IEA GO:0042826 histone deacetylase binding IDA 22658674 22681889 poly(A) RNA binding GO:0044822 IPI 16107709 protein N-terminus binding GO:0047485 IEA GO:0051287 NAD binding IEA GO:0070412 R-SMAD binding,Base excision repair - Homo sapiens (human) hsa03410 NF-kappa B signaling pathway - Homo sapiens (human) hsa04064,chemicalprobes.org Veliparib,P09874,Poly [ADP-ribose] polymerase-1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,142,PARP1,POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 Signal Transduction R-HSA-162582 Signaling by TGF-beta Receptor Complex R-HSA-170834 Generic Transcription Pathway R-HSA-212436 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 SUMOylation R-HSA-2990846 SUMOylation of DNA damage response and repair proteins R-HSA-3108214 SUMO E3 ligases SUMOylate target proteins R-HSA-3108232 Metabolism of proteins R-HSA-392499 Post-translational protein modification R-HSA-597592 Base Excision Repair R-HSA-73884 DNA Repair R-HSA-73894 Resolution of Abasic Sites (AP sites) R-HSA-73933 Gene Expression R-HSA-74160,"19135898 GO:0000784 nuclear chromosome, telomeric region IDA 17177976 GO:0005634 nucleus IDA 9518481 GO:0005635 nuclear envelope IDA GO:0005654 nucleoplasm TAS 19303849 GO:0005667 transcription factor complex IDA 9518481 16107709 GO:0005730 nucleolus IDA 25378300 GO:0005739 mitochondrion IDA 19946888 GO:0016020 membrane IDA 25378300 GO:0043234 protein complex IDA","GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS GO:0000715 nucleotide-excision repair, DNA damage recognition TAS GO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS GO:0000724 double-strand break repair via homologous recombination TAS GO:0006273 lagging strand elongation IBA GO:0006281 DNA repair 17396150 TAS GO:0006293 nucleotide-excision repair, preincision complex stabilization TAS GO:0006294 nucleotide-excision repair, preincision complex assembly TAS GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion TAS GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion TAS GO:0006302 double-strand break repair 23230272 IMP GO:0006366 transcription from RNA polymerase II promoter 10944198 TAS GO:0006471 protein ADP-ribosylation 17396150 IDA GO:0006974 cellular response to DNA damage stimulus 24550317 IMP GO:0007005 mitochondrion organization 25378300 IMP GO:0007179 transforming growth factor beta receptor signaling pathway IEA GO:0010613 positive regulation of cardiac muscle hypertrophy ISS GO:0016540 protein autoprocessing IEA GO:0016925 protein sumoylation TAS GO:0023019 signal transduction involved in regulation of gene expression IEA GO:0030225 macrophage differentiation 18309324 TAS GO:0032042 mitochondrial DNA metabolic process 25378300 IMP GO:0032869 cellular response to insulin stimulus 19303849 IDA GO:0033683 nucleotide-excision repair, DNA incision TAS GO:0034599 cellular response to oxidative stress 25378300 IMP GO:0036211 protein modification process 25378300 IMP GO:0042769 DNA damage response, detection of DNA damage IEA GO:0043504 mitochondrial DNA repair 25378300 IMP GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0051103 DNA ligation involved in DNA repair IBA GO:0060391 positive regulation of SMAD protein import into nucleus IEA GO:0070212 protein poly-ADP-ribosylation 15674325 19470756 IDA GO:0070911 global genome nucleotide-excision repair TAS GO:1903827 regulation of cellular protein localization 24550317 IMP GO:1904357 negative regulation of telomere maintenance via telomere lengthening ISS GO:2000679 positive regulation of transcription regulatory region DNA binding IEA",IEA GO:0003677 DNA binding IBA GO:0003910 DNA ligase (ATP) activity IDA 16107709 17396150 19470756 23275542 NAD+ ADP-ribosyltransferase activity GO:0003950 TAS GO:0003950 NAD+ ADP-ribosyltransferase activity IPI 9518481 11248244 14596914 14627987 14734561 15044383 15555565 16490787 17396150 18172500 18971944 19661379 19779455 21266351 21549307 21575865 21577210 22863007 23230272 23481255 24778456 25640309 protein binding GO:0005515 IPI 19303849 transcription factor binding GO:0008134 IEA GO:0008270 zinc ion binding IPI 23382074 enzyme binding GO:0019899 IPI 17177976 protein kinase binding GO:0019901 IPI 14734561 23481255 identical protein binding GO:0042802 IEA GO:0042826 histone deacetylase binding IDA 22658674 22681889 poly(A) RNA binding GO:0044822 IPI 16107709 protein N-terminus binding GO:0047485 IEA GO:0051287 NAD binding IEA GO:0070412 R-SMAD binding,Base excision repair - Homo sapiens (human) hsa03410 NF-kappa B signaling pathway - Homo sapiens (human) hsa04064,chemicalprobes.org AZ0108,P09874,Poly [ADP-ribose] polymerase-1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,142,PARP1,POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 Signal Transduction R-HSA-162582 Signaling by TGF-beta Receptor Complex R-HSA-170834 Generic Transcription Pathway R-HSA-212436 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 SUMOylation R-HSA-2990846 SUMOylation of DNA damage response and repair proteins R-HSA-3108214 SUMO E3 ligases SUMOylate target proteins R-HSA-3108232 Metabolism of proteins R-HSA-392499 Post-translational protein modification R-HSA-597592 Base Excision Repair R-HSA-73884 DNA Repair R-HSA-73894 Resolution of Abasic Sites (AP sites) R-HSA-73933 Gene Expression R-HSA-74160,"19135898 GO:0000784 nuclear chromosome, telomeric region IDA 17177976 GO:0005634 nucleus IDA 9518481 GO:0005635 nuclear envelope IDA GO:0005654 nucleoplasm TAS 19303849 GO:0005667 transcription factor complex IDA 9518481 16107709 GO:0005730 nucleolus IDA 25378300 GO:0005739 mitochondrion IDA 19946888 GO:0016020 membrane IDA 25378300 GO:0043234 protein complex IDA","GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS GO:0000715 nucleotide-excision repair, DNA damage recognition TAS GO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS GO:0000724 double-strand break repair via homologous recombination TAS GO:0006273 lagging strand elongation IBA GO:0006281 DNA repair 17396150 TAS GO:0006293 nucleotide-excision repair, preincision complex stabilization TAS GO:0006294 nucleotide-excision repair, preincision complex assembly TAS GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion TAS GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion TAS GO:0006302 double-strand break repair 23230272 IMP GO:0006366 transcription from RNA polymerase II promoter 10944198 TAS GO:0006471 protein ADP-ribosylation 17396150 IDA GO:0006974 cellular response to DNA damage stimulus 24550317 IMP GO:0007005 mitochondrion organization 25378300 IMP GO:0007179 transforming growth factor beta receptor signaling pathway IEA GO:0010613 positive regulation of cardiac muscle hypertrophy ISS GO:0016540 protein autoprocessing IEA GO:0016925 protein sumoylation TAS GO:0023019 signal transduction involved in regulation of gene expression IEA GO:0030225 macrophage differentiation 18309324 TAS GO:0032042 mitochondrial DNA metabolic process 25378300 IMP GO:0032869 cellular response to insulin stimulus 19303849 IDA GO:0033683 nucleotide-excision repair, DNA incision TAS GO:0034599 cellular response to oxidative stress 25378300 IMP GO:0036211 protein modification process 25378300 IMP GO:0042769 DNA damage response, detection of DNA damage IEA GO:0043504 mitochondrial DNA repair 25378300 IMP GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0051103 DNA ligation involved in DNA repair IBA GO:0060391 positive regulation of SMAD protein import into nucleus IEA GO:0070212 protein poly-ADP-ribosylation 15674325 19470756 IDA GO:0070911 global genome nucleotide-excision repair TAS GO:1903827 regulation of cellular protein localization 24550317 IMP GO:1904357 negative regulation of telomere maintenance via telomere lengthening ISS GO:2000679 positive regulation of transcription regulatory region DNA binding IEA",IEA GO:0003677 DNA binding IBA GO:0003910 DNA ligase (ATP) activity IDA 16107709 17396150 19470756 23275542 NAD+ ADP-ribosyltransferase activity GO:0003950 TAS GO:0003950 NAD+ ADP-ribosyltransferase activity IPI 9518481 11248244 14596914 14627987 14734561 15044383 15555565 16490787 17396150 18172500 18971944 19661379 19779455 21266351 21549307 21575865 21577210 22863007 23230272 23481255 24778456 25640309 protein binding GO:0005515 IPI 19303849 transcription factor binding GO:0008134 IEA GO:0008270 zinc ion binding IPI 23382074 enzyme binding GO:0019899 IPI 17177976 protein kinase binding GO:0019901 IPI 14734561 23481255 identical protein binding GO:0042802 IEA GO:0042826 histone deacetylase binding IDA 22658674 22681889 poly(A) RNA binding GO:0044822 IPI 16107709 protein N-terminus binding GO:0047485 IEA GO:0051287 NAD binding IEA GO:0070412 R-SMAD binding,Base excision repair - Homo sapiens (human) hsa03410 NF-kappa B signaling pathway - Homo sapiens (human) hsa04064,chemicalprobes.org E7449,P09874,Poly [ADP-ribose] polymerase-1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,142,PARP1,POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 Signal Transduction R-HSA-162582 Signaling by TGF-beta Receptor Complex R-HSA-170834 Generic Transcription Pathway R-HSA-212436 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 SUMOylation R-HSA-2990846 SUMOylation of DNA damage response and repair proteins R-HSA-3108214 SUMO E3 ligases SUMOylate target proteins R-HSA-3108232 Metabolism of proteins R-HSA-392499 Post-translational protein modification R-HSA-597592 Base Excision Repair R-HSA-73884 DNA Repair R-HSA-73894 Resolution of Abasic Sites (AP sites) R-HSA-73933 Gene Expression R-HSA-74160,"19135898 GO:0000784 nuclear chromosome, telomeric region IDA 17177976 GO:0005634 nucleus IDA 9518481 GO:0005635 nuclear envelope IDA GO:0005654 nucleoplasm TAS 19303849 GO:0005667 transcription factor complex IDA 9518481 16107709 GO:0005730 nucleolus IDA 25378300 GO:0005739 mitochondrion IDA 19946888 GO:0016020 membrane IDA 25378300 GO:0043234 protein complex IDA","GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS GO:0000715 nucleotide-excision repair, DNA damage recognition TAS GO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS GO:0000724 double-strand break repair via homologous recombination TAS GO:0006273 lagging strand elongation IBA GO:0006281 DNA repair 17396150 TAS GO:0006293 nucleotide-excision repair, preincision complex stabilization TAS GO:0006294 nucleotide-excision repair, preincision complex assembly TAS GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion TAS GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion TAS GO:0006302 double-strand break repair 23230272 IMP GO:0006366 transcription from RNA polymerase II promoter 10944198 TAS GO:0006471 protein ADP-ribosylation 17396150 IDA GO:0006974 cellular response to DNA damage stimulus 24550317 IMP GO:0007005 mitochondrion organization 25378300 IMP GO:0007179 transforming growth factor beta receptor signaling pathway IEA GO:0010613 positive regulation of cardiac muscle hypertrophy ISS GO:0016540 protein autoprocessing IEA GO:0016925 protein sumoylation TAS GO:0023019 signal transduction involved in regulation of gene expression IEA GO:0030225 macrophage differentiation 18309324 TAS GO:0032042 mitochondrial DNA metabolic process 25378300 IMP GO:0032869 cellular response to insulin stimulus 19303849 IDA GO:0033683 nucleotide-excision repair, DNA incision TAS GO:0034599 cellular response to oxidative stress 25378300 IMP GO:0036211 protein modification process 25378300 IMP GO:0042769 DNA damage response, detection of DNA damage IEA GO:0043504 mitochondrial DNA repair 25378300 IMP GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0051103 DNA ligation involved in DNA repair IBA GO:0060391 positive regulation of SMAD protein import into nucleus IEA GO:0070212 protein poly-ADP-ribosylation 15674325 19470756 IDA GO:0070911 global genome nucleotide-excision repair TAS GO:1903827 regulation of cellular protein localization 24550317 IMP GO:1904357 negative regulation of telomere maintenance via telomere lengthening ISS GO:2000679 positive regulation of transcription regulatory region DNA binding IEA",IEA GO:0003677 DNA binding IBA GO:0003910 DNA ligase (ATP) activity IDA 16107709 17396150 19470756 23275542 NAD+ ADP-ribosyltransferase activity GO:0003950 TAS GO:0003950 NAD+ ADP-ribosyltransferase activity IPI 9518481 11248244 14596914 14627987 14734561 15044383 15555565 16490787 17396150 18172500 18971944 19661379 19779455 21266351 21549307 21575865 21577210 22863007 23230272 23481255 24778456 25640309 protein binding GO:0005515 IPI 19303849 transcription factor binding GO:0008134 IEA GO:0008270 zinc ion binding IPI 23382074 enzyme binding GO:0019899 IPI 17177976 protein kinase binding GO:0019901 IPI 14734561 23481255 identical protein binding GO:0042802 IEA GO:0042826 histone deacetylase binding IDA 22658674 22681889 poly(A) RNA binding GO:0044822 IPI 16107709 protein N-terminus binding GO:0047485 IEA GO:0051287 NAD binding IEA GO:0070412 R-SMAD binding,Base excision repair - Homo sapiens (human) hsa03410 NF-kappa B signaling pathway - Homo sapiens (human) hsa04064,chemicalprobes.org Talazoparib,P09874,Poly [ADP-ribose] polymerase-1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,142,PARP1,POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 Signal Transduction R-HSA-162582 Signaling by TGF-beta Receptor Complex R-HSA-170834 Generic Transcription Pathway R-HSA-212436 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 SUMOylation R-HSA-2990846 SUMOylation of DNA damage response and repair proteins R-HSA-3108214 SUMO E3 ligases SUMOylate target proteins R-HSA-3108232 Metabolism of proteins R-HSA-392499 Post-translational protein modification R-HSA-597592 Base Excision Repair R-HSA-73884 DNA Repair R-HSA-73894 Resolution of Abasic Sites (AP sites) R-HSA-73933 Gene Expression R-HSA-74160,"19135898 GO:0000784 nuclear chromosome, telomeric region IDA 17177976 GO:0005634 nucleus IDA 9518481 GO:0005635 nuclear envelope IDA GO:0005654 nucleoplasm TAS 19303849 GO:0005667 transcription factor complex IDA 9518481 16107709 GO:0005730 nucleolus IDA 25378300 GO:0005739 mitochondrion IDA 19946888 GO:0016020 membrane IDA 25378300 GO:0043234 protein complex IDA","GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS GO:0000715 nucleotide-excision repair, DNA damage recognition TAS GO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS GO:0000724 double-strand break repair via homologous recombination TAS GO:0006273 lagging strand elongation IBA GO:0006281 DNA repair 17396150 TAS GO:0006293 nucleotide-excision repair, preincision complex stabilization TAS GO:0006294 nucleotide-excision repair, preincision complex assembly TAS GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion TAS GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion TAS GO:0006302 double-strand break repair 23230272 IMP GO:0006366 transcription from RNA polymerase II promoter 10944198 TAS GO:0006471 protein ADP-ribosylation 17396150 IDA GO:0006974 cellular response to DNA damage stimulus 24550317 IMP GO:0007005 mitochondrion organization 25378300 IMP GO:0007179 transforming growth factor beta receptor signaling pathway IEA GO:0010613 positive regulation of cardiac muscle hypertrophy ISS GO:0016540 protein autoprocessing IEA GO:0016925 protein sumoylation TAS GO:0023019 signal transduction involved in regulation of gene expression IEA GO:0030225 macrophage differentiation 18309324 TAS GO:0032042 mitochondrial DNA metabolic process 25378300 IMP GO:0032869 cellular response to insulin stimulus 19303849 IDA GO:0033683 nucleotide-excision repair, DNA incision TAS GO:0034599 cellular response to oxidative stress 25378300 IMP GO:0036211 protein modification process 25378300 IMP GO:0042769 DNA damage response, detection of DNA damage IEA GO:0043504 mitochondrial DNA repair 25378300 IMP GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0051103 DNA ligation involved in DNA repair IBA GO:0060391 positive regulation of SMAD protein import into nucleus IEA GO:0070212 protein poly-ADP-ribosylation 15674325 19470756 IDA GO:0070911 global genome nucleotide-excision repair TAS GO:1903827 regulation of cellular protein localization 24550317 IMP GO:1904357 negative regulation of telomere maintenance via telomere lengthening ISS GO:2000679 positive regulation of transcription regulatory region DNA binding IEA",IEA GO:0003677 DNA binding IBA GO:0003910 DNA ligase (ATP) activity IDA 16107709 17396150 19470756 23275542 NAD+ ADP-ribosyltransferase activity GO:0003950 TAS GO:0003950 NAD+ ADP-ribosyltransferase activity IPI 9518481 11248244 14596914 14627987 14734561 15044383 15555565 16490787 17396150 18172500 18971944 19661379 19779455 21266351 21549307 21575865 21577210 22863007 23230272 23481255 24778456 25640309 protein binding GO:0005515 IPI 19303849 transcription factor binding GO:0008134 IEA GO:0008270 zinc ion binding IPI 23382074 enzyme binding GO:0019899 IPI 17177976 protein kinase binding GO:0019901 IPI 14734561 23481255 identical protein binding GO:0042802 IEA GO:0042826 histone deacetylase binding IDA 22658674 22681889 poly(A) RNA binding GO:0044822 IPI 16107709 protein N-terminus binding GO:0047485 IEA GO:0051287 NAD binding IEA GO:0070412 R-SMAD binding,Base excision repair - Homo sapiens (human) hsa03410 NF-kappa B signaling pathway - Homo sapiens (human) hsa04064,chemicalprobes.org Olaparib,Q9UGN5,Poly [ADP-ribose] polymerase 2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10038,PARP2,R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-73884 Base Excision Repair R-HSA-73894 DNA Repair R-HSA-73933 Resolution of Abasic Sites (AP sites),nucleus IDA GO:0005634 nucleoplasm IDA 15615785 GO:0005654 nucleolus IDA 15615785 GO:0005730 cytoplasm IBA GO:0005737,lagging strand elongation GO:0006273 IBA DNA repair GO:0006281 TAS 7260241 base-excision repair GO:0006284 IEA protein ADP-ribosylation GO:0006471 IEA DNA ligation involved in DNA repair GO:0051103 IBA extrinsic apoptotic signaling pathway GO:0097191 IEA,IEA GO:0003677 DNA binding IBA GO:0003910 DNA ligase (ATP) activity IEA GO:0003950 NAD+ ADP-ribosyltransferase activity 21812934 IPI GO:0005515 protein binding,hsa03410 Base excision repair - Homo sapiens (human),chemicalprobes.org MK-4827,Q9UGN5,Poly [ADP-ribose] polymerase 2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10038,PARP2,R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-73884 Base Excision Repair R-HSA-73894 DNA Repair R-HSA-73933 Resolution of Abasic Sites (AP sites),nucleus IDA GO:0005634 nucleoplasm IDA 15615785 GO:0005654 nucleolus IDA 15615785 GO:0005730 cytoplasm IBA GO:0005737,lagging strand elongation GO:0006273 IBA DNA repair GO:0006281 TAS 7260241 base-excision repair GO:0006284 IEA protein ADP-ribosylation GO:0006471 IEA DNA ligation involved in DNA repair GO:0051103 IBA extrinsic apoptotic signaling pathway GO:0097191 IEA,IEA GO:0003677 DNA binding IBA GO:0003910 DNA ligase (ATP) activity IEA GO:0003950 NAD+ ADP-ribosyltransferase activity 21812934 IPI GO:0005515 protein binding,hsa03410 Base excision repair - Homo sapiens (human),chemicalprobes.org Veliparib,Q9UGN5,Poly [ADP-ribose] polymerase 2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10038,PARP2,R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-73884 Base Excision Repair R-HSA-73894 DNA Repair R-HSA-73933 Resolution of Abasic Sites (AP sites),nucleus IDA GO:0005634 nucleoplasm IDA 15615785 GO:0005654 nucleolus IDA 15615785 GO:0005730 cytoplasm IBA GO:0005737,lagging strand elongation GO:0006273 IBA DNA repair GO:0006281 TAS 7260241 base-excision repair GO:0006284 IEA protein ADP-ribosylation GO:0006471 IEA DNA ligation involved in DNA repair GO:0051103 IBA extrinsic apoptotic signaling pathway GO:0097191 IEA,IEA GO:0003677 DNA binding IBA GO:0003910 DNA ligase (ATP) activity IEA GO:0003950 NAD+ ADP-ribosyltransferase activity 21812934 IPI GO:0005515 protein binding,hsa03410 Base excision repair - Homo sapiens (human),chemicalprobes.org AZ0108,Q9UGN5,Poly [ADP-ribose] polymerase 2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10038,PARP2,R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-73884 Base Excision Repair R-HSA-73894 DNA Repair R-HSA-73933 Resolution of Abasic Sites (AP sites),nucleus IDA GO:0005634 nucleoplasm IDA 15615785 GO:0005654 nucleolus IDA 15615785 GO:0005730 cytoplasm IBA GO:0005737,lagging strand elongation GO:0006273 IBA DNA repair GO:0006281 TAS 7260241 base-excision repair GO:0006284 IEA protein ADP-ribosylation GO:0006471 IEA DNA ligation involved in DNA repair GO:0051103 IBA extrinsic apoptotic signaling pathway GO:0097191 IEA,IEA GO:0003677 DNA binding IBA GO:0003910 DNA ligase (ATP) activity IEA GO:0003950 NAD+ ADP-ribosyltransferase activity 21812934 IPI GO:0005515 protein binding,hsa03410 Base excision repair - Homo sapiens (human),chemicalprobes.org E7449,Q9UGN5,Poly [ADP-ribose] polymerase 2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10038,PARP2,R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-73884 Base Excision Repair R-HSA-73894 DNA Repair R-HSA-73933 Resolution of Abasic Sites (AP sites),nucleus IDA GO:0005634 nucleoplasm IDA 15615785 GO:0005654 nucleolus IDA 15615785 GO:0005730 cytoplasm IBA GO:0005737,lagging strand elongation GO:0006273 IBA DNA repair GO:0006281 TAS 7260241 base-excision repair GO:0006284 IEA protein ADP-ribosylation GO:0006471 IEA DNA ligation involved in DNA repair GO:0051103 IBA extrinsic apoptotic signaling pathway GO:0097191 IEA,IEA GO:0003677 DNA binding IBA GO:0003910 DNA ligase (ATP) activity IEA GO:0003950 NAD+ ADP-ribosyltransferase activity 21812934 IPI GO:0005515 protein binding,hsa03410 Base excision repair - Homo sapiens (human),chemicalprobes.org Talazoparib,Q9UGN5,Poly [ADP-ribose] polymerase 2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10038,PARP2,R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-73884 Base Excision Repair R-HSA-73894 DNA Repair R-HSA-73933 Resolution of Abasic Sites (AP sites),nucleus IDA GO:0005634 nucleoplasm IDA 15615785 GO:0005654 nucleolus IDA 15615785 GO:0005730 cytoplasm IBA GO:0005737,lagging strand elongation GO:0006273 IBA DNA repair GO:0006281 TAS 7260241 base-excision repair GO:0006284 IEA protein ADP-ribosylation GO:0006471 IEA DNA ligation involved in DNA repair GO:0051103 IBA extrinsic apoptotic signaling pathway GO:0097191 IEA,IEA GO:0003677 DNA binding IBA GO:0003910 DNA ligase (ATP) activity IEA GO:0003950 NAD+ ADP-ribosyltransferase activity 21812934 IPI GO:0005515 protein binding,hsa03410 Base excision repair - Homo sapiens (human),chemicalprobes.org AZ0108,Q2NL67,Poly [ADP-ribose] polymerase 6,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,56965,PARP6,,,,NAD+ ADP-ribosyltransferase activity GO:0003950 IEA,,chemicalprobes.org GSK484,Q9UM07,Protein-arginine deiminase type-4,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,23569,PADI4,,GO:0005634 nucleus 15339660 IDA GO:0005654 nucleoplasm TAS GO:0005829 cytosol TAS,"TAS GO:0006325 chromatin organization ISS GO:0006334 nucleosome assembly ISS GO:0006338 chromatin remodeling IEA GO:0006351 transcription, DNA-templated IEA GO:0006355 regulation of transcription, DNA-templated TAS 10488123 cellular protein modification process GO:0006464 ISS GO:0016568 chromatin modification IDA 21584310 protein citrullination GO:0018101 ISS GO:0019827 stem cell population maintenance IDA 15339660 16567635 histone H3-R26 citrullination GO:0036413 IDA 15339660 16567635 histone citrullination GO:0036414 IEA GO:0045087 innate immune response",protein-arginine deiminase activity GO:0004668 15339660 16567635 IDA protein-arginine deiminase activity GO:0004668 TAS calcium ion binding GO:0005509 16567635 IDA protein binding GO:0005515 21584310 25416956 IPI arginine deiminase activity GO:0016990 21584310 IDA,,chemicalprobes.org MS023,Q99873,Protein-arginine N-methyltransferase 1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,3276,ANM1,RMTs methylate histone arginines R-HSA-3214858 Chromatin modifying enzymes R-HSA-3247509 Chromatin organization R-HSA-4839726,10749851 GO:0005634 nucleus IDA GO:0005654 nucleoplasm TAS 9029147 GO:0005737 cytoplasm TAS GO:0005829 cytosol IBA 25284789 GO:0034709 methylosome IDA,"GO:0006355 regulation of transcription, DNA-templated IBA GO:0006479 protein methylation 9545638 TAS GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS GO:0007166 cell surface receptor signaling pathway 9029147 TAS GO:0016571 histone methylation 19405910 IDA GO:0018216 peptidyl-arginine methylation 18657504 19460357 IDA GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IEA GO:0031175 neuron projection development 18773938 IMP GO:0043985 histone H4-R3 methylation 11448779 IDA GO:0045648 positive regulation of erythrocyte differentiation 23483889 IMP GO:0045653 negative regulation of megakaryocyte differentiation 20442406 IDA GO:0046985 positive regulation of hemoglobin biosynthetic process ISS GO:1900745 positive regulation of p38MAPK cascade ISS",IPI 8663146 10749851 15084609 16051612 16169070 17053781 19101556 19124016 19858291 22190034 23455924 23912080 25284789 25416956 protein binding GO:0005515 TAS 9545638 methyltransferase activity GO:0008168 IDA 18657504 N-methyltransferase activity GO:0008170 IMP 19124016 N-methyltransferase activity GO:0008170 IDA 19460357 protein methyltransferase activity GO:0008276 IDA 25284789 methyl-CpG binding GO:0008327 IDA 18495660 protein-arginine N-methyltransferase activity GO:0016274 TAS GO:0016274 protein-arginine N-methyltransferase activity IPI 19460357 enzyme binding GO:0019899 IMP 25284789 protein-arginine omega-N asymmetric methyltransferase activity GO:0035242 IDA 19405910 histone methyltransferase activity GO:0042054 IPI 16169070 23455924 25416956 identical protein binding GO:0042802 IDA 11448779 histone methyltransferase activity (H4-R3 specific) GO:0044020 IMP 25284789 histone methyltransferase activity (H4-R3 specific) GO:0044020 IDA 22681889 poly(A) RNA binding GO:0044822 IPI 23483889 mitogen-activated protein kinase p38 binding GO:0048273,FoxO signaling pathway - Homo sapiens (human) hsa04068 Glucagon signaling pathway - Homo sapiens (human) hsa04922,chemicalprobes.org SGC707,O60678,Protein arginine N-methyltransferase 3,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10196,ANM3,,9642256 GO:0005737 cytoplasm NAS GO:0005829 cytosol IBA GO:0005840 ribosome IEA,"GO:0006355 regulation of transcription, DNA-templated IBA GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IEA GO:0031397 negative regulation of protein ubiquitination 18573314 IDA GO:0034969 histone arginine methylation IEA",IPI 18573314 23912080 protein binding GO:0005515 IDA 18573314 methyltransferase activity GO:0008168 IBA GO:0008469 histone-arginine N-methyltransferase activity NAS 9642256 protein-arginine N-methyltransferase activity GO:0016274 IBA GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity IEA GO:0046872 metal ion binding,,chemicalprobes.org MS023,O60678,Protein arginine N-methyltransferase 3,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10196,ANM3,,9642256 GO:0005737 cytoplasm NAS GO:0005829 cytosol IBA GO:0005840 ribosome IEA,"GO:0006355 regulation of transcription, DNA-templated IBA GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IEA GO:0031397 negative regulation of protein ubiquitination 18573314 IDA GO:0034969 histone arginine methylation IEA",IPI 18573314 23912080 protein binding GO:0005515 IDA 18573314 methyltransferase activity GO:0008168 IBA GO:0008469 histone-arginine N-methyltransferase activity NAS 9642256 protein-arginine N-methyltransferase activity GO:0016274 IBA GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity IEA GO:0046872 metal ion binding,,chemicalprobes.org MS023,O14744,Protein arginine N-methyltransferase 5,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10419,ANM5,R-HSA-191859 snRNP Assembly R-HSA-194441 Metabolism of non-coding RNA R-HSA-3214858 RMTs methylate histone arginines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization R-HSA-74160 Gene Expression,GO:0005634 nucleus IDA GO:0005634 nucleus 18404153 NAS GO:0005654 nucleoplasm TAS GO:0005737 cytoplasm 22952863 IDA GO:0005794 Golgi apparatus 20421892 IDA GO:0005829 cytosol 18984161 IDA GO:0005829 cytosol TAS GO:0034709 methylosome 18984161 25284789 IDA GO:0035097 histone methyltransferase complex 23048031 IDA,"IMP 17709427 spliceosomal snRNP assembly GO:0000387 TAS GO:0000387 spliceosomal snRNP assembly IMP 26700805 DNA-templated transcription, termination GO:0006353 IBA GO:0006355 regulation of transcription, DNA-templated TAS 9843966 regulation of mitotic nuclear division GO:0007088 TAS 9843966 cell proliferation GO:0008283 IMP 17709427 peptidyl-arginine methylation GO:0018216 IEA GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine ISS GO:0032922 circadian regulation of gene expression IDA 15369763 26554819 peptidyl-arginine N-methylation GO:0035246 IMP 22269951 endothelial cell activation GO:0042118 ISS GO:0043985 histone H4-R3 methylation NAS 18404153 histone H4-R3 methylation GO:0043985 IEA GO:0044030 regulation of DNA methylation IEA GO:0045596 negative regulation of cell differentiation IEA GO:0048714 positive regulation of oligodendrocyte differentiation IEA GO:0070372 regulation of ERK1 and ERK2 cascade IMP 20421892 Golgi ribbon formation GO:0090161 IEA GO:0097421 liver regeneration TAS GO:1901796 regulation of signal transduction by p53 class mediator IEA GO:1903507 negative regulation of nucleic acid-templated transcription IGI 26554819 positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:1904992",core promoter sequence-specific DNA binding GO:0001046 ISS transcription corepressor activity GO:0003714 ISS protein binding GO:0005515 16087681 18404153 18984161 20159986 20421892 20810653 20951943 22269951 22327218 22365833 23455924 23892143 25284789 25852190 26700805 IPI methyltransferase activity GO:0008168 15369763 IDA methyl-CpG binding GO:0008327 25284789 IDA histone-arginine N-methyltransferase activity GO:0008469 TAS protein-arginine N-methyltransferase activity GO:0016274 20421892 26554819 IDA protein-arginine N-methyltransferase activity GO:0016274 TAS protein complex binding GO:0032403 IEA protein-arginine omega-N symmetric methyltransferase activity GO:0035243 19011621 EXP protein-arginine omega-N symmetric methyltransferase activity GO:0035243 17709427 IMP ribonucleoprotein complex binding GO:0043021 17709427 IPI histone methyltransferase activity (H4-R3 specific) GO:0044020 25284789 IMP protein heterodimerization activity GO:0046982 18495660 IDA,RNA transport - Homo sapiens (human) hsa03013,chemicalprobes.org EPZ015666,O14744,Protein arginine N-methyltransferase 5,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10419,ANM5,R-HSA-191859 snRNP Assembly R-HSA-194441 Metabolism of non-coding RNA R-HSA-3214858 RMTs methylate histone arginines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization R-HSA-74160 Gene Expression,GO:0005634 nucleus IDA GO:0005634 nucleus 18404153 NAS GO:0005654 nucleoplasm TAS GO:0005737 cytoplasm 22952863 IDA GO:0005794 Golgi apparatus 20421892 IDA GO:0005829 cytosol 18984161 IDA GO:0005829 cytosol TAS GO:0034709 methylosome 18984161 25284789 IDA GO:0035097 histone methyltransferase complex 23048031 IDA,"IMP 17709427 spliceosomal snRNP assembly GO:0000387 TAS GO:0000387 spliceosomal snRNP assembly IMP 26700805 DNA-templated transcription, termination GO:0006353 IBA GO:0006355 regulation of transcription, DNA-templated TAS 9843966 regulation of mitotic nuclear division GO:0007088 TAS 9843966 cell proliferation GO:0008283 IMP 17709427 peptidyl-arginine methylation GO:0018216 IEA GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine ISS GO:0032922 circadian regulation of gene expression IDA 15369763 26554819 peptidyl-arginine N-methylation GO:0035246 IMP 22269951 endothelial cell activation GO:0042118 ISS GO:0043985 histone H4-R3 methylation NAS 18404153 histone H4-R3 methylation GO:0043985 IEA GO:0044030 regulation of DNA methylation IEA GO:0045596 negative regulation of cell differentiation IEA GO:0048714 positive regulation of oligodendrocyte differentiation IEA GO:0070372 regulation of ERK1 and ERK2 cascade IMP 20421892 Golgi ribbon formation GO:0090161 IEA GO:0097421 liver regeneration TAS GO:1901796 regulation of signal transduction by p53 class mediator IEA GO:1903507 negative regulation of nucleic acid-templated transcription IGI 26554819 positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:1904992",core promoter sequence-specific DNA binding GO:0001046 ISS transcription corepressor activity GO:0003714 ISS protein binding GO:0005515 16087681 18404153 18984161 20159986 20421892 20810653 20951943 22269951 22327218 22365833 23455924 23892143 25284789 25852190 26700805 IPI methyltransferase activity GO:0008168 15369763 IDA methyl-CpG binding GO:0008327 25284789 IDA histone-arginine N-methyltransferase activity GO:0008469 TAS protein-arginine N-methyltransferase activity GO:0016274 20421892 26554819 IDA protein-arginine N-methyltransferase activity GO:0016274 TAS protein complex binding GO:0032403 IEA protein-arginine omega-N symmetric methyltransferase activity GO:0035243 19011621 EXP protein-arginine omega-N symmetric methyltransferase activity GO:0035243 17709427 IMP ribonucleoprotein complex binding GO:0043021 17709427 IPI histone methyltransferase activity (H4-R3 specific) GO:0044020 25284789 IMP protein heterodimerization activity GO:0046982 18495660 IDA,RNA transport - Homo sapiens (human) hsa03013,chemicalprobes.org GSK591,O14744,Protein arginine N-methyltransferase 5,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10419,ANM5,R-HSA-191859 snRNP Assembly R-HSA-194441 Metabolism of non-coding RNA R-HSA-3214858 RMTs methylate histone arginines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization R-HSA-74160 Gene Expression,GO:0005634 nucleus IDA GO:0005634 nucleus 18404153 NAS GO:0005654 nucleoplasm TAS GO:0005737 cytoplasm 22952863 IDA GO:0005794 Golgi apparatus 20421892 IDA GO:0005829 cytosol 18984161 IDA GO:0005829 cytosol TAS GO:0034709 methylosome 18984161 25284789 IDA GO:0035097 histone methyltransferase complex 23048031 IDA,"IMP 17709427 spliceosomal snRNP assembly GO:0000387 TAS GO:0000387 spliceosomal snRNP assembly IMP 26700805 DNA-templated transcription, termination GO:0006353 IBA GO:0006355 regulation of transcription, DNA-templated TAS 9843966 regulation of mitotic nuclear division GO:0007088 TAS 9843966 cell proliferation GO:0008283 IMP 17709427 peptidyl-arginine methylation GO:0018216 IEA GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine ISS GO:0032922 circadian regulation of gene expression IDA 15369763 26554819 peptidyl-arginine N-methylation GO:0035246 IMP 22269951 endothelial cell activation GO:0042118 ISS GO:0043985 histone H4-R3 methylation NAS 18404153 histone H4-R3 methylation GO:0043985 IEA GO:0044030 regulation of DNA methylation IEA GO:0045596 negative regulation of cell differentiation IEA GO:0048714 positive regulation of oligodendrocyte differentiation IEA GO:0070372 regulation of ERK1 and ERK2 cascade IMP 20421892 Golgi ribbon formation GO:0090161 IEA GO:0097421 liver regeneration TAS GO:1901796 regulation of signal transduction by p53 class mediator IEA GO:1903507 negative regulation of nucleic acid-templated transcription IGI 26554819 positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:1904992",core promoter sequence-specific DNA binding GO:0001046 ISS transcription corepressor activity GO:0003714 ISS protein binding GO:0005515 16087681 18404153 18984161 20159986 20421892 20810653 20951943 22269951 22327218 22365833 23455924 23892143 25284789 25852190 26700805 IPI methyltransferase activity GO:0008168 15369763 IDA methyl-CpG binding GO:0008327 25284789 IDA histone-arginine N-methyltransferase activity GO:0008469 TAS protein-arginine N-methyltransferase activity GO:0016274 20421892 26554819 IDA protein-arginine N-methyltransferase activity GO:0016274 TAS protein complex binding GO:0032403 IEA protein-arginine omega-N symmetric methyltransferase activity GO:0035243 19011621 EXP protein-arginine omega-N symmetric methyltransferase activity GO:0035243 17709427 IMP ribonucleoprotein complex binding GO:0043021 17709427 IPI histone methyltransferase activity (H4-R3 specific) GO:0044020 25284789 IMP protein heterodimerization activity GO:0046982 18495660 IDA,RNA transport - Homo sapiens (human) hsa03013,chemicalprobes.org DS-437,O14744,Protein arginine N-methyltransferase 5,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10419,ANM5,R-HSA-191859 snRNP Assembly R-HSA-194441 Metabolism of non-coding RNA R-HSA-3214858 RMTs methylate histone arginines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization R-HSA-74160 Gene Expression,GO:0005634 nucleus IDA GO:0005634 nucleus 18404153 NAS GO:0005654 nucleoplasm TAS GO:0005737 cytoplasm 22952863 IDA GO:0005794 Golgi apparatus 20421892 IDA GO:0005829 cytosol 18984161 IDA GO:0005829 cytosol TAS GO:0034709 methylosome 18984161 25284789 IDA GO:0035097 histone methyltransferase complex 23048031 IDA,"IMP 17709427 spliceosomal snRNP assembly GO:0000387 TAS GO:0000387 spliceosomal snRNP assembly IMP 26700805 DNA-templated transcription, termination GO:0006353 IBA GO:0006355 regulation of transcription, DNA-templated TAS 9843966 regulation of mitotic nuclear division GO:0007088 TAS 9843966 cell proliferation GO:0008283 IMP 17709427 peptidyl-arginine methylation GO:0018216 IEA GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine ISS GO:0032922 circadian regulation of gene expression IDA 15369763 26554819 peptidyl-arginine N-methylation GO:0035246 IMP 22269951 endothelial cell activation GO:0042118 ISS GO:0043985 histone H4-R3 methylation NAS 18404153 histone H4-R3 methylation GO:0043985 IEA GO:0044030 regulation of DNA methylation IEA GO:0045596 negative regulation of cell differentiation IEA GO:0048714 positive regulation of oligodendrocyte differentiation IEA GO:0070372 regulation of ERK1 and ERK2 cascade IMP 20421892 Golgi ribbon formation GO:0090161 IEA GO:0097421 liver regeneration TAS GO:1901796 regulation of signal transduction by p53 class mediator IEA GO:1903507 negative regulation of nucleic acid-templated transcription IGI 26554819 positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:1904992",core promoter sequence-specific DNA binding GO:0001046 ISS transcription corepressor activity GO:0003714 ISS protein binding GO:0005515 16087681 18404153 18984161 20159986 20421892 20810653 20951943 22269951 22327218 22365833 23455924 23892143 25284789 25852190 26700805 IPI methyltransferase activity GO:0008168 15369763 IDA methyl-CpG binding GO:0008327 25284789 IDA histone-arginine N-methyltransferase activity GO:0008469 TAS protein-arginine N-methyltransferase activity GO:0016274 20421892 26554819 IDA protein-arginine N-methyltransferase activity GO:0016274 TAS protein complex binding GO:0032403 IEA protein-arginine omega-N symmetric methyltransferase activity GO:0035243 19011621 EXP protein-arginine omega-N symmetric methyltransferase activity GO:0035243 17709427 IMP ribonucleoprotein complex binding GO:0043021 17709427 IPI histone methyltransferase activity (H4-R3 specific) GO:0044020 25284789 IMP protein heterodimerization activity GO:0046982 18495660 IDA,RNA transport - Homo sapiens (human) hsa03013,chemicalprobes.org MS023,Q96LA8,Protein arginine N-methyltransferase 6,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,55170,ANM6,RMTs methylate histone arginines R-HSA-3214858 Chromatin modifying enzymes R-HSA-3247509 Chromatin organization R-HSA-4839726,nucleus GO:0005634 IDA 11724789 nucleoplasm GO:0005654 TAS cytosol GO:0005829 IBA,"IEA GO:0000122 negative regulation of transcription from RNA polymerase II promoter 16600869 TAS GO:0006284 base-excision repair IEA GO:0006351 transcription, DNA-templated IEA GO:0016032 viral process IEA GO:0016049 cell growth 19405910 IDA GO:0016571 histone methylation 17898714 18079182 IDA GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine 17898714 18079182 IDA GO:0034970 histone H3-R2 methylation IEA GO:0043985 histone H4-R3 methylation 18079182 IDA GO:0045892 negative regulation of transcription, DNA-templated IEA GO:0090398 cellular senescence",chromatin binding GO:0003682 IEA protein binding 16157300 16293633 16600869 23455924 25416956 GO:0005515 IPI histone-arginine N-methyltransferase activity 23980157 GO:0008469 IDA protein-arginine N-methyltransferase activity GO:0016274 TAS protein-arginine omega-N monomethyltransferase activity 11724789 16157300 16600869 GO:0035241 IDA protein-arginine omega-N asymmetric methyltransferase activity 11724789 16157300 17898714 18079182 GO:0035242 IDA histone methyltransferase activity 19405910 GO:0042054 IDA histone binding 17898714 18079182 GO:0042393 IDA histone methyltransferase activity (H4-R3 specific) 18079182 GO:0044020 IDA histone methyltransferase activity (H3-R2 specific) 17898714 18079182 GO:0070611 IDA histone methyltransferase activity (H2A-R3 specific) 18079182 GO:0070612 IDA,,chemicalprobes.org EPZ020411,Q96LA8,Protein arginine N-methyltransferase 6,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,55170,ANM6,RMTs methylate histone arginines R-HSA-3214858 Chromatin modifying enzymes R-HSA-3247509 Chromatin organization R-HSA-4839726,nucleus GO:0005634 IDA 11724789 nucleoplasm GO:0005654 TAS cytosol GO:0005829 IBA,"IEA GO:0000122 negative regulation of transcription from RNA polymerase II promoter 16600869 TAS GO:0006284 base-excision repair IEA GO:0006351 transcription, DNA-templated IEA GO:0016032 viral process IEA GO:0016049 cell growth 19405910 IDA GO:0016571 histone methylation 17898714 18079182 IDA GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine 17898714 18079182 IDA GO:0034970 histone H3-R2 methylation IEA GO:0043985 histone H4-R3 methylation 18079182 IDA GO:0045892 negative regulation of transcription, DNA-templated IEA GO:0090398 cellular senescence",chromatin binding GO:0003682 IEA protein binding 16157300 16293633 16600869 23455924 25416956 GO:0005515 IPI histone-arginine N-methyltransferase activity 23980157 GO:0008469 IDA protein-arginine N-methyltransferase activity GO:0016274 TAS protein-arginine omega-N monomethyltransferase activity 11724789 16157300 16600869 GO:0035241 IDA protein-arginine omega-N asymmetric methyltransferase activity 11724789 16157300 17898714 18079182 GO:0035242 IDA histone methyltransferase activity 19405910 GO:0042054 IDA histone binding 17898714 18079182 GO:0042393 IDA histone methyltransferase activity (H4-R3 specific) 18079182 GO:0044020 IDA histone methyltransferase activity (H3-R2 specific) 17898714 18079182 GO:0070611 IDA histone methyltransferase activity (H2A-R3 specific) 18079182 GO:0070612 IDA,,chemicalprobes.org GSK2334470,Q15118,Pyruvate dehydrogenase kinase isoform 1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,5163,PDK1,R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1430728 Metabolism R-HSA-162582 Signal Transduction R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-5362517 Signaling by Retinoic Acid R-HSA-70268 Pyruvate metabolism R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle,GO:0005739 mitochondrion 7499431 TAS GO:0005759 mitochondrial matrix TAS GO:0005967 mitochondrial pyruvate dehydrogenase complex IEA,IEA GO:0006006 glucose metabolic process IEA GO:0006468 protein phosphorylation IMP 18541534 cell proliferation GO:0008283 IMP 18541534 intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 TAS GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate IMP 18541534 regulation of glucose metabolic process GO:0010906 IMP 21763680 hypoxia-inducible factor-1alpha signaling pathway GO:0097411 IGI 22020285 mitophagy in response to mitochondrial depolarization GO:0098779,protein kinase activity GO:0004672 17683942 IDA pyruvate dehydrogenase (acetyl-transferring) kinase activity GO:0004740 11485553 EXP pyruvate dehydrogenase (acetyl-transferring) kinase activity GO:0004740 7499431 IDA pyruvate dehydrogenase (acetyl-transferring) kinase activity GO:0004740 22195962 IMP protein binding GO:0005515 17110931 IPI ATP binding GO:0005524 IEA,HIF-1 signaling pathway - Homo sapiens (human) hsa04066 Central carbon metabolism in cancer - Homo sapiens (human) hsa05230,chemicalprobes.org CP-724714,P04626,Receptor protein-tyrosine kinase erbB-2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2064,ERBB2,"R-HSA-112399 IRS-mediated signalling R-HSA-112412 SOS-mediated signalling R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250196 SHC1 events in ERBB2 signaling R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1250347 SHC1 events in ERBB4 signaling R-HSA-1251932 PLCG1 events in ERBB2 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1266738 Developmental Biology R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-1306955 GRB7 events in ERBB2 signaling R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling R-HSA-1433557 Signaling by SCF-KIT R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-166520 Signalling by NGF R-HSA-167044 Signalling to RAS R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-169893 Prolonged ERK activation events R-HSA-170968 Frs2-mediated activation R-HSA-170984 ARMS-mediated activation R-HSA-177929 Signaling by EGFR R-HSA-179812 GRB2 events in EGFR signaling R-HSA-180292 GAB1 signalosome R-HSA-180336 SHC1 events in EGFR signaling R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-187687 Signalling to ERKs R-HSA-187706 Signalling to p38 via RIT and RIN R-HSA-190236 Signaling by FGFR R-HSA-194138 Signaling by VEGF R-HSA-1963640 GRB2 events in ERBB2 signaling R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2586552 Signaling by Leptin R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-372790 Signaling by GPCR R-HSA-373755 Semaphorin interactions R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-400685 Sema4D in semaphorin signaling R-HSA-416572 Sema4D induced cell migration and growth-cone collapse R-HSA-422475 Axon guidance R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5663202 Diseases of signal transduction R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5683057 MAPK family signaling cascades R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-912526 Interleukin receptor SHC signaling R-HSA-983705 Signaling by the B Cell Receptor (BCR)",IDA 16314522 21555369 nucleus GO:0005634 IDA GO:0005737 cytoplasm IDA 20010870 plasma membrane GO:0005886 NAS 12000754 plasma membrane GO:0005886 TAS GO:0005886 plasma membrane IDA 16314522 endosome membrane GO:0010008 NAS 15609325 integral component of membrane GO:0016021 IDA 12646923 basolateral plasma membrane GO:0016323 IEA GO:0016324 apical plasma membrane IEA GO:0031410 cytoplasmic vesicle IEA GO:0043209 myelin sheath IDA 7514177 23382219 receptor complex GO:0043235 TAS 7556068 receptor complex GO:0043235 IEA GO:0048471 perinuclear region of cytoplasm,"MAPK cascade GO:0000165 TAS positive regulation of protein phosphorylation GO:0001934 ISS transcription, DNA-templated GO:0006351 IEA protein phosphorylation GO:0006468 10851066 TAS signal transduction GO:0007165 10572067 IDA cell surface receptor signaling pathway GO:0007166 9685399 IDA enzyme linked receptor protein signaling pathway GO:0007167 9590694 TAS transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 7514177 IDA transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 7556068 TAS peripheral nervous system development GO:0007422 IEA heart development GO:0007507 IEA neuromuscular junction development GO:0007528 IEA motor neuron axon guidance GO:0008045 IEA cell proliferation GO:0008283 10851066 TAS phosphatidylinositol 3-kinase signaling GO:0014065 7556068 IDA regulation of phosphatidylinositol 3-kinase signaling GO:0014066 TAS peptidyl-tyrosine phosphorylation GO:0018108 IEA positive regulation of cell growth GO:0030307 21555369 IMP regulation of microtubule-based process GO:0032886 20937854 IDA negative regulation of immature T cell proliferation in thymus GO:0033088 IEA ERBB2 signaling pathway GO:0038128 TAS wound healing GO:0042060 12646923 IDA myelination GO:0042552 IEA positive regulation of MAP kinase activity GO:0043406 10572067 IDA positive regulation of GTPase activity GO:0043547 ISS positive regulation of translation GO:0045727 21555369 IMP regulation of angiogenesis GO:0045765 15609325 NAS positive regulation of cell adhesion GO:0045785 7556068 IDA positive regulation of transcription from RNA polymerase I promoter GO:0045943 21555369 IMP positive regulation of transcription from RNA polymerase III promoter GO:0045945 19372587 IDA protein autophosphorylation GO:0046777 7556068 IDA phosphatidylinositol phosphorylation GO:0046854 IEA phosphatidylinositol-mediated signaling GO:0048015 TAS oligodendrocyte differentiation GO:0048709 IEA positive regulation of epithelial cell proliferation GO:0050679 10572067 IDA regulation of ERK1 and ERK2 cascade GO:0070372 16314522 IMP cellular response to growth factor stimulus GO:0071363 20010870 IDA positive regulation of protein targeting to membrane GO:0090314 20010870 IDA regulation of cell motility GO:2000145 TAS","21555369 GO:0001042 RNA polymerase I core binding IDA 7556068 GO:0004713 protein tyrosine kinase activity IDA 7556068 GO:0004713 protein tyrosine kinase activity IGI GO:0004713 protein tyrosine kinase activity TAS 7514177 GO:0004714 transmembrane receptor protein tyrosine kinase activity IDA GO:0004716 receptor signaling protein tyrosine kinase activity IEA 7514177 GO:0004888 transmembrane signaling receptor activity IDA GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS 7592681 9079677 10572067 10805725 11940572 12061724 12122014 12975581 15657067 16273093 16314522 16516204 16767099 16843263 17426253 19167335 19372587 19411071 19650109 20010870 20227043 20558745 20700126 20876300 21034468 21075308 21255571 21278786 21376233 21555369 21724847 21840311 22279592 22589551 22806884 22939624 23436906 23680147 23688700 23866081 24189400 24412244 24557338 24658140 24815698 25036637 25241761 25640309 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA 15520177 GO:0008022 protein C-terminus binding IPI 7514177 GO:0019838 growth factor binding IDA contributes_to 15899872 GO:0019903 protein phosphatase binding IPI 16843263 19650109 21255571 21480528 23436906 GO:0042802 identical protein binding IPI 9590694 GO:0043125 ErbB-3 class receptor binding TAS GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS 10572067 GO:0046982 protein heterodimerization activity IDA 7556068 GO:0046982 protein heterodimerization activity IPI 12000754 GO:0046983 protein dimerization activity NAS",hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04520 Adherens junction - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05212 Pancreatic cancer - Homo sapiens (human) hsa05213 Endometrial cancer - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05219 Bladder cancer - Homo sapiens (human) hsa05223 Non-small cell lung cancer - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human),chemicalprobes.org Afatinib,P04626,Receptor protein-tyrosine kinase erbB-2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2064,ERBB2,"R-HSA-112399 IRS-mediated signalling R-HSA-112412 SOS-mediated signalling R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250196 SHC1 events in ERBB2 signaling R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1250347 SHC1 events in ERBB4 signaling R-HSA-1251932 PLCG1 events in ERBB2 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1266738 Developmental Biology R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-1306955 GRB7 events in ERBB2 signaling R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling R-HSA-1433557 Signaling by SCF-KIT R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-166520 Signalling by NGF R-HSA-167044 Signalling to RAS R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-169893 Prolonged ERK activation events R-HSA-170968 Frs2-mediated activation R-HSA-170984 ARMS-mediated activation R-HSA-177929 Signaling by EGFR R-HSA-179812 GRB2 events in EGFR signaling R-HSA-180292 GAB1 signalosome R-HSA-180336 SHC1 events in EGFR signaling R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-187687 Signalling to ERKs R-HSA-187706 Signalling to p38 via RIT and RIN R-HSA-190236 Signaling by FGFR R-HSA-194138 Signaling by VEGF R-HSA-1963640 GRB2 events in ERBB2 signaling R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2586552 Signaling by Leptin R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-372790 Signaling by GPCR R-HSA-373755 Semaphorin interactions R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-400685 Sema4D in semaphorin signaling R-HSA-416572 Sema4D induced cell migration and growth-cone collapse R-HSA-422475 Axon guidance R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5663202 Diseases of signal transduction R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5683057 MAPK family signaling cascades R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-912526 Interleukin receptor SHC signaling R-HSA-983705 Signaling by the B Cell Receptor (BCR)",IDA 16314522 21555369 nucleus GO:0005634 IDA GO:0005737 cytoplasm IDA 20010870 plasma membrane GO:0005886 NAS 12000754 plasma membrane GO:0005886 TAS GO:0005886 plasma membrane IDA 16314522 endosome membrane GO:0010008 NAS 15609325 integral component of membrane GO:0016021 IDA 12646923 basolateral plasma membrane GO:0016323 IEA GO:0016324 apical plasma membrane IEA GO:0031410 cytoplasmic vesicle IEA GO:0043209 myelin sheath IDA 7514177 23382219 receptor complex GO:0043235 TAS 7556068 receptor complex GO:0043235 IEA GO:0048471 perinuclear region of cytoplasm,"MAPK cascade GO:0000165 TAS positive regulation of protein phosphorylation GO:0001934 ISS transcription, DNA-templated GO:0006351 IEA protein phosphorylation GO:0006468 10851066 TAS signal transduction GO:0007165 10572067 IDA cell surface receptor signaling pathway GO:0007166 9685399 IDA enzyme linked receptor protein signaling pathway GO:0007167 9590694 TAS transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 7514177 IDA transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 7556068 TAS peripheral nervous system development GO:0007422 IEA heart development GO:0007507 IEA neuromuscular junction development GO:0007528 IEA motor neuron axon guidance GO:0008045 IEA cell proliferation GO:0008283 10851066 TAS phosphatidylinositol 3-kinase signaling GO:0014065 7556068 IDA regulation of phosphatidylinositol 3-kinase signaling GO:0014066 TAS peptidyl-tyrosine phosphorylation GO:0018108 IEA positive regulation of cell growth GO:0030307 21555369 IMP regulation of microtubule-based process GO:0032886 20937854 IDA negative regulation of immature T cell proliferation in thymus GO:0033088 IEA ERBB2 signaling pathway GO:0038128 TAS wound healing GO:0042060 12646923 IDA myelination GO:0042552 IEA positive regulation of MAP kinase activity GO:0043406 10572067 IDA positive regulation of GTPase activity GO:0043547 ISS positive regulation of translation GO:0045727 21555369 IMP regulation of angiogenesis GO:0045765 15609325 NAS positive regulation of cell adhesion GO:0045785 7556068 IDA positive regulation of transcription from RNA polymerase I promoter GO:0045943 21555369 IMP positive regulation of transcription from RNA polymerase III promoter GO:0045945 19372587 IDA protein autophosphorylation GO:0046777 7556068 IDA phosphatidylinositol phosphorylation GO:0046854 IEA phosphatidylinositol-mediated signaling GO:0048015 TAS oligodendrocyte differentiation GO:0048709 IEA positive regulation of epithelial cell proliferation GO:0050679 10572067 IDA regulation of ERK1 and ERK2 cascade GO:0070372 16314522 IMP cellular response to growth factor stimulus GO:0071363 20010870 IDA positive regulation of protein targeting to membrane GO:0090314 20010870 IDA regulation of cell motility GO:2000145 TAS","21555369 GO:0001042 RNA polymerase I core binding IDA 7556068 GO:0004713 protein tyrosine kinase activity IDA 7556068 GO:0004713 protein tyrosine kinase activity IGI GO:0004713 protein tyrosine kinase activity TAS 7514177 GO:0004714 transmembrane receptor protein tyrosine kinase activity IDA GO:0004716 receptor signaling protein tyrosine kinase activity IEA 7514177 GO:0004888 transmembrane signaling receptor activity IDA GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS 7592681 9079677 10572067 10805725 11940572 12061724 12122014 12975581 15657067 16273093 16314522 16516204 16767099 16843263 17426253 19167335 19372587 19411071 19650109 20010870 20227043 20558745 20700126 20876300 21034468 21075308 21255571 21278786 21376233 21555369 21724847 21840311 22279592 22589551 22806884 22939624 23436906 23680147 23688700 23866081 24189400 24412244 24557338 24658140 24815698 25036637 25241761 25640309 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA 15520177 GO:0008022 protein C-terminus binding IPI 7514177 GO:0019838 growth factor binding IDA contributes_to 15899872 GO:0019903 protein phosphatase binding IPI 16843263 19650109 21255571 21480528 23436906 GO:0042802 identical protein binding IPI 9590694 GO:0043125 ErbB-3 class receptor binding TAS GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS 10572067 GO:0046982 protein heterodimerization activity IDA 7556068 GO:0046982 protein heterodimerization activity IPI 12000754 GO:0046983 protein dimerization activity NAS",hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04520 Adherens junction - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05212 Pancreatic cancer - Homo sapiens (human) hsa05213 Endometrial cancer - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05219 Bladder cancer - Homo sapiens (human) hsa05223 Non-small cell lung cancer - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human),chemicalprobes.org TX1-85-1,P21860,Receptor tyrosine-protein kinase erbB-3,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2065,ERBB3,"IRS-mediated signalling R-HSA-112399 SOS-mediated signalling R-HSA-112412 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 SHC1 events in ERBB2 signaling R-HSA-1250196 PI3K events in ERBB4 signaling R-HSA-1250342 SHC1 events in ERBB4 signaling R-HSA-1250347 PIP3 activates AKT signaling R-HSA-1257604 Developmental Biology R-HSA-1266738 Cytokine Signaling in Immune system R-HSA-1280215 Adaptive Immune System R-HSA-1280218 GRB7 events in ERBB2 signaling R-HSA-1306955 Downregulation of ERBB2:ERBB3 signaling R-HSA-1358803 Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Prolonged ERK activation events R-HSA-169893 Frs2-mediated activation R-HSA-170968 ARMS-mediated activation R-HSA-170984 Signaling by EGFR R-HSA-177929 GRB2 events in EGFR signaling R-HSA-179812 GAB1 signalosome R-HSA-180292 SHC1 events in EGFR signaling R-HSA-180336 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signalling to p38 via RIT and RIN R-HSA-187706 Signaling by FGFR R-HSA-190236 Signaling by VEGF R-HSA-194138 GRB2 events in ERBB2 signaling R-HSA-1963640 PI3K events in ERBB2 signaling R-HSA-1963642 PI3K/AKT activation R-HSA-198203 DAP12 interactions R-HSA-2172127 PI3K/AKT Signaling in Cancer R-HSA-2219528 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Signaling by Leptin R-HSA-2586552 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 FCERI mediated MAPK activation R-HSA-2871796 Signaling by GPCR R-HSA-372790 NCAM signaling for neurite out-growth R-HSA-375165 Axon guidance R-HSA-422475 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signaling by Interleukins R-HSA-449147 Interleukin-2 signaling R-HSA-451927 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 VEGFR2 mediated cell proliferation R-HSA-5218921 Downstream signaling of activated FGFR1 R-HSA-5654687 PI-3K cascade:FGFR1 R-HSA-5654689 FRS-mediated FGFR1 signaling R-HSA-5654693 PI-3K cascade:FGFR2 R-HSA-5654695 Downstream signaling of activated FGFR2 R-HSA-5654696 FRS-mediated FGFR2 signaling R-HSA-5654700 FRS-mediated FGFR3 signaling R-HSA-5654706 Downstream signaling of activated FGFR3 R-HSA-5654708 PI-3K cascade:FGFR3 R-HSA-5654710 FRS-mediated FGFR4 signaling R-HSA-5654712 Downstream signaling of activated FGFR4 R-HSA-5654716 PI-3K cascade:FGFR4 R-HSA-5654720 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 Diseases of signal transduction R-HSA-5663202 RAF/MAP kinase cascade R-HSA-5673001 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 Interleukin receptor SHC signaling R-HSA-912526 Signaling by the B Cell Receptor (BCR) R-HSA-983705",11389077 IDA GO:0005615 extracellular space IEA GO:0005622 intracellular 17701904 TAS GO:0005886 plasma membrane 2687875 TAS GO:0005887 integral component of plasma membrane 12646923 IDA GO:0016323 basolateral plasma membrane IEA GO:0016324 apical plasma membrane IEA GO:0016328 lateral plasma membrane 23382219 IDA GO:0043235 receptor complex 7514177 ISS GO:0043235 receptor complex,MAPK cascade TAS GO:0000165 endocardial cushion development IEA GO:0003197 negative regulation of cell adhesion IDA 7556068 GO:0007162 signal transduction IDA 10572067 GO:0007165 transmembrane receptor protein tyrosine kinase signaling pathway ISS 7514177 GO:0007169 peripheral nervous system development ISS GO:0007422 heart development ISS GO:0007507 negative regulation of signal transduction IDA 11389077 GO:0009968 Schwann cell differentiation ISS GO:0014037 phosphatidylinositol 3-kinase signaling IDA 7556068 GO:0014065 regulation of phosphatidylinositol 3-kinase signaling TAS GO:0014066 positive regulation of phosphatidylinositol 3-kinase signaling TAS 17701904 GO:0014068 peptidyl-tyrosine phosphorylation IEA GO:0018108 cranial nerve development ISS GO:0021545 ERBB2 signaling pathway TAS GO:0038128 wound healing NAS 12646923 GO:0042060 regulation of cell proliferation IDA 11389077 GO:0042127 negative regulation of neuron apoptotic process ISS GO:0043524 positive regulation of GTPase activity IEA GO:0043547 phosphatidylinositol phosphorylation IEA GO:0046854 phosphatidylinositol-mediated signaling TAS GO:0048015 negative regulation of secretion IDA 10559227 GO:0051048 neuron apoptotic process IMP 17701904 GO:0051402 positive regulation of protein tyrosine kinase activity IMP 7556068 GO:0061098 positive regulation of calcineurin-NFAT signaling cascade IEA GO:0070886 extrinsic apoptotic signaling pathway in absence of ligand IMP 17701904 GO:0097192 regulation of cell motility TAS GO:2000145,"NOT protein tyrosine kinase activity IDA 7556068 GO:0004713 protein tyrosine kinase activity TAS GO:0004713 transmembrane signaling receptor activity ISS 7514177 GO:0004888 Ras guanyl-nucleotide exchange factor activity TAS GO:0005088 protein binding IPI 7592681 9516479 10572067 16273093 16832058 16843263 17426253 19411071 20227043 21075308 21278786 22439932 22806884 22939624 23436906 23680147 23688700 23866081 24189400 24557338 24658140 25241761 GO:0005515 ATP binding IEA GO:0005524 growth factor binding IPI 11389077 GO:0019838 growth factor binding ISS 7514177 GO:0019838 protein tyrosine kinase activator activity IDA 7556068 GO:0030296 neuregulin binding IDA 20682778 GO:0038132 identical protein binding IPI 21575594 23436906 GO:0042802 protein homodimerization activity NAS 11389077 GO:0042803 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS GO:0046934 protein heterodimerization activity IDA 10572067 GO:0046982 protein heterodimerization activity IPI 7556068 GO:0046982",hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04144 Endocytosis - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human),chemicalprobes.org BI-D1870,Q15418,Ribosomal protein S6 kinase alpha 1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,6195,KS6A1,Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-112314 Transmission across Chemical Synapses R-HSA-112315 Neuronal System R-HSA-112316 Developmental Biology R-HSA-1266738 Signal Transduction R-HSA-162582 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 Activated TLR4 signalling R-HSA-166054 MyD88:Mal cascade initiated on plasma membrane R-HSA-166058 MyD88-independent TLR3/TLR4 cascade R-HSA-166166 Signalling by NGF R-HSA-166520 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168180 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Toll-Like Receptors Cascades R-HSA-168898 Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Nuclear Events (kinase and transcription factor activation) R-HSA-198725 ERK/MAPK targets R-HSA-198753 CREB phosphorylation R-HSA-199920 Cellular responses to stress R-HSA-2262752 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 Cellular Senescence R-HSA-2559583 Signaling by GPCR R-HSA-372790 L1CAM interactions R-HSA-373760 Axon guidance R-HSA-422475 Recycling pathway of L1 R-HSA-437239 Post NMDA receptor activation events R-HSA-438064 CREB phosphorylation through the activation of Ras R-HSA-442742 Activation of NMDA receptor upon glutamate binding and postsynaptic events R-HSA-442755 RSK activation R-HSA-444257 MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 MAP kinase activation in TLR cascade R-HSA-450294 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 TRIF-mediated TLR3/TLR4 signaling R-HSA-937061 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 MyD88 dependent cascade initiated on endosome R-HSA-975155 MyD88 cascade initiated on plasma membrane R-HSA-975871,IBA GO:0005634 nucleus IDA GO:0005634 nucleus TAS GO:0005654 nucleoplasm IBA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm TAS GO:0005829 cytosol,protein phosphorylation IEA GO:0006468 cell cycle IEA GO:0007049 signal transduction TAS 8141249 GO:0007165 positive regulation of cell growth TAS 18813292 GO:0030307 intracellular signal transduction IBA GO:0035556 negative regulation of apoptotic process IMP 11684016 GO:0043066 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA 18402937 GO:0043154 regulation of translation in response to stress TAS 18813292 GO:0043555 regulation of DNA-templated transcription in response to stress TAS 18813292 GO:0043620 positive regulation of cell differentiation TAS 18813292 GO:0045597 positive regulation of transcription from RNA polymerase II promoter IMP 22065586 GO:0045944 hepatocyte proliferation ISS GO:0072574 positive regulation of hepatic stellate cell activation IMP 10679322 GO:2000491,magnesium ion binding IEA GO:0000287 protein serine/threonine kinase activity IDA 10679322 22357623 GO:0004674 protein serine/threonine kinase activity TAS GO:0004674 protein serine/threonine/tyrosine kinase activity IDA 22797923 GO:0004712 protein binding IPI 21423205 22130794 22939624 23455922 GO:0005515 ATP binding IEA GO:0005524 kinase activity TAS GO:0016301 cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA 18402937 GO:0043027,hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04114 Oocyte meiosis - Homo sapiens (human) hsa04150 mTOR signaling pathway - Homo sapiens (human) hsa04720 Long-term potentiation - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human),chemicalprobes.org BI-D1870,Q15349,Ribosomal protein S6 kinase alpha 2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,6196,KS6A2,Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-112314 Transmission across Chemical Synapses R-HSA-112315 Neuronal System R-HSA-112316 Developmental Biology R-HSA-1266738 Signal Transduction R-HSA-162582 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 Activated TLR4 signalling R-HSA-166054 MyD88:Mal cascade initiated on plasma membrane R-HSA-166058 MyD88-independent TLR3/TLR4 cascade R-HSA-166166 Signalling by NGF R-HSA-166520 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168180 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Toll-Like Receptors Cascades R-HSA-168898 Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Nuclear Events (kinase and transcription factor activation) R-HSA-198725 ERK/MAPK targets R-HSA-198753 CREB phosphorylation R-HSA-199920 Cellular responses to stress R-HSA-2262752 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559582 Cellular Senescence R-HSA-2559583 Signaling by GPCR R-HSA-372790 L1CAM interactions R-HSA-373760 Axon guidance R-HSA-422475 Recycling pathway of L1 R-HSA-437239 Post NMDA receptor activation events R-HSA-438064 CREB phosphorylation through the activation of Ras R-HSA-442742 Activation of NMDA receptor upon glutamate binding and postsynaptic events R-HSA-442755 RSK activation R-HSA-444257 MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 MAP kinase activation in TLR cascade R-HSA-450294 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 TRIF-mediated TLR3/TLR4 signaling R-HSA-937061 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 MyD88 dependent cascade initiated on endosome R-HSA-975155 MyD88 cascade initiated on plasma membrane R-HSA-975871,16878154 IDA GO:0005634 nucleus IDA GO:0005654 nucleoplasm TAS GO:0005654 nucleoplasm 16878154 IDA GO:0005737 cytoplasm IEA GO:0005819 spindle TAS GO:0005829 cytosol IDA GO:0031965 nuclear membrane,GO:0001556 oocyte maturation IEA GO:0002035 brain renin-angiotensin system IEA GO:0007165 signal transduction 7623830 NAS GO:0007507 heart development IEA GO:0008285 negative regulation of cell proliferation 16878154 IDA GO:0010628 positive regulation of gene expression IEA GO:0010659 cardiac muscle cell apoptotic process IEA GO:0018105 peptidyl-serine phosphorylation IEA GO:0035556 intracellular signal transduction IEA GO:0043065 positive regulation of apoptotic process 16878154 IDA GO:0045786 negative regulation of cell cycle 16878154 IDA GO:0045835 negative regulation of meiotic nuclear division IEA GO:0060047 heart contraction IEA GO:0070613 regulation of protein processing IEA GO:0071322 cellular response to carbohydrate stimulus IEA,GO:0000287 magnesium ion binding IEA GO:0004674 protein serine/threonine kinase activity TAS GO:0004711 ribosomal protein S6 kinase activity IEA GO:0004712 protein serine/threonine/tyrosine kinase activity 22797923 IDA GO:0005515 protein binding 16810323 23602568 25241761 IPI GO:0005524 ATP binding IEA GO:0016301 kinase activity TAS,hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04114 Oocyte meiosis - Homo sapiens (human) hsa04150 mTOR signaling pathway - Homo sapiens (human) hsa04720 Long-term potentiation - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human),chemicalprobes.org BI-D1870,P51812,Ribosomal protein S6 kinase alpha 3,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,6197,KS6A3,R-HSA-112314 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System R-HSA-1266738 Developmental Biology R-HSA-162582 Signal Transduction R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166054 Activated TLR4 signalling R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-166166 MyD88-independent TLR3/TLR4 cascade R-HSA-166520 Signalling by NGF R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168180 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-168898 Toll-Like Receptors Cascades R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-198725 Nuclear Events (kinase and transcription factor activation) R-HSA-198753 ERK/MAPK targets R-HSA-199920 CREB phosphorylation R-HSA-2262752 Cellular responses to stress R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559583 Cellular Senescence R-HSA-372790 Signaling by GPCR R-HSA-373760 L1CAM interactions R-HSA-422475 Axon guidance R-HSA-437239 Recycling pathway of L1 R-HSA-438064 Post NMDA receptor activation events R-HSA-442742 CREB phosphorylation through the activation of Ras R-HSA-442755 Activation of NMDA receptor upon glutamate binding and postsynaptic events R-HSA-444257 RSK activation R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450294 MAP kinase activation in TLR cascade R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-937061 TRIF-mediated TLR3/TLR4 signaling R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-975871 MyD88 cascade initiated on plasma membrane,nucleus GO:0005634 IBA nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 IBA cytosol GO:0005829 TAS,skeletal system development GO:0001501 TAS 8955270 toll-like receptor signaling pathway GO:0002224 ISS protein phosphorylation GO:0006468 IEA cell cycle GO:0007049 IEA signal transduction GO:0007165 TAS 10436156 central nervous system development GO:0007417 TAS 10319851 positive regulation of cell growth GO:0030307 TAS 18813292 response to lipopolysaccharide GO:0032496 ISS intracellular signal transduction GO:0035556 IBA negative regulation of apoptotic process GO:0043066 TAS 18813292 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IDA 18402937 regulation of translation in response to stress GO:0043555 TAS 18813292 regulation of DNA-templated transcription in response to stress GO:0043620 TAS 18813292 positive regulation of cell differentiation GO:0045597 TAS 18813292 positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP 22065586,magnesium ion binding GO:0000287 IEA protein kinase activity GO:0004672 TAS 10436156 protein serine/threonine kinase activity GO:0004674 TAS protein binding GO:0005515 IPI 21988832 23602568 25241761 ATP binding GO:0005524 IEA kinase activity GO:0016301 TAS protein kinase binding GO:0019901 IEA cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 IDA 18402937,MAPK signaling pathway - Homo sapiens (human) hsa04010 Oocyte meiosis - Homo sapiens (human) hsa04114 mTOR signaling pathway - Homo sapiens (human) hsa04150 Long-term potentiation - Homo sapiens (human) hsa04720 Neurotrophin signaling pathway - Homo sapiens (human) hsa04722 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04914,chemicalprobes.org BI-D1870,Q9UK32,Ribosomal protein S6 kinase alpha 6,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,27330,KS6A6,Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-112314 Transmission across Chemical Synapses R-HSA-112315 Neuronal System R-HSA-112316 Developmental Biology R-HSA-1266738 L1CAM interactions R-HSA-373760 Axon guidance R-HSA-422475 Recycling pathway of L1 R-HSA-437239 Post NMDA receptor activation events R-HSA-438064 CREB phosphorylation through the activation of Ras R-HSA-442742 Activation of NMDA receptor upon glutamate binding and postsynaptic events R-HSA-442755 RSK activation R-HSA-444257,nucleus GO:0005634 IBA nucleus GO:0005634 IDA nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS nucleolus GO:0005730 IDA cytoplasm GO:0005737 IBA mitochondrion GO:0005739 IDA cytosol GO:0005829 TAS,"IEA GO:0006468 protein phosphorylation IMP 15042092 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 TAS 10644430 signal transduction GO:0007165 TAS 10644430 central nervous system development GO:0007417 ISS GO:0045992 negative regulation of embryonic development ISS GO:0070373 negative regulation of ERK1 and ERK2 cascade ISS GO:2000381 negative regulation of mesoderm development",IEA GO:0000287 magnesium ion binding TAS 10644430 protein kinase activity GO:0004672 IBA GO:0004674 protein serine/threonine kinase activity IEA GO:0005524 ATP binding TAS GO:0016301 kinase activity,hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04114 Oocyte meiosis - Homo sapiens (human) hsa04150 mTOR signaling pathway - Homo sapiens (human) hsa04720 Long-term potentiation - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human),chemicalprobes.org KU-60019,Q13315,Serine-protein kinase ATM,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,472,ATM,R-HSA-1640170 Cell Cycle R-HSA-2262752 Cellular responses to stress R-HSA-2559583 Cellular Senescence R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-3371556 Cellular response to heat stress R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-419524 Fanconi Anemia pathway R-HSA-419552 Regulation of the Fanconi anemia pathway R-HSA-5685940 DNA Double Strand Breaks Response R-HSA-69473 G2/M DNA damage checkpoint R-HSA-69481 G2/M Checkpoints R-HSA-69541 Stabilization of p53 R-HSA-69563 p53-Dependent G1 DNA Damage Response R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69610 p53-Independent DNA Damage Response R-HSA-69613 p53-Independent G1/S DNA damage checkpoint R-HSA-69615 G1/S DNA Damage Checkpoints R-HSA-69620 Cell Cycle Checkpoints R-HSA-73888 Homologous Recombination Repair R-HSA-73890 Double-Strand Break Repair R-HSA-73894 DNA Repair R-HSA-73951 Homologous recombination repair of replication-independent double-strand breaks R-HSA-75148 ATM mediated phosphorylation of repair proteins R-HSA-75154 Recruitment of repair and signaling proteins to double-strand breaks R-HSA-83542 ATM mediated response to DNA double-strand break,"15149599 GO:0000781 chromosome, telomeric region IDA colocalizes_with 26586433 GO:0000784 nuclear chromosome, telomeric region IC colocalizes_with GO:0005634 nucleus IBA GO:0005654 nucleoplasm TAS GO:0005819 spindle IEA GO:0016023 cytoplasmic, membrane-bounded vesicle IEA 24217620 GO:1990391 DNA repair complex IDA","IEA GO:0000724 double-strand break repair via homologous recombination TAS GO:0000729 DNA double-strand break processing TAS GO:0000731 DNA synthesis involved in DNA repair TAS GO:0000732 strand displacement IEA GO:0001666 response to hypoxia IEA GO:0001756 somitogenesis ISS GO:0002331 pre-B cell allelic exclusion TAS GO:0006260 DNA replication IBA GO:0006281 DNA repair TAS GO:0006303 double-strand break repair via nonhomologous end joining IDA 15916964 protein phosphorylation GO:0006468 IMP 17694070 protein phosphorylation GO:0006468 IMP 15790808 17875758 24550317 cellular response to DNA damage stimulus GO:0006974 IDA 9733515 DNA damage induced protein phosphorylation GO:0006975 TAS GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IGI 26586433 telomere maintenance via telomerase GO:0007004 IMP 15149599 cell cycle arrest GO:0007050 IMP 11943150 mitotic spindle assembly checkpoint GO:0007094 TAS 7792600 reciprocal meiotic recombination GO:0007131 TAS 7792600 signal transduction GO:0007165 IEA GO:0007420 brain development IEA GO:0007507 heart development IEA GO:0008340 determination of adult lifespan IEA GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IDA 9733515 11375976 response to ionizing radiation GO:0010212 IMP 23878245 regulation of autophagy GO:0010506 IEA GO:0016572 histone phosphorylation IDA 9733515 peptidyl-serine phosphorylation GO:0018105 IMP 17875758 negative regulation of B cell proliferation GO:0030889 ISS GO:0032212 positive regulation of telomere maintenance via telomerase IEA GO:0033129 positive regulation of histone phosphorylation IEA GO:0033151 V(D)J recombination IEA GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IMP 24550317 peptidyl-serine autophosphorylation GO:0036289 IEA GO:0042159 lipoprotein catabolic process TAS GO:0042981 regulation of apoptotic process IMP 17875758 positive regulation of apoptotic process GO:0043065 IMP 9733515 positive regulation of DNA damage response, signal transduction by p53 class mediator GO:0043517 IEA GO:0043525 positive regulation of neuron apoptotic process IEA GO:0045141 meiotic telomere clustering IDA 9733515 15790808 protein autophosphorylation GO:0046777 IEA GO:0048599 oocyte development IEA GO:0051402 neuron apoptotic process IMP NOT 26586427 regulation of telomerase activity GO:0051972 IDA 16086026 histone mRNA catabolic process GO:0071044 IDA 9925639 cellular response to gamma radiation GO:0071480 IDA 23878245 cellular response to nitrosative stress GO:0071500 IMP 15149599 signal transduction involved in mitotic G2 DNA damage checkpoint GO:0072434 IMP 15149599 replicative senescence GO:0090399 IMP 26586433 establishment of RNA localization to telomere GO:0097694 IC 26586433 establishment of macromolecular complex localization to telomere GO:0097695 TAS GO:1900034 regulation of cellular response to heat TAS GO:1901796 regulation of signal transduction by p53 class mediator IMP 23878245 negative regulation of TORC1 signaling GO:1904262 IMP 17694070 negative regulation of telomere capping GO:1904354 IMP 17694070 26586427 positive regulation of telomere maintenance via telomere lengthening GO:1904358 IMP 26586433 positive regulation of telomerase catalytic core complex assembly GO:1904884",IEA GO:0003677 DNA binding IDA 9733515 11375976 20096447 protein serine/threonine kinase activity GO:0004674 TAS GO:0004674 protein serine/threonine kinase activity IDA 15790808 DNA-dependent protein kinase activity GO:0004677 IPI 11375976 12607005 16452482 17157788 17525732 18160036 18449195 18583959 18667510 18710941 20801936 20810650 20864032 22977523 25640309 protein binding GO:0005515 IEA GO:0005524 ATP binding IMP 11375976 1-phosphatidylinositol-3-kinase activity GO:0016303 IDA 15790808 protein complex binding GO:0032403 IDA 15790808 protein dimerization activity GO:0046983 IDA 11375976 protein N-terminus binding GO:0047485,NF-kappa B signaling pathway - Homo sapiens (human) hsa04064 FoxO signaling pathway - Homo sapiens (human) hsa04068 Cell cycle - Homo sapiens (human) hsa04110 p53 signaling pathway - Homo sapiens (human) hsa04115 Apoptosis - Homo sapiens (human) hsa04210 HTLV-I infection - Homo sapiens (human) hsa05166 Transcriptional misregulation in cancer - Homo sapiens (human) hsa05202 MicroRNAs in cancer - Homo sapiens (human) hsa05206,chemicalprobes.org VE-821,Q13535,Serine-protein kinase ATR,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,545,ATR,Meiotic synapsis R-HSA-1221632 Meiosis R-HSA-1500620 Cell Cycle R-HSA-1640170 Activation of ATR in response to replication stress R-HSA-176187 Cellular responses to stress R-HSA-2262752 Regulation of HSF1-mediated heat shock response R-HSA-3371453 Cellular response to heat stress R-HSA-3371556 Fanconi Anemia pathway R-HSA-419524 Regulation of the Fanconi anemia pathway R-HSA-419552 G2/M DNA damage checkpoint R-HSA-69473 G2/M Checkpoints R-HSA-69481 Cell Cycle Checkpoints R-HSA-69620 DNA Repair R-HSA-73894,"IC colocalizes_with 26586433 nuclear chromosome, telomeric region GO:0000784 IDA GO:0005654 nucleoplasm TAS GO:0005654 nucleoplasm ISS GO:0005694 chromosome IDA GO:0005794 Golgi apparatus IDA 12814551 PML body GO:0016605","DNA damage checkpoint 14657349 GO:0000077 IDA DNA replication GO:0006260 TAS DNA repair 8610130 GO:0006281 TAS cellular response to DNA damage stimulus 15538388 GO:0006974 TAS cell cycle 9590286 GO:0007049 TAS multicellular organism development 9590286 GO:0007275 TAS negative regulation of DNA replication 14657349 GO:0008156 IMP peptidyl-serine phosphorylation 9733515 GO:0018105 IDA positive regulation of telomere maintenance via telomerase GO:0032212 ISS cellular response to UV 9925639 GO:0034644 IMP interstrand cross-link repair GO:0036297 TAS response to drug GO:0042493 IEA positive regulation of DNA damage response, signal transduction by p53 class mediator 9925639 GO:0043517 IMP protein autophosphorylation 9733515 GO:0046777 IDA protein localization to chromosome, telomeric region 21829167 GO:0070198 IMP cellular response to gamma radiation 9925639 GO:0071480 IDA replicative senescence 15149599 GO:0090399 IMP establishment of RNA localization to telomere 26586433 GO:0097694 IMP establishment of macromolecular complex localization to telomere 26586433 GO:0097695 IC regulation of cellular response to heat GO:1900034 TAS regulation of signal transduction by p53 class mediator GO:1901796 TAS positive regulation of telomerase catalytic core complex assembly 26586433 GO:1904884 IMP",GO:0003677 DNA binding IEA 14657349 GO:0004672 protein kinase activity IDA 9733515 9925639 GO:0004674 protein serine/threonine kinase activity IDA GO:0004674 protein serine/threonine kinase activity TAS 14657349 18583959 19633697 20810650 20864032 20930849 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA 16713580 GO:0032405 MutLalpha complex binding IDA 16713580 GO:0032407 MutSalpha complex binding IDA,hsa03460 Fanconi anemia pathway - Homo sapiens (human) hsa04110 Cell cycle - Homo sapiens (human) hsa04115 p53 signaling pathway - Homo sapiens (human) hsa05166 HTLV-I infection - Homo sapiens (human),chemicalprobes.org MK-5108,O14965,Serine/threonine-protein kinase Aurora-A,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,6790,AURKA,"Cell Cycle R-HSA-1640170 APC/C-mediated degradation of cell cycle proteins R-HSA-174143 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 Mitotic G2-G2/M phases R-HSA-453274 Regulation of mitotic cell cycle R-HSA-453276 G2/M Transition R-HSA-69275 Cell Cycle, Mitotic R-HSA-69278","IBA GO:0000780 condensed nuclear chromosome, centromeric region 20531406 IDA GO:0005634 nucleus TAS GO:0005654 nucleoplasm 17726514 21399614 21600873 IDA GO:0005813 centrosome 19774610 TAS GO:0005813 centrosome IEA GO:0005814 centriole 19774610 TAS GO:0005819 spindle TAS GO:0005829 cytosol 19801554 IDA GO:0005876 colocalizes_with spindle microtubule IEA GO:0005929 cilium 19801554 IDA GO:0015630 microtubule cytoskeleton 19774610 TAS GO:0030496 midbody 19801554 IDA GO:0031616 spindle pole centrosome IBA GO:0032133 chromosome passenger complex IEA GO:0042585 germinal vesicle IEA GO:0043203 axon hillock IEA GO:0045120 pronucleus 20531406 IDA GO:0048471 perinuclear region of cytoplasm IBA GO:0051233 spindle midzone IEA GO:0072686 mitotic spindle IEA GO:0072687 meiotic spindle","G2/M transition of mitotic cell cycle GO:0000086 TAS protein phosphorylation 21600873 21820309 GO:0006468 IDA DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 TAS spindle organization 21820309 GO:0007051 IMP mitotic spindle organization GO:0007052 IBA spindle assembly involved in female meiosis I GO:0007057 IEA mitotic nuclear division 9153231 GO:0007067 TAS mitotic centrosome separation GO:0007100 IEA anterior/posterior axis specification GO:0009948 IEA anaphase-promoting complex-dependent catabolic process GO:0031145 TAS regulation of protein stability 15987997 GO:0031647 IMP negative regulation of protein binding 21820309 GO:0032091 IDA response to estradiol GO:0032355 IEA positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IEA regulation of cytokinesis GO:0032465 IBA histone-serine phosphorylation GO:0035404 IEA protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 TAS negative regulation of apoptotic process GO:0043066 IEA positive regulation of mitotic nuclear division 19774610 GO:0045840 TAS regulation of centrosome cycle 19774610 GO:0046605 TAS protein autophosphorylation 19774610 GO:0046777 TAS cell division GO:0051301 IEA centrosome localization GO:0051642 IEA protein localization to centrosome GO:0071539 IEA positive regulation of oocyte maturation GO:1900195 IEA regulation of signal transduction by p53 class mediator GO:1901796 TAS neuron projection extension GO:1990138 IEA",protein kinase activity IDA 14580337 19801554 21600873 GO:0004672 protein serine/threonine kinase activity EXP 13678582 18566290 21807936 GO:0004674 protein serine/threonine kinase activity TAS GO:0004674 protein serine/threonine/tyrosine kinase activity TAS 19774610 GO:0004712 protein binding IPI 12244051 14580337 15987997 17726514 18521620 18662907 18663142 19111882 19801554 20360068 20596670 20643351 21821029 22014574 22306998 22340593 23520446 23792191 24857377 24996188 25175806 GO:0005515 ATP binding IEA GO:0005524 protein kinase binding IPI 18615013 GO:0019901 ubiquitin protein ligase binding IEA GO:0031625 histone serine kinase activity IBA GO:0035174,Oocyte meiosis - Homo sapiens (human) hsa04114,chemicalprobes.org AMG900,O14965,Serine/threonine-protein kinase Aurora-A,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,6790,AURKA,"Cell Cycle R-HSA-1640170 APC/C-mediated degradation of cell cycle proteins R-HSA-174143 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 Mitotic G2-G2/M phases R-HSA-453274 Regulation of mitotic cell cycle R-HSA-453276 G2/M Transition R-HSA-69275 Cell Cycle, Mitotic R-HSA-69278","IBA GO:0000780 condensed nuclear chromosome, centromeric region 20531406 IDA GO:0005634 nucleus TAS GO:0005654 nucleoplasm 17726514 21399614 21600873 IDA GO:0005813 centrosome 19774610 TAS GO:0005813 centrosome IEA GO:0005814 centriole 19774610 TAS GO:0005819 spindle TAS GO:0005829 cytosol 19801554 IDA GO:0005876 colocalizes_with spindle microtubule IEA GO:0005929 cilium 19801554 IDA GO:0015630 microtubule cytoskeleton 19774610 TAS GO:0030496 midbody 19801554 IDA GO:0031616 spindle pole centrosome IBA GO:0032133 chromosome passenger complex IEA GO:0042585 germinal vesicle IEA GO:0043203 axon hillock IEA GO:0045120 pronucleus 20531406 IDA GO:0048471 perinuclear region of cytoplasm IBA GO:0051233 spindle midzone IEA GO:0072686 mitotic spindle IEA GO:0072687 meiotic spindle","G2/M transition of mitotic cell cycle GO:0000086 TAS protein phosphorylation 21600873 21820309 GO:0006468 IDA DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 TAS spindle organization 21820309 GO:0007051 IMP mitotic spindle organization GO:0007052 IBA spindle assembly involved in female meiosis I GO:0007057 IEA mitotic nuclear division 9153231 GO:0007067 TAS mitotic centrosome separation GO:0007100 IEA anterior/posterior axis specification GO:0009948 IEA anaphase-promoting complex-dependent catabolic process GO:0031145 TAS regulation of protein stability 15987997 GO:0031647 IMP negative regulation of protein binding 21820309 GO:0032091 IDA response to estradiol GO:0032355 IEA positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IEA regulation of cytokinesis GO:0032465 IBA histone-serine phosphorylation GO:0035404 IEA protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 TAS negative regulation of apoptotic process GO:0043066 IEA positive regulation of mitotic nuclear division 19774610 GO:0045840 TAS regulation of centrosome cycle 19774610 GO:0046605 TAS protein autophosphorylation 19774610 GO:0046777 TAS cell division GO:0051301 IEA centrosome localization GO:0051642 IEA protein localization to centrosome GO:0071539 IEA positive regulation of oocyte maturation GO:1900195 IEA regulation of signal transduction by p53 class mediator GO:1901796 TAS neuron projection extension GO:1990138 IEA",protein kinase activity IDA 14580337 19801554 21600873 GO:0004672 protein serine/threonine kinase activity EXP 13678582 18566290 21807936 GO:0004674 protein serine/threonine kinase activity TAS GO:0004674 protein serine/threonine/tyrosine kinase activity TAS 19774610 GO:0004712 protein binding IPI 12244051 14580337 15987997 17726514 18521620 18662907 18663142 19111882 19801554 20360068 20596670 20643351 21821029 22014574 22306998 22340593 23520446 23792191 24857377 24996188 25175806 GO:0005515 ATP binding IEA GO:0005524 protein kinase binding IPI 18615013 GO:0019901 ubiquitin protein ligase binding IEA GO:0031625 histone serine kinase activity IBA GO:0035174,Oocyte meiosis - Homo sapiens (human) hsa04114,chemicalprobes.org AMG900,Q96GD4,Serine/threonine-protein kinase Aurora-B,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,9212,AURKB,"Signal Transduction R-HSA-162582 Cell Cycle R-HSA-1640170 APC/C-mediated degradation of cell cycle proteins R-HSA-174143 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 Signaling by Rho GTPases R-HSA-194315 RHO GTPase Effectors R-HSA-195258 Separation of Sister Chromatids R-HSA-2467813 Resolution of Sister Chromatid Cohesion R-HSA-2500257 Mitotic Metaphase and Anaphase R-HSA-2555396 Regulation of mitotic cell cycle R-HSA-453276 RHO GTPases Activate Formins R-HSA-5663220 Mitotic Prometaphase R-HSA-68877 Mitotic Anaphase R-HSA-68882 M Phase R-HSA-68886 Cell Cycle, Mitotic R-HSA-69278","IDA colocalizes_with 22024163 kinetochore GO:0000776 IDA 19465021 condensed chromosome, centromeric region GO:0000779 IDA 18195732 condensed nuclear chromosome, centromeric region GO:0000780 IDA 20959462 nucleus GO:0005634 IDA GO:0005654 nucleoplasm TAS GO:0005654 nucleoplasm TAS 19774610 spindle GO:0005819 TAS GO:0005829 cytosol IBA GO:0005876 spindle microtubule IEA GO:0010369 chromocenter IDA 17726514 midbody GO:0030496 TAS 19774610 midbody GO:0030496 IBA GO:0031616 spindle pole centrosome IPI 15260989 18591255 chromosome passenger complex GO:0032133 TAS 19774610 chromosome passenger complex GO:0032133 IDA GO:0045171 intercellular bridge IBA GO:0051233 spindle midzone",negative regulation of transcription from RNA polymerase II promoter GO:0000122 20959462 IDA negative regulation of B cell apoptotic process GO:0002903 20959462 IDA protein phosphorylation GO:0006468 21820309 22724069 IDA spindle organization GO:0007051 21820309 IMP sister chromatid cohesion GO:0007062 TAS aging GO:0007568 IEA cell proliferation GO:0008283 IEA attachment of spindle microtubules to kinetochore GO:0008608 19774610 TAS abscission GO:0009838 ISS histone modification GO:0016570 19774610 TAS protein sumoylation GO:0016925 TAS anaphase-promoting complex-dependent catabolic process GO:0031145 TAS spindle checkpoint GO:0031577 IEA negative regulation of protein binding GO:0032091 21820309 IDA positive regulation of telomere maintenance via telomerase GO:0032212 21531765 IMP negative regulation of cytokinesis GO:0032466 ISS positive regulation of cytokinesis GO:0032467 16103226 IMP positive regulation of cytokinesis GO:0032467 19774610 TAS protein localization to kinetochore GO:0034501 19468067 IMP cellular response to UV GO:0034644 20959462 IDA cleavage furrow formation GO:0036089 16103226 IDA protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 TAS histone H3-S28 phosphorylation GO:0043988 ISS protein autophosphorylation GO:0046777 19774610 TAS mitotic spindle midzone assembly GO:0051256 16103226 IMP mitotic spindle midzone assembly GO:0051256 19774610 TAS positive regulation of telomerase activity GO:0051973 21531765 IMP regulation of chromosome segregation GO:0051983 19774610 TAS regulation of signal transduction by p53 class mediator GO:1901796 TAS positive regulation of telomere capping GO:1904355 21531765 IMP,21397845 GO:0004674 protein serine/threonine kinase activity EXP 22724069 GO:0004674 protein serine/threonine kinase activity IDA GO:0004674 protein serine/threonine kinase activity TAS 19774610 GO:0004712 protein serine/threonine/tyrosine kinase activity TAS 12689593 15064709 16179162 16239925 16291752 17099693 17681274 17726514 17956729 20562864 20959462 21051298 21988832 22939624 24571573 24857377 25036637 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0035174 histone serine kinase activity IBA GO:0035174 histone serine kinase activity ISS GO:0046872 metal ion binding IEA,,chemicalprobes.org AZD1152-HQPA,Q96GD4,Serine/threonine-protein kinase Aurora-B,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,9212,AURKB,"Signal Transduction R-HSA-162582 Cell Cycle R-HSA-1640170 APC/C-mediated degradation of cell cycle proteins R-HSA-174143 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 Signaling by Rho GTPases R-HSA-194315 RHO GTPase Effectors R-HSA-195258 Separation of Sister Chromatids R-HSA-2467813 Resolution of Sister Chromatid Cohesion R-HSA-2500257 Mitotic Metaphase and Anaphase R-HSA-2555396 Regulation of mitotic cell cycle R-HSA-453276 RHO GTPases Activate Formins R-HSA-5663220 Mitotic Prometaphase R-HSA-68877 Mitotic Anaphase R-HSA-68882 M Phase R-HSA-68886 Cell Cycle, Mitotic R-HSA-69278","IDA colocalizes_with 22024163 kinetochore GO:0000776 IDA 19465021 condensed chromosome, centromeric region GO:0000779 IDA 18195732 condensed nuclear chromosome, centromeric region GO:0000780 IDA 20959462 nucleus GO:0005634 IDA GO:0005654 nucleoplasm TAS GO:0005654 nucleoplasm TAS 19774610 spindle GO:0005819 TAS GO:0005829 cytosol IBA GO:0005876 spindle microtubule IEA GO:0010369 chromocenter IDA 17726514 midbody GO:0030496 TAS 19774610 midbody GO:0030496 IBA GO:0031616 spindle pole centrosome IPI 15260989 18591255 chromosome passenger complex GO:0032133 TAS 19774610 chromosome passenger complex GO:0032133 IDA GO:0045171 intercellular bridge IBA GO:0051233 spindle midzone",negative regulation of transcription from RNA polymerase II promoter GO:0000122 20959462 IDA negative regulation of B cell apoptotic process GO:0002903 20959462 IDA protein phosphorylation GO:0006468 21820309 22724069 IDA spindle organization GO:0007051 21820309 IMP sister chromatid cohesion GO:0007062 TAS aging GO:0007568 IEA cell proliferation GO:0008283 IEA attachment of spindle microtubules to kinetochore GO:0008608 19774610 TAS abscission GO:0009838 ISS histone modification GO:0016570 19774610 TAS protein sumoylation GO:0016925 TAS anaphase-promoting complex-dependent catabolic process GO:0031145 TAS spindle checkpoint GO:0031577 IEA negative regulation of protein binding GO:0032091 21820309 IDA positive regulation of telomere maintenance via telomerase GO:0032212 21531765 IMP negative regulation of cytokinesis GO:0032466 ISS positive regulation of cytokinesis GO:0032467 16103226 IMP positive regulation of cytokinesis GO:0032467 19774610 TAS protein localization to kinetochore GO:0034501 19468067 IMP cellular response to UV GO:0034644 20959462 IDA cleavage furrow formation GO:0036089 16103226 IDA protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 TAS histone H3-S28 phosphorylation GO:0043988 ISS protein autophosphorylation GO:0046777 19774610 TAS mitotic spindle midzone assembly GO:0051256 16103226 IMP mitotic spindle midzone assembly GO:0051256 19774610 TAS positive regulation of telomerase activity GO:0051973 21531765 IMP regulation of chromosome segregation GO:0051983 19774610 TAS regulation of signal transduction by p53 class mediator GO:1901796 TAS positive regulation of telomere capping GO:1904355 21531765 IMP,21397845 GO:0004674 protein serine/threonine kinase activity EXP 22724069 GO:0004674 protein serine/threonine kinase activity IDA GO:0004674 protein serine/threonine kinase activity TAS 19774610 GO:0004712 protein serine/threonine/tyrosine kinase activity TAS 12689593 15064709 16179162 16239925 16291752 17099693 17681274 17726514 17956729 20562864 20959462 21051298 21988832 22939624 24571573 24857377 25036637 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0035174 histone serine kinase activity IBA GO:0035174 histone serine kinase activity ISS GO:0046872 metal ion binding IEA,,chemicalprobes.org AMG900,Q9UQB9,Serine/threonine-protein kinase Aurora-C,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,6795,AURKC,,"IBA GO:0000780 condensed nuclear chromosome, centromeric region 15670791 IDA GO:0000793 condensed chromosome IEA GO:0005737 cytoplasm 19774610 TAS GO:0005819 spindle IBA GO:0005876 spindle microtubule 15670791 IDA GO:0030496 midbody 19774610 TAS GO:0030496 midbody IBA GO:0031616 spindle pole centrosome 19774610 TAS GO:0032133 chromosome passenger complex 15670791 IDA GO:0051233 spindle midzone",cytokinesis GO:0000910 IEA protein phosphorylation 15670791 GO:0006468 IDA spermatogenesis GO:0007283 IEA attachment of spindle microtubules to kinetochore 19774610 GO:0008608 TAS histone modification 19774610 GO:0016570 TAS positive regulation of cytokinesis 19774610 GO:0032467 TAS histone-serine phosphorylation GO:0035404 IEA oocyte development GO:0048599 IEA mitotic spindle midzone assembly 19774610 GO:0051256 TAS meiotic cell cycle GO:0051321 IEA,protein kinase activity IDA 15670791 GO:0004672 protein serine/threonine/tyrosine kinase activity TAS 19774610 GO:0004712 ATP binding IEA GO:0005524 histone serine kinase activity IBA GO:0035174,,chemicalprobes.org GDC-0879,P15056,Serine/threonine-protein kinase B-raf,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,673,BRAF,"Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-112314 Transmission across Chemical Synapses R-HSA-112315 Neuronal System R-HSA-112316 IRS-mediated signalling R-HSA-112399 SOS-mediated signalling R-HSA-112412 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 SHC1 events in ERBB2 signaling R-HSA-1250196 SHC1 events in ERBB4 signaling R-HSA-1250347 Developmental Biology R-HSA-1266738 Cytokine Signaling in Immune system R-HSA-1280215 Spry regulation of FGF signaling R-HSA-1295596 Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Prolonged ERK activation events R-HSA-169893 Frs2-mediated activation R-HSA-170968 ARMS-mediated activation R-HSA-170984 Signaling by EGFR R-HSA-177929 GRB2 events in EGFR signaling R-HSA-179812 SHC1 events in EGFR signaling R-HSA-180336 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signalling to p38 via RIT and RIN R-HSA-187706 Signaling by FGFR R-HSA-190236 Signaling by VEGF R-HSA-194138 GRB2 events in ERBB2 signaling R-HSA-1963640 DAP12 interactions R-HSA-2172127 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Signaling by Leptin R-HSA-2586552 FCERI mediated MAPK activation R-HSA-2871796 Signaling by GPCR R-HSA-372790 NCAM signaling for neurite out-growth R-HSA-375165 Axon guidance R-HSA-422475 Post NMDA receptor activation events R-HSA-438064 VEGFA-VEGFR2 Pathway R-HSA-4420097 CREB phosphorylation through the activation of Ras R-HSA-442742 Activation of NMDA receptor upon glutamate binding and postsynaptic events R-HSA-442755 Signaling by Interleukins R-HSA-449147 Interleukin-2 signaling R-HSA-451927 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 VEGFR2 mediated cell proliferation R-HSA-5218921 Downstream signaling of activated FGFR1 R-HSA-5654687 FRS-mediated FGFR1 signaling R-HSA-5654693 Downstream signaling of activated FGFR2 R-HSA-5654696 FRS-mediated FGFR2 signaling R-HSA-5654700 FRS-mediated FGFR3 signaling R-HSA-5654706 Downstream signaling of activated FGFR3 R-HSA-5654708 FRS-mediated FGFR4 signaling R-HSA-5654712 Downstream signaling of activated FGFR4 R-HSA-5654716 Negative regulation of FGFR1 signaling R-HSA-5654726 Negative regulation of FGFR2 signaling R-HSA-5654727 Negative regulation of FGFR3 signaling R-HSA-5654732 Negative regulation of FGFR4 signaling R-HSA-5654733 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 RAF activation R-HSA-5673000 RAF/MAP kinase cascade R-HSA-5673001 MAP2K and MAPK activation R-HSA-5674135 Negative feedback regulation of MAPK pathway R-HSA-5674499 Negative regulation of MAPK pathway R-HSA-5675221 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 Interleukin receptor SHC signaling R-HSA-912526",nucleus GO:0005634 IEA cytoplasm GO:0005737 IDA mitochondrion GO:0005739 IEA cytosol GO:0005829 TAS plasma membrane GO:0005886 TAS neuron projection GO:0043005 IEA intracellular membrane-bounded organelle GO:0043231 IDA cell body GO:0044297 IEA,"MAPK cascade TAS GO:0000165 activation of MAPKK activity IEA GO:0000186 myeloid progenitor cell differentiation IEA GO:0002318 protein phosphorylation IDA 17563371 GO:0006468 visual learning IEA GO:0008542 organ morphogenesis TAS 9207797 GO:0009887 positive regulation of gene expression IMP 22065586 GO:0010628 negative regulation of fibroblast migration IEA GO:0010764 glucose transport IDA 23010278 GO:0015758 thyroid gland development IEA GO:0030878 positive regulation of peptidyl-serine phosphorylation IDA 19667065 GO:0033138 somatic stem cell population maintenance IEA GO:0035019 cellular response to drug IEA GO:0035690 regulation of cell proliferation IEA GO:0042127 negative regulation of apoptotic process IDA 19667065 GO:0043066 CD4-positive, alpha-beta T cell differentiation IEA GO:0043367 positive T cell selection IEA GO:0043368 response to peptide hormone IEA GO:0043434 negative regulation of neuron apoptotic process IEA GO:0043524 thymus development IEA GO:0048538 positive regulation of axon regeneration IEA GO:0048680 positive regulation of axonogenesis IEA GO:0050772 protein heterooligomerization IEA GO:0051291 positive regulation of stress fiber assembly IEA GO:0051496 response to cAMP IEA GO:0051591 long-term synaptic potentiation IEA GO:0060291 head morphogenesis IEA GO:0060323 face development IEA GO:0060324 positive regulation of ERK1 and ERK2 cascade IDA 22065586 GO:0070374 cellular response to calcium ion IDA 18567582 GO:0071277 establishment of protein localization to membrane IDA 23010278 GO:0090150 positive regulation of substrate adhesion-dependent cell spreading IEA GO:1900026 negative regulation of synaptic vesicle exocytosis IEA GO:2000301 negative regulation of endothelial cell apoptotic process IEA GO:2000352",protein kinase activity GO:0004672 IDA 17563371 protein serine/threonine kinase activity GO:0004674 IDA 19667065 MAP kinase kinase kinase activity GO:0004709 IEA calcium ion binding GO:0005509 IDA 18567582 protein binding GO:0005515 IPI 12620389 15161933 16810323 16888650 17380122 17563371 17979178 18567582 20141835 22169110 22510884 22939624 23153539 23680146 24255178 24746704 25155755 25241761 25600339 26496610 ATP binding GO:0005524 IEA small GTPase binding GO:0031267 NOT IPI 12194967 mitogen-activated protein kinase kinase binding GO:0031434 IEA identical protein binding GO:0042802 IPI 16858395 22169110 22510884 25155755 protein heterodimerization activity GO:0046982 IEA,hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04150 mTOR signaling pathway - Homo sapiens (human) hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04720 Long-term potentiation - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa04726 Serotonergic synapse - Homo sapiens (human) hsa04730 Long-term depression - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04910 Insulin signaling pathway - Homo sapiens (human) hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa05034 Alcoholism - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05210 Colorectal cancer - Homo sapiens (human) hsa05211 Renal cell carcinoma - Homo sapiens (human) hsa05212 Pancreatic cancer - Homo sapiens (human) hsa05213 Endometrial cancer - Homo sapiens (human) hsa05214 Glioma - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05216 Thyroid cancer - Homo sapiens (human) hsa05218 Melanoma - Homo sapiens (human) hsa05219 Bladder cancer - Homo sapiens (human) hsa05220 Chronic myeloid leukemia - Homo sapiens (human) hsa05221 Acute myeloid leukemia - Homo sapiens (human) hsa05223 Non-small cell lung cancer - Homo sapiens (human),chemicalprobes.org PF-477736,O14757,Serine/threonine-protein kinase Chk1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,1111,CHK1,Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Cell Cycle R-HSA-1640170 Activation of ATR in response to replication stress R-HSA-176187 G2/M DNA damage checkpoint R-HSA-69473 G2/M Checkpoints R-HSA-69481 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 p53-Independent DNA Damage Response R-HSA-69610 p53-Independent G1/S DNA damage checkpoint R-HSA-69613 G1/S DNA Damage Checkpoints R-HSA-69615 Cell Cycle Checkpoints R-HSA-69620 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035,"15149599 IDA GO:0000781 colocalizes_with chromosome, telomeric region ISS GO:0000785 chromatin 9382850 IDA GO:0000794 condensed nuclear chromosome 23580065 IDA GO:0005615 extracellular space 15311285 20932473 IDA GO:0005634 nucleus IDA GO:0005654 nucleoplasm TAS GO:0005654 nucleoplasm IEA GO:0005657 replication fork 15311285 IDA GO:0005813 centrosome TAS GO:0005829 cytosol IDA GO:0043231 intracellular membrane-bounded organelle",DNA damage checkpoint 16963448 GO:0000077 IDA DNA damage checkpoint 19716789 GO:0000077 IMP G2/M transition of mitotic cell cycle GO:0000086 IEA DNA replication GO:0006260 TAS DNA repair 19716789 GO:0006281 IMP cellular response to DNA damage stimulus 20932473 GO:0006974 IMP DNA damage induced protein phosphorylation 16963448 GO:0006975 IDA regulation of double-strand break repair via homologous recombination 15665856 GO:0010569 IDA regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage GO:0010767 ISS peptidyl-threonine phosphorylation 15665856 GO:0018107 IDA G2 DNA damage checkpoint 20932473 GO:0031572 IMP histone H3-T11 phosphorylation GO:0035407 IEA regulation of cell proliferation GO:0042127 IEA negative regulation of mitotic nuclear division 15311285 GO:0045839 IDA regulation of mitotic centrosome separation 15311285 GO:0046602 IDA chromatin-mediated maintenance of transcription GO:0048096 ISS cellular response to mechanical stimulus 19593445 GO:0071260 IEP replicative senescence 15149599 GO:0090399 NAS regulation of signal transduction by p53 class mediator GO:1901796 TAS regulation of histone H3-K9 acetylation GO:2000615 ISS,protein kinase activity IMP 22024163 GO:0004672 protein serine/threonine kinase activity IDA 16963448 GO:0004674 protein serine/threonine kinase activity TAS GO:0004674 protein binding IPI 11836499 15665856 15798197 16330544 16963448 17380128 19223857 19330022 19716789 20639859 20969866 22505024 22939624 25249323 GO:0005515 ATP binding IEA GO:0005524 kinase activity TAS GO:0016301 histone kinase activity (H3-T11 specific) IDA 18243098 GO:0035402,hsa04110 Cell cycle - Homo sapiens (human) hsa04115 p53 signaling pathway - Homo sapiens (human) hsa05166 HTLV-I infection - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human),chemicalprobes.org CCT241533,O96017,Serine/threonine-protein kinase Chk2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,11200,CHK2,R-HSA-1640170 Cell Cycle R-HSA-69473 G2/M DNA damage checkpoint R-HSA-69481 G2/M Checkpoints R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69610 p53-Independent DNA Damage Response R-HSA-69613 p53-Independent G1/S DNA damage checkpoint R-HSA-69615 G1/S DNA Damage Checkpoints R-HSA-69620 Cell Cycle Checkpoints,"chromosome, telomeric region GO:0000781 15149599 IDA colocalizes_with nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS Golgi apparatus GO:0005794 IDA PML body GO:0016605 12402044 IDA","DNA damage checkpoint TAS 9889122 10617473 GO:0000077 G2/M transition of mitotic cell cycle IMP 16481012 GO:0000086 replicative cell aging IMP 22851694 GO:0001302 positive regulation of protein phosphorylation IEA GO:0001934 double-strand break repair IMP 18317453 GO:0006302 transcription, DNA-templated IEA GO:0006351 regulation of transcription, DNA-templated IDA 12717439 GO:0006355 protein phosphorylation IDA 12717439 GO:0006468 cellular response to DNA damage stimulus IDA 24550317 GO:0006974 cellular response to DNA damage stimulus IMP 16481012 GO:0006974 cellular response to DNA damage stimulus TAS 9836640 9889122 GO:0006974 DNA damage induced protein phosphorylation IMP 11298456 GO:0006975 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS GO:0006977 intrinsic apoptotic signaling pathway in response to DNA damage IDA 12402044 GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage IMP 12717439 18644861 GO:0008630 response to gamma radiation IEA GO:0010332 peptidyl-serine phosphorylation IEA GO:0018105 cellular response to drug IEA GO:0035690 regulation of protein catabolic process IMP 17101782 GO:0042176 signal transduction in response to DNA damage IDA 14744935 GO:0042770 cellular protein catabolic process IMP 11298456 GO:0044257 positive regulation of transcription, DNA-templated IDA 17101782 GO:0045893 protein autophosphorylation IDA 16794575 18644861 GO:0046777 protein stabilization IDA 12717439 GO:0050821 cell division IEA GO:0051301 negative regulation of cell cycle arrest IEA GO:0071157 signal transduction involved in intra-S DNA damage checkpoint IMP 11298456 GO:0072428 mitotic spindle assembly IMP 20364141 GO:0090307 replicative senescence NAS 15149599 GO:0090399 regulation of signal transduction by p53 class mediator TAS GO:1901796 response to doxorubicin IEA GO:1902520 cellular response to bisphenol A IEA GO:1903926 negative regulation of DNA damage checkpoint IEA GO:2000002 positive regulation of anoikis IEA GO:2000210",GO:0004674 protein serine/threonine kinase activity 12717439 16794575 IDA GO:0004674 protein serine/threonine kinase activity 9836640 TAS GO:0005515 protein binding 11298456 12402044 12493754 15380617 17157788 17380128 17525332 18644861 18667510 18971944 21070773 23178491 24825908 25640309 IPI GO:0005524 ATP binding IEA GO:0019901 protein kinase binding 16481012 IPI GO:0031625 ubiquitin protein ligase binding 22266820 IPI GO:0042802 identical protein binding 16794575 18239682 IPI GO:0042803 protein homodimerization activity 16794575 IDA GO:0046872 metal ion binding IEA,Cell cycle - Homo sapiens (human) hsa04110 p53 signaling pathway - Homo sapiens (human) hsa04115 HTLV-I infection - Homo sapiens (human) hsa05166,chemicalprobes.org AZD2014,P42345,Serine/threonine-protein kinase mTOR,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2475,MTOR,R-HSA-109703 PKB-mediated events R-HSA-109704 PI3K Cascade R-HSA-112399 IRS-mediated signalling R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1280218 Adaptive Immune System R-HSA-1433557 Signaling by SCF-KIT R-HSA-162582 Signal Transduction R-HSA-1632852 Macroautophagy R-HSA-1643685 Disease R-HSA-165159 mTOR signalling R-HSA-166208 mTORC1-mediated signalling R-HSA-166520 Signalling by NGF R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-177929 Signaling by EGFR R-HSA-180292 GAB1 signalosome R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-190236 Signaling by FGFR R-HSA-194138 Signaling by VEGF R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-212436 Generic Transcription Pathway R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2262752 Cellular responses to stress R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-3371556 Cellular response to heat stress R-HSA-3371571 HSF1-dependent transactivation R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-388841 Costimulation by the CD28 family R-HSA-389356 CD28 co-stimulation R-HSA-389357 CD28 dependent PI3K/Akt signaling R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-5218920 VEGFR2 mediated vascular permeability R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5663202 Diseases of signal transduction R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer R-HSA-74160 Gene Expression R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-983705 Signaling by the B Cell Receptor (BCR),Golgi membrane GO:0000139 IEA nucleus GO:0005634 IBA nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 IDA 11853878 20381137 mitochondrial outer membrane GO:0005741 IEA lysosome GO:0005764 IDA 20381137 25936802 lysosomal membrane GO:0005765 IDA 17897319 endoplasmic reticulum membrane GO:0005789 IEA cytosol GO:0005829 TAS phosphatidylinositol 3-kinase complex GO:0005942 NAS 15539461 endomembrane system GO:0012505 IDA 18497260 membrane GO:0016020 IDA 11853878 19946888 PML body GO:0016605 colocalizes_with ISS dendrite GO:0030425 IEA TORC1 complex GO:0031931 IDA 12150926 15467718 18925875 TORC1 complex GO:0031931 IMP 20537536 TORC2 complex GO:0031932 IDA 15467718 18925875 neuronal cell body GO:0043025 IEA,IEA GO:0001933 negative regulation of protein phosphorylation 20233713 IDA GO:0001934 positive regulation of protein phosphorylation IEA GO:0001938 positive regulation of endothelial cell proliferation IEA GO:0003007 heart morphogenesis IEA GO:0003179 heart valve morphogenesis IEA GO:0005979 regulation of glycogen biosynthetic process IEA GO:0006112 energy reserve metabolic process IEA GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process IBA GO:0006281 DNA repair 12150926 15467718 18925875 IDA GO:0006468 protein phosphorylation 17028174 IMP GO:0006468 protein phosphorylation 17028174 IMP GO:0006950 response to stress TAS GO:0007050 cell cycle arrest 15539461 NAS GO:0007165 signal transduction IEA GO:0007281 germ cell development IEA GO:0007420 brain development IEA GO:0007569 cell aging 15539461 NAS GO:0007584 response to nutrient IEA GO:0007616 long-term memory IEA GO:0008542 visual learning IEA GO:0009791 post-embryonic development ISS GO:0010507 negative regulation of autophagy IEA GO:0010592 positive regulation of lamellipodium assembly 17028174 IMP GO:0010628 positive regulation of gene expression IEA GO:0010831 positive regulation of myotube differentiation IEA GO:0014042 positive regulation of neuron maturation IEA GO:0014736 negative regulation of muscle atrophy 18762023 IDA GO:0016049 cell growth 11853878 TAS GO:0016049 cell growth TAS GO:0016236 macroautophagy IEA GO:0016242 negative regulation of macroautophagy 11853878 IDA GO:0016310 phosphorylation 20537536 23728790 IMP GO:0018105 peptidyl-serine phosphorylation IEA GO:0018107 peptidyl-threonine phosphorylation IEA GO:0021510 spinal cord development 11853878 TAS GO:0030163 protein catabolic process IEA GO:0030838 positive regulation of actin filament polymerization TAS GO:0031295 T cell costimulation IEA GO:0031397 negative regulation of protein ubiquitination IEA GO:0031529 ruffle organization IEA GO:0031641 regulation of myelination ISS GO:0031669 cellular response to nutrient levels 15467718 17028174 18762023 IMP GO:0031929 TOR signaling IEA GO:0031998 regulation of fatty acid beta-oxidation IEA GO:0032095 regulation of response to food IEA GO:0032868 response to insulin 15467718 IMP GO:0032956 regulation of actin cytoskeleton organization IEA GO:0035176 social behavior IEA GO:0035264 multicellular organism growth 15539461 NAS GO:0040007 growth IEA GO:0042060 wound healing IEA GO:0042220 response to cocaine IEA GO:0043087 regulation of GTPase activity 18497260 IDA GO:0043200 response to amino acid IEA GO:0043278 response to morphine IEA GO:0043610 regulation of carbohydrate utilization IEA GO:0045429 positive regulation of nitric oxide biosynthetic process ISS GO:0045670 regulation of osteoclast differentiation 18762023 IDA GO:0045727 positive regulation of translation IEA GO:0045792 negative regulation of cell size IEA GO:0045859 regulation of protein kinase activity 20233713 IMP GO:0045945 positive regulation of transcription from RNA polymerase III promoter 15467718 IDA GO:0046777 protein autophosphorylation 18762023 IMP GO:0046889 positive regulation of lipid biosynthetic process TAS GO:0048015 phosphatidylinositol-mediated signaling IEA GO:0048255 mRNA stabilization IEA GO:0048661 positive regulation of smooth muscle cell proliferation IEA GO:0048714 positive regulation of oligodendrocyte differentiation IEA GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA GO:0050882 voluntary musculoskeletal movement IEA GO:0051496 positive regulation of stress fiber assembly IEA GO:0051534 negative regulation of NFAT protein import into nucleus IEA GO:0051897 positive regulation of protein kinase B signaling IEA GO:0055013 cardiac muscle cell development IEA GO:0060048 cardiac muscle contraction IEA GO:0060135 maternal process involved in female pregnancy IEA GO:0060252 positive regulation of glial cell proliferation IEA GO:0060999 positive regulation of dendritic spine development IEA GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development ISS GO:0071456 cellular response to hypoxia IEA GO:0090335 regulation of brown fat cell differentiation IEA GO:0090559 regulation of membrane permeability TAS GO:1900034 regulation of cellular response to heat IEA GO:1901216 positive regulation of neuron death 24036451 IMP GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter IEA GO:1904000 positive regulation of eating behavior IEA GO:1904056 positive regulation of cholangiocyte proliferation IEA GO:1904058 positive regulation of sensory perception of pain IEA GO:1904193 negative regulation of cholangiocyte apoptotic process IEA GO:1904197 positive regulation of granulosa cell proliferation IEA GO:1904206 positive regulation of skeletal muscle hypertrophy IEA GO:1904213 negative regulation of iodide transmembrane transport,RNA polymerase III type 1 promoter DNA binding 20233713 GO:0001030 IDA RNA polymerase III type 2 promoter DNA binding 20233713 GO:0001031 IDA RNA polymerase III type 3 promoter DNA binding 20233713 GO:0001032 IDA TFIIIC-class transcription factor binding 20543138 GO:0001156 IDA protein kinase activity 12150926 GO:0004672 IDA protein serine/threonine kinase activity 22768106 GO:0004674 EXP protein serine/threonine kinase activity 15467718 GO:0004674 IDA protein serine/threonine kinase activity GO:0004674 TAS protein binding 10089303 11438723 12150925 12150926 12408816 15467718 16915281 17461779 17565979 18339839 18566587 19446321 19619545 19875983 20562859 20864032 21045808 21376236 21471201 22424946 22664266 23027611 23394946 23953116 24036451 24375676 25241761 25446900 25657994 26787466 GO:0005515 IPI ATP binding GO:0005524 IEA kinase activity 15467718 GO:0016301 IDA kinase activity 11853878 GO:0016301 TAS protein kinase binding GO:0019901 IEA protein domain specific binding GO:0019904 IEA ribosome binding GO:0043022 IEA phosphoprotein binding 11853878 GO:0051219 IPI,hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04150 mTOR signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04152 AMPK signaling pathway - Homo sapiens (human) hsa04910 Insulin signaling pathway - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) hsa04930 Type II diabetes mellitus - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05214 Glioma - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05221 Acute myeloid leukemia - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human) hsa05231 Choline metabolism in cancer - Homo sapiens (human),chemicalprobes.org Rapamycin,P42345,Serine/threonine-protein kinase mTOR,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2475,MTOR,R-HSA-109703 PKB-mediated events R-HSA-109704 PI3K Cascade R-HSA-112399 IRS-mediated signalling R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1280218 Adaptive Immune System R-HSA-1433557 Signaling by SCF-KIT R-HSA-162582 Signal Transduction R-HSA-1632852 Macroautophagy R-HSA-1643685 Disease R-HSA-165159 mTOR signalling R-HSA-166208 mTORC1-mediated signalling R-HSA-166520 Signalling by NGF R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-177929 Signaling by EGFR R-HSA-180292 GAB1 signalosome R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-190236 Signaling by FGFR R-HSA-194138 Signaling by VEGF R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-212436 Generic Transcription Pathway R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2262752 Cellular responses to stress R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-3371556 Cellular response to heat stress R-HSA-3371571 HSF1-dependent transactivation R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-388841 Costimulation by the CD28 family R-HSA-389356 CD28 co-stimulation R-HSA-389357 CD28 dependent PI3K/Akt signaling R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-5218920 VEGFR2 mediated vascular permeability R-HSA-5628897 TP53 Regulates Metabolic Genes R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5663202 Diseases of signal transduction R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer R-HSA-74160 Gene Expression R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-983705 Signaling by the B Cell Receptor (BCR),Golgi membrane GO:0000139 IEA nucleus GO:0005634 IBA nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 IDA 11853878 20381137 mitochondrial outer membrane GO:0005741 IEA lysosome GO:0005764 IDA 20381137 25936802 lysosomal membrane GO:0005765 IDA 17897319 endoplasmic reticulum membrane GO:0005789 IEA cytosol GO:0005829 TAS phosphatidylinositol 3-kinase complex GO:0005942 NAS 15539461 endomembrane system GO:0012505 IDA 18497260 membrane GO:0016020 IDA 11853878 19946888 PML body GO:0016605 colocalizes_with ISS dendrite GO:0030425 IEA TORC1 complex GO:0031931 IDA 12150926 15467718 18925875 TORC1 complex GO:0031931 IMP 20537536 TORC2 complex GO:0031932 IDA 15467718 18925875 neuronal cell body GO:0043025 IEA,IEA GO:0001933 negative regulation of protein phosphorylation 20233713 IDA GO:0001934 positive regulation of protein phosphorylation IEA GO:0001938 positive regulation of endothelial cell proliferation IEA GO:0003007 heart morphogenesis IEA GO:0003179 heart valve morphogenesis IEA GO:0005979 regulation of glycogen biosynthetic process IEA GO:0006112 energy reserve metabolic process IEA GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process IBA GO:0006281 DNA repair 12150926 15467718 18925875 IDA GO:0006468 protein phosphorylation 17028174 IMP GO:0006468 protein phosphorylation 17028174 IMP GO:0006950 response to stress TAS GO:0007050 cell cycle arrest 15539461 NAS GO:0007165 signal transduction IEA GO:0007281 germ cell development IEA GO:0007420 brain development IEA GO:0007569 cell aging 15539461 NAS GO:0007584 response to nutrient IEA GO:0007616 long-term memory IEA GO:0008542 visual learning IEA GO:0009791 post-embryonic development ISS GO:0010507 negative regulation of autophagy IEA GO:0010592 positive regulation of lamellipodium assembly 17028174 IMP GO:0010628 positive regulation of gene expression IEA GO:0010831 positive regulation of myotube differentiation IEA GO:0014042 positive regulation of neuron maturation IEA GO:0014736 negative regulation of muscle atrophy 18762023 IDA GO:0016049 cell growth 11853878 TAS GO:0016049 cell growth TAS GO:0016236 macroautophagy IEA GO:0016242 negative regulation of macroautophagy 11853878 IDA GO:0016310 phosphorylation 20537536 23728790 IMP GO:0018105 peptidyl-serine phosphorylation IEA GO:0018107 peptidyl-threonine phosphorylation IEA GO:0021510 spinal cord development 11853878 TAS GO:0030163 protein catabolic process IEA GO:0030838 positive regulation of actin filament polymerization TAS GO:0031295 T cell costimulation IEA GO:0031397 negative regulation of protein ubiquitination IEA GO:0031529 ruffle organization IEA GO:0031641 regulation of myelination ISS GO:0031669 cellular response to nutrient levels 15467718 17028174 18762023 IMP GO:0031929 TOR signaling IEA GO:0031998 regulation of fatty acid beta-oxidation IEA GO:0032095 regulation of response to food IEA GO:0032868 response to insulin 15467718 IMP GO:0032956 regulation of actin cytoskeleton organization IEA GO:0035176 social behavior IEA GO:0035264 multicellular organism growth 15539461 NAS GO:0040007 growth IEA GO:0042060 wound healing IEA GO:0042220 response to cocaine IEA GO:0043087 regulation of GTPase activity 18497260 IDA GO:0043200 response to amino acid IEA GO:0043278 response to morphine IEA GO:0043610 regulation of carbohydrate utilization IEA GO:0045429 positive regulation of nitric oxide biosynthetic process ISS GO:0045670 regulation of osteoclast differentiation 18762023 IDA GO:0045727 positive regulation of translation IEA GO:0045792 negative regulation of cell size IEA GO:0045859 regulation of protein kinase activity 20233713 IMP GO:0045945 positive regulation of transcription from RNA polymerase III promoter 15467718 IDA GO:0046777 protein autophosphorylation 18762023 IMP GO:0046889 positive regulation of lipid biosynthetic process TAS GO:0048015 phosphatidylinositol-mediated signaling IEA GO:0048255 mRNA stabilization IEA GO:0048661 positive regulation of smooth muscle cell proliferation IEA GO:0048714 positive regulation of oligodendrocyte differentiation IEA GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA GO:0050882 voluntary musculoskeletal movement IEA GO:0051496 positive regulation of stress fiber assembly IEA GO:0051534 negative regulation of NFAT protein import into nucleus IEA GO:0051897 positive regulation of protein kinase B signaling IEA GO:0055013 cardiac muscle cell development IEA GO:0060048 cardiac muscle contraction IEA GO:0060135 maternal process involved in female pregnancy IEA GO:0060252 positive regulation of glial cell proliferation IEA GO:0060999 positive regulation of dendritic spine development IEA GO:0061051 positive regulation of cell growth involved in cardiac muscle cell development ISS GO:0071456 cellular response to hypoxia IEA GO:0090335 regulation of brown fat cell differentiation IEA GO:0090559 regulation of membrane permeability TAS GO:1900034 regulation of cellular response to heat IEA GO:1901216 positive regulation of neuron death 24036451 IMP GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter IEA GO:1904000 positive regulation of eating behavior IEA GO:1904056 positive regulation of cholangiocyte proliferation IEA GO:1904058 positive regulation of sensory perception of pain IEA GO:1904193 negative regulation of cholangiocyte apoptotic process IEA GO:1904197 positive regulation of granulosa cell proliferation IEA GO:1904206 positive regulation of skeletal muscle hypertrophy IEA GO:1904213 negative regulation of iodide transmembrane transport,RNA polymerase III type 1 promoter DNA binding 20233713 GO:0001030 IDA RNA polymerase III type 2 promoter DNA binding 20233713 GO:0001031 IDA RNA polymerase III type 3 promoter DNA binding 20233713 GO:0001032 IDA TFIIIC-class transcription factor binding 20543138 GO:0001156 IDA protein kinase activity 12150926 GO:0004672 IDA protein serine/threonine kinase activity 22768106 GO:0004674 EXP protein serine/threonine kinase activity 15467718 GO:0004674 IDA protein serine/threonine kinase activity GO:0004674 TAS protein binding 10089303 11438723 12150925 12150926 12408816 15467718 16915281 17461779 17565979 18339839 18566587 19446321 19619545 19875983 20562859 20864032 21045808 21376236 21471201 22424946 22664266 23027611 23394946 23953116 24036451 24375676 25241761 25446900 25657994 26787466 GO:0005515 IPI ATP binding GO:0005524 IEA kinase activity 15467718 GO:0016301 IDA kinase activity 11853878 GO:0016301 TAS protein kinase binding GO:0019901 IEA protein domain specific binding GO:0019904 IEA ribosome binding GO:0043022 IEA phosphoprotein binding 11853878 GO:0051219 IPI,hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04150 mTOR signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04152 AMPK signaling pathway - Homo sapiens (human) hsa04910 Insulin signaling pathway - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) hsa04930 Type II diabetes mellitus - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05214 Glioma - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05221 Acute myeloid leukemia - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human) hsa05231 Choline metabolism in cancer - Homo sapiens (human),chemicalprobes.org PF-3758309,Q13153,Serine/threonine-protein kinase PAK 1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,5058,PAK1,Developmental Biology R-HSA-1266738 Adaptive Immune System R-HSA-1280218 Cell-Cell communication R-HSA-1500931 Signal Transduction R-HSA-162582 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Signaling by VEGF R-HSA-194138 Signaling by Rho GTPases R-HSA-194315 RHO GTPase Effectors R-HSA-195258 TCR signaling R-HSA-202403 Generation of second messenger molecules R-HSA-202433 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 Regulation of actin dynamics for phagocytic cup formation R-HSA-2029482 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 EPH-Ephrin signaling R-HSA-2682334 FCERI mediated MAPK activation R-HSA-2871796 Semaphorin interactions R-HSA-373755 L1CAM interactions R-HSA-373760 DSCAM interactions R-HSA-376172 Signaling by Robo receptor R-HSA-376176 Costimulation by the CD28 family R-HSA-388841 CD28 co-stimulation R-HSA-389356 CD28 dependent Vav1 pathway R-HSA-389359 EPHB-mediated forward signaling R-HSA-3928662 Ephrin signaling R-HSA-3928664 Sema3A PAK dependent Axon repulsion R-HSA-399954 Axon guidance R-HSA-422475 Activation of Rac R-HSA-428540 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signal transduction by L1 R-HSA-445144 VEGFR2 mediated vascular permeability R-HSA-5218920 C-type lectin receptors (CLRs) R-HSA-5621481 CD209 (DC-SIGN) signaling R-HSA-5621575 RHO GTPases activate PAKs R-HSA-5627123 MAPK family signaling cascades R-HSA-5683057 MAPK6/MAPK4 signaling R-HSA-5687128,ruffle GO:0001726 IDA 12912914 cytoplasm GO:0005737 IDA 16278681 25766321 Golgi apparatus GO:0005794 IDA cytosol GO:0005829 TAS plasma membrane GO:0005886 IDA 16278681 plasma membrane GO:0005886 TAS cell-cell junction GO:0005911 IDA 12912914 focal adhesion GO:0005925 IEA intercalated disc GO:0014704 ISS Z disc GO:0030018 ISS axon GO:0030424 ISS dendrite GO:0030425 ISS filamentous actin GO:0031941 colocalizes_with NAS 9395435 nuclear membrane GO:0031965 ISS ruffle membrane GO:0032587 IEA protein complex GO:0043234 IDA 11864573 invadopodium GO:0071437 IDA 25766321,8805275 IDA GO:0000165 NOT MAPK cascade IBA GO:0000278 NOT mitotic cell cycle IEA GO:0001666 response to hypoxia 23633677 IMP GO:0001934 positive regulation of protein phosphorylation TAS GO:0002223 stimulatory C-type lectin receptor signaling pathway 9852149 IDA GO:0006468 protein phosphorylation IEA GO:0006887 exocytosis IEA GO:0006915 apoptotic process IBA GO:0007409 axonogenesis 25766321 IDA GO:0030335 positive regulation of cell migration TAS GO:0031295 T cell costimulation 9395435 IDA GO:0031532 actin cytoskeleton reorganization 16278681 IMP GO:0031532 actin cytoskeleton reorganization IEA GO:0032869 cellular response to insulin stimulus 19667065 IDA GO:0033138 positive regulation of peptidyl-serine phosphorylation 16278681 IDA GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway TAS GO:0038095 Fc-epsilon receptor signaling pathway TAS GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 12912914 IMP GO:0042060 wound healing 8805275 IMP GO:0043507 positive regulation of JUN kinase activity 8805275 IDA GO:0046777 protein autophosphorylation TAS GO:0048013 ephrin receptor signaling pathway 20457839 IMP GO:0048754 branching morphogenesis of an epithelial tube ISS GO:0048812 neuron projection morphogenesis TAS GO:0050852 T cell receptor signaling pathway 11864573 IMP GO:0051496 positive regulation of stress fiber assembly 12912914 IMP GO:0060244 negative regulation of cell proliferation involved in contact inhibition,protein kinase activity 8805275 9852149 GO:0004672 IDA protein serine/threonine kinase activity 10075701 10559936 11278486 17060906 GO:0004674 EXP protein serine/threonine kinase activity 16278681 19667065 GO:0004674 IDA protein serine/threonine kinase activity GO:0004674 TAS receptor signaling protein serine/threonine kinase activity GO:0004702 IBA protein binding 10026169 10559936 11030651 11864573 12606577 12624090 12879077 16101281 16278681 16407834 16413544 16492808 16628223 17245428 18325335 18716323 18854161 19270716 19596003 19732720 19893577 20810653 20936779 21029865 21167153 21454543 22117219 22581261 23455922 24625804 24792722 25416956 25766321 25843002 25852190 GO:0005515 IPI protein binding contributes_to 11950598 GO:0005515 IPI collagen binding 12189148 GO:0005518 IPI ATP binding GO:0005524 IEA protein kinase binding GO:0019901 IEA,MAPK signaling pathway - Homo sapiens (human) hsa04010 ErbB signaling pathway - Homo sapiens (human) hsa04012 Ras signaling pathway - Homo sapiens (human) hsa04014 cAMP signaling pathway - Homo sapiens (human) hsa04024 Chemokine signaling pathway - Homo sapiens (human) hsa04062 Axon guidance - Homo sapiens (human) hsa04360 Focal adhesion - Homo sapiens (human) hsa04510 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04650 T cell receptor signaling pathway - Homo sapiens (human) hsa04660 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04666 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04810 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) hsa05120 Proteoglycans in cancer - Homo sapiens (human) hsa05205 Renal cell carcinoma - Homo sapiens (human) hsa05211,chemicalprobes.org PF-3758309,O96013,Serine/threonine-protein kinase PAK 4,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10298,PAK4,R-HSA-1266738 Developmental Biology R-HSA-376176 Signaling by Robo receptor R-HSA-422475 Axon guidance R-HSA-428540 Activation of Rac,TAS 9822598 Golgi apparatus GO:0005794 IDA 21423176 focal adhesion GO:0005925,mitotic cell cycle GO:0000278 IBA NOT apoptotic process GO:0006915 20070256 TAS movement of cell or subcellular component GO:0006928 9822598 TAS cytoskeleton organization GO:0007010 20070256 TAS signal transduction GO:0007165 20070256 TAS cell proliferation GO:0008283 20070256 TAS cell growth GO:0016049 20070256 TAS cell migration GO:0016477 20070256 TAS signal transduction by protein phosphorylation GO:0023014 IEA dendritic spine development GO:0060996 IEA cellular response to organic cyclic compound GO:0071407 IEA,9822598 GO:0004672 protein kinase activity NAS GO:0004702 receptor signaling protein serine/threonine kinase activity IBA 20936779 21044950 22653441 25074804 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA,hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04360 Axon guidance - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04660 T cell receptor signaling pathway - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05211 Renal cell carcinoma - Homo sapiens (human),chemicalprobes.org PF-3758309,Q9NQU5,Serine/threonine-protein kinase PAK6,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,106821730,PAK6,,,,,,chemicalprobes.org PF-3758309,Q9P286,Serine/threonine-protein kinase PAK7,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,57144,PAK5,Developmental Biology R-HSA-1266738 Signaling by Robo receptor R-HSA-376176 Axon guidance R-HSA-422475 Activation of Rac R-HSA-428540,IEA GO:0005634 nucleus IBA GO:0005737 cytoplasm IEA GO:0005739 mitochondrion,mitotic cell cycle NOT GO:0000278 IBA apoptotic process 20070256 GO:0006915 TAS cytoskeleton organization 20070256 GO:0007010 TAS signal transduction 20070256 GO:0007165 TAS learning GO:0007612 IEA memory GO:0007613 IEA locomotory behavior GO:0007626 IEA cell proliferation 20070256 GO:0008283 TAS cell growth 20070256 GO:0016049 TAS cell migration 20070256 GO:0016477 TAS signal transduction by protein phosphorylation GO:0023014 IEA negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IEA,receptor signaling protein serine/threonine kinase activity IBA GO:0004702 ATP binding IEA GO:0005524,ErbB signaling pathway - Homo sapiens (human) hsa04012 Ras signaling pathway - Homo sapiens (human) hsa04014 Axon guidance - Homo sapiens (human) hsa04360 Focal adhesion - Homo sapiens (human) hsa04510 T cell receptor signaling pathway - Homo sapiens (human) hsa04660 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04810 Renal cell carcinoma - Homo sapiens (human) hsa05211,chemicalprobes.org BI2536,P53350,Serine/threonine-protein kinase PLK1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,5347,PLK1,"Polo-like kinase mediated events R-HSA-156711 Signal Transduction R-HSA-162582 Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 Cell Cycle R-HSA-1640170 APC/C-mediated degradation of cell cycle proteins R-HSA-174143 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 Phosphorylation of the APC/C R-HSA-176412 Phosphorylation of Emi1 R-HSA-176417 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 Organelle biogenesis and maintenance R-HSA-1852241 Signaling by Rho GTPases R-HSA-194315 RHO GTPase Effectors R-HSA-195258 Condensation of Prophase Chromosomes R-HSA-2299718 Separation of Sister Chromatids R-HSA-2467813 Resolution of Sister Chromatid Cohesion R-HSA-2500257 Mitotic Metaphase and Anaphase R-HSA-2555396 Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 Nuclear Envelope Breakdown R-HSA-2980766 Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 Loss of Nlp from mitotic centrosomes R-HSA-380259 Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 Loss of proteins required for interphase microtubule organizationfrom the centrosome R-HSA-380284 Centrosome maturation R-HSA-380287 Mitotic G2-G2/M phases R-HSA-453274 Regulation of mitotic cell cycle R-HSA-453276 Assembly of the primary cilium R-HSA-5617833 Anchoring of the basal body to the plasma membrane R-HSA-5620912 RHO GTPases Activate Formins R-HSA-5663220 Mitotic Prophase R-HSA-68875 Mitotic Prometaphase R-HSA-68877 Mitotic Metaphase/Anaphase Transition R-HSA-68881 Mitotic Anaphase R-HSA-68882 Mitotic Telophase/Cytokinesis R-HSA-68884 M Phase R-HSA-68886 Cyclin A/B1 associated events during G2/M transition R-HSA-69273 G2/M Transition R-HSA-69275 Cell Cycle, Mitotic R-HSA-69278",GO:0000776 kinetochore 17617734 18477460 18615013 21041660 23455478 IDA GO:0000785 chromatin IEA GO:0000795 synaptonemal complex IEA GO:0000922 spindle pole 18331714 21041660 IDA GO:0000942 condensed nuclear chromosome outer kinetochore 18195732 IDA GO:0005634 nucleus 18615013 IDA GO:0005654 nucleoplasm TAS GO:0005730 nucleolus IDA GO:0005737 cytoplasm IDA GO:0005813 centrosome 8991084 12524548 18477460 18615013 21041660 21399614 23455478 IDA GO:0005819 spindle 12939256 17351640 IDA GO:0005829 cytosol TAS GO:0005876 spindle microtubule colocalizes_with 21041660 IDA GO:0015630 microtubule cytoskeleton 21041660 IDA GO:0030496 midbody 19468300 IDA GO:0051233 spindle midzone 19468302 21041660 IDA,mitotic sister chromatid segregation GO:0000070 23455478 IMP G2/M transition of mitotic cell cycle GO:0000086 19160488 IDA G2/M transition of mitotic cell cycle GO:0000086 TAS negative regulation of transcription from RNA polymerase II promoter GO:0000122 18174154 IMP mitotic cytokinesis GO:0000281 19468302 IDA cytokinesis GO:0000910 17351640 IDA cytokinesis GO:0000910 12939256 IMP microtubule bundle formation GO:0001578 12939256 IDA protein phosphorylation GO:0006468 19468300 22701722 IDA sister chromatid cohesion GO:0007062 TAS mitotic nuclear division GO:0007067 18615013 IDA mitotic nuclear division GO:0007067 18477460 IMP mitotic nuclear envelope disassembly GO:0007077 TAS mitotic spindle assembly checkpoint GO:0007094 23455478 IMP regulation of mitotic cell cycle GO:0007346 17495026 IMP cell proliferation GO:0008283 8127874 TAS positive regulation of peptidyl-threonine phosphorylation GO:0010800 21041660 IMP female meiosis chromosome segregation GO:0016321 IEA protein ubiquitination GO:0016567 16885022 IDA peptidyl-serine phosphorylation GO:0018105 16885022 IDA regulation of mitotic metaphase/anaphase transition GO:0030071 21041660 IMP anaphase-promoting complex-dependent catabolic process GO:0031145 TAS G2 DNA damage checkpoint GO:0031572 18662541 IDA protein destabilization GO:0031648 16885022 IDA positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 19473992 IMP protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 TAS negative regulation of apoptotic process GO:0043066 18174154 IMP regulation of protein binding GO:0043393 21041660 IMP homologous chromosome segregation GO:0045143 IEA establishment of protein localization GO:0045184 18331714 IMP negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 21041660 IMP positive regulation of proteolysis GO:0045862 16885022 IDA centrosome organization GO:0051297 8991084 18477460 IMP positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0051437 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051439 TAS positive regulation of ubiquitin-protein transferase activity GO:0051443 19473992 IMP regulation of cell cycle GO:0051726 TAS synaptonemal complex disassembly GO:0070194 IEA protein localization to chromatin GO:0071168 21111234 IDA positive regulation of protein localization to nucleus GO:1900182 TAS regulation of mitotic spindle assembly GO:1901673 22621898 IDA regulation of cell cycle G2/M phase transition GO:1902749 TAS positive regulation of ubiquitin protein ligase activity GO:1904668 15148369 IDA,protein kinase activity GO:0004672 17146433 19596235 22854038 IDA protein serine/threonine kinase activity GO:0004674 18378770 20577264 EXP protein serine/threonine kinase activity GO:0004674 12524548 12939256 15148369 17351640 18174154 18477460 19160488 19468300 19468302 IDA protein serine/threonine kinase activity GO:0004674 19473992 21041660 23455478 IMP protein serine/threonine kinase activity GO:0004674 TAS protein binding GO:0005515 12493754 12524548 12939256 15148369 15654075 16439210 16753148 16760428 16980960 17146433 17310276 17351640 17495026 18174154 18329369 18331714 18477460 18521620 18615013 19160488 19468300 19468302 19473992 19596235 19833129 20360068 20534861 20577264 20890306 21642957 21887822 21988832 22609948 22653443 23455478 25852190 26496610 26638075 IPI ATP binding GO:0005524 IEA microtubule binding GO:0008017 12939256 IDA anaphase-promoting complex binding GO:0010997 18662541 IPI kinase activity GO:0016301 TAS protein kinase binding GO:0019901 12639966 18615013 21041660 IPI,hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04110 Cell cycle - Homo sapiens (human) hsa04114 Oocyte meiosis - Homo sapiens (human) hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human),chemicalprobes.org BI2536,Q9NYY3,Serine/threonine-protein kinase PLK2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10769,PLK2,,chromatin GO:0000785 IEA intracellular GO:0005622 ISS cytoplasm GO:0005737 IDA 23983262 centrosome GO:0005813 IDA 15242618 centriole GO:0005814 IDA 19001868 cytosol GO:0005829 TAS dendrite GO:0030425 ISS,"G1/S transition of mitotic cell cycle 15242618 GO:0000082 IMP protein phosphorylation 20352051 GO:0006468 IDA DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 TAS mitotic spindle organization 19001868 GO:0007052 IDA mitotic cell cycle checkpoint GO:0007093 ISS Ras protein signal transduction GO:0007265 ISS memory GO:0007613 ISS positive regulation of autophagy 23983262 GO:0010508 IDA peptidyl-serine phosphorylation 23983262 GO:0018105 IDA positive regulation of protein binding GO:0032092 IEA positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IEA Rap protein signal transduction GO:0032486 ISS negative regulation of apoptotic process GO:0043066 ISS positive regulation of I-kappaB kinase/NF-kappaB signaling 12761501 GO:0043123 IMP positive regulation of protein catabolic process 23983262 GO:0045732 IDA regulation of centriole replication 19001868 20352051 20531387 GO:0046599 IDA regulation of centriole replication 15242618 GO:0046599 IMP regulation of synaptic plasticity GO:0048167 ISS long-term synaptic potentiation GO:0060291 ISS long term synaptic depression GO:0060292 ISS negative regulation of dendritic spine development GO:0061000 IEA",protein serine/threonine kinase activity 19001868 20352051 20531387 23983262 GO:0004674 IDA protein serine/threonine kinase activity GO:0004674 TAS signal transducer activity 12761501 GO:0004871 IMP protein binding 20352051 20531387 25416956 GO:0005515 IPI ATP binding GO:0005524 IEA protein complex binding GO:0032403 IEA ATP-dependent protein binding 23983262 GO:0043008 IDA,FoxO signaling pathway - Homo sapiens (human) hsa04068,chemicalprobes.org BI2536,Q9H4B4,Serine/threonine-protein kinase PLK3,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,1263,PLK3,,IDA 19490146 21098032 nucleus GO:0005634 TAS GO:0005654 nucleoplasm IDA 17264206 nucleolus GO:0005730 IDA 19490146 cytoplasm GO:0005737 IDA 14980500 Golgi stack GO:0005795 IDA 16478733 20951827 centrosome GO:0005813 IEA GO:0030425 dendrite IEA GO:0043025 neuronal cell body,"17264206 GO:0000082 G1/S transition of mitotic cell cycle IMP 16481012 GO:0000086 G2/M transition of mitotic cell cycle TAS 19490146 GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 11447225 GO:0000302 response to reactive oxygen species IDA GO:0006468 protein phosphorylation IEA 16478733 GO:0006915 apoptotic process TAS 21098032 GO:0006970 response to osmotic stress IDA 19490146 GO:0006974 cellular response to DNA damage stimulus IDA 16481012 GO:0006974 cellular response to DNA damage stimulus IMP GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS 21840391 GO:0007093 mitotic cell cycle checkpoint TAS 21264284 GO:0007113 endomitotic cell cycle TAS 21376736 GO:0009314 response to radiation IDA 20951827 GO:0031122 cytoplasmic microtubule organization IMP 16478733 GO:0032465 regulation of cytokinesis IMP 21840391 GO:0032465 regulation of cytokinesis TAS 19490146 GO:0043066 negative regulation of apoptotic process IDA GO:0043491 protein kinase B signaling ISS GO:0044819 mitotic G1/S transition checkpoint ISS 20951827 GO:0051302 regulation of cell division IDA 14980500 19103756 GO:0090166 Golgi disassembly IDA 20951827 GO:0090316 positive regulation of intracellular protein transport IMP GO:1901796 regulation of signal transduction by p53 class mediator TAS 20889502 GO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia IDA",11447225 GO:0002039 p53 binding IDA 11447225 14968113 16481012 19103756 20889502 21098032 21376736 21840391 GO:0004674 protein serine/threonine kinase activity IDA GO:0004674 protein serine/threonine kinase activity TAS 14968113 14980500 16481012 18482256 19103756 19490146 20889502 20951827 21098032 21264284 21376736 21840391 25416956 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA,hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa05152 Tuberculosis - Homo sapiens (human),chemicalprobes.org CFI-400945,O00444,Serine/threonine-protein kinase PLK4,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,10733,PLK4,"R-HSA-1640170 Cell Cycle R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition R-HSA-380259 Loss of Nlp from mitotic centrosomes R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes R-HSA-380284 Loss of proteins required for interphase microtubule organizationfrom the centrosome R-HSA-380287 Centrosome maturation R-HSA-453274 Mitotic G2-G2/M phases R-HSA-5617833 Assembly of the primary cilium R-HSA-5620912 Anchoring of the basal body to the plasma membrane R-HSA-69275 G2/M Transition R-HSA-69278 Cell Cycle, Mitotic",XY body GO:0001741 IEA nucleolus GO:0005730 ISS centrosome GO:0005813 21399614 IDA centriole GO:0005814 16244668 17681131 IDA cytosol GO:0005829 TAS cleavage furrow GO:0032154 IEA deuterosome GO:0098536 ISS,GO:0000086 G2/M transition of mitotic cell cycle TAS GO:0006468 protein phosphorylation IEA GO:0007099 centriole replication 21725316 IMP GO:0046601 positive regulation of centriole replication 22349705 IDA GO:0046601 positive regulation of centriole replication 16244668 17681131 IMP GO:0060707 trophoblast giant cell differentiation ISS GO:0098535 de novo centriole assembly ISS,GO:0004674 protein serine/threonine kinase activity 21725316 IDA GO:0004674 protein serine/threonine kinase activity ISS GO:0005515 protein binding 16189514 20852615 21059844 21725316 25416956 IPI GO:0005524 ATP binding IEA GO:0042802 identical protein binding IEA,FoxO signaling pathway - Homo sapiens (human) hsa04068,chemicalprobes.org HG-9-91-01,P57059,Serine/threonine-protein kinase SIK1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,102724428,SIK1,,,,,,chemicalprobes.org HG-9-91-01,Q9H0K1,Serine/threonine-protein kinase SIK2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,23235,SIK2,,IBA GO:0005634 nucleus IBA GO:0005737 cytoplasm ISS GO:0005737 cytoplasm,GO:0006468 protein phosphorylation 14976552 IDA GO:0032870 cellular response to hormone stimulus IBA GO:0035556 intracellular signal transduction 14976552 IDA GO:0046626 regulation of insulin receptor signaling pathway ISS GO:0046777 protein autophosphorylation 18348280 IDA,GO:0000287 magnesium ion binding 14976552 IDA GO:0004674 protein serine/threonine kinase activity 14976552 18348280 IDA GO:0005515 protein binding 20708153 25416956 IPI GO:0005524 ATP binding 14976552 IDA,hsa04922 Glucagon signaling pathway - Homo sapiens (human),chemicalprobes.org HG-9-91-01,Q9Y2K2,Serine/threonine-protein kinase SIK3,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,23387,SIK3,,cytoplasm GO:0005737 IEA,protein phosphorylation GO:0006468 IDA 14976552,magnesium ion binding GO:0000287 IDA 14976552 protein serine/threonine kinase activity GO:0004674 IDA 14976552 protein binding GO:0005515 IPI 16306228 ATP binding GO:0005524 IDA 14976552,,chemicalprobes.org Imatinib,P10721,Stem cell growth factor receptor,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,3815,KIT,"R-HSA-112399 IRS-mediated signalling R-HSA-112412 SOS-mediated signalling R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250196 SHC1 events in ERBB2 signaling R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1250347 SHC1 events in ERBB4 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1266738 Developmental Biology R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-1433557 Signaling by SCF-KIT R-HSA-1433559 Regulation of KIT signaling R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-166520 Signalling by NGF R-HSA-167044 Signalling to RAS R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-169893 Prolonged ERK activation events R-HSA-170968 Frs2-mediated activation R-HSA-170984 ARMS-mediated activation R-HSA-177929 Signaling by EGFR R-HSA-179812 GRB2 events in EGFR signaling R-HSA-180292 GAB1 signalosome R-HSA-180336 SHC1 events in EGFR signaling R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-187687 Signalling to ERKs R-HSA-187706 Signalling to p38 via RIT and RIN R-HSA-190236 Signaling by FGFR R-HSA-194138 Signaling by VEGF R-HSA-1963640 GRB2 events in ERBB2 signaling R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2586552 Signaling by Leptin R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-372790 Signaling by GPCR R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-422475 Axon guidance R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5663202 Diseases of signal transduction R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5683057 MAPK family signaling cascades R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-912526 Interleukin receptor SHC signaling R-HSA-983705 Signaling by the B Cell Receptor (BCR)",GO:0001669 acrosomal vesicle IEA 14625290 GO:0005615 extracellular space IDA GO:0005886 plasma membrane TAS GO:0005911 cell-cell junction IEA GO:0009897 external side of plasma membrane IEA GO:0009898 cytoplasmic side of plasma membrane IEA GO:0016021 integral component of membrane IEA GO:0042629 mast cell granule IEA,TAS GO:0000165 MAPK cascade 21640708 IDA GO:0000187 activation of MAPK activity ISS GO:0001541 ovarian follicle development IEA GO:0002318 myeloid progenitor cell differentiation IEA GO:0002320 lymphoid progenitor cell differentiation ISS GO:0002327 immature B cell differentiation ISS GO:0002371 dendritic cell cytokine production 20100931 IDA GO:0002551 mast cell chemotaxis IEA GO:0006687 glycosphingolipid metabolic process ISS GO:0006954 inflammatory response 9990072 TAS GO:0007165 signal transduction ISS GO:0007283 spermatogenesis 16129412 TAS GO:0007283 spermatogenesis IEA GO:0007286 spermatid development IEA GO:0008284 positive regulation of cell proliferation IEA GO:0008354 germ cell migration ISS GO:0008360 regulation of cell shape IEA GO:0008542 visual learning 17848411 IEP GO:0008584 male gonad development 16129412 TAS GO:0010863 positive regulation of phospholipase C activity TAS GO:0014066 regulation of phosphatidylinositol 3-kinase signaling 16129412 TAS GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 21640708 IDA GO:0018108 peptidyl-tyrosine phosphorylation 21640708 IDA GO:0019221 cytokine-mediated signaling pathway 21057534 TAS GO:0019827 stem cell population maintenance ISS GO:0030032 lamellipodium assembly 16129412 TAS GO:0030097 hemopoiesis ISS GO:0030217 T cell differentiation ISS GO:0030218 erythrocyte differentiation ISS GO:0030318 melanocyte differentiation 21057534 TAS GO:0030318 melanocyte differentiation IEA GO:0030335 positive regulation of cell migration IEA GO:0031274 positive regulation of pseudopodium assembly 1721869 IDA GO:0031532 actin cytoskeleton reorganization 20100931 IDA GO:0032762 mast cell cytokine production IEA GO:0035019 somatic stem cell population maintenance ISS GO:0035162 embryonic hemopoiesis IEA GO:0035234 ectopic germ cell programmed cell death IEA GO:0035701 hematopoietic stem cell migration ISS GO:0035855 megakaryocyte development 20100931 IDA GO:0038093 Fc receptor signaling pathway 17662946 IDA GO:0038109 Kit signaling pathway ISS GO:0038162 erythropoietin-mediated signaling pathway 16129412 21057534 TAS GO:0042127 regulation of cell proliferation 21135090 IMP GO:0042511 positive regulation of tyrosine phosphorylation of Stat1 protein 21135090 IMP GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein 21135090 IMP GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein IEA GO:0043069 negative regulation of programmed cell death 20100931 IMP GO:0043303 mast cell degranulation 21640708 IMP GO:0043410 positive regulation of MAPK cascade ISS GO:0043473 pigmentation IEA GO:0043547 positive regulation of GTPase activity 16129412 TAS GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA GO:0045747 positive regulation of Notch signaling pathway 21135090 IMP GO:0046427 positive regulation of JAK-STAT cascade 21640708 IDA GO:0046777 protein autophosphorylation IEA GO:0046854 phosphatidylinositol phosphorylation TAS GO:0048015 phosphatidylinositol-mediated signaling IEA GO:0048070 regulation of developmental pigmentation IEA GO:0048103 somatic stem cell division IEA GO:0048170 positive regulation of long-term neuronal synaptic plasticity ISS GO:0048565 digestive tract development ISS GO:0048863 stem cell differentiation IEA GO:0050673 epithelial cell proliferation ISS GO:0050910 detection of mechanical stimulus involved in sensory perception of sound 21135090 IMP GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity 1721869 IDA GO:0060326 cell chemotaxis ISS GO:0060374 mast cell differentiation 16129412 TAS GO:0060374 mast cell differentiation 21057534 TAS GO:0070662 mast cell proliferation IEA GO:0097067 cellular response to thyroid hormone stimulus ISS GO:0097324 melanocyte migration ISS GO:0097326 melanocyte adhesion 19088079 IDA GO:1905065 positive regulation of vascular smooth muscle cell differentiation,"IEA GO:0002020 protease binding 1717985 TAS GO:0004713 protein tyrosine kinase activity 21640708 IDA GO:0004714 transmembrane receptor protein tyrosine kinase activity IEA GO:0004716 receptor signaling protein tyrosine kinase activity IEA GO:0005020 stem cell factor receptor activity TAS GO:0005088 Ras guanyl-nucleotide exchange factor activity 1382595 7523381 7537096 10377264 10397721 11018522 12878163 17662946 24728074 25241761 IPI GO:0005515 protein binding IEA GO:0005524 ATP binding 21640708 IDA GO:0019955 cytokine binding 21640708 IPI GO:0042803 protein homodimerization activity IEA GO:0046872 metal ion binding TAS GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity",Ras signaling pathway - Homo sapiens (human) hsa04014 Rap1 signaling pathway - Homo sapiens (human) hsa04015 Cytokine-cytokine receptor interaction - Homo sapiens (human) hsa04060 Endocytosis - Homo sapiens (human) hsa04144 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Hematopoietic cell lineage - Homo sapiens (human) hsa04640 Melanogenesis - Homo sapiens (human) hsa04916 Pathways in cancer - Homo sapiens (human) hsa05200 Acute myeloid leukemia - Homo sapiens (human) hsa05221 Central carbon metabolism in cancer - Homo sapiens (human) hsa05230,chemicalprobes.org AZ6102,O95271,Tankyrase-1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,8658,TNKS1,"Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Signaling by Wnt R-HSA-195721 TCF dependent signaling in response to WNT R-HSA-201681 degradation of AXIN R-HSA-4641257 Signaling by WNT in cancer R-HSA-4791275 XAV939 inhibits tankyrase, stabilizing AXIN R-HSA-5545619 Diseases of signal transduction R-HSA-5663202","Golgi membrane GO:0000139 IEA pericentriolar material GO:0000242 11454873 TAS chromosome, centromeric region GO:0000775 IEA chromosome, telomeric region GO:0000781 9822378 IDA nuclear chromosome, telomeric region GO:0000784 9822378 11739745 IDA spindle pole GO:0000922 IEA nuclear pore GO:0005643 11454873 TAS Golgi apparatus GO:0005794 22864114 IDA cytosol GO:0005829 TAS nuclear membrane GO:0031965 11454873 TAS","protein polyubiquitination IDA 19759537 21478859 GO:0000209 protein ADP-ribosylation IDA 9822378 15133513 21270334 GO:0006471 mitotic spindle organization TAS 17026964 GO:0007052 mitotic nuclear division IEA GO:0007067 protein transport IEA GO:0015031 Wnt signaling pathway TAS GO:0016055 peptidyl-serine phosphorylation IDA 17026964 GO:0018105 peptidyl-threonine phosphorylation IDA 17026964 GO:0018107 regulation of telomere maintenance via telomerase IC 9822378 GO:0032210 positive regulation of telomere maintenance via telomerase IDA 12782650 18221737 GO:0032212 positive regulation of telomere maintenance via telomerase IMP 11739745 GO:0032212 positive regulation of transcription from RNA polymerase II promoter IDA 19245366 GO:0045944 mRNA transport IEA GO:0051028 spindle assembly TAS 17026964 GO:0051225 cell division IEA GO:0051301 positive regulation of telomerase activity IDA 12782650 GO:0051973 protein localization to chromosome, telomeric region IMP 15133513 18221737 GO:0070198 protein poly-ADP-ribosylation IDA 9822378 GO:0070212 protein poly-ADP-ribosylation IMP 25939383 GO:0070212 protein auto-ADP-ribosylation IDA 9822378 15133513 19759537 21478859 GO:0070213 positive regulation of canonical Wnt signaling pathway IMP 19759537 25939383 GO:0090263 positive regulation of canonical Wnt signaling pathway TAS GO:0090263 positive regulation of telomere capping IDA 21531765 GO:1904355 positive regulation of telomere capping IMP 25939383 GO:1904355 negative regulation of telomere maintenance via telomere lengthening IMP 25939383 GO:1904357 negative regulation of telomeric DNA binding IDA 9822378 GO:1904743 negative regulation of telomeric DNA binding IMP 25939383 GO:1904743 negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric IMP 26373281 GO:1904908",GO:0003950 NAD+ ADP-ribosyltransferase activity 9822378 19759537 21270334 21478859 22864114 IDA GO:0003950 NAD+ ADP-ribosyltransferase activity TAS GO:0005515 protein binding 9822378 12768206 14596906 15133513 19759537 20696165 21251231 21478859 22699936 22864114 26373281 26496610 IPI GO:0008270 zinc ion binding 18436240 IDA GO:0042393 histone binding 26373281 IPI,,chemicalprobes.org JW55,O95271,Tankyrase-1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,8658,TNKS1,"Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Signaling by Wnt R-HSA-195721 TCF dependent signaling in response to WNT R-HSA-201681 degradation of AXIN R-HSA-4641257 Signaling by WNT in cancer R-HSA-4791275 XAV939 inhibits tankyrase, stabilizing AXIN R-HSA-5545619 Diseases of signal transduction R-HSA-5663202","Golgi membrane GO:0000139 IEA pericentriolar material GO:0000242 11454873 TAS chromosome, centromeric region GO:0000775 IEA chromosome, telomeric region GO:0000781 9822378 IDA nuclear chromosome, telomeric region GO:0000784 9822378 11739745 IDA spindle pole GO:0000922 IEA nuclear pore GO:0005643 11454873 TAS Golgi apparatus GO:0005794 22864114 IDA cytosol GO:0005829 TAS nuclear membrane GO:0031965 11454873 TAS","protein polyubiquitination IDA 19759537 21478859 GO:0000209 protein ADP-ribosylation IDA 9822378 15133513 21270334 GO:0006471 mitotic spindle organization TAS 17026964 GO:0007052 mitotic nuclear division IEA GO:0007067 protein transport IEA GO:0015031 Wnt signaling pathway TAS GO:0016055 peptidyl-serine phosphorylation IDA 17026964 GO:0018105 peptidyl-threonine phosphorylation IDA 17026964 GO:0018107 regulation of telomere maintenance via telomerase IC 9822378 GO:0032210 positive regulation of telomere maintenance via telomerase IDA 12782650 18221737 GO:0032212 positive regulation of telomere maintenance via telomerase IMP 11739745 GO:0032212 positive regulation of transcription from RNA polymerase II promoter IDA 19245366 GO:0045944 mRNA transport IEA GO:0051028 spindle assembly TAS 17026964 GO:0051225 cell division IEA GO:0051301 positive regulation of telomerase activity IDA 12782650 GO:0051973 protein localization to chromosome, telomeric region IMP 15133513 18221737 GO:0070198 protein poly-ADP-ribosylation IDA 9822378 GO:0070212 protein poly-ADP-ribosylation IMP 25939383 GO:0070212 protein auto-ADP-ribosylation IDA 9822378 15133513 19759537 21478859 GO:0070213 positive regulation of canonical Wnt signaling pathway IMP 19759537 25939383 GO:0090263 positive regulation of canonical Wnt signaling pathway TAS GO:0090263 positive regulation of telomere capping IDA 21531765 GO:1904355 positive regulation of telomere capping IMP 25939383 GO:1904355 negative regulation of telomere maintenance via telomere lengthening IMP 25939383 GO:1904357 negative regulation of telomeric DNA binding IDA 9822378 GO:1904743 negative regulation of telomeric DNA binding IMP 25939383 GO:1904743 negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric IMP 26373281 GO:1904908",GO:0003950 NAD+ ADP-ribosyltransferase activity 9822378 19759537 21270334 21478859 22864114 IDA GO:0003950 NAD+ ADP-ribosyltransferase activity TAS GO:0005515 protein binding 9822378 12768206 14596906 15133513 19759537 20696165 21251231 21478859 22699936 22864114 26373281 26496610 IPI GO:0008270 zinc ion binding 18436240 IDA GO:0042393 histone binding 26373281 IPI,,chemicalprobes.org E7449,O95271,Tankyrase-1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,8658,TNKS1,"Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Signaling by Wnt R-HSA-195721 TCF dependent signaling in response to WNT R-HSA-201681 degradation of AXIN R-HSA-4641257 Signaling by WNT in cancer R-HSA-4791275 XAV939 inhibits tankyrase, stabilizing AXIN R-HSA-5545619 Diseases of signal transduction R-HSA-5663202","Golgi membrane GO:0000139 IEA pericentriolar material GO:0000242 11454873 TAS chromosome, centromeric region GO:0000775 IEA chromosome, telomeric region GO:0000781 9822378 IDA nuclear chromosome, telomeric region GO:0000784 9822378 11739745 IDA spindle pole GO:0000922 IEA nuclear pore GO:0005643 11454873 TAS Golgi apparatus GO:0005794 22864114 IDA cytosol GO:0005829 TAS nuclear membrane GO:0031965 11454873 TAS","protein polyubiquitination IDA 19759537 21478859 GO:0000209 protein ADP-ribosylation IDA 9822378 15133513 21270334 GO:0006471 mitotic spindle organization TAS 17026964 GO:0007052 mitotic nuclear division IEA GO:0007067 protein transport IEA GO:0015031 Wnt signaling pathway TAS GO:0016055 peptidyl-serine phosphorylation IDA 17026964 GO:0018105 peptidyl-threonine phosphorylation IDA 17026964 GO:0018107 regulation of telomere maintenance via telomerase IC 9822378 GO:0032210 positive regulation of telomere maintenance via telomerase IDA 12782650 18221737 GO:0032212 positive regulation of telomere maintenance via telomerase IMP 11739745 GO:0032212 positive regulation of transcription from RNA polymerase II promoter IDA 19245366 GO:0045944 mRNA transport IEA GO:0051028 spindle assembly TAS 17026964 GO:0051225 cell division IEA GO:0051301 positive regulation of telomerase activity IDA 12782650 GO:0051973 protein localization to chromosome, telomeric region IMP 15133513 18221737 GO:0070198 protein poly-ADP-ribosylation IDA 9822378 GO:0070212 protein poly-ADP-ribosylation IMP 25939383 GO:0070212 protein auto-ADP-ribosylation IDA 9822378 15133513 19759537 21478859 GO:0070213 positive regulation of canonical Wnt signaling pathway IMP 19759537 25939383 GO:0090263 positive regulation of canonical Wnt signaling pathway TAS GO:0090263 positive regulation of telomere capping IDA 21531765 GO:1904355 positive regulation of telomere capping IMP 25939383 GO:1904355 negative regulation of telomere maintenance via telomere lengthening IMP 25939383 GO:1904357 negative regulation of telomeric DNA binding IDA 9822378 GO:1904743 negative regulation of telomeric DNA binding IMP 25939383 GO:1904743 negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric IMP 26373281 GO:1904908",GO:0003950 NAD+ ADP-ribosyltransferase activity 9822378 19759537 21270334 21478859 22864114 IDA GO:0003950 NAD+ ADP-ribosyltransferase activity TAS GO:0005515 protein binding 9822378 12768206 14596906 15133513 19759537 20696165 21251231 21478859 22699936 22864114 26373281 26496610 IPI GO:0008270 zinc ion binding 18436240 IDA GO:0042393 histone binding 26373281 IPI,,chemicalprobes.org XAV939,O95271,Tankyrase-1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,8658,TNKS1,"Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Signaling by Wnt R-HSA-195721 TCF dependent signaling in response to WNT R-HSA-201681 degradation of AXIN R-HSA-4641257 Signaling by WNT in cancer R-HSA-4791275 XAV939 inhibits tankyrase, stabilizing AXIN R-HSA-5545619 Diseases of signal transduction R-HSA-5663202","Golgi membrane GO:0000139 IEA pericentriolar material GO:0000242 11454873 TAS chromosome, centromeric region GO:0000775 IEA chromosome, telomeric region GO:0000781 9822378 IDA nuclear chromosome, telomeric region GO:0000784 9822378 11739745 IDA spindle pole GO:0000922 IEA nuclear pore GO:0005643 11454873 TAS Golgi apparatus GO:0005794 22864114 IDA cytosol GO:0005829 TAS nuclear membrane GO:0031965 11454873 TAS","protein polyubiquitination IDA 19759537 21478859 GO:0000209 protein ADP-ribosylation IDA 9822378 15133513 21270334 GO:0006471 mitotic spindle organization TAS 17026964 GO:0007052 mitotic nuclear division IEA GO:0007067 protein transport IEA GO:0015031 Wnt signaling pathway TAS GO:0016055 peptidyl-serine phosphorylation IDA 17026964 GO:0018105 peptidyl-threonine phosphorylation IDA 17026964 GO:0018107 regulation of telomere maintenance via telomerase IC 9822378 GO:0032210 positive regulation of telomere maintenance via telomerase IDA 12782650 18221737 GO:0032212 positive regulation of telomere maintenance via telomerase IMP 11739745 GO:0032212 positive regulation of transcription from RNA polymerase II promoter IDA 19245366 GO:0045944 mRNA transport IEA GO:0051028 spindle assembly TAS 17026964 GO:0051225 cell division IEA GO:0051301 positive regulation of telomerase activity IDA 12782650 GO:0051973 protein localization to chromosome, telomeric region IMP 15133513 18221737 GO:0070198 protein poly-ADP-ribosylation IDA 9822378 GO:0070212 protein poly-ADP-ribosylation IMP 25939383 GO:0070212 protein auto-ADP-ribosylation IDA 9822378 15133513 19759537 21478859 GO:0070213 positive regulation of canonical Wnt signaling pathway IMP 19759537 25939383 GO:0090263 positive regulation of canonical Wnt signaling pathway TAS GO:0090263 positive regulation of telomere capping IDA 21531765 GO:1904355 positive regulation of telomere capping IMP 25939383 GO:1904355 negative regulation of telomere maintenance via telomere lengthening IMP 25939383 GO:1904357 negative regulation of telomeric DNA binding IDA 9822378 GO:1904743 negative regulation of telomeric DNA binding IMP 25939383 GO:1904743 negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric IMP 26373281 GO:1904908",GO:0003950 NAD+ ADP-ribosyltransferase activity 9822378 19759537 21270334 21478859 22864114 IDA GO:0003950 NAD+ ADP-ribosyltransferase activity TAS GO:0005515 protein binding 9822378 12768206 14596906 15133513 19759537 20696165 21251231 21478859 22699936 22864114 26373281 26496610 IPI GO:0008270 zinc ion binding 18436240 IDA GO:0042393 histone binding 26373281 IPI,,chemicalprobes.org AZ6102,Q9H2K2,Tankyrase-2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,80351,TNKS2,"Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Signaling by Wnt R-HSA-195721 TCF dependent signaling in response to WNT R-HSA-201681 degradation of AXIN R-HSA-4641257 Signaling by WNT in cancer R-HSA-4791275 XAV939 inhibits tankyrase, stabilizing AXIN R-HSA-5545619 Diseases of signal transduction R-HSA-5663202","Golgi membrane GO:0000139 IEA pericentriolar material 11454873 GO:0000242 IDA nuclear chromosome, telomeric region 11739745 GO:0000784 IC nucleus 11739745 GO:0005634 IDA nuclear envelope 11454873 GO:0005635 IDA cytoplasm 11278563 GO:0005737 IDA cytosol GO:0005829 TAS perinuclear region of cytoplasm 11454873 GO:0048471 IDA","GO:0000209 protein polyubiquitination 19759537 21478859 IDA GO:0006471 protein ADP-ribosylation 11739745 IDA GO:0016055 Wnt signaling pathway TAS GO:0032212 positive regulation of telomere maintenance via telomerase 11739745 IC GO:0035264 multicellular organism growth IEA GO:0040014 regulation of multicellular organism growth IEA GO:0070198 protein localization to chromosome, telomeric region 11739745 IMP GO:0070213 protein auto-ADP-ribosylation 19759537 21478859 IDA GO:0090263 positive regulation of canonical Wnt signaling pathway 19759537 25939383 IMP GO:0090263 positive regulation of canonical Wnt signaling pathway TAS GO:1904355 positive regulation of telomere capping 21531765 IDA GO:1904355 positive regulation of telomere capping 25939383 IMP GO:1904357 negative regulation of telomere maintenance via telomere lengthening 25939383 IMP",NAD+ ADP-ribosyltransferase activity GO:0003950 IDA 11739745 19759537 21478859 NAD+ ADP-ribosyltransferase activity GO:0003950 TAS protein binding GO:0005515 IPI 19759537 21251231 21478859 22153076 22153077 23414517 enzyme binding GO:0019899 IPI 21251231 metal ion binding GO:0046872 IEA,,chemicalprobes.org JW55,Q9H2K2,Tankyrase-2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,80351,TNKS2,"Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Signaling by Wnt R-HSA-195721 TCF dependent signaling in response to WNT R-HSA-201681 degradation of AXIN R-HSA-4641257 Signaling by WNT in cancer R-HSA-4791275 XAV939 inhibits tankyrase, stabilizing AXIN R-HSA-5545619 Diseases of signal transduction R-HSA-5663202","Golgi membrane GO:0000139 IEA pericentriolar material 11454873 GO:0000242 IDA nuclear chromosome, telomeric region 11739745 GO:0000784 IC nucleus 11739745 GO:0005634 IDA nuclear envelope 11454873 GO:0005635 IDA cytoplasm 11278563 GO:0005737 IDA cytosol GO:0005829 TAS perinuclear region of cytoplasm 11454873 GO:0048471 IDA","GO:0000209 protein polyubiquitination 19759537 21478859 IDA GO:0006471 protein ADP-ribosylation 11739745 IDA GO:0016055 Wnt signaling pathway TAS GO:0032212 positive regulation of telomere maintenance via telomerase 11739745 IC GO:0035264 multicellular organism growth IEA GO:0040014 regulation of multicellular organism growth IEA GO:0070198 protein localization to chromosome, telomeric region 11739745 IMP GO:0070213 protein auto-ADP-ribosylation 19759537 21478859 IDA GO:0090263 positive regulation of canonical Wnt signaling pathway 19759537 25939383 IMP GO:0090263 positive regulation of canonical Wnt signaling pathway TAS GO:1904355 positive regulation of telomere capping 21531765 IDA GO:1904355 positive regulation of telomere capping 25939383 IMP GO:1904357 negative regulation of telomere maintenance via telomere lengthening 25939383 IMP",NAD+ ADP-ribosyltransferase activity GO:0003950 IDA 11739745 19759537 21478859 NAD+ ADP-ribosyltransferase activity GO:0003950 TAS protein binding GO:0005515 IPI 19759537 21251231 21478859 22153076 22153077 23414517 enzyme binding GO:0019899 IPI 21251231 metal ion binding GO:0046872 IEA,,chemicalprobes.org E7449,Q9H2K2,Tankyrase-2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,80351,TNKS2,"Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Signaling by Wnt R-HSA-195721 TCF dependent signaling in response to WNT R-HSA-201681 degradation of AXIN R-HSA-4641257 Signaling by WNT in cancer R-HSA-4791275 XAV939 inhibits tankyrase, stabilizing AXIN R-HSA-5545619 Diseases of signal transduction R-HSA-5663202","Golgi membrane GO:0000139 IEA pericentriolar material 11454873 GO:0000242 IDA nuclear chromosome, telomeric region 11739745 GO:0000784 IC nucleus 11739745 GO:0005634 IDA nuclear envelope 11454873 GO:0005635 IDA cytoplasm 11278563 GO:0005737 IDA cytosol GO:0005829 TAS perinuclear region of cytoplasm 11454873 GO:0048471 IDA","GO:0000209 protein polyubiquitination 19759537 21478859 IDA GO:0006471 protein ADP-ribosylation 11739745 IDA GO:0016055 Wnt signaling pathway TAS GO:0032212 positive regulation of telomere maintenance via telomerase 11739745 IC GO:0035264 multicellular organism growth IEA GO:0040014 regulation of multicellular organism growth IEA GO:0070198 protein localization to chromosome, telomeric region 11739745 IMP GO:0070213 protein auto-ADP-ribosylation 19759537 21478859 IDA GO:0090263 positive regulation of canonical Wnt signaling pathway 19759537 25939383 IMP GO:0090263 positive regulation of canonical Wnt signaling pathway TAS GO:1904355 positive regulation of telomere capping 21531765 IDA GO:1904355 positive regulation of telomere capping 25939383 IMP GO:1904357 negative regulation of telomere maintenance via telomere lengthening 25939383 IMP",NAD+ ADP-ribosyltransferase activity GO:0003950 IDA 11739745 19759537 21478859 NAD+ ADP-ribosyltransferase activity GO:0003950 TAS protein binding GO:0005515 IPI 19759537 21251231 21478859 22153076 22153077 23414517 enzyme binding GO:0019899 IPI 21251231 metal ion binding GO:0046872 IEA,,chemicalprobes.org XAV939,Q9H2K2,Tankyrase-2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,80351,TNKS2,"Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Signaling by Wnt R-HSA-195721 TCF dependent signaling in response to WNT R-HSA-201681 degradation of AXIN R-HSA-4641257 Signaling by WNT in cancer R-HSA-4791275 XAV939 inhibits tankyrase, stabilizing AXIN R-HSA-5545619 Diseases of signal transduction R-HSA-5663202","Golgi membrane GO:0000139 IEA pericentriolar material 11454873 GO:0000242 IDA nuclear chromosome, telomeric region 11739745 GO:0000784 IC nucleus 11739745 GO:0005634 IDA nuclear envelope 11454873 GO:0005635 IDA cytoplasm 11278563 GO:0005737 IDA cytosol GO:0005829 TAS perinuclear region of cytoplasm 11454873 GO:0048471 IDA","GO:0000209 protein polyubiquitination 19759537 21478859 IDA GO:0006471 protein ADP-ribosylation 11739745 IDA GO:0016055 Wnt signaling pathway TAS GO:0032212 positive regulation of telomere maintenance via telomerase 11739745 IC GO:0035264 multicellular organism growth IEA GO:0040014 regulation of multicellular organism growth IEA GO:0070198 protein localization to chromosome, telomeric region 11739745 IMP GO:0070213 protein auto-ADP-ribosylation 19759537 21478859 IDA GO:0090263 positive regulation of canonical Wnt signaling pathway 19759537 25939383 IMP GO:0090263 positive regulation of canonical Wnt signaling pathway TAS GO:1904355 positive regulation of telomere capping 21531765 IDA GO:1904355 positive regulation of telomere capping 25939383 IMP GO:1904357 negative regulation of telomere maintenance via telomere lengthening 25939383 IMP",NAD+ ADP-ribosyltransferase activity GO:0003950 IDA 11739745 19759537 21478859 NAD+ ADP-ribosyltransferase activity GO:0003950 TAS protein binding GO:0005515 IPI 19759537 21251231 21478859 22153076 22153077 23414517 enzyme binding GO:0019899 IPI 21251231 metal ion binding GO:0046872 IEA,,chemicalprobes.org GNF-5,P00519,Tyrosine-protein kinase ABL,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,25,ABL1,R-HSA-109582 Hemostasis R-HSA-1266738 Developmental Biology R-HSA-162582 Signal Transduction R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-194315 Signaling by Rho GTPases R-HSA-195258 RHO GTPase Effectors R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-375170 CDO in myogenesis R-HSA-376176 Signaling by Robo receptor R-HSA-422475 Axon guidance R-HSA-428890 Role of Abl in Robo-Slit signaling R-HSA-525793 Myogenesis R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs R-HSA-983231 Factors involved in megakaryocyte development and platelet production,17626041 17888034 GO:0005634 nucleus IDA 8242749 GO:0005634 nucleus NAS 20841568 GO:0005634 nucleus TAS GO:0005654 nucleoplasm IDA GO:0005654 nucleoplasm TAS 12944467 17626041 GO:0005730 nucleolus IDA 20841568 GO:0005737 cytoplasm TAS 24522549 GO:0005739 mitochondrion NAS 11120811 GO:0005829 cytosol IDA GO:0005829 cytosol TAS 20841568 GO:0015629 actin cytoskeleton TAS GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA GO:0031252 cell leading edge IEA GO:0031965 nuclear membrane IEA 17888034 GO:0048471 perinuclear region of cytoplasm IDA,"B-1 B cell homeostasis GO:0001922 IEA positive regulation of protein phosphorylation GO:0001934 IMP 24700464 B cell proliferation involved in immune response GO:0002322 IEA transitional one stage B cell differentiation GO:0002333 IEA mismatch repair GO:0006298 TAS 10391249 regulation of transcription, DNA-templated GO:0006355 TAS 8242749 cellular protein modification process GO:0006464 NAS 8242749 autophagy GO:0006914 IEA cellular response to DNA damage stimulus GO:0006974 IDA 15657060 DNA damage induced protein phosphorylation GO:0006975 IDA 18280240 response to oxidative stress GO:0006979 IGI 17626041 cell cycle arrest GO:0007050 TAS 24522549 mitotic nuclear division GO:0007067 TAS 24522549 epidermal growth factor receptor signaling pathway GO:0007173 IEA positive regulation of cytosolic calcium ion concentration GO:0007204 IMP 24367707 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 TAS 20841568 regulation of autophagy GO:0010506 TAS 20841568 peptidyl-tyrosine phosphorylation GO:0018108 IDA 7590236 9144171 10713049 11121037 peptidyl-tyrosine phosphorylation GO:0018108 IMP 24520051 peptidyl-tyrosine phosphorylation GO:0018108 TAS 23626584 24522549 cerebellum morphogenesis GO:0021587 IEA negative regulation of cell-cell adhesion GO:0022408 IEA microspike assembly GO:0030035 IEA actin cytoskeleton organization GO:0030036 ISS regulation of endocytosis GO:0030100 TAS 20841568 regulation of cell adhesion GO:0030155 TAS 20841568 negative regulation of BMP signaling pathway GO:0030514 IEA regulation of axon extension GO:0030516 IMP 24520051 regulation of microtubule polymerization GO:0031113 IMP 24520051 regulation of actin cytoskeleton organization GO:0032956 IMP 24520051 positive regulation of osteoblast proliferation GO:0033690 IEA substrate adhesion-dependent cell spreading GO:0034446 IEA cellular response to oxidative stress GO:0034599 TAS 24522549 platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IMP 24520051 peptidyl-tyrosine autophosphorylation GO:0038083 IDA 10518561 peptidyl-tyrosine autophosphorylation GO:0038083 IMP 24520051 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS regulation of cell proliferation GO:0042127 IBA signal transduction in response to DNA damage GO:0042770 IDA 9037071 15657060 positive regulation of apoptotic process GO:0043065 IDA 9037071 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEA negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 IEA innate immune response GO:0045087 IBA establishment of protein localization GO:0045184 IMP 24520051 negative regulation of mitotic cell cycle GO:0045930 IEA positive regulation of mitotic cell cycle GO:0045931 IEA alpha-beta T cell differentiation GO:0046632 IEA protein autophosphorylation GO:0046777 IDA 10713049 spleen development GO:0048536 IEA thymus development GO:0048538 IEA collateral sprouting GO:0048668 IEA positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA 15657060 activated T cell proliferation GO:0050798 IEA B cell receptor signaling pathway GO:0050853 IEA neuromuscular process controlling balance GO:0050885 IEA positive regulation of muscle cell differentiation GO:0051149 TAS positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IEA positive regulation of oxidoreductase activity GO:0051353 IDA 12893824 negative regulation of ubiquitin-protein transferase activity GO:0051444 IDA 20823226 negative regulation of ubiquitin-protein transferase activity GO:0051444 TAS 23626584 24522549 mitochondrial depolarization GO:0051882 TAS 24522549 Bergmann glial cell differentiation GO:0060020 IEA cellular response to hydrogen peroxide GO:0070301 IDA 10713049 negative regulation of ERK1 and ERK2 cascade GO:0070373 IEA positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA cellular response to lipopolysaccharide GO:0071222 IEA negative regulation of protein serine/threonine kinase activity GO:0071901 IDA 11121037 actin filament branching GO:0090135 IEA positive regulation of interleukin-2 secretion GO:1900042 IEA negative regulation of phospholipase C activity GO:1900275 IMP 24367707 positive regulation of neuron death GO:1901216 IEA positive regulation of interferon-gamma secretion GO:1902715 IEA regulation of extracellular matrix organization GO:1903053 IEA cellular response to dopamine GO:1903351 TAS 24522549 positive regulation of microtubule binding GO:1904528 IMP 24520051 positive regulation of actin filament binding GO:1904531 IMP 24520051 activation of protein kinase C activity GO:1990051 IDA 10713049 positive regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096 IEA regulation of cell motility GO:2000145 TAS 20841568 regulation of actin cytoskeleton reorganization GO:2000249 TAS 20841568 negative regulation of endothelial cell apoptotic process GO:2000352 IEA negative regulation of cellular senescence GO:2000773 IEA regulation of response to DNA damage stimulus GO:2001020 IDA 9461559",IDA 9144171 magnesium ion binding GO:0000287 NAS 8242749 DNA binding GO:0003677 TAS 20841568 actin monomer binding GO:0003785 TAS 20841568 nicotinate-nucleotide adenylyltransferase activity GO:0004515 IDA 11120811 protein kinase activity GO:0004672 EXP 15657136 protein tyrosine kinase activity GO:0004713 IDA 7590236 9144171 11121037 12944467 15657060 17888034 20823226 protein tyrosine kinase activity GO:0004713 IMP 24520051 protein tyrosine kinase activity GO:0004713 TAS GO:0004713 protein tyrosine kinase activity IDA 9461559 non-membrane spanning protein tyrosine kinase activity GO:0004715 IPI 10713049 protein kinase C binding GO:0005080 IBA NOT GO:0005102 receptor binding IPI 7590236 9144171 9346925 9461559 9593709 11374898 11375976 11418237 12384576 12893824 15448168 15657060 15696159 15886098 16273093 16397227 16443220 16831423 16888623 17101133 17112510 17318191 17474147 17888034 18328268 19234221 19442657 19470755 19914245 20598684 20697350 22401567 24520051 24658140 24728074 24947832 25852190 protein binding GO:0005515 IDA 9144171 ATP binding GO:0005524 IPI 11971963 protein C-terminus binding GO:0008022 IPI 7590236 SH3 domain binding GO:0017124 IPI 23006999 syntaxin binding GO:0019905 IDA 9144171 manganese ion binding GO:0030145 IEA GO:0051015 actin filament binding IPI 11121037 mitogen-activated protein kinase binding GO:0051019 IDA 15657060 proline-rich region binding GO:0070064 IPI 7590236 proline-rich region binding GO:0070064,ErbB signaling pathway - Homo sapiens (human) hsa04012 Ras signaling pathway - Homo sapiens (human) hsa04014 Cell cycle - Homo sapiens (human) hsa04110 Axon guidance - Homo sapiens (human) hsa04360 Neurotrophin signaling pathway - Homo sapiens (human) hsa04722 Pathogenic Escherichia coli infection - Homo sapiens (human) hsa05130 Shigellosis - Homo sapiens (human) hsa05131 Pathways in cancer - Homo sapiens (human) hsa05200 MicroRNAs in cancer - Homo sapiens (human) hsa05206 Chronic myeloid leukemia - Homo sapiens (human) hsa05220 Viral myocarditis - Homo sapiens (human) hsa05416,chemicalprobes.org Bafetinib,P00519,Tyrosine-protein kinase ABL,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,25,ABL1,R-HSA-109582 Hemostasis R-HSA-1266738 Developmental Biology R-HSA-162582 Signal Transduction R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-194315 Signaling by Rho GTPases R-HSA-195258 RHO GTPase Effectors R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-375170 CDO in myogenesis R-HSA-376176 Signaling by Robo receptor R-HSA-422475 Axon guidance R-HSA-428890 Role of Abl in Robo-Slit signaling R-HSA-525793 Myogenesis R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs R-HSA-983231 Factors involved in megakaryocyte development and platelet production,17626041 17888034 GO:0005634 nucleus IDA 8242749 GO:0005634 nucleus NAS 20841568 GO:0005634 nucleus TAS GO:0005654 nucleoplasm IDA GO:0005654 nucleoplasm TAS 12944467 17626041 GO:0005730 nucleolus IDA 20841568 GO:0005737 cytoplasm TAS 24522549 GO:0005739 mitochondrion NAS 11120811 GO:0005829 cytosol IDA GO:0005829 cytosol TAS 20841568 GO:0015629 actin cytoskeleton TAS GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA GO:0031252 cell leading edge IEA GO:0031965 nuclear membrane IEA 17888034 GO:0048471 perinuclear region of cytoplasm IDA,"B-1 B cell homeostasis GO:0001922 IEA positive regulation of protein phosphorylation GO:0001934 IMP 24700464 B cell proliferation involved in immune response GO:0002322 IEA transitional one stage B cell differentiation GO:0002333 IEA mismatch repair GO:0006298 TAS 10391249 regulation of transcription, DNA-templated GO:0006355 TAS 8242749 cellular protein modification process GO:0006464 NAS 8242749 autophagy GO:0006914 IEA cellular response to DNA damage stimulus GO:0006974 IDA 15657060 DNA damage induced protein phosphorylation GO:0006975 IDA 18280240 response to oxidative stress GO:0006979 IGI 17626041 cell cycle arrest GO:0007050 TAS 24522549 mitotic nuclear division GO:0007067 TAS 24522549 epidermal growth factor receptor signaling pathway GO:0007173 IEA positive regulation of cytosolic calcium ion concentration GO:0007204 IMP 24367707 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 TAS 20841568 regulation of autophagy GO:0010506 TAS 20841568 peptidyl-tyrosine phosphorylation GO:0018108 IDA 7590236 9144171 10713049 11121037 peptidyl-tyrosine phosphorylation GO:0018108 IMP 24520051 peptidyl-tyrosine phosphorylation GO:0018108 TAS 23626584 24522549 cerebellum morphogenesis GO:0021587 IEA negative regulation of cell-cell adhesion GO:0022408 IEA microspike assembly GO:0030035 IEA actin cytoskeleton organization GO:0030036 ISS regulation of endocytosis GO:0030100 TAS 20841568 regulation of cell adhesion GO:0030155 TAS 20841568 negative regulation of BMP signaling pathway GO:0030514 IEA regulation of axon extension GO:0030516 IMP 24520051 regulation of microtubule polymerization GO:0031113 IMP 24520051 regulation of actin cytoskeleton organization GO:0032956 IMP 24520051 positive regulation of osteoblast proliferation GO:0033690 IEA substrate adhesion-dependent cell spreading GO:0034446 IEA cellular response to oxidative stress GO:0034599 TAS 24522549 platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IMP 24520051 peptidyl-tyrosine autophosphorylation GO:0038083 IDA 10518561 peptidyl-tyrosine autophosphorylation GO:0038083 IMP 24520051 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS regulation of cell proliferation GO:0042127 IBA signal transduction in response to DNA damage GO:0042770 IDA 9037071 15657060 positive regulation of apoptotic process GO:0043065 IDA 9037071 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEA negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 IEA innate immune response GO:0045087 IBA establishment of protein localization GO:0045184 IMP 24520051 negative regulation of mitotic cell cycle GO:0045930 IEA positive regulation of mitotic cell cycle GO:0045931 IEA alpha-beta T cell differentiation GO:0046632 IEA protein autophosphorylation GO:0046777 IDA 10713049 spleen development GO:0048536 IEA thymus development GO:0048538 IEA collateral sprouting GO:0048668 IEA positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA 15657060 activated T cell proliferation GO:0050798 IEA B cell receptor signaling pathway GO:0050853 IEA neuromuscular process controlling balance GO:0050885 IEA positive regulation of muscle cell differentiation GO:0051149 TAS positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IEA positive regulation of oxidoreductase activity GO:0051353 IDA 12893824 negative regulation of ubiquitin-protein transferase activity GO:0051444 IDA 20823226 negative regulation of ubiquitin-protein transferase activity GO:0051444 TAS 23626584 24522549 mitochondrial depolarization GO:0051882 TAS 24522549 Bergmann glial cell differentiation GO:0060020 IEA cellular response to hydrogen peroxide GO:0070301 IDA 10713049 negative regulation of ERK1 and ERK2 cascade GO:0070373 IEA positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA cellular response to lipopolysaccharide GO:0071222 IEA negative regulation of protein serine/threonine kinase activity GO:0071901 IDA 11121037 actin filament branching GO:0090135 IEA positive regulation of interleukin-2 secretion GO:1900042 IEA negative regulation of phospholipase C activity GO:1900275 IMP 24367707 positive regulation of neuron death GO:1901216 IEA positive regulation of interferon-gamma secretion GO:1902715 IEA regulation of extracellular matrix organization GO:1903053 IEA cellular response to dopamine GO:1903351 TAS 24522549 positive regulation of microtubule binding GO:1904528 IMP 24520051 positive regulation of actin filament binding GO:1904531 IMP 24520051 activation of protein kinase C activity GO:1990051 IDA 10713049 positive regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096 IEA regulation of cell motility GO:2000145 TAS 20841568 regulation of actin cytoskeleton reorganization GO:2000249 TAS 20841568 negative regulation of endothelial cell apoptotic process GO:2000352 IEA negative regulation of cellular senescence GO:2000773 IEA regulation of response to DNA damage stimulus GO:2001020 IDA 9461559",IDA 9144171 magnesium ion binding GO:0000287 NAS 8242749 DNA binding GO:0003677 TAS 20841568 actin monomer binding GO:0003785 TAS 20841568 nicotinate-nucleotide adenylyltransferase activity GO:0004515 IDA 11120811 protein kinase activity GO:0004672 EXP 15657136 protein tyrosine kinase activity GO:0004713 IDA 7590236 9144171 11121037 12944467 15657060 17888034 20823226 protein tyrosine kinase activity GO:0004713 IMP 24520051 protein tyrosine kinase activity GO:0004713 TAS GO:0004713 protein tyrosine kinase activity IDA 9461559 non-membrane spanning protein tyrosine kinase activity GO:0004715 IPI 10713049 protein kinase C binding GO:0005080 IBA NOT GO:0005102 receptor binding IPI 7590236 9144171 9346925 9461559 9593709 11374898 11375976 11418237 12384576 12893824 15448168 15657060 15696159 15886098 16273093 16397227 16443220 16831423 16888623 17101133 17112510 17318191 17474147 17888034 18328268 19234221 19442657 19470755 19914245 20598684 20697350 22401567 24520051 24658140 24728074 24947832 25852190 protein binding GO:0005515 IDA 9144171 ATP binding GO:0005524 IPI 11971963 protein C-terminus binding GO:0008022 IPI 7590236 SH3 domain binding GO:0017124 IPI 23006999 syntaxin binding GO:0019905 IDA 9144171 manganese ion binding GO:0030145 IEA GO:0051015 actin filament binding IPI 11121037 mitogen-activated protein kinase binding GO:0051019 IDA 15657060 proline-rich region binding GO:0070064 IPI 7590236 proline-rich region binding GO:0070064,ErbB signaling pathway - Homo sapiens (human) hsa04012 Ras signaling pathway - Homo sapiens (human) hsa04014 Cell cycle - Homo sapiens (human) hsa04110 Axon guidance - Homo sapiens (human) hsa04360 Neurotrophin signaling pathway - Homo sapiens (human) hsa04722 Pathogenic Escherichia coli infection - Homo sapiens (human) hsa05130 Shigellosis - Homo sapiens (human) hsa05131 Pathways in cancer - Homo sapiens (human) hsa05200 MicroRNAs in cancer - Homo sapiens (human) hsa05206 Chronic myeloid leukemia - Homo sapiens (human) hsa05220 Viral myocarditis - Homo sapiens (human) hsa05416,chemicalprobes.org Imatinib,P00519,Tyrosine-protein kinase ABL,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,25,ABL1,R-HSA-109582 Hemostasis R-HSA-1266738 Developmental Biology R-HSA-162582 Signal Transduction R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-194315 Signaling by Rho GTPases R-HSA-195258 RHO GTPase Effectors R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-375170 CDO in myogenesis R-HSA-376176 Signaling by Robo receptor R-HSA-422475 Axon guidance R-HSA-428890 Role of Abl in Robo-Slit signaling R-HSA-525793 Myogenesis R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs R-HSA-983231 Factors involved in megakaryocyte development and platelet production,17626041 17888034 GO:0005634 nucleus IDA 8242749 GO:0005634 nucleus NAS 20841568 GO:0005634 nucleus TAS GO:0005654 nucleoplasm IDA GO:0005654 nucleoplasm TAS 12944467 17626041 GO:0005730 nucleolus IDA 20841568 GO:0005737 cytoplasm TAS 24522549 GO:0005739 mitochondrion NAS 11120811 GO:0005829 cytosol IDA GO:0005829 cytosol TAS 20841568 GO:0015629 actin cytoskeleton TAS GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA GO:0031252 cell leading edge IEA GO:0031965 nuclear membrane IEA 17888034 GO:0048471 perinuclear region of cytoplasm IDA,"B-1 B cell homeostasis GO:0001922 IEA positive regulation of protein phosphorylation GO:0001934 IMP 24700464 B cell proliferation involved in immune response GO:0002322 IEA transitional one stage B cell differentiation GO:0002333 IEA mismatch repair GO:0006298 TAS 10391249 regulation of transcription, DNA-templated GO:0006355 TAS 8242749 cellular protein modification process GO:0006464 NAS 8242749 autophagy GO:0006914 IEA cellular response to DNA damage stimulus GO:0006974 IDA 15657060 DNA damage induced protein phosphorylation GO:0006975 IDA 18280240 response to oxidative stress GO:0006979 IGI 17626041 cell cycle arrest GO:0007050 TAS 24522549 mitotic nuclear division GO:0007067 TAS 24522549 epidermal growth factor receptor signaling pathway GO:0007173 IEA positive regulation of cytosolic calcium ion concentration GO:0007204 IMP 24367707 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 TAS 20841568 regulation of autophagy GO:0010506 TAS 20841568 peptidyl-tyrosine phosphorylation GO:0018108 IDA 7590236 9144171 10713049 11121037 peptidyl-tyrosine phosphorylation GO:0018108 IMP 24520051 peptidyl-tyrosine phosphorylation GO:0018108 TAS 23626584 24522549 cerebellum morphogenesis GO:0021587 IEA negative regulation of cell-cell adhesion GO:0022408 IEA microspike assembly GO:0030035 IEA actin cytoskeleton organization GO:0030036 ISS regulation of endocytosis GO:0030100 TAS 20841568 regulation of cell adhesion GO:0030155 TAS 20841568 negative regulation of BMP signaling pathway GO:0030514 IEA regulation of axon extension GO:0030516 IMP 24520051 regulation of microtubule polymerization GO:0031113 IMP 24520051 regulation of actin cytoskeleton organization GO:0032956 IMP 24520051 positive regulation of osteoblast proliferation GO:0033690 IEA substrate adhesion-dependent cell spreading GO:0034446 IEA cellular response to oxidative stress GO:0034599 TAS 24522549 platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IMP 24520051 peptidyl-tyrosine autophosphorylation GO:0038083 IDA 10518561 peptidyl-tyrosine autophosphorylation GO:0038083 IMP 24520051 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS regulation of cell proliferation GO:0042127 IBA signal transduction in response to DNA damage GO:0042770 IDA 9037071 15657060 positive regulation of apoptotic process GO:0043065 IDA 9037071 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEA negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 IEA innate immune response GO:0045087 IBA establishment of protein localization GO:0045184 IMP 24520051 negative regulation of mitotic cell cycle GO:0045930 IEA positive regulation of mitotic cell cycle GO:0045931 IEA alpha-beta T cell differentiation GO:0046632 IEA protein autophosphorylation GO:0046777 IDA 10713049 spleen development GO:0048536 IEA thymus development GO:0048538 IEA collateral sprouting GO:0048668 IEA positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IDA 15657060 activated T cell proliferation GO:0050798 IEA B cell receptor signaling pathway GO:0050853 IEA neuromuscular process controlling balance GO:0050885 IEA positive regulation of muscle cell differentiation GO:0051149 TAS positive regulation of release of sequestered calcium ion into cytosol GO:0051281 IEA positive regulation of oxidoreductase activity GO:0051353 IDA 12893824 negative regulation of ubiquitin-protein transferase activity GO:0051444 IDA 20823226 negative regulation of ubiquitin-protein transferase activity GO:0051444 TAS 23626584 24522549 mitochondrial depolarization GO:0051882 TAS 24522549 Bergmann glial cell differentiation GO:0060020 IEA cellular response to hydrogen peroxide GO:0070301 IDA 10713049 negative regulation of ERK1 and ERK2 cascade GO:0070373 IEA positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA cellular response to lipopolysaccharide GO:0071222 IEA negative regulation of protein serine/threonine kinase activity GO:0071901 IDA 11121037 actin filament branching GO:0090135 IEA positive regulation of interleukin-2 secretion GO:1900042 IEA negative regulation of phospholipase C activity GO:1900275 IMP 24367707 positive regulation of neuron death GO:1901216 IEA positive regulation of interferon-gamma secretion GO:1902715 IEA regulation of extracellular matrix organization GO:1903053 IEA cellular response to dopamine GO:1903351 TAS 24522549 positive regulation of microtubule binding GO:1904528 IMP 24520051 positive regulation of actin filament binding GO:1904531 IMP 24520051 activation of protein kinase C activity GO:1990051 IDA 10713049 positive regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096 IEA regulation of cell motility GO:2000145 TAS 20841568 regulation of actin cytoskeleton reorganization GO:2000249 TAS 20841568 negative regulation of endothelial cell apoptotic process GO:2000352 IEA negative regulation of cellular senescence GO:2000773 IEA regulation of response to DNA damage stimulus GO:2001020 IDA 9461559",IDA 9144171 magnesium ion binding GO:0000287 NAS 8242749 DNA binding GO:0003677 TAS 20841568 actin monomer binding GO:0003785 TAS 20841568 nicotinate-nucleotide adenylyltransferase activity GO:0004515 IDA 11120811 protein kinase activity GO:0004672 EXP 15657136 protein tyrosine kinase activity GO:0004713 IDA 7590236 9144171 11121037 12944467 15657060 17888034 20823226 protein tyrosine kinase activity GO:0004713 IMP 24520051 protein tyrosine kinase activity GO:0004713 TAS GO:0004713 protein tyrosine kinase activity IDA 9461559 non-membrane spanning protein tyrosine kinase activity GO:0004715 IPI 10713049 protein kinase C binding GO:0005080 IBA NOT GO:0005102 receptor binding IPI 7590236 9144171 9346925 9461559 9593709 11374898 11375976 11418237 12384576 12893824 15448168 15657060 15696159 15886098 16273093 16397227 16443220 16831423 16888623 17101133 17112510 17318191 17474147 17888034 18328268 19234221 19442657 19470755 19914245 20598684 20697350 22401567 24520051 24658140 24728074 24947832 25852190 protein binding GO:0005515 IDA 9144171 ATP binding GO:0005524 IPI 11971963 protein C-terminus binding GO:0008022 IPI 7590236 SH3 domain binding GO:0017124 IPI 23006999 syntaxin binding GO:0019905 IDA 9144171 manganese ion binding GO:0030145 IEA GO:0051015 actin filament binding IPI 11121037 mitogen-activated protein kinase binding GO:0051019 IDA 15657060 proline-rich region binding GO:0070064 IPI 7590236 proline-rich region binding GO:0070064,ErbB signaling pathway - Homo sapiens (human) hsa04012 Ras signaling pathway - Homo sapiens (human) hsa04014 Cell cycle - Homo sapiens (human) hsa04110 Axon guidance - Homo sapiens (human) hsa04360 Neurotrophin signaling pathway - Homo sapiens (human) hsa04722 Pathogenic Escherichia coli infection - Homo sapiens (human) hsa05130 Shigellosis - Homo sapiens (human) hsa05131 Pathways in cancer - Homo sapiens (human) hsa05200 MicroRNAs in cancer - Homo sapiens (human) hsa05206 Chronic myeloid leukemia - Homo sapiens (human) hsa05220 Viral myocarditis - Homo sapiens (human) hsa05416,chemicalprobes.org BMX-IN-1,P51813,Tyrosine-protein kinase BMX,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,660,BMX,Apoptosis R-HSA-109581 Apoptotic cleavage of cellular proteins R-HSA-111465 Programmed Cell Death R-HSA-5357801 Apoptotic execution phase R-HSA-75153,TAS GO:0005829 cytosol IBA GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA 11331870 ruffle membrane GO:0032587,NK T cell differentiation GO:0001865 IBA protein phosphorylation 7970727 GO:0006468 TAS cellular component disassembly involved in execution phase of apoptosis GO:0006921 TAS signal transduction 10688651 11331870 GO:0007165 IDA transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA mesoderm development 9520419 GO:0007498 TAS intracellular signal transduction GO:0035556 IEA peptidyl-tyrosine autophosphorylation GO:0038083 IBA regulation of cell proliferation GO:0042127 IBA innate immune response GO:0045087 IBA protein autophosphorylation 11331870 GO:0046777 IDA,protein tyrosine kinase activity 7970727 GO:0004713 TAS non-membrane spanning protein tyrosine kinase activity 10688651 11331870 GO:0004715 IDA signal transducer activity 9520419 GO:0004871 TAS receptor binding NOT GO:0005102 IBA protein binding 10688651 11331870 16186805 25416956 25814554 GO:0005515 IPI ATP binding GO:0005524 IEA metal ion binding GO:0046872 IEA,,chemicalprobes.org CGI1746,Q06187,Tyrosine-protein kinase BTK,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,695,BTK,R-HSA-1280218 Adaptive Immune System R-HSA-162582 Signal Transduction R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166054 Activated TLR4 signalling R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-168898 Toll-Like Receptors Cascades R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-194315 Signaling by Rho GTPases R-HSA-195258 RHO GTPase Effectors R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-2172127 DAP12 interactions R-HSA-2424491 DAP12 signaling R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983705 Signaling by the B Cell Receptor (BCR),GO:0005634 nucleus 19290921 TAS GO:0005737 cytoplasm 15046600 TAS GO:0005829 cytosol 17823121 IDA GO:0005829 cytosol 19290921 TAS GO:0005886 plasma membrane 17823121 IDA GO:0005886 plasma membrane 19290921 TAS GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA GO:0031410 cytoplasmic vesicle IEA GO:0043231 intracellular membrane-bounded organelle IDA GO:0045121 membrane raft 15046600 IDA,"IEA GO:0001818 negative regulation of cytokine production TAS 19290921 adaptive immune response GO:0002250 TAS 19290921 regulation of B cell cytokine production GO:0002721 TAS GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS 19290921 regulation of B cell apoptotic process GO:0002902 IEA GO:0006351 transcription, DNA-templated TAS 11913944 protein phosphorylation GO:0006468 IBA GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA GO:0007249 I-kappaB kinase/NF-kappaB signaling TAS 8013627 mesoderm development GO:0007498 IDA 11606584 peptidyl-tyrosine phosphorylation GO:0018108 TAS 15046600 calcium-mediated signaling GO:0019722 TAS 11913944 intracellular signal transduction GO:0035556 IBA GO:0038083 peptidyl-tyrosine autophosphorylation TAS GO:0038095 Fc-epsilon receptor signaling pathway TAS 19290921 B cell activation GO:0042113 IBA GO:0042127 regulation of cell proliferation TAS 19290921 innate immune response GO:0045087 TAS 19290921 positive regulation of B cell differentiation GO:0045579 IEA GO:0048469 cell maturation TAS 19290921 B cell receptor signaling pathway GO:0050853 TAS 19290921 positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS 8688094 apoptotic signaling pathway GO:0097190","protein tyrosine kinase activity GO:0004713 7518558 EXP protein tyrosine kinase activity GO:0004713 11913944 TAS non-membrane spanning protein tyrosine kinase activity GO:0004715 19290921 TAS receptor binding GO:0005102 IBA NOT protein binding GO:0005515 8892607 9012831 9571151 11788586 15046600 15539407 16969585 19214191 22366891 22939624 IPI ATP binding GO:0005524 11913944 TAS phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 17823121 IDA identical protein binding GO:0042802 11577348 IPI metal ion binding GO:0046872 IEA",NF-kappa B signaling pathway - Homo sapiens (human) hsa04064 Osteoclast differentiation - Homo sapiens (human) hsa04380 Platelet activation - Homo sapiens (human) hsa04611 B cell receptor signaling pathway - Homo sapiens (human) hsa04662 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04664 Primary immunodeficiency - Homo sapiens (human) hsa05340,chemicalprobes.org AVL-292,Q06187,Tyrosine-protein kinase BTK,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,695,BTK,R-HSA-1280218 Adaptive Immune System R-HSA-162582 Signal Transduction R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166054 Activated TLR4 signalling R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-168898 Toll-Like Receptors Cascades R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-194315 Signaling by Rho GTPases R-HSA-195258 RHO GTPase Effectors R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-2172127 DAP12 interactions R-HSA-2424491 DAP12 signaling R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983705 Signaling by the B Cell Receptor (BCR),GO:0005634 nucleus 19290921 TAS GO:0005737 cytoplasm 15046600 TAS GO:0005829 cytosol 17823121 IDA GO:0005829 cytosol 19290921 TAS GO:0005886 plasma membrane 17823121 IDA GO:0005886 plasma membrane 19290921 TAS GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA GO:0031410 cytoplasmic vesicle IEA GO:0043231 intracellular membrane-bounded organelle IDA GO:0045121 membrane raft 15046600 IDA,"IEA GO:0001818 negative regulation of cytokine production TAS 19290921 adaptive immune response GO:0002250 TAS 19290921 regulation of B cell cytokine production GO:0002721 TAS GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS 19290921 regulation of B cell apoptotic process GO:0002902 IEA GO:0006351 transcription, DNA-templated TAS 11913944 protein phosphorylation GO:0006468 IBA GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA GO:0007249 I-kappaB kinase/NF-kappaB signaling TAS 8013627 mesoderm development GO:0007498 IDA 11606584 peptidyl-tyrosine phosphorylation GO:0018108 TAS 15046600 calcium-mediated signaling GO:0019722 TAS 11913944 intracellular signal transduction GO:0035556 IBA GO:0038083 peptidyl-tyrosine autophosphorylation TAS GO:0038095 Fc-epsilon receptor signaling pathway TAS 19290921 B cell activation GO:0042113 IBA GO:0042127 regulation of cell proliferation TAS 19290921 innate immune response GO:0045087 TAS 19290921 positive regulation of B cell differentiation GO:0045579 IEA GO:0048469 cell maturation TAS 19290921 B cell receptor signaling pathway GO:0050853 TAS 19290921 positive regulation of NF-kappaB transcription factor activity GO:0051092 TAS 8688094 apoptotic signaling pathway GO:0097190","protein tyrosine kinase activity GO:0004713 7518558 EXP protein tyrosine kinase activity GO:0004713 11913944 TAS non-membrane spanning protein tyrosine kinase activity GO:0004715 19290921 TAS receptor binding GO:0005102 IBA NOT protein binding GO:0005515 8892607 9012831 9571151 11788586 15046600 15539407 16969585 19214191 22366891 22939624 IPI ATP binding GO:0005524 11913944 TAS phosphatidylinositol-3,4,5-trisphosphate binding GO:0005547 17823121 IDA identical protein binding GO:0042802 11577348 IPI metal ion binding GO:0046872 IEA",NF-kappa B signaling pathway - Homo sapiens (human) hsa04064 Osteoclast differentiation - Homo sapiens (human) hsa04380 Platelet activation - Homo sapiens (human) hsa04611 B cell receptor signaling pathway - Homo sapiens (human) hsa04662 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04664 Primary immunodeficiency - Homo sapiens (human) hsa05340,chemicalprobes.org Ruxolitinib,P23458,Tyrosine-protein kinase JAK1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,3716,JAK1,"Interleukin-6 signaling R-HSA-1059683 Hemostasis R-HSA-109582 MAPK3 (ERK1) activation R-HSA-110056 IRS-mediated signalling R-HSA-112399 RAF-independent MAPK1/3 activation R-HSA-112409 MAPK1 (ERK2) activation R-HSA-112411 SOS-mediated signalling R-HSA-112412 GPVI-mediated activation cascade R-HSA-114604 ISG15 antiviral mechanism R-HSA-1169408 Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 SHC1 events in ERBB2 signaling R-HSA-1250196 SHC1 events in ERBB4 signaling R-HSA-1250347 Interleukin-7 signaling R-HSA-1266695 Developmental Biology R-HSA-1266738 Cytokine Signaling in Immune system R-HSA-1280215 Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Prolonged ERK activation events R-HSA-169893 Frs2-mediated activation R-HSA-170968 ARMS-mediated activation R-HSA-170984 Signaling by EGFR R-HSA-177929 GRB2 events in EGFR signaling R-HSA-179812 SHC1 events in EGFR signaling R-HSA-180336 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signalling to p38 via RIT and RIN R-HSA-187706 Signaling by FGFR R-HSA-190236 Signaling by VEGF R-HSA-194138 GRB2 events in ERBB2 signaling R-HSA-1963640 DAP12 interactions R-HSA-2172127 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Signaling by Leptin R-HSA-2586552 FCERI mediated MAPK activation R-HSA-2871796 Signaling by GPCR R-HSA-372790 NCAM signaling for neurite out-growth R-HSA-375165 GPCR downstream signaling R-HSA-388396 G beta:gamma signalling through PI3Kgamma R-HSA-392451 G-protein beta:gamma signalling R-HSA-397795 Axon guidance R-HSA-422475 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signaling by Interleukins R-HSA-449147 Interleukin-2 signaling R-HSA-451927 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 VEGFR2 mediated cell proliferation R-HSA-5218921 Downstream signaling of activated FGFR1 R-HSA-5654687 FRS-mediated FGFR1 signaling R-HSA-5654693 Downstream signaling of activated FGFR2 R-HSA-5654696 FRS-mediated FGFR2 signaling R-HSA-5654700 FRS-mediated FGFR3 signaling R-HSA-5654706 Downstream signaling of activated FGFR3 R-HSA-5654708 FRS-mediated FGFR4 signaling R-HSA-5654712 Downstream signaling of activated FGFR4 R-HSA-5654716 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 RAF/MAP kinase cascade R-HSA-5673001 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Platelet activation, signaling and aggregation R-HSA-76002 Interferon gamma signaling R-HSA-877300 Regulation of IFNG signaling R-HSA-877312 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 Interferon alpha/beta signaling R-HSA-909733 Interleukin receptor SHC signaling R-HSA-912526 Regulation of IFNA signaling R-HSA-912694 Interferon Signaling R-HSA-913531",10502458 IDA GO:0005634 nucleus 10502458 IDA GO:0005737 cytoplasm TAS GO:0005829 cytosol IEA GO:0005856 cytoskeleton 21423176 IDA GO:0005925 focal adhesion IEA GO:0012505 endomembrane system IBA GO:0031234 extrinsic component of cytoplasmic side of plasma membrane,MAPK cascade GO:0000165 TAS protein phosphorylation 1848670 GO:0006468 TAS transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA cell migration GO:0016477 IBA cell differentiation GO:0030154 IBA intracellular signal transduction 8232552 GO:0035556 TAS peptidyl-tyrosine autophosphorylation GO:0038083 IBA interleukin-2-mediated signaling pathway 11909529 GO:0038110 IDA regulation of cell proliferation GO:0042127 IBA positive regulation of GTPase activity GO:0043547 IEA innate immune response GO:0045087 IBA response to antibiotic 16280321 GO:0046677 IDA interferon-gamma-mediated signaling pathway GO:0060333 TAS regulation of interferon-gamma-mediated signaling pathway GO:0060334 TAS type I interferon signaling pathway GO:0060337 TAS regulation of type I interferon-mediated signaling pathway GO:0060338 TAS positive regulation of sprouting angiogenesis 20299512 GO:1903672 IGI,protein tyrosine kinase activity EXP 1386289 8232552 10825200 GO:0004713 protein tyrosine kinase activity TAS GO:0004713 non-membrane spanning protein tyrosine kinase activity IBA GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS GO:0004715 Ras guanyl-nucleotide exchange factor activity TAS GO:0005088 receptor binding IBA GO:0005102 growth hormone receptor binding ISS 10502458 GO:0005131 protein binding IPI 7759950 16273093 16710296 GO:0005515 ATP binding IEA GO:0005524 protein phosphatase binding IPI 11909529 GO:0019903 ubiquitin protein ligase binding IPI 24882218 GO:0031625 CCR5 chemokine receptor binding IEA GO:0031730 metal ion binding IEA GO:0046872,PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Osteoclast differentiation - Homo sapiens (human) hsa04380 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04550 Jak-STAT signaling pathway - Homo sapiens (human) hsa04630 Leishmaniasis - Homo sapiens (human) hsa05140 Toxoplasmosis - Homo sapiens (human) hsa05145 Tuberculosis - Homo sapiens (human) hsa05152 Hepatitis C - Homo sapiens (human) hsa05160 Hepatitis B - Homo sapiens (human) hsa05161 Measles - Homo sapiens (human) hsa05162 Influenza A - Homo sapiens (human) hsa05164 HTLV-I infection - Homo sapiens (human) hsa05166 Herpes simplex infection - Homo sapiens (human) hsa05168 Epstein-Barr virus infection - Homo sapiens (human) hsa05169 Pathways in cancer - Homo sapiens (human) hsa05200 Viral carcinogenesis - Homo sapiens (human) hsa05203 Pancreatic cancer - Homo sapiens (human) hsa05212,chemicalprobes.org Tofacitinib,P23458,Tyrosine-protein kinase JAK1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,3716,JAK1,"Interleukin-6 signaling R-HSA-1059683 Hemostasis R-HSA-109582 MAPK3 (ERK1) activation R-HSA-110056 IRS-mediated signalling R-HSA-112399 RAF-independent MAPK1/3 activation R-HSA-112409 MAPK1 (ERK2) activation R-HSA-112411 SOS-mediated signalling R-HSA-112412 GPVI-mediated activation cascade R-HSA-114604 ISG15 antiviral mechanism R-HSA-1169408 Antiviral mechanism by IFN-stimulated genes R-HSA-1169410 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 SHC1 events in ERBB2 signaling R-HSA-1250196 SHC1 events in ERBB4 signaling R-HSA-1250347 Interleukin-7 signaling R-HSA-1266695 Developmental Biology R-HSA-1266738 Cytokine Signaling in Immune system R-HSA-1280215 Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Prolonged ERK activation events R-HSA-169893 Frs2-mediated activation R-HSA-170968 ARMS-mediated activation R-HSA-170984 Signaling by EGFR R-HSA-177929 GRB2 events in EGFR signaling R-HSA-179812 SHC1 events in EGFR signaling R-HSA-180336 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signalling to p38 via RIT and RIN R-HSA-187706 Signaling by FGFR R-HSA-190236 Signaling by VEGF R-HSA-194138 GRB2 events in ERBB2 signaling R-HSA-1963640 DAP12 interactions R-HSA-2172127 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Signaling by Leptin R-HSA-2586552 FCERI mediated MAPK activation R-HSA-2871796 Signaling by GPCR R-HSA-372790 NCAM signaling for neurite out-growth R-HSA-375165 GPCR downstream signaling R-HSA-388396 G beta:gamma signalling through PI3Kgamma R-HSA-392451 G-protein beta:gamma signalling R-HSA-397795 Axon guidance R-HSA-422475 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signaling by Interleukins R-HSA-449147 Interleukin-2 signaling R-HSA-451927 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 VEGFR2 mediated cell proliferation R-HSA-5218921 Downstream signaling of activated FGFR1 R-HSA-5654687 FRS-mediated FGFR1 signaling R-HSA-5654693 Downstream signaling of activated FGFR2 R-HSA-5654696 FRS-mediated FGFR2 signaling R-HSA-5654700 FRS-mediated FGFR3 signaling R-HSA-5654706 Downstream signaling of activated FGFR3 R-HSA-5654708 FRS-mediated FGFR4 signaling R-HSA-5654712 Downstream signaling of activated FGFR4 R-HSA-5654716 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 RAF/MAP kinase cascade R-HSA-5673001 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Platelet activation, signaling and aggregation R-HSA-76002 Interferon gamma signaling R-HSA-877300 Regulation of IFNG signaling R-HSA-877312 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 Interferon alpha/beta signaling R-HSA-909733 Interleukin receptor SHC signaling R-HSA-912526 Regulation of IFNA signaling R-HSA-912694 Interferon Signaling R-HSA-913531",10502458 IDA GO:0005634 nucleus 10502458 IDA GO:0005737 cytoplasm TAS GO:0005829 cytosol IEA GO:0005856 cytoskeleton 21423176 IDA GO:0005925 focal adhesion IEA GO:0012505 endomembrane system IBA GO:0031234 extrinsic component of cytoplasmic side of plasma membrane,MAPK cascade GO:0000165 TAS protein phosphorylation 1848670 GO:0006468 TAS transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA cell migration GO:0016477 IBA cell differentiation GO:0030154 IBA intracellular signal transduction 8232552 GO:0035556 TAS peptidyl-tyrosine autophosphorylation GO:0038083 IBA interleukin-2-mediated signaling pathway 11909529 GO:0038110 IDA regulation of cell proliferation GO:0042127 IBA positive regulation of GTPase activity GO:0043547 IEA innate immune response GO:0045087 IBA response to antibiotic 16280321 GO:0046677 IDA interferon-gamma-mediated signaling pathway GO:0060333 TAS regulation of interferon-gamma-mediated signaling pathway GO:0060334 TAS type I interferon signaling pathway GO:0060337 TAS regulation of type I interferon-mediated signaling pathway GO:0060338 TAS positive regulation of sprouting angiogenesis 20299512 GO:1903672 IGI,protein tyrosine kinase activity EXP 1386289 8232552 10825200 GO:0004713 protein tyrosine kinase activity TAS GO:0004713 non-membrane spanning protein tyrosine kinase activity IBA GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS GO:0004715 Ras guanyl-nucleotide exchange factor activity TAS GO:0005088 receptor binding IBA GO:0005102 growth hormone receptor binding ISS 10502458 GO:0005131 protein binding IPI 7759950 16273093 16710296 GO:0005515 ATP binding IEA GO:0005524 protein phosphatase binding IPI 11909529 GO:0019903 ubiquitin protein ligase binding IPI 24882218 GO:0031625 CCR5 chemokine receptor binding IEA GO:0031730 metal ion binding IEA GO:0046872,PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Osteoclast differentiation - Homo sapiens (human) hsa04380 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04550 Jak-STAT signaling pathway - Homo sapiens (human) hsa04630 Leishmaniasis - Homo sapiens (human) hsa05140 Toxoplasmosis - Homo sapiens (human) hsa05145 Tuberculosis - Homo sapiens (human) hsa05152 Hepatitis C - Homo sapiens (human) hsa05160 Hepatitis B - Homo sapiens (human) hsa05161 Measles - Homo sapiens (human) hsa05162 Influenza A - Homo sapiens (human) hsa05164 HTLV-I infection - Homo sapiens (human) hsa05166 Herpes simplex infection - Homo sapiens (human) hsa05168 Epstein-Barr virus infection - Homo sapiens (human) hsa05169 Pathways in cancer - Homo sapiens (human) hsa05200 Viral carcinogenesis - Homo sapiens (human) hsa05203 Pancreatic cancer - Homo sapiens (human) hsa05212,chemicalprobes.org Ruxolitinib,O60674,Tyrosine-protein kinase JAK2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,3717,JAK2,"Interleukin-6 signaling R-HSA-1059683 Hemostasis R-HSA-109582 MAPK3 (ERK1) activation R-HSA-110056 IRS-mediated signalling R-HSA-112399 RAF-independent MAPK1/3 activation R-HSA-112409 MAPK1 (ERK2) activation R-HSA-112411 SOS-mediated signalling R-HSA-112412 GPVI-mediated activation cascade R-HSA-114604 Prolactin receptor signaling R-HSA-1170546 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 SHC1 events in ERBB2 signaling R-HSA-1250196 SHC1 events in ERBB4 signaling R-HSA-1250347 Nuclear signaling by ERBB4 R-HSA-1251985 Developmental Biology R-HSA-1266738 Cytokine Signaling in Immune system R-HSA-1280215 Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Prolonged ERK activation events R-HSA-169893 Frs2-mediated activation R-HSA-170968 ARMS-mediated activation R-HSA-170984 Signaling by EGFR R-HSA-177929 GRB2 events in EGFR signaling R-HSA-179812 SHC1 events in EGFR signaling R-HSA-180336 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signalling to p38 via RIT and RIN R-HSA-187706 Signaling by FGFR R-HSA-190236 Signaling by VEGF R-HSA-194138 GRB2 events in ERBB2 signaling R-HSA-1963640 DAP12 interactions R-HSA-2172127 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Signaling by Leptin R-HSA-2586552 FCERI mediated MAPK activation R-HSA-2871796 RMTs methylate histone arginines R-HSA-3214858 Chromatin modifying enzymes R-HSA-3247509 Signaling by GPCR R-HSA-372790 NCAM signaling for neurite out-growth R-HSA-375165 GPCR downstream signaling R-HSA-388396 G beta:gamma signalling through PI3Kgamma R-HSA-392451 G-protein beta:gamma signalling R-HSA-397795 Axon guidance R-HSA-422475 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signaling by Interleukins R-HSA-449147 Interleukin-2 signaling R-HSA-451927 Chromatin organization R-HSA-4839726 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 VEGFR2 mediated cell proliferation R-HSA-5218921 Downstream signaling of activated FGFR1 R-HSA-5654687 FRS-mediated FGFR1 signaling R-HSA-5654693 Downstream signaling of activated FGFR2 R-HSA-5654696 FRS-mediated FGFR2 signaling R-HSA-5654700 FRS-mediated FGFR3 signaling R-HSA-5654706 Downstream signaling of activated FGFR3 R-HSA-5654708 FRS-mediated FGFR4 signaling R-HSA-5654712 Downstream signaling of activated FGFR4 R-HSA-5654716 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 RAF activation R-HSA-5673000 RAF/MAP kinase cascade R-HSA-5673001 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Platelet activation, signaling and aggregation R-HSA-76002 Interferon gamma signaling R-HSA-877300 Regulation of IFNG signaling R-HSA-877312 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 Interleukin receptor SHC signaling R-HSA-912526 Interferon Signaling R-HSA-913531 Growth hormone receptor signaling R-HSA-982772 Factors involved in megakaryocyte development and platelet production R-HSA-983231",nucleus GO:0005634 10502458 19783980 IDA nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 10502458 IDA cytosol GO:0005829 TAS cytoskeleton GO:0005856 IEA caveola GO:0005901 ISS nuclear matrix GO:0016363 IEA extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA endosome lumen GO:0031904 TAS membrane raft GO:0045121 ISS,"GO:0000165 MAPK cascade TAS GO:0000186 activation of MAPKK activity IEA GO:0002250 adaptive immune response IEA 9670957 GO:0006468 protein phosphorylation TAS GO:0006915 apoptotic process ISS GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS 9670957 GO:0006928 movement of cell or subcellular component TAS GO:0007165 signal transduction ISS GO:0007167 enzyme linked receptor protein signaling pathway ISS GO:0007186 G-protein coupled receptor signaling pathway IEA GO:0007204 positive regulation of cytosolic calcium ion concentration IEA 9670957 GO:0007259 JAK-STAT cascade TAS GO:0007260 tyrosine phosphorylation of STAT protein IBA GO:0007260 tyrosine phosphorylation of STAT protein ISS GO:0007262 STAT protein import into nucleus ISS 9590174 GO:0007498 mesoderm development TAS GO:0007596 blood coagulation TAS GO:0008284 positive regulation of cell proliferation IEA GO:0008285 negative regulation of cell proliferation ISS GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IEA GO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA 10925297 GO:0010811 positive regulation of cell-substrate adhesion IDA GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS GO:0016477 cell migration IBA GO:0018108 peptidyl-tyrosine phosphorylation ISS 8609418 GO:0019221 cytokine-mediated signaling pathway IDA GO:0019221 cytokine-mediated signaling pathway ISS GO:0022408 negative regulation of cell-cell adhesion IEA 10925297 GO:0030041 actin filament polymerization NAS GO:0030154 cell differentiation ISS GO:0030218 erythrocyte differentiation IBA GO:0030218 erythrocyte differentiation ISS GO:0030335 positive regulation of cell migration IEA GO:0031103 axon regeneration IEA GO:0031959 mineralocorticoid receptor signaling pathway IEA GO:0032024 positive regulation of insulin secretion IEA GO:0032496 response to lipopolysaccharide ISS GO:0032516 positive regulation of phosphoprotein phosphatase activity IEA GO:0032731 positive regulation of interleukin-1 beta production IEA GO:0032760 positive regulation of tumor necrosis factor production ISS GO:0033160 positive regulation of protein import into nucleus, translocation IEA GO:0033194 response to hydroperoxide IEA 8609418 GO:0033209 tumor necrosis factor-mediated signaling pathway IDA 8609418 GO:0034612 response to tumor necrosis factor IDA 19783980 GO:0035409 histone H3-Y41 phosphorylation IDA GO:0035556 intracellular signal transduction ISS 7528775 GO:0035722 interleukin-12-mediated signaling pathway IDA GO:0038083 peptidyl-tyrosine autophosphorylation IBA GO:0042127 regulation of cell proliferation IBA GO:0042503 tyrosine phosphorylation of Stat3 protein IEA GO:0042506 tyrosine phosphorylation of Stat5 protein IEA GO:0042508 tyrosine phosphorylation of Stat1 protein IEA GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein ISS GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein ISS GO:0042977 activation of JAK2 kinase activity ISS GO:0042981 regulation of apoptotic process IBA GO:0043388 positive regulation of DNA binding IEA GO:0043392 negative regulation of DNA binding ISS GO:0043524 negative regulation of neuron apoptotic process IEA GO:0043547 positive regulation of GTPase activity IEA GO:0045087 innate immune response IBA GO:0045429 positive regulation of nitric oxide biosynthetic process IEA GO:0045597 positive regulation of cell differentiation IEA GO:0045822 negative regulation of heart contraction IEA 16280321 GO:0046677 response to antibiotic IDA GO:0046777 protein autophosphorylation ISS GO:0048008 platelet-derived growth factor receptor signaling pathway IEA 10925297 GO:0050727 regulation of inflammatory response IDA GO:0050729 positive regulation of inflammatory response IEA GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISS GO:0050867 positive regulation of cell activation IEA GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IEA GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process ISS GO:0060333 interferon-gamma-mediated signaling pathway TAS GO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS 10925297 GO:0060396 growth hormone receptor signaling pathway IDA GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway ISS GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway TAS GO:0060399 positive regulation of growth hormone receptor signaling pathway ISS GO:0061180 mammary gland epithelium development ISS 7528775 GO:0070671 response to interleukin-12 IDA GO:0097191 extrinsic apoptotic signaling pathway ISS GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISS",GO:0004672 protein kinase activity 9670957 NAS GO:0004713 protein tyrosine kinase activity 9111318 15143187 20304997 EXP GO:0004713 protein tyrosine kinase activity 23061660 IDA GO:0004713 protein tyrosine kinase activity ISS GO:0004713 protein tyrosine kinase activity TAS GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS GO:0005102 receptor binding 11201744 IPI GO:0005131 growth hormone receptor binding IBA GO:0005131 growth hormone receptor binding ISS GO:0005143 interleukin-12 receptor binding ISS GO:0005515 protein binding 11679576 11694501 11970898 15821101 16437163 17474147 18692472 21806020 24931576 IPI GO:0005524 ATP binding IEA GO:0008022 protein C-terminus binding IEA GO:0019901 protein kinase binding 10925297 IDA GO:0020037 heme binding 21036157 IDA GO:0031702 type 1 angiotensin receptor binding IEA GO:0033130 acetylcholine receptor binding IEA GO:0035401 histone kinase activity (H3-Y41 specific) 19783980 IDA GO:0042169 SH2 domain binding 9727029 IPI GO:0042393 histone binding 19783980 IDA GO:0043548 phosphatidylinositol 3-kinase binding IEA GO:0043560 insulin receptor substrate binding IEA GO:0046872 metal ion binding IEA GO:0051428 peptide hormone receptor binding IEA,hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) hsa05140 Leishmaniasis - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05152 Tuberculosis - Homo sapiens (human) hsa05162 Measles - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05168 Herpes simplex infection - Homo sapiens (human),chemicalprobes.org Tofacitinib,O60674,Tyrosine-protein kinase JAK2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,3717,JAK2,"Interleukin-6 signaling R-HSA-1059683 Hemostasis R-HSA-109582 MAPK3 (ERK1) activation R-HSA-110056 IRS-mediated signalling R-HSA-112399 RAF-independent MAPK1/3 activation R-HSA-112409 MAPK1 (ERK2) activation R-HSA-112411 SOS-mediated signalling R-HSA-112412 GPVI-mediated activation cascade R-HSA-114604 Prolactin receptor signaling R-HSA-1170546 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 SHC1 events in ERBB2 signaling R-HSA-1250196 SHC1 events in ERBB4 signaling R-HSA-1250347 Nuclear signaling by ERBB4 R-HSA-1251985 Developmental Biology R-HSA-1266738 Cytokine Signaling in Immune system R-HSA-1280215 Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Prolonged ERK activation events R-HSA-169893 Frs2-mediated activation R-HSA-170968 ARMS-mediated activation R-HSA-170984 Signaling by EGFR R-HSA-177929 GRB2 events in EGFR signaling R-HSA-179812 SHC1 events in EGFR signaling R-HSA-180336 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signalling to p38 via RIT and RIN R-HSA-187706 Signaling by FGFR R-HSA-190236 Signaling by VEGF R-HSA-194138 GRB2 events in ERBB2 signaling R-HSA-1963640 DAP12 interactions R-HSA-2172127 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Signaling by Leptin R-HSA-2586552 FCERI mediated MAPK activation R-HSA-2871796 RMTs methylate histone arginines R-HSA-3214858 Chromatin modifying enzymes R-HSA-3247509 Signaling by GPCR R-HSA-372790 NCAM signaling for neurite out-growth R-HSA-375165 GPCR downstream signaling R-HSA-388396 G beta:gamma signalling through PI3Kgamma R-HSA-392451 G-protein beta:gamma signalling R-HSA-397795 Axon guidance R-HSA-422475 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signaling by Interleukins R-HSA-449147 Interleukin-2 signaling R-HSA-451927 Chromatin organization R-HSA-4839726 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 VEGFR2 mediated cell proliferation R-HSA-5218921 Downstream signaling of activated FGFR1 R-HSA-5654687 FRS-mediated FGFR1 signaling R-HSA-5654693 Downstream signaling of activated FGFR2 R-HSA-5654696 FRS-mediated FGFR2 signaling R-HSA-5654700 FRS-mediated FGFR3 signaling R-HSA-5654706 Downstream signaling of activated FGFR3 R-HSA-5654708 FRS-mediated FGFR4 signaling R-HSA-5654712 Downstream signaling of activated FGFR4 R-HSA-5654716 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 RAF activation R-HSA-5673000 RAF/MAP kinase cascade R-HSA-5673001 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Platelet activation, signaling and aggregation R-HSA-76002 Interferon gamma signaling R-HSA-877300 Regulation of IFNG signaling R-HSA-877312 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 Interleukin receptor SHC signaling R-HSA-912526 Interferon Signaling R-HSA-913531 Growth hormone receptor signaling R-HSA-982772 Factors involved in megakaryocyte development and platelet production R-HSA-983231",nucleus GO:0005634 10502458 19783980 IDA nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 10502458 IDA cytosol GO:0005829 TAS cytoskeleton GO:0005856 IEA caveola GO:0005901 ISS nuclear matrix GO:0016363 IEA extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA endosome lumen GO:0031904 TAS membrane raft GO:0045121 ISS,"GO:0000165 MAPK cascade TAS GO:0000186 activation of MAPKK activity IEA GO:0002250 adaptive immune response IEA 9670957 GO:0006468 protein phosphorylation TAS GO:0006915 apoptotic process ISS GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS 9670957 GO:0006928 movement of cell or subcellular component TAS GO:0007165 signal transduction ISS GO:0007167 enzyme linked receptor protein signaling pathway ISS GO:0007186 G-protein coupled receptor signaling pathway IEA GO:0007204 positive regulation of cytosolic calcium ion concentration IEA 9670957 GO:0007259 JAK-STAT cascade TAS GO:0007260 tyrosine phosphorylation of STAT protein IBA GO:0007260 tyrosine phosphorylation of STAT protein ISS GO:0007262 STAT protein import into nucleus ISS 9590174 GO:0007498 mesoderm development TAS GO:0007596 blood coagulation TAS GO:0008284 positive regulation of cell proliferation IEA GO:0008285 negative regulation of cell proliferation ISS GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IEA GO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA 10925297 GO:0010811 positive regulation of cell-substrate adhesion IDA GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS GO:0016477 cell migration IBA GO:0018108 peptidyl-tyrosine phosphorylation ISS 8609418 GO:0019221 cytokine-mediated signaling pathway IDA GO:0019221 cytokine-mediated signaling pathway ISS GO:0022408 negative regulation of cell-cell adhesion IEA 10925297 GO:0030041 actin filament polymerization NAS GO:0030154 cell differentiation ISS GO:0030218 erythrocyte differentiation IBA GO:0030218 erythrocyte differentiation ISS GO:0030335 positive regulation of cell migration IEA GO:0031103 axon regeneration IEA GO:0031959 mineralocorticoid receptor signaling pathway IEA GO:0032024 positive regulation of insulin secretion IEA GO:0032496 response to lipopolysaccharide ISS GO:0032516 positive regulation of phosphoprotein phosphatase activity IEA GO:0032731 positive regulation of interleukin-1 beta production IEA GO:0032760 positive regulation of tumor necrosis factor production ISS GO:0033160 positive regulation of protein import into nucleus, translocation IEA GO:0033194 response to hydroperoxide IEA 8609418 GO:0033209 tumor necrosis factor-mediated signaling pathway IDA 8609418 GO:0034612 response to tumor necrosis factor IDA 19783980 GO:0035409 histone H3-Y41 phosphorylation IDA GO:0035556 intracellular signal transduction ISS 7528775 GO:0035722 interleukin-12-mediated signaling pathway IDA GO:0038083 peptidyl-tyrosine autophosphorylation IBA GO:0042127 regulation of cell proliferation IBA GO:0042503 tyrosine phosphorylation of Stat3 protein IEA GO:0042506 tyrosine phosphorylation of Stat5 protein IEA GO:0042508 tyrosine phosphorylation of Stat1 protein IEA GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein ISS GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein ISS GO:0042977 activation of JAK2 kinase activity ISS GO:0042981 regulation of apoptotic process IBA GO:0043388 positive regulation of DNA binding IEA GO:0043392 negative regulation of DNA binding ISS GO:0043524 negative regulation of neuron apoptotic process IEA GO:0043547 positive regulation of GTPase activity IEA GO:0045087 innate immune response IBA GO:0045429 positive regulation of nitric oxide biosynthetic process IEA GO:0045597 positive regulation of cell differentiation IEA GO:0045822 negative regulation of heart contraction IEA 16280321 GO:0046677 response to antibiotic IDA GO:0046777 protein autophosphorylation ISS GO:0048008 platelet-derived growth factor receptor signaling pathway IEA 10925297 GO:0050727 regulation of inflammatory response IDA GO:0050729 positive regulation of inflammatory response IEA GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISS GO:0050867 positive regulation of cell activation IEA GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IEA GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process ISS GO:0060333 interferon-gamma-mediated signaling pathway TAS GO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS 10925297 GO:0060396 growth hormone receptor signaling pathway IDA GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway ISS GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway TAS GO:0060399 positive regulation of growth hormone receptor signaling pathway ISS GO:0061180 mammary gland epithelium development ISS 7528775 GO:0070671 response to interleukin-12 IDA GO:0097191 extrinsic apoptotic signaling pathway ISS GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISS",GO:0004672 protein kinase activity 9670957 NAS GO:0004713 protein tyrosine kinase activity 9111318 15143187 20304997 EXP GO:0004713 protein tyrosine kinase activity 23061660 IDA GO:0004713 protein tyrosine kinase activity ISS GO:0004713 protein tyrosine kinase activity TAS GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS GO:0005102 receptor binding 11201744 IPI GO:0005131 growth hormone receptor binding IBA GO:0005131 growth hormone receptor binding ISS GO:0005143 interleukin-12 receptor binding ISS GO:0005515 protein binding 11679576 11694501 11970898 15821101 16437163 17474147 18692472 21806020 24931576 IPI GO:0005524 ATP binding IEA GO:0008022 protein C-terminus binding IEA GO:0019901 protein kinase binding 10925297 IDA GO:0020037 heme binding 21036157 IDA GO:0031702 type 1 angiotensin receptor binding IEA GO:0033130 acetylcholine receptor binding IEA GO:0035401 histone kinase activity (H3-Y41 specific) 19783980 IDA GO:0042169 SH2 domain binding 9727029 IPI GO:0042393 histone binding 19783980 IDA GO:0043548 phosphatidylinositol 3-kinase binding IEA GO:0043560 insulin receptor substrate binding IEA GO:0046872 metal ion binding IEA GO:0051428 peptide hormone receptor binding IEA,hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) hsa05140 Leishmaniasis - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05152 Tuberculosis - Homo sapiens (human) hsa05162 Measles - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05168 Herpes simplex infection - Homo sapiens (human),chemicalprobes.org BMS-911543,O60674,Tyrosine-protein kinase JAK2,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,3717,JAK2,"Interleukin-6 signaling R-HSA-1059683 Hemostasis R-HSA-109582 MAPK3 (ERK1) activation R-HSA-110056 IRS-mediated signalling R-HSA-112399 RAF-independent MAPK1/3 activation R-HSA-112409 MAPK1 (ERK2) activation R-HSA-112411 SOS-mediated signalling R-HSA-112412 GPVI-mediated activation cascade R-HSA-114604 Prolactin receptor signaling R-HSA-1170546 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 SHC1 events in ERBB2 signaling R-HSA-1250196 SHC1 events in ERBB4 signaling R-HSA-1250347 Nuclear signaling by ERBB4 R-HSA-1251985 Developmental Biology R-HSA-1266738 Cytokine Signaling in Immune system R-HSA-1280215 Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Prolonged ERK activation events R-HSA-169893 Frs2-mediated activation R-HSA-170968 ARMS-mediated activation R-HSA-170984 Signaling by EGFR R-HSA-177929 GRB2 events in EGFR signaling R-HSA-179812 SHC1 events in EGFR signaling R-HSA-180336 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signalling to p38 via RIT and RIN R-HSA-187706 Signaling by FGFR R-HSA-190236 Signaling by VEGF R-HSA-194138 GRB2 events in ERBB2 signaling R-HSA-1963640 DAP12 interactions R-HSA-2172127 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Signaling by Leptin R-HSA-2586552 FCERI mediated MAPK activation R-HSA-2871796 RMTs methylate histone arginines R-HSA-3214858 Chromatin modifying enzymes R-HSA-3247509 Signaling by GPCR R-HSA-372790 NCAM signaling for neurite out-growth R-HSA-375165 GPCR downstream signaling R-HSA-388396 G beta:gamma signalling through PI3Kgamma R-HSA-392451 G-protein beta:gamma signalling R-HSA-397795 Axon guidance R-HSA-422475 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signaling by Interleukins R-HSA-449147 Interleukin-2 signaling R-HSA-451927 Chromatin organization R-HSA-4839726 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 VEGFR2 mediated cell proliferation R-HSA-5218921 Downstream signaling of activated FGFR1 R-HSA-5654687 FRS-mediated FGFR1 signaling R-HSA-5654693 Downstream signaling of activated FGFR2 R-HSA-5654696 FRS-mediated FGFR2 signaling R-HSA-5654700 FRS-mediated FGFR3 signaling R-HSA-5654706 Downstream signaling of activated FGFR3 R-HSA-5654708 FRS-mediated FGFR4 signaling R-HSA-5654712 Downstream signaling of activated FGFR4 R-HSA-5654716 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 RAF activation R-HSA-5673000 RAF/MAP kinase cascade R-HSA-5673001 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Platelet activation, signaling and aggregation R-HSA-76002 Interferon gamma signaling R-HSA-877300 Regulation of IFNG signaling R-HSA-877312 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 Interleukin receptor SHC signaling R-HSA-912526 Interferon Signaling R-HSA-913531 Growth hormone receptor signaling R-HSA-982772 Factors involved in megakaryocyte development and platelet production R-HSA-983231",nucleus GO:0005634 10502458 19783980 IDA nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 10502458 IDA cytosol GO:0005829 TAS cytoskeleton GO:0005856 IEA caveola GO:0005901 ISS nuclear matrix GO:0016363 IEA extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA endosome lumen GO:0031904 TAS membrane raft GO:0045121 ISS,"GO:0000165 MAPK cascade TAS GO:0000186 activation of MAPKK activity IEA GO:0002250 adaptive immune response IEA 9670957 GO:0006468 protein phosphorylation TAS GO:0006915 apoptotic process ISS GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS 9670957 GO:0006928 movement of cell or subcellular component TAS GO:0007165 signal transduction ISS GO:0007167 enzyme linked receptor protein signaling pathway ISS GO:0007186 G-protein coupled receptor signaling pathway IEA GO:0007204 positive regulation of cytosolic calcium ion concentration IEA 9670957 GO:0007259 JAK-STAT cascade TAS GO:0007260 tyrosine phosphorylation of STAT protein IBA GO:0007260 tyrosine phosphorylation of STAT protein ISS GO:0007262 STAT protein import into nucleus ISS 9590174 GO:0007498 mesoderm development TAS GO:0007596 blood coagulation TAS GO:0008284 positive regulation of cell proliferation IEA GO:0008285 negative regulation of cell proliferation ISS GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IEA GO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA 10925297 GO:0010811 positive regulation of cell-substrate adhesion IDA GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS GO:0016477 cell migration IBA GO:0018108 peptidyl-tyrosine phosphorylation ISS 8609418 GO:0019221 cytokine-mediated signaling pathway IDA GO:0019221 cytokine-mediated signaling pathway ISS GO:0022408 negative regulation of cell-cell adhesion IEA 10925297 GO:0030041 actin filament polymerization NAS GO:0030154 cell differentiation ISS GO:0030218 erythrocyte differentiation IBA GO:0030218 erythrocyte differentiation ISS GO:0030335 positive regulation of cell migration IEA GO:0031103 axon regeneration IEA GO:0031959 mineralocorticoid receptor signaling pathway IEA GO:0032024 positive regulation of insulin secretion IEA GO:0032496 response to lipopolysaccharide ISS GO:0032516 positive regulation of phosphoprotein phosphatase activity IEA GO:0032731 positive regulation of interleukin-1 beta production IEA GO:0032760 positive regulation of tumor necrosis factor production ISS GO:0033160 positive regulation of protein import into nucleus, translocation IEA GO:0033194 response to hydroperoxide IEA 8609418 GO:0033209 tumor necrosis factor-mediated signaling pathway IDA 8609418 GO:0034612 response to tumor necrosis factor IDA 19783980 GO:0035409 histone H3-Y41 phosphorylation IDA GO:0035556 intracellular signal transduction ISS 7528775 GO:0035722 interleukin-12-mediated signaling pathway IDA GO:0038083 peptidyl-tyrosine autophosphorylation IBA GO:0042127 regulation of cell proliferation IBA GO:0042503 tyrosine phosphorylation of Stat3 protein IEA GO:0042506 tyrosine phosphorylation of Stat5 protein IEA GO:0042508 tyrosine phosphorylation of Stat1 protein IEA GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein ISS GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein ISS GO:0042977 activation of JAK2 kinase activity ISS GO:0042981 regulation of apoptotic process IBA GO:0043388 positive regulation of DNA binding IEA GO:0043392 negative regulation of DNA binding ISS GO:0043524 negative regulation of neuron apoptotic process IEA GO:0043547 positive regulation of GTPase activity IEA GO:0045087 innate immune response IBA GO:0045429 positive regulation of nitric oxide biosynthetic process IEA GO:0045597 positive regulation of cell differentiation IEA GO:0045822 negative regulation of heart contraction IEA 16280321 GO:0046677 response to antibiotic IDA GO:0046777 protein autophosphorylation ISS GO:0048008 platelet-derived growth factor receptor signaling pathway IEA 10925297 GO:0050727 regulation of inflammatory response IDA GO:0050729 positive regulation of inflammatory response IEA GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISS GO:0050867 positive regulation of cell activation IEA GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IEA GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process ISS GO:0060333 interferon-gamma-mediated signaling pathway TAS GO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS 10925297 GO:0060396 growth hormone receptor signaling pathway IDA GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway ISS GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway TAS GO:0060399 positive regulation of growth hormone receptor signaling pathway ISS GO:0061180 mammary gland epithelium development ISS 7528775 GO:0070671 response to interleukin-12 IDA GO:0097191 extrinsic apoptotic signaling pathway ISS GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISS",GO:0004672 protein kinase activity 9670957 NAS GO:0004713 protein tyrosine kinase activity 9111318 15143187 20304997 EXP GO:0004713 protein tyrosine kinase activity 23061660 IDA GO:0004713 protein tyrosine kinase activity ISS GO:0004713 protein tyrosine kinase activity TAS GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS GO:0005102 receptor binding 11201744 IPI GO:0005131 growth hormone receptor binding IBA GO:0005131 growth hormone receptor binding ISS GO:0005143 interleukin-12 receptor binding ISS GO:0005515 protein binding 11679576 11694501 11970898 15821101 16437163 17474147 18692472 21806020 24931576 IPI GO:0005524 ATP binding IEA GO:0008022 protein C-terminus binding IEA GO:0019901 protein kinase binding 10925297 IDA GO:0020037 heme binding 21036157 IDA GO:0031702 type 1 angiotensin receptor binding IEA GO:0033130 acetylcholine receptor binding IEA GO:0035401 histone kinase activity (H3-Y41 specific) 19783980 IDA GO:0042169 SH2 domain binding 9727029 IPI GO:0042393 histone binding 19783980 IDA GO:0043548 phosphatidylinositol 3-kinase binding IEA GO:0043560 insulin receptor substrate binding IEA GO:0046872 metal ion binding IEA GO:0051428 peptide hormone receptor binding IEA,hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) hsa05140 Leishmaniasis - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05152 Tuberculosis - Homo sapiens (human) hsa05162 Measles - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05168 Herpes simplex infection - Homo sapiens (human),chemicalprobes.org Tofacitinib,P52333,Tyrosine-protein kinase JAK3,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,3718,JAK3,"R-HSA-109582 Hemostasis R-HSA-112399 IRS-mediated signalling R-HSA-112412 SOS-mediated signalling R-HSA-114604 GPVI-mediated activation cascade R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250196 SHC1 events in ERBB2 signaling R-HSA-1250347 SHC1 events in ERBB4 signaling R-HSA-1266695 Interleukin-7 signaling R-HSA-1266738 Developmental Biology R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1433557 Signaling by SCF-KIT R-HSA-162582 Signal Transduction R-HSA-166520 Signalling by NGF R-HSA-167044 Signalling to RAS R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-169893 Prolonged ERK activation events R-HSA-170968 Frs2-mediated activation R-HSA-170984 ARMS-mediated activation R-HSA-177929 Signaling by EGFR R-HSA-179812 GRB2 events in EGFR signaling R-HSA-180336 SHC1 events in EGFR signaling R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-187687 Signalling to ERKs R-HSA-187706 Signalling to p38 via RIT and RIN R-HSA-190236 Signaling by FGFR R-HSA-194138 Signaling by VEGF R-HSA-1963640 GRB2 events in ERBB2 signaling R-HSA-2172127 DAP12 interactions R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2586552 Signaling by Leptin R-HSA-2871796 FCERI mediated MAPK activation R-HSA-372790 Signaling by GPCR R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-388396 GPCR downstream signaling R-HSA-392451 G beta:gamma signalling through PI3Kgamma R-HSA-397795 G-protein beta:gamma signalling R-HSA-422475 Axon guidance R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5683057 MAPK family signaling cascades R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-912526 Interleukin receptor SHC signaling",cytosol TAS GO:0005829 cytoskeleton IEA GO:0005856 endomembrane system IEA GO:0012505 extrinsic component of cytoplasmic side of plasma membrane IBA GO:0031234,MAPK cascade GO:0000165 TAS adaptive immune response GO:0002250 IEA negative regulation of dendritic cell cytokine production GO:0002731 ISS protein phosphorylation GO:0006468 TAS 8022790 enzyme linked receptor protein signaling pathway GO:0007167 ISS positive regulation of cytosolic calcium ion concentration GO:0007204 IEA tyrosine phosphorylation of STAT protein GO:0007260 TAS 19290934 STAT protein import into nucleus GO:0007262 TAS 19290934 cell migration GO:0016477 IBA peptidyl-tyrosine phosphorylation GO:0018108 ISS B cell differentiation GO:0030183 IBA B cell differentiation GO:0030183 ISS negative regulation of interleukin-10 production GO:0032693 ISS negative regulation of interleukin-12 production GO:0032695 ISS intracellular signal transduction GO:0035556 ISS interleukin-4-mediated signaling pathway GO:0035771 IDA 7538655 peptidyl-tyrosine autophosphorylation GO:0038083 IBA positive regulation of T cell proliferation GO:0042102 IBA positive regulation of activated T cell proliferation GO:0042104 IEA tyrosine phosphorylation of Stat5 protein GO:0042506 IEA T cell homeostasis GO:0043029 ISS T cell homeostasis GO:0043029 TAS 19290934 positive regulation of GTPase activity GO:0043547 IEA innate immune response GO:0045087 IBA negative regulation of FasL biosynthetic process GO:0045221 ISS negative regulation of T-helper 1 cell differentiation GO:0045626 ISS positive regulation of immune response GO:0050778 IEA negative regulation of T cell activation GO:0050868 ISS positive regulation of calcium ion transport GO:0051928 IEA JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 TAS 19290934 regulation of T cell apoptotic process GO:0070232 ISS negative regulation of thymocyte apoptotic process GO:0070244 ISS response to interleukin-2 GO:0070669 TAS 9973401 response to interleukin-4 GO:0070670 IDA 7538655 7594533 response to interleukin-15 GO:0070672 TAS 7594533 response to interleukin-9 GO:0071104 TAS 7594533,ISS GO:0004713 protein tyrosine kinase activity TAS GO:0004713 protein tyrosine kinase activity IBA GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS GO:0005088 Ras guanyl-nucleotide exchange factor activity IBA GO:0005102 receptor binding 9045636 25852190 IPI GO:0005515 protein binding IEA GO:0005524 ATP binding 11909529 IPI GO:0019903 protein phosphatase binding,Chemokine signaling pathway - Homo sapiens (human) hsa04062 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04550 Jak-STAT signaling pathway - Homo sapiens (human) hsa04630 Measles - Homo sapiens (human) hsa05162 HTLV-I infection - Homo sapiens (human) hsa05166 Epstein-Barr virus infection - Homo sapiens (human) hsa05169 Viral carcinogenesis - Homo sapiens (human) hsa05203 Primary immunodeficiency - Homo sapiens (human) hsa05340,chemicalprobes.org WH-4-023,P06239,Tyrosine-protein kinase LCK,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,3932,LCK,"R-HSA-109582 Hemostasis R-HSA-114604 GPVI-mediated activation cascade R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-1433557 Signaling by SCF-KIT R-HSA-1433559 Regulation of KIT signaling R-HSA-162582 Signal Transduction R-HSA-162906 HIV Infection R-HSA-162909 Host Interactions of HIV factors R-HSA-1643685 Disease R-HSA-164938 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters R-HSA-164944 Nef and signal transduction R-HSA-164952 The role of Nef in HIV-1 replication and disease pathogenesis R-HSA-166520 Signalling by NGF R-HSA-167590 Nef Mediated CD4 Down-regulation R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-177929 Signaling by EGFR R-HSA-180292 GAB1 signalosome R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-190236 Signaling by FGFR R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-202403 TCR signaling R-HSA-202424 Downstream TCR signaling R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains R-HSA-202430 Translocation of ZAP-70 to Immunological synapse R-HSA-202433 Generation of second messenger molecules R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-210990 PECAM1 interactions R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2424491 DAP12 signaling R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-388841 Costimulation by the CD28 family R-HSA-389356 CD28 co-stimulation R-HSA-389357 CD28 dependent PI3K/Akt signaling R-HSA-389359 CD28 dependent Vav1 pathway R-HSA-389513 CTLA4 inhibitory signaling R-HSA-389948 PD-1 signaling R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5663202 Diseases of signal transduction R-HSA-5663205 Infectious disease R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-983705 Signaling by the B Cell Receptor (BCR)",pericentriolar material GO:0000242 IDA 7513706 pericentriolar material GO:0000242 ISS immunological synapse GO:0001772 IDA 20007709 cytosol GO:0005829 TAS plasma membrane GO:0005886 IDA 12150984 plasma membrane GO:0005886 TAS extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA membrane raft GO:0045121 IDA 12150984 12732664 membrane raft GO:0045121 ISS extracellular exosome GO:0070062 IDA 20458337 23376485,protein phosphorylation 214242 GO:0006468 IDA protein dephosphorylation GO:0006470 IEA cellular zinc ion homeostasis 11739864 GO:0006882 IEP cellular zinc ion homeostasis GO:0006882 ISS activation of cysteine-type endopeptidase activity involved in apoptotic process 16116473 GO:0006919 IDA activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 ISS transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA regulation of phosphatidylinositol 3-kinase signaling GO:0014066 TAS viral process GO:0016032 IEA hemopoiesis 12884910 GO:0030097 NAS platelet activation GO:0030168 TAS T cell differentiation 1579166 GO:0030217 IMP T cell differentiation GO:0030217 ISS T cell costimulation GO:0031295 TAS peptidyl-tyrosine autophosphorylation GO:0038083 IBA regulation of cell proliferation GO:0042127 IBA response to drug 16116473 GO:0042493 IDA response to drug GO:0042493 ISS innate immune response GO:0045087 IBA phosphatidylinositol phosphorylation GO:0046854 IEA phosphatidylinositol-mediated signaling GO:0048015 TAS regulation of defense response to virus by virus GO:0050690 TAS T cell receptor signaling pathway GO:0050852 TAS B cell receptor signaling pathway GO:0050853 IBA positive regulation of T cell receptor signaling pathway 12614355 GO:0050862 NAS positive regulation of T cell activation 8943371 GO:0050870 IDA positive regulation of T cell activation GO:0050870 ISS leukocyte migration GO:0050900 TAS release of sequestered calcium ion into cytosol GO:0051209 ISS regulation of lymphocyte activation 7852312 GO:0051249 NAS positive regulation of intrinsic apoptotic signaling pathway 16116473 GO:2001244 IMP positive regulation of intrinsic apoptotic signaling pathway GO:2001244 ISS,"glycoprotein binding 7513706 8650207 14625311 15554700 GO:0001948 IPI protein tyrosine kinase activity 1381360 9799234 12923167 18697750 GO:0004713 EXP protein tyrosine kinase activity 214242 GO:0004713 IDA protein tyrosine kinase activity GO:0004713 ISS protein tyrosine kinase activity GO:0004713 TAS non-membrane spanning protein tyrosine kinase activity GO:0004715 IBA protein serine/threonine phosphatase activity 8506364 GO:0004722 IDA protein serine/threonine phosphatase activity GO:0004722 ISS protein binding 7507203 7852312 8114715 8576115 8798676 9045636 9175835 9341123 10209036 10318843 10369126 10553045 10656681 11278465 11741929 14757743 15536084 15827961 16051843 16099425 16107303 16195219 16245368 16461343 16839418 16888650 16899217 16938345 17005671 17382937 18424730 18539162 19167335 19192391 20100835 21719704 21964608 22939624 24728074 25416956 GO:0005515 IPI ATP binding GO:0005524 IEA protein C-terminus binding 16245368 GO:0008022 IPI kinase activity GO:0016301 TAS protein kinase binding 8618896 GO:0019901 IPI protein phosphatase binding 22080863 GO:0019903 IPI SH2 domain binding 7852312 8794306 GO:0042169 IPI SH2 domain binding GO:0042169 ISS CD4 receptor binding 7486703 GO:0042609 IPI CD8 receptor binding 2470098 GO:0042610 IPI identical protein binding 17118402 GO:0042802 IPI phosphatidylinositol 3-kinase binding 7504174 GO:0043548 IPI phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 TAS ATPase binding 15671290 GO:0051117 IPI",NF-kappa B signaling pathway - Homo sapiens (human) hsa04064 Osteoclast differentiation - Homo sapiens (human) hsa04380 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04650 T cell receptor signaling pathway - Homo sapiens (human) hsa04660 HTLV-I infection - Homo sapiens (human) hsa05166 Primary immunodeficiency - Homo sapiens (human) hsa05340,chemicalprobes.org Bafetinib,P07948,Tyrosine-protein kinase Lyn,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,4067,LYN,"R-HSA-109582 Hemostasis R-HSA-114604 GPVI-mediated activation cascade R-HSA-1266738 Developmental Biology R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-1433557 Signaling by SCF-KIT R-HSA-1433559 Regulation of KIT signaling R-HSA-162582 Signal Transduction R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-210990 PECAM1 interactions R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2682334 EPH-Ephrin signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-388841 Costimulation by the CD28 family R-HSA-389356 CD28 co-stimulation R-HSA-389513 CTLA4 inhibitory signaling R-HSA-3928662 EPHB-mediated forward signaling R-HSA-3928663 EPHA-mediated growth cone collapse R-HSA-3928665 EPH-ephrin mediated repulsion of cells R-HSA-422475 Axon guidance R-HSA-449147 Signaling by Interleukins R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-5621480 Dectin-2 family R-HSA-5621481 C-type lectin receptors (CLRs) R-HSA-75892 Platelet Adhesion to exposed collagen R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-912631 Regulation of signaling by CBL R-HSA-982772 Growth hormone receptor signaling",nucleus IDA 18817770 GO:0005634 nucleus ISS GO:0005634 cytoplasm ISS GO:0005737 mitochondrial intermembrane space IEA GO:0005758 Golgi apparatus IDA 15173188 20605918 GO:0005794 cytosol TAS GO:0005829 plasma membrane IDA 15173188 20605918 GO:0005886 plasma membrane TAS GO:0005886 cell-cell adherens junction IEA GO:0005913 postsynaptic density IEA GO:0014069 mitochondrial crista IEA GO:0030061 extrinsic component of cytoplasmic side of plasma membrane IBA GO:0031234 integrin alpha2-beta1 complex IEA GO:0034666 mast cell granule IEA GO:0042629 membrane raft IDA 11313396 GO:0045121 perinuclear region of cytoplasm IDA 20605918 GO:0048471 extracellular exosome IDA 23376485 23533145 GO:0070062,ISS GO:0001782 B cell homeostasis ISS GO:0001817 regulation of cytokine production TAS 15489917 regulation of protein phosphorylation GO:0001932 ISS GO:0001933 negative regulation of protein phosphorylation TAS GO:0002223 stimulatory C-type lectin receptor signaling pathway IEA GO:0002250 adaptive immune response IBA GO:0002431 Fc receptor mediated stimulatory signaling pathway ISS GO:0002431 Fc receptor mediated stimulatory signaling pathway ISS GO:0002513 tolerance induction to self antigen TAS 15489917 tolerance induction to self antigen GO:0002513 IEA GO:0002553 histamine secretion by mast cell IBA GO:0002576 platelet degranulation ISS GO:0002576 platelet degranulation IEA GO:0002762 negative regulation of myeloid leukocyte differentiation ISS GO:0002768 immune response-regulating cell surface receptor signaling pathway TAS 15489917 immune response-regulating cell surface receptor signaling pathway GO:0002768 ISS GO:0002774 Fc receptor mediated inhibitory signaling pathway IBA GO:0002902 regulation of B cell apoptotic process IDA 11517336 protein phosphorylation GO:0006468 IBA GO:0006954 inflammatory response IDA 10891478 11517336 cellular response to DNA damage stimulus GO:0006974 IEA GO:0006991 response to sterol depletion TAS 7650013 signal transduction GO:0007165 IMP 14726379 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IBA GO:0007417 central nervous system development TAS GO:0007596 blood coagulation ISS GO:0008284 positive regulation of cell proliferation IMP 14726379 negative regulation of cell proliferation GO:0008285 IEA GO:0009636 response to toxic substance ISS GO:0009725 response to hormone IEA GO:0009743 response to carbohydrate IMP 17910947 positive regulation of neuron projection development GO:0010976 IEA GO:0014003 oligodendrocyte development IEA GO:0014070 response to organic cyclic compound IEA GO:0016032 viral process IDA 7682714 peptidyl-tyrosine phosphorylation GO:0018108 IEA GO:0023014 signal transduction by protein phosphorylation TAS GO:0030168 platelet activation ISS GO:0030218 erythrocyte differentiation IEA GO:0030335 positive regulation of cell migration IBA GO:0030889 negative regulation of B cell proliferation IEA GO:0031175 neuron projection development TAS GO:0031295 T cell costimulation ISS GO:0031663 lipopolysaccharide-mediated signaling pathway IEA GO:0031668 cellular response to extracellular stimulus IEA GO:0032868 response to insulin ISS GO:0033003 regulation of mast cell activation IMP 18802065 regulation of cell adhesion mediated by integrin GO:0033628 ISS GO:0034136 negative regulation of toll-like receptor 2 signaling pathway ISS GO:0034144 negative regulation of toll-like receptor 4 signaling pathway IEA GO:0034605 cellular response to heat IBA GO:0038083 peptidyl-tyrosine autophosphorylation TAS GO:0038095 Fc-epsilon receptor signaling pathway TAS GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis IEA GO:0042493 response to drug ISS GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA GO:0043200 response to amino acid IBA GO:0043304 regulation of mast cell degranulation ISS GO:0043304 regulation of mast cell degranulation ISS GO:0043407 negative regulation of MAP kinase activity IEA GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IBA GO:0045087 innate immune response ISS GO:0045646 regulation of erythrocyte differentiation IDA 7682714 protein autophosphorylation GO:0046777 TAS GO:0048013 ephrin receptor signaling pathway IEA GO:0048678 response to axon injury IEA GO:0050663 cytokine secretion IEA GO:0050707 regulation of cytokine secretion IEA GO:0050727 regulation of inflammatory response TAS 15489917 negative regulation of immune response GO:0050777 IEA GO:0050853 B cell receptor signaling pathway IBA GO:0050855 regulation of B cell receptor signaling pathway ISS GO:0050855 regulation of B cell receptor signaling pathway IEA GO:0050861 positive regulation of B cell receptor signaling pathway TAS GO:0050900 leukocyte migration IDA 16467205 positive regulation of cellular component movement GO:0051272 IEA GO:0051279 regulation of release of sequestered calcium ion into cytosol IEA GO:0060252 positive regulation of glial cell proliferation IEA GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway TAS GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway IDA 10891478 positive regulation of stress-activated protein kinase signaling cascade GO:0070304 ISS GO:0070372 regulation of ERK1 and ERK2 cascade ISS GO:0070373 negative regulation of ERK1 and ERK2 cascade IEA GO:0070447 positive regulation of oligodendrocyte progenitor proliferation IBA GO:0070667 negative regulation of mast cell proliferation ISS GO:0070667 negative regulation of mast cell proliferation IMP 11435302 positive regulation of mast cell proliferation GO:0070668 IMP 17910947 cellular response to retinoic acid GO:0071300 IMP 18802065 regulation of monocyte chemotaxis GO:0090025 IBA GO:0090330 regulation of platelet aggregation ISS GO:0090330 regulation of platelet aggregation IBA GO:0097028 dendritic cell differentiation ISS GO:0097028 dendritic cell differentiation ISS GO:1902532 negative regulation of intracellular signal transduction IBA GO:2000670 positive regulation of dendritic cell apoptotic process ISS GO:2000670 positive regulation of dendritic cell apoptotic process,1381360 7526393 9799234 10861086 11110698 11358993 11448999 12670955 12923167 16921024 17462920 18697750 EXP GO:0004713 protein tyrosine kinase activity 7682714 IDA GO:0004713 protein tyrosine kinase activity TAS GO:0004713 protein tyrosine kinase activity IBA GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS GO:0004715 non-membrane spanning protein tyrosine kinase activity 10748115 TAS GO:0004716 receptor signaling protein tyrosine kinase activity IBA GO:0005102 receptor binding IEA GO:0005161 platelet-derived growth factor receptor binding IEA GO:0005178 integrin binding 1715582 7859737 8647200 8753773 9020138 11306681 11517336 14993658 15546919 15784897 16155203 16799092 17254966 17640867 18070987 20159608 22581261 22624718 22731636 23001182 23764002 23866081 24658140 24728074 IPI GO:0005515 protein binding IEA GO:0005524 ATP binding IEA GO:0017124 SH3 domain binding IEA GO:0031625 ubiquitin protein ligase binding IEA GO:0043015 gamma-tubulin binding IEA GO:0043208 glycosphingolipid binding 12538589 IPI GO:0044325 ion channel binding IEA GO:0051219 phosphoprotein binding,Chemokine signaling pathway - Homo sapiens (human) hsa04062 NF-kappa B signaling pathway - Homo sapiens (human) hsa04064 Platelet activation - Homo sapiens (human) hsa04611 B cell receptor signaling pathway - Homo sapiens (human) hsa04662 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04664 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04666 Long-term depression - Homo sapiens (human) hsa04730 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) hsa05120 Epstein-Barr virus infection - Homo sapiens (human) hsa05169 Viral carcinogenesis - Homo sapiens (human) hsa05203,chemicalprobes.org AC220,P36888,Tyrosine-protein kinase receptor FLT3,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,2322,FLT3,,nucleus GO:0005634 IEA endoplasmic reticulum lumen GO:0005788 IEA cytosol GO:0005829 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane 8394751 GO:0005887 TAS protein complex GO:0043234 IEA,GO:0001776 leukocyte homeostasis ISS GO:0002318 myeloid progenitor cell differentiation ISS GO:0002328 pro-B cell differentiation ISS 7507245 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 19549778 GO:0008284 positive regulation of cell proliferation TAS GO:0010243 response to organonitrogen compound IEA 12951584 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling TAS 19549778 GO:0018108 peptidyl-tyrosine phosphorylation TAS GO:0019221 cytokine-mediated signaling pathway ISS 7507245 GO:0030097 hemopoiesis IDA GO:0030183 B cell differentiation ISS GO:0031100 organ regeneration IEA GO:0035726 common myeloid progenitor cell proliferation ISS GO:0038084 vascular endothelial growth factor signaling pathway IEA 19549778 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein TAS 19549778 GO:0042981 regulation of apoptotic process TAS 19549778 GO:0043406 positive regulation of MAP kinase activity TAS 19549778 GO:0043410 positive regulation of MAPK cascade TAS 12951584 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity TAS GO:0046651 lymphocyte proliferation ISS 19549778 GO:0046777 protein autophosphorylation TAS GO:0071345 cellular response to cytokine stimulus ISS 19549778 GO:0071345 cellular response to cytokine stimulus TAS GO:0071385 cellular response to glucocorticoid stimulus IEA GO:0097028 dendritic cell differentiation ISS,transmembrane receptor protein tyrosine kinase activity TAS 19549778 GO:0004714 cytokine receptor activity ISS GO:0004896 vascular endothelial growth factor-activated receptor activity TAS 8394751 GO:0005021 protein binding IPI 16982329 20098747 23650535 24525236 GO:0005515 ATP binding IEA GO:0005524 protein complex binding IEA GO:0032403 glucocorticoid receptor binding IEA GO:0035259 protein homodimerization activity TAS 19549778 GO:0042803,hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) hsa04640 Hematopoietic cell lineage - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) hsa05221 Acute myeloid leukemia - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human),chemicalprobes.org WH-4-023,P12931,Tyrosine-protein kinase SRC,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,6714,SRC,"Hemostasis R-HSA-109582 IRS-mediated signalling R-HSA-112399 SOS-mediated signalling R-HSA-112412 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 SHC1 events in ERBB2 signaling R-HSA-1250196 SHC1 events in ERBB4 signaling R-HSA-1250347 Developmental Biology R-HSA-1266738 Cytokine Signaling in Immune system R-HSA-1280215 Adaptive Immune System R-HSA-1280218 Spry regulation of FGF signaling R-HSA-1295596 Signaling by SCF-KIT R-HSA-1433557 Regulation of KIT signaling R-HSA-1433559 Cell-Cell communication R-HSA-1500931 Gap junction trafficking and regulation R-HSA-157858 Signal Transduction R-HSA-162582 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Prolonged ERK activation events R-HSA-169893 Frs2-mediated activation R-HSA-170968 ARMS-mediated activation R-HSA-170984 p38MAPK events R-HSA-171007 Signaling by EGFR R-HSA-177929 GRB2 events in EGFR signaling R-HSA-179812 GAB1 signalosome R-HSA-180292 SHC1 events in EGFR signaling R-HSA-180336 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signalling to p38 via RIT and RIN R-HSA-187706 Signaling by FGFR R-HSA-190236 c-src mediated regulation of Cx43 function and closure of gap junctions R-HSA-191647 Regulation of gap junction activity R-HSA-191650 Signaling by VEGF R-HSA-194138 Signaling by Rho GTPases R-HSA-194315 RHO GTPase Effectors R-HSA-195258 GRB2 events in ERBB2 signaling R-HSA-1963640 Membrane Trafficking R-HSA-199991 Cell surface interactions at the vascular wall R-HSA-202733 PECAM1 interactions R-HSA-210990 DAP12 interactions R-HSA-2172127 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Signaling by Leptin R-HSA-2586552 EPH-Ephrin signaling R-HSA-2682334 FCERI mediated MAPK activation R-HSA-2871796 Integrin alphaIIb beta3 signaling R-HSA-354192 GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 p130Cas linkage to MAPK signaling for integrins R-HSA-372708 Signaling by GPCR R-HSA-372790 Netrin-1 signaling R-HSA-373752 L1CAM interactions R-HSA-373760 NCAM signaling for neurite out-growth R-HSA-375165 Costimulation by the CD28 family R-HSA-388841 CD28 co-stimulation R-HSA-389356 CTLA4 inhibitory signaling R-HSA-389513 Signal regulatory protein (SIRP) family interactions R-HSA-391160 EPHB-mediated forward signaling R-HSA-3928662 EPHA-mediated growth cone collapse R-HSA-3928663 Ephrin signaling R-HSA-3928664 EPH-ephrin mediated repulsion of cells R-HSA-3928665 DCC mediated attractive signaling R-HSA-418885 Netrin mediated repulsion signals R-HSA-418886 Axon guidance R-HSA-422475 GP1b-IX-V activation signalling R-HSA-430116 Recycling pathway of L1 R-HSA-437239 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signaling by Interleukins R-HSA-449147 Interleukin-2 signaling R-HSA-451927 Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 VEGFR2 mediated cell proliferation R-HSA-5218921 CLEC7A (Dectin-1) signaling R-HSA-5607764 C-type lectin receptors (CLRs) R-HSA-5621481 Vesicle-mediated transport R-HSA-5653656 Downstream signaling of activated FGFR1 R-HSA-5654687 FRS-mediated FGFR1 signaling R-HSA-5654693 Downstream signaling of activated FGFR2 R-HSA-5654696 FRS-mediated FGFR2 signaling R-HSA-5654700 FRS-mediated FGFR3 signaling R-HSA-5654706 Downstream signaling of activated FGFR3 R-HSA-5654708 FRS-mediated FGFR4 signaling R-HSA-5654712 Downstream signaling of activated FGFR4 R-HSA-5654716 Negative regulation of FGFR1 signaling R-HSA-5654726 Negative regulation of FGFR2 signaling R-HSA-5654727 Negative regulation of FGFR3 signaling R-HSA-5654732 Negative regulation of FGFR4 signaling R-HSA-5654733 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 RHO GTPases Activate Formins R-HSA-5663220 RAF activation R-HSA-5673000 RAF/MAP kinase cascade R-HSA-5673001 MAP2K and MAPK activation R-HSA-5674135 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Platelet activation, signaling and aggregation R-HSA-76002 Platelet Aggregation (Plug Formation) R-HSA-76009 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 Interleukin receptor SHC signaling R-HSA-912526",IEA GO:0005634 nucleus IDA 16441665 cytoplasm GO:0005737 IDA 19767770 mitochondrion GO:0005739 IDA 12615910 mitochondrial inner membrane GO:0005743 IDA 20605918 lysosome GO:0005764 IDA 20605918 late endosome GO:0005770 IDA 19767770 cytosol GO:0005829 TAS GO:0005829 cytosol IEA GO:0005884 actin filament IDA 20605918 plasma membrane GO:0005886 TAS GO:0005886 plasma membrane IDA 17848177 caveola GO:0005901 IEA GO:0014069 postsynaptic density IBA GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA GO:0032587 ruffle membrane IEA GO:0043005 neuron projection IEA GO:0048471 perinuclear region of cytoplasm IDA 19056867 20458337 23376485 extracellular exosome GO:0070062,"GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS GO:0007049 cell cycle IEA 9020193 10734107 GO:0007165 signal transduction TAS 9924018 GO:0007172 signal complex assembly TAS GO:0007173 epidermal growth factor receptor signaling pathway IBA GO:0007173 epidermal growth factor receptor signaling pathway TAS 24036928 GO:0007179 transforming growth factor beta receptor signaling pathway IMP 24036928 GO:0007229 integrin-mediated signaling pathway IMP GO:0007417 central nervous system development IBA GO:0008283 cell proliferation IEA GO:0009612 response to mechanical stimulus IEA GO:0009615 response to virus IEA GO:0010447 response to acidic pH IEA 21724833 GO:0010632 regulation of epithelial cell migration IMP 18054784 GO:0010634 positive regulation of epithelial cell migration IMP GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway IEA GO:0010907 positive regulation of glucose metabolic process IEA GO:0014911 positive regulation of smooth muscle cell migration IEA GO:0016032 viral process IEA GO:0016337 single organismal cell-cell adhesion IEA GO:0018105 peptidyl-serine phosphorylation IEA 22732588 GO:0018108 peptidyl-tyrosine phosphorylation IDA 21724833 GO:0022407 regulation of cell-cell adhesion IMP GO:0030168 platelet activation TAS GO:0030520 intracellular estrogen receptor signaling pathway IBA GO:0030900 forebrain development IEA GO:0031295 T cell costimulation TAS GO:0031648 protein destabilization IEA GO:0031667 response to nutrient levels IEA GO:0031954 positive regulation of protein autophosphorylation IEA GO:0032148 activation of protein kinase B activity IEA 21531765 GO:0032211 negative regulation of telomere maintenance via telomerase IMP 19767770 GO:0032463 negative regulation of protein homooligomerization IMP GO:0032869 cellular response to insulin stimulus IEA GO:0033146 regulation of intracellular estrogen receptor signaling pathway IEA 19267251 GO:0033625 positive regulation of integrin activation TAS GO:0034332 adherens junction organization IEA GO:0034446 substrate adhesion-dependent cell spreading IEA GO:0034614 cellular response to reactive oxygen species IEA 15248232 GO:0035556 intracellular signal transduction IDA GO:0036035 osteoclast development IBA GO:0036120 cellular response to platelet-derived growth factor stimulus IEA GO:0038083 peptidyl-tyrosine autophosphorylation IBA GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS GO:0038128 ERBB2 signaling pathway TAS GO:0042127 regulation of cell proliferation IBA GO:0042493 response to drug IEA GO:0042542 response to hydrogen peroxide IEA GO:0043065 positive regulation of apoptotic process IEA 19767770 GO:0043066 negative regulation of apoptotic process IMP 19267251 GO:0043114 regulation of vascular permeability TAS 24036928 GO:0043149 stress fiber assembly IMP 19767770 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP GO:0043393 regulation of protein binding IEA GO:0043406 positive regulation of MAP kinase activity IEA GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA GO:0045056 transcytosis IEA GO:0045087 innate immune response IBA 19267251 GO:0045124 regulation of bone resorption TAS GO:0045453 bone resorption ISS GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA GO:0045892 negative regulation of transcription, DNA-templated IEA GO:0045893 positive regulation of transcription, DNA-templated IEA GO:0046628 positive regulation of insulin receptor signaling pathway IEA 16441665 GO:0046777 protein autophosphorylation IDA GO:0048008 platelet-derived growth factor receptor signaling pathway IBA GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS GO:0048011 neurotrophin TRK receptor signaling pathway IEA GO:0048013 ephrin receptor signaling pathway TAS GO:0048477 oogenesis IEA GO:0050715 positive regulation of cytokine secretion IEA 18054784 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IC GO:0050847 progesterone receptor signaling pathway IBA GO:0050847 progesterone receptor signaling pathway ISS GO:0050900 leukocyte migration TAS GO:0051385 response to mineralocorticoid IEA GO:0051602 response to electrical stimulus IEA GO:0051726 regulation of cell cycle IBA GO:0051895 negative regulation of focal adhesion assembly ISS 19767770 GO:0051897 positive regulation of protein kinase B signaling IMP 19767770 GO:0051902 negative regulation of mitochondrial depolarization IMP 21531765 GO:0051974 negative regulation of telomerase activity IMP GO:0060065 uterus development IEA GO:0060444 branching involved in mammary gland duct morphogenesis IEA GO:0060491 regulation of cell projection assembly IEA GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA 19281832 GO:0070555 response to interleukin-1 IMP GO:0071222 cellular response to lipopolysaccharide IEA GO:0071375 cellular response to peptide hormone stimulus ISS GO:0071393 cellular response to progesterone stimulus ISS GO:0071398 cellular response to fatty acid IEA GO:0071456 cellular response to hypoxia IEA GO:0071498 cellular response to fluid shear stress IEA GO:0071801 regulation of podosome assembly IBA GO:0071803 positive regulation of podosome assembly IEA 19059439 GO:0071902 positive regulation of protein serine/threonine kinase activity IDA GO:0086098 angiotensin-activated signaling pathway involved in heart process ISS GO:0090263 positive regulation of canonical Wnt signaling pathway IEA 18054784 GO:2000394 positive regulation of lamellipodium morphogenesis IMP GO:2000573 positive regulation of DNA biosynthetic process IEA 21724833 GO:2000641 regulation of early endosome to late endosome transport IMP 22402981 GO:2000811 negative regulation of anoikis IMP 19767770 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP 19767770 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway IMP 21724833 GO:2001286 regulation of caveolin-mediated endocytosis IMP",18616680 GO:0004672 protein kinase activity IDA GO:0004672 protein kinase activity TAS 1381360 9799234 10861086 11448999 12923167 15735019 16921024 17030621 18697750 GO:0004713 protein tyrosine kinase activity EXP 16441665 19059439 GO:0004713 protein tyrosine kinase activity IDA GO:0004713 protein tyrosine kinase activity TAS 19267251 GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS 9020193 GO:0005070 SH3/SH2 adaptor activity TAS GO:0005080 protein kinase C binding IEA 19332538 GO:0005102 receptor binding IPI GO:0005158 insulin receptor binding IEA 19267251 GO:0005178 integrin binding TAS 7478590 7537265 8070403 8681387 8849729 9148935 9162084 9600099 9763511 10521452 10542110 10698938 10801826 11007774 11149930 11741929 11923305 11940572 12857726 14963108 15143158 15546919 15735685 15749833 15866871 16115959 16169070 16273093 16291744 16374509 16479011 16511561 16537444 16636290 16741966 16899217 16964398 16966330 17038317 17092689 17094785 17141222 17170700 17178840 17284441 17318191 17412687 17474147 17491594 17525734 17936276 17974954 18070987 18155796 18273061 18328427 18377662 18464795 18662404 19262695 19372587 19419966 19661922 19732724 19903481 19910644 20100835 20158519 20624308 20935677 21034468 21075308 21278788 21685945 22402981 22439932 22581261 23065768 23397142 23564345 23954233 24034250 24658140 24728074 25117710 25241761 25814554 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0008022 protein C-terminus binding IEA GO:0016301 kinase activity TAS 21724833 GO:0019899 enzyme binding IPI 19059439 GO:0019900 kinase binding IPI 21036157 GO:0020037 heme binding IDA GO:0030331 estrogen receptor binding IEA 8070403 GO:0042169 SH2 domain binding IPI 8953041 12538589 GO:0044325 ion channel binding IPI 12925710 GO:0046875 ephrin receptor binding IPI 16441665 GO:0051219 phosphoprotein binding IPI GO:0051427 hormone receptor binding IBA 16479011 GO:0070851 growth factor receptor binding IPI 25006397 GO:0097110 scaffold protein binding IPI,hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04144 Endocytosis - Homo sapiens (human) hsa04370 VEGF signaling pathway - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04520 Adherens junction - Homo sapiens (human) hsa04530 Tight junction - Homo sapiens (human) hsa04540 Gap junction - Homo sapiens (human) hsa04611 Platelet activation - Homo sapiens (human) hsa04727 GABAergic synapse - Homo sapiens (human) hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04912 GnRH signaling pathway - Homo sapiens (human) hsa04915 Estrogen signaling pathway - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04921 Oxytocin signaling pathway - Homo sapiens (human) hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human) hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) hsa05131 Shigellosis - Homo sapiens (human) hsa05152 Tuberculosis - Homo sapiens (human) hsa05161 Hepatitis B - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05219 Bladder cancer - Homo sapiens (human),chemicalprobes.org P505-15,P43405,Tyrosine-protein kinase SYK,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,6850,KSYK,"R-HSA-109582 Hemostasis R-HSA-114604 GPVI-mediated activation cascade R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-139943 PLC-mediated hydrolysis of PIP2 R-HSA-162582 Signal Transduction R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029481 FCGR activation R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-2029485 Role of phospholipids in phagocytosis R-HSA-2172127 DAP12 interactions R-HSA-2424491 DAP12 signaling R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-2871809 FCERI mediated Ca+2 mobilization R-HSA-354192 Integrin alphaIIb beta3 signaling R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-5607764 CLEC7A (Dectin-1) signaling R-HSA-5621480 Dectin-2 family R-HSA-5621481 C-type lectin receptors (CLRs) R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-76009 Platelet Aggregation (Plug Formation) R-HSA-912631 Regulation of signaling by CBL R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983705 Signaling by the B Cell Receptor (BCR)",23071339 GO:0005634 nucleus IDA 23071339 GO:0005737 cytoplasm IDA 8163536 GO:0005829 cytosol IC GO:0005829 cytosol TAS GO:0005886 plasma membrane TAS GO:0019815 B cell receptor complex IEA GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA GO:0032009 early phagosome ISS 8176201 GO:0042101 T cell receptor complex IDA 23071339 GO:0043234 protein complex IDA,angiogenesis IEA GO:0001525 lymph vessel development ISS GO:0001945 positive regulation of receptor internalization IEA GO:0002092 stimulatory C-type lectin receptor signaling pathway TAS GO:0002223 adaptive immune response IBA GO:0002250 adaptive immune response ISS GO:0002250 macrophage activation involved in immune response IBA GO:0002281 macrophage activation involved in immune response ISS GO:0002281 neutrophil activation involved in immune response IBA GO:0002283 neutrophil activation involved in immune response ISS GO:0002283 leukocyte activation involved in immune response ISS GO:0002366 serotonin secretion by platelet ISS GO:0002554 protein phosphorylation IDA 17681949 GO:0006468 protein phosphorylation ISS GO:0006468 inflammatory response IBA GO:0006954 leukocyte cell-cell adhesion IDA 12885943 GO:0007159 transmembrane receptor protein tyrosine kinase signaling pathway IBA GO:0007169 integrin-mediated signaling pathway ISS GO:0007229 integrin-mediated signaling pathway NAS 12885943 GO:0007229 activation of JUN kinase activity IEA GO:0007257 cell proliferation TAS 10963601 GO:0008283 organ morphogenesis TAS 7477352 GO:0009887 regulation of platelet activation ISS GO:0010543 regulation of tumor necrosis factor-mediated signaling pathway IMP 19151749 GO:0010803 viral process IEA GO:0016032 peptidyl-serine phosphorylation IEA GO:0018105 leukotriene biosynthetic process IEA GO:0019370 platelet activation TAS GO:0030168 neutrophil chemotaxis IDA 12885943 GO:0030593 receptor internalization ISS GO:0031623 positive regulation of type I interferon production IEA GO:0032481 regulation of superoxide anion generation ISS GO:0032928 positive regulation of cell adhesion mediated by integrin IBA GO:0033630 positive regulation of cell adhesion mediated by integrin ISS GO:0033630 peptidyl-tyrosine autophosphorylation IBA GO:0038083 Fc-epsilon receptor signaling pathway TAS GO:0038095 Fc-gamma receptor signaling pathway involved in phagocytosis TAS GO:0038096 defense response to bacterium ISS GO:0042742 transcription factor import into nucleus IMP 23071339 GO:0042991 positive regulation of mast cell degranulation IBA GO:0043306 regulation of neutrophil degranulation ISS GO:0043313 beta selection IEA GO:0043366 innate immune response IBA GO:0045087 innate immune response ISS GO:0045087 positive regulation of interleukin-3 biosynthetic process IEA GO:0045401 positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process IEA GO:0045425 positive regulation of B cell differentiation IMP 18369315 GO:0045579 positive regulation of gamma-delta T cell differentiation IEA GO:0045588 positive regulation of bone resorption ISS GO:0045780 positive regulation of alpha-beta T cell differentiation IEA GO:0046638 positive regulation of alpha-beta T cell proliferation IBA GO:0046641 blood vessel morphogenesis ISS GO:0048514 positive regulation of cytokine secretion IEA GO:0050715 positive regulation of peptidyl-tyrosine phosphorylation IEA GO:0050731 regulation of phagocytosis ISS GO:0050764 positive regulation of calcium-mediated signaling IEA GO:0050850 B cell receptor signaling pathway IBA GO:0050853 B cell receptor signaling pathway ISS GO:0050853 regulation of sequence-specific DNA binding transcription factor activity IMP 23071339 GO:0051090 regulation of ERK1 and ERK2 cascade ISS GO:0070372 cellular response to molecule of fungal origin ISS GO:0071226 cellular response to low-density lipoprotein particle stimulus ISS GO:0071404 regulation of arachidonic acid secretion ISS GO:0090237 regulation of platelet aggregation IBA GO:0090330 regulation of platelet aggregation ISS GO:0090330,GO:0004672 protein kinase activity 18818202 IDA GO:0004672 protein kinase activity 12885943 NAS GO:0004674 protein serine/threonine kinase activity 23071339 IDA GO:0004713 protein tyrosine kinase activity 8629002 8657103 10648173 17993265 18818202 22041900 EXP GO:0004713 protein tyrosine kinase activity TAS GO:0004715 non-membrane spanning protein tyrosine kinase activity 8163536 IDA GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS GO:0004716 receptor signaling protein tyrosine kinase activity IEA GO:0005178 integrin binding 12885943 IPI GO:0005515 protein binding 7761456 8627166 8647200 8657103 8798676 8810294 9280292 9698567 11940607 15536084 16273093 18273061 20585042 20713593 21044950 21516116 22019427 22624718 23001182 23299888 24525236 24728074 25416956 25814554 IPI GO:0005524 ATP binding IEA GO:0019901 protein kinase binding IEA,NF-kappa B signaling pathway - Homo sapiens (human) hsa04064 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Osteoclast differentiation - Homo sapiens (human) hsa04380 Platelet activation - Homo sapiens (human) hsa04611 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04650 B cell receptor signaling pathway - Homo sapiens (human) hsa04662 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04664 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04666 Tuberculosis - Homo sapiens (human) hsa05152 Epstein-Barr virus infection - Homo sapiens (human) hsa05169 Viral carcinogenesis - Homo sapiens (human) hsa05203,chemicalprobes.org ABPA3,P22314,Ubiquitin-like modifier-activating enzyme 1,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,7317,UBA1,Adaptive Immune System R-HSA-1280218 Immune System R-HSA-168256 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983168 Class I MHC mediated antigen processing & presentation R-HSA-983169,GO:0000792 heterochromatin colocalizes_with 1376922 IDA GO:0005634 nucleus 1376922 21630459 22456334 IDA GO:0005737 cytoplasm 1376922 IDA GO:0005739 mitochondrion 1376922 IDA GO:0005765 lysosomal membrane colocalizes_with 1376922 IDA GO:0005829 cytosol IBA GO:0010008 endosome membrane colocalizes_with 1376922 IDA GO:0030057 desmosome colocalizes_with 1376922 IDA GO:0030867 rough endoplasmic reticulum membrane colocalizes_with 1376922 IDA GO:0070062 extracellular exosome 19056867 19199708 20458337 23376485 23533145 IDA,cellular response to DNA damage stimulus 22456334 GO:0006974 IDA protein ubiquitination GO:0016567 IEA modification-dependent protein catabolic process GO:0019941 IBA,ubiquitin activating enzyme activity 12629039 21685362 GO:0004839 IDA ubiquitin-protein transferase activity GO:0004842 IBA protein binding 16227972 17956732 22190034 GO:0005515 IPI ATP binding GO:0005524 IEA poly(A) RNA binding 22658674 22681889 GO:0044822 IDA,"hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human) hsa05012 Parkinson,s disease - Homo sapiens (human)",chemicalprobes.org OICR-9429,P61964,WD repeat-containing protein 5,0.0,NA,NA,NA,NA,NA,NA,NA,NULL,11091,WDR5,R-HSA-3214841 PKMTs methylate histone lysines R-HSA-3214847 HATs acetylate histones R-HSA-3214858 RMTs methylate histone arginines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization,histone acetyltransferase complex 20018852 GO:0000123 IDA nucleus 17500065 GO:0005634 IDA nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS Ada2/Gcn5/Ada3 transcription activator complex 18838386 GO:0005671 IDA histone methyltransferase complex 17355966 17500065 19556245 GO:0035097 IDA MLL3/4 complex 17500065 GO:0044666 IDA Set1C/COMPASS complex 17998332 18838538 GO:0048188 IDA MLL1 complex 15960975 GO:0071339 IDA,"skeletal system development IEA GO:0001501 transcription, DNA-templated IEA GO:0006351 neuron projection development IEA GO:0031175 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IEA GO:0035948 histone H3 acetylation IDA 18838386 GO:0043966 histone H4-K5 acetylation IDA 20018852 GO:0043981 histone H4-K8 acetylation IDA 20018852 GO:0043982 histone H4-K16 acetylation IDA 20018852 GO:0043984 histone H3-K4 methylation IDA 17355966 19556245 GO:0051568",protein binding GO:0005515 IPI 12670868 15960975 16946699 17021013 17041588 17178841 17500065 17925232 17998332 18378692 18840606 19556245 20085832 20581860 21044950 23555304 23870121 24788516 25416956 histone-lysine N-methyltransferase activity GO:0018024 TAS methylated histone binding GO:0035064 IDA 16600877 histone methyltransferase activity (H3-K4 specific) GO:0042800 contributes_to IDA 17355966 histone acetyltransferase activity (H4-K5 specific) GO:0043995 contributes_to IDA 20018852 histone acetyltransferase activity (H4-K8 specific) GO:0043996 contributes_to IDA 20018852 histone acetyltransferase activity (H4-K16 specific) GO:0046972 contributes_to IDA 20018852,,chemicalprobes.org CHEMBL2153191,P28845,11-beta-hydroxysteroid dehydrogenase 1,1.0,ORTHOGONAL,NO,CCCSc1nc(ccc1C(=O)NC2CCCCC2)N3CCC[C@@H](CC(=O)O)C3,4,15,"InChI=1S/C22H33N3O3S/c1-2-13-29-22-18(21(28)23-17-8-4-3-5-9-17)10-11-19(24-22)25-12-6-7-16(15-25)14-20(26)27/h10-11,16-17H,2-9,12-15H2,1H3,(H,23,28)(H,26,27)/t16-/m0/s1",NCDZABJPWMBMIQ-INIZCTEOSA-N,"c(""11-beta-hydroxysteroid dehydrogenase 1"", ""11-beta-hydroxysteroid dehydrogenase 2"", ""Estradiol 17-beta-dehydrogenase 1"", ""Estradiol 17-beta-dehydrogenase 3"", ""Unchecked"")",3290,DHI1,Metabolism R-HSA-1430728 Glucocorticoid biosynthesis R-HSA-194002 Metabolism of steroid hormones and vitamin D R-HSA-196071 Steroid hormones R-HSA-209943 Metabolism of lipids and lipoproteins R-HSA-556833,endoplasmic reticulum membrane GO:0005789 TAS membrane 19946888 GO:0016020 IDA integral component of membrane GO:0016021 IEA,TAS GO:0006704 glucocorticoid biosynthetic process IEA GO:0030324 lung development IEA GO:0055114 oxidation-reduction process,TAS GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity IEA GO:0070524 11-beta-hydroxysteroid dehydrogenase (NADP+) activity,Steroid hormone biosynthesis - Homo sapiens (human) hsa00140 Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) hsa00980 Chemical carcinogenesis - Homo sapiens (human) hsa05204,CHEMBL CHEMBL1829763,P28845,11-beta-hydroxysteroid dehydrogenase 1,1.0,PRIMARY,NO,C[C@H](N1CC[C@@](CCO)(OC1=O)c2ccc(F)cc2)c3ccc(cc3)c4ccc(F)cc4F,7,22,"InChI=1S/C26H24F3NO3/c1-17(18-2-4-19(5-3-18)23-11-10-22(28)16-24(23)29)30-14-12-26(13-15-31,33-25(30)32)20-6-8-21(27)9-7-20/h2-11,16-17,31H,12-15H2,1H3/t17-,26-/m0/s1",SLSMHOGJKAPYQU-QLXKLKPCSA-N,"c(""Mineralocorticoid receptor"", ""Glucocorticoid receptor"", ""Bile acid receptor FXR"", ""3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type II"", ""Estradiol 17-beta-dehydrogenase 1"", ""11-beta-hydroxysteroid dehydrogenase 2"", ""11-beta-hydroxysteroid dehydrogenase 1"", ""Unchecked"")",3290,DHI1,Metabolism R-HSA-1430728 Glucocorticoid biosynthesis R-HSA-194002 Metabolism of steroid hormones and vitamin D R-HSA-196071 Steroid hormones R-HSA-209943 Metabolism of lipids and lipoproteins R-HSA-556833,endoplasmic reticulum membrane GO:0005789 TAS membrane 19946888 GO:0016020 IDA integral component of membrane GO:0016021 IEA,TAS GO:0006704 glucocorticoid biosynthetic process IEA GO:0030324 lung development IEA GO:0055114 oxidation-reduction process,TAS GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity IEA GO:0070524 11-beta-hydroxysteroid dehydrogenase (NADP+) activity,Steroid hormone biosynthesis - Homo sapiens (human) hsa00140 Metabolism of xenobiotics by cytochrome P450 - Homo sapiens (human) hsa00980 Chemical carcinogenesis - Homo sapiens (human) hsa05204,CHEMBL CHEMBL1689279,P80365,11-beta-hydroxysteroid dehydrogenase 2,1.0,ORTHOGONAL,NO,C[C@@]1(CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CCC(=O)NC(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1)NC(=O)N,2,5,"InChI=1S/C30H47N3O3/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(35)32-25)20(34)16-18-19-17-27(4,33-24(31)36)14-12-26(19,3)13-15-29(18,30)6/h16,19,21,23H,8-15,17H2,1-7H3,(H,32,35)(H3,31,33,36)/t19-,21-,23+,26+,27-,28-,29+,30+/m0/s1",OXEJYJIHFPSCHI-LPXJIFNVSA-N,"c(""11-beta-hydroxysteroid dehydrogenase 1"", ""11-beta-hydroxysteroid dehydrogenase 2"", ""Unchecked"")",3291,DHI2,R-HSA-1430728 Metabolism R-HSA-194002 Glucocorticoid biosynthesis R-HSA-196071 Metabolism of steroid hormones and vitamin D R-HSA-209943 Steroid hormones R-HSA-556833 Metabolism of lipids and lipoproteins,GO:0005789 endoplasmic reticulum membrane TAS,IEA GO:0001666 response to hypoxia IEA GO:0002017 regulation of blood volume by renal aldosterone TAS GO:0006704 glucocorticoid biosynthetic process IEA GO:0007565 female pregnancy IEA GO:0032094 response to food IEA GO:0032868 response to insulin IEA GO:0042493 response to drug IEA GO:0051384 response to glucocorticoid IEA GO:0055114 oxidation-reduction process,TAS GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity IEA GO:0005496 steroid binding IEA GO:0051287 NAD binding,Steroid hormone biosynthesis - Homo sapiens (human) hsa00140 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) hsa04960,CHEMBL CHEMBL1269273,P80365,11-beta-hydroxysteroid dehydrogenase 2,1.0,PRIMARY,NO,CN(O)C(=O)[C@@]1(C)CC[C@]2(C)CC[C@]3(C)C(=CC(=O)[C@@H]4[C@@]5(C)CC[C@H](OC(=O)C)C(C)(C)[C@@H]5CC[C@@]34C)[C@@H]2C1,2,12,"InChI=1S/C33H51NO5/c1-20(35)39-25-11-12-31(6)24(28(25,2)3)10-13-33(8)26(31)23(36)18-21-22-19-30(5,27(37)34(9)38)15-14-29(22,4)16-17-32(21,33)7/h18,22,24-26,38H,10-17,19H2,1-9H3/t22-,24-,25-,26+,29+,30-,31-,32+,33+/m0/s1",JMPAVZYYYUPQJB-IREBYWSLSA-N,"c(""11-beta-hydroxysteroid dehydrogenase 1"", ""11-beta-hydroxysteroid dehydrogenase 2"", ""Unchecked"")",3291,DHI2,R-HSA-1430728 Metabolism R-HSA-194002 Glucocorticoid biosynthesis R-HSA-196071 Metabolism of steroid hormones and vitamin D R-HSA-209943 Steroid hormones R-HSA-556833 Metabolism of lipids and lipoproteins,GO:0005789 endoplasmic reticulum membrane TAS,IEA GO:0001666 response to hypoxia IEA GO:0002017 regulation of blood volume by renal aldosterone TAS GO:0006704 glucocorticoid biosynthetic process IEA GO:0007565 female pregnancy IEA GO:0032094 response to food IEA GO:0032868 response to insulin IEA GO:0042493 response to drug IEA GO:0051384 response to glucocorticoid IEA GO:0055114 oxidation-reduction process,TAS GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity IEA GO:0005496 steroid binding IEA GO:0051287 NAD binding,Steroid hormone biosynthesis - Homo sapiens (human) hsa00140 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) hsa04960,CHEMBL CHEMBL1922660,P20292,5-lipoxygenase activating protein,1.0,PRIMARY,NO,CCOc1ccc(cn1)c2ccc(Cn3c(CC(C)(C)C(=O)O)c(SC(C)(C)C)c4cc(OCc5ccc(C)cn5)ccc34)cc2,6,14,"InChI=1S/C38H43N3O4S/c1-8-44-34-18-14-28(22-40-34)27-12-10-26(11-13-27)23-41-32-17-16-30(45-24-29-15-9-25(2)21-39-29)19-31(32)35(46-37(3,4)5)33(41)20-38(6,7)36(42)43/h9-19,21-22H,8,20,23-24H2,1-7H3,(H,42,43)",DFQGDHBGRSTTHX-UHFFFAOYSA-N,"c(""5-lipoxygenase activating protein"", ""Cyclooxygenase-1"", ""Leukotriene A4 hydrolase"", ""Leukotriene C4 synthase"", ""Arachidonate 5-lipoxygenase"", ""Cyclooxygenase-2"")",241,AL5AP,R-HSA-1430728 Metabolism R-HSA-2142688 Synthesis of 5-eicosatetraenoic acids R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142700 Synthesis of Lipoxins (LX) R-HSA-2142753 Arachidonic acid metabolism R-HSA-556833 Metabolism of lipids and lipoproteins,nuclear envelope IDA 19233132 GO:0005635 nuclear envelope TAS GO:0005635 endoplasmic reticulum IDA 19233132 GO:0005783 endoplasmic reticulum membrane IEA GO:0005789 membrane IDA 19946888 GO:0016020 integral component of membrane IEA GO:0016021 nuclear membrane IDA 8245774 GO:0031965,leukotriene metabolic process GO:0006691 TAS leukotriene biosynthetic process GO:0019370 2300173 IDA lipoxygenase pathway GO:0019372 TAS positive regulation of catalytic activity GO:0043085 IEA protein homotrimerization GO:0070207 17600184 IPI cellular response to calcium ion GO:0071277 2300173 IDA lipoxin metabolic process GO:2001300 TAS,glutathione transferase activity GO:0004364 IBA NOT leukotriene-C4 synthase activity GO:0004464 IBA NOT glutathione peroxidase activity GO:0004602 IBA NOT protein binding GO:0005515 19233132 IPI enzyme activator activity GO:0008047 IEA protein N-terminus binding GO:0047485 19233132 IPI arachidonic acid binding GO:0050544 8440384 IDA,,CHEMBL CHEMBL407874,P16455,6-O-methylguanine-DNA methyltransferase,1.0,PRIMARY,NO,Nc1nc(OCc2ccccc2)c3nc[nH]c3n1,2,104,"InChI=1S/C12H11N5O/c13-12-16-10-9(14-7-15-10)11(17-12)18-6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H3,13,14,15,16,17)",KRWMERLEINMZFT-UHFFFAOYSA-N,"c(""6-O-methylguanine-DNA methyltransferase"", ""Cyclin-dependent kinase 1/cyclin B1"", ""Cyclin-dependent kinase 2/cyclin A"", ""HeLa"", ""HT-29"", ""M4Beu cell line"", ""Unchecked"", ""Prelamin-A/C"", ""Nuclear factor NF-kappa-B p105 subunit"", ""Thyroid stimulating hormone receptor"", ""Peripheral myelin protein 22"", ""Bloom syndrome protein"", ""Mitogen-activated protein kinase kinase kinase 5"", ""ATPase family AAA domain-containing protein 5"", ""Histone-lysine N-methyltransferase, H3 lysine-9 specific 3"", ""Chromobox protein homolog 1"", ""HEK293"", ""SH-SY5Y"", ""SN12C"", ""ACHN"", ""NCI-H23"", ""UO-31"", ""HL-60"", ""HOP-92"", ""SF-539"", ""SK-MEL-5"", ""Malme-3M"", ""K562"", ""A498"", ""OVCAR-3"", ""MOLT-4"", ""HOP-62"", ""OVCAR-8"", ""U-251"", ""OVCAR-5"", ""SNB-19"", ""DMS-273"", ""TK-10"", ""M19-MEL"", ""SW-620"", ""NCI-H522"", ""KM12"", ""M14"", ""NCI-H322M"", ""OVCAR-4"", ""LOX IMVI"", ""SK-MEL-2"", ""KM-20L2"", ""HCC 2998"", ""A549"", ""SNB-75"", ""HCT-116"", ""HCT-15"", ""EKVX"", ""SF-268"", ""LXFL 529"", ""DMS-114"", ""SK-OV-3"", ""NCI-H460"", ""UACC-62"", ""CAKI-1"", ""SF-295"", ""IGROV-1"", ""RXF 631"", ""786-0"", ""SNB-78"", ""UACC-257"", ""CCRF-CEM"", ""DLD-1"", ""NCI-H226"", ""SK-MEL-28"", ""COLO 205"", ""RXF 393"", ""HOP-18"", ""Geminin"", ""Transcriptional regulator ERG"", ""Cerebroside-sulfatase"")",4255,MGMT,MGMT-mediated DNA damage reversal R-HSA-5657655 DNA Repair R-HSA-73894 DNA Damage Reversal R-HSA-73942,GO:0005634 nucleus 2188979 TAS GO:0005654 nucleoplasm IDA GO:0005654 nucleoplasm TAS GO:0016020 membrane 19946888 IDA,DNA ligation 2188979 GO:0006266 TAS DNA methylation GO:0006306 IEA DNA dealkylation involved in DNA repair GO:0006307 IBA DNA dealkylation involved in DNA repair GO:0006307 TAS response to toxic substance GO:0009636 IEA cellular response to oxidative stress GO:0034599 IEA response to drug GO:0042493 IEA negative regulation of apoptotic process 24147153 GO:0043066 IDA regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 IEA response to ethanol GO:0045471 IEA response to folic acid GO:0051593 IEA mammary gland epithelial cell differentiation GO:0060644 IEA cellular response to organic cyclic compound GO:0071407 IEA cellular response to ionizing radiation GO:0071479 IEA positive regulation of double-strand break repair 24147153 GO:2000781 IDA,DNA binding 2188979 GO:0003677 TAS damaged DNA binding GO:0003684 IBA methylated-DNA-[protein]-cysteine S-methyltransferase activity GO:0003908 IBA calcium ion binding GO:0005509 IEA methyltransferase activity 2188979 GO:0008168 TAS DNA-methyltransferase activity 2405387 GO:0009008 TAS,,CHEMBL CHEMBL3421731,Q16875,"6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3",1.0,PRIMARY,NO,Cn1cc(cn1)c2cn(C)c3ccc(Oc4ccc(NC(=O)[C@@H]5CCCN5)cc4)cc23,3,7,"InChI=1S/C24H25N5O2/c1-28-15-21(16-13-26-29(2)14-16)20-12-19(9-10-23(20)28)31-18-7-5-17(6-8-18)27-24(30)22-4-3-11-25-22/h5-10,12-15,22,25H,3-4,11H2,1-2H3,(H,27,30)/t22-/m0/s1",JTIOFEOXCFFWJI-QFIPXVFZSA-N,"c(""6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1"", ""6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2"", ""6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3"")",5209,F263,R-HSA-1430728 Metabolism R-HSA-70171 Glycolysis R-HSA-70326 Glucose metabolism R-HSA-71387 Metabolism of carbohydrates,nucleoplasm GO:0005654 IDA cytosol GO:0005829 TAS,"GO:0006000 fructose metabolic process IEA GO:0006003 fructose 2,6-bisphosphate metabolic process IEA GO:0007420 brain development IEA GO:0016311 dephosphorylation IEA GO:0046835 carbohydrate phosphorylation IEA GO:0061621 canonical glycolysis TAS","2837207 9464277 10095107 15896703 GO:0003873 6-phosphofructo-2-kinase activity EXP 8830046 GO:0003873 6-phosphofructo-2-kinase activity NAS GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity IEA GO:0005524 ATP binding IEA",hsa00051 Fructose and mannose metabolism - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04152 AMPK signaling pathway - Homo sapiens (human),CHEMBL CHEMBL3215768,P22303,Acetylcholinesterase,1.0,ORTHOGONAL,NO,Cl.Cl.Cl.Cl.Clc1ccc(cc1)c2nc3ccc(cc3c4OCCCc24)C(=O)NCCCCCCCCNc5c6CCCCc6nc7cc(Cl)ccc57,4,7,"InChI=1S/C40H42Cl2N4O2.4ClH/c41-28-16-13-26(14-17-28)37-32-11-9-23-48-39(32)33-24-27(15-20-35(33)46-37)40(47)44-22-8-4-2-1-3-7-21-43-38-30-10-5-6-12-34(30)45-36-25-29(42)18-19-31(36)38;;;;/h13-20,24-25H,1-12,21-23H2,(H,43,45)(H,44,47);4*1H",MXLJUEZGDWPRHU-UHFFFAOYSA-N,"c(""Acetylcholinesterase"", ""Butyrylcholinesterase"", ""Unchecked"", ""Beta amyloid A4 protein"", ""Beta-secretase 1"")",43,ACES,Neurotransmitter Clearance In The Synaptic Cleft R-HSA-112311 Transmission across Chemical Synapses R-HSA-112315 Neuronal System R-HSA-112316 Metabolism R-HSA-1430728 Synthesis of PC R-HSA-1483191 Glycerophospholipid biosynthesis R-HSA-1483206 Phospholipid metabolism R-HSA-1483257 Metabolism of lipids and lipoproteins R-HSA-556833,IDA 1517212 extracellular region GO:0005576 TAS 11283752 extracellular region GO:0005576 NAS 16289501 basal lamina GO:0005605 IBA GO:0005615 extracellular space IEA GO:0005634 nucleus IDA 15454088 Golgi apparatus GO:0005794 TAS GO:0005886 plasma membrane IEA GO:0009986 cell surface IDA 16262697 membrane GO:0016020 IEA GO:0030054 cell junction IEA GO:0031225 anchored component of membrane IBA GO:0031594 neuromuscular junction IEA GO:0043083 synaptic cleft IDA 8460160 synapse GO:0045202 IDA 14766237 perinuclear region of cytoplasm GO:0048471,"acetylcholine catabolic process in synaptic cleft NAS 1517212 GO:0001507 regulation of receptor recycling IEA GO:0001919 osteoblast development IEP 15454088 GO:0002076 DNA replication TAS 11283752 GO:0006260 acetylcholine catabolic process IDA 1517212 GO:0006581 phosphatidylcholine biosynthetic process TAS GO:0006656 cell adhesion IDA 15454088 GO:0007155 cell adhesion TAS 11283752 GO:0007155 nervous system development TAS 11283752 GO:0007399 synapse assembly TAS 11283752 GO:0007416 muscle organ development TAS 11283752 GO:0007517 cell proliferation TAS 11283752 GO:0008283 response to wounding TAS 11283752 GO:0009611 receptor internalization IEA GO:0031623 negative regulation of synaptic transmission, cholinergic IC 1517212 GO:0032223 neurotransmitter biosynthetic process TAS GO:0042136 amyloid precursor protein metabolic process TAS 12769797 GO:0042982 neurotransmitter receptor biosynthetic process IEA GO:0045212 positive regulation of protein secretion TAS 11283752 GO:0050714 protein tetramerization IEA GO:0051262 retina development in camera-type eye IEA GO:0060041",beta-amyloid binding TAS 11283752 GO:0001540 acetylcholinesterase activity IDA 1517212 GO:0003990 acetylcholinesterase activity IMP 1517212 GO:0003990 acetylcholinesterase activity TAS GO:0003990 cholinesterase activity IDA 1517212 GO:0004104 protein binding IPI 10800960 15526038 18194455 GO:0005515 collagen binding IDA 12524166 GO:0005518 hydrolase activity IDA 1517212 GO:0016787 serine hydrolase activity IDA 3954986 GO:0017171 acetylcholine binding IDA 8349597 GO:0042166 acetylcholine binding NAS 1517212 GO:0042166 protein homodimerization activity IPI 12524166 GO:0042803 protein homodimerization activity NAS 1517212 GO:0042803 laminin binding IDA 12524166 GO:0043236 protein self-association IEA GO:0043621,Glycerophospholipid metabolism - Homo sapiens (human) hsa00564 Cholinergic synapse - Homo sapiens (human) hsa04725,CHEMBL CHEMBL54126,P22303,Acetylcholinesterase,1.0,PRIMARY,NO,[Br-].CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C,5,37,"InChI=1S/C12H19N2O2.BrH/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H/q+1;/p-1",LULNWZDBKTWDGK-UHFFFAOYSA-M,"c(""Acetylcholinesterase"", ""Solute carrier family 22 member 1"", ""Butyrylcholinesterase"", ""Menin/Histone-lysine N-methyltransferase MLL"", ""Prelamin-A/C"", ""Neuropeptide S receptor"", ""Unchecked"", ""Chromobox protein homolog 1"", ""P-glycoprotein 1"", ""Muscleblind-like protein 1"", ""DNA-(apurinic or apyrimidinic site) lyase"")",43,ACES,Neurotransmitter Clearance In The Synaptic Cleft R-HSA-112311 Transmission across Chemical Synapses R-HSA-112315 Neuronal System R-HSA-112316 Metabolism R-HSA-1430728 Synthesis of PC R-HSA-1483191 Glycerophospholipid biosynthesis R-HSA-1483206 Phospholipid metabolism R-HSA-1483257 Metabolism of lipids and lipoproteins R-HSA-556833,IDA 1517212 extracellular region GO:0005576 TAS 11283752 extracellular region GO:0005576 NAS 16289501 basal lamina GO:0005605 IBA GO:0005615 extracellular space IEA GO:0005634 nucleus IDA 15454088 Golgi apparatus GO:0005794 TAS GO:0005886 plasma membrane IEA GO:0009986 cell surface IDA 16262697 membrane GO:0016020 IEA GO:0030054 cell junction IEA GO:0031225 anchored component of membrane IBA GO:0031594 neuromuscular junction IEA GO:0043083 synaptic cleft IDA 8460160 synapse GO:0045202 IDA 14766237 perinuclear region of cytoplasm GO:0048471,"acetylcholine catabolic process in synaptic cleft NAS 1517212 GO:0001507 regulation of receptor recycling IEA GO:0001919 osteoblast development IEP 15454088 GO:0002076 DNA replication TAS 11283752 GO:0006260 acetylcholine catabolic process IDA 1517212 GO:0006581 phosphatidylcholine biosynthetic process TAS GO:0006656 cell adhesion IDA 15454088 GO:0007155 cell adhesion TAS 11283752 GO:0007155 nervous system development TAS 11283752 GO:0007399 synapse assembly TAS 11283752 GO:0007416 muscle organ development TAS 11283752 GO:0007517 cell proliferation TAS 11283752 GO:0008283 response to wounding TAS 11283752 GO:0009611 receptor internalization IEA GO:0031623 negative regulation of synaptic transmission, cholinergic IC 1517212 GO:0032223 neurotransmitter biosynthetic process TAS GO:0042136 amyloid precursor protein metabolic process TAS 12769797 GO:0042982 neurotransmitter receptor biosynthetic process IEA GO:0045212 positive regulation of protein secretion TAS 11283752 GO:0050714 protein tetramerization IEA GO:0051262 retina development in camera-type eye IEA GO:0060041",beta-amyloid binding TAS 11283752 GO:0001540 acetylcholinesterase activity IDA 1517212 GO:0003990 acetylcholinesterase activity IMP 1517212 GO:0003990 acetylcholinesterase activity TAS GO:0003990 cholinesterase activity IDA 1517212 GO:0004104 protein binding IPI 10800960 15526038 18194455 GO:0005515 collagen binding IDA 12524166 GO:0005518 hydrolase activity IDA 1517212 GO:0016787 serine hydrolase activity IDA 3954986 GO:0017171 acetylcholine binding IDA 8349597 GO:0042166 acetylcholine binding NAS 1517212 GO:0042166 protein homodimerization activity IPI 12524166 GO:0042803 protein homodimerization activity NAS 1517212 GO:0042803 laminin binding IDA 12524166 GO:0043236 protein self-association IEA GO:0043621,Glycerophospholipid metabolism - Homo sapiens (human) hsa00564 Cholinergic synapse - Homo sapiens (human) hsa04725,CHEMBL CHEMBL3110081,O00763,Acetyl-CoA carboxylase 2,1.0,PRIMARY,NO,CCOc1ccc(N2CCN([C@@H](C)C2)c3noc(CC)n3)c(C)c1,2,4,"InChI=1S/C18H26N4O2/c1-5-17-19-18(20-24-17)22-10-9-21(12-14(22)4)16-8-7-15(23-6-2)11-13(16)3/h7-8,11,14H,5-6,9-10,12H2,1-4H3/t14-/m0/s1",IDCAZOYSDXUCSQ-AWEZNQCLSA-N,"c(""Unchecked"", ""Acetyl-CoA carboxylase 2"", ""Acetyl-CoA carboxylase 1"")",32,ACACB,"Metabolism R-HSA-1430728 Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-1655829 Biotin transport and metabolism R-HSA-196780 Metabolism of water-soluble vitamins and cofactors R-HSA-196849 Metabolism of vitamins and cofactors R-HSA-196854 Import of palmitoyl-CoA into the mitochondrial matrix R-HSA-200425 Activation of gene expression by SREBF (SREBP) R-HSA-2426168 Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-535734 Metabolism of lipids and lipoproteins R-HSA-556833",10677481 IDA GO:0005634 nucleus 10677481 IDA GO:0005739 mitochondrion TAS GO:0005741 mitochondrial outer membrane TAS GO:0005829 cytosol IEA GO:0012505 endomembrane system,GO:0006084 acetyl-CoA metabolic process 20952656 IDA GO:0006633 fatty acid biosynthetic process IEA GO:0006768 biotin metabolic process TAS GO:0006853 carnitine shuttle TAS GO:0010629 negative regulation of gene expression IEA GO:0010884 positive regulation of lipid storage IEA GO:0010906 regulation of glucose metabolic process IEA GO:0031325 positive regulation of cellular metabolic process TAS GO:0031667 response to nutrient levels IEA GO:0031999 negative regulation of fatty acid beta-oxidation IEA GO:0043086 negative regulation of catalytic activity IEA GO:0051289 protein homotetramerization 20952656 IDA GO:0060421 positive regulation of heart growth IEA GO:0097009 energy homeostasis IEA GO:2001295 malonyl-CoA biosynthetic process IEA,GO:0003989 acetyl-CoA carboxylase activity 20952656 IDA GO:0004075 biotin carboxylase activity IEA GO:0005515 protein binding 16794074 20085763 20952656 IPI GO:0005524 ATP binding IEA GO:0046872 metal ion binding IEA,hsa00061 Fatty acid biosynthesis - Homo sapiens (human) hsa00620 Pyruvate metabolism - Homo sapiens (human) hsa00640 Propanoate metabolism - Homo sapiens (human) hsa04152 AMPK signaling pathway - Homo sapiens (human) hsa04910 Insulin signaling pathway - Homo sapiens (human) hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) hsa04922 Glucagon signaling pathway - Homo sapiens (human),CHEMBL CHEMBL1087014,O00767,Acyl-CoA desaturase,1.0,PRIMARY,NO,Cc1onc(n1)c2cnc(s2)N3CCC(CC3)Oc4ccccc4C(F)(F)F,3,3,"InChI=1S/C18H17F3N4O2S/c1-11-23-16(24-27-11)15-10-22-17(28-15)25-8-6-12(7-9-25)26-14-5-3-2-4-13(14)18(19,20)21/h2-5,10,12H,6-9H2,1H3",OYUCOYCEJWDVQK-UHFFFAOYSA-N,"c(""Acyl-CoA desaturase"", ""Fatty acid desaturase 1"", ""Fatty acid desaturase 2"")",6319,ACOD,,endoplasmic reticulum GO:0005783 IDA endoplasmic reticulum membrane GO:0005789 15907797 IDA endoplasmic reticulum membrane GO:0005789 TAS membrane GO:0016020 19946888 IDA integral component of membrane GO:0016021 18765284 IDA,unsaturated fatty acid biosynthetic process GO:0006636 IDA 15907797 18765284 long-chain fatty-acyl-CoA biosynthetic process GO:0035338 TAS oxidation-reduction process GO:0055114 IEA,stearoyl-CoA 9-desaturase activity GO:0004768 IDA 15907797 18765284 stearoyl-CoA 9-desaturase activity GO:0004768 TAS iron ion binding GO:0005506 IDA 18765284 oxidoreductase activity GO:0016491 IDA 15907797 18765284,Biosynthesis of unsaturated fatty acids - Homo sapiens (human) hsa01040 PPAR signaling pathway - Homo sapiens (human) hsa03320 AMPK signaling pathway - Homo sapiens (human) hsa04152,CHEMBL CHEMBL222752,P23141,Acyl coenzyme A:cholesterol acyltransferase,1.0,ORTHOGONAL,NO,O=C1N(Cc2ccc(Cc3ccc(CN4C(=O)C(=O)c5ccccc45)cc3)cc2)c6ccccc6C1=O,3,5,"InChI=1S/C31H22N2O4/c34-28-24-5-1-3-7-26(24)32(30(28)36)18-22-13-9-20(10-14-22)17-21-11-15-23(16-12-21)19-33-27-8-4-2-6-25(27)29(35)31(33)37/h1-16H,17-19H2",OGTUYARYUMRJAT-UHFFFAOYSA-N,"c(""Butyrylcholinesterase"", ""Acyl coenzyme A:cholesterol acyltransferase"", ""Unchecked"", ""Acetylcholinesterase"")",1066,EST1,,extracellular space GO:0005615 IBA endoplasmic reticulum lumen GO:0005788 TAS,TAS GO:0006805 xenobiotic metabolic process TAS 1918003 metabolic process GO:0008152 TAS 1918003 response to toxic substance GO:0009636 IDA 21492153 epithelial cell differentiation GO:0030855,IEA GO:0047374 methylumbelliferyl-acetate deacetylase activity TAS GO:0052689 carboxylic ester hydrolase activity,Drug metabolism - other enzymes - Homo sapiens (human) hsa00983,CHEMBL CHEMBL222644,P23141,Acyl coenzyme A:cholesterol acyltransferase,1.0,PRIMARY,NO,CCCCCCCCCCCCN1C(=O)C(=O)c2ccccc12,4,6,"InChI=1S/C20H29NO2/c1-2-3-4-5-6-7-8-9-10-13-16-21-18-15-12-11-14-17(18)19(22)20(21)23/h11-12,14-15H,2-10,13,16H2,1H3",GQEQKTGRIPEAKW-UHFFFAOYSA-N,"c(""Acetylcholinesterase"", ""Butyrylcholinesterase"", ""Acyl coenzyme A:cholesterol acyltransferase"", ""Unchecked"", ""Dual specificity phosphatase Cdc25A"")",1066,EST1,,extracellular space GO:0005615 IBA endoplasmic reticulum lumen GO:0005788 TAS,TAS GO:0006805 xenobiotic metabolic process TAS 1918003 metabolic process GO:0008152 TAS 1918003 response to toxic substance GO:0009636 IDA 21492153 epithelial cell differentiation GO:0030855,IEA GO:0047374 methylumbelliferyl-acetate deacetylase activity TAS GO:0052689 carboxylic ester hydrolase activity,Drug metabolism - other enzymes - Homo sapiens (human) hsa00983,CHEMBL CHEMBL2334539,O75908,Acyl coenzyme A:cholesterol acyltransferase 2,1.0,PRIMARY,NO,CC(=O)OC[C@]1(C)[C@H](CC[C@@]2(C)[C@H]1C[C@H](OC(=O)c3ccc(cc3)C#N)[C@@]4(C)OC5=C([C@H](O)[C@H]24)C(=O)OC(=C5)c6cccnc6)OC(=O)C,2,6,"InChI=1S/C37H38N2O10/c1-20(40)45-19-36(4)27-16-29(48-33(43)23-10-8-22(17-38)9-11-23)37(5)32(35(27,3)13-12-28(36)46-21(2)41)31(42)30-26(49-37)15-25(47-34(30)44)24-7-6-14-39-18-24/h6-11,14-15,18,27-29,31-32,42H,12-13,16,19H2,1-5H3/t27-,28+,29+,31+,32-,35+,36+,37-/m1/s1",HBSJDWOXHMSOQS-ZRPSWOMSSA-N,"c(""Unchecked"", ""Acyl coenzyme A:cholesterol acyltransferase 2"", ""Acyl coenzyme A:cholesterol acyltransferase 1"")",8435,SOAT2,,15451793 GO:0005783 endoplasmic reticulum IDA 12808042 GO:0005789 endoplasmic reticulum membrane IDA 14615411 GO:0005903 brush border IDA GO:0016021 integral component of membrane IEA,16647063 IDA GO:0008203 cholesterol metabolic process 14615411 TAS GO:0010742 macrophage derived foam cell differentiation 14615411 IC GO:0030299 intestinal cholesterol absorption 15308631 IMP GO:0033344 cholesterol efflux 15308631 IMP GO:0034379 very-low-density lipoprotein particle assembly 16647063 IDA GO:0034435 cholesterol esterification 11401500 TAS GO:0042632 cholesterol homeostasis,"16647063 IDA GO:0000062 fatty-acyl-CoA binding 16647063 IDA GO:0015485 cholesterol binding 9756920 TAS GO:0016746 transferase activity, transferring acyl groups 16647063 IDA GO:0034736 cholesterol O-acyltransferase activity",hsa00100 Steroid biosynthesis - Homo sapiens (human),CHEMBL CHEMBL253665,O14672,ADAM10,1.0,PRIMARY,NO,Cc1cc(ccc1C2CCN(CC2)S(=O)(=O)CC3(CCN(CC3)C(=O)O[C@H]4CCOC4)C(=O)NO)C#N,5,6,"InChI=1S/C25H34N4O7S/c1-18-14-19(15-26)2-3-22(18)20-4-9-29(10-5-20)37(33,34)17-25(23(30)27-32)7-11-28(12-8-25)24(31)36-21-6-13-35-16-21/h2-3,14,20-21,32H,4-13,16-17H2,1H3,(H,27,30)/t21-/m0/s1",IVYQYYDKKZBNTO-NRFANRHFSA-N,"c(""ADAM10"", ""Matrix metalloproteinase-2"", ""Matrix metalloproteinase-1"", ""Matrix metalloproteinase 3"", ""Matrix metalloproteinase 9"")",102,ADA10,R-HSA-1442490 Collagen degradation R-HSA-1474228 Degradation of the extracellular matrix R-HSA-1474244 Extracellular matrix organization R-HSA-156988 Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor R-HSA-157118 Signaling by NOTCH R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-177929 Signaling by EGFR R-HSA-1980143 Signaling by NOTCH1 R-HSA-1980145 Signaling by NOTCH2 R-HSA-1980148 Signaling by NOTCH3 R-HSA-1980150 Signaling by NOTCH4 R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603 Signaling by NOTCH1 in Cancer R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-5663202 Diseases of signal transduction,nucleus ISS GO:0005634 cytoplasm ISS GO:0005737 Golgi apparatus IDA 12475894 GO:0005794 Golgi-associated vesicle IDA 12475894 GO:0005798 trans-Golgi network IEA GO:0005802 plasma membrane TAS GO:0005886 focal adhesion IDA 21423176 GO:0005925 cell surface IDA 12475894 23035126 23091066 GO:0009986 postsynaptic density IEA GO:0014069 membrane IDA 19946888 GO:0016020 integral component of membrane NAS 8694785 GO:0016021 intracellular membrane-bounded organelle IDA GO:0043231 extracellular exosome IDA 20458337 GO:0070062 perinuclear endoplasmic reticulum IDA 23091066 GO:0097038 tetraspanin-enriched microdomain IDA 23035126 GO:0097197,in utero embryonic development GO:0001701 ISS protein phosphorylation GO:0006468 ISS membrane protein ectodomain proteolysis GO:0006509 12714508 17557115 18355449 18419754 18676862 19114711 IDA membrane protein ectodomain proteolysis GO:0006509 17965014 18355445 18373975 IMP negative regulation of cell adhesion GO:0007162 12714508 IDA negative regulation of cell adhesion GO:0007162 8694785 NAS Notch signaling pathway GO:0007219 ISS Notch signaling pathway GO:0007219 TAS Notch receptor processing GO:0007220 TAS integrin-mediated signaling pathway GO:0007229 8694785 NAS cell-cell signaling GO:0007267 12714508 NAS positive regulation of cell proliferation GO:0008284 18373975 IMP positive regulation of T cell chemotaxis GO:0010820 18373975 IMP protein processing GO:0016485 IEA extracellular matrix disassembly GO:0022617 TAS positive regulation of cell growth GO:0030307 18373975 IMP positive regulation of cell migration GO:0030335 18373975 IMP response to tumor necrosis factor GO:0034612 11831872 IDA monocyte activation GO:0042117 11831872 IMP ephrin receptor signaling pathway GO:0048013 TAS PMA-inducible membrane protein ectodomain proteolysis GO:0051088 18676862 IMP constitutive protein ectodomain proteolysis GO:0051089 12714508 IDA,endopeptidase activity GO:0004175 ISS metalloendopeptidase activity GO:0004222 19114711 IMP metalloendopeptidase activity GO:0004222 8694785 NAS metalloendopeptidase activity GO:0004222 TAS receptor binding GO:0005102 12176995 NAS integrin binding GO:0005178 8694785 NAS protein binding GO:0005515 10527948 15280379 23091066 IPI metallopeptidase activity GO:0008237 12475894 IDA metallopeptidase activity GO:0008237 12535668 IMP metallopeptidase activity GO:0008237 TAS zinc ion binding GO:0008270 IEA SH3 domain binding GO:0017124 IEA protein kinase binding GO:0019901 ISS protein homodimerization activity GO:0042803 ISS,"Alzheimer,s disease - Homo sapiens (human) hsa05010 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) hsa05120",CHEMBL CHEMBL2431028,P78536,ADAM17,1.0,ORTHOGONAL,NO,NC(=O)NCCC[C@@H](NS(=O)(=O)c1ccc(OCc2cc(Br)cc(Br)c2)cc1)C(=O)NO,5,14,"InChI=1S/C19H22Br2N4O6S/c20-13-8-12(9-14(21)10-13)11-31-15-3-5-16(6-4-15)32(29,30)25-17(18(26)24-28)2-1-7-23-19(22)27/h3-6,8-10,17,25,28H,1-2,7,11H2,(H,24,26)(H3,22,23,27)/t17-/m1/s1",QTXVPJOTKLUYMQ-QGZVFWFLSA-N,"c(""ADAM17"", ""Unchecked"", ""Matrix metalloproteinase 9"", ""ADAM10"", ""Matrix metalloproteinase 14"", ""Matrix metalloproteinase-2"")",6868,ADA17,Signaling by ERBB4 R-HSA-1236394 Nuclear signaling by ERBB4 R-HSA-1251985 Cytokine Signaling in Immune system R-HSA-1280215 Collagen degradation R-HSA-1442490 Degradation of the extracellular matrix R-HSA-1474228 Extracellular matrix organization R-HSA-1474244 Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor R-HSA-156988 Signaling by NOTCH R-HSA-157118 Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Signalling by NGF R-HSA-166520 Immune System R-HSA-168256 Signaling by EGFR R-HSA-177929 Regulated proteolysis of p75NTR R-HSA-193692 p75 NTR receptor-mediated signalling R-HSA-193704 Signaling by NOTCH1 R-HSA-1980143 Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 Signaling by NOTCH1 in Cancer R-HSA-2644603 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 Hedgehog ligand biogenesis R-HSA-5358346 Signaling by Hedgehog R-HSA-5358351 Release of Hh-Np from the secreting cell R-HSA-5362798 Diseases of signal transduction R-HSA-5663202 Death Receptor Signalling R-HSA-73887 TNF signaling R-HSA-75893 Growth hormone receptor signaling R-HSA-982772,GO:0005737 cytoplasm IDA GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 17786981 IDA GO:0005911 cell-cell junction colocalizes_with 14970227 IDA GO:0005925 focal adhesion colocalizes_with 14970227 IDA GO:0009986 cell surface 9034190 18383040 18625725 IDA GO:0015629 actin cytoskeleton 17010968 IDA GO:0016020 membrane 19946888 IDA GO:0016324 apical plasma membrane 16034137 IDA GO:0032587 ruffle membrane colocalizes_with 14970227 IDA GO:0045121 membrane raft 17010968 17786981 IDA,"response to hypoxia 18276953 GO:0001666 IDA positive regulation of protein phosphorylation 18625725 GO:0001934 IMP neutrophil mediated immunity 16034137 GO:0002446 IC germinal center formation 10433800 GO:0002467 ISS positive regulation of leukocyte chemotaxis 16034137 GO:0002690 IC proteolysis 24227843 GO:0006508 IDA membrane protein ectodomain proteolysis 9034190 9574564 17786981 18676862 GO:0006509 IDA membrane protein ectodomain proteolysis 9034191 12743035 16034137 18373975 21170088 GO:0006509 IMP cell adhesion 14970227 GO:0007155 IDA epidermal growth factor receptor signaling pathway 12743035 GO:0007173 IDA Notch signaling pathway GO:0007219 IEA Notch receptor processing 24226769 GO:0007220 IDA positive regulation of cell proliferation 18373975 GO:0008284 IMP positive regulation of T cell chemotaxis 18373975 GO:0010820 IMP B cell differentiation 10433800 GO:0030183 ISS positive regulation of cell growth 18373975 GO:0030307 IMP positive regulation of cell migration 18373975 GO:0030335 IMP positive regulation of transforming growth factor beta receptor signaling pathway 10433800 GO:0030511 ISS negative regulation of transforming growth factor beta receptor signaling pathway 21170088 GO:0030512 IMP membrane protein intracellular domain proteolysis GO:0031293 TAS positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle 18483258 GO:0031659 IDA response to lipopolysaccharide 18383040 GO:0032496 IDA positive regulation of chemokine production 16034137 GO:0032722 IMP regulation of mast cell apoptotic process 10433800 GO:0033025 ISS T cell differentiation in thymus 10433800 GO:0033077 ISS tumor necrosis factor-mediated signaling pathway GO:0033209 TAS cell adhesion mediated by integrin 14970227 GO:0033627 IDA wound healing, spreading of epidermal cells 14970227 GO:0035313 IEP epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway 17655843 GO:0035625 IMP response to drug 10433800 GO:0042493 ISS positive regulation of epidermal growth factor-activated receptor activity 18483258 GO:0045741 IDA positive regulation of epidermal growth factor-activated receptor activity 17655843 GO:0045741 IMP spleen development 10433800 GO:0048536 ISS cell motility 10433800 GO:0048870 ISS defense response to Gram-positive bacterium 16034137 GO:0050830 IMP PMA-inducible membrane protein ectodomain proteolysis 14625290 15691827 17010968 GO:0051088 IDA PMA-inducible membrane protein ectodomain proteolysis 18676862 GO:0051088 IMP positive regulation of cellular component movement 10433800 GO:0051272 ISS response to high density lipoprotein particle 17786981 GO:0055099 IDA",metalloendopeptidase activity 9920899 24226769 GO:0004222 IDA metalloendopeptidase activity 9034190 9034191 GO:0004222 IMP metalloendopeptidase activity GO:0004222 TAS Notch binding 24226769 GO:0005112 IDA interleukin-6 receptor binding 16034137 GO:0005138 IPI integrin binding 14970227 GO:0005178 IPI protein binding 10527948 12668732 15280379 18355445 18625725 18638486 GO:0005515 IPI metallopeptidase activity 12777399 GO:0008237 IDA metallopeptidase activity 12535668 GO:0008237 IMP metallopeptidase activity GO:0008237 TAS zinc ion binding GO:0008270 IEA SH3 domain binding GO:0017124 IEA PDZ domain binding 12207026 GO:0030165 IPI,"hsa04330 Notch signaling pathway - Homo sapiens (human) hsa05010 Alzheimer,s disease - Homo sapiens (human) hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)",CHEMBL CHEMBL209970,P78536,ADAM17,1.0,PRIMARY,NO,CC#CCOc1ccc(cc1)S(=O)(=O)CC2(CCN(CC2)S(=O)(=O)C(C)C)C(=O)NO,6,34,"InChI=1S/C20H28N2O7S2/c1-4-5-14-29-17-6-8-18(9-7-17)30(25,26)15-20(19(23)21-24)10-12-22(13-11-20)31(27,28)16(2)3/h6-9,16,24H,10-15H2,1-3H3,(H,21,23)",CEVLUPQNDFOYSI-UHFFFAOYSA-N,"c(""Unchecked"", ""Homo sapiens"", ""Matrix metalloproteinase 14"", ""Matrix metalloproteinase 13"", ""Matrix metalloproteinase 9"", ""Matrix metalloproteinase-2"", ""Matrix metalloproteinase-1"", ""ADAM17"")",6868,ADA17,Signaling by ERBB4 R-HSA-1236394 Nuclear signaling by ERBB4 R-HSA-1251985 Cytokine Signaling in Immune system R-HSA-1280215 Collagen degradation R-HSA-1442490 Degradation of the extracellular matrix R-HSA-1474228 Extracellular matrix organization R-HSA-1474244 Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor R-HSA-156988 Signaling by NOTCH R-HSA-157118 Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Signalling by NGF R-HSA-166520 Immune System R-HSA-168256 Signaling by EGFR R-HSA-177929 Regulated proteolysis of p75NTR R-HSA-193692 p75 NTR receptor-mediated signalling R-HSA-193704 Signaling by NOTCH1 R-HSA-1980143 Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-2122948 Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 Signaling by NOTCH1 in Cancer R-HSA-2644603 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660825 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant R-HSA-2660826 Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2691230 Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2691232 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 Hedgehog ligand biogenesis R-HSA-5358346 Signaling by Hedgehog R-HSA-5358351 Release of Hh-Np from the secreting cell R-HSA-5362798 Diseases of signal transduction R-HSA-5663202 Death Receptor Signalling R-HSA-73887 TNF signaling R-HSA-75893 Growth hormone receptor signaling R-HSA-982772,GO:0005737 cytoplasm IDA GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 17786981 IDA GO:0005911 cell-cell junction colocalizes_with 14970227 IDA GO:0005925 focal adhesion colocalizes_with 14970227 IDA GO:0009986 cell surface 9034190 18383040 18625725 IDA GO:0015629 actin cytoskeleton 17010968 IDA GO:0016020 membrane 19946888 IDA GO:0016324 apical plasma membrane 16034137 IDA GO:0032587 ruffle membrane colocalizes_with 14970227 IDA GO:0045121 membrane raft 17010968 17786981 IDA,"response to hypoxia 18276953 GO:0001666 IDA positive regulation of protein phosphorylation 18625725 GO:0001934 IMP neutrophil mediated immunity 16034137 GO:0002446 IC germinal center formation 10433800 GO:0002467 ISS positive regulation of leukocyte chemotaxis 16034137 GO:0002690 IC proteolysis 24227843 GO:0006508 IDA membrane protein ectodomain proteolysis 9034190 9574564 17786981 18676862 GO:0006509 IDA membrane protein ectodomain proteolysis 9034191 12743035 16034137 18373975 21170088 GO:0006509 IMP cell adhesion 14970227 GO:0007155 IDA epidermal growth factor receptor signaling pathway 12743035 GO:0007173 IDA Notch signaling pathway GO:0007219 IEA Notch receptor processing 24226769 GO:0007220 IDA positive regulation of cell proliferation 18373975 GO:0008284 IMP positive regulation of T cell chemotaxis 18373975 GO:0010820 IMP B cell differentiation 10433800 GO:0030183 ISS positive regulation of cell growth 18373975 GO:0030307 IMP positive regulation of cell migration 18373975 GO:0030335 IMP positive regulation of transforming growth factor beta receptor signaling pathway 10433800 GO:0030511 ISS negative regulation of transforming growth factor beta receptor signaling pathway 21170088 GO:0030512 IMP membrane protein intracellular domain proteolysis GO:0031293 TAS positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle 18483258 GO:0031659 IDA response to lipopolysaccharide 18383040 GO:0032496 IDA positive regulation of chemokine production 16034137 GO:0032722 IMP regulation of mast cell apoptotic process 10433800 GO:0033025 ISS T cell differentiation in thymus 10433800 GO:0033077 ISS tumor necrosis factor-mediated signaling pathway GO:0033209 TAS cell adhesion mediated by integrin 14970227 GO:0033627 IDA wound healing, spreading of epidermal cells 14970227 GO:0035313 IEP epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway 17655843 GO:0035625 IMP response to drug 10433800 GO:0042493 ISS positive regulation of epidermal growth factor-activated receptor activity 18483258 GO:0045741 IDA positive regulation of epidermal growth factor-activated receptor activity 17655843 GO:0045741 IMP spleen development 10433800 GO:0048536 ISS cell motility 10433800 GO:0048870 ISS defense response to Gram-positive bacterium 16034137 GO:0050830 IMP PMA-inducible membrane protein ectodomain proteolysis 14625290 15691827 17010968 GO:0051088 IDA PMA-inducible membrane protein ectodomain proteolysis 18676862 GO:0051088 IMP positive regulation of cellular component movement 10433800 GO:0051272 ISS response to high density lipoprotein particle 17786981 GO:0055099 IDA",metalloendopeptidase activity 9920899 24226769 GO:0004222 IDA metalloendopeptidase activity 9034190 9034191 GO:0004222 IMP metalloendopeptidase activity GO:0004222 TAS Notch binding 24226769 GO:0005112 IDA interleukin-6 receptor binding 16034137 GO:0005138 IPI integrin binding 14970227 GO:0005178 IPI protein binding 10527948 12668732 15280379 18355445 18625725 18638486 GO:0005515 IPI metallopeptidase activity 12777399 GO:0008237 IDA metallopeptidase activity 12535668 GO:0008237 IMP metallopeptidase activity GO:0008237 TAS zinc ion binding GO:0008270 IEA SH3 domain binding GO:0017124 IEA PDZ domain binding 12207026 GO:0030165 IPI,"hsa04330 Notch signaling pathway - Homo sapiens (human) hsa05010 Alzheimer,s disease - Homo sapiens (human) hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)",CHEMBL CHEMBL2164094,Q9UNA0,ADAMTS5,1.0,PRIMARY,NO,CCCNc1nc(NCc2cn(C)cn2)nc(n1)N3CCC[C@@H]3CNS(=O)(=O)c4ccc(CCC)cc4,5,9,"InChI=1S/C25H37N9O2S/c1-4-7-19-9-11-22(12-10-19)37(35,36)29-16-21-8-6-14-34(21)25-31-23(26-13-5-2)30-24(32-25)27-15-20-17-33(3)18-28-20/h9-12,17-18,21,29H,4-8,13-16H2,1-3H3,(H2,26,27,30,31,32)/t21-/m1/s1",RNVLUWRPULKASN-OAQYLSRUSA-N,"c(""Unchecked"", ""ADAMTS1"", ""Matrix metalloproteinase 13"", ""ADAM17"", ""ADAMTS4"", ""ADAMTS5"")",11096,ATS5,R-HSA-1474228 Degradation of the extracellular matrix R-HSA-1474244 Extracellular matrix organization R-HSA-392499 Metabolism of proteins R-HSA-5173105 O-linked glycosylation R-HSA-5173214 O-glycosylation of TSR domain-containing proteins R-HSA-597592 Post-translational protein modification,extracellular region GO:0005576 TAS proteinaceous extracellular matrix GO:0005578 IEA extracellular space GO:0005615 IEA endoplasmic reticulum lumen GO:0005788 TAS,GO:0006508 proteolysis IEA GO:0022617 extracellular matrix disassembly TAS GO:0036066 protein O-linked fucosylation TAS GO:0042742 defense response to bacterium IEA,GO:0004222 metalloendopeptidase activity TAS 10438522 GO:0005178 integrin binding TAS 22406378 GO:0005515 protein binding IPI GO:0008201 heparin binding IEA 10438522 GO:0008237 metallopeptidase activity TAS GO:0008270 zinc ion binding IEA GO:0050840 extracellular matrix binding IEA,,CHEMBL CHEMBL219160,P30542,Adenosine A1 receptor,1.0,ORTHOGONAL,NO,C1CCC(CC1)c2nc3c(cc(nc3[nH]2)c4ccccc4)c5ccccc5,4,7,"InChI=1S/C24H23N3/c1-4-10-17(11-5-1)20-16-21(18-12-6-2-7-13-18)25-24-22(20)26-23(27-24)19-14-8-3-9-15-19/h1-2,4-7,10-13,16,19H,3,8-9,14-15H2,(H,25,26,27)",DXBBMCIVYYJMJC-UHFFFAOYSA-N,"c(""Adenosine A1 receptor"", ""Adenosine A2a receptor"", ""Adenosine A3 receptor"", ""Adenosine receptors; A1 & A2a"", ""Adenosine receptors; A1 & A3"", ""Adenosine A2b receptor"")",134,AA1R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 Adenosine P1 receptors R-HSA-417973 Nucleotide-like (purinergic) receptors R-HSA-418038 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,IEA GO:0005783 endoplasmic reticulum TAS GO:0005886 plasma membrane TAS 1530647 integral component of plasma membrane GO:0005887 IEA GO:0014069 postsynaptic density IEA GO:0016323 basolateral plasma membrane IEA GO:0030673 axolemma IEA GO:0032279 asymmetric synapse IEA GO:0042734 presynaptic membrane IEA GO:0043025 neuronal cell body IEA GO:0043195 terminal bouton IEA GO:0043197 dendritic spine IEA GO:0045211 postsynaptic membrane IEA GO:0048786 presynaptic active zone,"activation of MAPKK activity IEA GO:0000186 temperature homeostasis IEA GO:0001659 response to hypoxia IEA GO:0001666 adenosine receptor signaling pathway IEA GO:0001973 regulation of respiratory gaseous exchange by neurological system process IEA GO:0002087 negative regulation of acute inflammatory response IEA GO:0002674 negative regulation of leukocyte migration IEA GO:0002686 positive regulation of peptide secretion IEA GO:0002793 regulation of glomerular filtration IEA GO:0003093 protein targeting to membrane IEA GO:0006612 phagocytosis TAS 8360491 GO:0006909 inflammatory response TAS 8360491 GO:0006954 signal transduction TAS 1530647 GO:0007165 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA GO:0007193 cell-cell signaling TAS 7818494 GO:0007267 nervous system development TAS 8450977 GO:0007399 negative regulation of cell proliferation IEA GO:0008285 negative regulation of glutamate secretion IEA GO:0014050 lipid catabolic process IEA GO:0016042 negative regulation of synaptic transmission, GABAergic IEA GO:0032229 positive regulation of nucleoside transport IEA GO:0032244 negative regulation of neurotrophin production IEA GO:0032900 positive regulation of protein dephosphorylation IEA GO:0035307 negative regulation of renal sodium excretion IEA GO:0035814 negative regulation of circadian sleep/wake cycle, non-REM sleep IEA GO:0042323 negative regulation of apoptotic process IEA GO:0043066 positive regulation of potassium ion transport IEA GO:0043268 positive regulation of epidermal growth factor-activated receptor activity IEA GO:0045741 negative regulation of blood pressure IEA GO:0045776 positive regulation of blood pressure IEA GO:0045777 negative regulation of vasodilation IEA GO:0045908 negative regulation of hormone secretion IEA GO:0046888 cognition IEA GO:0050890 detection of temperature stimulus involved in sensory perception of pain IEA GO:0050965 negative regulation of lipid catabolic process IEA GO:0050995 regulation of sensory perception of pain IEA GO:0051930 negative regulation of synaptic transmission, glutamatergic IEA GO:0051967 negative regulation of cardiac muscle contraction IEA GO:0055118 excitatory postsynaptic potential IEA GO:0060079 relaxation of vascular smooth muscle IEA GO:0060087 negative regulation of mucus secretion IEA GO:0070256 apoptotic signaling pathway TAS 7818494 GO:0097190 negative regulation of long term synaptic depression IEA GO:1900453",G-protein coupled adenosine receptor activity IEA GO:0001609 G-protein coupled receptor binding IEA GO:0001664 purine nucleoside binding IEA GO:0001883 phospholipase C activity IEA GO:0004629 protein binding IPI 16481441 GO:0005515 heat shock protein binding IEA GO:0031072 G-protein beta/gamma-subunit complex binding IEA GO:0031683 heterotrimeric G-protein binding IEA GO:0032795 protein heterodimerization activity IEA GO:0046982,cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 cAMP signaling pathway - Homo sapiens (human) hsa04024 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04923 Renin secretion - Homo sapiens (human) hsa04924 Morphine addiction - Homo sapiens (human) hsa05032,CHEMBL CHEMBL2113457,P30542,Adenosine A1 receptor,1.0,PRIMARY,NO,OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(NC4CCCC4)nc(N=NNC(=O)Nc5ccccc5)nc23,4,10,"InChI=1S/C22H27N9O5/c32-10-14-16(33)17(34)20(36-14)31-11-23-15-18(24-12-8-4-5-9-12)26-21(27-19(15)31)28-30-29-22(35)25-13-6-2-1-3-7-13/h1-3,6-7,11-12,14,16-17,20,32-34H,4-5,8-10H2,(H3,24,25,26,27,28,29,35)/t14-,16-,17-,20-/m1/s1",RZJAODYQRFMAKN-WVSUBDOOSA-N,"c(""Adenosine A1 receptor"", ""Adenosine A2a receptor"", ""Adenosine A3 receptor"", ""Adenosine A2b receptor"", ""Adenosine receptors; A1 & A2a"", ""Adenosine receptors; A1 & A3"")",134,AA1R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 Adenosine P1 receptors R-HSA-417973 Nucleotide-like (purinergic) receptors R-HSA-418038 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,IEA GO:0005783 endoplasmic reticulum TAS GO:0005886 plasma membrane TAS 1530647 integral component of plasma membrane GO:0005887 IEA GO:0014069 postsynaptic density IEA GO:0016323 basolateral plasma membrane IEA GO:0030673 axolemma IEA GO:0032279 asymmetric synapse IEA GO:0042734 presynaptic membrane IEA GO:0043025 neuronal cell body IEA GO:0043195 terminal bouton IEA GO:0043197 dendritic spine IEA GO:0045211 postsynaptic membrane IEA GO:0048786 presynaptic active zone,"activation of MAPKK activity IEA GO:0000186 temperature homeostasis IEA GO:0001659 response to hypoxia IEA GO:0001666 adenosine receptor signaling pathway IEA GO:0001973 regulation of respiratory gaseous exchange by neurological system process IEA GO:0002087 negative regulation of acute inflammatory response IEA GO:0002674 negative regulation of leukocyte migration IEA GO:0002686 positive regulation of peptide secretion IEA GO:0002793 regulation of glomerular filtration IEA GO:0003093 protein targeting to membrane IEA GO:0006612 phagocytosis TAS 8360491 GO:0006909 inflammatory response TAS 8360491 GO:0006954 signal transduction TAS 1530647 GO:0007165 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA GO:0007193 cell-cell signaling TAS 7818494 GO:0007267 nervous system development TAS 8450977 GO:0007399 negative regulation of cell proliferation IEA GO:0008285 negative regulation of glutamate secretion IEA GO:0014050 lipid catabolic process IEA GO:0016042 negative regulation of synaptic transmission, GABAergic IEA GO:0032229 positive regulation of nucleoside transport IEA GO:0032244 negative regulation of neurotrophin production IEA GO:0032900 positive regulation of protein dephosphorylation IEA GO:0035307 negative regulation of renal sodium excretion IEA GO:0035814 negative regulation of circadian sleep/wake cycle, non-REM sleep IEA GO:0042323 negative regulation of apoptotic process IEA GO:0043066 positive regulation of potassium ion transport IEA GO:0043268 positive regulation of epidermal growth factor-activated receptor activity IEA GO:0045741 negative regulation of blood pressure IEA GO:0045776 positive regulation of blood pressure IEA GO:0045777 negative regulation of vasodilation IEA GO:0045908 negative regulation of hormone secretion IEA GO:0046888 cognition IEA GO:0050890 detection of temperature stimulus involved in sensory perception of pain IEA GO:0050965 negative regulation of lipid catabolic process IEA GO:0050995 regulation of sensory perception of pain IEA GO:0051930 negative regulation of synaptic transmission, glutamatergic IEA GO:0051967 negative regulation of cardiac muscle contraction IEA GO:0055118 excitatory postsynaptic potential IEA GO:0060079 relaxation of vascular smooth muscle IEA GO:0060087 negative regulation of mucus secretion IEA GO:0070256 apoptotic signaling pathway TAS 7818494 GO:0097190 negative regulation of long term synaptic depression IEA GO:1900453",G-protein coupled adenosine receptor activity IEA GO:0001609 G-protein coupled receptor binding IEA GO:0001664 purine nucleoside binding IEA GO:0001883 phospholipase C activity IEA GO:0004629 protein binding IPI 16481441 GO:0005515 heat shock protein binding IEA GO:0031072 G-protein beta/gamma-subunit complex binding IEA GO:0031683 heterotrimeric G-protein binding IEA GO:0032795 protein heterodimerization activity IEA GO:0046982,cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 cAMP signaling pathway - Homo sapiens (human) hsa04024 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04923 Renin secretion - Homo sapiens (human) hsa04924 Morphine addiction - Homo sapiens (human) hsa05032,CHEMBL CHEMBL2163568,P30542,Adenosine A1 receptor,1.0,ORTHOGONAL,YES,OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N[C@H]4CCC[C@@H]4O)ncnc23,4,10,"InChI=1S/C15H21N5O5/c21-4-9-11(23)12(24)15(25-9)20-6-18-10-13(16-5-17-14(10)20)19-7-2-1-3-8(7)22/h5-9,11-12,15,21-24H,1-4H2,(H,16,17,19)/t7-,8-,9+,11+,12+,15+/m0/s1",GYWXTRVEUURNEW-TVDBPQCTSA-N,"c(""Adenosine A1 receptor"", ""Adenosine A3 receptor"", ""Adenosine A2b receptor"", ""Adenosine A2a receptor"")",134,AA1R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 Adenosine P1 receptors R-HSA-417973 Nucleotide-like (purinergic) receptors R-HSA-418038 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,IEA GO:0005783 endoplasmic reticulum TAS GO:0005886 plasma membrane TAS 1530647 integral component of plasma membrane GO:0005887 IEA GO:0014069 postsynaptic density IEA GO:0016323 basolateral plasma membrane IEA GO:0030673 axolemma IEA GO:0032279 asymmetric synapse IEA GO:0042734 presynaptic membrane IEA GO:0043025 neuronal cell body IEA GO:0043195 terminal bouton IEA GO:0043197 dendritic spine IEA GO:0045211 postsynaptic membrane IEA GO:0048786 presynaptic active zone,"activation of MAPKK activity IEA GO:0000186 temperature homeostasis IEA GO:0001659 response to hypoxia IEA GO:0001666 adenosine receptor signaling pathway IEA GO:0001973 regulation of respiratory gaseous exchange by neurological system process IEA GO:0002087 negative regulation of acute inflammatory response IEA GO:0002674 negative regulation of leukocyte migration IEA GO:0002686 positive regulation of peptide secretion IEA GO:0002793 regulation of glomerular filtration IEA GO:0003093 protein targeting to membrane IEA GO:0006612 phagocytosis TAS 8360491 GO:0006909 inflammatory response TAS 8360491 GO:0006954 signal transduction TAS 1530647 GO:0007165 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA GO:0007193 cell-cell signaling TAS 7818494 GO:0007267 nervous system development TAS 8450977 GO:0007399 negative regulation of cell proliferation IEA GO:0008285 negative regulation of glutamate secretion IEA GO:0014050 lipid catabolic process IEA GO:0016042 negative regulation of synaptic transmission, GABAergic IEA GO:0032229 positive regulation of nucleoside transport IEA GO:0032244 negative regulation of neurotrophin production IEA GO:0032900 positive regulation of protein dephosphorylation IEA GO:0035307 negative regulation of renal sodium excretion IEA GO:0035814 negative regulation of circadian sleep/wake cycle, non-REM sleep IEA GO:0042323 negative regulation of apoptotic process IEA GO:0043066 positive regulation of potassium ion transport IEA GO:0043268 positive regulation of epidermal growth factor-activated receptor activity IEA GO:0045741 negative regulation of blood pressure IEA GO:0045776 positive regulation of blood pressure IEA GO:0045777 negative regulation of vasodilation IEA GO:0045908 negative regulation of hormone secretion IEA GO:0046888 cognition IEA GO:0050890 detection of temperature stimulus involved in sensory perception of pain IEA GO:0050965 negative regulation of lipid catabolic process IEA GO:0050995 regulation of sensory perception of pain IEA GO:0051930 negative regulation of synaptic transmission, glutamatergic IEA GO:0051967 negative regulation of cardiac muscle contraction IEA GO:0055118 excitatory postsynaptic potential IEA GO:0060079 relaxation of vascular smooth muscle IEA GO:0060087 negative regulation of mucus secretion IEA GO:0070256 apoptotic signaling pathway TAS 7818494 GO:0097190 negative regulation of long term synaptic depression IEA GO:1900453",G-protein coupled adenosine receptor activity IEA GO:0001609 G-protein coupled receptor binding IEA GO:0001664 purine nucleoside binding IEA GO:0001883 phospholipase C activity IEA GO:0004629 protein binding IPI 16481441 GO:0005515 heat shock protein binding IEA GO:0031072 G-protein beta/gamma-subunit complex binding IEA GO:0031683 heterotrimeric G-protein binding IEA GO:0032795 protein heterodimerization activity IEA GO:0046982,cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 cAMP signaling pathway - Homo sapiens (human) hsa04024 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04923 Renin secretion - Homo sapiens (human) hsa04924 Morphine addiction - Homo sapiens (human) hsa05032,CHEMBL CHEMBL3613119,P30542,Adenosine A1 receptor,1.0,PRIMARY,YES,COc1ccc(cc1)c2c(C#N)c(N)nc(SCc3csc(n3)c4ccc(Cl)cc4)c2C#N,4,12,"InChI=1S/C24H16ClN5OS2/c1-31-18-8-4-14(5-9-18)21-19(10-26)22(28)30-24(20(21)11-27)33-13-17-12-32-23(29-17)15-2-6-16(25)7-3-15/h2-9,12H,13H2,1H3,(H2,28,30)",TVXHJIDNWXNUMN-UHFFFAOYSA-N,"c(""Unchecked"", ""Adenosine A1 receptor"", ""Adenosine A3 receptor"", ""Adenosine A2b receptor"", ""Adenosine A2a receptor"")",134,AA1R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 Adenosine P1 receptors R-HSA-417973 Nucleotide-like (purinergic) receptors R-HSA-418038 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,IEA GO:0005783 endoplasmic reticulum TAS GO:0005886 plasma membrane TAS 1530647 integral component of plasma membrane GO:0005887 IEA GO:0014069 postsynaptic density IEA GO:0016323 basolateral plasma membrane IEA GO:0030673 axolemma IEA GO:0032279 asymmetric synapse IEA GO:0042734 presynaptic membrane IEA GO:0043025 neuronal cell body IEA GO:0043195 terminal bouton IEA GO:0043197 dendritic spine IEA GO:0045211 postsynaptic membrane IEA GO:0048786 presynaptic active zone,"activation of MAPKK activity IEA GO:0000186 temperature homeostasis IEA GO:0001659 response to hypoxia IEA GO:0001666 adenosine receptor signaling pathway IEA GO:0001973 regulation of respiratory gaseous exchange by neurological system process IEA GO:0002087 negative regulation of acute inflammatory response IEA GO:0002674 negative regulation of leukocyte migration IEA GO:0002686 positive regulation of peptide secretion IEA GO:0002793 regulation of glomerular filtration IEA GO:0003093 protein targeting to membrane IEA GO:0006612 phagocytosis TAS 8360491 GO:0006909 inflammatory response TAS 8360491 GO:0006954 signal transduction TAS 1530647 GO:0007165 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA GO:0007193 cell-cell signaling TAS 7818494 GO:0007267 nervous system development TAS 8450977 GO:0007399 negative regulation of cell proliferation IEA GO:0008285 negative regulation of glutamate secretion IEA GO:0014050 lipid catabolic process IEA GO:0016042 negative regulation of synaptic transmission, GABAergic IEA GO:0032229 positive regulation of nucleoside transport IEA GO:0032244 negative regulation of neurotrophin production IEA GO:0032900 positive regulation of protein dephosphorylation IEA GO:0035307 negative regulation of renal sodium excretion IEA GO:0035814 negative regulation of circadian sleep/wake cycle, non-REM sleep IEA GO:0042323 negative regulation of apoptotic process IEA GO:0043066 positive regulation of potassium ion transport IEA GO:0043268 positive regulation of epidermal growth factor-activated receptor activity IEA GO:0045741 negative regulation of blood pressure IEA GO:0045776 positive regulation of blood pressure IEA GO:0045777 negative regulation of vasodilation IEA GO:0045908 negative regulation of hormone secretion IEA GO:0046888 cognition IEA GO:0050890 detection of temperature stimulus involved in sensory perception of pain IEA GO:0050965 negative regulation of lipid catabolic process IEA GO:0050995 regulation of sensory perception of pain IEA GO:0051930 negative regulation of synaptic transmission, glutamatergic IEA GO:0051967 negative regulation of cardiac muscle contraction IEA GO:0055118 excitatory postsynaptic potential IEA GO:0060079 relaxation of vascular smooth muscle IEA GO:0060087 negative regulation of mucus secretion IEA GO:0070256 apoptotic signaling pathway TAS 7818494 GO:0097190 negative regulation of long term synaptic depression IEA GO:1900453",G-protein coupled adenosine receptor activity IEA GO:0001609 G-protein coupled receptor binding IEA GO:0001664 purine nucleoside binding IEA GO:0001883 phospholipase C activity IEA GO:0004629 protein binding IPI 16481441 GO:0005515 heat shock protein binding IEA GO:0031072 G-protein beta/gamma-subunit complex binding IEA GO:0031683 heterotrimeric G-protein binding IEA GO:0032795 protein heterodimerization activity IEA GO:0046982,cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 cAMP signaling pathway - Homo sapiens (human) hsa04024 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04923 Renin secretion - Homo sapiens (human) hsa04924 Morphine addiction - Homo sapiens (human) hsa05032,CHEMBL CHEMBL17127,P29274,Adenosine A2a receptor,1.0,ORTHOGONAL,NO,Nc1nc2c(cnn2CCc3ccccc3)c4nc(nn14)c5occc5,4,67,"InChI=1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)",UTLPKQYUXOEJIL-UHFFFAOYSA-N,"c(""Adenosine A2a receptor"", ""Adenosine A1 receptor"", ""Unchecked"", ""Adenosine receptors; A1 & A2"", ""Adenosine A3 receptor"", ""Adenosine receptors; A1 & A2a"", ""Adenosine receptors; A2a & A3"", ""Adenosine A2b receptor"", ""Adenosine A2 receptor"", ""Endoplasmic reticulum-associated amyloid beta-peptide-binding protein"", ""Lysine-specific demethylase 4D-like"", ""Ras-related protein Rab-9A"", ""Survival motor neuron protein"", ""Aldehyde dehydrogenase 1A1"", ""Arachidonate 15-lipoxygenase"", ""MAP kinase ERK2"", ""Niemann-Pick C1 protein"", ""15-hydroxyprostaglandin dehydrogenase [NAD+]"", ""Cellular tumor antigen p53"", ""ATPase family AAA domain-containing protein 5"", ""Dopamine D1 receptor"", ""Histone-lysine N-methyltransferase, H3 lysine-9 specific 3"", ""Chromobox protein homolog 1"", ""Ataxin-2"", ""HEK293"", ""Cerebroside-sulfatase"")",135,AA2AR,Signal Transduction R-HSA-162582 Signalling by NGF R-HSA-166520 Activation of TRKA receptors R-HSA-187015 NGF-independant TRKA activation R-HSA-187024 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 Adenosine P1 receptors R-HSA-417973 Nucleotide-like (purinergic) receptors R-HSA-418038 G alpha (s) signalling events R-HSA-418555 GPCR ligand binding R-HSA-500792,16339847 IDA GO:0005886 plasma membrane TAS GO:0005886 plasma membrane 21393508 IMP GO:0005887 integral component of plasma membrane 10051547 TAS GO:0016020 membrane,GO:0001973 adenosine receptor signaling pathway IEA GO:0006171 cAMP biosynthetic process 10899090 TAS GO:0006909 phagocytosis 8360491 TAS GO:0006915 apoptotic process 7818494 TAS GO:0006954 inflammatory response 8360491 TAS GO:0006968 cellular defense response 10051547 TAS GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway 10899090 TAS GO:0007267 cell-cell signaling 7818494 TAS GO:0007417 central nervous system development 10945659 TAS GO:0007596 blood coagulation 10899090 TAS GO:0007600 sensory perception 9262401 TAS GO:0008015 blood circulation 9262401 TAS GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway 21393508 IDA GO:0044267 cellular protein metabolic process TAS,GO:0001609 G-protein coupled adenosine receptor activity 21393508 21593763 IDA GO:0005515 protein binding 11571652 12189203 16027149 16339847 16481441 17689978 19632986 IPI GO:0019899 enzyme binding 16339847 IPI GO:0042802 identical protein binding 18675812 19013155 IPI,"hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) hsa05012 Parkinson,s disease - Homo sapiens (human) hsa05034 Alcoholism - Homo sapiens (human)",CHEMBL CHEMBL431770,P29274,Adenosine A2a receptor,1.0,PRIMARY,NO,CCN1C(=O)N(CC)c2nc(\C=C\c3ccc(OC)c(OC)c3)n(C)c2C1=O,5,45,"InChI=1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+",IQVRBWUUXZMOPW-PKNBQFBNSA-N,"c(""Adenosine A2a receptor"", ""Adenosine A1 receptor"", ""Adenosine receptors; A1 & A2a"", ""Unchecked"", ""Adenosine A2b receptor"", ""Adenosine A3 receptor"", ""Monoamine oxidase B"", ""Peroxisome proliferator-activated receptor delta"")",135,AA2AR,Signal Transduction R-HSA-162582 Signalling by NGF R-HSA-166520 Activation of TRKA receptors R-HSA-187015 NGF-independant TRKA activation R-HSA-187024 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 Adenosine P1 receptors R-HSA-417973 Nucleotide-like (purinergic) receptors R-HSA-418038 G alpha (s) signalling events R-HSA-418555 GPCR ligand binding R-HSA-500792,16339847 IDA GO:0005886 plasma membrane TAS GO:0005886 plasma membrane 21393508 IMP GO:0005887 integral component of plasma membrane 10051547 TAS GO:0016020 membrane,GO:0001973 adenosine receptor signaling pathway IEA GO:0006171 cAMP biosynthetic process 10899090 TAS GO:0006909 phagocytosis 8360491 TAS GO:0006915 apoptotic process 7818494 TAS GO:0006954 inflammatory response 8360491 TAS GO:0006968 cellular defense response 10051547 TAS GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway 10899090 TAS GO:0007267 cell-cell signaling 7818494 TAS GO:0007417 central nervous system development 10945659 TAS GO:0007596 blood coagulation 10899090 TAS GO:0007600 sensory perception 9262401 TAS GO:0008015 blood circulation 9262401 TAS GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway 21393508 IDA GO:0044267 cellular protein metabolic process TAS,GO:0001609 G-protein coupled adenosine receptor activity 21393508 21593763 IDA GO:0005515 protein binding 11571652 12189203 16027149 16339847 16481441 17689978 19632986 IPI GO:0019899 enzyme binding 16339847 IPI GO:0042802 identical protein binding 18675812 19013155 IPI,"hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) hsa05012 Parkinson,s disease - Homo sapiens (human) hsa05034 Alcoholism - Homo sapiens (human)",CHEMBL CHEMBL273807,P29275,Adenosine A2b receptor,1.0,ORTHOGONAL,NO,CCCN1C(=O)N(CCC)c2nc([nH]c2C1=O)c3ccc(OCC(=O)Nc4ccc(cc4)C#N)cc3,4,55,"InChI=1S/C26H26N6O4/c1-3-13-31-24-22(25(34)32(14-4-2)26(31)35)29-23(30-24)18-7-11-20(12-8-18)36-16-21(33)28-19-9-5-17(15-27)6-10-19/h5-12H,3-4,13-14,16H2,1-2H3,(H,28,33)(H,29,30)",AJBBEYXFRYFVNM-UHFFFAOYSA-N,"c(""Adenosine A1 receptor"", ""Adenosine A2a receptor"", ""Adenosine A2b receptor"", ""Adenosine A3 receptor"", ""Adenosine receptors; A1 & A2b"", ""Adenosine A2 receptor"", ""Adenosine receptors; A2b & A3"", ""Unchecked"", ""Prelamin-A/C"", ""Lysine-specific demethylase 4D-like"", ""Thyroid hormone receptor beta-1"", ""Peripheral myelin protein 22"", ""Bloom syndrome protein"", ""Neuropeptide S receptor"", ""ATPase family AAA domain-containing protein 5"", ""DNA polymerase iota"", ""Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1"" )",136,AA2BR,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signaling R-HSA-417973 Adenosine P1 receptors R-HSA-418038 Nucleotide-like (purinergic) receptors R-HSA-418555 G alpha (s) signalling events R-HSA-500792 GPCR ligand binding,intracellular GO:0005622 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 7558011 TAS,activation of MAPK activity GO:0000187 TAS 10101031 adenosine receptor signaling pathway GO:0001973 IEA positive regulation of chronic inflammatory response to non-antigenic stimulus GO:0002882 IEA cellular defense response GO:0006968 TAS 10101031 G-protein coupled receptor signaling pathway GO:0007186 TAS 7558011 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 IEA activation of adenylate cyclase activity GO:0007190 TAS 8022409 JNK cascade GO:0007254 TAS 10101031 excretion GO:0007588 TAS 7836474 positive regulation of vascular endothelial growth factor production GO:0010575 IEA positive regulation of guanylate cyclase activity GO:0031284 IEA cellular response to extracellular stimulus GO:0031668 IEA positive regulation of chemokine production GO:0032722 IEA positive regulation of interleukin-6 production GO:0032755 IEA positive regulation of mast cell degranulation GO:0043306 IEA cellular protein metabolic process GO:0044267 TAS relaxation of vascular smooth muscle GO:0060087 IEA,G-protein coupled adenosine receptor activity GO:0001609 IEA,Rap1 signaling pathway - Homo sapiens (human) hsa04015 Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Vascular smooth muscle contraction - Homo sapiens (human) hsa04270 Alcoholism - Homo sapiens (human) hsa05034,CHEMBL CHEMBL1490082,P29275,Adenosine A2b receptor,1.0,PRIMARY,NO,CC(C)OC(=O)C1=C(C)NC(=O)NC1c2occc2,6,13,"InChI=1S/C13H16N2O4/c1-7(2)19-12(16)10-8(3)14-13(17)15-11(10)9-5-4-6-18-9/h4-7,11H,1-3H3,(H2,14,15,17)",AMVBLUKTOOTWMN-UHFFFAOYSA-N,"c(""Menin/Histone-lysine N-methyltransferase MLL"", ""Lethal(3)malignant brain tumor-like protein 1"", ""DNA polymerase beta"", ""Eukaryotic translation initiation factor 4H"", ""Polyadenylate-binding protein 1"", ""Lysine-specific demethylase 4A"", ""Bromodomain adjacent to zinc finger domain protein 2B"", ""DNA polymerase iota"", ""DNA polymerase eta"", ""Adenosine A3 receptor"", ""Adenosine A2b receptor"", ""Adenosine A2a receptor"", ""Adenosine A1 receptor"")",136,AA2BR,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signaling R-HSA-417973 Adenosine P1 receptors R-HSA-418038 Nucleotide-like (purinergic) receptors R-HSA-418555 G alpha (s) signalling events R-HSA-500792 GPCR ligand binding,intracellular GO:0005622 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 7558011 TAS,activation of MAPK activity GO:0000187 TAS 10101031 adenosine receptor signaling pathway GO:0001973 IEA positive regulation of chronic inflammatory response to non-antigenic stimulus GO:0002882 IEA cellular defense response GO:0006968 TAS 10101031 G-protein coupled receptor signaling pathway GO:0007186 TAS 7558011 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 IEA activation of adenylate cyclase activity GO:0007190 TAS 8022409 JNK cascade GO:0007254 TAS 10101031 excretion GO:0007588 TAS 7836474 positive regulation of vascular endothelial growth factor production GO:0010575 IEA positive regulation of guanylate cyclase activity GO:0031284 IEA cellular response to extracellular stimulus GO:0031668 IEA positive regulation of chemokine production GO:0032722 IEA positive regulation of interleukin-6 production GO:0032755 IEA positive regulation of mast cell degranulation GO:0043306 IEA cellular protein metabolic process GO:0044267 TAS relaxation of vascular smooth muscle GO:0060087 IEA,G-protein coupled adenosine receptor activity GO:0001609 IEA,Rap1 signaling pathway - Homo sapiens (human) hsa04015 Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Vascular smooth muscle contraction - Homo sapiens (human) hsa04270 Alcoholism - Homo sapiens (human) hsa05034,CHEMBL CHEMBL1940400,O60218,Aldo-keto reductase family 1 member B10,1.0,PRIMARY,NO,COc1cc(O)ccc1\C=C\C(=O)OCCCc2cccc(O)c2,2,19,"InChI=1S/C19H20O5/c1-23-18-13-17(21)9-7-15(18)8-10-19(22)24-11-3-5-14-4-2-6-16(20)12-14/h2,4,6-10,12-13,20-21H,3,5,11H2,1H3/b10-8+",STRRKZLLUNQMGW-CSKARUKUSA-N,"c(""Aldose reductase"", ""Aldo-keto reductase family 1 member B10"", ""Unchecked"")",57016,AK1BA,Signal Transduction R-HSA-162582 Visual phototransduction R-HSA-2187338 Retinoid metabolism and transport R-HSA-975634,lysosome GO:0005764 IEA cytosol GO:0005829 TAS extracellular exosome 23376485 GO:0070062 IDA,TAS GO:0001523 retinoid metabolic process TAS 9565553 cellular aldehyde metabolic process GO:0006081 TAS 9565553 digestion GO:0007586 TAS 9565553 steroid metabolic process GO:0008202 IDA 21187079 farnesol catabolic process GO:0016488 IMP 20837989 daunorubicin metabolic process GO:0044597 IMP 20837989 doxorubicin metabolic process GO:0044598 IEA GO:0055114 oxidation-reduction process,IDA 21851338 retinal dehydrogenase activity GO:0001758 TAS 9565553 aldo-keto reductase (NADP) activity GO:0004033 IPI 18056116 21044950 protein binding GO:0005515 IDA 21187079 geranylgeranyl reductase activity GO:0045550 IDA 20837989 indanol dehydrogenase activity GO:0047718,Pentose and glucuronate interconversions - Homo sapiens (human) hsa00040 Fructose and mannose metabolism - Homo sapiens (human) hsa00051 Galactose metabolism - Homo sapiens (human) hsa00052 Glycerolipid metabolism - Homo sapiens (human) hsa00561,CHEMBL CHEMBL1443272,P42330,Aldo-keto-reductase family 1 member C3,1.0,ORTHOGONAL,NO,OC(=O)c1cccc(c1)S(=O)(=O)N2Cc3ccccc3C2,4,9,"InChI=1S/C15H13NO4S/c17-15(18)11-6-3-7-14(8-11)21(19,20)16-9-12-4-1-2-5-13(12)10-16/h1-8H,9-10H2,(H,17,18)",PMISBRGEZDFBQM-UHFFFAOYSA-N,"c(""Aldehyde dehydrogenase 1A1"", ""Chromobox protein homolog 1"", ""Unchecked"", ""Guanine nucleotide-binding protein G(s), subunit alpha"", ""Aldo-keto reductase family 1 member C1"", ""Aldo-keto-reductase family 1 member C3"", ""Aldo-keto reductase family 1 member C4"", ""Aldo-keto reductase family 1 member C2"")",8644,AK1C3,R-HSA-1430728 Metabolism R-HSA-162582 Signal Transduction R-HSA-192105 Synthesis of bile acids and bile salts R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-194068 Bile acid and bile salt metabolism R-HSA-2142753 Arachidonic acid metabolism R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2187338 Visual phototransduction R-HSA-5362517 Signaling by Retinoic Acid R-HSA-5365859 RA biosynthesis pathway R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-975634 Retinoid metabolism and transport,GO:0005622 intracellular IDA 18574251 GO:0005634 nucleus IDA 18574251 19336506 19942269 22170488 GO:0005737 cytoplasm IDA GO:0005829 cytosol TAS 23376485 23533145 GO:0070062 extracellular exosome IDA,"21787718 IDA GO:0000060 protein import into nucleus, translocation TAS GO:0001523 retinoid metabolic process 20036328 IEP GO:0006693 prostaglandin metabolic process 9792917 TAS GO:0006693 prostaglandin metabolic process 18508192 IDA GO:0007186 G-protein coupled receptor signaling pathway 19007764 IEP GO:0007584 response to nutrient 20036328 IEP GO:0008202 steroid metabolic process 18508192 20036328 IDA GO:0008284 positive regulation of cell proliferation 21851338 IMP GO:0008284 positive regulation of cell proliferation 19942269 IEP GO:0008584 male gonad development 18641923 IEP GO:0009267 cellular response to starvation 21787718 IDA GO:0010942 positive regulation of cell death 21187079 IDA GO:0016488 farnesol catabolic process TAS GO:0019371 cyclooxygenase pathway 22170488 IEP GO:0030216 keratinocyte differentiation 21787718 IDA GO:0034614 cellular response to reactive oxygen species 21232532 IDA GO:0042448 progesterone metabolic process IEA GO:0042572 retinol metabolic process 21851338 IDA GO:0042574 retinal metabolic process 18641923 IEP GO:0044259 multicellular organismal macromolecule metabolic process 20837989 IMP GO:0044597 daunorubicin metabolic process 20837989 IMP GO:0044598 doxorubicin metabolic process 21851338 IDA GO:0048385 regulation of retinoic acid receptor signaling pathway 18508192 IDA GO:0051897 positive regulation of protein kinase B signaling 16983398 19442656 21232532 IDA GO:0055114 oxidation-reduction process 9792917 TAS GO:0055114 oxidation-reduction process 16983398 IMP GO:0061370 testosterone biosynthetic process 16157291 NAS GO:0070293 renal absorption 21787718 IDA GO:0071276 cellular response to cadmium ion 22170488 IDA GO:0071277 cellular response to calcium ion 22170488 IDA GO:0071379 cellular response to prostaglandin stimulus 19336506 IDA GO:0071384 cellular response to corticosteroid stimulus 19487289 IDA GO:0071395 cellular response to jasmonic acid stimulus 18508192 IDA GO:0071799 cellular response to prostaglandin D stimulus 21851338 IDA GO:1900053 negative regulation of retinoic acid biosynthetic process 19336506 IMP GO:2000224 regulation of testosterone biosynthetic process 19442656 IDA GO:2000353 positive regulation of endothelial cell apoptotic process 19442656 IDA GO:2000379 positive regulation of reactive oxygen species metabolic process","21851338 IDA GO:0001758 retinal dehydrogenase activity 21232532 IDA GO:0004032 alditol:NADP+ 1-oxidoreductase activity 9792917 TAS GO:0004033 aldo-keto reductase (NADP) activity 21851338 IDA GO:0004745 retinol dehydrogenase activity 19442656 20837989 IDA GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 21851338 IDA GO:0018636 phenanthrene 9,10-monooxygenase activity 16983398 IDA GO:0035410 dihydrotestosterone 17-beta-dehydrogenase activity TAS GO:0036130 prostaglandin H2 endoperoxidase reductase activity TAS GO:0036131 prostaglandin D2 11-ketoreductase activity 21187079 IDA GO:0045550 geranylgeranyl reductase activity 19487289 IDA GO:0045703 ketoreductase activity IEA GO:0047017 prostaglandin-F synthase activity 22170488 IDA GO:0047020 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity 16983398 IDA GO:0047023 androsterone dehydrogenase activity IEA GO:0047035 testosterone dehydrogenase (NAD+) activity IEA GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity 21232532 IDA GO:0047086 ketosteroid monooxygenase activity IEA GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity IEA GO:0047718 indanol dehydrogenase activity 16983398 IDA GO:0047787 delta4-3-oxosteroid 5beta-reductase activity TAS GO:0052650 NADP-retinol dehydrogenase activity",hsa00140 Steroid hormone biosynthesis - Homo sapiens (human) hsa00590 Arachidonic acid metabolism - Homo sapiens (human) hsa04913 Ovarian steroidogenesis - Homo sapiens (human),CHEMBL CHEMBL2172076,P42330,Aldo-keto-reductase family 1 member C3,1.0,PRIMARY,NO,O=C1CCCN1c2ccc(cc2)S(=O)(=O)N3CCc4ccccc4C3,4,11,"InChI=1S/C19H20N2O3S/c22-19-6-3-12-21(19)17-7-9-18(10-8-17)25(23,24)20-13-11-15-4-1-2-5-16(15)14-20/h1-2,4-5,7-10H,3,6,11-14H2",QTXMWXSORYCFRR-UHFFFAOYSA-N,"c(""Aldo-keto-reductase family 1 member C3"", ""Aldo-keto reductase family 1 member C4"", ""Aldo-keto reductase family 1 member C2"", ""Aldo-keto reductase family 1 member C1"")",8644,AK1C3,R-HSA-1430728 Metabolism R-HSA-162582 Signal Transduction R-HSA-192105 Synthesis of bile acids and bile salts R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193775 Synthesis of bile acids and bile salts via 24-hydroxycholesterol R-HSA-193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-194068 Bile acid and bile salt metabolism R-HSA-2142753 Arachidonic acid metabolism R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2187338 Visual phototransduction R-HSA-5362517 Signaling by Retinoic Acid R-HSA-5365859 RA biosynthesis pathway R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-975634 Retinoid metabolism and transport,GO:0005622 intracellular IDA 18574251 GO:0005634 nucleus IDA 18574251 19336506 19942269 22170488 GO:0005737 cytoplasm IDA GO:0005829 cytosol TAS 23376485 23533145 GO:0070062 extracellular exosome IDA,"21787718 IDA GO:0000060 protein import into nucleus, translocation TAS GO:0001523 retinoid metabolic process 20036328 IEP GO:0006693 prostaglandin metabolic process 9792917 TAS GO:0006693 prostaglandin metabolic process 18508192 IDA GO:0007186 G-protein coupled receptor signaling pathway 19007764 IEP GO:0007584 response to nutrient 20036328 IEP GO:0008202 steroid metabolic process 18508192 20036328 IDA GO:0008284 positive regulation of cell proliferation 21851338 IMP GO:0008284 positive regulation of cell proliferation 19942269 IEP GO:0008584 male gonad development 18641923 IEP GO:0009267 cellular response to starvation 21787718 IDA GO:0010942 positive regulation of cell death 21187079 IDA GO:0016488 farnesol catabolic process TAS GO:0019371 cyclooxygenase pathway 22170488 IEP GO:0030216 keratinocyte differentiation 21787718 IDA GO:0034614 cellular response to reactive oxygen species 21232532 IDA GO:0042448 progesterone metabolic process IEA GO:0042572 retinol metabolic process 21851338 IDA GO:0042574 retinal metabolic process 18641923 IEP GO:0044259 multicellular organismal macromolecule metabolic process 20837989 IMP GO:0044597 daunorubicin metabolic process 20837989 IMP GO:0044598 doxorubicin metabolic process 21851338 IDA GO:0048385 regulation of retinoic acid receptor signaling pathway 18508192 IDA GO:0051897 positive regulation of protein kinase B signaling 16983398 19442656 21232532 IDA GO:0055114 oxidation-reduction process 9792917 TAS GO:0055114 oxidation-reduction process 16983398 IMP GO:0061370 testosterone biosynthetic process 16157291 NAS GO:0070293 renal absorption 21787718 IDA GO:0071276 cellular response to cadmium ion 22170488 IDA GO:0071277 cellular response to calcium ion 22170488 IDA GO:0071379 cellular response to prostaglandin stimulus 19336506 IDA GO:0071384 cellular response to corticosteroid stimulus 19487289 IDA GO:0071395 cellular response to jasmonic acid stimulus 18508192 IDA GO:0071799 cellular response to prostaglandin D stimulus 21851338 IDA GO:1900053 negative regulation of retinoic acid biosynthetic process 19336506 IMP GO:2000224 regulation of testosterone biosynthetic process 19442656 IDA GO:2000353 positive regulation of endothelial cell apoptotic process 19442656 IDA GO:2000379 positive regulation of reactive oxygen species metabolic process","21851338 IDA GO:0001758 retinal dehydrogenase activity 21232532 IDA GO:0004032 alditol:NADP+ 1-oxidoreductase activity 9792917 TAS GO:0004033 aldo-keto reductase (NADP) activity 21851338 IDA GO:0004745 retinol dehydrogenase activity 19442656 20837989 IDA GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor 21851338 IDA GO:0018636 phenanthrene 9,10-monooxygenase activity 16983398 IDA GO:0035410 dihydrotestosterone 17-beta-dehydrogenase activity TAS GO:0036130 prostaglandin H2 endoperoxidase reductase activity TAS GO:0036131 prostaglandin D2 11-ketoreductase activity 21187079 IDA GO:0045550 geranylgeranyl reductase activity 19487289 IDA GO:0045703 ketoreductase activity IEA GO:0047017 prostaglandin-F synthase activity 22170488 IDA GO:0047020 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity 16983398 IDA GO:0047023 androsterone dehydrogenase activity IEA GO:0047035 testosterone dehydrogenase (NAD+) activity IEA GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity 21232532 IDA GO:0047086 ketosteroid monooxygenase activity IEA GO:0047115 trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity IEA GO:0047718 indanol dehydrogenase activity 16983398 IDA GO:0047787 delta4-3-oxosteroid 5beta-reductase activity TAS GO:0052650 NADP-retinol dehydrogenase activity",hsa00140 Steroid hormone biosynthesis - Homo sapiens (human) hsa00590 Arachidonic acid metabolism - Homo sapiens (human) hsa04913 Ovarian steroidogenesis - Homo sapiens (human),CHEMBL CHEMBL3581716,Q10469,"Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase",1.0,PRIMARY,NO,CC(=O)Nc1cc(cc2CCN(CCc3ccccc3)c12)S(=O)(=O)Nc4ccc(F)cc4F,5,5,"InChI=1S/C24H23F2N3O3S/c1-16(30)27-23-15-20(33(31,32)28-22-8-7-19(25)14-21(22)26)13-18-10-12-29(24(18)23)11-9-17-5-3-2-4-6-17/h2-8,13-15,28H,9-12H2,1H3,(H,27,30)",XVSKYVJHKGLQMZ-UHFFFAOYSA-N,"c(""Acyl coenzyme A:cholesterol acyltransferase 1"", ""Diacylglycerol O-acyltransferase 2"", ""Diacylglycerol O-acyltransferase 1"", ""Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase"", ""Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"")",4247,MGAT2,R-HSA-392499 Metabolism of proteins R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-975576 N-glycan antennae elongation in the medial/trans-Golgi R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway,Golgi membrane TAS GO:0000139 Golgi apparatus IDA GO:0005794 Golgi stack IEA GO:0005795 membrane IDA 19946888 GO:0016020 integral component of membrane IEA GO:0016021,protein N-linked glycosylation GO:0006487 7635144 TAS oligosaccharide metabolic process GO:0009311 7635144 TAS oligosaccharide biosynthetic process GO:0009312 IEA protein N-linked glycosylation via asparagine GO:0018279 IEA,"alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity GO:0008455 TAS carbohydrate binding GO:0030246 IEA",N-Glycan biosynthesis - Homo sapiens (human) hsa00510,CHEMBL CHEMBL448620,P35348,Alpha-1a adrenergic receptor,1.0,PRIMARY,NO,COC(=O)C1=C(C)NC(=C(C1c2ccc(cc2)[N+](=O)[O-])C(=O)NCCCN3CCC(CC3)(c4ccccc4)c5ccccc5)C,7,55,"InChI=1S/C36H40N4O5/c1-25-31(33(32(26(2)38-25)35(42)45-3)27-15-17-30(18-16-27)40(43)44)34(41)37-21-10-22-39-23-19-36(20-24-39,28-11-6-4-7-12-28)29-13-8-5-9-14-29/h4-9,11-18,33,38H,10,19-24H2,1-3H3,(H,37,41)",FIIXCJGBCCCOQQ-UHFFFAOYSA-N,"c(""Alpha-1a adrenergic receptor"", ""Alpha-1b adrenergic receptor"", ""Alpha-1d adrenergic receptor"", ""Unchecked"", ""Adrenergic receptor alpha-1"", ""Alpha-2a adrenergic receptor"", ""Alpha-2b adrenergic receptor"", ""Alpha-2c adrenergic receptor"", ""Adrenergic receptors; alpha-1 A & B"", ""Tyrosyl-DNA phosphodiesterase 1"", ""Vitamin D receptor"", ""DNA polymerase kappa"")",148,ADA1A,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Amine ligand-binding receptors R-HSA-375280 GPCR downstream signaling R-HSA-388396 Adrenoceptors R-HSA-390696 G alpha (q) signalling events R-HSA-416476 G alpha (12/13) signalling events R-HSA-416482 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,GO:0005634 nucleus 22120526 IDA GO:0005829 cytosol IEA GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 8396931 TAS GO:0030018 Z disc IEA GO:0030315 T-tubule IEA GO:0031965 nuclear membrane 22120526 IDA,"negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure GO:0001985 IEA norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure GO:0001994 IBA positive regulation of heart rate by epinephrine-norepinephrine GO:0001996 IEA positive regulation of the force of heart contraction by epinephrine-norepinephrine GO:0001997 IEA positive regulation of systemic arterial blood pressure GO:0003084 IEA apoptotic process 10671514 GO:0006915 TAS smooth muscle contraction 8183249 GO:0006939 TAS signal transduction 8396931 GO:0007165 TAS G-protein coupled receptor signaling pathway 10860850 GO:0007186 TAS phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 IBA activation of phospholipase C activity GO:0007202 ISS positive regulation of cytosolic calcium ion concentration GO:0007204 IBA positive regulation of cytosolic calcium ion concentration GO:0007204 ISS cell-cell signaling 8396931 GO:0007267 TAS adult heart development GO:0007512 IEA aging GO:0007568 ISS negative regulation of cell proliferation 10860850 GO:0008285 TAS response to hormone GO:0009725 ISS cell growth GO:0016049 IEA positive regulation of synaptic transmission, GABAergic GO:0032230 ISS negative regulation of Rho protein signal transduction GO:0035024 ISS organ growth GO:0035265 IEA intracellular signal transduction 10671514 GO:0035556 TAS response to drug GO:0042493 ISS positive regulation of MAPK cascade 22120526 GO:0043410 IDA positive regulation of action potential GO:0045760 ISS positive regulation of vasoconstriction GO:0045907 IBA positive regulation of vasoconstriction GO:0045907 ISS positive regulation of smooth muscle contraction GO:0045987 IBA micturition GO:0060073 IEA calcium ion transport into cytosol GO:0060402 ISS positive regulation of cardiac muscle contraction GO:0060452 ISS positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 IBA positive regulation of protein kinase C signaling GO:0090037 ISS pilomotor reflex GO:0097195 IEA",alpha1-adrenergic receptor activity GO:0004937 ISS alpha1-adrenergic receptor activity 9490024 GO:0004937 NAS alpha1-adrenergic receptor activity 7737411 GO:0004937 TAS protein heterodimerization activity 22120526 GO:0046982 IDA,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04152 AMPK signaling pathway - Homo sapiens (human) hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) hsa04970 Salivary secretion - Homo sapiens (human),CHEMBL CHEMBL56438,P25100,Alpha-1d adrenergic receptor,1.0,PRIMARY,NO,Clc1ccc(Cl)c(c1)N2CCN(CCN3C(=O)CC4(CCCC4)CC3=O)CC2,4,11,"InChI=1S/C21H27Cl2N3O2/c22-16-3-4-17(23)18(13-16)25-10-7-24(8-11-25)9-12-26-19(27)14-21(15-20(26)28)5-1-2-6-21/h3-4,13H,1-2,5-12,14-15H2",LAZUXKZZDKCHKK-UHFFFAOYSA-N,"c(""Alpha-1b adrenergic receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Alpha-1a adrenergic receptor"", ""Alpha-1d adrenergic receptor"")",146,ADA1D,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375280 Amine ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-390696 Adrenoceptors R-HSA-416476 G alpha (q) signalling events R-HSA-416482 G alpha (12/13) signalling events R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 TAS 7746284,GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure IBA 10969806 GO:0006259 DNA metabolic process TAS 1656955 GO:0007186 G-protein coupled receptor signaling pathway TAS 10820200 GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA GO:0007204 positive regulation of cytosolic calcium ion concentration IBA 1656955 GO:0007267 cell-cell signaling TAS 10820200 GO:0007275 multicellular organism development TAS 10820200 GO:0008283 cell proliferation TAS 10860850 GO:0008284 positive regulation of cell proliferation TAS GO:0045907 positive regulation of vasoconstriction IBA GO:0045987 positive regulation of smooth muscle contraction IBA GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA,GO:0004937 alpha1-adrenergic receptor activity IEA 26460884 GO:0005515 protein binding IPI,Calcium signaling pathway - Homo sapiens (human) hsa04020 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04261 Vascular smooth muscle contraction - Homo sapiens (human) hsa04270 Salivary secretion - Homo sapiens (human) hsa04970,CHEMBL CHEMBL194173,P08913,Alpha-2a adrenergic receptor,1.0,PRIMARY,NO,CN(C)c1nc(NCC2CCN(CC2)S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)nc4ccccc14,3,3,"InChI=1S/C23H25BrF3N5O3S/c1-31(2)21-17-5-3-4-6-18(17)29-22(30-21)28-14-15-9-11-32(12-10-15)36(33,34)20-8-7-16(24)13-19(20)35-23(25,26)27/h3-8,13,15H,9-12,14H2,1-2H3,(H,28,29,30)",UHHJLMKELWKRFM-UHFFFAOYSA-N,"c(""Melanin-concentrating hormone receptor 1"", ""Neuropeptide Y receptor type 5"", ""Alpha-2a adrenergic receptor"")",150,ADA2A,"Hemostasis R-HSA-109582 Metabolism R-HSA-1430728 Signal Transduction R-HSA-162582 Integration of energy metabolism R-HSA-163685 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Amine ligand-binding receptors R-HSA-375280 GPCR downstream signaling R-HSA-388396 Adrenoceptors R-HSA-390696 Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 G alpha (i) signalling events R-HSA-418594 G alpha (z) signalling events R-HSA-418597 Regulation of insulin secretion R-HSA-422356 GPCR ligand binding R-HSA-500792 Platelet activation, signaling and aggregation R-HSA-76002 Platelet Aggregation (Plug Formation) R-HSA-76009",IDA 19477270 cytoplasm GO:0005737 TAS GO:0005886 plasma membrane IDA 2823383 10948191 10948198 integral component of plasma membrane GO:0005887 TAS 17655843 basolateral plasma membrane GO:0016323 IDA 10948191 receptor complex GO:0043235 IEA GO:0045202 synapse,positive regulation of cytokine production IDA 17655843 GO:0001819 acute inflammatory response IEA GO:0002526 DNA replication IEA GO:0006260 movement of cell or subcellular component TAS 9624180 GO:0006928 signal transduction TAS 2823383 10896916 GO:0007165 G-protein coupled receptor signaling pathway ISS 19965390 GO:0007186 negative regulation of adenylate cyclase activity ISS 1354394 GO:0007194 Ras protein signal transduction TAS 8226727 GO:0007265 Rho protein signal transduction TAS 9624180 GO:0007266 female pregnancy IEA GO:0007565 positive regulation of cell proliferation TAS 10896916 GO:0008284 negative regulation of norepinephrine secretion NAS 16531006 GO:0010700 negative regulation of norepinephrine secretion TAS 19477270 GO:0010700 regulation of vasoconstriction IEA GO:0019229 actin cytoskeleton organization TAS 9624180 GO:0030036 platelet activation IEA GO:0030168 positive regulation of cell migration IMP 17655843 GO:0030335 negative regulation of cAMP biosynthetic process IDA 16531006 GO:0030818 negative regulation of cAMP biosynthetic process ISS GO:0030818 activation of protein kinase activity IDA 15653687 GO:0032147 activation of protein kinase B activity IDA 17215105 GO:0032148 negative regulation of epinephrine secretion NAS 16531006 GO:0032811 cellular response to hormone stimulus IGI 10948198 GO:0032870 epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway IDA 17215105 17655843 GO:0035625 glucose homeostasis IMP 10952463 GO:0042593 positive regulation of potassium ion transport ISS 1354394 GO:0043268 positive regulation of MAP kinase activity IDA 19477270 GO:0043406 positive regulation of epidermal growth factor-activated receptor activity IDA 17655843 GO:0045741 positive regulation of vasodilation IEA GO:0045909 negative regulation of calcium ion-dependent exocytosis IC 10952463 GO:0045955 negative regulation of insulin secretion IMP 10952463 GO:0046676 regulation of insulin secretion TAS GO:0050796 intestinal absorption TAS 17655843 GO:0050892 thermoception IEA GO:0050955 negative regulation of lipid catabolic process IGI 10948198 GO:0050995 positive regulation of membrane protein ectodomain proteolysis IDA 17655843 GO:0051044 negative regulation of calcium ion transport ISS GO:0051926 negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP 19965390 GO:0061179 negative regulation of uterine smooth muscle contraction IEA GO:0070473 negative regulation of adrenergic receptor signaling pathway ISS GO:0071878 adenylate cyclase-activating adrenergic receptor signaling pathway IBA GO:0071880 adenylate cyclase-inhibiting adrenergic receptor signaling pathway IDA 10948191 GO:0071881 phospholipase C-activating adrenergic receptor signaling pathway IDA 10948191 GO:0071882 activation of MAPK activity by adrenergic receptor signaling pathway IDA 10948191 GO:0071883 positive regulation of wound healing IMP 17655843 GO:0090303 negative regulation of calcium ion transmembrane transporter activity ISS 1354394 GO:1901020,alpha2-adrenergic receptor activity IDA 10948191 GO:0004938 alpha2-adrenergic receptor activity ISS 1354394 GO:0004938 protein binding IPI 16531006 GO:0005515 protein kinase binding IPI 15653687 GO:0019901 alpha-1B adrenergic receptor binding ISS GO:0031692 alpha-2C adrenergic receptor binding IPI 16605244 GO:0031696 thioesterase binding IPI 19477270 GO:0031996 heterotrimeric G-protein binding IDA 10948191 GO:0032795 protein homodimerization activity IDA 16605244 GO:0042803 protein heterodimerization activity IPI 16605244 GO:0046982 protein heterodimerization activity ISS GO:0046982 epinephrine binding IDA 2823383 10948191 GO:0051379 norepinephrine binding IDA 2823383 GO:0051380,hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL106525,P18825,Alpha-2c adrenergic receptor,1.0,PRIMARY,NO,CN1CCN(CC1)c2ccc(Nc3c4ccccc4nc5ccccc35)cc2,4,85,"InChI=1S/C24H24N4/c1-27-14-16-28(17-15-27)19-12-10-18(11-13-19)25-24-20-6-2-4-8-22(20)26-23-9-5-3-7-21(23)24/h2-13H,14-17H2,1H3,(H,25,26)",QZKGUNQLVFEEBA-UHFFFAOYSA-N,"c(""Alpha-2a adrenergic receptor"", ""Alpha-2b adrenergic receptor"", ""Alpha-2c adrenergic receptor"", ""Unchecked"", ""ATP-dependent DNA helicase Q1"", ""Tyrosyl-DNA phosphodiesterase 1"", ""Bloom syndrome protein"", ""Alpha-galactosidase A"", ""DNA polymerase kappa"", ""Werner syndrome ATP-dependent helicase"", ""DNA-(apurinic or apyrimidinic site) lyase"", ""Flap endonuclease 1"", ""DNA polymerase iota"", ""MCF7"", ""COLO 205"", ""OVCAR-3"", ""CAKI-1"", ""RXF 393"", ""SN12C"", ""UO-31"", ""RPMI-8226"", ""UACC-62"", ""OVCAR-4"", ""TK-10"", ""MDA-MB-468"", ""HCT-116"", ""SR"", ""OVCAR-5"", ""HCT-15"", ""HOP-62"", ""OVCAR-8"", ""SF-268"", ""M14"", ""SK-OV-3"", ""Malme-3M"", ""NCI-H226"", ""KM12"", ""NCI-H23"", ""DU-145"", ""SF-539"", ""SW-620"", ""MDA-MB-435"", ""NCI-H322M"", ""SK-MEL-2"", ""SNB-19"", ""CCRF-CEM"", ""NCI-H460"", ""786-0"", ""SNB-75"", ""HL-60"", ""SK-MEL-28"", ""BT-549"", ""NCI-H522"", ""A498"", ""U251"", ""SK-MEL-5"", ""IGROV-1"", ""ACHN"", ""MOLT-4"", ""UACC-257"", ""Glucose transporter"")",152,ADA2C,"Hemostasis R-HSA-109582 Metabolism R-HSA-1430728 Signal Transduction R-HSA-162582 Integration of energy metabolism R-HSA-163685 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Amine ligand-binding receptors R-HSA-375280 GPCR downstream signaling R-HSA-388396 Adrenoceptors R-HSA-390696 Adrenaline signalling through Alpha-2 adrenergic receptor R-HSA-392023 Adrenaline,noradrenaline inhibits insulin secretion R-HSA-400042 G alpha (i) signalling events R-HSA-418594 G alpha (z) signalling events R-HSA-418597 Regulation of insulin secretion R-HSA-422356 GPCR ligand binding R-HSA-500792 Platelet activation, signaling and aggregation R-HSA-76002 Platelet Aggregation (Plug Formation) R-HSA-76009",16605244 IDA GO:0005737 cytoplasm 10196213 TAS GO:0005768 endosome TAS GO:0005886 plasma membrane 16605244 IDA GO:0005887 integral component of plasma membrane IEA GO:0043679 axon terminus,GO:0007186 G-protein coupled receptor signaling pathway 9371698 TAS GO:0007267 cell-cell signaling 9371698 TAS GO:0007565 female pregnancy IEA GO:0010700 negative regulation of norepinephrine secretion 16531006 NAS GO:0010700 negative regulation of norepinephrine secretion 19477270 TAS GO:0030168 platelet activation IEA GO:0032148 activation of protein kinase B activity 17215105 IDA GO:0032811 negative regulation of epinephrine secretion 16531006 NAS GO:0035625 epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway 17215105 IDA GO:0045666 positive regulation of neuron differentiation 17215105 IDA GO:0045907 positive regulation of vasoconstriction IEA GO:0050796 regulation of insulin secretion TAS GO:0051930 regulation of sensory perception of pain IEA GO:0070473 negative regulation of uterine smooth muscle contraction IEA GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA GO:0071883 activation of MAPK activity by adrenergic receptor signaling pathway 17215105 IDA,GO:0004938 alpha2-adrenergic receptor activity 17215105 IDA GO:0005515 protein binding 16531006 IPI GO:0031694 alpha-2A adrenergic receptor binding 16605244 IPI GO:0042803 protein homodimerization activity 16605244 IDA GO:0046982 protein heterodimerization activity 16605244 IPI GO:0051379 epinephrine binding 17215105 IDA,cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL2392121,Q16853,"Amine oxidase, copper containing",1.0,ORTHOGONAL,NO,Cl.CC(=O)Nc1nc(CCc2ccc(Cc3c[nH]c(N)n3)cc2)cs1,3,5,"InChI=1S/C17H19N5OS.ClH/c1-11(23)20-17-22-14(10-24-17)7-6-12-2-4-13(5-3-12)8-15-9-19-16(18)21-15;/h2-5,9-10H,6-8H2,1H3,(H3,18,19,21)(H,20,22,23);1H",XYQWAISRHSHNND-UHFFFAOYSA-N,"c(""Unchecked"", ""Monoamine oxidase A"", ""Monoamine oxidase B"", ""Amine oxidase, copper containing"")",8639,AOC3,,cytoplasm GO:0005737 23349812 IDA early endosome GO:0005769 23474851 IDA endoplasmic reticulum GO:0005783 23474851 IDA Golgi apparatus GO:0005794 23474851 IDA plasma membrane GO:0005886 9653080 IDA plasma membrane GO:0005886 TAS microvillus GO:0005902 23349812 IDA cell surface GO:0009986 9653080 23349812 IDA integral component of membrane GO:0016021 9653080 IDA,xenobiotic metabolic process GO:0006805 TAS inflammatory response GO:0006954 TAS 9653080 cell adhesion GO:0007155 IDA 9653080 amine metabolic process GO:0009308 IDA 9653080 response to antibiotic GO:0046677 IDA 19764817 oxidation-reduction process GO:0055114 IEA,copper ion binding GO:0005507 IDA 19764817 calcium ion binding GO:0005509 IDA 19764817 protein binding GO:0005515 IPI 23349812 primary amine oxidase activity GO:0008131 IDA 9653080 19764817 23349812 23474851 primary amine oxidase activity GO:0008131 TAS protein homodimerization activity GO:0042803 TAS 9653080 protein heterodimerization activity GO:0046982 IPI 23349812 quinone binding GO:0048038 IDA 9653080 tryptamine:oxygen oxidoreductase (deaminating) activity GO:0052593 IEA aminoacetone:oxygen oxidoreductase(deaminating) activity GO:0052594 IEA aliphatic-amine oxidase activity GO:0052595 IEA phenethylamine:oxygen oxidoreductase (deaminating) activity GO:0052596 IEA,"Glycine, serine and threonine metabolism - Homo sapiens (human) hsa00260 Tyrosine metabolism - Homo sapiens (human) hsa00350 Phenylalanine metabolism - Homo sapiens (human) hsa00360 beta-Alanine metabolism - Homo sapiens (human) hsa00410",CHEMBL CHEMBL3110303,Q16853,"Amine oxidase, copper containing",1.0,PRIMARY,NO,O=C1C=C(NC2CCCCC2)C(=NN1c3ccccc3)c4nc[nH]n4,3,6,"InChI=1S/C18H20N6O/c25-16-11-15(21-13-7-3-1-4-8-13)17(18-19-12-20-22-18)23-24(16)14-9-5-2-6-10-14/h2,5-6,9-13,21H,1,3-4,7-8H2,(H,19,20,22)",CRZJAUQQVQGZNE-UHFFFAOYSA-N,"c(""Amine oxidase, copper containing"", ""Unchecked"", ""Monoamine oxidase B"", ""Monoamine oxidase A"")",8639,AOC3,,cytoplasm GO:0005737 23349812 IDA early endosome GO:0005769 23474851 IDA endoplasmic reticulum GO:0005783 23474851 IDA Golgi apparatus GO:0005794 23474851 IDA plasma membrane GO:0005886 9653080 IDA plasma membrane GO:0005886 TAS microvillus GO:0005902 23349812 IDA cell surface GO:0009986 9653080 23349812 IDA integral component of membrane GO:0016021 9653080 IDA,xenobiotic metabolic process GO:0006805 TAS inflammatory response GO:0006954 TAS 9653080 cell adhesion GO:0007155 IDA 9653080 amine metabolic process GO:0009308 IDA 9653080 response to antibiotic GO:0046677 IDA 19764817 oxidation-reduction process GO:0055114 IEA,copper ion binding GO:0005507 IDA 19764817 calcium ion binding GO:0005509 IDA 19764817 protein binding GO:0005515 IPI 23349812 primary amine oxidase activity GO:0008131 IDA 9653080 19764817 23349812 23474851 primary amine oxidase activity GO:0008131 TAS protein homodimerization activity GO:0042803 TAS 9653080 protein heterodimerization activity GO:0046982 IPI 23349812 quinone binding GO:0048038 IDA 9653080 tryptamine:oxygen oxidoreductase (deaminating) activity GO:0052593 IEA aminoacetone:oxygen oxidoreductase(deaminating) activity GO:0052594 IEA aliphatic-amine oxidase activity GO:0052595 IEA phenethylamine:oxygen oxidoreductase (deaminating) activity GO:0052596 IEA,"Glycine, serine and threonine metabolism - Homo sapiens (human) hsa00260 Tyrosine metabolism - Homo sapiens (human) hsa00350 Phenylalanine metabolism - Homo sapiens (human) hsa00360 beta-Alanine metabolism - Homo sapiens (human) hsa00410",CHEMBL CHEMBL1077583,P15144,Aminopeptidase N,1.0,PRIMARY,NO,CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](CN)C(C)C)C(=O)N[C@H]2Cc3c(CN(CC(=O)N[C@@H](Cc4ccccc4)C(=O)O)C2=O)[nH]c5ccccc35,2,3,"InChI=1S/C44H55N7O8/c1-5-26(4)39(50-41(55)34(19-28-15-17-29(52)18-16-28)48-40(54)32(22-45)25(2)3)42(56)49-35-21-31-30-13-9-10-14-33(30)46-37(31)23-51(43(35)57)24-38(53)47-36(44(58)59)20-27-11-7-6-8-12-27/h6-18,25-26,32,34-36,39,46,52H,5,19-24,45H2,1-4H3,(H,47,53)(H,48,54)(H,49,56)(H,50,55)(H,58,59)/t26-,32-,34-,35-,36-,39-/m0/s1",KWZDTHCITDNKGD-LBVVFWMFSA-N,"c(""Aminopeptidase N"", ""Cystinyl aminopeptidase"", ""Unchecked"")",290,AMPN,Metabolism of Angiotensinogen to Angiotensins R-HSA-2022377 Peptide hormone metabolism R-HSA-2980736 Metabolism of proteins R-HSA-392499,extracellular space 16502470 25645918 GO:0005615 IDA lysosomal membrane 17897319 GO:0005765 IDA endoplasmic reticulum-Golgi intermediate compartment 15308636 GO:0005793 IDA cytosol GO:0005829 IEA integral component of plasma membrane 2564851 GO:0005887 TAS external side of plasma membrane GO:0009897 IEA vesicle membrane GO:0012506 IEA vesicle lumen GO:0031983 IEA extracellular exosome 15326289 19056867 19199708 21082674 23376485 23533145 GO:0070062 IDA,IEA GO:0001525 angiogenesis IEA GO:0006508 proteolysis IEA GO:0006725 cellular aromatic compound metabolic process IEA GO:0030154 cell differentiation IEA GO:0035814 negative regulation of renal sodium excretion IBA GO:0043171 peptide catabolic process IEA GO:0046718 viral entry into host cell,IEA GO:0001618 virus receptor activity TAS 10734069 aminopeptidase activity GO:0004177 TAS 1350662 receptor activity GO:0004872 TAS 2564851 metallopeptidase activity GO:0008237 IBA GO:0008270 zinc ion binding IBA GO:0042277 peptide binding IBA GO:0070006 metalloaminopeptidase activity,hsa00480 Glutathione metabolism - Homo sapiens (human) hsa04614 Renin-angiotensin system - Homo sapiens (human) hsa04640 Hematopoietic cell lineage - Homo sapiens (human),CHEMBL CHEMBL177577,O00519,Anandamide amidohydrolase,1.0,ORTHOGONAL,NO,O=C(CCCCCCc1ccccc1)c2oc(cn2)c3ccccn3,3,44,"InChI=1S/C21H22N2O2/c24-19(14-7-2-1-4-10-17-11-5-3-6-12-17)21-23-16-20(25-21)18-13-8-9-15-22-18/h3,5-6,8-9,11-13,15-16H,1-2,4,7,10,14H2",ILOIOIGZFHGSMS-UHFFFAOYSA-N,"c(""Anandamide amidohydrolase"", ""Unchecked"", ""Acyl coenzyme A:cholesterol acyltransferase"", ""Neutral cholesterol ester hydrolase 1"")",2166,FAAH1,,GO:0005789 endoplasmic reticulum membrane TAS GO:0005856 cytoskeleton IEA GO:0016021 integral component of membrane IEA GO:0031090 organelle membrane ISS,9122178 IDA GO:0009062 fatty acid catabolic process TAS GO:0019369 arachidonic acid metabolic process,"25416956 IPI GO:0005515 protein binding IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 9122178 IDA GO:0017064 fatty acid amide hydrolase activity TAS GO:0017064 fatty acid amide hydrolase activity IEA GO:0047372 acylglycerol lipase activity IEA GO:0103073 anandamide amidohydrolase activity",Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04723,CHEMBL CHEMBL184238,O00519,Anandamide amidohydrolase,1.0,PRIMARY,NO,NC(=O)c1cccc(c1)c2cccc(OC(=O)NC3CCCCC3)c2,4,46,"InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)",ROFVXGGUISEHAM-UHFFFAOYSA-N,"c(""Unchecked"", ""Anandamide amidohydrolase"", ""Transient receptor potential cation channel subfamily A member 1"", ""Histone-lysine N-methyltransferase, H3 lysine-9 specific 3"", ""ATPase family AAA domain-containing protein 5"", ""Chromobox protein homolog 1"", ""DNA polymerase iota"", ""Glucagon-like peptide 1 receptor"", ""Sn1-specific diacylglycerol lipase alpha"", ""Monoglyceride lipase"", ""Isocitrate dehydrogenase [NADP] cytoplasmic"")",2166,FAAH1,,GO:0005789 endoplasmic reticulum membrane TAS GO:0005856 cytoskeleton IEA GO:0016021 integral component of membrane IEA GO:0031090 organelle membrane ISS,9122178 IDA GO:0009062 fatty acid catabolic process TAS GO:0019369 arachidonic acid metabolic process,"25416956 IPI GO:0005515 protein binding IEA GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor 9122178 IDA GO:0017064 fatty acid amide hydrolase activity TAS GO:0017064 fatty acid amide hydrolase activity IEA GO:0047372 acylglycerol lipase activity IEA GO:0103073 anandamide amidohydrolase activity",Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04723,CHEMBL CHEMBL2323507,P10275,Androgen Receptor,1.0,ORTHOGONAL,NO,COc1ccc2c(c1)c(C)c(CCC(=O)O)n2C(=O)c3ccc(Cl)cc3,6,10,"InChI=1S/C20H18ClNO4/c1-12-16-11-15(26-2)7-8-18(16)22(17(12)9-10-19(23)24)20(25)13-3-5-14(21)6-4-13/h3-8,11H,9-10H2,1-2H3,(H,23,24)",NDOLIIHMVOZCMD-UHFFFAOYSA-N,"c(""Androgen Receptor"", ""Unchecked"", ""Cyclooxygenase-1"", ""Aldo-keto reductase family 1 member C4"", ""Aldo-keto reductase family 1 member C1"", ""Aldo-keto reductase family 1 member C2"", ""Aldo-keto-reductase family 1 member C3"")",367,ANDR,R-HSA-162582 Signal Transduction R-HSA-194315 Signaling by Rho GTPases R-HSA-195258 RHO GTPase Effectors R-HSA-212436 Generic Transcription Pathway R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-5625740 RHO GTPases activate PKNs R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-74160 Gene Expression,nuclear chromatin IDA 17277772 17505061 GO:0000790 nucleus IDA 15572661 19345326 GO:0005634 nucleoplasm TAS GO:0005654 cytoplasm IDA 15572661 17510388 GO:0005737 cytosol TAS GO:0005829 protein complex IDA 18468998 GO:0043234,"transcription, DNA-templated GO:0006351 15572661 IDA transcription initiation from RNA polymerase II promoter GO:0006367 TAS transport GO:0006810 10835690 TAS signal transduction GO:0007165 10835690 TAS cell-cell signaling GO:0007267 10835690 TAS sex differentiation GO:0007548 10075738 NAS cell proliferation GO:0008283 10075738 NAS positive regulation of cell proliferation GO:0008284 17277772 IDA negative regulation of cell proliferation GO:0008285 14521927 IMP positive regulation of gene expression GO:0010628 14521927 IMP cell growth GO:0016049 15572661 NAS androgen receptor signaling pathway GO:0030521 19886863 20048160 IDA intracellular receptor signaling pathway GO:0030522 17277772 IDA prostate gland development GO:0030850 10075738 NAS positive regulation of phosphorylation GO:0042327 21310825 IMP positive regulation of cell differentiation GO:0045597 14521927 IMP negative regulation of integrin biosynthetic process GO:0045720 21310825 IDA positive regulation of integrin biosynthetic process GO:0045726 21310825 IDA positive regulation of transcription, DNA-templated GO:0045893 11477070 12799378 IDA positive regulation of transcription from RNA polymerase II promoter GO:0045944 12799378 16728402 17505061 20048160 IDA positive regulation of transcription from RNA polymerase II promoter GO:0045944 19345326 IMP positive regulation of transcription from RNA polymerase III promoter GO:0045945 18487222 IDA positive regulation of NF-kappaB transcription factor activity GO:0051092 21310825 IMP protein oligomerization GO:0051259 18468998 IDA regulation of establishment of protein localization to plasma membrane GO:0090003 21310825 IDA negative regulation of extrinsic apoptotic signaling pathway GO:2001237 21310825 IDA","RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 16728402 IDA transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 16728402 IDA RNA polymerase II transcription factor binding GO:0001085 16120611 IPI DNA binding GO:0003677 10075738 NAS chromatin binding GO:0003682 21730289 IDA transcription factor activity, sequence-specific DNA binding GO:0003700 11477070 15572661 IDA RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 17277772 IDA androgen receptor activity GO:0004882 12799378 19886863 20048160 25091737 IDA androgen receptor activity GO:0004882 19345326 IMP androgen receptor activity GO:0004882 10075738 NAS androgen receptor activity GO:0004882 15572661 TAS receptor binding GO:0005102 11875111 IPI androgen binding GO:0005497 25091737 IDA androgen binding GO:0005497 10075738 NAS protein binding GO:0005515 10075738 10930412 10987273 11477070 12864730 14645241 15563469 15572661 16027218 16051670 16120611 16494870 16724108 16951154 17108144 17170703 17183365 17202144 17353003 17426252 17510388 17909037 18332867 18451096 18451177 18487222 18640093 19345326 19481544 19909775 20478527 20501646 20541699 21172304 21242980 21454491 21512132 21741601 21885566 22170608 22531786 23518348 23887938 24647988 24728074 25091737 25241761 IPI beta-catenin binding GO:0008013 12799378 IDA beta-catenin binding GO:0008013 12799378 IPI beta-catenin binding GO:0008013 16344550 TAS transcription factor binding GO:0008134 12799378 IPI zinc ion binding GO:0008270 IEA enzyme binding GO:0019899 17277772 17587566 IPI transcription regulatory region DNA binding GO:0044212 12799378 18487222 19886863 IDA protein dimerization activity GO:0046983 10075738 NAS ATPase binding GO:0051117 12058073 IDA",hsa04114 Oocyte meiosis - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human),CHEMBL CHEMBL2323490,P10275,Androgen Receptor,1.0,PRIMARY,NO,COc1ccc2c(c1)c(CC(=O)NS(=O)(=O)C(F)(F)F)cn2C(=O)c3ccc(Cl)cc3,6,10,"InChI=1S/C19H14ClF3N2O5S/c1-30-14-6-7-16-15(9-14)12(8-17(26)24-31(28,29)19(21,22)23)10-25(16)18(27)11-2-4-13(20)5-3-11/h2-7,9-10H,8H2,1H3,(H,24,26)",LOPOBSJDASSEKN-UHFFFAOYSA-N,"c(""Androgen Receptor"", ""Unchecked"", ""Cyclooxygenase-1"", ""Aldo-keto reductase family 1 member C4"", ""Aldo-keto reductase family 1 member C1"", ""Aldo-keto reductase family 1 member C2"", ""Aldo-keto-reductase family 1 member C3"")",367,ANDR,R-HSA-162582 Signal Transduction R-HSA-194315 Signaling by Rho GTPases R-HSA-195258 RHO GTPase Effectors R-HSA-212436 Generic Transcription Pathway R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-5625740 RHO GTPases activate PKNs R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-74160 Gene Expression,nuclear chromatin IDA 17277772 17505061 GO:0000790 nucleus IDA 15572661 19345326 GO:0005634 nucleoplasm TAS GO:0005654 cytoplasm IDA 15572661 17510388 GO:0005737 cytosol TAS GO:0005829 protein complex IDA 18468998 GO:0043234,"transcription, DNA-templated GO:0006351 15572661 IDA transcription initiation from RNA polymerase II promoter GO:0006367 TAS transport GO:0006810 10835690 TAS signal transduction GO:0007165 10835690 TAS cell-cell signaling GO:0007267 10835690 TAS sex differentiation GO:0007548 10075738 NAS cell proliferation GO:0008283 10075738 NAS positive regulation of cell proliferation GO:0008284 17277772 IDA negative regulation of cell proliferation GO:0008285 14521927 IMP positive regulation of gene expression GO:0010628 14521927 IMP cell growth GO:0016049 15572661 NAS androgen receptor signaling pathway GO:0030521 19886863 20048160 IDA intracellular receptor signaling pathway GO:0030522 17277772 IDA prostate gland development GO:0030850 10075738 NAS positive regulation of phosphorylation GO:0042327 21310825 IMP positive regulation of cell differentiation GO:0045597 14521927 IMP negative regulation of integrin biosynthetic process GO:0045720 21310825 IDA positive regulation of integrin biosynthetic process GO:0045726 21310825 IDA positive regulation of transcription, DNA-templated GO:0045893 11477070 12799378 IDA positive regulation of transcription from RNA polymerase II promoter GO:0045944 12799378 16728402 17505061 20048160 IDA positive regulation of transcription from RNA polymerase II promoter GO:0045944 19345326 IMP positive regulation of transcription from RNA polymerase III promoter GO:0045945 18487222 IDA positive regulation of NF-kappaB transcription factor activity GO:0051092 21310825 IMP protein oligomerization GO:0051259 18468998 IDA regulation of establishment of protein localization to plasma membrane GO:0090003 21310825 IDA negative regulation of extrinsic apoptotic signaling pathway GO:2001237 21310825 IDA","RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 16728402 IDA transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 16728402 IDA RNA polymerase II transcription factor binding GO:0001085 16120611 IPI DNA binding GO:0003677 10075738 NAS chromatin binding GO:0003682 21730289 IDA transcription factor activity, sequence-specific DNA binding GO:0003700 11477070 15572661 IDA RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 17277772 IDA androgen receptor activity GO:0004882 12799378 19886863 20048160 25091737 IDA androgen receptor activity GO:0004882 19345326 IMP androgen receptor activity GO:0004882 10075738 NAS androgen receptor activity GO:0004882 15572661 TAS receptor binding GO:0005102 11875111 IPI androgen binding GO:0005497 25091737 IDA androgen binding GO:0005497 10075738 NAS protein binding GO:0005515 10075738 10930412 10987273 11477070 12864730 14645241 15563469 15572661 16027218 16051670 16120611 16494870 16724108 16951154 17108144 17170703 17183365 17202144 17353003 17426252 17510388 17909037 18332867 18451096 18451177 18487222 18640093 19345326 19481544 19909775 20478527 20501646 20541699 21172304 21242980 21454491 21512132 21741601 21885566 22170608 22531786 23518348 23887938 24647988 24728074 25091737 25241761 IPI beta-catenin binding GO:0008013 12799378 IDA beta-catenin binding GO:0008013 12799378 IPI beta-catenin binding GO:0008013 16344550 TAS transcription factor binding GO:0008134 12799378 IPI zinc ion binding GO:0008270 IEA enzyme binding GO:0019899 17277772 17587566 IPI transcription regulatory region DNA binding GO:0044212 12799378 18487222 19886863 IDA protein dimerization activity GO:0046983 10075738 NAS ATPase binding GO:0051117 12058073 IDA",hsa04114 Oocyte meiosis - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human),CHEMBL CHEMBL409,P10275,Androgen Receptor,1.0,ORTHOGONAL,YES,CC(O)(CS(=O)(=O)c1ccc(F)cc1)C(=O)Nc2ccc(C#N)c(c2)C(F)(F)F,4,530,"InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)",LKJPYSCBVHEWIU-UHFFFAOYSA-N,"c(""Androgen Receptor"", ""Progesterone receptor"", ""Unchecked"", ""Glucocorticoid receptor"", ""Estrogen receptor alpha"", ""LNCaP"", ""PC-3"", ""ATPase family AAA domain-containing protein 5"", ""Histone-lysine N-methyltransferase, H3 lysine-9 specific 3"", ""Chromobox protein homolog 1"", ""Ubiquitin carboxyl-terminal hydrolase 1"", ""DU-145"", ""DSH1"", ""DV-90"", ""DU-4475"", ""EKVX"", ""ES4"", ""ES5"", ""ES3"", ""DoTc2-4510"", ""EB2"", ""EC-GI-10"", ""ECC4"", ""EFE-184"", ""EFM-19"", ""EFO-21"", ""A498"", ""A673"", ""C-33-A"", ""C-4-II"", ""COLO-792"", ""A704"", ""ABC-1"", ""C3A"", ""DK-MG"", ""ACHN"", ""COLO-829"", ""COR-L105"", ""AGS"", ""CAKI-1"", ""CAL-120"", ""COR-L88"", ""DMS-153"", ""DMS-273"", ""CAL-12T"", ""CP50-MEL-B"", ""CP66-MEL"", ""CWR22R"", ""ATN-1"", ""AU565"", ""CAL-33"", ""CAL-39"", ""CAL-51"", ""CTB-1"", ""23132-87"", ""639-V"", ""ASPC1"", ""CAL-54"", ""647-V"", ""BB30-HNC"", ""BB49-HNC"", ""CAL-85-1"", ""769-P"", ""786-0"", ""BB65-RCC"", ""CAMA-1"", ""Calu-1"", ""Calu-3"", ""8-MG-BA"", ""8305C"", ""BCPAP"", ""CAS-1"", ""CCF-STTG1"", ""Capan-2"", ""8505C"", ""BFTC-905"", ""A 172"", ""A204"", ""BHT-101"", ""BHY"", ""CHP-126"", ""A253 cell line"", ""CHP-212"", ""COLO 205"", ""A-375"", ""BOKU"", ""BT-20"", ""COLO-320-HSR"", ""COLO-668"", ""A4-Fuk"", ""COLO-678"", ""COLO-679"", ""COLO-680N"", ""D-542MG"", ""A-427"", ""A-431"", ""BV-173"", ""Becker"", ""BXPC-3"", ""COLO-741"", ""OE33"", ""OMC-1"", ""RPMI-8226"", ""SK-LU-1"", ""SW1990"", ""SW48"", ""SW-620"", ""GI-ME-N"", ""HLE"", ""KS-1"", ""KU-19-19"", ""LNCaP-Clone-FGC"", ""MFH-ino"", ""NB13"", ""NCI-H187"", ""NCI-H64"", ""NCI-H650"", ""RPMI 8402"", ""SK-MEL-2"", ""SK-MEL-24"", ""SK-MEL-28"", ""SW626"", ""SW684"", ""TT"", ""GMS-10"", ""KURAMOCHI"", ""LOX IMVI"", ""MHH-ES-1"", ""NB5"", ""NCI-H1993"", ""NCI-H2009"", ""NCI-H661"", ""OS-RC-2"", ""OVCAR-3"", ""SK-MEL3"", ""SK-MEL-30"", ""SW756"", ""SW780"", ""TYK-nu"", ""U-118-MG"", ""HO-1-N-1"", ""HOP-62"", ""JEG-3"", ""KYSE-140"", ""LS-1034"", ""LS-123"", ""MHH-PREB-1"", ""NB6"", ""NCI-H2030"", ""NCI-H2052"", ""NCI-H719"", ""OVCAR-5"", ""RT-4"", ""RVH-421"", ""RXF 393"", ""SK-MES-1"", ""SK-N-AS"", ""SW837"", ""SW872"", ""U2OS"", ""ES6"", ""ES7"", ""HOS"", ""HPAF-II"", ""KYSE-180"", ""LS-411N"", ""MIA PaCa-2"", ""NB69"", ""NCI-H2087"", ""NCI-H209"", ""NCI-H727"", ""NCI-H747"", ""OVCAR-8"", ""SW 954"", ""U-698-M"", ""ES8"", ""ESS-1"", ""KYSE-270"", ""KYSE-410"", ""LS-513"", ""MKN-28"", ""MKN-45"", ""MKN-7"", ""NCCIT"", ""NCI-H2122"", ""NCI-H2126"", ""PA-1"", ""S-117"", ""SAS"", ""SW 962"", ""UO-31"", ""U-251"", ""HT"", ""K5"", ""KYSE-510"", ""KYSE-520 cell line"", ""LU-139"", ""NCI-H1155"", ""NCI-H838"", ""PANC-03-27"", ""PANC-08-13"", ""SBC-1"", ""SBC-5"", ""SK-OV-3"", ""SK-PN-DW"", ""SW982"", ""SAOS-2"", ""SiHa"", ""UACC-257"", ""UACC-62"", ""EW-1"", ""EW-11"", ""HCC1395"", ""HCC1419"", ""HT1197"", ""KALS-1"", ""KYSE-70 cell line"", ""MMAC-SF"", ""NCI-H2228"", ""SNU1"", ""PC-14"", ""SCC-25"", ""SK-UT-1"", ""SKG-IIIa"", ""T47D"", ""UACC-893"", ""UMUC3"", ""UMC-11"", ""HCC1599"", ""HCC1806"", ""HT-144"", ""HT-29"", ""NCI-H1355"", ""SNU-16"", ""PF-382"", ""SCC-9"", ""SN12C"", ""SNB-75"", ""T84"", ""EW-16"", ""HCC1954"", ""HT-3"", ""HT55"", ""M059J"", ""M14"", ""NCI-H1417"", ""NCI-H1437"", ""NCI-H2342"", ""PSN1"", ""SCLC-21H"", ""SNG-M"", ""SNU-387"", ""SNU-423"", ""TCC-SUP"", ""TE-1"", ""VMRC-RCZ"", ""WM-115"", ""EW-24"", ""HCC2157"", ""HTC-C3"", ""HuTu80"", ""KGN"", ""LB1047-RCC"", ""MC-CAR"", ""MPP-89"", ""MRK-nu-1"", ""NCI-H1573"", ""NCI-H2347"", ""NCI-H2452"", ""NKM-1"", ""NMC-G1"", ""RCC10RGB"", ""SNU-449"", ""TE-10"", ""EW-3"", ""EW-7"", ""HCC38"", ""HuCCT-1"", ""KINGS-1"", ""LB2518-MEL"", ""MCF7"", ""NCI-H28"", ""NOMO-1"", ""NOS-1"", ""RCM-1"", ""RD"", ""SF-295"", ""SNU-C2B"", ""SR"", ""TE-11"", ""YKG-1"", ""YT"", ""FaDu"", ""FTC-133"", ""HCC70"", ""HuO-3N1"", ""KM12"", ""LB373-MEL-D"", ""LB771-HNC"", ""MDA-MB-175-VII"", ""MZ1-PC"", ""NCI-H1623"", ""NCI-H358"", ""NUGC-3"", ""RERF-LC-MS"", ""SH-4"", ""ST486"", ""SU-DHL-1"", ""SW1088"", ""TE-15"", ""TE-441-T"", ""TE-5"", ""no-10"", ""no-11"", ""G-361"", ""G-401"", ""HCE-T"", ""HCT-116"", ""HuP-T3"", ""IA-LM"", ""LB831-BLC"", ""MDA-MB-361"", ""MDA-MB-453"", ""NCI-H1650"", ""NCI-H1651"", ""NCI-H441"", ""RKO"", ""SW13"", ""SW1417"", ""GAK"", ""GAMG"", ""HCT-15"", ""IGROV-1"", ""KNS-81-FD"", ""LC-2-ad"", ""ME-180"", ""MZ7-mel"", ""MeWo"", ""NCI-H1693"", ""NCI-H510A"", ""OAW-42"", ""RMG-I"", ""SJSA-1"", ""SK-CO-1"", ""SW1573"", ""TE-8"", ""TE-9"", ""GB-1"", ""GCIY"", ""HEC-1"", ""IMR-5"", ""IPC-298"", ""LCLC-97TM1"", ""MEG-01"", ""MEL-HO"", ""MEL-JUSO"", ""NALM-6"", ""NCI-H1703"", ""NCI-H1734"", ""OCUB-M"", ""OE19"", ""RO82-W-1"", ""RPMI-2650"", ""SK-HEP1"", ""SW1710"", ""SW1783"", ""TGBC1TKB"", ""TGBC24TKB"", ""GDM-1"", ""HGC-27"", ""IST-MEL1"", ""IST-MES1"", ""LK-2"", ""LN-405"", ""MFE-280"", ""NB12"", ""NCI-H1792"", ""Tyrosine-protein kinase YES"", ""Cerebroside-sulfatase"")",367,ANDR,R-HSA-162582 Signal Transduction R-HSA-194315 Signaling by Rho GTPases R-HSA-195258 RHO GTPase Effectors R-HSA-212436 Generic Transcription Pathway R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-5625740 RHO GTPases activate PKNs R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-74160 Gene Expression,nuclear chromatin IDA 17277772 17505061 GO:0000790 nucleus IDA 15572661 19345326 GO:0005634 nucleoplasm TAS GO:0005654 cytoplasm IDA 15572661 17510388 GO:0005737 cytosol TAS GO:0005829 protein complex IDA 18468998 GO:0043234,"transcription, DNA-templated GO:0006351 15572661 IDA transcription initiation from RNA polymerase II promoter GO:0006367 TAS transport GO:0006810 10835690 TAS signal transduction GO:0007165 10835690 TAS cell-cell signaling GO:0007267 10835690 TAS sex differentiation GO:0007548 10075738 NAS cell proliferation GO:0008283 10075738 NAS positive regulation of cell proliferation GO:0008284 17277772 IDA negative regulation of cell proliferation GO:0008285 14521927 IMP positive regulation of gene expression GO:0010628 14521927 IMP cell growth GO:0016049 15572661 NAS androgen receptor signaling pathway GO:0030521 19886863 20048160 IDA intracellular receptor signaling pathway GO:0030522 17277772 IDA prostate gland development GO:0030850 10075738 NAS positive regulation of phosphorylation GO:0042327 21310825 IMP positive regulation of cell differentiation GO:0045597 14521927 IMP negative regulation of integrin biosynthetic process GO:0045720 21310825 IDA positive regulation of integrin biosynthetic process GO:0045726 21310825 IDA positive regulation of transcription, DNA-templated GO:0045893 11477070 12799378 IDA positive regulation of transcription from RNA polymerase II promoter GO:0045944 12799378 16728402 17505061 20048160 IDA positive regulation of transcription from RNA polymerase II promoter GO:0045944 19345326 IMP positive regulation of transcription from RNA polymerase III promoter GO:0045945 18487222 IDA positive regulation of NF-kappaB transcription factor activity GO:0051092 21310825 IMP protein oligomerization GO:0051259 18468998 IDA regulation of establishment of protein localization to plasma membrane GO:0090003 21310825 IDA negative regulation of extrinsic apoptotic signaling pathway GO:2001237 21310825 IDA","RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 16728402 IDA transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 16728402 IDA RNA polymerase II transcription factor binding GO:0001085 16120611 IPI DNA binding GO:0003677 10075738 NAS chromatin binding GO:0003682 21730289 IDA transcription factor activity, sequence-specific DNA binding GO:0003700 11477070 15572661 IDA RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 17277772 IDA androgen receptor activity GO:0004882 12799378 19886863 20048160 25091737 IDA androgen receptor activity GO:0004882 19345326 IMP androgen receptor activity GO:0004882 10075738 NAS androgen receptor activity GO:0004882 15572661 TAS receptor binding GO:0005102 11875111 IPI androgen binding GO:0005497 25091737 IDA androgen binding GO:0005497 10075738 NAS protein binding GO:0005515 10075738 10930412 10987273 11477070 12864730 14645241 15563469 15572661 16027218 16051670 16120611 16494870 16724108 16951154 17108144 17170703 17183365 17202144 17353003 17426252 17510388 17909037 18332867 18451096 18451177 18487222 18640093 19345326 19481544 19909775 20478527 20501646 20541699 21172304 21242980 21454491 21512132 21741601 21885566 22170608 22531786 23518348 23887938 24647988 24728074 25091737 25241761 IPI beta-catenin binding GO:0008013 12799378 IDA beta-catenin binding GO:0008013 12799378 IPI beta-catenin binding GO:0008013 16344550 TAS transcription factor binding GO:0008134 12799378 IPI zinc ion binding GO:0008270 IEA enzyme binding GO:0019899 17277772 17587566 IPI transcription regulatory region DNA binding GO:0044212 12799378 18487222 19886863 IDA protein dimerization activity GO:0046983 10075738 NAS ATPase binding GO:0051117 12058073 IDA",hsa04114 Oocyte meiosis - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human),CHEMBL CHEMBL436784,P10275,Androgen Receptor,1.0,PRIMARY,YES,FC(F)(F)CN(CC(F)(F)F)c1ccc2NC(=O)C=C(c2c1)C(F)(F)F,5,23,"InChI=1S/C14H9F9N2O/c15-12(16,17)5-25(6-13(18,19)20)7-1-2-10-8(3-7)9(14(21,22)23)4-11(26)24-10/h1-4H,5-6H2,(H,24,26)",ULBPQWIGZUGPHU-UHFFFAOYSA-N,"c(""Androgen Receptor"", ""Progesterone receptor"", ""Glucocorticoid receptor"", ""Mineralocorticoid receptor"", ""Estrogen receptor alpha"")",367,ANDR,R-HSA-162582 Signal Transduction R-HSA-194315 Signaling by Rho GTPases R-HSA-195258 RHO GTPase Effectors R-HSA-212436 Generic Transcription Pathway R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-5625740 RHO GTPases activate PKNs R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-74160 Gene Expression,nuclear chromatin IDA 17277772 17505061 GO:0000790 nucleus IDA 15572661 19345326 GO:0005634 nucleoplasm TAS GO:0005654 cytoplasm IDA 15572661 17510388 GO:0005737 cytosol TAS GO:0005829 protein complex IDA 18468998 GO:0043234,"transcription, DNA-templated GO:0006351 15572661 IDA transcription initiation from RNA polymerase II promoter GO:0006367 TAS transport GO:0006810 10835690 TAS signal transduction GO:0007165 10835690 TAS cell-cell signaling GO:0007267 10835690 TAS sex differentiation GO:0007548 10075738 NAS cell proliferation GO:0008283 10075738 NAS positive regulation of cell proliferation GO:0008284 17277772 IDA negative regulation of cell proliferation GO:0008285 14521927 IMP positive regulation of gene expression GO:0010628 14521927 IMP cell growth GO:0016049 15572661 NAS androgen receptor signaling pathway GO:0030521 19886863 20048160 IDA intracellular receptor signaling pathway GO:0030522 17277772 IDA prostate gland development GO:0030850 10075738 NAS positive regulation of phosphorylation GO:0042327 21310825 IMP positive regulation of cell differentiation GO:0045597 14521927 IMP negative regulation of integrin biosynthetic process GO:0045720 21310825 IDA positive regulation of integrin biosynthetic process GO:0045726 21310825 IDA positive regulation of transcription, DNA-templated GO:0045893 11477070 12799378 IDA positive regulation of transcription from RNA polymerase II promoter GO:0045944 12799378 16728402 17505061 20048160 IDA positive regulation of transcription from RNA polymerase II promoter GO:0045944 19345326 IMP positive regulation of transcription from RNA polymerase III promoter GO:0045945 18487222 IDA positive regulation of NF-kappaB transcription factor activity GO:0051092 21310825 IMP protein oligomerization GO:0051259 18468998 IDA regulation of establishment of protein localization to plasma membrane GO:0090003 21310825 IDA negative regulation of extrinsic apoptotic signaling pathway GO:2001237 21310825 IDA","RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 16728402 IDA transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 16728402 IDA RNA polymerase II transcription factor binding GO:0001085 16120611 IPI DNA binding GO:0003677 10075738 NAS chromatin binding GO:0003682 21730289 IDA transcription factor activity, sequence-specific DNA binding GO:0003700 11477070 15572661 IDA RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 17277772 IDA androgen receptor activity GO:0004882 12799378 19886863 20048160 25091737 IDA androgen receptor activity GO:0004882 19345326 IMP androgen receptor activity GO:0004882 10075738 NAS androgen receptor activity GO:0004882 15572661 TAS receptor binding GO:0005102 11875111 IPI androgen binding GO:0005497 25091737 IDA androgen binding GO:0005497 10075738 NAS protein binding GO:0005515 10075738 10930412 10987273 11477070 12864730 14645241 15563469 15572661 16027218 16051670 16120611 16494870 16724108 16951154 17108144 17170703 17183365 17202144 17353003 17426252 17510388 17909037 18332867 18451096 18451177 18487222 18640093 19345326 19481544 19909775 20478527 20501646 20541699 21172304 21242980 21454491 21512132 21741601 21885566 22170608 22531786 23518348 23887938 24647988 24728074 25091737 25241761 IPI beta-catenin binding GO:0008013 12799378 IDA beta-catenin binding GO:0008013 12799378 IPI beta-catenin binding GO:0008013 16344550 TAS transcription factor binding GO:0008134 12799378 IPI zinc ion binding GO:0008270 IEA enzyme binding GO:0019899 17277772 17587566 IPI transcription regulatory region DNA binding GO:0044212 12799378 18487222 19886863 IDA protein dimerization activity GO:0046983 10075738 NAS ATPase binding GO:0051117 12058073 IDA",hsa04114 Oocyte meiosis - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human),CHEMBL CHEMBL189568,P50052,Angiotensin II type 2 (AT-2) receptor,1.0,PRIMARY,NO,CCCCOC(=O)NS(=O)(=O)c1sc(CC(C)C)cc1c2ccc(Cn3ccnc3)cc2,2,12,"InChI=1S/C23H29N3O4S2/c1-4-5-12-30-23(27)25-32(28,29)22-21(14-20(31-22)13-17(2)3)19-8-6-18(7-9-19)15-26-11-10-24-16-26/h6-11,14,16-17H,4-5,12-13,15H2,1-3H3,(H,25,27)",XTEOJPUYZWEXFI-UHFFFAOYSA-N,"c(""Angiotensin II type 2 (AT-2) receptor"", ""Unchecked"", ""Type-1 angiotensin II receptor"")",186,AGTR2,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,GO:0005576 extracellular region IEA GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 10406457 IC GO:0048471 perinuclear region of cytoplasm IEA,"blood vessel remodeling 17159080 GO:0001974 TAS regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0001991 ISS renin-angiotensin regulation of aldosterone production GO:0002018 IEA vasodilation by angiotensin involved in regulation of systemic arterial blood pressure GO:0002033 IEA brain renin-angiotensin system GO:0002035 IEA cellular sodium ion homeostasis GO:0006883 IEA inflammatory response GO:0006954 IEA cell surface receptor signaling pathway 10406457 GO:0007166 IDA G-protein coupled receptor signaling pathway 10406457 GO:0007186 IC G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger 17000928 GO:0007199 ISS nitric oxide mediated signal transduction 17000928 GO:0007263 IC nitric oxide mediated signal transduction 17159080 GO:0007263 TAS brain development 12089445 GO:0007420 NAS regulation of blood pressure 7477266 GO:0008217 TAS positive regulation of cell proliferation GO:0008284 IEA negative regulation of heart rate GO:0010459 ISS negative regulation of norepinephrine secretion GO:0010700 IEA cerebellar cortex development GO:0021695 IEA negative regulation of cell growth 17159080 GO:0030308 TAS negative regulation of icosanoid secretion GO:0032304 IEA positive regulation of phosphoprotein phosphatase activity 10406457 GO:0032516 IDA intracellular signal transduction 17000928 GO:0035556 ISS regulation of metanephros size GO:0035566 IEA exploration behavior GO:0035640 IEA positive regulation of renal sodium excretion GO:0035815 IEA aldosterone secretion GO:0035932 IEA angiotensin-activated signaling pathway GO:0038166 IEA dopamine biosynthetic process GO:0042416 IEA regulation of transcription factor import into nucleus GO:0042990 IEA negative regulation of blood vessel endothelial cell migration 15710780 GO:0043537 NAS positive regulation of nitric oxide biosynthetic process 17000928 GO:0045429 IC positive regulation of transcription, DNA-templated GO:0045893 IEA positive regulation of vasodilation 15117835 17159079 GO:0045909 IDA negative regulation of fibroblast proliferation GO:0048147 IEA positive regulation of cytokine secretion GO:0050715 IEA positive regulation of nitric-oxide synthase activity 17000928 GO:0051000 ISS negative regulation of neurotrophin TRK receptor signaling pathway 10406457 GO:0051387 IMP cell growth involved in cardiac muscle cell development GO:0061049 IEA cellular response to dexamethasone stimulus GO:0071549 IEA positive regulation of metanephric glomerulus development GO:0072300 IEA positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 IEA extracellular negative regulation of signal transduction GO:1900116 IEA positive regulation of extrinsic apoptotic signaling pathway 10406457 GO:2001238 IMP",angiotensin type II receptor activity 10406457 GO:0004945 IPI protein binding 10406457 18344519 23597562 GO:0005515 IPI transcription factor binding GO:0008134 IEA peptide hormone binding GO:0017046 IEA receptor antagonist activity 17159079 GO:0048019 TAS,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04614 Renin-angiotensin system - Homo sapiens (human),CHEMBL CHEMBL3234446,Q9ULZ1,Apelin,1.0,PRIMARY,NO,CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@@H](N)CCCCN)C(=O)N5CCC[C@H]5C(=O)N[C@@H](Cc6ccccc6)C(=O)O,2,3,"InChI=1S/C96H156N34O20S/c1-55(2)47-67(83(140)127-71(53-131)86(143)125-69(50-58-51-109-54-115-58)85(142)116-60(26-11-13-38-98)78(135)114-52-76(133)128-43-18-31-72(128)87(144)122-66(36-46-151-3)91(148)130-45-20-33-74(130)89(146)126-70(92(149)150)49-57-23-8-5-9-24-57)124-81(138)63(29-16-41-112-95(105)106)120-88(145)73-32-19-44-129(73)90(147)65(30-17-42-113-96(107)108)121-82(139)64(34-35-75(100)132)119-80(137)61(27-14-39-110-93(101)102)117-79(136)62(28-15-40-111-94(103)104)118-84(141)68(48-56-21-6-4-7-22-56)123-77(134)59(99)25-10-12-37-97/h4-9,21-24,51,54-55,59-74,131H,10-20,25-50,52-53,97-99H2,1-3H3,(H2,100,132)(H,109,115)(H,114,135)(H,116,142)(H,117,136)(H,118,141)(H,119,137)(H,120,145)(H,121,139)(H,122,144)(H,123,134)(H,124,138)(H,125,143)(H,126,146)(H,127,140)(H,149,150)(H4,101,102,110)(H4,103,104,111)(H4,105,106,112)(H4,107,108,113)/t59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-/m0/s1",SVWSKJCJNAIKNH-MJZUAXFLSA-N,"c(""Type-1 angiotensin II receptor"", ""Unchecked"", ""Apelin"")",8862,APEL,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,extracellular region GO:0005576 TAS extracellular space GO:0005615 IBA perinuclear region of cytoplasm GO:0048471 IEA,GO:0002026 regulation of the force of heart contraction IEA 10525157 GO:0006955 immune response TAS GO:0007165 signal transduction IEA 10525157 GO:0007595 lactation TAS GO:0008284 positive regulation of cell proliferation IEA GO:0031652 positive regulation of heat generation IEA GO:0042327 positive regulation of phosphorylation IEA GO:0042756 drinking behavior IEA GO:0043576 regulation of respiratory gaseous exchange IEA GO:0045776 negative regulation of blood pressure IEA GO:0045906 negative regulation of vasoconstriction IEA GO:0045909 positive regulation of vasodilation IEA GO:0051461 positive regulation of corticotropin secretion IEA GO:0051466 positive regulation of corticotropin-releasing hormone secretion IEA,GO:0001664 G-protein coupled receptor binding IBA 9792798 10525157 GO:0005102 receptor binding TAS GO:0005179 hormone activity IEA GO:0031704 apelin receptor binding IEA,,CHEMBL CHEMBL443684,Q07817,Apoptosis regulator Bcl-X,1.0,PRIMARY,NO,CC1(C)CCC(=C(CN2CCN(CC2)c3ccc(cc3)C(=O)NS(=O)(=O)c4ccc(N[C@H](CCN5CCOCC5)CSc6ccccc6)c(c4)S(=O)(=O)C(F)(F)F)C1)c7ccc(Cl)cc7,4,507,"InChI=1S/C47H55ClF3N5O6S3/c1-46(2)20-18-42(34-8-12-37(48)13-9-34)36(31-46)32-55-22-24-56(25-23-55)39-14-10-35(11-15-39)45(57)53-65(60,61)41-16-17-43(44(30-41)64(58,59)47(49,50)51)52-38(19-21-54-26-28-62-29-27-54)33-63-40-6-4-3-5-7-40/h3-17,30,38,52H,18-29,31-33H2,1-2H3,(H,53,57)/t38-/m1/s1",JLYAXFNOILIKPP-KXQOOQHDSA-N,"c(""Bcl2-antagonist of cell death (BAD)"", ""Unchecked"", ""Apoptosis regulator Bcl-2"", ""Apoptosis regulator Bcl-X"", ""NCI-H1963"", ""NCI-H889"", ""DNA polymerase iota"", ""Flap endonuclease 1"", ""DNA polymerase kappa"", ""HepG2"", ""Mothers against decapentaplegic homolog 3"", ""78 kDa glucose-regulated protein"", ""NCI-H1417"", ""NCI-H187"", ""DOK"", ""DSH1"", ""DU-4475"", ""Daoy"", ""DU-145"", ""EKVX"", ""EM-2"", ""EPLC-272H"", ""ES4"", ""ES5"", ""ES1"", ""ES3"", ""DoTc2-4510"", ""ECC10"", ""EFM-19"", ""EFO-21"", ""EFO-27"", ""EGI-1"", ""A673"", ""BXPC-3"", ""C-33-A"", ""COLO-741"", ""COLO-792"", ""DEL"", ""DJM-1"", ""A704"", ""ABC-1"", ""C2BBe1"", ""C32"", ""COLO-800"", ""COLO-824"", ""DK-MG"", ""DMS-114"", ""ACHN"", ""ACN"", ""C8166"", ""COLO-829"", ""COR-L105"", ""DOHH-2"", ""AGS"", ""ALL-PO"", ""CAL-120"", ""COR-L23"", ""COR-L88"", ""DMS-273"", ""AM-38"", ""AN3-CA"", ""CAL-12T"", ""CAL-27"", ""CP50-MEL-B"", ""ATN-1"", ""CAL-33"", ""CAL-39"", ""CTB-1"", ""5637"", ""ASPC1"", ""BALL-1"", ""CAL-54"", ""CTV-1"", ""CW-2"", ""639-V"", ""647-V"", ""BB30-HNC"", ""BB49-HNC"", ""CAL-85-1"", ""Ca-Ski"", ""Ca9-22"", ""697"", ""769-P"", ""BB65-RCC"", ""CAMA-1"", ""CAPAN-1"", ""CaR-1"", ""Calu-3"", ""8305C"", ""BCPAP"", ""CCRF-CEM"", ""Calu-6"", ""Capan-2"", ""8505C"", ""A101D"", ""BE-13"", ""BEN"", ""BFTC-905"", ""CFPAC-1"", ""ChaGo-K-1"", ""D-247MG"", ""A204"", ""BHT-101"", ""CGTH-W-1"", ""CHP-134"", ""A2058"", ""A2780"", ""BHY"", ""CHP-212"", ""D283 Med"", ""A3-KAW"", ""A-375"", ""BPH-1"", ""BT-20"", ""COLO-320-HSR"", ""COLO-668"", ""D-502MG"", ""A388"", ""BT-549"", ""COLO-678"", ""D-566MG"", ""A-427"", ""A-431"", ""BV-173"", ""Becker"", ""COLO-680N"", ""COLO-684"", ""DB"", ""NCI-H1838"", ""NCI-H526"", ""NCI-H596"", ""OE19"", ""OE33"", ""RPMI-7951"", ""RPMI-8226"", ""SK-LU-1"", ""SK-MEL-1"", ""SW1990"", ""SW48"", ""TGBC24TKB"", ""TGW"", ""GI-1"", ""HH"", ""HL-60"", ""IST-SL1"", ""KS-1"", ""KU-19-19"", ""MFM-223"", ""NB12"", ""NB13"", ""NCI-H630"", ""OMC-1"", ""RPMI-8866"", ""SK-MEL-2"", ""SK-MEL-24"", ""SW-620"", ""SW626"", ""TI-73"", ""TK-10"", ""GMS-10"", ""HLE"", ""HMV-2 cell line"", ""HN"", ""J-RT3-T3-5"", ""J82"", ""KU812 cell line"", ""LOX IMVI"", ""MHH-ES-1"", ""NB14"", ""NB17"", ""NCI-H2029"", ""NCI-H661"", ""NCI-H69"", ""OS-RC-2"", ""RS4-11"", ""RT-112"", ""SK-MEL-28"", ""SK-MEL3"", ""SK-MEL-30"", ""SW756"", ""SW780"", ""TYK-nu"", ""U-118-MG"", ""GOTO"", ""GP5d"", ""HO-1-N-1"", ""JEG-3"", ""KURAMOCHI"", ""KY821"", ""MHH-NB-11"", ""NB5"", ""NB6"", ""NCI-H2030"", ""NCI-H2052"", ""OVCAR-3"", ""OVCAR-4"", ""RVH-421"", ""RXF 393"", ""SW837"", ""SW872"", ""U2OS"", ""ES6"", ""GT3TKB"", ""H-EMC-SS"", ""HOP-92"", ""HOS"", ""JVM-3"", ""KYSE-150 cell line"", ""KYSE-180"", ""LS-123"", ""MHH-PREB-1"", ""MKN-1"", ""NB69"", ""NBsusSR"", ""NCI-H2087"", ""NCI-H209"", ""NCI-H720"", ""NCI-H727"", ""OVCAR-5"", ""OVCAR-8"", ""P12-Ichikawa"", ""Ramos-2G6-4C10"", ""SK-N-AS"", ""SK-N-DZ"", ""SW900"", ""SW948"", ""ES7"", ""ES8"", ""H9"", ""HPAF-II"", ""HSC-2"", ""HSC-3"", ""K562"", ""KYSE-270"", ""KYSE-410"", ""LU-134-A"", ""LU-135"", ""MKN-28"", ""NCI-H1048"", ""NCI-H2122"", ""NCI-H2126"", ""NCI-H810"", ""P30-OHK"", ""SAS"", ""SK-N-FI"", ""SK-NEP-1"", ""SW 954"", ""SW 962"", ""UO-31"", ""ESS-1"", ""ETK-1"", ""HAL-01"", ""K5"", ""KYSE-450"", ""KYSE-510"", ""KYSE-520 cell line"", ""LU-139"", ""MKN-7"", ""ML-2"", ""NCI-H1092"", ""NCI-H1155"", ""NCI-H2170"", ""NCI-H82"", ""PA-1"", ""PANC-03-27"", ""PANC-08-13"", ""SBC-1"", ""SK-PN-DW"", ""SAOS-2"", ""UACC-257"", ""EW-1"", ""HCC1187"", ""HCC1395"", ""HCC1419"", ""HT-1080"", ""HT1197"", ""KALS-1"", ""KARPAS-299"", ""KYSE-70 cell line"", ""L-363"", ""Lu-65"", ""MLMA"", ""MMAC-SF"", ""NCI-H1304"", ""NCI-N87"", ""SNU1"", ""Panc1005"", ""SCC-15"", ""SCC-25"", ""SK-UT-1"", ""SKG-IIIa"", ""SiHa"", ""T-24"", ""UACC-893"", ""UMUC3"", ""EW-11"", ""EW-13"", ""HCC1569"", ""HT-1376"", ""HT-144"", ""KARPAS-45"", ""L-428"", ""LXF-289 cell line"", ""LoVo"", ""MN-60"", ""MOLT-13"", ""NCI-H1355"", ""NCI-H2228"", ""NCI-H2291"", ""SNU-5"", ""PFSK-1"", ""SCC-4"", ""SCC-9"", ""SN12C"", ""T84"", ""T98G"", ""UMC-11"", ""VA-ES-BJ"", ""EW-16"", ""HCC1806"", ""HCC1937"", ""HCC1954"", ""HT-3"", ""KE-37"", ""LAMA-84"", ""LAN-6"", ""M059J"", ""MOLT-16"", ""MOLT-4"", ""NCI-H23"", ""NCI-H2342"", ""NEC8"", ""NH-12"", ""PSN1"", ""SCH"", ""SNU-387"", ""SNU-423"", ""TCC-SUP"", ""VM-CUB-1"", ""VMRC-RCZ"", ""WM-115"", ""EW-18"", ""EW-22"", ""HCC2157"", ""HCC2218"", ""HTC-C3"", ""KG-1"", ""LB1047-RCC"", ""MC-IXC"", ""MC116"", ""MPP-89"", ""NCI-H1563"", ""NCI-H2347"", ""NCI-H2405"", ""NKM-1"", ""NMC-G1"", ""QIMR-WIL"", ""RCC10RGB"", ""SF-126"", ""SNU-449"", ""YAPC"", ""YH-13"", ""EW-3"", ""HCC 2998"", ""HCC38"", ""KINGS-1"", ""KLE"", ""LB2241-RCC"", ""LB2518-MEL"", ""MCF7"", ""MS-1"", ""NCI-H1581"", ""NCI-H2452"", ""NCI-H292"", ""NOMO-1"", ""RCM-1"", ""RD"", ""SF-295"", ""SNU-C2B"", ""TE-11"", ""TE-12"", ""YKG-1"", ""EOL1"", ""FTC-133"", ""HCC70"", ""Huh-7"", ""HuO-3N1"", ""HuO9"", ""KM-H2"", ""KM12"", ""MDA-MB-157"", ""MDA-MB-175-VII"", ""MV4-11"", ""NCI-H1623"", ""NCI-H1648"", ""NOS-1"", ""NTERA-2-cl-D1"", ""RH-1"", ""SH-4"", ""G-402"", ""HCE-T"", ""HuP-T3"", ""HuP-T4"", ""LB831-BLC"", ""MDA-MB-361"", ""MDA-MB-415"", ""NCI-H1650"", ""NCI-H1651"", ""NCI-H358"", ""NCI-H441"", ""NUGC-3"", ""NY"", ""OAW-28"", ""RH-18"", ""SHP77"", ""SW 1116"", ""SW13"", ""TE-5"", ""TE-6"", ""no-11"", ""GAMG"", ""HD-MY-Z"", ""IA-LM"", ""IGR-1"", ""KNS-42"", ""KNS-62"", ""LB996-RCC"", ""ME-180"", ""MeWo"", ""NCI-H1666"", ""NCI-H1693"", ""NCI-H446"", ""OAW-42"", ""OC-314"", ""RMG-I"", ""SJSA-1"", ""SW1417"", ""SW1463"", ""SW1573"", ""TE-8"", ""TE-9"", ""GB-1"", ""HDLM-2"", ""HEC-1"", ""KNS-81-FD"", ""KOSC-2"", ""KP-4"", ""LC-2-ad"", ""LCLC-103H cell line"", ""MEG-01"", ""MEL-HO"", ""Mo"", ""NCI-H522"", ""OCI-AML2"", ""OCUB-M"", ""RO82-W-1"", ""RPMI-2650"", ""SW1710"", ""SW1783"", ""TGBC11TKB"", ""TGBC1TKB"", ""GCIY"", ""GCT"", ""HEL"", ""HGC-27"", ""IST-MEL1"", ""KP-N-YN"", ""KP-N-YS"", ""LK-2"", ""MFE-280"", ""NB10"", ""NCI-H1770"", ""NCI-H1792"", ""Induced myeloid leukemia cell differentiation protein Mcl-1"", ""Tyrosine-protein kinase YES"", ""DNA polymerase eta"")",598,B2CL1,"Apoptosis R-HSA-109581 Intrinsic Pathway for Apoptosis R-HSA-109606 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members R-HSA-111453 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 Programmed Cell Death R-HSA-5357801 Inflammasomes R-HSA-622312 The NLRP1 inflammasome R-HSA-844455",IDA 20673843 cytoplasm GO:0005737 IDA 12011449 mitochondrion GO:0005739 NAS 12667443 mitochondrial outer membrane GO:0005741 TAS GO:0005741 mitochondrial outer membrane IEA GO:0005743 mitochondrial inner membrane IEA GO:0005759 mitochondrial matrix IDA 21840391 centrosome GO:0005813 IEA GO:0005829 cytosol IEA GO:0016021 integral component of membrane IEA GO:0030054 cell junction IEA GO:0030672 synaptic vesicle membrane IEA GO:0031965 nuclear membrane IDA 21199865 Bcl-2 family protein complex GO:0097136,cytokinesis IMP 21840391 GO:0000910 ovarian follicle development IEA GO:0001541 in utero embryonic development IEA GO:0001701 release of cytochrome c from mitochondria IDA 9843949 GO:0001836 endocytosis IEA GO:0006897 mitotic cell cycle checkpoint IMP 21840391 GO:0007093 germ cell development IEA GO:0007281 spermatogenesis IEA GO:0007283 cell proliferation IEA GO:0008283 positive regulation of cell proliferation IEA GO:0008284 male gonad development IEA GO:0008584 intrinsic apoptotic signaling pathway in response to DNA damage IEA GO:0008630 apoptotic mitochondrial changes TAS 9393856 GO:0008637 fertilization IEA GO:0009566 suppression by virus of host apoptotic process IDA 15231831 GO:0019050 response to cytokine IDA 9184696 GO:0034097 growth IEA GO:0040007 negative regulation of apoptotic process IDA 7650367 9388232 GO:0043066 negative regulation of neuron apoptotic process IEA GO:0043524 response to cycloheximide IEA GO:0046898 regulation of mitochondrial membrane permeability IDA 9843949 GO:0046902 neuron apoptotic process IEA GO:0051402 regulation of mitochondrial membrane potential IDA 9843949 GO:0051881 cellular process regulating host cell cycle in response to virus IEA GO:0060154 mitochondrion morphogenesis IEA GO:0070584 cellular response to amino acid stimulus IEA GO:0071230 cellular response to alkaloid IEA GO:0071312 cellular response to gamma radiation IEA GO:0071480 apoptotic process in bone marrow IEA GO:0071839 negative regulation of establishment of protein localization to plasma membrane IDA 21041309 GO:0090005 negative regulation of release of cytochrome c from mitochondria IC 21041309 GO:0090201 extrinsic apoptotic signaling pathway in absence of ligand IEA GO:0097192 hepatocyte apoptotic process IEA GO:0097284 negative regulation of execution phase of apoptosis IDA 20673843 GO:1900118 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IDA 16608847 GO:1902230 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand TAS 8358789 GO:2001240 negative regulation of intrinsic apoptotic signaling pathway IDA 12011449 GO:2001243 positive regulation of intrinsic apoptotic signaling pathway TAS GO:2001244,protein binding IPI 9027312 9388232 10837489 11054413 11060313 11126360 11278245 11463391 11714801 11971963 12011449 12667443 12815463 14596824 14739602 14752512 14963330 15110758 15901672 16151013 16189514 16608847 16697956 17289999 17418785 17446862 17525735 19060904 19074440 19427857 20010695 20541605 21081150 21199865 21458670 21567405 21671007 21988832 22516262 23055042 23680104 25241761 25296756 25416956 GO:0005515 protein kinase binding IPI 21840391 GO:0019901 identical protein binding IPI 21856303 GO:0042802 protein homodimerization activity IBA GO:0042803 protein heterodimerization activity IBA GO:0046982 BH3 domain binding IPI 21639858 GO:0051434,hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04064 NF-kappa B signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04210 Apoptosis - Homo sapiens (human) hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) hsa05014 Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05166 HTLV-I infection - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) hsa05212 Pancreatic cancer - Homo sapiens (human) hsa05220 Chronic myeloid leukemia - Homo sapiens (human) hsa05222 Small cell lung cancer - Homo sapiens (human),CHEMBL CHEMBL3604174,P16050,Arachidonate 15-lipoxygenase,1.0,PRIMARY,NO,Clc1ccc(NC(=O)c2cn[nH]n2)c(Cl)c1,4,8,"InChI=1S/C9H6Cl2N4O/c10-5-1-2-7(6(11)3-5)13-9(16)8-4-12-15-14-8/h1-4H,(H,13,16)(H,12,14,15)",GAGGCNZJYKWGJL-UHFFFAOYSA-N,"c(""Arachidonate 15-lipoxygenase"", ""Arachidonate 5-lipoxygenase"", ""Arachidonate 12-lipoxygenase"", ""Cyclooxygenase-2"", ""Unchecked"")",246,LOX15,Metabolism R-HSA-1430728 Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 Synthesis of 12-eicosatetraenoic acid derivatives R-HSA-2142712 Arachidonic acid metabolism R-HSA-2142753 Synthesis of 15-eicosatetraenoic acid derivatives R-HSA-2142770 Metabolism of lipids and lipoproteins R-HSA-556833,lipid particle GO:0005811 19528634 IDA cytosol GO:0005829 17052953 21831839 IDA cytosol GO:0005829 ISS cytosol GO:0005829 TAS plasma membrane GO:0005886 ISS membrane GO:0016020 21831839 IDA extrinsic component of cytoplasmic side of plasma membrane GO:0031234 17052953 IDA,GO:0001503 ossification ISS GO:0002820 negative regulation of adaptive immune response ISS GO:0006646 phosphatidylethanolamine biosynthetic process ISS GO:0006691 leukotriene metabolic process TAS GO:0006954 inflammatory response 10200270 TAS GO:0010811 positive regulation of cell-substrate adhesion 11278875 IDA GO:0019369 arachidonic acid metabolic process 1944593 17052953 IDA GO:0019369 arachidonic acid metabolic process 3202857 NAS GO:0019372 lipoxygenase pathway 1944593 IDA GO:0019372 lipoxygenase pathway TAS GO:0030282 bone mineralization ISS GO:0030838 positive regulation of actin filament polymerization ISS GO:0034116 positive regulation of heterotypic cell-cell adhesion IEA GO:0034976 response to endoplasmic reticulum stress ISS GO:0035358 regulation of peroxisome proliferator activated receptor signaling pathway ISS GO:0035963 cellular response to interleukin-13 21831839 IMP GO:0042060 wound healing ISS GO:0043277 apoptotic cell clearance ISS GO:0051122 hepoxilin biosynthetic process ISS GO:0055114 oxidation-reduction process IEA GO:0070374 positive regulation of ERK1 and ERK2 cascade 21831839 IMP GO:0071277 cellular response to calcium ion 17052953 IDA GO:1901074 regulation of engulfment of apoptotic cell ISS GO:2001303 lipoxin A4 biosynthetic process ISS,"GO:0004052 arachidonate 12-lipoxygenase activity 1944593 IDA GO:0004052 arachidonate 12-lipoxygenase activity TAS GO:0005506 iron ion binding ISS GO:0005515 protein binding 21831839 IPI GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 17052953 IDA GO:0047977 hepoxilin-epoxide hydrolase activity IEA GO:0050473 arachidonate 15-lipoxygenase activity 1944593 17052953 IDA GO:0050473 arachidonate 15-lipoxygenase activity 3202857 NAS GO:0050473 arachidonate 15-lipoxygenase activity TAS GO:0051120 hepoxilin A3 synthase activity IEA GO:0097260 eoxin A4 synthase activity TAS",Arachidonic acid metabolism - Homo sapiens (human) hsa00590 Linoleic acid metabolism - Homo sapiens (human) hsa00591 Serotonergic synapse - Homo sapiens (human) hsa04726,CHEMBL CHEMBL3590405,Q6PL18,ATPase family AAA domain-containing protein 2,1.0,PRIMARY,NO,CC1=Cc2c(NC1=O)c(N[C@@H]3CCNC[C@H]3OCC4CCS(=O)(=O)CC4)ccc2c5cncc(C)c5,17,21,"InChI=1S/C27H34N4O4S/c1-17-11-20(14-29-13-17)21-3-4-24(26-22(21)12-18(2)27(32)31-26)30-23-5-8-28-15-25(23)35-16-19-6-9-36(33,34)10-7-19/h3-4,11-14,19,23,25,28,30H,5-10,15-16H2,1-2H3,(H,31,32)/t23-,25-/m1/s1",KXXIBIBXJMYWNL-ILBGXUMGSA-N,"c(""ATPase family AAA domain-containing protein 2"", ""Bromodomain-containing protein 4"", ""Tyrosine-protein kinase BAZ1B"", ""Bromodomain adjacent to zinc finger domain protein 2A"", ""Bromodomain adjacent to zinc finger domain protein 2B"", ""Nucleosome-remodeling factor subunit BPTF"", ""Bromodomain-containing protein 2"", ""Bromodomain-containing protein 3"", ""Bromodomain-containing protein 7"", ""Bromodomain-containing protein 8"", ""Bromodomain-containing protein 9"", ""Bromodomain testis-specific protein"", ""Peregrin"", ""Histone acetyltransferase GCN5"", ""Histone acetyltransferase PCAF"", ""Protein polybromo-1"", ""Transcription initiation factor TFIID subunit 1"")",29028,ATAD2,,nucleus GO:0005634 IBA nucleoplasm GO:0005654 IDA extracellular exosome 19056867 GO:0070062 IDA,"transcription, DNA-templated GO:0006351 IEA chromatin modification GO:0016568 IEA negative regulation of chromatin silencing GO:0031936 IBA positive regulation of transcription, DNA-templated GO:0045893 IDA 17998543 positive regulation of transcription from RNA polymerase II promoter GO:0045944 IBA",chromatin binding GO:0003682 IBA ATP binding GO:0005524 IEA ATPase activity GO:0016887 IDA 17998543 histone binding GO:0042393 IBA,,CHEMBL CHEMBL3092485,Q9UNQ0,ATP-binding cassette sub-family G member 2,1.0,ORTHOGONAL,NO,COc1ccc(cc1OC)c2nc(Nc3cccc(c3)[N+](=O)[O-])c4ccccc4n2,3,6,"InChI=1S/C22H18N4O4/c1-29-19-11-10-14(12-20(19)30-2)21-24-18-9-4-3-8-17(18)22(25-21)23-15-6-5-7-16(13-15)26(27)28/h3-13H,1-2H3,(H,23,24,25)",GREUUZTVKZZOGK-UHFFFAOYSA-N,"c(""Unchecked"", ""Multidrug resistance-associated protein 1"", ""P-glycoprotein 1"", ""ATP-binding cassette sub-family G member 2"")",9429,ABCG2,Metabolism R-HSA-1430728 Abacavir transmembrane transport R-HSA-2161517 Abacavir transport and metabolism R-HSA-2161522 Transmembrane transport of small molecules R-HSA-382551 Iron uptake and transport R-HSA-917937,nucleus IDA GO:0005634 plasma membrane IBA GO:0005886 plasma membrane IDA GO:0005886 plasma membrane TAS GO:0005886 integral component of membrane IEA GO:0016021 apical plasma membrane IEA GO:0016324 mitochondrial membrane IEA GO:0031966,TAS 9850061 transport GO:0006810 IEA GO:0006855 drug transmembrane transport TAS GO:0006879 cellular iron ion homeostasis IEA GO:0010039 response to iron ion IEA GO:0015886 heme transport TAS 9861027 response to drug GO:0042493 IEA GO:0042908 xenobiotic transport IMP 18834626 19503597 20053405 urate metabolic process GO:0046415 IEA GO:0046618 drug export IEA GO:0051593 response to folic acid IEA GO:0060136 embryonic process involved in female pregnancy IEA GO:0071549 cellular response to dexamethasone stimulus,"TAS 9850061 9861027 transporter activity GO:0005215 IPI 18056989 19909340 protein binding GO:0005515 IEA GO:0005524 ATP binding TAS 9861027 xenobiotic-transporting ATPase activity GO:0008559 TAS GO:0015232 heme transporter activity TAS 9850061 ATPase activity, coupled to transmembrane movement of substances GO:0042626 IDA 16870176 protein homodimerization activity GO:0042803",hsa02010 ABC transporters - Homo sapiens (human) hsa04976 Bile secretion - Homo sapiens (human),CHEMBL CHEMBL488910,Q9UNQ0,ATP-binding cassette sub-family G member 2,1.0,PRIMARY,NO,COc1ccc2c3C[C@@H]4N([C@@H](CC(C)C)c3[nH]c2c1)C(=O)[C@H](CCC(=O)OC(C)(C)C)NC4=O,4,41,"InChI=1S/C26H35N3O5/c1-14(2)11-20-23-17(16-8-7-15(33-6)12-19(16)27-23)13-21-24(31)28-18(25(32)29(20)21)9-10-22(30)34-26(3,4)5/h7-8,12,14,18,20-21,27H,9-11,13H2,1-6H3,(H,28,31)/t18-,20-,21-/m0/s1",NXNRAECHCJZNRF-JBACZVJFSA-N,"c(""ATP-binding cassette sub-family G member 2"", ""Canalicular multispecific organic anion transporter 1"", ""P-glycoprotein 1"", ""Multidrug resistance-associated protein 1"", ""Unchecked"")",9429,ABCG2,Metabolism R-HSA-1430728 Abacavir transmembrane transport R-HSA-2161517 Abacavir transport and metabolism R-HSA-2161522 Transmembrane transport of small molecules R-HSA-382551 Iron uptake and transport R-HSA-917937,nucleus IDA GO:0005634 plasma membrane IBA GO:0005886 plasma membrane IDA GO:0005886 plasma membrane TAS GO:0005886 integral component of membrane IEA GO:0016021 apical plasma membrane IEA GO:0016324 mitochondrial membrane IEA GO:0031966,TAS 9850061 transport GO:0006810 IEA GO:0006855 drug transmembrane transport TAS GO:0006879 cellular iron ion homeostasis IEA GO:0010039 response to iron ion IEA GO:0015886 heme transport TAS 9861027 response to drug GO:0042493 IEA GO:0042908 xenobiotic transport IMP 18834626 19503597 20053405 urate metabolic process GO:0046415 IEA GO:0046618 drug export IEA GO:0051593 response to folic acid IEA GO:0060136 embryonic process involved in female pregnancy IEA GO:0071549 cellular response to dexamethasone stimulus,"TAS 9850061 9861027 transporter activity GO:0005215 IPI 18056989 19909340 protein binding GO:0005515 IEA GO:0005524 ATP binding TAS 9861027 xenobiotic-transporting ATPase activity GO:0008559 TAS GO:0015232 heme transporter activity TAS 9850061 ATPase activity, coupled to transmembrane movement of substances GO:0042626 IDA 16870176 protein homodimerization activity GO:0042803",hsa02010 ABC transporters - Homo sapiens (human) hsa04976 Bile secretion - Homo sapiens (human),CHEMBL CHEMBL3612810,P48048,ATP-sensitive inward rectifier potassium channel 1,1.0,ORTHOGONAL,NO,COc1cc(ncc1C#N)[C@@H](O)CN2CCN(C[C@H](O)c3ccc4C(=O)OCc4c3C)CC2,7,11,"InChI=1S/C24H28N4O5/c1-15-17(3-4-18-19(15)14-33-24(18)31)21(29)12-27-5-7-28(8-6-27)13-22(30)20-9-23(32-2)16(10-25)11-26-20/h3-4,9,11,21-22,29-30H,5-8,12-14H2,1-2H3/t21-,22-/m0/s1",QZUKGDYPSXQBSQ-VXKWHMMOSA-N,"c(""ATP-sensitive inward rectifier potassium channel 1"", ""Unchecked"", ""Inward rectifier potassium channel 4"", ""Inward rectifier potassium channel 2"", ""ATP-sensitive inward rectifier potassium channel 10"", ""Inward rectifier potassium channel 13"", ""Sodium channel protein type II alpha subunit"", ""Sodium channel protein type VII alpha subunit"")",3758,KCNJ1,R-HSA-112316 Neuronal System R-HSA-1296065 Inwardly rectifying K+ channels R-HSA-1296067 Potassium transport channels R-HSA-1296071 Potassium Channels,GO:0005886 plasma membrane TAS GO:0008076 voltage-gated potassium channel complex 9015377 TAS,9015377 TAS GO:0006813 potassium ion transport 9015377 TAS GO:0007588 excretion IBA GO:0010107 potassium ion import IEA GO:0034765 regulation of ion transmembrane transport IEA GO:0035864 response to potassium ion IEA GO:0043066 negative regulation of apoptotic process IEA GO:0071286 cellular response to magnesium ion,"TAS GO:0005242 inward rectifier potassium channel activity IEA GO:0005524 ATP binding 12086641 IDA GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IBA GO:0015272 ATP-activated inward rectifier potassium channel activity IEA GO:0030955 potassium ion binding IEA GO:0042277 peptide binding",Aldosterone-regulated sodium reabsorption - Homo sapiens (human) hsa04960 Gastric acid secretion - Homo sapiens (human) hsa04971,CHEMBL CHEMBL2441437,P48048,ATP-sensitive inward rectifier potassium channel 1,1.0,PRIMARY,NO,O=C(Cc1ccc(cc1)n2cnnn2)N3CCN(CCc4ccc5C(=O)OCc5c4)CC3,8,13,"InChI=1S/C23H24N6O3/c30-22(14-17-1-4-20(5-2-17)29-16-24-25-26-29)28-11-9-27(10-12-28)8-7-18-3-6-21-19(13-18)15-32-23(21)31/h1-6,13,16H,7-12,14-15H2",LKLRNYYBQWYHND-UHFFFAOYSA-N,"c(""Serotonin transporter"", ""Voltage-gated L-type calcium channel alpha-1C subunit"", ""Sodium channel protein type V alpha subunit"", ""Inward rectifier potassium channel 13"", ""ATP-sensitive inward rectifier potassium channel 10"", ""Inward rectifier potassium channel 4"", ""Inward rectifier potassium channel 2"", ""Unchecked"", ""ATP-sensitive inward rectifier potassium channel 1"")",3758,KCNJ1,R-HSA-112316 Neuronal System R-HSA-1296065 Inwardly rectifying K+ channels R-HSA-1296067 Potassium transport channels R-HSA-1296071 Potassium Channels,GO:0005886 plasma membrane TAS GO:0008076 voltage-gated potassium channel complex 9015377 TAS,9015377 TAS GO:0006813 potassium ion transport 9015377 TAS GO:0007588 excretion IBA GO:0010107 potassium ion import IEA GO:0034765 regulation of ion transmembrane transport IEA GO:0035864 response to potassium ion IEA GO:0043066 negative regulation of apoptotic process IEA GO:0071286 cellular response to magnesium ion,"TAS GO:0005242 inward rectifier potassium channel activity IEA GO:0005524 ATP binding 12086641 IDA GO:0005546 phosphatidylinositol-4,5-bisphosphate binding IBA GO:0015272 ATP-activated inward rectifier potassium channel activity IEA GO:0030955 potassium ion binding IEA GO:0042277 peptide binding",Aldosterone-regulated sodium reabsorption - Homo sapiens (human) hsa04960 Gastric acid secretion - Homo sapiens (human) hsa04971,CHEMBL CHEMBL3613709,Q09327,"Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase",1.0,PRIMARY,NO,COc1cccc(CC(=O)N2Cc3ccc(cc3C2)S(=O)(=O)Nc4cnn(n4)C5CCC5)c1,6,11,"InChI=1S/C23H25N5O4S/c1-32-20-7-2-4-16(10-20)11-23(29)27-14-17-8-9-21(12-18(17)15-27)33(30,31)26-22-13-24-28(25-22)19-5-3-6-19/h2,4,7-10,12-13,19H,3,5-6,11,14-15H2,1H3,(H,25,26)",GRXCLNMCJWKTAT-UHFFFAOYSA-N,"c(""Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase"", ""Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"", ""Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase"", ""Diacylglycerol O-acyltransferase 1"", ""Diacylglycerol O-acyltransferase 2"", ""Unchecked"", ""Peroxisome proliferator-activated receptor gamma"")",4248,MGAT3,R-HSA-392499 Metabolism of proteins R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-975574 Reactions specific to the hybrid N-glycan synthesis pathway R-HSA-975576 N-glycan antennae elongation in the medial/trans-Golgi,Golgi membrane GO:0000139 TAS integral component of membrane GO:0016021 IEA,protein N-linked glycosylation GO:0006487 IEA,"beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity GO:0003830 TAS",hsa00510 N-Glycan biosynthesis - Homo sapiens (human),CHEMBL CHEMBL200234,P08588,Beta-1 adrenergic receptor,1.0,PRIMARY,NO,C1CN(CCN1)c2cccc3[nH]ccc23,6,7,"InChI=1S/C12H15N3/c1-2-11-10(4-5-14-11)12(3-1)15-8-6-13-7-9-15/h1-5,13-14H,6-9H2",YZKSXUIOKWQABW-UHFFFAOYSA-N,"c(""Serotonin 6 (5-HT6) receptor"", ""Beta-1 adrenergic receptor"", ""Muscarinic acetylcholine receptor M4"", ""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M1"")",153,ADRB1,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Amine ligand-binding receptors R-HSA-375280 GPCR downstream signaling R-HSA-388396 Adrenoceptors R-HSA-390696 G alpha (s) signalling events R-HSA-418555 GPCR ligand binding R-HSA-500792,IDA 21540189 early endosome GO:0005769 IDA 11526121 21540189 plasma membrane GO:0005886 TAS GO:0005886 plasma membrane TAS 10212248 integral component of plasma membrane GO:0005887,temperature homeostasis GO:0001659 IBA positive regulation of heart rate by epinephrine-norepinephrine GO:0001996 IBA positive regulation of the force of heart contraction by epinephrine-norepinephrine GO:0001997 IEA diet induced thermogenesis GO:0002024 IEA vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure GO:0002025 IBA activation of adenylate cyclase activity 10212248 GO:0007190 TAS cell-cell signaling GO:0007267 IBA response to cold GO:0009409 IEA positive regulation of cAMP biosynthetic process 12391161 12529373 GO:0030819 IDA heat generation GO:0031649 IEA negative regulation of multicellular organism growth GO:0040015 IEA fear response GO:0042596 IEA positive regulation of GTPase activity 12391161 GO:0043547 IDA positive regulation of cAMP-mediated signaling 12391161 GO:0043950 IDA brown fat cell differentiation GO:0050873 IEA adenylate cyclase-activating adrenergic receptor signaling pathway 12391161 GO:0071880 IDA,beta-adrenergic receptor activity 8892658 GO:0004939 TAS beta1-adrenergic receptor activity GO:0004940 IEA receptor signaling protein activity 12391161 GO:0005057 IDA Ras guanyl-nucleotide exchange factor activity 12391161 GO:0005088 IDA protein binding 12391161 16316992 23381222 GO:0005515 IPI PDZ domain binding 11526121 GO:0030165 IPI alpha-2A adrenergic receptor binding 12529373 GO:0031694 IPI protein heterodimerization activity 12529373 GO:0046982 IPI epinephrine binding GO:0051379 IBA norepinephrine binding GO:0051380 IBA,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04144 Endocytosis - Homo sapiens (human) hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04540 Gap junction - Homo sapiens (human) hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04924 Renin secretion - Homo sapiens (human) hsa04970 Salivary secretion - Homo sapiens (human) hsa05414 Dilated cardiomyopathy - Homo sapiens (human),CHEMBL CHEMBL1256786,P07550,Beta-2 adrenergic receptor,1.0,PRIMARY,NO,COc1ccc(CC(C)NCC(O)c2ccc(O)c(NC=O)c2)cc1,4,46,"InChI=1S/C19H24N2O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22)",BPZSYCZIITTYBL-UHFFFAOYSA-N,"c(""Beta-2 adrenergic receptor"", ""Beta-1 adrenergic receptor"", ""Beta-3 adrenergic receptor"", ""Dopamine D2 receptor"", ""Unchecked"", ""Glutaminase kidney isoform, mitochondrial"", ""Dopamine D3 receptor"")",154,ADRB2,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375280 Amine ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-390696 Adrenoceptors R-HSA-418555 G alpha (s) signalling events R-HSA-500792 GPCR ligand binding,IEA GO:0005634 nucleus 9507004 TAS GO:0005764 lysosome 10734107 TAS GO:0005768 endosome IEA GO:0005769 early endosome 9235896 IDA GO:0005886 plasma membrane TAS GO:0005886 plasma membrane 12297500 IDA GO:0005887 integral component of plasma membrane IEA GO:0005901 caveola IEA GO:0016324 apical plasma membrane IEA GO:0030424 axon IEA GO:0032809 neuronal cell body membrane IEA GO:0042383 sarcolemma IEA GO:0043197 dendritic spine 15123695 23382219 IDA GO:0043235 receptor complex,"GO:0002024 diet induced thermogenesis IEA GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure IBA 15123695 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin IDA GO:0002086 diaphragm contraction IEA GO:0003059 positive regulation of the force of heart contraction by epinephrine IEA 15123695 GO:0006898 receptor-mediated endocytosis IDA 1371121 GO:0007166 cell surface receptor signaling pathway TAS 10734107 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity TAS 2823249 GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS 15123695 GO:0007190 activation of adenylate cyclase activity IDA GO:0007267 cell-cell signaling IBA GO:0007565 female pregnancy IEA GO:0007568 aging IEA GO:0008284 positive regulation of cell proliferation IEA GO:0008306 associative learning IEA 9507004 GO:0008333 endosome to lysosome transport TAS GO:0009409 response to cold IEA GO:0010765 positive regulation of sodium ion transport IEA GO:0016525 negative regulation of angiogenesis IEA GO:0030279 negative regulation of ossification IEA GO:0030501 positive regulation of bone mineralization IEA 19372219 GO:0031398 positive regulation of protein ubiquitination IMP GO:0031649 heat generation IEA GO:0032570 response to progesterone IEA GO:0032781 positive regulation of ATPase activity IEA GO:0033574 response to testosterone IEA GO:0035249 synaptic transmission, glutamatergic IEA GO:0035811 negative regulation of urine volume IEA GO:0040015 negative regulation of multicellular organism growth IEA GO:0042060 wound healing IEA GO:0043065 positive regulation of apoptotic process IEA GO:0043268 positive regulation of potassium ion transport IEA 15123695 GO:0043410 positive regulation of MAPK cascade IDA GO:0043627 response to estrogen IEA GO:0044849 estrous cycle IEA GO:0045453 bone resorption IEA GO:0045909 positive regulation of vasodilation IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0045986 negative regulation of smooth muscle contraction IBA GO:0048633 positive regulation of skeletal muscle tissue growth IEA GO:0050728 negative regulation of inflammatory response IEA GO:0050873 brown fat cell differentiation IEA GO:0051924 regulation of calcium ion transport IEA GO:0051930 regulation of sensory perception of pain IEA GO:0060079 excitatory postsynaptic potential IEA GO:0071456 cellular response to hypoxia IEA GO:0071548 response to dexamethasone IEA GO:0071867 response to monoamine IEA GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA GO:0090331 negative regulation of platelet aggregation IEA GO:0097421 liver regeneration IEA 23708524 GO:1901098 positive regulation of autophagosome maturation IDA 23708524 GO:1904504 positive regulation of lipophagy IDA 22020285 GO:1904925 positive regulation of mitophagy in response to mitochondrial depolarization IGI",GO:0001965 G-protein alpha-subunit binding IEA 15123695 GO:0004941 beta2-adrenergic receptor activity IDA 9560162 9671706 15123695 17170700 19424180 19584355 20353789 20733053 23208550 23236378 24405750 GO:0005515 protein binding IPI GO:0008144 drug binding IEA GO:0008179 adenylate cyclase binding IEA 12297500 GO:0015459 potassium channel regulator activity IDA GO:0031713 B2 bradykinin receptor binding IEA GO:0032403 protein complex binding IEA GO:0035240 dopamine binding IEA GO:0035255 ionotropic glutamate receptor binding IEA 15123695 GO:0042803 protein homodimerization activity IDA GO:0051379 epinephrine binding IBA 15123695 GO:0051380 norepinephrine binding IDA,Calcium signaling pathway - Homo sapiens (human) hsa04020 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 cAMP signaling pathway - Homo sapiens (human) hsa04024 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Endocytosis - Homo sapiens (human) hsa04144 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04261 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04923 Renin secretion - Homo sapiens (human) hsa04924 Salivary secretion - Homo sapiens (human) hsa04970,CHEMBL CHEMBL1263,P07550,Beta-2 adrenergic receptor,1.0,PRIMARY,YES,OCc1cc(ccc1O)C(O)CNCCCCCCOCCCCc2ccccc2,4,116,"InChI=1S/C25H37NO4/c27-20-23-18-22(13-14-24(23)28)25(29)19-26-15-7-1-2-8-16-30-17-9-6-12-21-10-4-3-5-11-21/h3-5,10-11,13-14,18,25-29H,1-2,6-9,12,15-17,19-20H2",GIIZNNXWQWCKIB-UHFFFAOYSA-N,"c(""Adrenergic receptor alpha-1"", ""Beta-2 adrenergic receptor"", ""MES-SA"", ""Adrenergic receptor beta; ADRB1 & ADRB2"", ""Unchecked"", ""Beta-1 adrenergic receptor"", ""Beta-3 adrenergic receptor"", ""Lysine-specific demethylase 4D-like"", ""Beta-glucocerebrosidase"", ""Androgen Receptor"", ""Dopamine D3 receptor"")",154,ADRB2,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375280 Amine ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-390696 Adrenoceptors R-HSA-418555 G alpha (s) signalling events R-HSA-500792 GPCR ligand binding,IEA GO:0005634 nucleus 9507004 TAS GO:0005764 lysosome 10734107 TAS GO:0005768 endosome IEA GO:0005769 early endosome 9235896 IDA GO:0005886 plasma membrane TAS GO:0005886 plasma membrane 12297500 IDA GO:0005887 integral component of plasma membrane IEA GO:0005901 caveola IEA GO:0016324 apical plasma membrane IEA GO:0030424 axon IEA GO:0032809 neuronal cell body membrane IEA GO:0042383 sarcolemma IEA GO:0043197 dendritic spine 15123695 23382219 IDA GO:0043235 receptor complex,"GO:0002024 diet induced thermogenesis IEA GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure IBA 15123695 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin IDA GO:0002086 diaphragm contraction IEA GO:0003059 positive regulation of the force of heart contraction by epinephrine IEA 15123695 GO:0006898 receptor-mediated endocytosis IDA 1371121 GO:0007166 cell surface receptor signaling pathway TAS 10734107 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity TAS 2823249 GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS 15123695 GO:0007190 activation of adenylate cyclase activity IDA GO:0007267 cell-cell signaling IBA GO:0007565 female pregnancy IEA GO:0007568 aging IEA GO:0008284 positive regulation of cell proliferation IEA GO:0008306 associative learning IEA 9507004 GO:0008333 endosome to lysosome transport TAS GO:0009409 response to cold IEA GO:0010765 positive regulation of sodium ion transport IEA GO:0016525 negative regulation of angiogenesis IEA GO:0030279 negative regulation of ossification IEA GO:0030501 positive regulation of bone mineralization IEA 19372219 GO:0031398 positive regulation of protein ubiquitination IMP GO:0031649 heat generation IEA GO:0032570 response to progesterone IEA GO:0032781 positive regulation of ATPase activity IEA GO:0033574 response to testosterone IEA GO:0035249 synaptic transmission, glutamatergic IEA GO:0035811 negative regulation of urine volume IEA GO:0040015 negative regulation of multicellular organism growth IEA GO:0042060 wound healing IEA GO:0043065 positive regulation of apoptotic process IEA GO:0043268 positive regulation of potassium ion transport IEA 15123695 GO:0043410 positive regulation of MAPK cascade IDA GO:0043627 response to estrogen IEA GO:0044849 estrous cycle IEA GO:0045453 bone resorption IEA GO:0045909 positive regulation of vasodilation IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0045986 negative regulation of smooth muscle contraction IBA GO:0048633 positive regulation of skeletal muscle tissue growth IEA GO:0050728 negative regulation of inflammatory response IEA GO:0050873 brown fat cell differentiation IEA GO:0051924 regulation of calcium ion transport IEA GO:0051930 regulation of sensory perception of pain IEA GO:0060079 excitatory postsynaptic potential IEA GO:0071456 cellular response to hypoxia IEA GO:0071548 response to dexamethasone IEA GO:0071867 response to monoamine IEA GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA GO:0090331 negative regulation of platelet aggregation IEA GO:0097421 liver regeneration IEA 23708524 GO:1901098 positive regulation of autophagosome maturation IDA 23708524 GO:1904504 positive regulation of lipophagy IDA 22020285 GO:1904925 positive regulation of mitophagy in response to mitochondrial depolarization IGI",GO:0001965 G-protein alpha-subunit binding IEA 15123695 GO:0004941 beta2-adrenergic receptor activity IDA 9560162 9671706 15123695 17170700 19424180 19584355 20353789 20733053 23208550 23236378 24405750 GO:0005515 protein binding IPI GO:0008144 drug binding IEA GO:0008179 adenylate cyclase binding IEA 12297500 GO:0015459 potassium channel regulator activity IDA GO:0031713 B2 bradykinin receptor binding IEA GO:0032403 protein complex binding IEA GO:0035240 dopamine binding IEA GO:0035255 ionotropic glutamate receptor binding IEA 15123695 GO:0042803 protein homodimerization activity IDA GO:0051379 epinephrine binding IBA 15123695 GO:0051380 norepinephrine binding IDA,Calcium signaling pathway - Homo sapiens (human) hsa04020 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 cAMP signaling pathway - Homo sapiens (human) hsa04024 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Endocytosis - Homo sapiens (human) hsa04144 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04261 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04923 Renin secretion - Homo sapiens (human) hsa04924 Salivary secretion - Homo sapiens (human) hsa04970,CHEMBL CHEMBL401473,P56817,Beta-secretase 1,1.0,ORTHOGONAL,NO,CCNc1cc(cc(c1)C(=O)N[C@@H](Cc2ccccc2)[C@H](O)CNCc3cccc(c3)C(F)(F)F)N4CCCCS4(=O)=O,3,16,"InChI=1S/C31H37F3N4O4S/c1-2-36-26-17-24(18-27(19-26)38-13-6-7-14-43(38,41)42)30(40)37-28(16-22-9-4-3-5-10-22)29(39)21-35-20-23-11-8-12-25(15-23)31(32,33)34/h3-5,8-12,15,17-19,28-29,35-36,39H,2,6-7,13-14,16,20-21H2,1H3,(H,37,40)/t28-,29+/m0/s1",GPMRAYXRPZKTFK-URLMMPGGSA-N,"c(""Beta-secretase 1"", ""Beta secretase 2"", ""Cathepsin D"", ""Unchecked"")",23621,BACE1,,endosome GO:0005768 10531052 IDA late endosome GO:0005770 24612608 IDA multivesicular body GO:0005771 24612608 IDA endoplasmic reticulum lumen GO:0005788 TAS Golgi apparatus GO:0005794 10531052 11466313 12586838 IDA trans-Golgi network GO:0005802 11466313 IDA plasma membrane GO:0005886 24612608 IDA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 12586838 IDA cell surface GO:0009986 IEA endosome membrane GO:0010008 TAS integral component of membrane GO:0016021 10531052 NAS axon GO:0030424 IEA cytoplasmic vesicle membrane GO:0030659 IEA Golgi-associated vesicle lumen GO:0070931 TAS,proteolysis IDA 10531052 GO:0006508 membrane protein ectodomain proteolysis IDA 18353773 GO:0006509 membrane protein ectodomain proteolysis TAS 12354787 GO:0006509 protein catabolic process IBA GO:0030163 cellular protein metabolic process TAS GO:0044267 beta-amyloid metabolic process IDA 15080893 GO:0050435,beta-amyloid binding IPI 16407538 GO:0001540 aspartic-type endopeptidase activity IDA 10531052 GO:0004190 protein binding IPI 16407538 19011241 22709416 24612608 25957769 GO:0005515 peptidase activity IDA 8562317 GO:0008233 beta-aspartyl-peptidase activity TAS GO:0008798 enzyme binding IPI 12586838 GO:0019899,"hsa05010 Alzheimer,s disease - Homo sapiens (human)",CHEMBL CHEMBL576258,P56817,Beta-secretase 1,1.0,PRIMARY,NO,NC1=N[C@](C2=NCCCN12)(c3ccc(OC(F)(F)F)cc3)c4cccc(c4)c5cccnc5F,4,10,"InChI=1S/C24H19F4N5O/c25-20-19(6-2-11-30-20)15-4-1-5-17(14-15)23(21-31-12-3-13-33(21)22(29)32-23)16-7-9-18(10-8-16)34-24(26,27)28/h1-2,4-11,14H,3,12-13H2,(H2,29,32)/t23-/m1/s1",OPSMDCTXTURNQW-HSZRJFAPSA-N,"c(""Unchecked"", ""Cathepsin D"", ""Renin"", ""Beta secretase 2"", ""Beta-secretase 1"")",23621,BACE1,,endosome GO:0005768 10531052 IDA late endosome GO:0005770 24612608 IDA multivesicular body GO:0005771 24612608 IDA endoplasmic reticulum lumen GO:0005788 TAS Golgi apparatus GO:0005794 10531052 11466313 12586838 IDA trans-Golgi network GO:0005802 11466313 IDA plasma membrane GO:0005886 24612608 IDA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 12586838 IDA cell surface GO:0009986 IEA endosome membrane GO:0010008 TAS integral component of membrane GO:0016021 10531052 NAS axon GO:0030424 IEA cytoplasmic vesicle membrane GO:0030659 IEA Golgi-associated vesicle lumen GO:0070931 TAS,proteolysis IDA 10531052 GO:0006508 membrane protein ectodomain proteolysis IDA 18353773 GO:0006509 membrane protein ectodomain proteolysis TAS 12354787 GO:0006509 protein catabolic process IBA GO:0030163 cellular protein metabolic process TAS GO:0044267 beta-amyloid metabolic process IDA 15080893 GO:0050435,beta-amyloid binding IPI 16407538 GO:0001540 aspartic-type endopeptidase activity IDA 10531052 GO:0004190 protein binding IPI 16407538 19011241 22709416 24612608 25957769 GO:0005515 peptidase activity IDA 8562317 GO:0008233 beta-aspartyl-peptidase activity TAS GO:0008798 enzyme binding IPI 12586838 GO:0019899,"hsa05010 Alzheimer,s disease - Homo sapiens (human)",CHEMBL CHEMBL3335672,Q96RI1,Bile acid receptor FXR,1.0,PRIMARY,NO,COc1ccc(C(=O)Nc2cccc(c2)C(=O)O)c(NC(=O)c3ccc(cc3)C(C)(C)C)c1,4,35,"InChI=1S/C26H26N2O5/c1-26(2,3)18-10-8-16(9-11-18)23(29)28-22-15-20(33-4)12-13-21(22)24(30)27-19-7-5-6-17(14-19)25(31)32/h5-15H,1-4H3,(H,27,30)(H,28,29)(H,31,32)",NGPVBEGYGDKDJE-UHFFFAOYSA-N,"c(""Bile acid receptor FXR"", ""G-protein coupled bile acid receptor 1"", ""Peroxisome proliferator-activated receptor delta"", ""Peroxisome proliferator-activated receptor gamma"", ""Peroxisome proliferator-activated receptor alpha"", ""Unchecked"")",9971,NR1H4,Metabolism R-HSA-1430728 Recycling of bile acids and salts R-HSA-159418 Synthesis of bile acids and bile salts R-HSA-192105 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 Bile acid and bile salt metabolism R-HSA-194068 Biological oxidations R-HSA-211859 Cytochrome P450 - arranged by substrate type R-HSA-211897 Phase 1 - Functionalization of compounds R-HSA-211945 Endogenous sterols R-HSA-211976 Generic Transcription Pathway R-HSA-212436 Nuclear Receptor transcription pathway R-HSA-383280 Metabolism of lipids and lipoproteins R-HSA-556833 Gene Expression R-HSA-74160,nucleoplasm GO:0005654 TAS nuclear euchromatin 21757002 GO:0005719 IDA,GO:0000122 negative regulation of transcription from RNA polymerase II promoter 21757002 ISS GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter 21757002 IC GO:0006109 regulation of carbohydrate metabolic process IEA GO:0006367 transcription initiation from RNA polymerase II promoter TAS GO:0006954 inflammatory response IEA GO:0007165 signal transduction 10334993 TAS GO:0007219 Notch signaling pathway IEA GO:0008206 bile acid metabolic process IEA GO:0009749 response to glucose IEA GO:0010988 regulation of low-density lipoprotein particle clearance 12660231 IDA GO:0015721 bile acid and bile salt transport TAS GO:0030522 intracellular receptor signaling pathway ISS GO:0032496 response to lipopolysaccharide IEA GO:0034142 toll-like receptor 4 signaling pathway 19864602 IDA GO:0034255 regulation of urea metabolic process 21757002 ISS GO:0034971 histone H3-R17 methylation 15471871 IDA GO:0035356 cellular triglyceride homeostasis 20447400 IDA GO:0038183 bile acid signaling pathway ISS GO:0038185 intracellular bile acid receptor signaling pathway 10334992 IDA GO:0043066 negative regulation of apoptotic process 20447400 IDA GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling 21242261 IDA GO:0043401 steroid hormone mediated signaling pathway IEA GO:0045087 innate immune response IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter 21757002 IMP GO:0048565 digestive tract development IEA GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus 20447400 IDA GO:0070857 regulation of bile acid biosynthetic process 21757002 TAS GO:0070858 negative regulation of bile acid biosynthetic process 10334992 IDA GO:0071398 cellular response to fatty acid 20447400 IDA GO:0071417 cellular response to organonitrogen compound 21757002 ISS GO:0072615 interleukin-17 secretion 21242261 IDA GO:0090181 regulation of cholesterol metabolic process 21757002 TAS GO:1902714 negative regulation of interferon-gamma secretion 21242261 IDA GO:1904468 negative regulation of tumor necrosis factor secretion 21242261 IDA GO:2000213 positive regulation of glutamate metabolic process 21757002 ISS GO:2001250 positive regulation of ammonia assimilation cycle IEA,"GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding 21757002 IDA GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding 24211198 IDA GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding 21757002 IDA GO:0003700 transcription factor activity, sequence-specific DNA binding 9223286 10334992 TAS GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding 21757002 IDA GO:0003707 steroid hormone receptor activity IEA GO:0003713 transcription coactivator activity 10334992 TAS GO:0003714 transcription corepressor activity 10334992 TAS GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding 21757002 ISS GO:0004887 thyroid hormone receptor activity IEA GO:0005515 protein binding 12917342 14684751 14701856 15317749 19833092 21532585 22345554 IPI GO:0008270 zinc ion binding IEA GO:0016922 ligand-dependent nuclear receptor binding 21757002 TAS GO:0032052 bile acid binding 21757002 ISS GO:0032052 bile acid binding 21757002 TAS GO:0038181 bile acid receptor activity 10334992 IDA GO:0042277 peptide binding IEA GO:0043565 sequence-specific DNA binding 12815072 IDA GO:0046965 retinoid X receptor binding IEA GO:1902122 chenodeoxycholic acid binding 10334992 IDA",Bile secretion - Homo sapiens (human) hsa04976,CHEMBL CHEMBL1672352,P32247,Bombesin receptor subtype-3,1.0,ORTHOGONAL,YES,CC(C)(C)Cc1c[nH]c(CC(C)(O)c2ccc(cc2)c3ccc(F)cn3)n1,4,7,"InChI=1S/C22H26FN3O/c1-21(2,3)11-18-14-25-20(26-18)12-22(4,27)16-7-5-15(6-8-16)19-10-9-17(23)13-24-19/h5-10,13-14,27H,11-12H2,1-4H3,(H,25,26)",SQDJZWNPXIGNRP-UHFFFAOYSA-N,"c(""Bombesin receptor subtype-3"", ""Neuromedin B receptor"", ""Gastrin releasing peptide receptor"", ""Unchecked"", ""Pregnane X receptor"")",680,BRS3,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,GO:0005886 plasma membrane IEA GO:0016021 integral component of membrane IEA GO:0043005 neuron projection IEA GO:0043025 neuronal cell body IEA,glucose metabolic process GO:0006006 TAS 9367152 regulation of blood pressure GO:0008217 TAS 9367152 adult feeding behavior GO:0008343 TAS 9367152 bombesin receptor signaling pathway GO:0031989 IEA,bombesin receptor activity GO:0004946 IEA,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL1091720,P32247,Bombesin receptor subtype-3,1.0,PRIMARY,YES,CCC(C)(C)Cc1c[nH]c(CCc2ccc(cc2)c3ccccn3)n1,4,11,"InChI=1S/C22H27N3/c1-4-22(2,3)15-19-16-24-21(25-19)13-10-17-8-11-18(12-9-17)20-7-5-6-14-23-20/h5-9,11-12,14,16H,4,10,13,15H2,1-3H3,(H,24,25)",WVAKRQOMAINQPU-UHFFFAOYSA-N,"c(""Bombesin receptor subtype-3"", ""Neuromedin B receptor"", ""Gastrin releasing peptide receptor"", ""Unchecked"", ""Pregnane X receptor"")",680,BRS3,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,GO:0005886 plasma membrane IEA GO:0016021 integral component of membrane IEA GO:0043005 neuron projection IEA GO:0043025 neuronal cell body IEA,glucose metabolic process GO:0006006 TAS 9367152 regulation of blood pressure GO:0008217 TAS 9367152 adult feeding behavior GO:0008343 TAS 9367152 bombesin receptor signaling pathway GO:0031989 IEA,bombesin receptor activity GO:0004946 IEA,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL226630,P13497,Bone morphogenetic protein 1,1.0,PRIMARY,NO,NC(=O)c1noc(n1)[C@H](CCCC2CCCCC2)CC(=O)NO,10,44,"InChI=1S/C15H24N4O4/c16-13(21)14-17-15(23-19-14)11(9-12(20)18-22)8-4-7-10-5-2-1-3-6-10/h10-11,22H,1-9H2,(H2,16,21)(H,18,20)/t11-/m1/s1",ARJCBSRIPGJMAD-LLVKDONJSA-N,"c(""Skin"", ""Bone morphogenetic protein 1"", ""Matrix metalloproteinase-1"", ""Matrix metalloproteinase-2"", ""Matrix metalloproteinase 3"", ""Matrix metalloproteinase 9"", ""Matrix metalloproteinase 14"", ""Unchecked"", ""Phosphodiesterase 4A"", ""Phosphodiesterase 4B"", ""Phosphodiesterase 4C"", ""Phosphodiesterase 4D"")",649,BMP1,"R-HSA-1430728 Metabolism R-HSA-1474228 Degradation of the extracellular matrix R-HSA-1474244 Extracellular matrix organization R-HSA-1474290 Collagen formation R-HSA-1650814 Collagen biosynthesis and modifying enzymes R-HSA-174824 Lipoprotein metabolism R-HSA-194223 HDL-mediated lipid transport R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures R-HSA-2214320 Anchoring fibril formation R-HSA-2243919 Crosslinking of collagen fibrils R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-73923 Lipid digestion, mobilization, and transport",extracellular region TAS GO:0005576 proteinaceous extracellular matrix IEA GO:0005578 extracellular space IBA GO:0005615 Golgi apparatus IEA GO:0005794 membrane-bounded vesicle IEA GO:0031988,NAS 7798260 skeletal system development GO:0001501 TAS 3201241 cartilage condensation GO:0001502 IEA GO:0001503 ossification IDA 16824737 proteolysis GO:0006508 TAS 7798260 multicellular organism development GO:0007275 IBA GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation TAS GO:0022617 extracellular matrix disassembly IBA GO:0030509 BMP signaling pathway TAS GO:0042157 lipoprotein metabolic process IBA GO:0042981 regulation of apoptotic process IBA GO:0043408 regulation of MAPK cascade IBA GO:0048468 cell development IBA GO:0060395 SMAD protein signal transduction IDA 3201241 positive regulation of cartilage development GO:0061036,TAS GO:0004222 metalloendopeptidase activity TAS GO:0004252 serine-type endopeptidase activity IBA GO:0005125 cytokine activity IBA GO:0005160 transforming growth factor beta receptor binding IEA GO:0005509 calcium ion binding IPI 23829672 25543063 protein binding GO:0005515 IEA GO:0008083 growth factor activity IDA 12393877 16824737 peptidase activity GO:0008233 NAS 7798260 metallopeptidase activity GO:0008237 IEA GO:0008270 zinc ion binding,,CHEMBL CHEMBL2087421,P46663,Bradykinin B1 receptor,1.0,PRIMARY,NO,COc1cc(C)c(c(C)c1)S(=O)(=O)N(C)CCOCC(=O)N2CCN(CC2)C3CCN(C)CC3,36,59,"InChI=1S/C24H40N4O5S/c1-19-16-22(32-5)17-20(2)24(19)34(30,31)26(4)14-15-33-18-23(29)28-12-10-27(11-13-28)21-6-8-25(3)9-7-21/h16-17,21H,6-15,18H2,1-5H3",TYDKAHFZLFMNQX-UHFFFAOYSA-N,"c(""Unchecked"", ""Cyclooxygenase-2"", ""Nitric oxide synthase, inducible"", ""Cyclooxygenase-1"", ""Small conductance calcium-activated potassium channel protein 1"", ""Vasopressin V1a receptor"", ""Vasoactive intestinal polypeptide receptor 1"", ""Bradykinin B1 receptor"", ""Adenosine A1 receptor"", ""Adenosine A2a receptor"", ""Adenosine A3 receptor"", ""Alpha-2c adrenergic receptor"", ""Beta-1 adrenergic receptor"", ""Norepinephrine transporter"", ""Bradykinin B2 receptor"", ""Cannabinoid CB2 receptor"", ""Cholecystokinin B receptor"", ""Dopamine D2 receptor"", ""Histamine H1 receptor"", ""Melanocortin receptor 4"", ""Monoamine oxidase A"", ""Muscarinic acetylcholine receptor M1"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M4"", ""Muscarinic acetylcholine receptor M5"", ""Neurokinin 1 receptor"", ""Neurokinin 3 receptor"", ""Neuropeptide Y receptor type 1"", ""Delta opioid receptor"", ""Mu opioid receptor"", ""Pituitary adenylate cyclase-activating polypeptide type I receptor"", ""Platelet activating factor receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Serotonin 3a (5-HT3a) receptor"", ""Serotonin transporter"")",623,BKRB1,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,GO:0005783 endoplasmic reticulum 9930991 TAS GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 8063797 TAS GO:0043005 neuron projection IEA,IEA GO:0001933 negative regulation of protein phosphorylation IEA GO:0002687 positive regulation of leukocyte migration IEA GO:0006954 inflammatory response 8063797 TAS GO:0007204 positive regulation of cytosolic calcium ion concentration IEA GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA GO:0009612 response to mechanical stimulus IEA GO:0016477 cell migration IEA GO:0019233 sensory perception of pain IEA GO:0030308 negative regulation of cell growth IEA GO:0032496 response to lipopolysaccharide IEA GO:0045776 negative regulation of blood pressure IEA GO:0051281 positive regulation of release of sequestered calcium ion into cytosol,IEA GO:0004947 bradykinin receptor activity 23597562 IPI GO:0005515 protein binding IEA GO:0042277 peptide binding,Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Complement and coagulation cascades - Homo sapiens (human) hsa04610 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04750 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04810 Pathways in cancer - Homo sapiens (human) hsa05200,CHEMBL CHEMBL218427,P30411,Bradykinin B2 receptor,1.0,PRIMARY,NO,Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC4(CCOCC4)C(=O)N5CCN(CC5)C(=O)[C@@H](N)CCC[N+](C)(C)C)c2n1,2,9,"InChI=1S/C36H49Cl2N6O6S/c1-24-22-25(2)40-33-26(24)8-6-10-30(33)50-23-27-28(37)11-12-31(32(27)38)51(47,48)41-36(13-20-49-21-14-36)35(46)43-17-15-42(16-18-43)34(45)29(39)9-7-19-44(3,4)5/h6,8,10-12,22,29,41H,7,9,13-21,23,39H2,1-5H3/q+1/t29-/m0/s1",FQVSDHOWSLEEKJ-LJAQVGFWSA-N,"c(""Bradykinin B2 receptor"", ""Bradykinin B1 receptor"")",624,BKRB2,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,endosome GO:0005768 IDA 17077303 cytosol GO:0005829 IEA plasma membrane GO:0005886 IDA 17077303 plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 TAS 7916737,acute inflammatory response to antigenic stimulus GO:0002438 IEA smooth muscle contraction GO:0006939 17077303 IC inflammatory response GO:0006954 17077303 IC cell surface receptor signaling pathway GO:0007166 7916737 TAS transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 10653985 TAS G-protein coupled receptor signaling pathway GO:0007186 IEA positive regulation of cytosolic calcium ion concentration GO:0007204 IEA blood circulation GO:0008015 7835885 NAS negative regulation of cell proliferation GO:0008285 IEA response to salt stress GO:0009651 IEA regulation of vasoconstriction GO:0019229 17077303 IC negative regulation of peptidyl-serine phosphorylation GO:0033137 IEA maintenance of blood-brain barrier GO:0035633 IEA vasoconstriction GO:0042310 IEA vasodilation GO:0042311 IEA response to drug GO:0042493 IEA regulation of vascular permeability GO:0043114 17077303 IC negative regulation of blood pressure GO:0045776 IEA arachidonic acid secretion GO:0050482 17077303 IDA cellular response to hypoxia GO:0071456 IEA negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator GO:1902239 IEA,protease binding GO:0002020 17077303 IPI phosphatidylinositol phospholipase C activity GO:0004435 8302267 TAS bradykinin receptor activity GO:0004947 17077303 IDA protein binding GO:0005515 18672896 23597562 IPI beta-2 adrenergic receptor binding GO:0031698 IEA type 1 angiotensin receptor binding GO:0031702 10993080 IPI protein heterodimerization activity GO:0046982 10993080 IPI,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04071 Sphingolipid signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04610 Complement and coagulation cascades - Homo sapiens (human) hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human),CHEMBL CHEMBL406291,P30411,Bradykinin B2 receptor,1.0,PRIMARY,YES,N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N2CCC[C@H]2C(=O)NCC(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CO)C(=O)N4CCC[C@H]4C(=O)N[C@@H](Cc5ccccc5)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O,2,26,"InChI=1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1",QXZGBUJJYSLZLT-FDISYFBBSA-N,"c(""Bradykinin B2 receptor"", ""Homo sapiens"", ""Unchecked"", ""Bradykinin B1 receptor"", ""Histone acetyltransferase GCN5"")",624,BKRB2,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,endosome GO:0005768 IDA 17077303 cytosol GO:0005829 IEA plasma membrane GO:0005886 IDA 17077303 plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 TAS 7916737,acute inflammatory response to antigenic stimulus GO:0002438 IEA smooth muscle contraction GO:0006939 17077303 IC inflammatory response GO:0006954 17077303 IC cell surface receptor signaling pathway GO:0007166 7916737 TAS transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 10653985 TAS G-protein coupled receptor signaling pathway GO:0007186 IEA positive regulation of cytosolic calcium ion concentration GO:0007204 IEA blood circulation GO:0008015 7835885 NAS negative regulation of cell proliferation GO:0008285 IEA response to salt stress GO:0009651 IEA regulation of vasoconstriction GO:0019229 17077303 IC negative regulation of peptidyl-serine phosphorylation GO:0033137 IEA maintenance of blood-brain barrier GO:0035633 IEA vasoconstriction GO:0042310 IEA vasodilation GO:0042311 IEA response to drug GO:0042493 IEA regulation of vascular permeability GO:0043114 17077303 IC negative regulation of blood pressure GO:0045776 IEA arachidonic acid secretion GO:0050482 17077303 IDA cellular response to hypoxia GO:0071456 IEA negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator GO:1902239 IEA,protease binding GO:0002020 17077303 IPI phosphatidylinositol phospholipase C activity GO:0004435 8302267 TAS bradykinin receptor activity GO:0004947 17077303 IDA protein binding GO:0005515 18672896 23597562 IPI beta-2 adrenergic receptor binding GO:0031698 IEA type 1 angiotensin receptor binding GO:0031702 10993080 IPI protein heterodimerization activity GO:0046982 10993080 IPI,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04071 Sphingolipid signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04610 Complement and coagulation cascades - Homo sapiens (human) hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human),CHEMBL CHEMBL1170026,Q16581,C3a anaphylatoxin chemotactic receptor,1.0,PRIMARY,NO,CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc3ccc(O)cc3)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CC(C)C)C(=O)N(C)[C@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O,2,3,"InChI=1S/C58H90N14O13S/c1-34(2)30-44(54(81)70(4)35(3)48(75)66-42(57(84)85)17-11-26-63-58(61)62)68-53(80)47-19-13-28-72(47)56(83)41(24-29-86-5)65-52(79)46-18-12-27-71(46)55(82)40(16-9-10-25-59)64-50(77)43(32-36-14-7-6-8-15-36)67-51(78)45(33-73)69-49(76)39(60)31-37-20-22-38(74)23-21-37/h6-8,14-15,20-23,34-35,39-47,73-74H,9-13,16-19,24-33,59-60H2,1-5H3,(H,64,77)(H,65,79)(H,66,75)(H,67,78)(H,68,80)(H,69,76)(H,84,85)(H4,61,62,63)/t35-,39+,40+,41+,42+,43+,44+,45+,46+,47+/m1/s1",KHIZCRHIQGTPIA-RUFGCVQFSA-N,"c(""C3a anaphylatoxin chemotactic receptor"", ""C5a anaphylatoxin chemotactic receptor"")",719,C3AR,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,TAS GO:0005886 plasma membrane TAS 8702752 integral component of plasma membrane GO:0005887,complement receptor mediated signaling pathway GO:0002430 IEA tolerance induction to nonself antigen GO:0002462 IEA chemotaxis GO:0006935 IEA inflammatory response 8765043 GO:0006954 TAS G-protein coupled receptor signaling pathway GO:0007186 IEA positive regulation of cytosolic calcium ion concentration 10571060 GO:0007204 IGI blood circulation 8765043 GO:0008015 TAS regulation of blood pressure GO:0008217 IEA positive regulation of vascular endothelial growth factor production GO:0010575 IEA positive regulation of macrophage chemotaxis GO:0010759 IEA regulation of complement activation GO:0030449 TAS positive regulation of angiogenesis GO:0045766 IEA positive regulation of smooth muscle cell proliferation GO:0048661 IEA positive regulation of glomerular mesangial cell proliferation GO:0072126 IEA positive regulation of neutrophil chemotaxis GO:0090023 IEA positive regulation of DNA biosynthetic process GO:2000573 IEA,complement component C3a binding GO:0001850 IEA phosphatidylinositol phospholipase C activity 8765043 GO:0004435 TAS complement component C3a receptor activity 8765043 GO:0004876 TAS G-protein coupled receptor activity 10571060 GO:0004930 IGI C3a anaphylatoxin receptor activity GO:0004943 IEA,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Complement and coagulation cascades - Homo sapiens (human) hsa04610 Staphylococcus aureus infection - Homo sapiens (human) hsa05150,CHEMBL CHEMBL69715,P07384,Calpain 1,1.0,PRIMARY,NO,NC(=O)C(=O)C(Cc1ccccc1)NC(=O)C2CCN(CC2)C(=O)c3ccc4ccccc4c3,2,3,"InChI=1S/C27H27N3O4/c28-25(32)24(31)23(16-18-6-2-1-3-7-18)29-26(33)20-12-14-30(15-13-20)27(34)22-11-10-19-8-4-5-9-21(19)17-22/h1-11,17,20,23H,12-16H2,(H2,28,32)(H,29,33)",DZIIGLSFYBYZIA-UHFFFAOYSA-N,"c(""Calpain 1"", ""Cathepsin B"", ""Unchecked"")",823,CAN1,Degradation of the extracellular matrix R-HSA-1474228 Extracellular matrix organization R-HSA-1474244,IDA GO:0005737 cytoplasm IEA GO:0005739 mitochondrion IEA GO:0005764 lysosome 12150984 14559243 IDA GO:0005829 cytosol TAS GO:0005829 cytosol 12150984 IDA GO:0005886 plasma membrane 21423176 IDA GO:0005925 focal adhesion 14559243 IDA GO:0016020 membrane 19056867 19199708 23376485 23533145 IDA GO:0070062 extracellular exosome,GO:0006508 proteolysis IBA GO:0006508 proteolysis ISS 8702541 GO:0008284 positive regulation of cell proliferation TAS 17264674 GO:0016241 regulation of macroautophagy NAS GO:0016540 protein autoprocessing IEA GO:0022617 extracellular matrix disassembly TAS GO:0032801 receptor catabolic process IEA GO:0060056 mammary gland involution IEA,GO:0004198 calcium-dependent cysteine-type endopeptidase activity IBA GO:0004198 calcium-dependent cysteine-type endopeptidase activity ISS GO:0005509 calcium ion binding IEA 9407132 19712109 21988832 22805611 GO:0005515 protein binding IPI GO:0008092 cytoskeletal protein binding IEA,"hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) hsa04210 Apoptosis - Homo sapiens (human) hsa05010 Alzheimer,s disease - Homo sapiens (human)",CHEMBL CHEMBL412262,P21554,Cannabinoid CB1 receptor,1.0,ORTHOGONAL,NO,CN\C(=N/S(=O)(=O)c1ccc(Cl)cc1)\N2C[C@@H](C(=N2)c3ccc(Cl)cc3)c4ccccc4,3,25,"InChI=1S/C23H20Cl2N4O2S/c1-26-23(28-32(30,31)20-13-11-19(25)12-14-20)29-15-21(16-5-3-2-4-6-16)22(27-29)17-7-9-18(24)10-8-17/h2-14,21H,15H2,1H3,(H,26,28)/t21-/m1/s1",AXJQVVLKUYCICH-OAQYLSRUSA-N,"c(""Cannabinoid CB1 receptor"", ""Cannabinoid CB2 receptor"", ""P-glycoprotein 1"", ""Unchecked"")",1268,CNR1,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 1718258 TAS axon GO:0030424 IEA growth cone GO:0030426 IEA intracellular membrane-bounded organelle GO:0043231 IEA membrane raft GO:0045121 IEA,"positive regulation of acute inflammatory response to antigenic stimulus IEA GO:0002866 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1718258 GO:0007187 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IDA 18761332 GO:0007188 spermatogenesis IEA GO:0007283 axonal fasciculation IEA GO:0007413 aging IEA GO:0007568 response to nutrient IEA GO:0007584 memory IEA GO:0007613 positive regulation of neuron projection development IEA GO:0010976 sensory perception of pain IEA GO:0019233 positive regulation of fever generation IEA GO:0031622 negative regulation of fatty acid beta-oxidation IEA GO:0031999 regulation of synaptic transmission, GABAergic IEA GO:0032228 response to lipopolysaccharide IEA GO:0032496 negative regulation of mast cell activation IEA GO:0033004 negative regulation of dopamine secretion IEA GO:0033602 response to nicotine IEA GO:0035094 cannabinoid signaling pathway IEA GO:0038171 response to cocaine IEA GO:0042220 glucose homeostasis IEA GO:0042593 positive regulation of apoptotic process IEA GO:0043065 response to morphine IEA GO:0043278 response to ethanol IEA GO:0045471 negative regulation of action potential IEA GO:0045759 negative regulation of blood pressure IEA GO:0045776 positive regulation of blood pressure IEA GO:0045777 regulation of insulin secretion IEA GO:0050796 negative regulation of nitric-oxide synthase activity IEA GO:0051001 regulation of synaptic transmission, glutamatergic IEA GO:0051966 maternal process involved in female pregnancy IEA GO:0060135 regulation of feeding behavior IEA GO:0060259 regulation of penile erection IEA GO:0060405",cannabinoid receptor activity IDA 18761332 GO:0004949 drug binding IEA GO:0008144,Rap1 signaling pathway - Homo sapiens (human) hsa04015 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04723,CHEMBL CHEMBL476833,P21554,Cannabinoid CB1 receptor,1.0,PRIMARY,NO,Cc1c(nn(c2ccc(Cl)cc2Cl)c1c3ccc(I)cc3)C(=O)NN4CCOCC4,5,17,"InChI=1S/C21H19Cl2IN4O2/c1-13-19(21(29)26-27-8-10-30-11-9-27)25-28(18-7-4-15(22)12-17(18)23)20(13)14-2-5-16(24)6-3-14/h2-7,12H,8-11H2,1H3,(H,26,29)",AJFFBPZYXRNAIC-UHFFFAOYSA-N,"c(""Cannabinoid CB1 receptor"", ""Cannabinoid CB2 receptor"", ""Menin/Histone-lysine N-methyltransferase MLL"", ""Lysine-specific demethylase 4D-like"", ""Tyrosyl-DNA phosphodiesterase 1"", ""Microtubule-associated protein tau"", ""Arachidonate 15-lipoxygenase"", ""Unchecked"", ""Regulator of G-protein signaling 4"", ""Ubiquitin carboxyl-terminal hydrolase 1"", ""DNA-(apurinic or apyrimidinic site) lyase"", ""G-protein coupled receptor 55"")",1268,CNR1,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 1718258 TAS axon GO:0030424 IEA growth cone GO:0030426 IEA intracellular membrane-bounded organelle GO:0043231 IEA membrane raft GO:0045121 IEA,"positive regulation of acute inflammatory response to antigenic stimulus IEA GO:0002866 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1718258 GO:0007187 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IDA 18761332 GO:0007188 spermatogenesis IEA GO:0007283 axonal fasciculation IEA GO:0007413 aging IEA GO:0007568 response to nutrient IEA GO:0007584 memory IEA GO:0007613 positive regulation of neuron projection development IEA GO:0010976 sensory perception of pain IEA GO:0019233 positive regulation of fever generation IEA GO:0031622 negative regulation of fatty acid beta-oxidation IEA GO:0031999 regulation of synaptic transmission, GABAergic IEA GO:0032228 response to lipopolysaccharide IEA GO:0032496 negative regulation of mast cell activation IEA GO:0033004 negative regulation of dopamine secretion IEA GO:0033602 response to nicotine IEA GO:0035094 cannabinoid signaling pathway IEA GO:0038171 response to cocaine IEA GO:0042220 glucose homeostasis IEA GO:0042593 positive regulation of apoptotic process IEA GO:0043065 response to morphine IEA GO:0043278 response to ethanol IEA GO:0045471 negative regulation of action potential IEA GO:0045759 negative regulation of blood pressure IEA GO:0045776 positive regulation of blood pressure IEA GO:0045777 regulation of insulin secretion IEA GO:0050796 negative regulation of nitric-oxide synthase activity IEA GO:0051001 regulation of synaptic transmission, glutamatergic IEA GO:0051966 maternal process involved in female pregnancy IEA GO:0060135 regulation of feeding behavior IEA GO:0060259 regulation of penile erection IEA GO:0060405",cannabinoid receptor activity IDA 18761332 GO:0004949 drug binding IEA GO:0008144,Rap1 signaling pathway - Homo sapiens (human) hsa04015 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04723,CHEMBL CHEMBL285932,P21554,Cannabinoid CB1 receptor,1.0,PRIMARY,YES,Cc1c(nn(c2ccc(Cl)cc2Cl)c1c3ccc(I)cc3)C(=O)NN4CCCCC4,4,47,"InChI=1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)",BUZAJRPLUGXRAB-UHFFFAOYSA-N,"c(""Cannabinoid receptor"", ""Vanilloid receptor"", ""Cannabinoid CB1 receptor"", ""Cannabinoid CB2 receptor"", ""Unchecked"", ""Prelamin-A/C"", ""microRNA 21"", ""Microtubule-associated protein tau"", ""Neuropeptide S receptor"", ""Histone-lysine N-methyltransferase, H3 lysine-9 specific 3"", ""Bromodomain adjacent to zinc finger domain protein 2B"", ""Regulator of G-protein signaling 4"", ""G-protein coupled receptor 55"")",1268,CNR1,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 1718258 TAS axon GO:0030424 IEA growth cone GO:0030426 IEA intracellular membrane-bounded organelle GO:0043231 IEA membrane raft GO:0045121 IEA,"positive regulation of acute inflammatory response to antigenic stimulus IEA GO:0002866 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1718258 GO:0007187 adenylate cyclase-modulating G-protein coupled receptor signaling pathway IDA 18761332 GO:0007188 spermatogenesis IEA GO:0007283 axonal fasciculation IEA GO:0007413 aging IEA GO:0007568 response to nutrient IEA GO:0007584 memory IEA GO:0007613 positive regulation of neuron projection development IEA GO:0010976 sensory perception of pain IEA GO:0019233 positive regulation of fever generation IEA GO:0031622 negative regulation of fatty acid beta-oxidation IEA GO:0031999 regulation of synaptic transmission, GABAergic IEA GO:0032228 response to lipopolysaccharide IEA GO:0032496 negative regulation of mast cell activation IEA GO:0033004 negative regulation of dopamine secretion IEA GO:0033602 response to nicotine IEA GO:0035094 cannabinoid signaling pathway IEA GO:0038171 response to cocaine IEA GO:0042220 glucose homeostasis IEA GO:0042593 positive regulation of apoptotic process IEA GO:0043065 response to morphine IEA GO:0043278 response to ethanol IEA GO:0045471 negative regulation of action potential IEA GO:0045759 negative regulation of blood pressure IEA GO:0045776 positive regulation of blood pressure IEA GO:0045777 regulation of insulin secretion IEA GO:0050796 negative regulation of nitric-oxide synthase activity IEA GO:0051001 regulation of synaptic transmission, glutamatergic IEA GO:0051966 maternal process involved in female pregnancy IEA GO:0060135 regulation of feeding behavior IEA GO:0060259 regulation of penile erection IEA GO:0060405",cannabinoid receptor activity IDA 18761332 GO:0004949 drug binding IEA GO:0008144,Rap1 signaling pathway - Homo sapiens (human) hsa04015 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04723,CHEMBL CHEMBL468176,P34972,Cannabinoid CB2 receptor,1.0,PRIMARY,YES,Fc1ccc(c(Cl)c1)c2noc(n2)C3CCN(CC3)c4cnc5ccc(Cl)cc5c4,11,32,"InChI=1S/C22H17Cl2FN4O/c23-15-1-4-20-14(9-15)10-17(12-26-20)29-7-5-13(6-8-29)22-27-21(28-30-22)18-3-2-16(25)11-19(18)24/h1-4,9-13H,5-8H2",KZPYBMNBUZPMKP-UHFFFAOYSA-N,"c(""Cannabinoid CB2 receptor"", ""Cannabinoid CB1 receptor"", ""Somatostatin receptor 4"", ""Unchecked"", ""Beta-1 adrenergic receptor"", ""Dopamine D2 receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 2b (5-HT2b) receptor"", ""Neurokinin 1 receptor"", ""Mu opioid receptor"", ""Histamine H1 receptor"", ""Muscarinic acetylcholine receptor M1"")",1269,CNR2,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,plasma membrane GO:0005886 TAS integral component of plasma membrane 8679694 GO:0005887 TAS dendrite GO:0030425 IEA extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IEA perikaryon GO:0043204 IEA,"GO:0001975 response to amphetamine IEA GO:0006954 inflammatory response IEA GO:0006955 immune response 7556170 TAS GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 8679694 TAS GO:0019233 sensory perception of pain IEA GO:0032229 negative regulation of synaptic transmission, GABAergic IEA GO:0032496 response to lipopolysaccharide IEA GO:0033004 negative regulation of mast cell activation IEA GO:0038171 cannabinoid signaling pathway IEA GO:0045759 negative regulation of action potential IEA GO:0050728 negative regulation of inflammatory response IEA GO:0051001 negative regulation of nitric-oxide synthase activity IEA",cannabinoid receptor activity GO:0004949 IEA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL2062577,P68400,Casein kinase II alpha,1.0,PRIMARY,NO,CN(C(=O)C)c1ccc2ccn(c3cc(NC4CC4)n5ncc(C#N)c5n3)c2c1,4,8,"InChI=1S/C21H19N7O/c1-13(29)26(2)17-6-3-14-7-8-27(18(14)9-17)19-10-20(24-16-4-5-16)28-21(25-19)15(11-22)12-23-28/h3,6-10,12,16,24H,4-5H2,1-2H3",LEBFBYRNCKITGV-UHFFFAOYSA-N,"c(""Casein kinase II alpha"", ""Glycogen synthase kinase-3 beta"", ""Homeodomain-interacting protein kinase 2"", ""Unchecked"", ""Cyclin-dependent kinase 2"")",1457,CSK21,"R-HSA-1266738 Developmental Biology R-HSA-162582 Signal Transduction R-HSA-1640170 Cell Cycle R-HSA-195721 Signaling by Wnt R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-201688 WNT mediated activation of DVL R-HSA-2514853 Condensation of Prometaphase Chromosomes R-HSA-373760 L1CAM interactions R-HSA-422475 Axon guidance R-HSA-445144 Signal transduction by L1 R-HSA-68877 Mitotic Prometaphase R-HSA-68886 M Phase R-HSA-69278 Cell Cycle, Mitotic",nucleus IDA 21282530 21630459 GO:0005634 nucleoplasm TAS GO:0005654 cytosol TAS GO:0005829 plasma membrane TAS 10799509 GO:0005886 Sin3 complex IDA 17827154 GO:0016580 NuRD complex IDA 17827154 GO:0016581 colocalizes_with PcG protein complex IDA 21282530 GO:0031519,"IEA GO:0006351 transcription, DNA-templated IEA GO:0006355 regulation of transcription, DNA-templated TAS GO:0006457 protein folding IDA 20625391 22406621 protein phosphorylation GO:0006468 TAS 2174700 signal transduction GO:0007165 IDA 20625391 positive regulation of cell proliferation GO:0008284 IEA GO:0016055 Wnt signaling pathway IMP 12700239 positive regulation of Wnt signaling pathway GO:0030177 IDA 20625391 positive regulation of cell growth GO:0030307 IMP 16193064 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IDA 20625391 positive regulation of protein catabolic process GO:0045732 IEA GO:0046777 protein autophosphorylation IEA GO:0048511 rhythmic process IEA GO:0050790 regulation of catalytic activity TAS 19387550 chaperone-mediated protein folding GO:0061077 IMP 11704824 mitotic spindle checkpoint GO:0071174 TAS GO:1901796 regulation of signal transduction by p53 class mediator",12700239 16193064 20625391 20864032 IDA GO:0004674 protein serine/threonine kinase activity 11035045 IMP GO:0004674 protein serine/threonine kinase activity 2174700 TAS GO:0004674 protein serine/threonine kinase activity 10094392 11574463 12191471 12769847 14667819 16873060 19011756 19236849 19680552 20625391 21282530 21516116 21968188 21988832 22113938 22317921 22406621 22975381 23455922 23555304 23752268 24535599 25241761 25416956 25852190 26711270 IPI GO:0005515 protein binding IEA GO:0005524 ATP binding IEA GO:0008013 beta-catenin binding IEA GO:0019888 protein phosphatase regulator activity 11972058 IPI GO:0047485 protein N-terminus binding 19387550 TAS GO:0051879 Hsp90 protein binding,Ribosome biogenesis in eukaryotes - Homo sapiens (human) hsa03008 NF-kappa B signaling pathway - Homo sapiens (human) hsa04064 Wnt signaling pathway - Homo sapiens (human) hsa04310 Adherens junction - Homo sapiens (human) hsa04520 Tight junction - Homo sapiens (human) hsa04530 Measles - Homo sapiens (human) hsa05162 Herpes simplex infection - Homo sapiens (human) hsa05168 Epstein-Barr virus infection - Homo sapiens (human) hsa05169,CHEMBL CHEMBL249915,P25774,Cathepsin S,1.0,ORTHOGONAL,NO,CS(=O)(=O)C[C@H](N[C@@H](c1ccc(F)cc1)C(F)(F)F)C(=O)NC2(CC2)C#N,4,8,"InChI=1S/C16H17F4N3O3S/c1-27(25,26)8-12(14(24)23-15(9-21)6-7-15)22-13(16(18,19)20)10-2-4-11(17)5-3-10/h2-5,12-13,22H,6-8H2,1H3,(H,23,24)/t12-,13-/m0/s1",HBOZUMOKFHNMQI-STQMWFEESA-N,"c(""Cathepsin S"", ""Cathepsin K"", ""Cathepsin B"", ""Cathepsin L"", ""Unchecked"")",1520,CATS,R-HSA-1236975 Antigen processing-Cross presentation R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-1280218 Adaptive Immune System R-HSA-1474228 Degradation of the extracellular matrix R-HSA-1474244 Extracellular matrix organization R-HSA-1474290 Collagen formation R-HSA-1679131 Trafficking and processing of endosomal TLR R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-168898 Toll-Like Receptors Cascades R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures R-HSA-2132295 MHC class II antigen presentation R-HSA-983169 Class I MHC mediated antigen processing & presentation,14718574 GO:0005576 extracellular region NAS GO:0005576 extracellular region TAS 16502470 22952693 GO:0005615 extracellular space IDA 15196205 GO:0005764 lysosome IDA GO:0036021 endolysosome lumen TAS GO:0043202 lysosomal lumen TAS GO:0043231 intracellular membrane-bounded organelle IDA,TAS GO:0002224 toll-like receptor signaling pathway IEP 15196205 adaptive immune response GO:0002250 IDA 22864553 proteolysis GO:0006508 TAS 8157683 immune response GO:0006955 IDA 22864553 response to acidic pH GO:0010447 IDA 22864553 protein processing GO:0016485 TAS 15196205 antigen processing and presentation GO:0019882 TAS GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS GO:0022617 extracellular matrix disassembly IDA 22952693 collagen catabolic process GO:0030574 IDA 22952693 basement membrane disassembly GO:0034769 IDA 8612130 antigen processing and presentation of peptide antigen GO:0048002 IDA 22952693 proteolysis involved in cellular protein catabolic process GO:0051603 IEP 21217776 cellular response to thyroid hormone stimulus GO:0097067 IDA 22864553 positive regulation of cation channel activity GO:2001259,IPI 22952693 fibronectin binding GO:0001968 IDA 8612130 22952693 cysteine-type endopeptidase activity GO:0004197 TAS GO:0004197 cysteine-type endopeptidase activity TAS GO:0004252 serine-type endopeptidase activity IDA 22952693 collagen binding GO:0005518 IDA 22952693 laminin binding GO:0043236 IPI 22952693 proteoglycan binding GO:0043394,Lysosome - Homo sapiens (human) hsa04142 Phagosome - Homo sapiens (human) hsa04145 Antigen processing and presentation - Homo sapiens (human) hsa04612 Tuberculosis - Homo sapiens (human) hsa05152,CHEMBL CHEMBL1209145,P25774,Cathepsin S,1.0,PRIMARY,NO,CCN1CCN(CCCOc2ccc(cc2C(F)(F)F)c3cc4c(ncn4C)c(n3)C#N)CC1,5,9,"InChI=1S/C24H27F3N6O/c1-3-32-8-10-33(11-9-32)7-4-12-34-22-6-5-17(13-18(22)24(25,26)27)19-14-21-23(20(15-28)30-19)29-16-31(21)2/h5-6,13-14,16H,3-4,7-12H2,1-2H3",WRILSUPEKWTWKI-UHFFFAOYSA-N,"c(""Cathepsin K"", ""Cathepsin S"", ""Cathepsin B"", ""Cathepsin L2"", ""Cathepsin L"")",1520,CATS,R-HSA-1236975 Antigen processing-Cross presentation R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-1280218 Adaptive Immune System R-HSA-1474228 Degradation of the extracellular matrix R-HSA-1474244 Extracellular matrix organization R-HSA-1474290 Collagen formation R-HSA-1679131 Trafficking and processing of endosomal TLR R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-168898 Toll-Like Receptors Cascades R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures R-HSA-2132295 MHC class II antigen presentation R-HSA-983169 Class I MHC mediated antigen processing & presentation,14718574 GO:0005576 extracellular region NAS GO:0005576 extracellular region TAS 16502470 22952693 GO:0005615 extracellular space IDA 15196205 GO:0005764 lysosome IDA GO:0036021 endolysosome lumen TAS GO:0043202 lysosomal lumen TAS GO:0043231 intracellular membrane-bounded organelle IDA,TAS GO:0002224 toll-like receptor signaling pathway IEP 15196205 adaptive immune response GO:0002250 IDA 22864553 proteolysis GO:0006508 TAS 8157683 immune response GO:0006955 IDA 22864553 response to acidic pH GO:0010447 IDA 22864553 protein processing GO:0016485 TAS 15196205 antigen processing and presentation GO:0019882 TAS GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS GO:0022617 extracellular matrix disassembly IDA 22952693 collagen catabolic process GO:0030574 IDA 22952693 basement membrane disassembly GO:0034769 IDA 8612130 antigen processing and presentation of peptide antigen GO:0048002 IDA 22952693 proteolysis involved in cellular protein catabolic process GO:0051603 IEP 21217776 cellular response to thyroid hormone stimulus GO:0097067 IDA 22864553 positive regulation of cation channel activity GO:2001259,IPI 22952693 fibronectin binding GO:0001968 IDA 8612130 22952693 cysteine-type endopeptidase activity GO:0004197 TAS GO:0004197 cysteine-type endopeptidase activity TAS GO:0004252 serine-type endopeptidase activity IDA 22952693 collagen binding GO:0005518 IDA 22952693 laminin binding GO:0043236 IPI 22952693 proteoglycan binding GO:0043394,Lysosome - Homo sapiens (human) hsa04142 Phagosome - Homo sapiens (human) hsa04145 Antigen processing and presentation - Homo sapiens (human) hsa04612 Tuberculosis - Homo sapiens (human) hsa05152,CHEMBL CHEMBL2180528,P32246,C-C chemokine receptor type 1,1.0,PRIMARY,NO,CC(C)[C@@H](NC(=O)c1ccccc1)C(=O)N2CCC(CC2)c3ccc(Cl)cc3,4,9,"InChI=1S/C23H27ClN2O2/c1-16(2)21(25-22(27)19-6-4-3-5-7-19)23(28)26-14-12-18(13-15-26)17-8-10-20(24)11-9-17/h3-11,16,18,21H,12-15H2,1-2H3,(H,25,27)/t21-/m1/s1",TYQNFWIJWOXJPV-OAQYLSRUSA-N,"c(""C-C chemokine receptor type 5"", ""C-C chemokine receptor type 3"", ""C-C chemokine receptor type 2"", ""C-C chemokine receptor type 1"")",1230,CCR1,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-380108 Chemokine receptors bind chemokines R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,plasma membrane IDA 10660125 15474493 18587271 GO:0005886 plasma membrane IMP 15001559 GO:0005886 plasma membrane TAS GO:0005886 integral component of plasma membrane TAS 7505609 GO:0005887 external side of plasma membrane IDA 10706735 GO:0009897,"16621978 TAS GO:0002407 dendritic cell chemotaxis 10734056 IDA GO:0006816 calcium ion transport 10734056 IDA GO:0006874 cellular calcium ion homeostasis 10734056 IDA GO:0006887 exocytosis 15474493 NAS GO:0006935 chemotaxis IEA GO:0006954 inflammatory response 10734056 IDA GO:0006955 immune response 10910894 TAS GO:0007155 cell adhesion 10770925 TAS GO:0007166 cell surface receptor signaling pathway 7505609 TAS GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 10734056 IDA GO:0007204 positive regulation of cytosolic calcium ion concentration 10734056 IDA GO:0007267 cell-cell signaling 7505609 TAS GO:0009611 response to wounding 21403648 IMP GO:0010629 negative regulation of gene expression 15474493 NAS GO:0019221 cytokine-mediated signaling pathway 24056371 IMP GO:0030335 positive regulation of cell migration 21403648 IMP GO:0030502 negative regulation of bone mineralization 21403648 IMP GO:0045672 positive regulation of osteoclast differentiation 15764707 IDA GO:0051928 positive regulation of calcium ion transport 21403648 IDA GO:0070098 chemokine-mediated signaling pathway 21403648 IMP GO:0070374 positive regulation of ERK1 and ERK2 cascade 18587271 IDA GO:0090026 positive regulation of monocyte chemotaxis",phosphatidylinositol phospholipase C activity GO:0004435 10734056 IDA chemokine receptor activity GO:0004950 10660125 IDA protein binding GO:0005515 8699119 15001559 15474493 IPI C-C chemokine receptor activity GO:0016493 10734056 IDA C-C chemokine binding GO:0019957 7545673 8699119 10660125 15764707 IPI chemokine (C-C motif) ligand 7 binding GO:0035717 7545673 10660125 IPI chemokine (C-C motif) ligand 5 binding GO:0071791 7545673 8699119 10660125 10734056 IPI,hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human),CHEMBL CHEMBL250689,P51677,C-C chemokine receptor type 3,1.0,PRIMARY,NO,CC(=O)c1cccc(NC(=O)N[C@@H]2CCCC[C@H]2CN3CCC[C@@H](Cc4ccc(F)cc4)C3)c1,11,32,"InChI=1S/C28H36FN3O2/c1-20(33)23-8-4-9-26(17-23)30-28(34)31-27-10-3-2-7-24(27)19-32-15-5-6-22(18-32)16-21-11-13-25(29)14-12-21/h4,8-9,11-14,17,22,24,27H,2-3,5-7,10,15-16,18-19H2,1H3,(H2,30,31,34)/t22-,24-,27+/m0/s1",ASRDPULQBHFPGU-WFIHMLKPSA-N,"c(""C-C chemokine receptor type 3"", ""Interleukin-8 receptor A"", ""Interleukin-8 receptor B"", ""Unchecked"", ""C-C chemokine receptor type 1"", ""C-C chemokine receptor type 2"", ""C-C chemokine receptor type 5"", ""Serotonin 2a (5-HT2a) receptor"", ""Dopamine D2 receptor"", ""Serotonin transporter"", ""Dopamine transporter"", ""Norepinephrine transporter"")",1232,CCR3,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 Chemokine receptors bind chemokines R-HSA-380108 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 9302298 TAS,positive regulation of endothelial cell proliferation GO:0001938 IEA chemotaxis GO:0006935 IEA inflammatory response GO:0006954 IEA cellular defense response 10713092 GO:0006968 TAS cell adhesion 10201960 GO:0007155 TAS adenylate cyclase-modulating G-protein coupled receptor signaling pathway 10201960 GO:0007188 TAS positive regulation of cytosolic calcium ion concentration 9302298 GO:0007204 TAS viral process GO:0016032 IEA positive regulation of angiogenesis 19525930 GO:0045766 IMP chemokine-mediated signaling pathway GO:0070098 IEA,chemokine receptor activity 10415069 GO:0004950 TAS protein binding 23597562 GO:0005515 IPI C-C chemokine receptor activity GO:0016493 IEA,hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human),CHEMBL CHEMBL1078231,P51681,C-C chemokine receptor type 5,1.0,ORTHOGONAL,NO,CCCC[C@H]1CN(CC2CCOCC2)C(=O)OC13CCN(CC3)C4(C)CCN(CC4)C(=O)c5c(C)ncnc5C,7,11,"InChI=1S/C31H49N5O4/c1-5-6-7-26-21-35(20-25-8-18-39-19-9-25)29(38)40-31(26)12-16-36(17-13-31)30(4)10-14-34(15-11-30)28(37)27-23(2)32-22-33-24(27)3/h22,25-26H,5-21H2,1-4H3/t26-/m0/s1",CXXVJZRGOOIVOD-SANMLTNESA-N,"c(""C-C chemokine receptor type 5"", ""C-C chemokine receptor type 1"", ""C-C chemokine receptor type 2"", ""C-C chemokine receptor type 3"", ""C-C chemokine receptor type 4"", ""C-C chemokine receptor type 6"", ""C-X-C chemokine receptor type 4"", ""Unchecked"")",1234,CCR5,R-HSA-162582 Signal Transduction R-HSA-162587 HIV Life Cycle R-HSA-162594 Early Phase of HIV Life Cycle R-HSA-162906 HIV Infection R-HSA-1643685 Disease R-HSA-173107 Binding and entry of HIV virion R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-380108 Chemokine receptors bind chemokines R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding R-HSA-5663205 Infectious disease,cytoplasm GO:0005737 TAS 10415069 endosome GO:0005768 IDA 10679098 plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 TAS 10393923 external side of plasma membrane GO:0009897 IDA 10679098 11278962 19523456 cell surface GO:0009986 IDA 10521508,12032188 GO:0000165 MAPK cascade IEP 16621978 GO:0002407 dendritic cell chemotaxis TAS 8699119 GO:0006816 calcium ion transport IDA 10741397 GO:0006935 chemotaxis TAS GO:0006954 inflammatory response IEA GO:0006955 immune response IEA 10201901 GO:0006968 cellular defense response TAS 8639485 GO:0007166 cell surface receptor signaling pathway TAS 19523456 GO:0007186 G-protein coupled receptor signaling pathway IMP 10201901 GO:0007204 positive regulation of cytosolic calcium ion concentration TAS 10679098 GO:0007267 cell-cell signaling IDA 19523456 GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA GO:0019064 fusion of virus membrane with host plasma membrane TAS 10679098 19523456 GO:0019722 calcium-mediated signaling IDA 12032188 GO:0023052 signaling IEP GO:0030260 entry into host cell TAS GO:0070098 chemokine-mediated signaling pathway IEA 19523456 GO:0070723 response to cholesterol IMP 10679098 GO:0071222 cellular response to lipopolysaccharide IEP,GO:0001618 virus receptor activity IEA 12421915 GO:0003779 actin binding IDA 8663314 GO:0004435 phosphatidylinositol phospholipase C activity TAS 10201901 GO:0004950 chemokine receptor activity TAS 10816381 12421915 15001559 15660419 23480650 23597562 24405750 GO:0005515 protein binding IPI 10469138 GO:0015026 coreceptor activity TAS 11278962 GO:0016493 C-C chemokine receptor activity IDA 8639485 GO:0016493 C-C chemokine receptor activity NAS 8699119 10679098 GO:0019957 C-C chemokine binding IPI 8699119 GO:0071791 chemokine (C-C motif) ligand 5 binding IPI,Cytokine-cytokine receptor interaction - Homo sapiens (human) hsa04060 Chemokine signaling pathway - Homo sapiens (human) hsa04062 Endocytosis - Homo sapiens (human) hsa04144 Toxoplasmosis - Homo sapiens (human) hsa05145 Viral carcinogenesis - Homo sapiens (human) hsa05203,CHEMBL CHEMBL212689,P51681,C-C chemokine receptor type 5,1.0,PRIMARY,NO,CCN(C1CCN(CC[C@H](c2ccc(cc2)S(=O)(=O)C)c3cc(F)cc(F)c3)CC1)C(=O)Cc4ccc(cc4)S(=O)(=O)C,9,15,"InChI=1S/C32H38F2N2O5S2/c1-4-36(32(37)19-23-5-9-29(10-6-23)42(2,38)39)28-13-16-35(17-14-28)18-15-31(25-20-26(33)22-27(34)21-25)24-7-11-30(12-8-24)43(3,40)41/h5-12,20-22,28,31H,4,13-19H2,1-3H3/t31-/m1/s1",SCXSQUUTGCWHFU-WJOKGBTCSA-N,"c(""Serotonin 2a (5-HT2a) receptor"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M1"", ""Interleukin-8 receptor B"", ""Interleukin-8 receptor A"", ""C-C chemokine receptor type 3"", ""C-C chemokine receptor type 2"", ""C-C chemokine receptor type 1"", ""T-cells"", ""C-C chemokine receptor type 5"", ""Unchecked"")",1234,CCR5,R-HSA-162582 Signal Transduction R-HSA-162587 HIV Life Cycle R-HSA-162594 Early Phase of HIV Life Cycle R-HSA-162906 HIV Infection R-HSA-1643685 Disease R-HSA-173107 Binding and entry of HIV virion R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-380108 Chemokine receptors bind chemokines R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding R-HSA-5663205 Infectious disease,cytoplasm GO:0005737 TAS 10415069 endosome GO:0005768 IDA 10679098 plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 TAS 10393923 external side of plasma membrane GO:0009897 IDA 10679098 11278962 19523456 cell surface GO:0009986 IDA 10521508,12032188 GO:0000165 MAPK cascade IEP 16621978 GO:0002407 dendritic cell chemotaxis TAS 8699119 GO:0006816 calcium ion transport IDA 10741397 GO:0006935 chemotaxis TAS GO:0006954 inflammatory response IEA GO:0006955 immune response IEA 10201901 GO:0006968 cellular defense response TAS 8639485 GO:0007166 cell surface receptor signaling pathway TAS 19523456 GO:0007186 G-protein coupled receptor signaling pathway IMP 10201901 GO:0007204 positive regulation of cytosolic calcium ion concentration TAS 10679098 GO:0007267 cell-cell signaling IDA 19523456 GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA GO:0019064 fusion of virus membrane with host plasma membrane TAS 10679098 19523456 GO:0019722 calcium-mediated signaling IDA 12032188 GO:0023052 signaling IEP GO:0030260 entry into host cell TAS GO:0070098 chemokine-mediated signaling pathway IEA 19523456 GO:0070723 response to cholesterol IMP 10679098 GO:0071222 cellular response to lipopolysaccharide IEP,GO:0001618 virus receptor activity IEA 12421915 GO:0003779 actin binding IDA 8663314 GO:0004435 phosphatidylinositol phospholipase C activity TAS 10201901 GO:0004950 chemokine receptor activity TAS 10816381 12421915 15001559 15660419 23480650 23597562 24405750 GO:0005515 protein binding IPI 10469138 GO:0015026 coreceptor activity TAS 11278962 GO:0016493 C-C chemokine receptor activity IDA 8639485 GO:0016493 C-C chemokine receptor activity NAS 8699119 10679098 GO:0019957 C-C chemokine binding IPI 8699119 GO:0071791 chemokine (C-C motif) ligand 5 binding IPI,Cytokine-cytokine receptor interaction - Homo sapiens (human) hsa04060 Chemokine signaling pathway - Homo sapiens (human) hsa04062 Endocytosis - Homo sapiens (human) hsa04144 Toxoplasmosis - Homo sapiens (human) hsa05145 Viral carcinogenesis - Homo sapiens (human) hsa05203,CHEMBL CHEMBL380492,P51685,C-C chemokine receptor type 8,1.0,ORTHOGONAL,NO,CC(C)(N1CCC(CC1)(C(=O)NC2CCN(Cc3cccc(Oc4ccccc4Cl)c3)CC2)c5ccccc5)C(=O)O,6,8,"InChI=1S/C34H40ClN3O4/c1-33(2,32(40)41)38-21-17-34(18-22-38,26-10-4-3-5-11-26)31(39)36-27-15-19-37(20-16-27)24-25-9-8-12-28(23-25)42-30-14-7-6-13-29(30)35/h3-14,23,27H,15-22,24H2,1-2H3,(H,36,39)(H,40,41)",TXEFMFGXKKPZEW-UHFFFAOYSA-N,"c(""C-C chemokine receptor type 8"", ""C-C chemokine receptor type 3"", ""Serotonin 2a (5-HT2a) receptor"", ""Beta-1 adrenergic receptor"", ""Beta-2 adrenergic receptor"", ""Dopamine D2 receptor"", ""Unchecked"")",1237,CCR8,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 Chemokine receptors bind chemokines R-HSA-380108 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,TAS GO:0005886 plasma membrane TAS 8816377 integral component of plasma membrane GO:0005887,chemotaxis IEA GO:0006935 immune response IEA GO:0006955 cell adhesion TAS 10910894 GO:0007155 G-protein coupled receptor signaling pathway IEA GO:0007186 positive regulation of cytosolic calcium ion concentration IEA GO:0007204 chemokine-mediated signaling pathway IEA GO:0070098,chemokine receptor activity TAS 9417093 GO:0004950 coreceptor activity TAS 9417093 GO:0015026 C-C chemokine receptor activity IEA GO:0016493,hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human),CHEMBL CHEMBL218375,P51685,C-C chemokine receptor type 8,1.0,PRIMARY,NO,CCOC(=O)N1CCC(CC1)NS(=O)(=O)c2ccc(NC(=O)c3ccccc3C)c4ccccc24,6,10,"InChI=1S/C26H29N3O5S/c1-3-34-26(31)29-16-14-19(15-17-29)28-35(32,33)24-13-12-23(21-10-6-7-11-22(21)24)27-25(30)20-9-5-4-8-18(20)2/h4-13,19,28H,3,14-17H2,1-2H3,(H,27,30)",LGJRRERRFSZFTJ-UHFFFAOYSA-N,"c(""C-C chemokine receptor type 8"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Beta-1 adrenergic receptor"", ""Beta-2 adrenergic receptor"", ""Unchecked"", ""Muscarinic acetylcholine receptor"", ""Serotonin 2a (5-HT2a) receptor"")",1237,CCR8,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 Chemokine receptors bind chemokines R-HSA-380108 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,TAS GO:0005886 plasma membrane TAS 8816377 integral component of plasma membrane GO:0005887,chemotaxis IEA GO:0006935 immune response IEA GO:0006955 cell adhesion TAS 10910894 GO:0007155 G-protein coupled receptor signaling pathway IEA GO:0007186 positive regulation of cytosolic calcium ion concentration IEA GO:0007204 chemokine-mediated signaling pathway IEA GO:0070098,chemokine receptor activity TAS 9417093 GO:0004950 coreceptor activity TAS 9417093 GO:0015026 C-C chemokine receptor activity IEA GO:0016493,hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human),CHEMBL CHEMBL2348154,O00311,Cell division cycle 7-related protein kinase,1.0,PRIMARY,NO,Nc1nccc(n1)n2cc(c3cccnc3Cl)c4cnccc24,2,4,"InChI=1S/C16H11ClN6/c17-15-10(2-1-5-20-15)12-9-23(13-3-6-19-8-11(12)13)14-4-7-21-16(18)22-14/h1-9H,(H2,18,21,22)",CCCPUPRKQZVNNE-UHFFFAOYSA-N,"c(""Cell division cycle 7-related protein kinase"", ""Unchecked"", ""Cyclin-dependent kinase 2"")",8317,CDC7,"Cell Cycle R-HSA-1640170 Activation of ATR in response to replication stress R-HSA-176187 Mitotic G1-G1/S phases R-HSA-453279 M/G1 Transition R-HSA-68874 Activation of the pre-replicative complex R-HSA-68962 DNA Replication Pre-Initiation R-HSA-69002 G1/S Transition R-HSA-69206 Cell Cycle, Mitotic R-HSA-69278 DNA Replication R-HSA-69306 G2/M Checkpoints R-HSA-69481 Cell Cycle Checkpoints R-HSA-69620",9250678 IDA GO:0005634 nucleus IDA GO:0005654 nucleoplasm TAS GO:0005654 nucleoplasm 9250678 IDA GO:0005737 cytoplasm IDA GO:0015630 microtubule cytoskeleton IDA GO:0045171 intercellular bridge,GO:0000082 G1/S transition of mitotic cell cycle TAS GO:0000727 double-strand break repair via break-induced replication IBA GO:0006260 DNA replication TAS GO:0006270 DNA replication initiation IBA GO:0006909 phagocytosis IBA GO:0008284 positive regulation of cell proliferation 17102137 IMP GO:0008360 regulation of cell shape IBA GO:0010571 positive regulation of nuclear cell cycle DNA replication 15668232 IMP GO:0010971 positive regulation of G2/M transition of mitotic cell cycle 15668232 IMP GO:0018105 peptidyl-serine phosphorylation IBA GO:0044770 cell cycle phase transition 17102137 IMP GO:0051301 cell division IEA,GO:0004672 protein kinase activity 12065429 15668232 IMP GO:0004674 protein serine/threonine kinase activity IBA GO:0005515 protein binding 12065429 15668232 22540012 24299456 IPI GO:0005524 ATP binding IEA GO:0016301 kinase activity 9250678 IDA GO:0046872 metal ion binding IEA,Cell cycle - Homo sapiens (human) hsa04110,CHEMBL CHEMBL1933104,P32238,Cholecystokinin A receptor,1.0,ORTHOGONAL,NO,OC(=O)[C@@H](CCc1ccccc1)NC(=O)c2ccccc2NC(=O)c3cc4ccccc4[nH]3,2,25,"InChI=1S/C26H23N3O4/c30-24(29-22(26(32)33)15-14-17-8-2-1-3-9-17)19-11-5-7-13-21(19)28-25(31)23-16-18-10-4-6-12-20(18)27-23/h1-13,16,22,27H,14-15H2,(H,28,31)(H,29,30)(H,32,33)/t22-/m1/s1",XLWHWNHGNRPPBH-JOCHJYFZSA-N,"c(""Unchecked"", ""Cholecystokinin A receptor"", ""Cholecystokinin B receptor"")",886,CCKAR,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,lysosome GO:0005764 IEA endosome GO:0005768 IEA endoplasmic reticulum GO:0005783 IEA cytosol GO:0005829 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 8343165 TAS terminal bouton GO:0043195 IEA,temperature homeostasis GO:0001659 IEA gastric acid secretion GO:0001696 IEA neuron migration GO:0001764 IEA reduction of food intake in response to dietary excess GO:0002023 IEA phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 TAS 8343165 positive regulation of cytosolic calcium ion concentration GO:0007204 IEA axonogenesis GO:0007409 IEA response to nutrient GO:0007584 IEA digestion GO:0007586 TAS 8503909 feeding behavior GO:0007631 TAS 8503909 response to radiation GO:0009314 IEA response to heat GO:0009408 IEA insulin secretion GO:0030073 IEA pancreatic juice secretion GO:0030157 IEA forebrain development GO:0030900 IEA pancreas development GO:0031016 IEA organ regeneration GO:0031100 IEA actin cytoskeleton reorganization GO:0031532 IEA response to lipopolysaccharide GO:0032496 IEA cellular response to hormone stimulus GO:0032870 IEA cholecystokinin signaling pathway GO:0038188 IEA response to starvation GO:0042594 IEA regulation of potassium ion transport GO:0043266 IEA regulation of hormone secretion GO:0046883 IBA response to glucocorticoid GO:0051384 IEA regulation of calcium ion transport GO:0051924 IEA positive regulation of somatostatin secretion GO:0090274 IEA,cholecystokinin receptor activity GO:0004951 IEA,Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Insulin secretion - Homo sapiens (human) hsa04911 Pancreatic secretion - Homo sapiens (human) hsa04972,CHEMBL CHEMBL1773877,P32238,Cholecystokinin A receptor,1.0,PRIMARY,NO,Cc1ccc(c(F)c1)c2nc(ncc2c3ccc4OCCOc4c3)C(=O)N5CCN(CC5)c6cc(C(=O)O)c7ccccc7c6,3,7,"InChI=1S/C35H29FN4O5/c1-21-6-8-26(29(36)16-21)32-28(23-7-9-30-31(18-23)45-15-14-44-30)20-37-33(38-32)34(41)40-12-10-39(11-13-40)24-17-22-4-2-3-5-25(22)27(19-24)35(42)43/h2-9,16-20H,10-15H2,1H3,(H,42,43)",MAZYNSFCRNJVOU-UHFFFAOYSA-N,"c(""Cholecystokinin A receptor"", ""Cannabinoid CB2 receptor"", ""Cholecystokinin B receptor"", ""Voltage-gated potassium channel beta subunit Mink"")",886,CCKAR,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,lysosome GO:0005764 IEA endosome GO:0005768 IEA endoplasmic reticulum GO:0005783 IEA cytosol GO:0005829 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 8343165 TAS terminal bouton GO:0043195 IEA,temperature homeostasis GO:0001659 IEA gastric acid secretion GO:0001696 IEA neuron migration GO:0001764 IEA reduction of food intake in response to dietary excess GO:0002023 IEA phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 TAS 8343165 positive regulation of cytosolic calcium ion concentration GO:0007204 IEA axonogenesis GO:0007409 IEA response to nutrient GO:0007584 IEA digestion GO:0007586 TAS 8503909 feeding behavior GO:0007631 TAS 8503909 response to radiation GO:0009314 IEA response to heat GO:0009408 IEA insulin secretion GO:0030073 IEA pancreatic juice secretion GO:0030157 IEA forebrain development GO:0030900 IEA pancreas development GO:0031016 IEA organ regeneration GO:0031100 IEA actin cytoskeleton reorganization GO:0031532 IEA response to lipopolysaccharide GO:0032496 IEA cellular response to hormone stimulus GO:0032870 IEA cholecystokinin signaling pathway GO:0038188 IEA response to starvation GO:0042594 IEA regulation of potassium ion transport GO:0043266 IEA regulation of hormone secretion GO:0046883 IBA response to glucocorticoid GO:0051384 IEA regulation of calcium ion transport GO:0051924 IEA positive regulation of somatostatin secretion GO:0090274 IEA,cholecystokinin receptor activity GO:0004951 IEA,Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Insulin secretion - Homo sapiens (human) hsa04911 Pancreatic secretion - Homo sapiens (human) hsa04972,CHEMBL CHEMBL1269257,P32239,Cholecystokinin B receptor,1.0,PRIMARY,NO,CC(C)N(C(=O)CN1C(=O)[C@H](NC(=O)Nc2cccc(c2)C(=O)O)C(=O)N(c3ccccc3)c4ccccc14)c5ccccc5,2,11,"InChI=1S/C34H31N5O6/c1-22(2)38(25-14-5-3-6-15-25)29(40)21-37-27-18-9-10-19-28(27)39(26-16-7-4-8-17-26)32(42)30(31(37)41)36-34(45)35-24-13-11-12-23(20-24)33(43)44/h3-20,22,30H,21H2,1-2H3,(H,43,44)(H2,35,36,45)/t30-/m0/s1",CABBMMXFOOZVMS-PMERELPUSA-N,"c(""Cholecystokinin A receptor"", ""Cholecystokinin B receptor"")",887,GASR,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,plasma membrane GO:0005886 TAS integral component of plasma membrane 10913157 GO:0005887 IC,IEA GO:0001696 gastric acid secretion NAS 10913157 cell surface receptor signaling pathway GO:0007166 TAS 8455720 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 IDA 10913157 positive regulation of cytosolic calcium ion concentration GO:0007204 TAS 7681836 digestion GO:0007586 TAS 7681836 sensory perception GO:0007600 TAS 7681836 feeding behavior GO:0007631 TAS 10400698 cell proliferation GO:0008283 IDA 10913157 positive regulation of cell proliferation GO:0008284 IEA GO:0038188 cholecystokinin signaling pathway IEA GO:0043551 regulation of phosphatidylinositol 3-kinase activity IEA GO:0048565 digestive tract development IEA GO:0048732 gland development,TAS 7681836 phosphatidylinositol phospholipase C activity GO:0004435 TAS 7681836 cholecystokinin receptor activity GO:0004951 IPI 16963136 23597562 25416956 protein binding GO:0005515 IDA 10913157 gastrin receptor activity GO:0015054 IDA 1280419 8185642 type B gastrin/cholecystokinin receptor binding GO:0031741 TAS 10400698 1-phosphatidylinositol-3-kinase regulator activity GO:0046935,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04971 Gastric acid secretion - Homo sapiens (human),CHEMBL CHEMBL1807053,P34998,Corticotropin releasing factor receptor 1,1.0,PRIMARY,NO,CCC(CC)Nc1nc(C)c(nc1OC)c2ccc(OC(F)(F)F)cc2OC,45,72,"InChI=1S/C19H24F3N3O3/c1-6-12(7-2)24-17-18(27-5)25-16(11(3)23-17)14-9-8-13(10-15(14)26-4)28-19(20,21)22/h8-10,12H,6-7H2,1-5H3,(H,23,24)",PSUFQBRCUSJTDO-UHFFFAOYSA-N,"c(""Unchecked"", ""Betaine transporter"", ""Endothelin receptor ET-B"", ""Endothelin receptor ET-A"", ""Dopamine transporter"", ""Dopamine D3 receptor"", ""Dopamine D2 receptor"", ""Dopamine D1 receptor"", ""Cholecystokinin B receptor"", ""Cholecystokinin A receptor"", ""Cannabinoid CB2 receptor"", ""Cannabinoid CB1 receptor"", ""Calcitonin gene-related peptide type 1 receptor"", ""Bradykinin B2 receptor"", ""Bradykinin B1 receptor"", ""Angiotensin II type 2 (AT-2) receptor"", ""Type-1 angiotensin II receptor"", ""Norepinephrine transporter"", ""Beta-2 adrenergic receptor"", ""Beta-1 adrenergic receptor"", ""Alpha-2a adrenergic receptor"", ""Alpha-1a adrenergic receptor"", ""Adenosine A3 receptor"", ""Adenosine A1 receptor"", ""Corticotropin releasing factor receptor 1"", ""Epidermal growth factor receptor erbB1"", ""Interleukin-6"", ""Histamine H1 receptor"", ""Histamine H2 receptor"", ""Histamine H3 receptor"", ""Nischarin"", ""Insulin receptor"", ""Neurokinin 1 receptor"", ""Neurokinin 2 receptor"", ""Oxytocin receptor"", ""Platelet activating factor receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 5a (5-HT5a) receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Serotonin 7 (5-HT7) receptor"", ""Somatostatin"", ""Glucocorticoid receptor"", ""Thyrotropin-releasing hormone receptor"", ""Vasoactive intestinal polypeptide receptor 1"", ""Vasopressin V1a receptor"", ""Pro-epidermal growth factor"")",104909134,CRFR1,,,,,,CHEMBL CHEMBL2349310,P49238,C-X3-C chemokine receptor 1,1.0,PRIMARY,NO,CC(C)C[C@H](CO)Nc1nc(S[C@@H](C)c2ccccc2)nc3nc(N)sc13,3,12,"InChI=1S/C19H25N5OS2/c1-11(2)9-14(10-25)21-16-15-17(22-18(20)27-15)24-19(23-16)26-12(3)13-7-5-4-6-8-13/h4-8,11-12,14,25H,9-10H2,1-3H3,(H3,20,21,22,23,24)/t12-,14+/m0/s1",ZMQSLMZOWVGBSM-GXTWGEPZSA-N,"c(""Unchecked"", ""Adenosine A1 receptor"", ""Interleukin-8 receptor B"", ""C-X3-C chemokine receptor 1"")",1524,CX3C1,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-380108 Chemokine receptors bind chemokines R-HSA-500792 GPCR ligand binding,plasma membrane TAS GO:0005886 integral component of plasma membrane TAS 9390561 GO:0005887 neuronal cell body membrane IEA GO:0032809 neuron projection IEA GO:0043005 perinuclear region of cytoplasm IEA GO:0048471,positive regulation of neuroblast proliferation GO:0002052 IEA microglial cell activation involved in immune response GO:0002282 IEA negative regulation of chronic inflammatory response to non-antigenic stimulus GO:0002881 IEA chemotaxis GO:0006935 10754298 TAS cellular defense response GO:0006968 10754298 TAS cell adhesion GO:0007155 IEA G-protein coupled receptor signaling pathway GO:0007186 IEA memory GO:0007613 IEA response to wounding GO:0009611 10754298 TAS viral process GO:0016032 IEA negative regulation of angiogenesis GO:0016525 IEA cerebral cortex cell migration GO:0021795 IEA negative regulation of cell migration GO:0030336 IEA positive regulation of angiogenesis GO:0045766 IEA macrophage chemotaxis GO:0048246 IEA chemokine-mediated signaling pathway GO:0070098 IEA cellular response to lipopolysaccharide GO:0071222 IEA cellular response to transforming growth factor beta stimulus GO:0071560 IEA negative regulation of long-term synaptic potentiation GO:1900272 IEA negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 IEA,chemokine receptor activity GO:0004950 10754298 TAS protein binding GO:0005515 9931005 IPI C-X3-C chemokine receptor activity GO:0016495 IEA C-X3-C chemokine binding GO:0019960 23125415 IDA,hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human),CHEMBL CHEMBL3091687,P61073,C-X-C chemokine receptor type 4,1.0,PRIMARY,NO,NCCCCN(C[C@H]1Cc2ccccc2CN1)[C@H]3CCCc4cccnc34,15,21,"InChI=1S/C23H32N4/c24-12-3-4-14-27(22-11-5-9-18-10-6-13-25-23(18)22)17-21-15-19-7-1-2-8-20(19)16-26-21/h1-2,6-8,10,13,21-22,26H,3-5,9,11-12,14-17,24H2/t21-,22+/m1/s1",MYCKNKHATQGHEV-YADHBBJMSA-N,"c(""C-X-C chemokine receptor type 4"", ""C-X-C chemokine receptor type 6"", ""C-X-C chemokine receptor type 5"", ""C-X-C chemokine receptor type 3"", ""Interleukin-8 receptor B"", ""Interleukin-8 receptor A"", ""C-C chemokine receptor type 9"", ""C-C chemokine receptor type 8"", ""C-C chemokine receptor type 7"", ""C-C chemokine receptor type 6"", ""C-C chemokine receptor type 5"", ""C-C chemokine receptor type 4"", ""C-C chemokine receptor type 3"", ""C-C chemokine receptor type 2"", ""C-C chemokine receptor type 1"")",7852,CXCR4,Signal Transduction R-HSA-162582 HIV Life Cycle R-HSA-162587 Early Phase of HIV Life Cycle R-HSA-162594 HIV Infection R-HSA-162906 Disease R-HSA-1643685 Binding and entry of HIV virion R-HSA-173107 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 Chemokine receptors bind chemokines R-HSA-380108 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792 Infectious disease R-HSA-5663205,"GO:0005737 cytoplasm 10415069 TAS GO:0005764 lysosome 21540189 IDA GO:0005769 early endosome 21540189 IDA GO:0005770 late endosome 21540189 IDA GO:0005886 plasma membrane 21540189 IDA GO:0005886 plasma membrane TAS GO:0009986 cell surface 10521508 10644702 18308860 19106094 23620790 IDA GO:0016021 integral component of membrane IEA GO:0016023 cytoplasmic, membrane-bounded vesicle 19106094 IDA GO:0030054 cell junction IEA GO:0031252 cell leading edge 12421915 IDA GO:0031410 cytoplasmic vesicle 10521508 IDA GO:0070062 extracellular exosome 20458337 IDA",activation of MAPK activity 10570282 GO:0000187 TAS response to hypoxia 15174142 GO:0001666 IEP neuron migration GO:0001764 IEA epithelial cell development GO:0002064 IEA dendritic cell chemotaxis 16621978 GO:0002407 TAS apoptotic process 10942389 GO:0006915 TAS inflammatory response 8276799 GO:0006954 TAS G-protein coupled receptor signaling pathway 10644702 GO:0007186 IDA positive regulation of cytosolic calcium ion concentration 10228019 GO:0007204 TAS neuron recognition GO:0008038 IEA response to virus 10583963 GO:0009615 TAS fusion of virus membrane with host plasma membrane GO:0019064 TAS calcium-mediated signaling 19064997 GO:0019722 IMP telencephalon cell migration GO:0022029 IEA entry into host cell GO:0030260 TAS regulation of cell migration GO:0030334 IEA regulation of programmed cell death GO:0043067 IEA myelin maintenance GO:0043217 ISS positive regulation of oligodendrocyte differentiation GO:0048714 ISS regulation of chemotaxis 19106094 GO:0050920 IMP regulation of calcium ion transport GO:0051924 IEA cardiac muscle contraction GO:0060048 IEA chemokine-mediated signaling pathway GO:0070098 IEA cellular response to cytokine stimulus 21540189 GO:0071345 IDA,virus receptor activity GO:0001618 IEA actin binding 12421915 GO:0003779 IDA G-protein coupled receptor activity 8276799 GO:0004930 TAS protein binding 10644702 12421915 17077324 19106094 19665027 20215400 23773523 23926103 24094005 GO:0005515 IPI drug binding GO:0008144 IEA coreceptor activity 10754293 GO:0015026 TAS C-X-C chemokine receptor activity 9468539 GO:0016494 NAS cytokine binding GO:0019955 IEA ubiquitin protein ligase binding 19116316 GO:0031625 IPI myosin light chain binding 12421915 GO:0032027 IDA ubiquitin binding 20228059 GO:0043130 IDA,hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04144 Endocytosis - Homo sapiens (human) hsa04360 Axon guidance - Homo sapiens (human) hsa04670 Leukocyte transendothelial migration - Homo sapiens (human) hsa04672 Intestinal immune network for IgA production - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human),CHEMBL CHEMBL3581264,P25106,C-X-C chemokine receptor type 7,1.0,PRIMARY,NO,NC(=N)NCCC[C@@H]1NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H]3CCCN3C(=O)[C@H](Cc4ccc5ccccc5c4)NC1=O,2,7,"InChI=1S/C39H51N11O6/c40-38(41)44-17-3-8-28-33(52)46-29(9-4-18-45-39(42)43)34(53)49-31(22-24-11-14-25-6-1-2-7-26(25)20-24)37(56)50-19-5-10-32(50)36(55)48-30(35(54)47-28)21-23-12-15-27(51)16-13-23/h1-2,6-7,11-16,20,28-32,51H,3-5,8-10,17-19,21-22H2,(H,46,52)(H,47,54)(H,48,55)(H,49,53)(H4,40,41,44)(H4,42,43,45)/t28-,29-,30+,31-,32-/m0/s1",AVNDVFCGYOONJV-LUKCZKMGSA-N,"c(""C-X-C chemokine receptor type 7"", ""C-X-C chemokine receptor type 4"")",57007,ACKR3,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-380108 Chemokine receptors bind chemokines R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,endosome GO:0005768 IDA 22300987 early endosome GO:0005769 IEA plasma membrane GO:0005886 IDA 22300987 plasma membrane GO:0005886 TAS clathrin-coated pit GO:0005905 IDA 22457824 cell surface GO:0009986 IDA 22457824 integral component of membrane GO:0016021 IEA intracellular membrane-bounded organelle GO:0043231 IDA perinuclear region of cytoplasm GO:0048471 IEA recycling endosome GO:0055037 IEA,GO:0001525 angiogenesis IEA GO:0001570 vasculogenesis IEA 22020285 GO:0002230 positive regulation of defense response to virus by host IMP GO:0006935 chemotaxis IEA GO:0007155 cell adhesion IEA GO:0007186 G-protein coupled receptor signaling pathway IEA GO:0016032 viral process IEA 22300987 22457824 GO:0031623 receptor internalization IMP 20388803 GO:0070098 chemokine-mediated signaling pathway IMP 22300987 GO:0070374 positive regulation of ERK1 and ERK2 cascade IMP 22020285 GO:0098792 xenophagy IMP 20388803 GO:1902230 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage IMP,22300987 GO:0005044 scavenger receptor activity IMP 22300987 22457824 GO:0005515 protein binding IPI GO:0015026 coreceptor activity IEA 20388803 GO:0016494 C-X-C chemokine receptor activity IMP 22300987 GO:0019958 C-X-C chemokine binding IMP,Cytokine-cytokine receptor interaction - Homo sapiens (human) hsa04060,CHEMBL CHEMBL26915,P23219,Cyclooxygenase-1,1.0,PRIMARY,NO,COc1ccc(cc1)n2nc(cc2c3ccc(Cl)cc3)C(F)(F)F,5,43,"InChI=1S/C17H12ClF3N2O/c1-24-14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3",PQUGCKBLVKJMNT-UHFFFAOYSA-N,"c(""Carbonic anhydrase I"", ""Carbonic anhydrase II"", ""Carbonic anhydrase IX"", ""Cyclooxygenase-1"", ""Cyclooxygenase-2"", ""HUVEC"", ""PC-3"", ""Unchecked"", ""Thyroid stimulating hormone receptor"", ""Hypoxia-inducible factor 1 alpha"", ""Peripheral myelin protein 22"", ""Bloom syndrome protein"", ""Thrombopoietin"", ""Neuropeptide S receptor"", ""M-phase phosphoprotein 8"", ""Histone-lysine N-methyltransferase, H3 lysine-9 specific 3"", ""Runt-related transcription factor 1/Core-binding factor subunit beta"")",5742,PGH1,COX reactions R-HSA-140180 Metabolism R-HSA-1430728 Biological oxidations R-HSA-211859 Phase 1 - Functionalization of compounds R-HSA-211945 Arachidonic acid metabolism R-HSA-2142753 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 Metabolism of lipids and lipoproteins R-HSA-556833,IEA GO:0001750 photoreceptor outer segment ISS GO:0005634 nucleus IEA GO:0005635 nuclear envelope IDA 12355421 cytoplasm GO:0005737 ISS GO:0005737 cytoplasm TAS GO:0005789 endoplasmic reticulum membrane IDA GO:0005794 Golgi apparatus IDA GO:0043231 intracellular membrane-bounded organelle ISS GO:0043231 intracellular membrane-bounded organelle IDA 18570454 extracellular exosome GO:0070062,prostaglandin biosynthetic process ISS GO:0001516 lipid metabolic process NAS 1907252 GO:0006629 xenobiotic metabolic process TAS GO:0006805 inflammatory response IEA GO:0006954 response to oxidative stress IEA GO:0006979 aging IEA GO:0007568 learning IEA GO:0007612 memory IEA GO:0007613 regulation of blood pressure ISS GO:0008217 response to organonitrogen compound IEA GO:0010243 negative regulation of norepinephrine secretion IEA GO:0010700 sensory perception of pain IEA GO:0019233 cyclooxygenase pathway IDA 1380156 GO:0019371 cyclooxygenase pathway TAS GO:0019371 negative regulation of epinephrine secretion IEA GO:0032811 maintenance of blood-brain barrier IEA GO:0035633 regulation of cell proliferation IEA GO:0042127 positive regulation of vasoconstriction IEA GO:0045907 positive regulation of smooth muscle contraction IEA GO:0045987 response to corticosterone IEA GO:0051412 oxidation-reduction process IEA GO:0055114 response to fatty acid IEA GO:0070542 cellular oxidant detoxification IEA GO:0098869,peroxidase activity TAS GO:0004601 prostaglandin-endoperoxide synthase activity IDA 1380156 GO:0004666 prostaglandin-endoperoxide synthase activity TAS GO:0004666 lipid binding IEA GO:0008289 heme binding IEA GO:0020037 metal ion binding IEA GO:0046872 dioxygenase activity IEA GO:0051213,hsa00590 Arachidonic acid metabolism - Homo sapiens (human) hsa04611 Platelet activation - Homo sapiens (human) hsa04726 Serotonergic synapse - Homo sapiens (human) hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human),CHEMBL CHEMBL3342944,Q9NS75,Cysteinyl leukotriene receptor 2,1.0,PRIMARY,NO,OC(=O)C1CCCC(C1)NC(=O)c2cc(ccc2OCCCc3ccc(OCCCCOC4CCCCC4)cc3)C(=O)O,2,4,"InChI=1S/C34H45NO8/c36-32(35-27-10-6-9-25(22-27)33(37)38)30-23-26(34(39)40)15-18-31(30)43-21-7-8-24-13-16-29(17-14-24)42-20-5-4-19-41-28-11-2-1-3-12-28/h13-18,23,25,27-28H,1-12,19-22H2,(H,35,36)(H,37,38)(H,39,40)",HRJWSEPIRZRGCL-UHFFFAOYSA-N,"c(""Cysteinyl leukotriene receptor 2"", ""Cysteinyl leukotriene receptor 1"")",57105,CLTR2,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 Eicosanoid ligand-binding receptors R-HSA-391903 Leukotriene receptors R-HSA-391906 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,ND GO:0005575 cellular_component TAS GO:0005886 plasma membrane IBA GO:0005887 integral component of plasma membrane,GO:0006955 immune response 10913337 NAS GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA GO:0007218 neuropeptide signaling pathway IBA GO:0010942 positive regulation of cell death IEA GO:0045766 positive regulation of angiogenesis IEA GO:0061737 leukotriene signaling pathway IEA GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA,GO:0001631 cysteinyl leukotriene receptor activity IBA GO:0004974 leukotriene receptor activity 10913337 NAS GO:0005515 protein binding 21203429 IPI GO:0008528 G-protein coupled peptide receptor activity IBA,Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL1275682,Q9UIQ6,Cystinyl aminopeptidase,1.0,ORTHOGONAL,NO,CC[C@H](C)[C@H](NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc3ccccc3)C(=O)O,2,4,"InChI=1S/C31H45N7O6/c1-5-19(4)26(37-28(40)25(32)18(2)3)29(41)35-22(15-21-16-33-17-34-21)30(42)38-13-9-12-24(38)27(39)36-23(31(43)44)14-20-10-7-6-8-11-20/h6-8,10-11,16-19,22-26H,5,9,12-15,32H2,1-4H3,(H,33,34)(H,35,41)(H,36,39)(H,37,40)(H,43,44)/t19-,22-,23-,24-,25-,26-/m0/s1",FJPCLEAXXQFJFD-KTHKBMNISA-N,"c(""Cystinyl aminopeptidase"", ""Aminopeptidase N"")",4012,LCAP,R-HSA-1236975 Antigen processing-Cross presentation R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-1280218 Adaptive Immune System R-HSA-1445148 Translocation of GLUT4 to the plasma membrane R-HSA-168256 Immune System R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport R-HSA-983169 Class I MHC mediated antigen processing & presentation,extracellular region GO:0005576 IEA intracellular GO:0005622 15691326 IDA lysosomal membrane GO:0005765 17897319 IDA cytosol GO:0005829 TAS plasma membrane GO:0005886 9177475 TAS integral component of plasma membrane GO:0005887 9177475 TAS membrane GO:0016020 19946888 IDA cytoplasmic vesicle membrane GO:0030659 TAS early endosome lumen GO:0031905 TAS perinuclear region of cytoplasm GO:0048471 IEA,"protein polyubiquitination GO:0000209 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 TAS proteolysis GO:0006508 IEA signal transduction GO:0007165 IBA cell-cell signaling GO:0007267 TAS 8550619 female pregnancy GO:0007565 TAS 8550619 regulation of blood pressure GO:0008217 IBA protein catabolic process GO:0030163 IEA peptide catabolic process GO:0043171 IBA SMAD protein signal transduction GO:0060395 IEA membrane organization GO:0061024 TAS",aminopeptidase activity GO:0004177 EXP 9668046 11062501 19498108 19918052 aminopeptidase activity GO:0004177 TAS 15691326 protein binding GO:0005515 IPI 25416956 metallopeptidase activity GO:0008237 TAS 9177475 zinc ion binding GO:0008270 IEA peptide binding GO:0042277 IBA metalloaminopeptidase activity GO:0070006 IBA,Renin-angiotensin system - Homo sapiens (human) hsa04614,CHEMBL CHEMBL1277623,Q9UIQ6,Cystinyl aminopeptidase,1.0,PRIMARY,NO,N[C@H]1CCSSC[C@H](NC(=O)C[C@H](Cc2ccc(O)cc2)NC1=O)C(=O)NCc3ccccc3CC(=O)O,2,5,"InChI=1S/C26H32N4O6S2/c27-21-9-10-37-38-15-22(26(36)28-14-18-4-2-1-3-17(18)12-24(33)34)30-23(32)13-19(29-25(21)35)11-16-5-7-20(31)8-6-16/h1-8,19,21-22,31H,9-15,27H2,(H,28,36)(H,29,35)(H,30,32)(H,33,34)/t19-,21-,22-/m0/s1",VZYRMNZEFCZSER-BVSLBCMMSA-N,"c(""Cystinyl aminopeptidase"", ""Aminopeptidase N"")",4012,LCAP,R-HSA-1236975 Antigen processing-Cross presentation R-HSA-1236977 Endosomal/Vacuolar pathway R-HSA-1280218 Adaptive Immune System R-HSA-1445148 Translocation of GLUT4 to the plasma membrane R-HSA-168256 Immune System R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport R-HSA-983169 Class I MHC mediated antigen processing & presentation,extracellular region GO:0005576 IEA intracellular GO:0005622 15691326 IDA lysosomal membrane GO:0005765 17897319 IDA cytosol GO:0005829 TAS plasma membrane GO:0005886 9177475 TAS integral component of plasma membrane GO:0005887 9177475 TAS membrane GO:0016020 19946888 IDA cytoplasmic vesicle membrane GO:0030659 TAS early endosome lumen GO:0031905 TAS perinuclear region of cytoplasm GO:0048471 IEA,"protein polyubiquitination GO:0000209 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent GO:0002480 TAS proteolysis GO:0006508 IEA signal transduction GO:0007165 IBA cell-cell signaling GO:0007267 TAS 8550619 female pregnancy GO:0007565 TAS 8550619 regulation of blood pressure GO:0008217 IBA protein catabolic process GO:0030163 IEA peptide catabolic process GO:0043171 IBA SMAD protein signal transduction GO:0060395 IEA membrane organization GO:0061024 TAS",aminopeptidase activity GO:0004177 EXP 9668046 11062501 19498108 19918052 aminopeptidase activity GO:0004177 TAS 15691326 protein binding GO:0005515 IPI 25416956 metallopeptidase activity GO:0008237 TAS 9177475 zinc ion binding GO:0008270 IEA peptide binding GO:0042277 IBA metalloaminopeptidase activity GO:0070006 IBA,Renin-angiotensin system - Homo sapiens (human) hsa04614,CHEMBL CHEMBL3613921,P14920,D-amino-acid oxidase,1.0,PRIMARY,NO,OC1=NN(Cc2cccc3ccccc23)C(=O)NC1=O,4,9,"InChI=1S/C14H11N3O3/c18-12-13(19)16-17(14(20)15-12)8-10-6-3-5-9-4-1-2-7-11(9)10/h1-7H,8H2,(H,16,19)(H,15,18,20)",DNIURSGRFSKVEF-UHFFFAOYSA-N,"c(""D-amino-acid oxidase"", ""Glutamate NMDA receptor; GRIN1/GRIN2A"", ""Glycine receptor subunit alpha-1"", ""Monoamine oxidase A"", ""Monoamine oxidase B"")",1610,OXDA,Metabolism R-HSA-1430728 Glyoxylate metabolism R-HSA-389661 Metabolism of amino acids and derivatives R-HSA-71291,mitochondrial outer membrane colocalizes_with 21679769 GO:0005741 IDA peroxisome 18544534 GO:0005777 IDA peroxisomal membrane 21679769 GO:0005778 IDA peroxisomal matrix GO:0005782 TAS cytosol 21679769 GO:0005829 IDA,IDA 16616139 proline catabolic process GO:0006562 IDA 18544534 D-serine catabolic process GO:0036088 IDA 17303072 dopamine biosynthetic process GO:0042416 TAS GO:0046487 glyoxylate metabolic process IEA GO:0055114 oxidation-reduction process IDA 16616139 20603179 D-alanine catabolic process GO:0055130 IDA 21679769 D-serine metabolic process GO:0070178,IDA 12364586 16616139 17303072 18544534 19309736 20603179 D-amino-acid oxidase activity GO:0003884 TAS GO:0003884 D-amino-acid oxidase activity IPI 20178365 receptor binding GO:0005102 IPI 12364586 20521334 21679769 21988832 25416956 protein binding GO:0005515 IDA 16616139 19309736 protein dimerization activity GO:0046983 IDA 20603179 cofactor binding GO:0048037 IDA 16616139 19309736 20521334 FAD binding GO:0071949,"hsa00260 Glycine, serine and threonine metabolism - Homo sapiens (human) hsa00330 Arginine and proline metabolism - Homo sapiens (human) hsa00472 D-Arginine and D-ornithine metabolism - Homo sapiens (human) hsa04146 Peroxisome - Homo sapiens (human)",CHEMBL CHEMBL246003,P41143,Delta opioid receptor,1.0,ORTHOGONAL,NO,COc1c(O)ccc2C[C@H]3N(C)CC[C@@]4(Cc5[nH]c6ccccc6c5C[C@@]34O)c12,3,8,"InChI=1S/C24H26N2O3/c1-26-10-9-23-13-18-16(15-5-3-4-6-17(15)25-18)12-24(23,28)20(26)11-14-7-8-19(27)22(29-2)21(14)23/h3-8,20,25,27-28H,9-13H2,1-2H3/t20-,23-,24-/m1/s1",NGVIJPSZRGAUGY-AGILITTLSA-N,"c(""Kappa opioid receptor"", ""Unchecked"", ""Delta opioid receptor"", ""Mu opioid receptor"")",4985,OPRD,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,GO:0005737 cytoplasm IEA GO:0005886 plasma membrane TAS 7808419 GO:0005887 integral component of plasma membrane TAS 22184124 GO:0031226 intrinsic component of plasma membrane IDA GO:0031982 vesicle IEA GO:0032590 dendrite membrane IEA GO:0043005 neuron projection IBA GO:0043679 axon terminus IEA GO:0045121 membrane raft IEA GO:0045211 postsynaptic membrane IEA,"16325578 IDA GO:0000060 protein import into nucleus, translocation 9548483 TAS GO:0006955 immune response 16325578 IDA GO:0007186 G-protein coupled receptor signaling pathway 7808419 TAS GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISS GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA GO:0007218 neuropeptide signaling pathway IBA GO:0007268 chemical synaptic transmission IEA GO:0008344 adult locomotory behavior 24613828 IDA GO:0010629 negative regulation of gene expression IBA GO:0019233 sensory perception of pain 24613828 IDA GO:0032460 negative regulation of protein oligomerization 24613828 IC GO:0032793 positive regulation of CREB transcription factor activity 24613828 IDA GO:0033138 positive regulation of peptidyl-serine phosphorylation 9548483 IMP GO:0038003 opioid receptor signaling pathway IEA GO:0042755 eating behavior 24613828 IDA GO:0051881 regulation of mitochondrial membrane potential IEA GO:0051924 regulation of calcium ion transport IEA GO:0051930 regulation of sensory perception of pain IEA GO:0071363 cellular response to growth factor stimulus 24613828 IDA GO:0071456 cellular response to hypoxia 24613828 IDA GO:0097237 cellular response to toxic substance",22184124 IDA GO:0004985 opioid receptor activity 15086532 20528919 IPI GO:0005515 protein binding 9548483 IMP GO:0038046 enkephalin receptor activity IBA GO:0042923 neuropeptide binding,cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL561339,P41143,Delta opioid receptor,1.0,PRIMARY,NO,CCN(CC)C(=O)c1ccc(C2=CC3(CCNCC3)Oc4ccccc24)c(O)c1,4,8,"InChI=1S/C24H28N2O3/c1-3-26(4-2)23(28)17-9-10-18(21(27)15-17)20-16-24(11-13-25-14-12-24)29-22-8-6-5-7-19(20)22/h5-10,15-16,25,27H,3-4,11-14H2,1-2H3",ALGHKWSXJUQNJJ-UHFFFAOYSA-N,"c(""Delta opioid receptor"", ""Mu opioid receptor"", ""Kappa opioid receptor"", ""Unchecked"", ""Voltage-gated potassium channel subunit Kv4.3"")",4985,OPRD,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,GO:0005737 cytoplasm IEA GO:0005886 plasma membrane TAS 7808419 GO:0005887 integral component of plasma membrane TAS 22184124 GO:0031226 intrinsic component of plasma membrane IDA GO:0031982 vesicle IEA GO:0032590 dendrite membrane IEA GO:0043005 neuron projection IBA GO:0043679 axon terminus IEA GO:0045121 membrane raft IEA GO:0045211 postsynaptic membrane IEA,"16325578 IDA GO:0000060 protein import into nucleus, translocation 9548483 TAS GO:0006955 immune response 16325578 IDA GO:0007186 G-protein coupled receptor signaling pathway 7808419 TAS GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISS GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA GO:0007218 neuropeptide signaling pathway IBA GO:0007268 chemical synaptic transmission IEA GO:0008344 adult locomotory behavior 24613828 IDA GO:0010629 negative regulation of gene expression IBA GO:0019233 sensory perception of pain 24613828 IDA GO:0032460 negative regulation of protein oligomerization 24613828 IC GO:0032793 positive regulation of CREB transcription factor activity 24613828 IDA GO:0033138 positive regulation of peptidyl-serine phosphorylation 9548483 IMP GO:0038003 opioid receptor signaling pathway IEA GO:0042755 eating behavior 24613828 IDA GO:0051881 regulation of mitochondrial membrane potential IEA GO:0051924 regulation of calcium ion transport IEA GO:0051930 regulation of sensory perception of pain IEA GO:0071363 cellular response to growth factor stimulus 24613828 IDA GO:0071456 cellular response to hypoxia 24613828 IDA GO:0097237 cellular response to toxic substance",22184124 IDA GO:0004985 opioid receptor activity 15086532 20528919 IPI GO:0005515 protein binding 9548483 IMP GO:0038046 enkephalin receptor activity IBA GO:0042923 neuropeptide binding,cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL3596369,P41143,Delta opioid receptor,1.0,ORTHOGONAL,YES,Cl.CCCN1CC[C@]23[C@H]4Oc5c(O)ccc(C[C@@H]1[C@]2(O)Cc6cc7ccccc7nc46)c35,3,7,"InChI=1S/C26H26N2O3.ClH/c1-2-10-28-11-9-25-21-16-7-8-19(29)23(21)31-24(25)22-17(14-26(25,30)20(28)13-16)12-15-5-3-4-6-18(15)27-22;/h3-8,12,20,24,29-30H,2,9-11,13-14H2,1H3;1H/t20?,24-,25-,26+;/m0./s1",ZSMAGMCBOOIRNX-XXCZMEBESA-N,"c(""Delta opioid receptor"", ""Mu opioid receptor"", ""Kappa opioid receptor"", ""Unchecked"")",4985,OPRD,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,GO:0005737 cytoplasm IEA GO:0005886 plasma membrane TAS 7808419 GO:0005887 integral component of plasma membrane TAS 22184124 GO:0031226 intrinsic component of plasma membrane IDA GO:0031982 vesicle IEA GO:0032590 dendrite membrane IEA GO:0043005 neuron projection IBA GO:0043679 axon terminus IEA GO:0045121 membrane raft IEA GO:0045211 postsynaptic membrane IEA,"16325578 IDA GO:0000060 protein import into nucleus, translocation 9548483 TAS GO:0006955 immune response 16325578 IDA GO:0007186 G-protein coupled receptor signaling pathway 7808419 TAS GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISS GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA GO:0007218 neuropeptide signaling pathway IBA GO:0007268 chemical synaptic transmission IEA GO:0008344 adult locomotory behavior 24613828 IDA GO:0010629 negative regulation of gene expression IBA GO:0019233 sensory perception of pain 24613828 IDA GO:0032460 negative regulation of protein oligomerization 24613828 IC GO:0032793 positive regulation of CREB transcription factor activity 24613828 IDA GO:0033138 positive regulation of peptidyl-serine phosphorylation 9548483 IMP GO:0038003 opioid receptor signaling pathway IEA GO:0042755 eating behavior 24613828 IDA GO:0051881 regulation of mitochondrial membrane potential IEA GO:0051924 regulation of calcium ion transport IEA GO:0051930 regulation of sensory perception of pain IEA GO:0071363 cellular response to growth factor stimulus 24613828 IDA GO:0071456 cellular response to hypoxia 24613828 IDA GO:0097237 cellular response to toxic substance",22184124 IDA GO:0004985 opioid receptor activity 15086532 20528919 IPI GO:0005515 protein binding 9548483 IMP GO:0038046 enkephalin receptor activity IBA GO:0042923 neuropeptide binding,cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL294616,P41143,Delta opioid receptor,1.0,PRIMARY,YES,CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@H](Cc3ccccc3)C(=O)N[C@H]1C(=O)O,4,111,"InChI=1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21+,23-,24-/m0/s1",MCMMCRYPQBNCPH-DVKRWUGUSA-N,"c(""Unchecked"", ""Opioid receptors; mu & delta"", ""Delta opioid receptor"", ""Opioid receptors; mu/kappa/delta"", ""Kappa opioid receptor"", ""Mu opioid receptor"", ""Opioid receptors; delta & kappa"", ""P-glycoprotein 1"", ""Nociceptin receptor"", ""Solute carrier organic anion transporter family member 1A2"")",4985,OPRD,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,GO:0005737 cytoplasm IEA GO:0005886 plasma membrane TAS 7808419 GO:0005887 integral component of plasma membrane TAS 22184124 GO:0031226 intrinsic component of plasma membrane IDA GO:0031982 vesicle IEA GO:0032590 dendrite membrane IEA GO:0043005 neuron projection IBA GO:0043679 axon terminus IEA GO:0045121 membrane raft IEA GO:0045211 postsynaptic membrane IEA,"16325578 IDA GO:0000060 protein import into nucleus, translocation 9548483 TAS GO:0006955 immune response 16325578 IDA GO:0007186 G-protein coupled receptor signaling pathway 7808419 TAS GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISS GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA GO:0007218 neuropeptide signaling pathway IBA GO:0007268 chemical synaptic transmission IEA GO:0008344 adult locomotory behavior 24613828 IDA GO:0010629 negative regulation of gene expression IBA GO:0019233 sensory perception of pain 24613828 IDA GO:0032460 negative regulation of protein oligomerization 24613828 IC GO:0032793 positive regulation of CREB transcription factor activity 24613828 IDA GO:0033138 positive regulation of peptidyl-serine phosphorylation 9548483 IMP GO:0038003 opioid receptor signaling pathway IEA GO:0042755 eating behavior 24613828 IDA GO:0051881 regulation of mitochondrial membrane potential IEA GO:0051924 regulation of calcium ion transport IEA GO:0051930 regulation of sensory perception of pain IEA GO:0071363 cellular response to growth factor stimulus 24613828 IDA GO:0071456 cellular response to hypoxia 24613828 IDA GO:0097237 cellular response to toxic substance",22184124 IDA GO:0004985 opioid receptor activity 15086532 20528919 IPI GO:0005515 protein binding 9548483 IMP GO:0038046 enkephalin receptor activity IBA GO:0042923 neuropeptide binding,cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL3235321,O75907,Diacylglycerol O-acyltransferase 1,1.0,ORTHOGONAL,NO,CC1(C)Oc2nc(nc(N)c2N=C1c3ccc4c(CC[C@@]45CC[C@H](CC(=O)O)CC5)c3)C(F)(F)F,4,7,"InChI=1S/C25H27F3N4O3/c1-23(2)19(30-18-20(29)31-22(25(26,27)28)32-21(18)35-23)15-3-4-16-14(12-15)7-10-24(16)8-5-13(6-9-24)11-17(33)34/h3-4,12-13H,5-11H2,1-2H3,(H,33,34)(H2,29,31,32)/t13-,24-",YFJNLPDVCDNOMJ-OJPDTXNBSA-N,"c(""Diacylglycerol O-acyltransferase 1"", ""Acyl coenzyme A:cholesterol acyltransferase 1"", ""Diacylglycerol O-acyltransferase 2"", ""Unchecked"", ""Acyl coenzyme A:cholesterol acyltransferase 2"")",8694,DGAT1,"R-HSA-1430728 Metabolism R-HSA-1482883 Acyl chain remodeling of DAG and TAG R-HSA-1483206 Glycerophospholipid biosynthesis R-HSA-1483257 Phospholipid metabolism R-HSA-535734 Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-75109 Triglyceride Biosynthesis",endoplasmic reticulum membrane IBA GO:0005789 endoplasmic reticulum membrane TAS GO:0005789 integral component of membrane ISS GO:0016021,triglyceride metabolic process GO:0006641 9756920 TAS triglyceride biosynthetic process GO:0019432 18238778 18458083 IDA triglyceride biosynthetic process GO:0019432 TAS lipid storage GO:0019915 ISS very-low-density lipoprotein particle assembly GO:0034379 15308631 IMP long-chain fatty-acyl-CoA metabolic process GO:0035336 ISS acylglycerol acyl-chain remodeling GO:0036155 TAS retinol metabolic process GO:0042572 IEA diacylglycerol metabolic process GO:0046339 ISS fatty acid homeostasis GO:0055089 IEA,"2-acylglycerol O-acyltransferase activity GO:0003846 IEA diacylglycerol O-acyltransferase activity GO:0004144 11672446 EXP diacylglycerol O-acyltransferase activity GO:0004144 18458083 IDA diacylglycerol O-acyltransferase activity GO:0004144 TAS protein binding GO:0005515 23420847 IPI transferase activity, transferring acyl groups GO:0016746 9756920 TAS retinol O-fatty-acyltransferase activity GO:0050252 IEA",hsa00561 Glycerolipid metabolism - Homo sapiens (human) hsa00830 Retinol metabolism - Homo sapiens (human) hsa04975 Fat digestion and absorption - Homo sapiens (human),CHEMBL CHEMBL2178953,O75907,Diacylglycerol O-acyltransferase 1,1.0,PRIMARY,NO,Cc1nc(C)c(nc1C(=O)N)c2ccc(cc2)[C@@H]3CC[C@@H](CC(=O)O)CC3,6,14,"InChI=1S/C21H25N3O3/c1-12-19(24-20(21(22)27)13(2)23-12)17-9-7-16(8-10-17)15-5-3-14(4-6-15)11-18(25)26/h7-10,14-15H,3-6,11H2,1-2H3,(H2,22,27)(H,25,26)/t14-,15-",YXFNPRHZMOGREC-SHTZXODSSA-N,"c(""Phosphodiesterase 10A"", ""Muscarinic acetylcholine receptor M2"", ""Anandamide amidohydrolase"", ""Acyl coenzyme A:cholesterol acyltransferase 1"", ""Acyl coenzyme A:cholesterol acyltransferase 2"", ""Diacylglycerol O-acyltransferase 1"", ""Homo sapiens"")",8694,DGAT1,"R-HSA-1430728 Metabolism R-HSA-1482883 Acyl chain remodeling of DAG and TAG R-HSA-1483206 Glycerophospholipid biosynthesis R-HSA-1483257 Phospholipid metabolism R-HSA-535734 Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-75109 Triglyceride Biosynthesis",endoplasmic reticulum membrane IBA GO:0005789 endoplasmic reticulum membrane TAS GO:0005789 integral component of membrane ISS GO:0016021,triglyceride metabolic process GO:0006641 9756920 TAS triglyceride biosynthetic process GO:0019432 18238778 18458083 IDA triglyceride biosynthetic process GO:0019432 TAS lipid storage GO:0019915 ISS very-low-density lipoprotein particle assembly GO:0034379 15308631 IMP long-chain fatty-acyl-CoA metabolic process GO:0035336 ISS acylglycerol acyl-chain remodeling GO:0036155 TAS retinol metabolic process GO:0042572 IEA diacylglycerol metabolic process GO:0046339 ISS fatty acid homeostasis GO:0055089 IEA,"2-acylglycerol O-acyltransferase activity GO:0003846 IEA diacylglycerol O-acyltransferase activity GO:0004144 11672446 EXP diacylglycerol O-acyltransferase activity GO:0004144 18458083 IDA diacylglycerol O-acyltransferase activity GO:0004144 TAS protein binding GO:0005515 23420847 IPI transferase activity, transferring acyl groups GO:0016746 9756920 TAS retinol O-fatty-acyltransferase activity GO:0050252 IEA",hsa00561 Glycerolipid metabolism - Homo sapiens (human) hsa00830 Retinol metabolism - Homo sapiens (human) hsa04975 Fat digestion and absorption - Homo sapiens (human),CHEMBL CHEMBL3261920,P53634,Dipeptidyl peptidase I,1.0,ORTHOGONAL,NO,CSc1cc(ccc1C#N)c2ccc(C[C@H](NC(=O)[C@@H]3CCCCN3)C#N)cc2,5,6,"InChI=1S/C23H24N4OS/c1-29-22-13-18(9-10-19(22)14-24)17-7-5-16(6-8-17)12-20(15-25)27-23(28)21-4-2-3-11-26-21/h5-10,13,20-21,26H,2-4,11-12H2,1H3,(H,27,28)/t20-,21-/m0/s1",NMLYRXXREIIYKN-SFTDATJTSA-N,"c(""Dipeptidyl peptidase I"", ""Cathepsin K"", ""Cathepsin L"", ""Cathepsin S"", ""Cathepsin B"")",1075,CATC,Adaptive Immune System R-HSA-1280218 Immune System R-HSA-168256 MHC class II antigen presentation R-HSA-2132295,GO:0000139 Golgi membrane IEA GO:0005615 extracellular space 16502470 IDA GO:0005764 lysosome 18307834 ISS GO:0005764 lysosome 7665576 TAS GO:0005788 endoplasmic reticulum lumen TAS GO:0016020 membrane 19946888 IDA GO:0030134 ER to Golgi transport vesicle TAS GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane TAS GO:0070062 extracellular exosome 19056867 19199708 23376485 23533145 IDA,T cell mediated cytotoxicity GO:0001913 IEA proteolysis 8811434 GO:0006508 IDA ER to Golgi vesicle-mediated transport GO:0006888 TAS apoptotic process GO:0006915 IEA immune response 9092576 GO:0006955 TAS aging GO:0007568 IEA response to organic substance GO:0010033 IEA COPII vesicle coating GO:0048208 TAS proteolysis involved in cellular protein catabolic process GO:0051603 IBA positive regulation of proteolysis involved in cellular protein catabolic process 18307834 GO:1903052 ISS positive regulation of apoptotic signaling pathway GO:2001235 IEA,cysteine-type endopeptidase activity GO:0004197 IBA serine-type endopeptidase activity GO:0004252 IEA protein binding 18256700 GO:0005515 IPI cysteine-type peptidase activity 8811434 GO:0008234 IDA peptidase activator activity involved in apoptotic process GO:0016505 IEA phosphatase binding 18307834 GO:0019902 ISS chloride ion binding GO:0031404 IEA identical protein binding GO:0042802 IEA protein self-association GO:0043621 IEA chaperone binding 18307834 GO:0051087 ISS,hsa04142 Lysosome - Homo sapiens (human),CHEMBL CHEMBL3261926,P53634,Dipeptidyl peptidase I,1.0,PRIMARY,NO,NC1(CCOCC1)C(=O)N[C@@H](Cc2ccc(cc2)c3ccc(cc3)C#N)C#N,5,8,"InChI=1S/C22H22N4O2/c23-14-17-3-7-19(8-4-17)18-5-1-16(2-6-18)13-20(15-24)26-21(27)22(25)9-11-28-12-10-22/h1-8,20H,9-13,25H2,(H,26,27)/t20-/m0/s1",NNUFRZJZOXVZIT-FQEVSTJZSA-N,"c(""Dipeptidyl peptidase I"", ""Unchecked"", ""Cathepsin L"", ""Cathepsin S"", ""Cathepsin B"", ""Cathepsin K"")",1075,CATC,Adaptive Immune System R-HSA-1280218 Immune System R-HSA-168256 MHC class II antigen presentation R-HSA-2132295,GO:0000139 Golgi membrane IEA GO:0005615 extracellular space 16502470 IDA GO:0005764 lysosome 18307834 ISS GO:0005764 lysosome 7665576 TAS GO:0005788 endoplasmic reticulum lumen TAS GO:0016020 membrane 19946888 IDA GO:0030134 ER to Golgi transport vesicle TAS GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane TAS GO:0070062 extracellular exosome 19056867 19199708 23376485 23533145 IDA,T cell mediated cytotoxicity GO:0001913 IEA proteolysis 8811434 GO:0006508 IDA ER to Golgi vesicle-mediated transport GO:0006888 TAS apoptotic process GO:0006915 IEA immune response 9092576 GO:0006955 TAS aging GO:0007568 IEA response to organic substance GO:0010033 IEA COPII vesicle coating GO:0048208 TAS proteolysis involved in cellular protein catabolic process GO:0051603 IBA positive regulation of proteolysis involved in cellular protein catabolic process 18307834 GO:1903052 ISS positive regulation of apoptotic signaling pathway GO:2001235 IEA,cysteine-type endopeptidase activity GO:0004197 IBA serine-type endopeptidase activity GO:0004252 IEA protein binding 18256700 GO:0005515 IPI cysteine-type peptidase activity 8811434 GO:0008234 IDA peptidase activator activity involved in apoptotic process GO:0016505 IEA phosphatase binding 18307834 GO:0019902 ISS chloride ion binding GO:0031404 IEA identical protein binding GO:0042802 IEA protein self-association GO:0043621 IEA chaperone binding 18307834 GO:0051087 ISS,hsa04142 Lysosome - Homo sapiens (human),CHEMBL CHEMBL376359,P27487,Dipeptidyl peptidase IV,1.0,ORTHOGONAL,NO,CN1C(=O)C=C(N2CCC[C@@H](N)C2)N(Cc3ccccc3C#N)C1=O,6,30,"InChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1",ZSBOMTDTBDDKMP-OAHLLOKOSA-N,"c(""Dipeptidyl peptidase IV"", ""Dipeptidyl peptidase VIII"", ""Dipeptidyl peptidase IX"", ""Fibroblast activation protein alpha"", ""Dipeptidyl peptidase II"", ""Unchecked"", ""Prolyl endopeptidase"")",1803,DPP4,"R-HSA-2980736 Peptide hormone metabolism R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-392499 Metabolism of proteins R-HSA-400508 Incretin synthesis, secretion, and inactivation R-HSA-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)",lysosomal membrane GO:0005765 IDA 17897319 plasma membrane GO:0005886 IDA 16670267 focal adhesion GO:0005925 IDA 21423176 cell surface GO:0009986 IDA 7594462 8101391 10900005 11772392 membrane GO:0016020 IDA 19946888 integral component of membrane GO:0016021 IEA apical plasma membrane GO:0016324 IDA 15052268 lamellipodium GO:0030027 IDA 16651416 endocytic vesicle GO:0030139 IDA 10900005 lamellipodium membrane GO:0031258 IEA membrane raft GO:0045121 IEA intercellular canaliculus GO:0046581 IEA extracellular exosome GO:0070062 IDA 11487543 19056867 19199708 20458337 21362503 23376485 23533145 invadopodium membrane GO:0071438 IDA 16651416,GO:0001662 behavioral fear response IEA 16670267 GO:0001666 response to hypoxia IDA GO:0006508 proteolysis IEA 17549790 GO:0008284 positive regulation of cell proliferation IDA 16651416 GO:0010716 negative regulation of extracellular matrix disassembly IDA 10900005 17287217 GO:0031295 T cell costimulation IDA 11772392 GO:0033632 regulation of cell-cell adhesion mediated by integrin IDA GO:0035641 locomotory exploration behavior IEA GO:0036343 psychomotor behavior IEA 7594462 GO:0042110 T cell activation IDA 16651416 GO:0043542 endothelial cell migration IDA GO:0046718 viral entry into host cell IEA,23486063 GO:0001618 virus receptor activity IDA 16651416 GO:0002020 protease binding IPI GO:0004252 serine-type endopeptidase activity IEA 10900005 GO:0005102 receptor binding IPI 7594462 8101391 14684150 17287217 17549790 18275857 21314817 22001206 GO:0005515 protein binding IPI 14684150 GO:0008236 serine-type peptidase activity IDA 10593948 14684150 16651416 17549790 GO:0008239 dipeptidyl-peptidase activity IDA 22001206 GO:0042802 identical protein binding IPI 14684150 15448155 GO:0042803 protein homodimerization activity IPI,Protein digestion and absorption - Homo sapiens (human) hsa04974,CHEMBL CHEMBL1422,P27487,Dipeptidyl peptidase IV,1.0,PRIMARY,NO,N[C@@H](CC(=O)N1CCn2c(C1)nnc2C(F)(F)F)Cc3cc(F)c(F)cc3F,6,117,"InChI=1S/C16H15F6N5O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27-13(7-26)24-25-15(27)16(20,21)22/h4,6,9H,1-3,5,7,23H2/t9-/m1/s1",MFFMDFFZMYYVKS-SECBINFHSA-N,"c(""Dipeptidyl peptidase IV"", ""Dipeptidyl peptidase VIII"", ""Dipeptidyl peptidase IX"", ""Dipeptidyl peptidase II"", ""Fibroblast activation protein alpha"", ""Homo sapiens"", ""Unchecked"", ""Prolyl endopeptidase"")",1803,DPP4,"R-HSA-2980736 Peptide hormone metabolism R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) R-HSA-392499 Metabolism of proteins R-HSA-400508 Incretin synthesis, secretion, and inactivation R-HSA-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)",lysosomal membrane GO:0005765 IDA 17897319 plasma membrane GO:0005886 IDA 16670267 focal adhesion GO:0005925 IDA 21423176 cell surface GO:0009986 IDA 7594462 8101391 10900005 11772392 membrane GO:0016020 IDA 19946888 integral component of membrane GO:0016021 IEA apical plasma membrane GO:0016324 IDA 15052268 lamellipodium GO:0030027 IDA 16651416 endocytic vesicle GO:0030139 IDA 10900005 lamellipodium membrane GO:0031258 IEA membrane raft GO:0045121 IEA intercellular canaliculus GO:0046581 IEA extracellular exosome GO:0070062 IDA 11487543 19056867 19199708 20458337 21362503 23376485 23533145 invadopodium membrane GO:0071438 IDA 16651416,GO:0001662 behavioral fear response IEA 16670267 GO:0001666 response to hypoxia IDA GO:0006508 proteolysis IEA 17549790 GO:0008284 positive regulation of cell proliferation IDA 16651416 GO:0010716 negative regulation of extracellular matrix disassembly IDA 10900005 17287217 GO:0031295 T cell costimulation IDA 11772392 GO:0033632 regulation of cell-cell adhesion mediated by integrin IDA GO:0035641 locomotory exploration behavior IEA GO:0036343 psychomotor behavior IEA 7594462 GO:0042110 T cell activation IDA 16651416 GO:0043542 endothelial cell migration IDA GO:0046718 viral entry into host cell IEA,23486063 GO:0001618 virus receptor activity IDA 16651416 GO:0002020 protease binding IPI GO:0004252 serine-type endopeptidase activity IEA 10900005 GO:0005102 receptor binding IPI 7594462 8101391 14684150 17287217 17549790 18275857 21314817 22001206 GO:0005515 protein binding IPI 14684150 GO:0008236 serine-type peptidase activity IDA 10593948 14684150 16651416 17549790 GO:0008239 dipeptidyl-peptidase activity IDA 22001206 GO:0042802 identical protein binding IPI 14684150 15448155 GO:0042803 protein homodimerization activity IPI,Protein digestion and absorption - Homo sapiens (human) hsa04974,CHEMBL CHEMBL3344470,P14416,Dopamine D2 receptor,1.0,PRIMARY,NO,COc1cc2CCN3Cc4cc(CCCCCl)sc4C[C@H]3c2cc1O,4,7,"InChI=1S/C20H24ClNO2S/c1-24-19-9-13-5-7-22-12-14-8-15(4-2-3-6-21)25-20(14)11-17(22)16(13)10-18(19)23/h8-10,17,23H,2-7,11-12H2,1H3/t17-/m0/s1",MRYWDVLOYWQXCU-KRWDZBQOSA-N,"c(""Dopamine D1 receptor"", ""Dopamine D2 receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 2a (5-HT2a) receptor"")",1813,DRD2,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Amine ligand-binding receptors R-HSA-375280 GPCR downstream signaling R-HSA-388396 Dopamine receptors R-HSA-390651 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,IEA GO:0001669 acrosomal vesicle IEA GO:0005829 cytosol IDA 26554819 plasma membrane GO:0005886 TAS GO:0005886 plasma membrane IDA 8413587 integral component of plasma membrane GO:0005887 IEA GO:0014069 postsynaptic density IEA GO:0016328 lateral plasma membrane IEA GO:0030139 endocytic vesicle ISS GO:0030424 axon ISS GO:0030425 dendrite IBA GO:0030672 synaptic vesicle membrane IDA 20531939 nonmotile primary cilium GO:0031513 IEA GO:0036126 sperm flagellum IEA GO:0043197 dendritic spine IEA GO:0043204 perikaryon IEA GO:0043679 axon terminus IDA 20531939 ciliary membrane GO:0060170,"temperature homeostasis ISS GO:0001659 response to hypoxia IEA GO:0001666 synaptic transmission, dopaminergic IBA GO:0001963 response to amphetamine ISS GO:0001975 neurological system process involved in regulation of systemic arterial blood pressure ISS GO:0001976 regulation of heart rate ISS GO:0002027 regulation of sodium ion transport ISS GO:0002028 G-protein coupled receptor internalization IEA GO:0002031 positive regulation of neuroblast proliferation ISS GO:0002052 positive regulation of receptor internalization IEA GO:0002092 negative regulation of adenylate cyclase activity IEA GO:0007194 adenylate cyclase-inhibiting dopamine receptor signaling pathway IDA 26554819 GO:0007195 neuron-neuron synaptic transmission ISS GO:0007270 axonogenesis ISS GO:0007409 synapse assembly ISS GO:0007416 sensory perception of smell ISS GO:0007608 long-term memory IEA GO:0007616 grooming behavior IEA GO:0007625 locomotory behavior ISS GO:0007626 adult walking behavior ISS GO:0007628 feeding behavior IEA GO:0007631 protein localization ISS GO:0008104 negative regulation of cell proliferation ISS GO:0008285 associative learning ISS GO:0008306 visual learning ISS GO:0008542 response to light stimulus ISS GO:0009416 response to toxic substance IBA GO:0009636 response to iron ion IEA GO:0010039 regulation of dopamine secretion IBA GO:0014059 response to inactivity IEA GO:0014854 Wnt signaling pathway IEA GO:0016055 striatum development IEA GO:0021756 orbitofrontal cortex development IEA GO:0021769 cerebral cortex GABAergic interneuron migration ISS GO:0021853 adenohypophysis development ISS GO:0021984 negative regulation of cell migration ISS GO:0030336 peristalsis ISS GO:0030432 regulation of cAMP metabolic process IDA 8666994 GO:0030814 auditory behavior IEA GO:0031223 activation of protein kinase activity IEA GO:0032147 regulation of synaptic transmission, GABAergic ISS GO:0032228 positive regulation of cytokinesis IMP 22888021 GO:0032467 circadian regulation of gene expression ISS GO:0032922 negative regulation of dopamine secretion IEA GO:0033602 response to histamine IDA 16839358 GO:0034776 response to nicotine IEA GO:0035094 positive regulation of urine volume IEA GO:0035810 positive regulation of renal sodium excretion IEA GO:0035815 positive regulation of multicellular organism growth IEA GO:0040018 response to cocaine ISS GO:0042220 negative regulation of circadian sleep/wake cycle, sleep IEA GO:0042321 dopamine metabolic process IC 8301582 GO:0042417 response to drug IBA GO:0042493 response to drug ISS GO:0042493 regulation of potassium ion transport IBA GO:0043266 regulation of potassium ion transport ISS GO:0043266 response to morphine ISS GO:0043278 pigmentation IEA GO:0043473 regulation of phosphoprotein phosphatase activity IEA GO:0043666 positive regulation of G-protein coupled receptor protein signaling pathway IEA GO:0045745 negative regulation of blood pressure ISS GO:0045776 negative regulation of innate immune response IEA GO:0045824 positive regulation of transcription from RNA polymerase II promoter IEA GO:0045944 phosphatidylinositol metabolic process ISS GO:0046488 negative regulation of insulin secretion IEA GO:0046676 behavioral response to cocaine IBA GO:0048148 behavioral response to cocaine ISS GO:0048148 behavioral response to ethanol IBA GO:0048149 behavioral response to ethanol ISS GO:0048149 regulation of long-term neuronal synaptic plasticity ISS GO:0048169 response to axon injury IEA GO:0048678 branching morphogenesis of a nerve ISS GO:0048755 arachidonic acid secretion IDA 8301582 GO:0050482 negative regulation of protein secretion IDA 16839358 GO:0050709 release of sequestered calcium ion into cytosol ISS GO:0051209 negative regulation of cytosolic calcium ion concentration IBA GO:0051481 regulation of dopamine uptake involved in synaptic transmission IC 8301582 GO:0051584 positive regulation of dopamine uptake involved in synaptic transmission ISS GO:0051586 regulation of synapse structural plasticity IEA GO:0051823 negative regulation of protein kinase B signaling ISS GO:0051898 negative regulation of protein kinase B signaling NAS 21711983 GO:0051898 negative regulation of synaptic transmission, glutamatergic IBA GO:0051967 negative regulation of synaptic transmission, glutamatergic ISS GO:0051967 positive regulation of growth hormone secretion ISS GO:0060124 prepulse inhibition ISS GO:0060134 phospholipase C-activating dopamine receptor signaling pathway IGI 17194762 GO:0060158 negative regulation of dopamine receptor signaling pathway ISS GO:0060160 positive regulation of ERK1 and ERK2 cascade IEA GO:0070374 NOT adenylate cyclase-activating adrenergic receptor signaling pathway IBA GO:0071880 regulation of locomotion involved in locomotory behavior IEA GO:0090325 chemical synaptic transmission, postsynaptic NAS 21711983 GO:0099565 positive regulation of glial cell-derived neurotrophic factor secretion IDA 23373701 GO:1900168 positive regulation of long-term synaptic potentiation IEA GO:1900273 negative regulation of voltage-gated calcium channel activity IEA GO:1901386","dopamine neurotransmitter receptor activity, coupled via Gi/Go IDA 8301582 GO:0001591 NOT adrenergic receptor activity IBA GO:0004935 protein binding IPI 10692483 17380124 19632986 GO:0005515 drug binding IDA 8413587 GO:0008144 dopamine binding IBA GO:0035240 ionotropic glutamate receptor binding IEA GO:0035255 identical protein binding IPI 18668123 GO:0042802 protein homodimerization activity IEA GO:0042803 protein heterodimerization activity IEA GO:0046982","hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04540 Gap junction - Homo sapiens (human) hsa04728 Dopaminergic synapse - Homo sapiens (human) hsa05012 Parkinson,s disease - Homo sapiens (human) hsa05030 Cocaine addiction - Homo sapiens (human) hsa05034 Alcoholism - Homo sapiens (human)",CHEMBL CHEMBL158627,P35462,Dopamine D3 receptor,1.0,ORTHOGONAL,NO,CS(=O)(=O)Oc1ccc2CN(CC[C@@H]3CC[C@H](CC3)NC(=O)\C=C\c4ccc(F)cc4)Cc2c1,11,12,"InChI=1S/C26H31FN2O4S/c1-34(31,32)33-25-12-7-21-17-29(18-22(21)16-25)15-14-20-4-10-24(11-5-20)28-26(30)13-6-19-2-8-23(27)9-3-19/h2-3,6-9,12-13,16,20,24H,4-5,10-11,14-15,17-18H2,1H3,(H,28,30)/b13-6+/t20-,24-",WUACSCWYLJHDBV-HNNHSTSXSA-N,"c(""Dopamine D3 receptor"", ""Dopamine D2 receptor"", ""Dopamine receptors; D2 & D3"", ""Serotonin 1d (5-HT1d) receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 2b (5-HT2b) receptor"", ""Serotonin 2c (5-HT2c) receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Serotonin 7 (5-HT7) receptor"", ""Alpha-1b adrenergic receptor"")",1814,DRD3,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Amine ligand-binding receptors R-HSA-375280 GPCR downstream signaling R-HSA-388396 Dopamine receptors R-HSA-390651 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,16386234 18424554 20531939 IDA GO:0005886 plasma membrane TAS GO:0005886 plasma membrane 8301582 IC GO:0005887 integral component of plasma membrane 8413587 IDA GO:0005887 integral component of plasma membrane IEA GO:0030139 endocytic vesicle IEA GO:0042995 cell projection IEA GO:0045177 apical part of cell,"GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0001963 synaptic transmission, dopaminergic IBA GO:0001975 response to amphetamine IEA GO:0002016 regulation of blood volume by renin-angiotensin IEA GO:0002031 G-protein coupled receptor internalization 18424554 IDA GO:0006874 cellular calcium ion homeostasis 7911712 IDA GO:0007186 G-protein coupled receptor signaling pathway 7911712 IDA GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway 18424554 IDA GO:0007194 negative regulation of adenylate cyclase activity 7907363 IDA GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway 7907363 18424554 IDA GO:0007611 learning or memory 14681904 NAS GO:0007612 learning 15998189 NAS GO:0007626 locomotory behavior ISS GO:0008284 positive regulation of cell proliferation IEA GO:0008542 visual learning ISS GO:0014059 regulation of dopamine secretion ISS GO:0019216 regulation of lipid metabolic process IEA GO:0030814 regulation of cAMP metabolic process 8666994 IDA GO:0032416 negative regulation of sodium:proton antiporter activity IEA GO:0032467 positive regulation of cytokinesis 22888021 IMP GO:0032922 circadian regulation of gene expression ISS GO:0034776 response to histamine 16839358 IDA GO:0035176 social behavior 12860355 NAS GO:0035483 gastric emptying IEA GO:0035815 positive regulation of renal sodium excretion IEA GO:0040014 regulation of multicellular organism growth IEA GO:0042220 response to cocaine 10415668 IEP GO:0042417 dopamine metabolic process 8301582 IC GO:0042493 response to drug ISS GO:0043278 response to morphine ISS GO:0045187 regulation of circadian sleep/wake cycle, sleep IEA GO:0045471 response to ethanol NOT ISS GO:0045776 negative regulation of blood pressure ISS GO:0045840 positive regulation of mitotic nuclear division ISS GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0046717 acid secretion ISS GO:0048148 behavioral response to cocaine 8815892 IEP GO:0048148 behavioral response to cocaine ISS GO:0048715 negative regulation of oligodendrocyte differentiation ISS GO:0050482 arachidonic acid secretion 8301582 IDA GO:0050709 negative regulation of protein secretion 16839358 IDA GO:0050883 musculoskeletal movement, spinal reflex action ISS GO:0051584 regulation of dopamine uptake involved in synaptic transmission 8301582 IC GO:0051898 negative regulation of protein kinase B signaling ISS GO:0060134 prepulse inhibition 18325483 IMP GO:0060160 negative regulation of dopamine receptor signaling pathway IEA GO:0060161 positive regulation of dopamine receptor signaling pathway ISS GO:0090325 regulation of locomotion involved in locomotory behavior IEA","GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs IBA GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go 8301582 IDA GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go ISS GO:0005515 protein binding 10692483 16386234 18424554 26460884 IPI GO:0008144 drug binding 8413587 IDA GO:0008144 drug binding ISS GO:0019904 protein domain specific binding IEA GO:0031748 D1 dopamine receptor binding IEA GO:0035240 dopamine binding IBA",Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Dopaminergic synapse - Homo sapiens (human) hsa04728,CHEMBL CHEMBL244946,P35462,Dopamine D3 receptor,1.0,PRIMARY,NO,Cc1ccc2c(cccc2n1)c3nnc(SCCCN4CCc5ccc(cc5CC4)c6cc(C)nn6C)n3C,15,61,"InChI=1S/C31H35N7S/c1-21-9-12-26-27(7-5-8-28(26)32-21)30-33-34-31(36(30)3)39-18-6-15-38-16-13-23-10-11-25(20-24(23)14-17-38)29-19-22(2)35-37(29)4/h5,7-12,19-20H,6,13-18H2,1-4H3",WIHMMKGUBDZGEG-UHFFFAOYSA-N,"c(""Dopamine D3 receptor"", ""Dopamine D2 receptor"", ""Histamine H1 receptor"", ""Angiotensin II type 2 (AT-2) receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 2c (5-HT2c) receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Serotonin 1d (5-HT1d) receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Serotonin 7 (5-HT7) receptor"", ""Adenosine A1 receptor"", ""Adenosine A2a receptor"", ""Adenosine A2b receptor"", ""Alpha-1a adrenergic receptor"", ""Alpha-1b adrenergic receptor"", ""Histamine H3 receptor"", ""Muscarinic acetylcholine receptor M1"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M4"", ""Muscarinic acetylcholine receptor M5"", ""Beta-2 adrenergic receptor"", ""Calcitonin gene-related peptide type 1 receptor"", ""Cannabinoid CB1 receptor"", ""Dopamine D1 receptor"", ""Dopamine D4 receptor"", ""Dopamine D5 receptor"", ""Endothelin receptor ET-B"", ""Unchecked"", ""Serotonin 3a (5-HT3a) receptor"", ""Estrogen receptor beta"", ""Progesterone receptor"", ""Mu opioid receptor"")",1814,DRD3,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Amine ligand-binding receptors R-HSA-375280 GPCR downstream signaling R-HSA-388396 Dopamine receptors R-HSA-390651 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,16386234 18424554 20531939 IDA GO:0005886 plasma membrane TAS GO:0005886 plasma membrane 8301582 IC GO:0005887 integral component of plasma membrane 8413587 IDA GO:0005887 integral component of plasma membrane IEA GO:0030139 endocytic vesicle IEA GO:0042995 cell projection IEA GO:0045177 apical part of cell,"GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0001963 synaptic transmission, dopaminergic IBA GO:0001975 response to amphetamine IEA GO:0002016 regulation of blood volume by renin-angiotensin IEA GO:0002031 G-protein coupled receptor internalization 18424554 IDA GO:0006874 cellular calcium ion homeostasis 7911712 IDA GO:0007186 G-protein coupled receptor signaling pathway 7911712 IDA GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway 18424554 IDA GO:0007194 negative regulation of adenylate cyclase activity 7907363 IDA GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway 7907363 18424554 IDA GO:0007611 learning or memory 14681904 NAS GO:0007612 learning 15998189 NAS GO:0007626 locomotory behavior ISS GO:0008284 positive regulation of cell proliferation IEA GO:0008542 visual learning ISS GO:0014059 regulation of dopamine secretion ISS GO:0019216 regulation of lipid metabolic process IEA GO:0030814 regulation of cAMP metabolic process 8666994 IDA GO:0032416 negative regulation of sodium:proton antiporter activity IEA GO:0032467 positive regulation of cytokinesis 22888021 IMP GO:0032922 circadian regulation of gene expression ISS GO:0034776 response to histamine 16839358 IDA GO:0035176 social behavior 12860355 NAS GO:0035483 gastric emptying IEA GO:0035815 positive regulation of renal sodium excretion IEA GO:0040014 regulation of multicellular organism growth IEA GO:0042220 response to cocaine 10415668 IEP GO:0042417 dopamine metabolic process 8301582 IC GO:0042493 response to drug ISS GO:0043278 response to morphine ISS GO:0045187 regulation of circadian sleep/wake cycle, sleep IEA GO:0045471 response to ethanol NOT ISS GO:0045776 negative regulation of blood pressure ISS GO:0045840 positive regulation of mitotic nuclear division ISS GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0046717 acid secretion ISS GO:0048148 behavioral response to cocaine 8815892 IEP GO:0048148 behavioral response to cocaine ISS GO:0048715 negative regulation of oligodendrocyte differentiation ISS GO:0050482 arachidonic acid secretion 8301582 IDA GO:0050709 negative regulation of protein secretion 16839358 IDA GO:0050883 musculoskeletal movement, spinal reflex action ISS GO:0051584 regulation of dopamine uptake involved in synaptic transmission 8301582 IC GO:0051898 negative regulation of protein kinase B signaling ISS GO:0060134 prepulse inhibition 18325483 IMP GO:0060160 negative regulation of dopamine receptor signaling pathway IEA GO:0060161 positive regulation of dopamine receptor signaling pathway ISS GO:0090325 regulation of locomotion involved in locomotory behavior IEA","GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs IBA GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go 8301582 IDA GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go ISS GO:0005515 protein binding 10692483 16386234 18424554 26460884 IPI GO:0008144 drug binding 8413587 IDA GO:0008144 drug binding ISS GO:0019904 protein domain specific binding IEA GO:0031748 D1 dopamine receptor binding IEA GO:0035240 dopamine binding IBA",Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Dopaminergic synapse - Homo sapiens (human) hsa04728,CHEMBL CHEMBL267014,P21917,Dopamine D4 receptor,1.0,PRIMARY,NO,Clc1ccc(cc1)N2CCN(Cc3c[nH]c4ncccc34)CC2,21,89,"InChI=1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21)",OGJGQVFWEPNYSB-UHFFFAOYSA-N,"c(""Dopamine D2 receptor"", ""Dopamine D3 receptor"", ""Dopamine D4 receptor"", ""Dopamine receptors; D2 & D4"", ""Sigma opioid receptor"", ""Serotonin 2 (5-HT2) receptor"", ""Voltage-gated L-type calcium channel"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Serotonin 7 (5-HT7) receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Serotonin 1d (5-HT1d) receptor"", ""Serotonin 1e (5-HT1e) receptor"", ""Serotonin 2c (5-HT2c) receptor"", ""Serotonin 5a (5-HT5a) receptor"", ""Kappa opioid receptor"", ""Delta opioid receptor"", ""Mu opioid receptor"", ""Histamine H1 receptor"", ""Glutamate [NMDA] receptor"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M4"", ""Muscarinic acetylcholine receptor M5"", ""Unchecked"", ""Dopamine receptors; D2 & D3"", ""Nuclear factor NF-kappa-B p105 subunit"", ""Thyroid stimulating hormone receptor"", ""Hypoxia-inducible factor 1 alpha"", ""Arachidonate 15-lipoxygenase"", ""ATPase family AAA domain-containing protein 5"", ""Dopamine D1 receptor"", ""Histone-lysine N-methyltransferase, H3 lysine-9 specific 3"", ""Arachidonate 15-lipoxygenase, type II"", ""Ataxin-2"", ""Ubiquitin carboxyl-terminal hydrolase 1"", ""Flap endonuclease 1"", ""DNA polymerase kappa"")",1815,DRD4,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375280 Amine ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-390651 Dopamine receptors R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,plasma membrane GO:0005886 20531939 IDA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 8413587 9843378 15755724 IDA cell cortex GO:0005938 IEA vesicle membrane GO:0012506 IEA membrane GO:0016020 7512953 IDA neuronal cell body GO:0043025 IEA terminal bouton GO:0043195 IEA dendritic spine GO:0043197 IEA,"activation of MAPK activity GO:0000187 IDA 9843378 15755724 behavioral fear response GO:0001662 NAS 12860355 synaptic transmission, dopaminergic GO:0001963 IBA response to amphetamine GO:0001975 ISS cellular calcium ion homeostasis GO:0006874 IC 7921596 negative regulation of adenylate cyclase activity GO:0007194 IDA 7512953 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 IDA 7512953 dopamine receptor signaling pathway GO:0007212 IDA 1840645 short-term memory GO:0007614 IEA circadian rhythm GO:0007623 IEA adult locomotory behavior GO:0008344 ISS olfactory learning GO:0008355 IEA photoperiodism GO:0009648 IEA negative regulation of cAMP biosynthetic process GO:0030818 IDA 7512953 9843378 positive regulation of sodium:proton antiporter activity GO:0032417 IDA 7512953 positive regulation of kinase activity GO:0033674 IDA 15755724 response to histamine GO:0034776 IDA 16839358 social behavior GO:0035176 NAS 11126393 11409696 regulation of dopamine metabolic process GO:0042053 ISS dopamine metabolic process GO:0042417 IC 1840645 fear response GO:0042596 ISS regulation of circadian rhythm GO:0042752 ISS regulation of neurotransmitter secretion GO:0046928 IEA behavioral response to cocaine GO:0048148 ISS behavioral response to ethanol GO:0048149 TAS 12888781 response to steroid hormone GO:0048545 IEA arachidonic acid secretion GO:0050482 IDA 7512953 negative regulation of protein secretion GO:0050709 IDA 16839358 regulation of calcium-mediated signaling GO:0050848 IEA positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 IC 1840645 retina development in camera-type eye GO:0060041 IEA inhibitory postsynaptic potential GO:0060080 ISS positive regulation of penile erection GO:0060406 IEA negative regulation of voltage-gated calcium channel activity GO:1901386 IDA 7921596 positive regulation of excitatory postsynaptic potential GO:2000463 IEA","dopamine neurotransmitter receptor activity, coupled via Gs GO:0001588 IBA dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 IDA 1840645 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 ISS dopamine neurotransmitter receptor activity GO:0004952 IDA 8413587 protein binding GO:0005515 IPI 12297500 drug binding GO:0008144 IDA 1319557 1840645 8413587 potassium channel regulator activity GO:0015459 NAS 12297500 SH3 domain binding GO:0017124 IDA 9843378 dopamine binding GO:0035240 IDA 1319557 identical protein binding GO:0042802 IPI 21320289",Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Dopaminergic synapse - Homo sapiens (human) hsa04728,CHEMBL CHEMBL1643901,Q01959,Dopamine transporter,1.0,PRIMARY,NO,CN(Cc1cccc(F)c1)[C@H]2C3C4CC5C6C4CC3C6C25,40,87,"InChI=1S/C19H22FN/c1-21(8-9-3-2-4-10(20)5-9)19-16-12-7-13-15-11(12)6-14(16)17(15)18(13)19/h2-5,11-19H,6-8H2,1H3/t11?,12?,13?,14?,15?,16?,17?,18?,19-/m0/s1",GACBJAOXQGFNDL-RAOGCBAWSA-N,"c(""Dopamine transporter"", ""Unchecked"", ""Norepinephrine transporter"", ""Serotonin transporter"", ""Dopamine D5 receptor"", ""Alpha-1a adrenergic receptor"", ""Alpha-1b adrenergic receptor"", ""Alpha-1d adrenergic receptor"", ""Alpha-2a adrenergic receptor"", ""Alpha-2b adrenergic receptor"", ""Alpha-2c adrenergic receptor"", ""Beta-1 adrenergic receptor"", ""Beta-2 adrenergic receptor"", ""Beta-3 adrenergic receptor"", ""Dopamine D1 receptor"", ""Dopamine D2 receptor"", ""Dopamine D3 receptor"", ""Dopamine D4 receptor"", ""Histamine H2 receptor"", ""Histamine H3 receptor"", ""Histamine H4 receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Serotonin 1d (5-HT1d) receptor"", ""Serotonin 1e (5-HT1e) receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 2b (5-HT2b) receptor"", ""Serotonin 2c (5-HT2c) receptor"", ""Serotonin 3a (5-HT3a) receptor"", ""Serotonin 5a (5-HT5a) receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Serotonin 7 (5-HT7) receptor"", ""Muscarinic acetylcholine receptor M1"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M4"", ""Muscarinic acetylcholine receptor M5"", ""Delta opioid receptor"", ""Kappa opioid receptor"", ""Mu opioid receptor"", ""GABA-A receptor; agonist GABA site"", ""Histamine H1 receptor"")",6531,SC6A3,"Neurotransmitter Clearance In The Synaptic Cleft R-HSA-112311 Transmission across Chemical Synapses R-HSA-112315 Neuronal System R-HSA-112316 Dopamine clearance from the synaptic cleft R-HSA-379401 Transmembrane transport of small molecules R-HSA-382551 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds R-HSA-425366 SLC-mediated transmembrane transport R-HSA-425407 Amine compound SLC transporters R-HSA-425428 Na+/Cl- dependent neurotransmitter transporters R-HSA-442660",cytoplasm 10823899 GO:0005737 TAS plasma membrane 11343649 12958153 GO:0005886 IDA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 IBA cell surface 21399631 GO:0009986 IDA integral component of membrane 8628395 GO:0016021 TAS flotillin complex 21399631 GO:0016600 IDA axon 12958153 GO:0030424 IDA neuronal cell body 12958153 GO:0043025 IDA presynapse GO:0098793 IEA,IEA GO:0007568 aging IEA GO:0007595 lactation IEA GO:0007608 sensory perception of smell IEA GO:0007626 locomotory behavior IEA GO:0010039 response to iron ion IDA 16024787 monoamine transport GO:0015844 IDA 15505207 dopamine transport GO:0015872 IEA GO:0021984 adenohypophysis development IEA GO:0035094 response to nicotine IEA GO:0040018 positive regulation of multicellular organism growth IEA GO:0042053 regulation of dopamine metabolic process TAS GO:0042136 neurotransmitter biosynthetic process IEA GO:0042220 response to cocaine IEA GO:0042416 dopamine biosynthetic process IEA GO:0042420 dopamine catabolic process IEA GO:0042493 response to drug IEA GO:0045471 response to ethanol IBA GO:0051583 dopamine uptake involved in synaptic transmission IEA GO:0051591 response to cAMP IEA GO:0060134 prepulse inhibition IEA GO:0072488 ammonium transmembrane transport,IEA GO:0002020 protease binding IEA GO:0005102 receptor binding IDA 15505207 dopamine transmembrane transporter activity GO:0005329 IBA GO:0005330 dopamine:sodium symporter activity IPI 11343649 12958153 15505207 17380124 22163275 protein binding GO:0005515 IEA GO:0008144 drug binding IDA 16024787 monoamine transmembrane transporter activity GO:0008504 TAS GO:0008504 monoamine transmembrane transporter activity IEA GO:0032403 protein complex binding IEA GO:0035240 dopamine binding IEA GO:0046872 metal ion binding IEA GO:0047485 protein N-terminus binding IEA GO:0051721 protein phosphatase 2A binding,"hsa04728 Dopaminergic synapse - Homo sapiens (human) hsa05012 Parkinson,s disease - Homo sapiens (human) hsa05030 Cocaine addiction - Homo sapiens (human) hsa05031 Amphetamine addiction - Homo sapiens (human) hsa05034 Alcoholism - Homo sapiens (human)",CHEMBL CHEMBL3410084,P33981,Dual specificity protein kinase TTK,1.0,ORTHOGONAL,NO,CC(C)(Nc1cc(NCC2CCOCC2)c3ncc(c4ccc(cc4)C(=O)NC5CC5)n3n1)C(F)(F)F,3,21,"InChI=1S/C26H31F3N6O2/c1-25(2,26(27,28)29)33-22-13-20(30-14-16-9-11-37-12-10-16)23-31-15-21(35(23)34-22)17-3-5-18(6-4-17)24(36)32-19-7-8-19/h3-6,13,15-16,19,30H,7-12,14H2,1-2H3,(H,32,36)(H,33,34)",LVBWRNKEBGYENR-UHFFFAOYSA-N,"c(""Dual specificity protein kinase TTK"", ""A549"", ""NCI-H460"", ""NCI-H358"", ""Unchecked"", ""HT-29"", ""CaM kinase I alpha"", ""Dual specificity protein kinase CLK2"")",7272,TTK,,spindle GO:0005819 10366450 TAS membrane GO:0016020 19946888 IDA,spindle organization TAS 10366450 GO:0007051 mitotic spindle organization TAS 7737118 GO:0007052 mitotic spindle assembly checkpoint TAS 10366450 GO:0007094 positive regulation of cell proliferation TAS 1639825 GO:0008284 positive regulation of pathway-restricted SMAD protein phosphorylation TAS 19018011 GO:0010862 peptidyl-tyrosine phosphorylation IEA GO:0018108 chromosome separation IEA GO:0051304,GO:0004674 protein serine/threonine kinase activity IEA GO:0004712 protein serine/threonine/tyrosine kinase activity IEA GO:0004713 protein tyrosine kinase activity IEA GO:0005515 protein binding 19273613 IPI GO:0005524 ATP binding IEA,Cell cycle - Homo sapiens (human) hsa04110,CHEMBL CHEMBL3109933,P33981,Dual specificity protein kinase TTK,1.0,PRIMARY,NO,CN(C)C(=O)c1ccc(Nc2cc3c(cn2)cc(c4cnn(C)c4)n3C(=O)OC(C)(C)C)c(Cl)c1,4,7,"InChI=1S/C25H27ClN6O3/c1-25(2,3)35-24(34)32-20(17-13-28-31(6)14-17)10-16-12-27-22(11-21(16)32)29-19-8-7-15(9-18(19)26)23(33)30(4)5/h7-14H,1-6H3,(H,27,29)",KYBALIQJYSWGLI-UHFFFAOYSA-N,"c(""Serine/threonine-protein kinase Aurora-A"", ""HCT-116"", ""Dual specificity protein kinase TTK"", ""Serine/threonine-protein kinase PLK1"", ""Serine/threonine-protein kinase NEK2"", ""CDK2/Cyclin A"")",7272,TTK,,spindle GO:0005819 10366450 TAS membrane GO:0016020 19946888 IDA,spindle organization TAS 10366450 GO:0007051 mitotic spindle organization TAS 7737118 GO:0007052 mitotic spindle assembly checkpoint TAS 10366450 GO:0007094 positive regulation of cell proliferation TAS 1639825 GO:0008284 positive regulation of pathway-restricted SMAD protein phosphorylation TAS 19018011 GO:0010862 peptidyl-tyrosine phosphorylation IEA GO:0018108 chromosome separation IEA GO:0051304,GO:0004674 protein serine/threonine kinase activity IEA GO:0004712 protein serine/threonine/tyrosine kinase activity IEA GO:0004713 protein tyrosine kinase activity IEA GO:0005515 protein binding 19273613 IPI GO:0005524 ATP binding IEA,Cell cycle - Homo sapiens (human) hsa04110,CHEMBL CHEMBL3589662,Q13627,Dual-specificity tyrosine-phosphorylation regulated kinase 1A,1.0,PRIMARY,NO,OC(=O)c1nc2ccccc2c3[nH]c4c(I)cccc4c13,7,12,"InChI=1S/C16H9IN2O2/c17-10-6-3-5-9-12-14(19-13(9)10)8-4-1-2-7-11(8)18-15(12)16(20)21/h1-7,19H,(H,20,21)",SDRAETFVRBBLOB-UHFFFAOYSA-N,"c(""Unchecked"", ""Cyclin-dependent kinase 2"", ""Cyclin-dependent kinase 5"", ""Dual-specificity tyrosine-phosphorylation regulated kinase 1A"", ""Cyclin-dependent kinase 9"", ""Dual specificity tyrosine-phosphorylation-regulated kinase 1B"", ""Dual-specificity tyrosine-phosphorylation regulated kinase 2"", ""Dual-specificity tyrosine-phosphorylation regulated kinase 3"")",1859,DYR1A,"R-HSA-1538133 G0 and Early G1 R-HSA-1640170 Cell Cycle R-HSA-453279 Mitotic G1-G1/S phases R-HSA-69278 Cell Cycle, Mitotic",GO:0005634 nucleus ISS GO:0005654 nucleoplasm TAS GO:0016607 nuclear speck ISS GO:0030529 intracellular ribonucleoprotein complex IEA,"IEA GO:0000381 regulation of alternative mRNA splicing, via spliceosome ISS GO:0006468 protein phosphorylation 8769099 TAS GO:0007399 nervous system development ISS GO:0007623 circadian rhythm IEA GO:0018105 peptidyl-serine phosphorylation 20736167 ISS GO:0018107 peptidyl-threonine phosphorylation 9748265 IDA GO:0018108 peptidyl-tyrosine phosphorylation ISS GO:0018108 peptidyl-tyrosine phosphorylation 20736167 ISS GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator ISS GO:0046777 protein autophosphorylation IEA GO:0048025 negative regulation of mRNA splicing, via spliceosome 20736167 ISS GO:0090312 positive regulation of protein deacetylation",TAS GO:0004672 protein kinase activity 20736167 ISS GO:0004674 protein serine/threonine kinase activity IEA GO:0004712 protein serine/threonine/tyrosine kinase activity ISS GO:0004713 protein tyrosine kinase activity 9748265 IDA GO:0004715 non-membrane spanning protein tyrosine kinase activity 14500717 14593110 20736167 20940704 23602568 IPI GO:0005515 protein binding IEA GO:0005524 ATP binding IEA GO:0042802 identical protein binding ISS GO:0043621 protein self-association 20736167 ISS GO:0048156 tau protein binding,,CHEMBL CHEMBL3421968,Q9Y463,Dual specificity tyrosine-phosphorylation-regulated kinase 1B,1.0,PRIMARY,NO,COc1cc(ccc1Nc2nccc(n2)c3cn(C)c4cnccc34)N5CCN(C)CC5,4,5,"InChI=1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)",ZYVXTMKTGDARKR-UHFFFAOYSA-N,"c(""Dual specificity tyrosine-phosphorylation-regulated kinase 1B"", ""Insulin-like growth factor I receptor"", ""Cyclin-dependent kinase 2"", ""Dual-specificity tyrosine-phosphorylation regulated kinase 1A"")",9149,DYR1B,,nucleus GO:0005634 IEA,"protein phosphorylation GO:0006468 11980910 IDA myoblast fusion GO:0007520 IEA peptidyl-tyrosine phosphorylation GO:0018108 IEA positive regulation of transcription, DNA-templated GO:0045893 11980910 IDA adipose tissue development GO:0060612 24827035 IMP",11980910 IDA GO:0003713 transcription coactivator activity 11980910 IDA GO:0004672 protein kinase activity IEA GO:0004674 protein serine/threonine kinase activity IEA GO:0004712 protein serine/threonine/tyrosine kinase activity IEA GO:0004713 protein tyrosine kinase activity 11980910 14500717 14593110 20940704 23602568 IPI GO:0005515 protein binding IEA GO:0005524 ATP binding,,CHEMBL CHEMBL449121,Q9H5J4,Elongation of very long chain fatty acids protein 6,1.0,PRIMARY,NO,CC1=C(C(=O)N(N1)c2ccc(OC(F)(F)F)cc2)C3(C(=O)N(C4=C3C(=O)CC(C)(C)C4)c5ccccc5)C(F)(F)F,5,7,"InChI=1S/C28H23F6N3O4/c1-15-21(23(39)37(35-15)17-9-11-18(12-10-17)41-28(32,33)34)26(27(29,30)31)22-19(13-25(2,3)14-20(22)38)36(24(26)40)16-7-5-4-6-8-16/h4-12,35H,13-14H2,1-3H3",XLEVMSDNWOWFNX-UHFFFAOYSA-N,"c(""Elongation of very long chain fatty acids protein 6"", ""Elongation of very long chain fatty acids protein 3"", ""Elongation of very long chain fatty acids protein 1"", ""Elongation of very long chain fatty acids protein 2"", ""Elongation of very long chain fatty acids protein 5"", ""Unchecked"")",79071,ELOV6,"R-HSA-1430728 Metabolism R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-2426168 Activation of gene expression by SREBF (SREBP) R-HSA-535734 Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-75105 Fatty Acyl-CoA Biosynthesis R-HSA-75109 Triglyceride Biosynthesis R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs",endoplasmic reticulum IDA 20937905 GO:0005783 endoplasmic reticulum membrane TAS GO:0005789 integral component of endoplasmic reticulum membrane IEA GO:0030176,"fatty acid elongation, saturated fatty acid GO:0019367 20937905 IDA long-chain fatty-acyl-CoA biosynthetic process GO:0035338 TAS long-chain fatty acid biosynthetic process GO:0042759 20937905 IDA",protein binding GO:0005515 20937905 IPI fatty acid elongase activity GO:0009922 TAS,hsa00062 Fatty acid elongation - Homo sapiens (human) hsa01040 Biosynthesis of unsaturated fatty acids - Homo sapiens (human),CHEMBL CHEMBL3426787,P14625,Endoplasmin,1.0,PRIMARY,NO,COC(=O)c1c(O)cc(O)c(Cl)c1CCc2nccn2Cc3ccccc3,2,5,"InChI=1S/C20H19ClN2O4/c1-27-20(26)18-14(19(21)16(25)11-15(18)24)7-8-17-22-9-10-23(17)12-13-5-3-2-4-6-13/h2-6,9-11,24-25H,7-8,12H2,1H3",NCWIQXPFJORNJP-UHFFFAOYSA-N,"c(""Heat shock protein HSP 90-alpha"", ""Endoplasmin"", ""Unchecked"")",7184,ENPL,Trafficking and processing of endosomal TLR R-HSA-1679131 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Toll-Like Receptors Cascades R-HSA-168898 Binding and Uptake of Ligands by Scavenger Receptors R-HSA-2173782 Scavenging by Class A Receptors R-HSA-3000480 Vesicle-mediated transport R-HSA-5653656,GO:0005576 extracellular region TAS GO:0005634 nucleus 21630459 IDA GO:0005783 endoplasmic reticulum IDA GO:0005783 endoplasmic reticulum 16130169 TAS GO:0005788 endoplasmic reticulum lumen 10497210 IDA GO:0005788 endoplasmic reticulum lumen TAS GO:0005789 endoplasmic reticulum membrane 10497210 IDA GO:0005829 cytosol 9596688 IDA GO:0005886 plasma membrane IEA GO:0005925 focal adhesion 21423176 IDA GO:0016020 membrane 19946888 IDA GO:0030496 midbody 15166316 IDA GO:0031012 extracellular matrix 23658023 IDA GO:0034663 endoplasmic reticulum chaperone complex IEA GO:0042470 melanosome IEA GO:0048471 perinuclear region of cytoplasm 10497210 IDA GO:0070062 extracellular exosome 19199708 20458337 IDA GO:0071682 endocytic vesicle lumen TAS,"response to hypoxia 15620698 GO:0001666 IDA toll-like receptor signaling pathway GO:0002224 TAS receptor-mediated endocytosis GO:0006898 TAS protein transport 15845869 GO:0015031 NAS ER-associated ubiquitin-dependent protein catabolic process 18264092 GO:0030433 IMP retrograde protein transport, ER to cytosol 25660456 GO:0030970 IMP actin rod assembly 19000834 GO:0031247 IDA protein folding in endoplasmic reticulum 22013210 GO:0034975 TAS response to endoplasmic reticulum stress 22934019 GO:0034976 TAS ATF6-mediated unfolded protein response GO:0036500 TAS negative regulation of apoptotic process 10497210 15192333 GO:0043066 IMP negative regulation of apoptotic process 16130169 GO:0043066 TAS regulation of phosphoprotein phosphatase activity 19000834 GO:0043666 IDA sequestering of calcium ion 15192333 GO:0051208 NAS cellular response to ATP 19000834 GO:0071318 IDA",RNA binding 11958450 GO:0003723 IDA calcium ion binding 10497210 GO:0005509 TAS protein binding 9596688 11907036 15845869 18264092 GO:0005515 IPI ATP binding GO:0005524 IEA protein phosphatase binding 19000834 GO:0019903 IDA virion binding 11958450 GO:0046790 IPI low-density lipoprotein particle receptor binding 15082773 GO:0050750 IDA unfolded protein binding GO:0051082 IEA,hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human) hsa04915 Estrogen signaling pathway - Homo sapiens (human) hsa04918 Thyroid hormone synthesis - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human),CHEMBL CHEMBL191879,P42892,Endothelin-converting enzyme 1,1.0,ORTHOGONAL,NO,CC(=O)S[C@@H]1C[C@@H](COCc2cc(F)c(F)cc2F)N(C1)C(=O)Oc3cccc4OCCOc34,3,6,"InChI=1S/C23H22F3NO6S/c1-13(28)34-16-8-15(12-30-11-14-7-18(25)19(26)9-17(14)24)27(10-16)23(29)33-21-4-2-3-20-22(21)32-6-5-31-20/h2-4,7,9,15-16H,5-6,8,10-12H2,1H3/t15-,16+/m0/s1",VILIDDZBEXSSLV-JKSUJKDBSA-N,"c(""Endothelin-converting enzyme 1"", ""Angiotensin-converting enzyme"", ""Neprilysin"", ""Unchecked"")",1889,ECE1,,lysosomal membrane GO:0005765 IDA 17897319 endosome GO:0005768 IDA 18039931 early endosome GO:0005769 IEA external side of plasma membrane GO:0009897 IDA 9449382 9710124 membrane GO:0016020 IDA 19946888 integral component of membrane GO:0016021 IDA 7805846 intrinsic component of endosome membrane GO:0031302 TAS 18039931 vesicle GO:0031982 ISS 9449382 Weibel-Palade body GO:0033093 IDA 9710124 perinuclear region of cytoplasm GO:0048471 IDA 9710124 extracellular exosome GO:0070062 IDA 19056867,GO:0001666 response to hypoxia IEA 18039931 GO:0001921 positive regulation of receptor recycling IMP 7805846 GO:0003100 regulation of systemic arterial blood pressure by endothelin IC GO:0006915 apoptotic process IEA 9915973 GO:0007507 heart development IMP GO:0010613 positive regulation of cardiac muscle hypertrophy IEA 18039931 GO:0010814 substance P catabolic process IDA 18039931 GO:0010815 bradykinin catabolic process IDA 18039931 GO:0010816 calcitonin catabolic process IDA 7805846 GO:0016485 protein processing IDA 7864876 GO:0016486 peptide hormone processing IDA 7805846 GO:0019229 regulation of vasoconstriction IC GO:0030819 positive regulation of cAMP biosynthetic process IEA 7805846 GO:0034959 endothelin maturation IDA GO:0035994 response to muscle stretch IEA GO:0042312 regulation of vasodilation IEA 7864876 GO:0042447 hormone catabolic process IDA GO:0042493 response to drug IEA 9915973 GO:0042733 embryonic digit morphogenesis IMP 9915973 GO:0043583 ear development IMP GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway IEA GO:0046686 response to cadmium ion IEA GO:0060037 pharyngeal system development IEA GO:0070372 regulation of ERK1 and ERK2 cascade IEA,7805846 18039931 GO:0004175 endopeptidase activity IDA 8062389 GO:0004222 metalloendopeptidase activity ISS 25416956 GO:0005515 protein binding IPI 7864876 GO:0017046 peptide hormone binding IC 7805846 GO:0042803 protein homodimerization activity IPI GO:0046872 metal ion binding IEA,,CHEMBL CHEMBL367315,P42892,Endothelin-converting enzyme 1,1.0,PRIMARY,NO,O=C1C=C(Oc2ccccc12)N3CCOCC3,5,12,"InChI=1S/C13H13NO3/c15-11-9-13(14-5-7-16-8-6-14)17-12-4-2-1-3-10(11)12/h1-4,9H,5-8H2",QNFWERYZJLBANZ-UHFFFAOYSA-N,"c(""Unchecked"", ""DNA-dependent protein kinase"", ""Heat shock protein HSP 90-alpha"", ""Endothelin-converting enzyme 1"", ""Angiotensin-converting enzyme"", ""Neprilysin"")",1889,ECE1,,lysosomal membrane GO:0005765 IDA 17897319 endosome GO:0005768 IDA 18039931 early endosome GO:0005769 IEA external side of plasma membrane GO:0009897 IDA 9449382 9710124 membrane GO:0016020 IDA 19946888 integral component of membrane GO:0016021 IDA 7805846 intrinsic component of endosome membrane GO:0031302 TAS 18039931 vesicle GO:0031982 ISS 9449382 Weibel-Palade body GO:0033093 IDA 9710124 perinuclear region of cytoplasm GO:0048471 IDA 9710124 extracellular exosome GO:0070062 IDA 19056867,GO:0001666 response to hypoxia IEA 18039931 GO:0001921 positive regulation of receptor recycling IMP 7805846 GO:0003100 regulation of systemic arterial blood pressure by endothelin IC GO:0006915 apoptotic process IEA 9915973 GO:0007507 heart development IMP GO:0010613 positive regulation of cardiac muscle hypertrophy IEA 18039931 GO:0010814 substance P catabolic process IDA 18039931 GO:0010815 bradykinin catabolic process IDA 18039931 GO:0010816 calcitonin catabolic process IDA 7805846 GO:0016485 protein processing IDA 7864876 GO:0016486 peptide hormone processing IDA 7805846 GO:0019229 regulation of vasoconstriction IC GO:0030819 positive regulation of cAMP biosynthetic process IEA 7805846 GO:0034959 endothelin maturation IDA GO:0035994 response to muscle stretch IEA GO:0042312 regulation of vasodilation IEA 7864876 GO:0042447 hormone catabolic process IDA GO:0042493 response to drug IEA 9915973 GO:0042733 embryonic digit morphogenesis IMP 9915973 GO:0043583 ear development IMP GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway IEA GO:0046686 response to cadmium ion IEA GO:0060037 pharyngeal system development IEA GO:0070372 regulation of ERK1 and ERK2 cascade IEA,7805846 18039931 GO:0004175 endopeptidase activity IDA 8062389 GO:0004222 metalloendopeptidase activity ISS 25416956 GO:0005515 protein binding IPI 7864876 GO:0017046 peptide hormone binding IC 7805846 GO:0042803 protein homodimerization activity IPI GO:0046872 metal ion binding IEA,,CHEMBL CHEMBL8981,P25101,Endothelin receptor ET-A,1.0,ORTHOGONAL,NO,COc1ccc(cc1)C2(O)OC(=O)C(=C2Cc3cc(OC)c(OC)c(OC)c3)c4ccc5OCOc5c4,2,17,"InChI=1S/C28H26O9/c1-31-19-8-6-18(7-9-19)28(30)20(11-16-12-23(32-2)26(34-4)24(13-16)33-3)25(27(29)37-28)17-5-10-21-22(14-17)36-15-35-21/h5-10,12-14,30H,11,15H2,1-4H3",PWIPORDFWDZCJG-UHFFFAOYSA-N,"c(""Endothelin receptor ET-A"", ""Endothelin receptor ET-B"", ""Endothelin receptor, ET-A/ET-B"", ""Unchecked"")",1909,EDNRA,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,IEA GO:0005829 cytosol TAS GO:0005886 plasma membrane TAS 1326535 integral component of plasma membrane GO:0005887 IEA GO:0030315 T-tubule IEA GO:0031965 nuclear membrane IEA GO:0045121 membrane raft,patterning of blood vessels IEA GO:0001569 response to hypoxia IEA GO:0001666 in utero embryonic development IEA GO:0001701 histamine secretion IEA GO:0001821 glomerular filtration IEA GO:0003094 smooth muscle contraction NAS 9284755 GO:0006939 signal transduction TAS 1326535 GO:0007165 G-protein coupled receptor signaling pathway NAS 8611157 GO:0007186 activation of adenylate cyclase activity TAS 8702836 GO:0007190 activation of phospholipase C activity TAS 8702836 GO:0007202 positive regulation of cytosolic calcium ion concentration TAS 1849646 GO:0007204 protein kinase C-activating G-protein coupled receptor signaling pathway IEA GO:0007205 Rho protein signal transduction IEA GO:0007266 heart development IEA GO:0007507 aging IEA GO:0007568 respiratory gaseous exchange ISS GO:0007585 regulation of blood pressure IEA GO:0008217 cell proliferation NAS 9284755 GO:0008283 positive regulation of cell proliferation IEA GO:0008284 neural crest cell development IEA GO:0014032 artery smooth muscle contraction IMP 8982507 GO:0014824 glucose transport ISS GO:0015758 sensory perception of pain IEA GO:0019233 negative regulation of cAMP biosynthetic process IEA GO:0030818 response to lipopolysaccharide IEA GO:0032496 vasoconstriction IMP 8982507 GO:0042310 positive regulation of odontogenesis IEA GO:0042482 negative regulation of apoptotic process IEA GO:0043066 penile erection IEA GO:0043084 response to morphine IEA GO:0043278 fibroblast proliferation IEA GO:0048144 enteric nervous system development IEA GO:0048484 smooth muscle cell proliferation IEA GO:0048659 regulation of epithelial cell proliferation IEA GO:0050678 positive regulation of inflammatory response IEA GO:0050729 positive regulation of release of sequestered calcium ion into cytosol IEA GO:0051281 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA GO:0051482 maternal process involved in parturition IEA GO:0060137 head development IEA GO:0060322 positive regulation of ERK1 and ERK2 cascade IEA GO:0070374 cellular response to mechanical stimulus IEA GO:0071260 endothelin receptor signaling pathway IEA GO:0086100 positive regulation of neutrophil chemotaxis IEA GO:0090023 positive regulation of kidney development IEA GO:0090184,phosphatidylinositol phospholipase C activity TAS 8702836 GO:0004435 endothelin receptor activity NAS 8611157 9284755 GO:0004962 protein binding IPI 23597562 GO:0005515,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) hsa04924 Renin secretion - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human),CHEMBL CHEMBL267458,P25101,Endothelin receptor ET-A,1.0,PRIMARY,NO,CN(C)c1cccc2c(cccc12)S(=O)(=O)Nc3onc(C)c3C,2,25,"InChI=1S/C17H19N3O3S/c1-11-12(2)18-23-17(11)19-24(21,22)16-10-6-7-13-14(16)8-5-9-15(13)20(3)4/h5-10,19H,1-4H3",MJRGSRRZKSJHOE-UHFFFAOYSA-N,"c(""Endothelin receptor ET-A"", ""Endothelin receptor ET-B"", ""Menin/Histone-lysine N-methyltransferase MLL"", ""Endoplasmic reticulum-associated amyloid beta-peptide-binding protein"", ""Lysine-specific demethylase 4D-like"", ""Thyroid stimulating hormone receptor"", ""15-hydroxyprostaglandin dehydrogenase [NAD+]"", ""Unchecked"", ""Histone acetyltransferase GCN5"", ""Vitamin D receptor"", ""Ubiquitin carboxyl-terminal hydrolase 1"")",1909,EDNRA,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,IEA GO:0005829 cytosol TAS GO:0005886 plasma membrane TAS 1326535 integral component of plasma membrane GO:0005887 IEA GO:0030315 T-tubule IEA GO:0031965 nuclear membrane IEA GO:0045121 membrane raft,patterning of blood vessels IEA GO:0001569 response to hypoxia IEA GO:0001666 in utero embryonic development IEA GO:0001701 histamine secretion IEA GO:0001821 glomerular filtration IEA GO:0003094 smooth muscle contraction NAS 9284755 GO:0006939 signal transduction TAS 1326535 GO:0007165 G-protein coupled receptor signaling pathway NAS 8611157 GO:0007186 activation of adenylate cyclase activity TAS 8702836 GO:0007190 activation of phospholipase C activity TAS 8702836 GO:0007202 positive regulation of cytosolic calcium ion concentration TAS 1849646 GO:0007204 protein kinase C-activating G-protein coupled receptor signaling pathway IEA GO:0007205 Rho protein signal transduction IEA GO:0007266 heart development IEA GO:0007507 aging IEA GO:0007568 respiratory gaseous exchange ISS GO:0007585 regulation of blood pressure IEA GO:0008217 cell proliferation NAS 9284755 GO:0008283 positive regulation of cell proliferation IEA GO:0008284 neural crest cell development IEA GO:0014032 artery smooth muscle contraction IMP 8982507 GO:0014824 glucose transport ISS GO:0015758 sensory perception of pain IEA GO:0019233 negative regulation of cAMP biosynthetic process IEA GO:0030818 response to lipopolysaccharide IEA GO:0032496 vasoconstriction IMP 8982507 GO:0042310 positive regulation of odontogenesis IEA GO:0042482 negative regulation of apoptotic process IEA GO:0043066 penile erection IEA GO:0043084 response to morphine IEA GO:0043278 fibroblast proliferation IEA GO:0048144 enteric nervous system development IEA GO:0048484 smooth muscle cell proliferation IEA GO:0048659 regulation of epithelial cell proliferation IEA GO:0050678 positive regulation of inflammatory response IEA GO:0050729 positive regulation of release of sequestered calcium ion into cytosol IEA GO:0051281 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA GO:0051482 maternal process involved in parturition IEA GO:0060137 head development IEA GO:0060322 positive regulation of ERK1 and ERK2 cascade IEA GO:0070374 cellular response to mechanical stimulus IEA GO:0071260 endothelin receptor signaling pathway IEA GO:0086100 positive regulation of neutrophil chemotaxis IEA GO:0090023 positive regulation of kidney development IEA GO:0090184,phosphatidylinositol phospholipase C activity TAS 8702836 GO:0004435 endothelin receptor activity NAS 8611157 9284755 GO:0004962 protein binding IPI 23597562 GO:0005515,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) hsa04924 Renin secretion - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human),CHEMBL CHEMBL413825,P24530,Endothelin receptor ET-B,1.0,PRIMARY,NO,C[C@@H](O)[C@H]1NC(=O)CNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](CC(=O)N)NC(=O)CNC(=O)[C@H](CC(=O)N[C@@H](Cc5c[nH]c6ccccc56)C(=O)N[C@@H](Cc7ccccc7)C(=O)N[C@@H](Cc8ccccc8)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc9ccc(O)cc9)C(=O)N[C@@H](Cc%10ccc(O)cc%10)C(=O)N[C@@H](Cc%11c[nH]c%12ccccc%11%12)C(=O)O)NC(=O)[C@H]%13CCCN%13C(=O)[C@H](C)NC1=O,2,4,"InChI=1S/C103H115N23O23/c1-54-102(147)126-35-15-26-83(126)100(145)123-81(91(136)110-51-87(133)115-79(44-84(104)130)98(143)120-77(41-61-48-108-70-24-13-10-21-67(61)70)97(142)121-78(43-63-50-106-53-112-63)90(135)111-52-88(134)125-89(55(2)127)101(146)113-54)46-86(132)114-76(40-60-47-107-69-23-12-9-20-66(60)69)96(141)118-72(36-56-16-5-3-6-17-56)92(137)116-73(37-57-18-7-4-8-19-57)94(139)122-80(45-85(105)131)99(144)119-74(38-58-27-31-64(128)32-28-58)93(138)117-75(39-59-29-33-65(129)34-30-59)95(140)124-82(103(148)149)42-62-49-109-71-25-14-11-22-68(62)71/h3-14,16-25,27-34,47-50,53-55,72-83,89,107-109,127-129H,15,26,35-46,51-52H2,1-2H3,(H2,104,130)(H2,105,131)(H,106,112)(H,110,136)(H,111,135)(H,113,146)(H,114,132)(H,115,133)(H,116,137)(H,117,138)(H,118,141)(H,119,144)(H,120,143)(H,121,142)(H,122,139)(H,123,145)(H,124,140)(H,125,134)(H,148,149)/t54-,55+,72-,73-,74-,75-,76-,77-,78+,79+,80-,81-,82-,83+,89+/m0/s1",VWFLFTLWXQPVNV-SYUZYMOHSA-N,"c(""Endothelin receptor ET-A"", ""Endothelin receptor ET-B"")",1910,EDNRB,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,IEA GO:0005829 cytosol TAS GO:0005886 plasma membrane 8810293 TAS GO:0005887 integral component of plasma membrane IEA GO:0031965 nuclear membrane IEA GO:0045121 membrane raft,GO:0000122 negative regulation of transcription from RNA polymerase II promoter 19767294 IMP GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS GO:0001755 neural crest cell migration IEA GO:0001934 positive regulation of protein phosphorylation IEA GO:0006885 regulation of pH IEA GO:0007166 cell surface receptor signaling pathway 8810293 TAS GO:0007194 negative regulation of adenylate cyclase activity 9556633 TAS GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA GO:0007204 positive regulation of cytosolic calcium ion concentration IEA GO:0007399 nervous system development 8001158 TAS GO:0007422 peripheral nervous system development IEA GO:0007497 posterior midgut development IEA GO:0007568 aging IEA GO:0008217 regulation of blood pressure IEA GO:0008284 positive regulation of cell proliferation IEA GO:0014043 negative regulation of neuron maturation ISS GO:0014070 response to organic cyclic compound IEA GO:0014826 vein smooth muscle contraction 8982507 IMP GO:0019233 sensory perception of pain IEA GO:0019934 cGMP-mediated signaling IEA GO:0030318 melanocyte differentiation IEA GO:0031620 regulation of fever generation IEA GO:0032269 negative regulation of cellular protein metabolic process 19767294 IMP GO:0035645 enteric smooth muscle cell differentiation ISS GO:0035810 positive regulation of urine volume IEA GO:0035815 positive regulation of renal sodium excretion IEA GO:0042045 epithelial fluid transport IEA GO:0042310 vasoconstriction 8982507 IMP GO:0042311 vasodilation IEA GO:0043066 negative regulation of apoptotic process IEA GO:0048246 macrophage chemotaxis 12207323 IMP GO:0048265 response to pain IEA GO:0048484 enteric nervous system development ISS GO:0050678 regulation of epithelial cell proliferation IEA GO:0051930 regulation of sensory perception of pain IEA GO:0060406 positive regulation of penile erection IEA GO:0071222 cellular response to lipopolysaccharide IEA GO:0086100 endothelin receptor signaling pathway 1713452 IDA GO:0086100 endothelin receptor signaling pathway 19767294 IMP,GO:0004962 endothelin receptor activity 1713452 IDA GO:0004962 endothelin receptor activity 19767294 IMP GO:0005515 protein binding 23597562 IPI GO:0017046 peptide hormone binding 1713452 IPI GO:0031702 type 1 angiotensin receptor binding IEA,Calcium signaling pathway - Homo sapiens (human) hsa04020 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Melanogenesis - Homo sapiens (human) hsa04916 Pathways in cancer - Homo sapiens (human) hsa05200,CHEMBL CHEMBL2392692,P34913,Epoxide hydratase,1.0,PRIMARY,NO,CNc1nc(C)nc(n1)N2CCC(CC2)C(=O)NCc3ccc(Br)cc3OC(F)(F)F,42,53,"InChI=1S/C19H22BrF3N6O2/c1-11-26-17(24-2)28-18(27-11)29-7-5-12(6-8-29)16(30)25-10-13-3-4-14(20)9-15(13)31-19(21,22)23/h3-4,9,12H,5-8,10H2,1-2H3,(H,25,30)(H,24,26,27,28)",PVTFEAGMCGMRRS-UHFFFAOYSA-N,"c(""Dopamine transporter"", ""Norepinephrine transporter"", ""Unchecked"", ""Vasopressin V1a receptor"", ""Vasoactive intestinal polypeptide receptor 1"", ""Serotonin 7 (5-HT7) receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Serotonin 5a (5-HT5a) receptor"", ""Serotonin 3a (5-HT3a) receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Mu opioid receptor"", ""Kappa opioid receptor"", ""Neurotensin receptor 1"", ""Neuropeptide Y receptor type 2"", ""Neuropeptide Y receptor type 1"", ""Neurokinin 3 receptor"", ""Neurokinin 2 receptor"", ""Muscarinic acetylcholine receptor M4"", ""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M1"", ""Melatonin receptor 1A"", ""Melanocortin receptor 4"", ""Histamine H2 receptor"", ""Histamine H1 receptor"", ""Interleukin-8 receptor B"", ""Galanin receptor 2"", ""Endothelin receptor ET-A"", ""Dopamine D2 receptor"", ""Dopamine D1 receptor"", ""Cholecystokinin A receptor"", ""Type-1 angiotensin II receptor"", ""Beta-1 adrenergic receptor"", ""Beta-2 adrenergic receptor"", ""Adenosine A3 receptor"", ""Adenosine A2a receptor"", ""Adenosine A1 receptor"", ""Sodium channel protein type V alpha subunit"", ""Voltage-gated L-type calcium channel alpha-1C subunit"", ""Epoxide hydrolase 1"", ""Epoxide hydratase"")",2053,HYES,R-HSA-1430728 Metabolism R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142753 Arachidonic acid metabolism R-HSA-556833 Metabolism of lipids and lipoproteins,cytoplasm GO:0005737 IDA peroxisome GO:0005777 16314446 18513744 IDA cytosol GO:0005829 8342951 16314446 18513744 IDA cytosol GO:0005829 10862610 NAS cytosol GO:0005829 TAS extracellular exosome GO:0070062 19056867 23376485 23533145 IDA,xenobiotic metabolic process GO:0006805 NAS 10862610 cellular calcium ion homeostasis GO:0006874 NAS 10862610 inflammatory response GO:0006954 NAS 10862610 regulation of blood pressure GO:0008217 NAS 10862610 response to toxic substance GO:0009636 NAS 10862610 positive regulation of gene expression GO:0010628 IDA 18974052 dephosphorylation GO:0016311 IDA 12574508 drug metabolic process GO:0017144 NAS 10862610 epoxygenase P450 pathway GO:0019373 TAS cholesterol homeostasis GO:0042632 IDA 18974052 positive regulation of vasodilation GO:0045909 NAS 10862610 stilbene catabolic process GO:0046272 IDA 8342951 phospholipid dephosphorylation GO:0046839 IDA 12574510 reactive oxygen species metabolic process GO:0072593 NAS 10862610 regulation of cholesterol metabolic process GO:0090181 IMP 18974052,magnesium ion binding GO:0000287 IDA 12574510 epoxide hydrolase activity GO:0004301 IDA 8342951 10862610 epoxide hydrolase activity GO:0004301 TAS receptor binding GO:0005102 IPI 20178365 toxic substance binding GO:0015643 IDA 15096040 phosphatase activity GO:0016791 IDA 12574508 15196990 10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity GO:0033885 IEA lipid phosphatase activity GO:0042577 IDA 12574510 protein homodimerization activity GO:0042803 IDA 15096040 18513744 protein homodimerization activity GO:0042803 NAS 10862610,Arachidonic acid metabolism - Homo sapiens (human) hsa00590 Peroxisome - Homo sapiens (human) hsa04146,CHEMBL CHEMBL2041378,P14061,Estradiol 17-beta-dehydrogenase 1,1.0,ORTHOGONAL,NO,CC(=O)Nc1ccc(cc1)S(=O)(=O)Nc2cccc(c2)c3c(O)ccc4cc(ccc34)c5cccc(O)c5,4,9,"InChI=1S/C30H24N2O5S/c1-19(33)31-24-10-12-27(13-11-24)38(36,37)32-25-6-2-5-23(17-25)30-28-14-8-21(16-22(28)9-15-29(30)35)20-4-3-7-26(34)18-20/h2-18,32,34-35H,1H3,(H,31,33)",AJKBVOKBNKWIQX-UHFFFAOYSA-N,"c(""Estradiol 17-beta-dehydrogenase 1"", ""Estrogen receptor beta"", ""Estrogen receptor alpha"", ""Unchecked"", ""Estradiol 17-beta-dehydrogenase 2"")",3292,DHB1,Metabolism R-HSA-1430728 Signal Transduction R-HSA-162582 Estrogen biosynthesis R-HSA-193144 Metabolism of steroid hormones and vitamin D R-HSA-196071 Steroid hormones R-HSA-209943 Visual phototransduction R-HSA-2187338 The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 Metabolism of lipids and lipoproteins R-HSA-556833,nucleoplasm GO:0005654 IDA cytoplasm GO:0005737 IDA cytosol GO:0005829 TAS nuclear membrane GO:0031965 IDA,TAS 8547176 steroid biosynthetic process GO:0006694 IEA GO:0006703 estrogen biosynthetic process TAS GO:0006703 estrogen biosynthetic process TAS 2584224 estrogen metabolic process GO:0008210 IEA GO:0055114 oxidation-reduction process IEA GO:0060348 bone development IEA GO:0061370 testosterone biosynthetic process IEA GO:0071248 cellular response to metal ion,TAS 8547176 catalytic activity GO:0003824 TAS GO:0004303 estradiol 17-beta-dehydrogenase activity IEA GO:0047035 testosterone dehydrogenase (NAD+) activity,hsa00140 Steroid hormone biosynthesis - Homo sapiens (human) hsa04913 Ovarian steroidogenesis - Homo sapiens (human),CHEMBL CHEMBL1650645,P14061,Estradiol 17-beta-dehydrogenase 1,1.0,PRIMARY,NO,Oc1cccc(c1)c2ccc3c(c(O)ccc3c2)c4cccnc4,4,10,"InChI=1S/C21H15NO2/c23-18-5-1-3-14(12-18)15-6-8-19-16(11-15)7-9-20(24)21(19)17-4-2-10-22-13-17/h1-13,23-24H",AXMKFPDKHLZNID-UHFFFAOYSA-N,"c(""Estrogen receptor beta"", ""Estrogen receptor alpha"", ""Estradiol 17-beta-dehydrogenase 1"", ""Unchecked"", ""Estradiol 17-beta-dehydrogenase 2"")",3292,DHB1,Metabolism R-HSA-1430728 Signal Transduction R-HSA-162582 Estrogen biosynthesis R-HSA-193144 Metabolism of steroid hormones and vitamin D R-HSA-196071 Steroid hormones R-HSA-209943 Visual phototransduction R-HSA-2187338 The canonical retinoid cycle in rods (twilight vision) R-HSA-2453902 Metabolism of lipids and lipoproteins R-HSA-556833,nucleoplasm GO:0005654 IDA cytoplasm GO:0005737 IDA cytosol GO:0005829 TAS nuclear membrane GO:0031965 IDA,TAS 8547176 steroid biosynthetic process GO:0006694 IEA GO:0006703 estrogen biosynthetic process TAS GO:0006703 estrogen biosynthetic process TAS 2584224 estrogen metabolic process GO:0008210 IEA GO:0055114 oxidation-reduction process IEA GO:0060348 bone development IEA GO:0061370 testosterone biosynthetic process IEA GO:0071248 cellular response to metal ion,TAS 8547176 catalytic activity GO:0003824 TAS GO:0004303 estradiol 17-beta-dehydrogenase activity IEA GO:0047035 testosterone dehydrogenase (NAD+) activity,hsa00140 Steroid hormone biosynthesis - Homo sapiens (human) hsa04913 Ovarian steroidogenesis - Homo sapiens (human),CHEMBL CHEMBL2324690,P37059,Estradiol 17-beta-dehydrogenase 2,1.0,PRIMARY,NO,COc1cccc(c1)N(C)C(=O)c2ccc(s2)c3cccc(C)c3,7,20,"InChI=1S/C20H19NO2S/c1-14-6-4-7-15(12-14)18-10-11-19(24-18)20(22)21(2)16-8-5-9-17(13-16)23-3/h4-13H,1-3H3",BABRITZRSIMSNK-UHFFFAOYSA-N,"c(""Unchecked"", ""11-beta-hydroxysteroid dehydrogenase 2"", ""11-beta-hydroxysteroid dehydrogenase 1"", ""Aldo-keto-reductase family 1 member C3"", ""Estradiol 17-beta-dehydrogenase 2"", ""Estradiol 17-beta-dehydrogenase 1"", ""Estrogen receptor beta"", ""Estrogen receptor alpha"")",3294,DHB2,,8099587 GO:0005789 endoplasmic reticulum membrane TAS GO:0016021 integral component of membrane IEA,IEA GO:0001701 in utero embryonic development IEA GO:0001890 placenta development IEA GO:0006694 steroid biosynthetic process 17538076 IDA GO:0032526 response to retinoic acid IEA GO:0055114 oxidation-reduction process,"8099587 17538076 IDA GO:0004303 estradiol 17-beta-dehydrogenase activity 17538076 TAS GO:0047006 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity 8099587 IDA GO:0047035 testosterone dehydrogenase (NAD+) activity",Steroid hormone biosynthesis - Homo sapiens (human) hsa00140 Ovarian steroidogenesis - Homo sapiens (human) hsa04913,CHEMBL CHEMBL282575,P03372,Estrogen receptor alpha,1.0,PRIMARY,NO,C[C@]12CC[C@H]3[C@@H](CCc4cc(OC(=O)c5ccccc5)ccc34)[C@@H]1CC[C@@H]2O,10,40,"InChI=1S/C25H28O3/c1-25-14-13-20-19-10-8-18(28-24(27)16-5-3-2-4-6-16)15-17(19)7-9-21(20)22(25)11-12-23(25)26/h2-6,8,10,15,20-23,26H,7,9,11-14H2,1H3/t20-,21-,22+,23+,25+/m1/s1",UYIFTLBWAOGQBI-BZDYCCQFSA-N,"c(""Unchecked"", ""Testis-specific androgen-binding protein"", ""Prelamin-A/C"", ""Histone-lysine N-methyltransferase MLL"", ""Survival motor neuron protein"", ""Huntingtin"", ""Serine-protein kinase ATM"", ""Nuclear factor erythroid 2-related factor 2"", ""ATPase family AAA domain-containing protein 5"", ""Chromobox protein homolog 1"", ""Ubiquitin carboxyl-terminal hydrolase 1"", ""Adenosine A3 receptor"", ""Alpha-2c adrenergic receptor"", ""Norepinephrine transporter"", ""Estrogen receptor alpha"", ""Glucocorticoid receptor"", ""Tyrosine-protein kinase FYN"", ""Serotonin 2b (5-HT2b) receptor"", ""Serotonin transporter"", ""78 kDa glucose-regulated protein"", ""Geminin"", ""Glucagon-like peptide 1 receptor"", ""Androgen Receptor"", ""Muscleblind-like protein 1"")",2099,ESR1,R-HSA-1236394 Signaling by ERBB4 R-HSA-1251985 Nuclear signaling by ERBB4 R-HSA-162582 Signal Transduction R-HSA-212436 Generic Transcription Pathway R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-74160 Gene Expression,nuclear chromatin IDA 15831516 20388878 GO:0000790 nucleus IDA 15569929 17505058 20074560 20080953 GO:0005634 nucleoplasm TAS GO:0005654 cytoplasm IDA 17505058 GO:0005737 mitochondrion IEA GO:0005739 Golgi apparatus IEA GO:0005794 plasma membrane IDA 15569929 GO:0005886 membrane NAS 11960618 GO:0016020 integral component of membrane IEA GO:0016021 T-tubule IEA GO:0030315 transcriptionally active chromatin IDA 17505058 GO:0035327 terminal bouton IEA GO:0043195 perikaryon IEA GO:0043204 protein complex IEA GO:0043234 perinuclear region of cytoplasm IEA GO:0048471,"negative regulation of transcription from RNA polymerase II promoter GO:0000122 20388878 IMP antral ovarian follicle growth GO:0001547 IEA osteoblast development GO:0002076 IEA chromatin remodeling GO:0006338 12351687 NAS transcription, DNA-templated GO:0006351 2040605 TAS regulation of transcription, DNA-templated GO:0006355 3753802 NAS transcription from RNA polymerase II promoter GO:0006366 15831516 IDA transcription initiation from RNA polymerase II promoter GO:0006367 TAS signal transduction GO:0007165 10749889 10970861 TAS phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 ISS positive regulation of cytosolic calcium ion concentration GO:0007204 ISS androgen metabolic process GO:0008209 IEA negative regulation of gene expression GO:0010629 21695196 IDA positive regulation of phospholipase C activity GO:0010863 ISS intracellular steroid hormone receptor signaling pathway GO:0030518 ISS intracellular estrogen receptor signaling pathway GO:0030520 3753802 NAS response to estradiol GO:0032355 15304487 IDA negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 7651415 16043358 IDA negative regulation of sequence-specific DNA binding transcription factor activity GO:0043433 10816575 IDA regulation of neuron apoptotic process GO:0043523 IEA response to estrogen GO:0043627 11581164 IDA positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 IEA positive regulation of transcription, DNA-templated GO:0045893 20074560 IDA positive regulation of transcription from RNA polymerase II promoter GO:0045944 11544182 12047722 15345745 15831516 IDA negative regulation of glucose import GO:0046325 IEA decidualization GO:0046697 IEA positive regulation of fibroblast proliferation GO:0048146 IEA negative regulation of smooth muscle cell proliferation GO:0048662 IEA positive regulation of epithelial cell proliferation GO:0050679 IEA positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9328340 10681512 IDA Sertoli cell development GO:0060009 IEA Sertoli cell proliferation GO:0060011 IEA uterus development GO:0060065 IEA vagina development GO:0060068 IEA prostate epithelial cord elongation GO:0060523 IEA prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis GO:0060527 IEA regulation of branching involved in prostate gland morphogenesis GO:0060687 IEA mammary gland branching involved in pregnancy GO:0060745 IEA mammary gland alveolus development GO:0060749 IEA epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 IEA positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA protein localization to chromatin GO:0071168 20388878 IMP cellular response to estradiol stimulus GO:0071392 15831516 IDA cellular response to estradiol stimulus GO:0071392 ISS negative regulation of triglyceride metabolic process GO:0090209 IEA negative regulation of neuron death GO:1901215 IEA negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 20388878 IMP baculum development GO:1990375 IEA","RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 12047722 IDA core promoter sequence-specific DNA binding GO:0001046 15345745 IDA transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 12047722 IDA transcription coactivator binding GO:0001223 IEA chromatin binding GO:0003682 17505058 IDA transcription factor activity, sequence-specific DNA binding GO:0003700 12552091 NAS steroid hormone receptor activity GO:0003707 10749889 TAS steroid binding GO:0005496 ISS protein binding GO:0005515 7641693 7651415 9328340 9627117 9628876 9653119 10359819 10816575 10866662 11178989 11265755 11279242 11353774 11477071 11581164 11682626 11875103 12039952 12093804 12660241 12917342 14701856 14764652 14963108 15199063 15569929 15674350 15891768 16603732 16606617 16709599 16957778 17006958 17043237 17085477 17284441 17347654 17363140 17545996 17627277 17914104 17932106 17975005 18025262 19039327 19350539 19423554 20074560 20080953 20413580 21104395 21182203 21182205 21217774 21841772 22093364 23065768 23178685 23576398 25219498 25604459 25675114 IPI beta-catenin binding GO:0008013 15304487 IPI transcription factor binding GO:0008134 17505058 IPI zinc ion binding GO:0008270 IEA enzyme binding GO:0019899 12039952 22853951 IPI nitric-oxide synthase regulator activity GO:0030235 12389206 NAS estrogen receptor activity GO:0030284 3753802 NAS type 1 metabotropic glutamate receptor binding GO:0031798 IEA protein complex binding GO:0032403 IEA estrogen response element binding GO:0034056 15345745 15831516 17975005 IDA phosphatidylinositol 3-kinase regulatory subunit binding GO:0036312 IEA RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 15831516 IDA RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding GO:0038052 18722177 IGI hormone binding GO:0042562 IEA identical protein binding GO:0042802 11265755 11682626 21182205 23065768 IPI ATPase binding GO:0051117 12058073 IDA",hsa04915 Estrogen signaling pathway - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human),CHEMBL CHEMBL1782957,Q92731,Estrogen receptor beta,1.0,PRIMARY,YES,O\N=C\c1c(O)ccc(c1Cl)c2ccc(O)cc2,6,14,"InChI=1S/C13H10ClNO3/c14-13-10(8-1-3-9(16)4-2-8)5-6-12(17)11(13)7-15-18/h1-7,16-18H/b15-7+",OGRZJPRETQPCLH-VIZOYTHASA-N,"c(""Estrogen receptor alpha"", ""Estrogen receptor beta"", ""Unchecked"", ""Carbonic anhydrase XII"", ""Carbonic anhydrase IX"", ""Carbonic anhydrase II"", ""Carbonic anhydrase I"")",2100,ESR2,Generic Transcription Pathway R-HSA-212436 Nuclear Receptor transcription pathway R-HSA-383280 Gene Expression R-HSA-74160,GO:0005576 extracellular region IEA GO:0005634 nucleus 19126643 20074560 IDA GO:0005634 nucleus 11181953 TAS GO:0005654 nucleoplasm TAS GO:0005739 mitochondrion 15024130 IDA GO:0005886 plasma membrane IEA GO:0005929 cilium IEA GO:0032993 protein-DNA complex IEA GO:0043005 neuron projection IEA GO:0043204 perikaryon IEA GO:0048471 perinuclear region of cytoplasm IEA,"negative regulation of transcription from RNA polymerase II promoter 15345745 GO:0000122 IDA ovarian follicle development GO:0001541 IEA behavioral fear response GO:0001662 IEA regulation of transcription, DNA-templated 11181953 GO:0006355 TAS transcription initiation from RNA polymerase II promoter GO:0006367 TAS signal transduction 8769313 10749889 GO:0007165 TAS cell-cell signaling 8769313 GO:0007267 TAS learning or memory GO:0007611 IEA response to water deprivation GO:0009414 IEA response to activity GO:0014823 IEA response to insecticide GO:0017085 IEA cerebellum development GO:0021549 IEA amygdala development GO:0021764 IEA hypothalamus development GO:0021854 IEA negative regulation of cell growth 11181953 GO:0030308 NAS intracellular estrogen receptor signaling pathway 11181953 GO:0030520 TAS prostate gland development GO:0030850 IEA response to nutrient levels GO:0031667 IEA response to testosterone GO:0033574 IEA response to genistein GO:0033595 IEA cellular response to drug GO:0035690 IEA positive regulation of apoptotic process GO:0043065 IEA regulation of neuron apoptotic process GO:0043523 IEA response to human chorionic gonadotropin GO:0044752 IEA estrous cycle GO:0044849 IEA response to ethanol GO:0045471 IEA positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 IEA positive regulation of transcription, DNA-templated 20074560 GO:0045893 IDA positive regulation of vasodilation GO:0045909 IEA positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA negative regulation of smooth muscle cell proliferation GO:0048662 IEA negative regulation of epithelial cell proliferation GO:0050680 IEA positive regulation of sequence-specific DNA binding transcription factor activity 10681512 GO:0051091 IDA Sertoli cell development GO:0060009 IEA Sertoli cell proliferation GO:0060011 IEA positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA cellular response to magnetism GO:0071259 IEA cellular response to estradiol stimulus GO:0071392 IEA response to dexamethasone GO:0071548 IEA extracellular negative regulation of signal transduction GO:1900116 IEA negative regulation of neuron death GO:1901215 IEA response to salt GO:1902074 IEA response to bisphenol A GO:1903925 IEA negative regulation of feeding behavior GO:2000252 IEA negative regulation of reactive oxygen species metabolic process GO:2000378 IEA","core promoter sequence-specific DNA binding 15345745 GO:0001046 IDA DNA binding 9636657 GO:0003677 TAS transcription factor activity, sequence-specific DNA binding 8769313 GO:0003700 TAS steroid hormone receptor activity 10749889 GO:0003707 TAS transcription coactivator activity 8769313 GO:0003713 TAS RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding 9671811 GO:0004879 NAS steroid binding GO:0005496 ISS steroid binding 11181953 GO:0005496 TAS protein binding 11279242 14764652 15199063 19126643 20074560 25416956 GO:0005515 IPI drug binding GO:0008144 IEA zinc ion binding GO:0008270 IEA enzyme binding 12039952 GO:0019899 IPI estrogen receptor activity 11181953 GO:0030284 TAS estrogen response element binding 15345745 19126643 GO:0034056 IDA RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding 19126643 GO:0038052 IDA peroxisome proliferator activated receptor binding GO:0042975 IEA receptor antagonist activity 9671811 GO:0048019 NAS estradiol binding GO:1903924 IEA steroid hormone binding GO:1990239 IEA",hsa04915 Estrogen signaling pathway - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human),CHEMBL CHEMBL555196,P60842,Eukaryotic initiation factor 4A-I,1.0,PRIMARY,NO,CO[C@@H]1OC[C@@H](O[C@H]1Oc2cc(OC)c3c(O[C@]4([C@@H]([C@H]([C@@H](O)[C@@]34O)C(=O)OC)c5ccccc5)c6ccc(OC)cc6)c2)[C@H](O)CO,2,15,"InChI=1S/C34H38O13/c1-40-20-12-10-19(11-13-20)34-27(18-8-6-5-7-9-18)26(30(38)42-3)29(37)33(34,39)28-23(41-2)14-21(15-24(28)47-34)45-32-31(43-4)44-17-25(46-32)22(36)16-35/h5-15,22,25-27,29,31-32,35-37,39H,16-17H2,1-4H3/t22-,25-,26-,27-,29-,31-,32-,33+,34+/m1/s1",GVKXFVCXBFGBCD-QKDMMWSPSA-N,"c(""MCF7"", ""LNCaP"", ""Lu1"", ""Unchecked"", ""Nuclear factor NF-kappa-B p65 subunit"", ""HT-29"", ""MDA-MB-435"", ""Eukaryotic initiation factor 4A-I"", ""MDA-MB-231"")",1973,IF4A1,"R-HSA-1169408 ISG15 antiviral mechanism R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression R-HSA-157279 3, -UTR-mediated translational regulation R-HSA-168256 Immune System R-HSA-392499 Metabolism of proteins R-HSA-429914 Deadenylation-dependent mRNA decay R-HSA-429947 Deadenylation of mRNA R-HSA-72613 Eukaryotic Translation Initiation R-HSA-72649 Translation initiation complex formation R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S R-HSA-72702 Ribosomal scanning and start codon recognition R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit R-HSA-72737 Cap-dependent Translation Initiation R-HSA-72766 Translation R-HSA-74160 Gene Expression R-HSA-913531 Interferon Signaling",nucleus GO:0005634 NOT IDA 12426392 cytoplasm GO:0005737 IDA 12426392 cytosol GO:0005829 TAS membrane GO:0016020 IDA 19946888 eukaryotic translation initiation factor 4F complex GO:0016281 TAS 9168945 extracellular exosome GO:0070062 IDA 20458337 23376485,GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS GO:0006413 translational initiation IBA GO:0006413 translational initiation TAS GO:0006446 regulation of translational initiation IEA GO:0010468 regulation of gene expression IBA GO:0010501 RNA secondary structure unwinding IBA GO:0016032 viral process IEA GO:0031100 organ regeneration IEA,"3215517 GO:0000339 RNA cap binding TAS 21266579 GO:0003725 double-stranded RNA binding IDA 3215517 GO:0003729 mRNA binding TAS GO:0003743 translation initiation factor activity IEA GO:0004004 ATP-dependent RNA helicase activity IBA 3215517 GO:0004386 helicase activity TAS 9548260 16166382 16932749 17284590 19203580 23023399 24413684 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA 3215517 10880459 GO:0008135 translation factor activity, RNA binding TAS 22658674 22681889 GO:0044822 poly(A) RNA binding IDA",RNA transport - Homo sapiens (human) hsa03013,CHEMBL CHEMBL2441340,Q9NZJ5,Eukaryotic translation initiation factor 2-alpha kinase 3,1.0,ORTHOGONAL,NO,Cc1cccc(CC(=O)N2CCc3c(F)c(ccc23)c4cn(C)c5ncnc(N)c45)n1,4,8,"InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27)",PRWSIEBRGXYXAJ-UHFFFAOYSA-N,"c(""Unchecked"", ""Eukaryotic translation initiation factor 2-alpha kinase 4"", ""Interferon-induced, double-stranded RNA-activated protein kinase"", ""Eukaryotic translation initiation factor 2-alpha kinase 1"", ""Eukaryotic translation initiation factor 2-alpha kinase 3"")",9451,E2AK3,PERK regulates gene expression R-HSA-381042 Unfolded Protein Response (UPR) R-HSA-381119 Metabolism of proteins R-HSA-392499,ISS GO:0005737 cytoplasm IC 11907036 endoplasmic reticulum GO:0005783 ISS GO:0005783 endoplasmic reticulum TAS 12086964 endoplasmic reticulum GO:0005783 ISS GO:0005789 endoplasmic reticulum membrane NAS 11907036 endoplasmic reticulum membrane GO:0005789 TAS GO:0005789 endoplasmic reticulum membrane IDA 19946888 membrane GO:0016020 NAS 22013210 22934019 integral component of endoplasmic reticulum membrane GO:0030176 IEA GO:0048471 perinuclear region of cytoplasm,skeletal system development ISS GO:0001501 ossification IMP 12086964 GO:0001503 angiogenesis IMP 22915762 GO:0001525 chondrocyte development ISS GO:0002063 protein phosphorylation ISS GO:0006468 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS GO:0006919 ER overload response IDA 10677345 11907036 GO:0006983 endoplasmic reticulum organization ISS GO:0007029 positive regulation of vascular endothelial growth factor production IMP 22915762 GO:0010575 positive regulation of gene expression IMP 22915762 GO:0010628 regulation of translational initiation by eIF2 alpha phosphorylation ISS GO:0010998 negative regulation of translation TAS 12086964 GO:0017148 peptidyl-serine phosphorylation ISS GO:0018105 calcium-mediated signaling ISS GO:0019722 insulin secretion ISS GO:0030073 bone mineralization ISS GO:0030282 endoplasmic reticulum unfolded protein response IDA 10677345 11907036 22169477 GO:0030968 endoplasmic reticulum unfolded protein response TAS 19816510 GO:0030968 endocrine pancreas development IMP 12086964 GO:0031018 negative regulation of myelination ISS GO:0031642 negative regulation of translational initiation in response to stress TAS 10677345 12086964 19816510 GO:0032057 cellular response to amino acid starvation IMP 25329545 GO:0034198 response to endoplasmic reticulum stress IMP 19061639 GO:0034976 eiF2alpha phosphorylation in response to endoplasmic reticulum stress IMP 25329545 GO:0036492 eiF2alpha phosphorylation in response to endoplasmic reticulum stress TAS 22934019 GO:0036492 PERK-mediated unfolded protein response TAS 22934019 GO:0036499 cellular response to glucose starvation IMP 22915762 GO:0042149 positive regulation of transcription from RNA polymerase I promoter IMP 22915762 GO:0045943 protein autophosphorylation IDA 10026192 11907036 GO:0046777 protein autophosphorylation IMP 12086964 GO:0046777 insulin-like growth factor receptor signaling pathway ISS GO:0048009 protein homooligomerization IMP 11907036 GO:0051260 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation ISS GO:0060734 cellular response to cold IMP 25329545 GO:0070417 positive regulation of protein localization to nucleus ISS GO:1900182 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP 23000344 GO:1902235 response to manganese-induced endoplasmic reticulum stress IEA GO:1990737,protein kinase activity TAS 10026192 GO:0004672 protein serine/threonine kinase activity ISS GO:0004674 protein serine/threonine kinase activity TAS GO:0004674 eukaryotic translation initiation factor 2alpha kinase activity IDA 10026192 10677345 11907036 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity IMP 12086964 25329545 GO:0004694 protein binding IPI 11907036 25393282 26268696 GO:0005515 ATP binding IEA GO:0005524 enzyme binding IPI 23103912 GO:0019899 protein phosphatase binding IPI 22169477 GO:0019903 identical protein binding IPI 11907036 GO:0042802 protein homodimerization activity TAS 22934019 GO:0042803 Hsp90 protein binding IEA GO:0051879,"hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) hsa04932 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa05010 Alzheimer,s disease - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human) hsa05162 Measles - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05168 Herpes simplex infection - Homo sapiens (human) hsa05169 Epstein-Barr virus infection - Homo sapiens (human)",CHEMBL CHEMBL3407862,Q9NZJ5,Eukaryotic translation initiation factor 2-alpha kinase 3,1.0,PRIMARY,NO,CN1N(C(=O)C(=C1c2ccccc2)C(=O)c3ccc(C)c(c3N)c4ccc5nc(C)ccc5c4)c6ccccc6,3,9,"InChI=1S/C34H28N4O2/c1-21-14-18-27(31(35)29(21)25-17-19-28-24(20-25)16-15-22(2)36-28)33(39)30-32(23-10-6-4-7-11-23)37(3)38(34(30)40)26-12-8-5-9-13-26/h4-20H,35H2,1-3H3",YPPSMYLMSKHYAY-UHFFFAOYSA-N,"c(""Eukaryotic translation initiation factor 2-alpha kinase 3"", ""Eukaryotic translation initiation factor 2-alpha kinase 4"", ""Serine/threonine-protein kinase B-raf"", ""Unchecked"")",9451,E2AK3,PERK regulates gene expression R-HSA-381042 Unfolded Protein Response (UPR) R-HSA-381119 Metabolism of proteins R-HSA-392499,ISS GO:0005737 cytoplasm IC 11907036 endoplasmic reticulum GO:0005783 ISS GO:0005783 endoplasmic reticulum TAS 12086964 endoplasmic reticulum GO:0005783 ISS GO:0005789 endoplasmic reticulum membrane NAS 11907036 endoplasmic reticulum membrane GO:0005789 TAS GO:0005789 endoplasmic reticulum membrane IDA 19946888 membrane GO:0016020 NAS 22013210 22934019 integral component of endoplasmic reticulum membrane GO:0030176 IEA GO:0048471 perinuclear region of cytoplasm,skeletal system development ISS GO:0001501 ossification IMP 12086964 GO:0001503 angiogenesis IMP 22915762 GO:0001525 chondrocyte development ISS GO:0002063 protein phosphorylation ISS GO:0006468 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS GO:0006919 ER overload response IDA 10677345 11907036 GO:0006983 endoplasmic reticulum organization ISS GO:0007029 positive regulation of vascular endothelial growth factor production IMP 22915762 GO:0010575 positive regulation of gene expression IMP 22915762 GO:0010628 regulation of translational initiation by eIF2 alpha phosphorylation ISS GO:0010998 negative regulation of translation TAS 12086964 GO:0017148 peptidyl-serine phosphorylation ISS GO:0018105 calcium-mediated signaling ISS GO:0019722 insulin secretion ISS GO:0030073 bone mineralization ISS GO:0030282 endoplasmic reticulum unfolded protein response IDA 10677345 11907036 22169477 GO:0030968 endoplasmic reticulum unfolded protein response TAS 19816510 GO:0030968 endocrine pancreas development IMP 12086964 GO:0031018 negative regulation of myelination ISS GO:0031642 negative regulation of translational initiation in response to stress TAS 10677345 12086964 19816510 GO:0032057 cellular response to amino acid starvation IMP 25329545 GO:0034198 response to endoplasmic reticulum stress IMP 19061639 GO:0034976 eiF2alpha phosphorylation in response to endoplasmic reticulum stress IMP 25329545 GO:0036492 eiF2alpha phosphorylation in response to endoplasmic reticulum stress TAS 22934019 GO:0036492 PERK-mediated unfolded protein response TAS 22934019 GO:0036499 cellular response to glucose starvation IMP 22915762 GO:0042149 positive regulation of transcription from RNA polymerase I promoter IMP 22915762 GO:0045943 protein autophosphorylation IDA 10026192 11907036 GO:0046777 protein autophosphorylation IMP 12086964 GO:0046777 insulin-like growth factor receptor signaling pathway ISS GO:0048009 protein homooligomerization IMP 11907036 GO:0051260 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation ISS GO:0060734 cellular response to cold IMP 25329545 GO:0070417 positive regulation of protein localization to nucleus ISS GO:1900182 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP 23000344 GO:1902235 response to manganese-induced endoplasmic reticulum stress IEA GO:1990737,protein kinase activity TAS 10026192 GO:0004672 protein serine/threonine kinase activity ISS GO:0004674 protein serine/threonine kinase activity TAS GO:0004674 eukaryotic translation initiation factor 2alpha kinase activity IDA 10026192 10677345 11907036 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity IMP 12086964 25329545 GO:0004694 protein binding IPI 11907036 25393282 26268696 GO:0005515 ATP binding IEA GO:0005524 enzyme binding IPI 23103912 GO:0019899 protein phosphatase binding IPI 22169477 GO:0019903 identical protein binding IPI 11907036 GO:0042802 protein homodimerization activity TAS 22934019 GO:0042803 Hsp90 protein binding IEA GO:0051879,"hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human) hsa04932 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa05010 Alzheimer,s disease - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human) hsa05162 Measles - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05168 Herpes simplex infection - Homo sapiens (human) hsa05169 Epstein-Barr virus infection - Homo sapiens (human)",CHEMBL CHEMBL1628669,P43004,Excitatory amino acid transporter 2,1.0,PRIMARY,NO,N[C@@H](CC(=O)Nc1ccc(Oc2cc(F)c(F)cc2Br)cc1)C(=O)O,3,5,"InChI=1S/C16H13BrF2N2O4/c17-10-5-11(18)12(19)6-14(10)25-9-3-1-8(2-4-9)21-15(22)7-13(20)16(23)24/h1-6,13H,7,20H2,(H,21,22)(H,23,24)/t13-/m0/s1",BNYDDAAZMBUFRG-ZDUSSCGKSA-N,"c(""Excitatory amino acid transporter 3"", ""Excitatory amino acid transporter 1"", ""Excitatory amino acid transporter 2"", ""Unchecked"")",6506,EAA2,Neurotransmitter Release Cycle R-HSA-112310 Neurotransmitter uptake and Metabolism In Glial Cells R-HSA-112313 Transmission across Chemical Synapses R-HSA-112315 Neuronal System R-HSA-112316 Astrocytic Glutamate-Glutamine Uptake And Metabolism R-HSA-210455 Glutamate Neurotransmitter Release Cycle R-HSA-210500 Transmembrane transport of small molecules R-HSA-382551 Amino acid and oligopeptide SLC transporters R-HSA-425374 Transport of inorganic cations/anions and amino acids/oligopeptides R-HSA-425393 SLC-mediated transmembrane transport R-HSA-425407,plasma membrane GO:0005886 TAS cell surface GO:0009986 21399631 IDA membrane GO:0016020 7521911 TAS integral component of membrane GO:0016021 IEA axolemma GO:0030673 IEA,GO:0006811 ion transport TAS GO:0007268 chemical synaptic transmission 7521911 TAS GO:0007632 visual behavior IEA GO:0009611 response to wounding IEA GO:0010259 multicellular organism aging IEA GO:0014047 glutamate secretion TAS GO:0021537 telencephalon development IEA GO:0030534 adult behavior IEA GO:0031668 cellular response to extracellular stimulus IEA GO:0035264 multicellular organism growth IEA GO:0042493 response to drug IEA GO:0043200 response to amino acid IEA GO:0046326 positive regulation of glucose import IEA GO:0051938 L-glutamate import 7521911 IDA GO:0070779 D-aspartate import 7521911 IDA GO:0089711 L-glutamate transmembrane transport IEA,GO:0005313 L-glutamate transmembrane transporter activity 7521911 IDA GO:0005314 high-affinity glutamate transmembrane transporter activity TAS GO:0005515 protein binding 19527721 IPI GO:0015171 amino acid transmembrane transporter activity TAS GO:0015501 glutamate:sodium symporter activity IEA,Glutamatergic synapse - Homo sapiens (human) hsa04724 Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) hsa05014,CHEMBL CHEMBL2088092,P11362,Fibroblast growth factor receptor 1,1.0,PRIMARY,NO,Cc1cc(Nc2nc(NCc3onc(c3)C(C)(C)C)ncc2Br)n[nH]1,4,7,"InChI=1S/C16H20BrN7O/c1-9-5-13(23-22-9)20-14-11(17)8-19-15(21-14)18-7-10-6-12(24-25-10)16(2,3)4/h5-6,8H,7H2,1-4H3,(H3,18,19,20,21,22,23)",XKPXDWQAHHLAML-UHFFFAOYSA-N,"c(""Fibroblast growth factor receptor 1"", ""Vascular endothelial growth factor receptor 2"", ""Insulin-like growth factor I receptor"", ""Insulin receptor"")",2260,FGFR1,"PI3K Cascade R-HSA-109704 IRS-mediated signalling R-HSA-112399 SOS-mediated signalling R-HSA-112412 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 Signaling by FGFR in disease R-HSA-1226099 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 SHC1 events in ERBB2 signaling R-HSA-1250196 PI3K events in ERBB4 signaling R-HSA-1250342 SHC1 events in ERBB4 signaling R-HSA-1250347 PIP3 activates AKT signaling R-HSA-1257604 Developmental Biology R-HSA-1266738 Cytokine Signaling in Immune system R-HSA-1280215 Adaptive Immune System R-HSA-1280218 Klotho-mediated ligand binding R-HSA-1307973 Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Prolonged ERK activation events R-HSA-169893 Frs2-mediated activation R-HSA-170968 ARMS-mediated activation R-HSA-170984 Signaling by EGFR R-HSA-177929 GRB2 events in EGFR signaling R-HSA-179812 GAB1 signalosome R-HSA-180292 SHC1 events in EGFR signaling R-HSA-180336 Signaling by FGFR1 amplification mutants R-HSA-1839120 Signaling by activated point mutants of FGFR1 R-HSA-1839122 FGFR1 mutant receptor activation R-HSA-1839124 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signalling to p38 via RIT and RIN R-HSA-187706 Signaling by FGFR R-HSA-190236 FGFR1 ligand binding and activation R-HSA-190242 FGFR1b ligand binding and activation R-HSA-190370 FGFR1c ligand binding and activation R-HSA-190373 FGFR1c and Klotho ligand binding and activation R-HSA-190374 Signaling by VEGF R-HSA-194138 GRB2 events in ERBB2 signaling R-HSA-1963640 PI3K events in ERBB2 signaling R-HSA-1963642 PI3K/AKT activation R-HSA-198203 DAP12 interactions R-HSA-2172127 PI3K/AKT Signaling in Cancer R-HSA-2219528 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Signaling by Leptin R-HSA-2586552 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 FCERI mediated MAPK activation R-HSA-2871796 Signaling by GPCR R-HSA-372790 L1CAM interactions R-HSA-373760 NCAM signaling for neurite out-growth R-HSA-375165 Axon guidance R-HSA-422475 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signal transduction by L1 R-HSA-445144 Signaling by Interleukins R-HSA-449147 Interleukin-2 signaling R-HSA-451927 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 VEGFR2 mediated cell proliferation R-HSA-5218921 Phospholipase C-mediated cascade: FGFR1 R-HSA-5654219 Downstream signaling of activated FGFR1 R-HSA-5654687 SHC-mediated cascade:FGFR1 R-HSA-5654688 PI-3K cascade:FGFR1 R-HSA-5654689 FRS-mediated FGFR1 signaling R-HSA-5654693 PI-3K cascade:FGFR2 R-HSA-5654695 Downstream signaling of activated FGFR2 R-HSA-5654696 FRS-mediated FGFR2 signaling R-HSA-5654700 FRS-mediated FGFR3 signaling R-HSA-5654706 Downstream signaling of activated FGFR3 R-HSA-5654708 PI-3K cascade:FGFR3 R-HSA-5654710 FRS-mediated FGFR4 signaling R-HSA-5654712 Downstream signaling of activated FGFR4 R-HSA-5654716 PI-3K cascade:FGFR4 R-HSA-5654720 Negative regulation of FGFR1 signaling R-HSA-5654726 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 Signaling by FGFR1 in disease R-HSA-5655302 Signaling by FGFR1 mutants R-HSA-5655311 Diseases of signal transduction R-HSA-5663202 RAF/MAP kinase cascade R-HSA-5673001 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 Interleukin receptor SHC signaling R-HSA-912526 Signaling by the B Cell Receptor (BCR) R-HSA-983705","1652059 NAS GO:0005576 extracellular region IEA GO:0005634 nucleus IEA GO:0005829 cytosol 18480409 IDA GO:0005886 plasma membrane TAS GO:0005886 plasma membrane 10918587 TAS GO:0005887 integral component of plasma membrane 1652059 1846977 2159626 NAS GO:0016021 integral component of membrane IEA GO:0016023 cytoplasmic, membrane-bounded vesicle 23382219 IDA GO:0043235 receptor complex","negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA MAPK cascade GO:0000165 TAS skeletal system development 7874169 GO:0001501 TAS angiogenesis GO:0001525 IEA ureteric bud development GO:0001657 IEA in utero embryonic development GO:0001701 IEA organ induction GO:0001759 IEA neuron migration 15863030 GO:0001764 TAS positive regulation of mesenchymal cell proliferation GO:0002053 IEA chondrocyte differentiation GO:0002062 IEA transcription, DNA-templated GO:0006351 IEA protein phosphorylation 1846977 2159626 GO:0006468 NAS sensory perception of sound GO:0007605 IEA positive regulation of cell proliferation 8663044 GO:0008284 IDA positive regulation of cell proliferation 8663044 GO:0008284 IGI positive regulation of cell proliferation 8622701 GO:0008284 IMP fibroblast growth factor receptor signaling pathway 8663044 GO:0008543 IDA fibroblast growth factor receptor signaling pathway 8663044 GO:0008543 IGI fibroblast growth factor receptor signaling pathway 10830168 GO:0008543 IPI fibroblast growth factor receptor signaling pathway GO:0008543 TAS positive regulation of phospholipase activity 12141425 GO:0010518 TAS positive regulation of phospholipase C activity 18480409 GO:0010863 IDA positive regulation of neuron projection development GO:0010976 IEA regulation of phosphatidylinositol 3-kinase signaling GO:0014066 TAS positive regulation of phosphatidylinositol 3-kinase signaling 15863030 GO:0014068 TAS cell migration 15863030 GO:0016477 TAS peptidyl-tyrosine phosphorylation 8622701 18480409 GO:0018108 IDA stem cell population maintenance GO:0019827 IEA motogenic signaling involved in postnatal olfactory bulb interneuron migration GO:0021837 IEA ventricular zone neuroblast division GO:0021847 IEA embryonic limb morphogenesis GO:0030326 IEA midbrain development GO:0030901 IEA neuron projection development GO:0031175 IEA fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development GO:0035607 IEA phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IEA inner ear morphogenesis GO:0042472 IEA outer ear morphogenesis GO:0042473 IEA middle ear morphogenesis GO:0042474 IEA chordate embryonic development 15863030 GO:0043009 TAS positive regulation of MAP kinase activity 8622701 18480409 GO:0043406 IDA positive regulation of MAPK cascade 8622701 GO:0043410 IMP positive regulation of GTPase activity GO:0043547 IEA regulation of cell differentiation 12141425 GO:0045595 TAS positive regulation of neuron differentiation 8622701 GO:0045666 IMP negative regulation of osteoblast differentiation GO:0045668 IEA positive regulation of cell cycle GO:0045787 IEA protein autophosphorylation 8622701 GO:0046777 IDA phosphatidylinositol phosphorylation GO:0046854 IEA phosphatidylinositol-mediated signaling 12141425 GO:0048015 TAS paraxial mesoderm development GO:0048339 IEA regulation of lateral mesodermal cell fate specification GO:0048378 IEA cell maturation GO:0048469 IEA skeletal system morphogenesis 15863030 GO:0048705 TAS mesenchymal cell differentiation GO:0048762 IEA regulation of sensory perception of pain GO:0051930 IEA positive regulation of cardiac muscle cell proliferation GO:0060045 IEA auditory receptor cell development GO:0060117 IEA branching involved in salivary gland morphogenesis GO:0060445 IEA lung-associated mesenchyme development GO:0060484 IEA regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 IEA positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway GO:0090080 IEA positive regulation of endothelial cell chemotaxis to fibroblast growth factor 21885851 GO:2000546 IDA regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 IEA","glycoprotein binding IEA GO:0001948 protein tyrosine kinase activity IDA 8622701 GO:0004713 protein tyrosine kinase activity TAS GO:0004713 fibroblast growth factor-activated receptor activity IDA 18480409 20133753 GO:0005007 fibroblast growth factor-activated receptor activity TAS 2167437 GO:0005007 Ras guanyl-nucleotide exchange factor activity TAS GO:0005088 protein binding IPI 1656221 8321198 8753773 9660748 10464310 10490103 10830168 11030354 11401320 18412956 18441324 19665973 19696444 20932831 21765395 22035699 22751148 23597563 25241761 26267536 GO:0005515 ATP binding IEA GO:0005524 heparin binding IDA 18480409 GO:0008201 1-phosphatidylinositol-3-kinase activity TAS GO:0016303 fibroblast growth factor binding IDA 8663044 18480409 GO:0017134 protein complex binding IEA GO:0032403 identical protein binding IPI 19696444 GO:0042802 protein homodimerization activity IPI 20133753 GO:0042803 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS GO:0046934 cell adhesion molecule binding IEA GO:0050839",hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04520 Adherens junction - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05218 Melanoma - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human),CHEMBL CHEMBL3335604,P15328,Folate receptor alpha,1.0,PRIMARY,NO,NC1=Nc2[nH]c(CCCc3ccc(s3)C(=O)N[C@@H](CC(=O)O)C(=O)O)cc2C(=O)N1,4,8,"InChI=1S/C18H19N5O6S/c19-18-22-14-10(15(26)23-18)6-8(20-14)2-1-3-9-4-5-12(30-9)16(27)21-11(17(28)29)7-13(24)25/h4-6,11H,1-3,7H2,(H,21,27)(H,24,25)(H,28,29)(H4,19,20,22,23,26)/t11-/m0/s1",VLHCBXFJXATDOK-NSHDSACASA-N,"c(""KB"", ""Proton-coupled folate transporter"", ""Folate receptor beta"", ""Folate receptor alpha"", ""Folate transporter 1"")",2348,FOLR1,,GO:0000139 Golgi membrane TAS 23243496 GO:0005634 nucleus IDA GO:0005768 endosome IEA GO:0005789 endoplasmic reticulum membrane TAS 1840502 GO:0005886 plasma membrane NAS 10633085 GO:0005887 integral component of plasma membrane TAS 19581412 GO:0009986 cell surface IDA GO:0012507 ER to Golgi transport vesicle membrane TAS 2768245 GO:0016020 membrane TAS 10787414 GO:0016323 basolateral plasma membrane IDA 10787414 GO:0016324 apical plasma membrane IDA GO:0030136 clathrin-coated vesicle IEA 2527252 8033114 GO:0031362 anchored component of external side of plasma membrane IDA GO:0031526 brush border membrane IEA GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane TAS 19199708 23376485 23533145 GO:0070062 extracellular exosome IDA,heart looping GO:0001947 ISS neural crest cell migration involved in heart formation GO:0003147 ISS cardiac neural crest cell migration involved in outflow tract morphogenesis GO:0003253 ISS ER to Golgi vesicle-mediated transport GO:0006888 TAS receptor-mediated endocytosis GO:0006898 TAS 9545095 folic acid transport GO:0015884 IMP 8033114 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 ISS axon regeneration GO:0031103 ISS folic acid metabolic process GO:0046655 IEA COPII vesicle coating GO:0048208 TAS regulation of canonical Wnt signaling pathway GO:0060828 ISS pharyngeal arch artery morphogenesis GO:0061626 ISS anterior neural tube closure GO:0061713 ISS cellular response to folic acid GO:0071231 IDA 14722620,receptor activity GO:0004872 TAS 10633085 folic acid binding GO:0005542 IDA 2527252 10787414 14722620 23851396 folic acid binding GO:0005542 NAS 1840502 drug binding GO:0008144 IPI 19116913 folic acid transporter activity GO:0008517 IMP 8033114 methotrexate binding GO:0051870 IDA 19116913 folic acid receptor activity GO:0061714 IC 10787414,Endocytosis - Homo sapiens (human) hsa04144,CHEMBL CHEMBL267179,P21462,Formyl peptide receptor 1,1.0,PRIMARY,NO,CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O,2,12,"InChI=1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1",PRQROPMIIGLWRP-BZSNNMDCSA-N,"c(""Formyl peptide receptor 1"", ""Lipoxin A4 receptor"", ""FML2_HUMAN"", ""Unchecked"", ""Chromobox protein homolog 1"", ""Oligopeptide transporter small intestine isoform"", ""Geminin"")",2357,FPR1,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 Formyl peptide receptors bind formyl peptides and many other ligands R-HSA-444473 GPCR ligand binding R-HSA-500792,endosome TAS 10823817 GO:0005768 plasma membrane TAS GO:0005886 integral component of membrane IEA GO:0016021,TAS 10857861 activation of MAPK activity GO:0000187 TAS 10882119 movement of cell or subcellular component GO:0006928 IEA GO:0006935 chemotaxis TAS 10820279 signal transduction GO:0007165 TAS 10823817 G-protein coupled receptor signaling pathway GO:0007186 TAS 10889468 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007188 IDA 22859307 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 TAS 10861041 nitric oxide mediated signal transduction GO:0007263,TAS 10857861 receptor activity GO:0004872 IDA 12218158 22859307 N-formyl peptide receptor activity GO:0004982 IPI 22447027 protein binding GO:0005515 IEA GO:0050786 RAGE receptor binding,hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa05150 Staphylococcus aureus infection - Homo sapiens (human),CHEMBL CHEMBL2385460,O14842,Free fatty acid receptor 1,1.0,ORTHOGONAL,YES,COc1ccc(F)c(c1)c2ccc(COc3ccc4CC[C@]5(C[C@H]5C(=O)O)c4c3)cc2[C@@H]6CCCC6(C)C,7,8,"InChI=1S/C33H35FO4/c1-32(2)13-4-5-27(32)25-15-20(6-10-24(25)26-16-22(37-3)9-11-30(26)34)19-38-23-8-7-21-12-14-33(28(21)17-23)18-29(33)31(35)36/h6-11,15-17,27,29H,4-5,12-14,18-19H2,1-3H3,(H,35,36)/t27-,29-,33-/m0/s1",XPLWBHWPOUEOSJ-GSZYCOFVSA-N,"c(""Dopamine D1 receptor"", ""Histamine H4 receptor"", ""Cholecystokinin B receptor"", ""Norepinephrine transporter"", ""Thyrotropin-releasing hormone receptor"", ""Adenosine A1 receptor"", ""Free fatty acid receptor 1"")",2864,FFAR1,R-HSA-1430728 Metabolism R-HSA-162582 Signal Transduction R-HSA-163685 Integration of energy metabolism R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signaling R-HSA-400451 Free fatty acids regulate insulin secretion R-HSA-416476 G alpha (q) signalling events R-HSA-422356 Regulation of insulin secretion R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-444209 Free fatty acid receptors R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,GO:0005886 plasma membrane 24130766 IDA GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 25043059 IDA,IEA GO:0007186 G-protein coupled receptor signaling pathway IEA GO:0030073 insulin secretion IEA GO:0032024 positive regulation of insulin secretion IEA GO:0042593 glucose homeostasis IEA GO:0043547 positive regulation of GTPase activity 24130766 IDA GO:0051928 positive regulation of calcium ion transport 24130766 IDA GO:0070542 response to fatty acid,9344866 TAS GO:0004930 G-protein coupled receptor activity TAS GO:0005085 guanyl-nucleotide exchange factor activity IEA GO:0008289 lipid binding 24130766 IDA GO:0045125 bioactive lipid receptor activity,Insulin secretion - Homo sapiens (human) hsa04911,CHEMBL CHEMBL207881,O14842,Free fatty acid receptor 1,1.0,PRIMARY,YES,OC(=O)CCc1ccc(NCc2cccc(Oc3ccccc3)c2)cc1,12,58,"InChI=1S/C22H21NO3/c24-22(25)14-11-17-9-12-19(13-10-17)23-16-18-5-4-8-21(15-18)26-20-6-2-1-3-7-20/h1-10,12-13,15,23H,11,14,16H2,(H,24,25)",DGENZVKCTGIDRZ-UHFFFAOYSA-N,"c(""Free fatty acid receptor 1"", ""Free fatty acid receptor 3"", ""Free fatty acid receptor 2"", ""Hydroxycarboxylic acid receptor 2"", ""Sphingosine 1-phosphate receptor Edg-1"", ""Peroxisome proliferator-activated receptor alpha"", ""Peroxisome proliferator-activated receptor delta"", ""Peroxisome proliferator-activated receptor gamma"", ""Prostanoid EP1 receptor"", ""Prostanoid EP3 receptor"", ""Prostanoid EP4 receptor"", ""Unchecked"", ""Tyrosyl-DNA phosphodiesterase 1"", ""Lysine-specific demethylase 4A"", ""Vitamin D receptor"", ""G-protein coupled receptor 120"", ""Geminin"", ""DNA-(apurinic or apyrimidinic site) lyase"")",2864,FFAR1,R-HSA-1430728 Metabolism R-HSA-162582 Signal Transduction R-HSA-163685 Integration of energy metabolism R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signaling R-HSA-400451 Free fatty acids regulate insulin secretion R-HSA-416476 G alpha (q) signalling events R-HSA-422356 Regulation of insulin secretion R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion R-HSA-444209 Free fatty acid receptors R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,GO:0005886 plasma membrane 24130766 IDA GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 25043059 IDA,IEA GO:0007186 G-protein coupled receptor signaling pathway IEA GO:0030073 insulin secretion IEA GO:0032024 positive regulation of insulin secretion IEA GO:0042593 glucose homeostasis IEA GO:0043547 positive regulation of GTPase activity 24130766 IDA GO:0051928 positive regulation of calcium ion transport 24130766 IDA GO:0070542 response to fatty acid,9344866 TAS GO:0004930 G-protein coupled receptor activity TAS GO:0005085 guanyl-nucleotide exchange factor activity IEA GO:0008289 lipid binding 24130766 IDA GO:0045125 bioactive lipid receptor activity,Insulin secretion - Homo sapiens (human) hsa04911,CHEMBL CHEMBL35571,P31644,GABA receptor alpha-5 subunit,1.0,PRIMARY,NO,CN1Cc2c(ncn2c3ccc(cc3C1=O)C#C)C(=O)OCCCOC(=O)c4ncn5c4CN(C)C(=O)c6cc(ccc56)C#C,6,20,"InChI=1S/C33H26N6O6/c1-5-20-8-10-24-22(14-20)30(40)36(3)16-26-28(34-18-38(24)26)32(42)44-12-7-13-45-33(43)29-27-17-37(4)31(41)23-15-21(6-2)9-11-25(23)39(27)19-35-29/h1-2,8-11,14-15,18-19H,7,12-13,16-17H2,3-4H3",JYRRJDFICVOODX-UHFFFAOYSA-N,"c(""GABA-A receptor; alpha-1/beta-3/gamma-2"", ""GABA-A receptor; alpha-2/beta-3/gamma-2"", ""Unchecked"", ""GABA A receptor alpha-4/beta-3/gamma-2"", ""GABA-A receptor; alpha-5/beta-3/gamma-2"", ""GABA-A receptor; alpha-6/beta-3/gamma-2"", ""GABA-A receptor; alpha-3/beta-3/gamma-2"", ""GABA receptor alpha-6 subunit"", ""GABA receptor alpha-5 subunit"", ""GABA receptor alpha-4 subunit"", ""GABA receptor alpha-3 subunit"", ""GABA receptor alpha-2 subunit"", ""GABA receptor alpha-1 subunit"", ""Histone acetyltransferase GCN5"", ""DNA-(apurinic or apyrimidinic site) lyase"")",2558,GBRA5,R-HSA-112314 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System R-HSA-382551 Transmembrane transport of small molecules R-HSA-975298 Ligand-gated ion channel transport R-HSA-977441 GABA A receptor activation R-HSA-977443 GABA receptor activation R-HSA-983712 Ion channel transport,plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 TAS 1321750 cell junction GO:0030054 IEA dendrite GO:0030425 IEA neuronal cell body membrane GO:0032809 IEA chloride channel complex GO:0034707 IEA postsynaptic membrane GO:0045211 IEA GABA-A receptor complex GO:1902711 IBA,behavioral fear response GO:0001662 IEA positive regulation of defense response to virus by host GO:0002230 22020285 IMP transport GO:0006810 1321750 TAS signal transduction GO:0007165 1321750 TAS gamma-aminobutyric acid signaling pathway GO:0007214 IEA chemical synaptic transmission GO:0007268 IEA brain development GO:0007420 IEA sensory perception of sound GO:0007605 IEA associative learning GO:0008306 IEA ion transmembrane transport GO:0034220 TAS negative regulation of neuron apoptotic process GO:0043524 IEA inner ear receptor cell development GO:0060119 IEA innervation GO:0060384 IEA cochlea development GO:0090102 IEA mitophagy in response to mitochondrial depolarization GO:0098779 22020285 IGI xenophagy GO:0098792 22020285 IMP chloride transmembrane transport GO:1902476 IEA,receptor activity GO:0004872 1321750 TAS GABA-A receptor activity GO:0004890 IBA contributes_to transporter activity GO:0005215 1321750 TAS extracellular ligand-gated ion channel activity GO:0005230 IEA chloride channel activity GO:0005254 IEA GABA receptor binding GO:0050811 IEA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04727 GABAergic synapse - Homo sapiens (human) hsa05032 Morphine addiction - Homo sapiens (human) hsa05033 Nicotine addiction - Homo sapiens (human),CHEMBL CHEMBL1641613,P30531,GABA transporter 1,1.0,PRIMARY,NO,Cc1ccccc1\C(=C/CCN2CCC[C@H](C2)C(=O)O)\c3ccccc3F,4,4,"InChI=1S/C23H26FNO2/c1-17-8-2-3-10-19(17)20(21-11-4-5-13-22(21)24)12-7-15-25-14-6-9-18(16-25)23(26)27/h2-5,8,10-13,18H,6-7,9,14-16H2,1H3,(H,26,27)/b20-12+/t18-/m1/s1",XZCPNRFCLBNHOY-BAOGCXAUSA-N,"c(""GABA transporter 1"", ""Betaine transporter"", ""GABA transporter 2"", ""GABA transporter 3"")",6529,SC6A1,"R-HSA-112310 Neurotransmitter Release Cycle R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System R-HSA-382551 Transmembrane transport of small molecules R-HSA-425366 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds R-HSA-425407 SLC-mediated transmembrane transport R-HSA-425428 Amine compound SLC transporters R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters R-HSA-888590 GABA synthesis, release, reuptake and degradation R-HSA-888593 Reuptake of GABA",TAS GO:0005886 plasma membrane IBA GO:0005887 integral component of plasma membrane IEA GO:0009986 cell surface TAS 2387399 membrane GO:0016020 TAS 8530094 integral component of membrane GO:0016021 IEA GO:0030424 axon IBA GO:0043005 neuron projection,"transport 8530094 GO:0006810 NAS neurotransmitter transport GO:0006836 IBA chemical synaptic transmission 8530094 GO:0007268 TAS learning GO:0007612 IEA response to toxic substance GO:0009636 IEA response to sucrose GO:0009744 IEA response to lead ion GO:0010288 IEA positive regulation of gamma-aminobutyric acid secretion GO:0014054 IEA response to purine-containing compound GO:0014074 IEA gamma-aminobutyric acid transport GO:0015812 IBA negative regulation of synaptic transmission, GABAergic GO:0032229 IEA response to estradiol GO:0032355 IEA response to cocaine GO:0042220 IEA protein homooligomerization GO:0051260 IEA response to calcium ion GO:0051592 IEA gamma-aminobutyric acid import GO:0051939 IEA transmembrane transport GO:0055085 IEA mitophagy in response to mitochondrial depolarization 22020285 GO:0098779 IGI",GO:0005328 neurotransmitter:sodium symporter activity IEA GO:0005332 gamma-aminobutyric acid:sodium symporter activity IBA GO:0005332 gamma-aminobutyric acid:sodium symporter activity TAS GO:0046872 metal ion binding IEA,hsa04727 GABAergic synapse - Homo sapiens (human),CHEMBL CHEMBL365307,P22102,GAR transformylase,1.0,PRIMARY,NO,NC1=Nc2[nH]c(CCCCc3ccc(cc3)C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc2C(=O)N1,4,42,"InChI=1S/C22H25N5O6/c23-22-26-18-15(20(31)27-22)11-14(24-18)4-2-1-3-12-5-7-13(8-6-12)19(30)25-16(21(32)33)9-10-17(28)29/h5-8,11,16H,1-4,9-10H2,(H,25,30)(H,28,29)(H,32,33)(H4,23,24,26,27,31)/t16-/m0/s1",CEPQCJFDTGQKDN-INIZCTEOSA-N,"c(""Dihydrofolate reductase"", ""CCRF-CEM"", ""HL-60"", ""SR"", ""K562"", ""SW-620"", ""786-0"", ""Thymidylate synthase"", ""Unchecked"", ""R2"", ""KB"", ""IGROV-1"", ""GAR transformylase"", ""Folate transporter 1"")",2618,PUR2,Metabolism R-HSA-1430728 Metabolism of nucleotides R-HSA-15869 Purine ribonucleoside monophosphate biosynthesis R-HSA-73817 Purine metabolism R-HSA-73847,TAS GO:0005829 cytosol 20458337 IDA GO:0070062 extracellular exosome,GO:0003360 brainstem development IEA GO:0006189 'de novo' IMP biosynthetic process IEA GO:0006544 glycine metabolic process IEA GO:0009113 purine nucleobase biosynthetic process IEA GO:0009168 purine ribonucleoside monophosphate biosynthetic process TAS GO:0010033 response to organic substance IEA GO:0010035 response to inorganic substance IEA GO:0021549 cerebellum development IEA GO:0021987 cerebral cortex development IEA GO:0046654 tetrahydrofolate biosynthetic process IEA,GO:0004637 phosphoribosylamine-glycine ligase activity TAS GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity TAS GO:0004644 phosphoribosylglycinamide formyltransferase activity TAS GO:0005524 ATP binding IEA GO:0046872 metal ion binding IEA,Purine metabolism - Homo sapiens (human) hsa00230 One carbon pool by folate - Homo sapiens (human) hsa00670,CHEMBL CHEMBL3586032,Q92847,Ghrelin receptor,1.0,ORTHOGONAL,NO,CC(=O)N1[C@@H]2CC[C@H]1C=C(C2)c3cnc(NCc4ccc5CCOc5c4)c(c3)C(=O)NC[C@H]6COc7ccccc7O6,7,10,"InChI=1S/C33H34N4O5/c1-20(38)37-25-8-9-26(37)14-23(13-25)24-15-28(33(39)36-18-27-19-41-29-4-2-3-5-30(29)42-27)32(35-17-24)34-16-21-6-7-22-10-11-40-31(22)12-21/h2-7,12-13,15,17,25-27H,8-11,14,16,18-19H2,1H3,(H,34,35)(H,36,39)/t25-,26+,27-/m0/s1",UZJCBPUZLIMFRR-VJGNERBWSA-N,"c(""Serotonin 2c (5-HT2c) receptor"", ""Neuropeptide Y receptor type 1"", ""Motilin receptor"", ""Melanocortin receptor 4"", ""Dopamine D2 receptor"", ""Dopamine D1 receptor"", ""Unchecked"", ""Ghrelin receptor"")",2693,GHSR,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,plasma membrane GO:0005886 TAS cell surface GO:0009986 8688086 IDA integral component of membrane GO:0016021 IEA neuron projection GO:0043005 12890514 IDA membrane raft GO:0045121 15232612 IDA,G-protein coupled receptor signaling pathway IDA 8688086 GO:0007186 actin polymerization or depolymerization IDA 15232612 GO:0008154 adult feeding behavior ISS GO:0008343 response to hormone IDA 15232612 GO:0009725 hormone-mediated signaling pathway IDA 8688086 GO:0009755 growth hormone secretion TAS 16511605 GO:0030252 response to food IEA GO:0032094 positive regulation of appetite ISS GO:0032100 negative regulation of interleukin-1 beta production IDA 15232612 GO:0032691 cellular response to insulin stimulus IEA GO:0032869 positive regulation of multicellular organism growth IMP 16511605 GO:0040018 negative regulation of tumor necrosis factor biosynthetic process IDA 15232612 GO:0042536 regulation of hindgut contraction IEA GO:0043134 positive regulation of insulin-like growth factor receptor signaling pathway IEA GO:0043568 negative regulation of interleukin-6 biosynthetic process IDA 15232612 GO:0045409 positive regulation of fatty acid metabolic process IEA GO:0045923 negative regulation of insulin secretion IEA GO:0046676 decidualization IDA 17494105 GO:0046697 negative regulation of inflammatory response IDA 15232612 GO:0050728 regulation of synapse assembly IEA GO:0051963,growth hormone secretagogue receptor activity GO:0001616 IDA 8688086 G-protein coupled receptor activity GO:0004930 IDA 8688086 growth hormone-releasing hormone receptor activity GO:0016520 IDA 8688086 peptide hormone binding GO:0017046 IEA,hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL243001,Q92847,Ghrelin receptor,1.0,PRIMARY,NO,CC(C)N1CCC[C@H](CN2C(=Nc3ccc(Oc4ccc(F)cc4)cc3C2=O)C)C1,7,12,"InChI=1S/C24H28FN3O2/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3/t18-/m0/s1",FRKXOBMDEXCHHD-SFHVURJKSA-N,"c(""Serotonin 2c (5-HT2c) receptor"", ""Ghrelin receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 2b (5-HT2b) receptor"", ""Motilin receptor"", ""Unchecked"", ""Muscarinic acetylcholine receptor M1"", ""Muscarinic acetylcholine receptor M2"")",2693,GHSR,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,plasma membrane GO:0005886 TAS cell surface GO:0009986 8688086 IDA integral component of membrane GO:0016021 IEA neuron projection GO:0043005 12890514 IDA membrane raft GO:0045121 15232612 IDA,G-protein coupled receptor signaling pathway IDA 8688086 GO:0007186 actin polymerization or depolymerization IDA 15232612 GO:0008154 adult feeding behavior ISS GO:0008343 response to hormone IDA 15232612 GO:0009725 hormone-mediated signaling pathway IDA 8688086 GO:0009755 growth hormone secretion TAS 16511605 GO:0030252 response to food IEA GO:0032094 positive regulation of appetite ISS GO:0032100 negative regulation of interleukin-1 beta production IDA 15232612 GO:0032691 cellular response to insulin stimulus IEA GO:0032869 positive regulation of multicellular organism growth IMP 16511605 GO:0040018 negative regulation of tumor necrosis factor biosynthetic process IDA 15232612 GO:0042536 regulation of hindgut contraction IEA GO:0043134 positive regulation of insulin-like growth factor receptor signaling pathway IEA GO:0043568 negative regulation of interleukin-6 biosynthetic process IDA 15232612 GO:0045409 positive regulation of fatty acid metabolic process IEA GO:0045923 negative regulation of insulin secretion IEA GO:0046676 decidualization IDA 17494105 GO:0046697 negative regulation of inflammatory response IDA 15232612 GO:0050728 regulation of synapse assembly IEA GO:0051963,growth hormone secretagogue receptor activity GO:0001616 IDA 8688086 G-protein coupled receptor activity GO:0004930 IDA 8688086 growth hormone-releasing hormone receptor activity GO:0016520 IDA 8688086 peptide hormone binding GO:0017046 IEA,hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL1094208,P04150,Glucocorticoid receptor,1.0,PRIMARY,NO,OC(c1ccc2c(cnn2c3ccc(F)cc3)c1)(c4cccc(Cl)c4Cl)C(F)(F)F,17,39,"InChI=1S/C21H12Cl2F4N2O/c22-17-3-1-2-16(19(17)23)20(30,21(25,26)27)13-4-9-18-12(10-13)11-28-29(18)15-7-5-14(24)6-8-15/h1-11,30H",SGKVPHOMCZNDPT-UHFFFAOYSA-N,"c(""Glucocorticoid receptor"", ""Adenosine A1 receptor"", ""Adenosine A2a receptor"", ""Alpha-1a adrenergic receptor"", ""Alpha-1b adrenergic receptor"", ""Alpha-2a adrenergic receptor"", ""Beta-1 adrenergic receptor"", ""Beta-2 adrenergic receptor"", ""Unchecked"", ""Dopamine D1 receptor"", ""Dopamine D2 receptor"", ""Histamine H1 receptor"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M3"", ""Mu opioid receptor"", ""Prostanoid EP4 receptor"", ""Sigma opioid receptor"", ""Norepinephrine transporter"" )",2908,GCR,R-HSA-212436 Generic Transcription Pathway R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-74160 Gene Expression,nucleus 15769988 17635946 23878391 GO:0005634 IDA nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS cytoplasm 15769988 17635946 GO:0005737 IDA mitochondrial matrix 10887960 GO:0005759 TAS microtubule organizing center GO:0005815 IEA spindle GO:0005819 IEA,"GO:0006351 transcription, DNA-templated 10887960 TAS GO:0006355 regulation of transcription, DNA-templated 19141540 IDA GO:0006366 transcription from RNA polymerase II promoter 8621628 TAS GO:0006367 transcription initiation from RNA polymerase II promoter TAS GO:0006915 apoptotic process IEA GO:0007059 chromosome segregation IEA GO:0007067 mitotic nuclear division IEA GO:0007165 signal transduction 7769088 TAS GO:0016568 chromatin modification IEA GO:0042921 glucocorticoid receptor signaling pathway IEA GO:0043402 glucocorticoid mediated signaling pathway IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter 15769988 16728402 23823477 IDA GO:0051301 cell division IEA GO:0071383 cellular response to steroid hormone stimulus 15769988 17635946 IDA","IDA 16728402 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA 16728402 23823477 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 IDA 15769988 17635946 transcription factor activity, sequence-specific DNA binding GO:0003700 IEA GO:0003723 RNA binding TAS 8621628 glucocorticoid receptor activity GO:0004883 IDA 15769988 steroid binding GO:0005496 IPI 9079630 10364267 11266503 12552091 12773562 15591535 15769988 15941832 16606617 16619302 16888650 17003263 17635946 17978169 19141540 20195357 21980503 22170608 23339905 24291004 24658140 24949977 protein binding GO:0005515 IEA GO:0008270 zinc ion binding IDA 17635946 glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity GO:0038051 IDA 17635946 steroid hormone binding GO:1990239",Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL2086690,Q8TDV5,Glucose-dependent insulinotropic receptor,1.0,PRIMARY,NO,CC(C)c1onc(n1)N2CCN([C@H](C)C2)c3ncc(OCc4ccncc4C#N)cn3,4,11,"InChI=1S/C21H24N8O2/c1-14(2)19-26-21(27-31-19)28-6-7-29(15(3)12-28)20-24-10-18(11-25-20)30-13-16-4-5-23-9-17(16)8-22/h4-5,9-11,14-15H,6-7,12-13H2,1-3H3/t15-/m1/s1",UNGZTVLHLKAKQE-OAHLLOKOSA-N,"c(""Synaptic vesicular amine transporter"", ""Serotonin 2b (5-HT2b) receptor"", ""Unchecked"", ""Acetylcholinesterase"", ""Glucose-dependent insulinotropic receptor"")",139760,GP119,,GO:0005886 plasma membrane IEA GO:0016021 integral component of membrane IEA 23382219 GO:0043235 receptor complex IDA,G-protein coupled receptor signaling pathway GO:0007186 IEA insulin secretion GO:0030073 IEA,IEA GO:0004930 G-protein coupled receptor activity IEA GO:0031210 phosphatidylcholine binding,cAMP signaling pathway - Homo sapiens (human) hsa04024 Insulin secretion - Homo sapiens (human) hsa04911,CHEMBL CHEMBL48029,Q13224,Glutamate [NMDA] receptor subunit epsilon 2,1.0,PRIMARY,NO,C(Cc1ccc(OCc2ccccc2)cc1)Nc3ccncc3,3,4,"InChI=1S/C20H20N2O/c1-2-4-18(5-3-1)16-23-20-8-6-17(7-9-20)10-15-22-19-11-13-21-14-12-19/h1-9,11-14H,10,15-16H2,(H,21,22)",WPBRSJXCRWSAHJ-UHFFFAOYSA-N,"c(""Thrombin"", ""Glutamate [NMDA] receptor subunit epsilon 2"", ""Glutamate [NMDA] receptor subunit epsilon 1"")",2904,NMDE2,"R-HSA-112314 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System R-HSA-112399 IRS-mediated signalling R-HSA-112412 SOS-mediated signalling R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250196 SHC1 events in ERBB2 signaling R-HSA-1250347 SHC1 events in ERBB4 signaling R-HSA-1266738 Developmental Biology R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1433557 Signaling by SCF-KIT R-HSA-162582 Signal Transduction R-HSA-166520 Signalling by NGF R-HSA-167044 Signalling to RAS R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-169893 Prolonged ERK activation events R-HSA-170968 Frs2-mediated activation R-HSA-170984 ARMS-mediated activation R-HSA-177929 Signaling by EGFR R-HSA-179812 GRB2 events in EGFR signaling R-HSA-180336 SHC1 events in EGFR signaling R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-187687 Signalling to ERKs R-HSA-187706 Signalling to p38 via RIT and RIN R-HSA-190236 Signaling by FGFR R-HSA-194138 Signaling by VEGF R-HSA-1963640 GRB2 events in ERBB2 signaling R-HSA-2172127 DAP12 interactions R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2586552 Signaling by Leptin R-HSA-2682334 EPH-Ephrin signaling R-HSA-2871796 FCERI mediated MAPK activation R-HSA-372790 Signaling by GPCR R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-3928662 EPHB-mediated forward signaling R-HSA-422475 Axon guidance R-HSA-438064 Post NMDA receptor activation events R-HSA-438066 Unblocking of NMDA receptor, glutamate binding and activation R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-442729 CREB phosphorylation through the activation of CaMKII R-HSA-442742 CREB phosphorylation through the activation of Ras R-HSA-442755 Activation of NMDA receptor upon glutamate binding and postsynaptic events R-HSA-442982 Ras activation uopn Ca2+ infux through NMDA receptor R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5683057 MAPK family signaling cascades R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-912526 Interleukin receptor SHC signaling",intracellular IEA GO:0005622 plasma membrane TAS GO:0005886 integral component of plasma membrane TAS 8768735 GO:0005887 cell surface ISS GO:0009986 NMDA selective glutamate receptor complex IDA 10480938 17047094 GO:0017146 cell junction IEA GO:0030054 neuron projection ISS GO:0043005 postsynaptic membrane IEA GO:0045211,TAS GO:0000165 MAPK cascade TAS 8768735 transport GO:0006810 TAS 8768735 glutamate receptor signaling pathway GO:0007215 TAS GO:0007268 chemical synaptic transmission TAS 10485705 learning or memory GO:0007611 IEA GO:0034220 ion transmembrane transport IEA GO:0035235 ionotropic glutamate receptor signaling pathway IEA GO:0043547 positive regulation of GTPase activity IDA 18445116 response to ethanol GO:0045471 TAS GO:0048013 ephrin receptor signaling pathway,NMDA glutamate receptor activity GO:0004972 8768735 TAS Ras guanyl-nucleotide exchange factor activity GO:0005088 TAS extracellular-glutamate-gated ion channel activity GO:0005234 IEA protein binding GO:0005515 11937501 17047094 17997397 19453375 IPI zinc ion binding GO:0008270 ISS glycine binding GO:0016594 17047094 IDA,"hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04713 Circadian entrainment - Homo sapiens (human) hsa04720 Long-term potentiation - Homo sapiens (human) hsa04724 Glutamatergic synapse - Homo sapiens (human) hsa04728 Dopaminergic synapse - Homo sapiens (human) hsa05010 Alzheimer,s disease - Homo sapiens (human) hsa05014 Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) hsa05016 Huntington,s disease - Homo sapiens (human) hsa05030 Cocaine addiction - Homo sapiens (human) hsa05031 Amphetamine addiction - Homo sapiens (human) hsa05033 Nicotine addiction - Homo sapiens (human) hsa05034 Alcoholism - Homo sapiens (human) hsa05322 Systemic lupus erythematosus - Homo sapiens (human)",CHEMBL CHEMBL63861,P39086,Glutamate receptor ionotropic kainate 1,1.0,PRIMARY,NO,OC(=O)CN1C(=O)C(=O)Nc2cc(c(cc12)n3ccc(CN4CCN(Cc5ccccc5)CC4)c3)[N+](=O)[O-],4,4,"InChI=1S/C26H26N6O6/c33-24(34)17-31-21-13-22(23(32(37)38)12-20(21)27-25(35)26(31)36)30-7-6-19(16-30)15-29-10-8-28(9-11-29)14-18-4-2-1-3-5-18/h1-7,12-13,16H,8-11,14-15,17H2,(H,27,35)(H,33,34)",UWBHJOVXAJRYJM-UHFFFAOYSA-N,"c(""Glutamate receptor ionotropic kainate 1"", ""Glutamate receptor ionotropic kainate 2"", ""Glutamate receptor ionotropic kainate 3"", ""Glutamate receptor ionotropic kainate 5"")",2897,GRIK1,R-HSA-112314 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System R-HSA-451306 Ionotropic activity of Kainate Receptors R-HSA-451307 Activation of Na-permeable Kainate Receptors R-HSA-451308 Activation of Ca-permeable Kainate Receptor R-HSA-451326 Activation of Kainate Receptors upon glutamate binding,GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 8260617 TAS GO:0030054 cell junction IEA GO:0045211 postsynaptic membrane IEA,"8260617 TAS GO:0006810 transport 8260617 TAS GO:0007215 glutamate receptor signaling pathway 10580501 TAS GO:0007268 chemical synaptic transmission 8260617 TAS GO:0007399 nervous system development 10580501 TAS GO:0007417 central nervous system development IEA GO:0034220 ion transmembrane transport IEA GO:0035235 ionotropic glutamate receptor signaling pathway 9335499 TAS GO:0051966 regulation of synaptic transmission, glutamatergic",extracellular-glutamate-gated ion channel activity GO:0005234 IEA ligand-gated ion channel activity GO:0015276 TAS kainate selective glutamate receptor activity 9335499 GO:0015277 IDA,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Glutamatergic synapse - Homo sapiens (human) hsa04724,CHEMBL CHEMBL121915,Q16478,Glutamate receptor ionotropic kainate 5,1.0,PRIMARY,NO,N[C@@H](CN1C=C(I)C(=O)NC1=O)C(=O)O,4,12,"InChI=1S/C7H8IN3O4/c8-3-1-11(2-4(9)6(13)14)7(15)10-5(3)12/h1,4H,2,9H2,(H,13,14)(H,10,12,15)/t4-/m0/s1",AXXYLTBQIQBTES-BYPYZUCNSA-N,"c(""Glutamate receptor ionotropic, AMPA 1"", ""Glutamate receptor ionotropic, AMPA 2"", ""Glutamate receptor ionotropic, AMPA 4"", ""Glutamate receptor ionotropic kainate 5"", ""Histone-lysine N-methyltransferase MLL"", ""Bloom syndrome protein"", ""Endoplasmic reticulum-associated amyloid beta-peptide-binding protein"", ""Histone-lysine N-methyltransferase, H3 lysine-9 specific 3"", ""Unchecked"")",2901,GRIK5,Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-112314 Transmission across Chemical Synapses R-HSA-112315 Neuronal System R-HSA-112316 Ionotropic activity of Kainate Receptors R-HSA-451306 Activation of Ca-permeable Kainate Receptor R-HSA-451308 Activation of Kainate Receptors upon glutamate binding R-HSA-451326,endoplasmic reticulum GO:0005783 IEA plasma membrane GO:0005886 TAS postsynaptic density GO:0014069 IEA cell junction GO:0030054 IEA dendrite GO:0030425 IEA kainate selective glutamate receptor complex GO:0032983 IEA presynaptic membrane GO:0042734 IEA terminal bouton GO:0043195 IEA perikaryon GO:0043204 IEA postsynaptic membrane GO:0045211 IEA,"protein retention in ER lumen GO:0006621 IEA regulation of synaptic vesicle fusion to presynaptic membrane GO:0031630 IEA ion transmembrane transport GO:0034220 IEA ionotropic glutamate receptor signaling pathway GO:0035235 IEA synaptic transmission, glutamatergic GO:0035249 IEA receptor clustering GO:0043113 IEA positive regulation of neuron apoptotic process GO:0043525 IEA establishment of localization in cell GO:0051649 IEA excitatory postsynaptic potential GO:0060079 IEA cellular response to glucose stimulus GO:0071333 IEA",GO:0005234 extracellular-glutamate-gated ion channel activity IEA GO:0015276 ligand-gated ion channel activity TAS 1321949 GO:0015277 kainate selective glutamate receptor activity IDA GO:0017124 SH3 domain binding IEA GO:0030165 PDZ domain binding IEA GO:0042802 identical protein binding IEA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04724 Glutamatergic synapse - Homo sapiens (human),CHEMBL CHEMBL180966,P48067,Glycine transporter 1,1.0,ORTHOGONAL,NO,CN(CC[C@@H](Oc1ccc(cc1)c2ccccc2)c3ccc(F)cc3)CC(=O)O,3,10,"InChI=1S/C24H24FNO3/c1-26(17-24(27)28)16-15-23(20-7-11-21(25)12-8-20)29-22-13-9-19(10-14-22)18-5-3-2-4-6-18/h2-14,23H,15-17H2,1H3,(H,27,28)/t23-/m1/s1",FDORQEIHOKEJNX-HSZRJFAPSA-N,"c(""Glycine transporter 1"", ""Glycine transporter 2"", ""T98G"", ""Microtubule-associated protein tau"", ""Aldehyde dehydrogenase 1A1"", ""Unchecked"", ""Ubiquitin carboxyl-terminal hydrolase 1"")",6536,SC6A9,"R-HSA-382551 Transmembrane transport of small molecules R-HSA-425366 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds R-HSA-425407 SLC-mediated transmembrane transport R-HSA-425428 Amine compound SLC transporters R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters",TAS GO:0005886 plasma membrane IEA GO:0005887 integral component of plasma membrane TAS 8183239 membrane GO:0016020 IEA GO:0098793 presynapse,"amino acid transmembrane transport GO:0003333 IEA transport 8183239 GO:0006810 TAS glycine import GO:0036233 IBA synaptic transmission, glycinergic GO:0060012 IBA glycine secretion, neurotransmission GO:0061537 IEA",neurotransmitter:sodium symporter activity IEA GO:0005328 glycine:sodium symporter activity TAS GO:0015375,,CHEMBL CHEMBL526648,P48067,Glycine transporter 1,1.0,PRIMARY,NO,CC(=O)c1ccc(N2CCN(CC2)C(=O)c3cc(ccc3N4CCOCC4)S(=O)(=O)C)c(F)c1,5,7,"InChI=1S/C24H28FN3O5S/c1-17(29)18-3-5-23(21(25)15-18)26-7-9-28(10-8-26)24(30)20-16-19(34(2,31)32)4-6-22(20)27-11-13-33-14-12-27/h3-6,15-16H,7-14H2,1-2H3",TUPJMQWUSDJIDL-UHFFFAOYSA-N,"c(""Glycine transporter 1"", ""Glycine transporter 2"", ""Unchecked"", ""Monoamine oxidase A"", ""Catechol O-methyltransferase"", ""Acetylcholinesterase"")",6536,SC6A9,"R-HSA-382551 Transmembrane transport of small molecules R-HSA-425366 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds R-HSA-425407 SLC-mediated transmembrane transport R-HSA-425428 Amine compound SLC transporters R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters",TAS GO:0005886 plasma membrane IEA GO:0005887 integral component of plasma membrane TAS 8183239 membrane GO:0016020 IEA GO:0098793 presynapse,"amino acid transmembrane transport GO:0003333 IEA transport 8183239 GO:0006810 TAS glycine import GO:0036233 IBA synaptic transmission, glycinergic GO:0060012 IBA glycine secretion, neurotransmission GO:0061537 IEA",neurotransmitter:sodium symporter activity IEA GO:0005328 glycine:sodium symporter activity TAS GO:0015375,,CHEMBL CHEMBL460480,P30968,Gonadotropin-releasing hormone receptor,1.0,PRIMARY,NO,CCN1C=C(CN2CCN(CC2)c3cccc4[nH]c(nc34)c5ccc(cc5)C(C)(C)C)C(=O)NC1=O,2,7,"InChI=1S/C28H34N6O2/c1-5-33-18-20(26(35)31-27(33)36)17-32-13-15-34(16-14-32)23-8-6-7-22-24(23)30-25(29-22)19-9-11-21(12-10-19)28(2,3)4/h6-12,18H,5,13-17H2,1-4H3,(H,29,30)(H,31,35,36)",YJBAGQATRBRFBC-UHFFFAOYSA-N,"c(""Gonadotropin-releasing hormone receptor"", ""Unchecked"", ""Serotonin 2a (5-HT2a) receptor"")",2798,GNRHR,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Hormone ligand-binding receptors R-HSA-375281 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,TAS GO:0005886 plasma membrane 8386108 TAS GO:0005887 integral component of plasma membrane 9259321 TAS GO:0016020 membrane,GO:0007186 G-protein coupled receptor signaling pathway IEA 10686191 GO:0007275 multicellular organism development TAS GO:0097211 cellular response to gonadotropin-releasing hormone IEA,GO:0004968 gonadotropin-releasing hormone receptor activity IEA GO:0042277 peptide binding IBA,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 GnRH signaling pathway - Homo sapiens (human) hsa04912,CHEMBL CHEMBL3234871,Q8TDU6,G-protein coupled bile acid receptor 1,1.0,PRIMARY,YES,OC(=O)[C@@H]1CC[C@H](CC1)c2ccc(cc2)c3cc(nc(n3)C(F)(F)F)N4CC[C@H]4C(=O)NCCc5ccc(cc5)C#N,4,7,"InChI=1S/C31H30F3N5O3/c32-31(33,34)30-37-25(23-9-5-21(6-10-23)22-7-11-24(12-8-22)29(41)42)17-27(38-30)39-16-14-26(39)28(40)36-15-13-19-1-3-20(18-35)4-2-19/h1-6,9-10,17,22,24,26H,7-8,11-16H2,(H,36,40)(H,41,42)/t22-,24-,26-/m0/s1",DDAWTSCZLAACFR-GVUKDKGQSA-N,"c(""G-protein coupled bile acid receptor 1"", ""Transcriptional regulator ERG"", ""Phosphodiesterase 4D"", ""Bile acid receptor FXR"")",151306,GPBAR,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 G alpha (s) signalling events R-HSA-418555 GPCR ligand binding R-HSA-500792,cytoplasm GO:0005737 12524422 IDA plasma membrane GO:0005886 12419312 12524422 IDA plasma membrane GO:0005886 TAS integral component of membrane GO:0016021 IEA,G-protein coupled receptor signaling pathway IEA GO:0007186 cell surface bile acid receptor signaling pathway IC 12524422 GO:0038184 regulation of bicellular tight junction assembly IEA GO:2000810,bile acid receptor activity GO:0038181 IDA 12419312 12524422 G-protein coupled bile acid receptor activity GO:0038182 NAS 12419312,,CHEMBL CHEMBL569766,Q99527,G-protein coupled estrogen receptor 1,1.0,PRIMARY,NO,CC(=O)c1ccc2N[C@H]([C@H]3CC=C[C@H]3c2c1)c4cc5OCOc5cc4Br,3,18,"InChI=1S/C21H18BrNO3/c1-11(24)12-5-6-18-15(7-12)13-3-2-4-14(13)21(23-18)16-8-19-20(9-17(16)22)26-10-25-19/h2-3,5-9,13-14,21,23H,4,10H2,1H3/t13-,14+,21-/m1/s1",VHSVKVWHYFBIFJ-HKZYLEAXSA-N,"c(""G-protein coupled estrogen receptor 1"", ""Estrogen receptor alpha"", ""Estrogen receptor beta"", ""SK-BR-3"", ""MCF7"")",2852,GPER1,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,Golgi membrane GO:0000139 IEA intracellular GO:0005622 ISS nucleus 20551055 23285008 GO:0005634 IDA nuclear envelope 15705806 GO:0005635 IDA cytoplasm GO:0005737 ISS early endosome 21540189 GO:0005769 IDA endoplasmic reticulum 15705806 21540189 GO:0005783 IDA endoplasmic reticulum membrane GO:0005789 IEA Golgi apparatus 15705806 GO:0005794 IDA trans-Golgi network 21540189 GO:0005802 IDA cytosol GO:0005829 IEA plasma membrane 15539556 19931550 21149639 21427217 21540189 23674134 GO:0005886 IDA plasma membrane NOT 15705806 GO:0005886 IDA plasma membrane GO:0005886 TAS integral component of plasma membrane 8920907 GO:0005887 TAS postsynaptic density GO:0014069 ISS cell junction GO:0030054 IEA axon GO:0030424 ISS dendrite GO:0030425 ISS cytoplasmic vesicle membrane 21540189 GO:0030659 IDA mitochondrial membrane GO:0031966 ISS dendritic spine membrane GO:0032591 ISS presynaptic membrane GO:0042734 ISS dendritic shaft GO:0043198 ISS axon terminus GO:0043679 ISS dendritic spine head GO:0044327 ISS keratin filament 21149639 GO:0045095 IDA perinuclear region of cytoplasm 21540189 GO:0048471 IDA presynaptic active zone GO:0048786 ISS recycling endosome 21540189 GO:0055037 IDA,GO:0001934 positive regulation of protein phosphorylation 20551055 21427217 IDA GO:0001934 positive regulation of protein phosphorylation ISS GO:0001956 positive regulation of neurotransmitter secretion ISS GO:0002695 negative regulation of leukocyte activation 23285008 IDA GO:0006954 inflammatory response IEA GO:0007049 cell cycle IEA GO:0007186 G-protein coupled receptor signaling pathway 23840305 IMP GO:0007204 positive regulation of cytosolic calcium ion concentration ISS GO:0008284 positive regulation of cell proliferation 20551055 IMP GO:0008285 negative regulation of cell proliferation ISS GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway 15539556 IDA GO:0010628 positive regulation of gene expression 23840305 IMP GO:0010628 positive regulation of gene expression ISS GO:0010629 negative regulation of gene expression 23840305 IMP GO:0010629 negative regulation of gene expression ISS GO:0010948 negative regulation of cell cycle process 23840305 IMP GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling 15705806 IDA GO:0019228 neuronal action potential ISS GO:0030263 apoptotic chromosome condensation ISS GO:0030264 nuclear fragmentation involved in apoptotic nuclear change ISS GO:0030335 positive regulation of cell migration 20551055 IMP GO:0030518 intracellular steroid hormone receptor signaling pathway 15705806 IDA GO:0030819 positive regulation of cAMP biosynthetic process 15539556 21149639 IDA GO:0031959 mineralocorticoid receptor signaling pathway IEA GO:0032024 positive regulation of insulin secretion ISS GO:0032962 positive regulation of inositol trisphosphate biosynthetic process 15705806 IDA GO:0043065 positive regulation of apoptotic process ISS GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISS GO:0043401 steroid hormone mediated signaling pathway 19931550 IDA GO:0043410 positive regulation of MAPK cascade ISS GO:0045087 innate immune response IEA GO:0045599 negative regulation of fat cell differentiation ISS GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway 15705806 IDA GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway 15539556 IDA GO:0045909 positive regulation of vasodilation ISS GO:0045944 positive regulation of transcription from RNA polymerase II promoter 20551055 IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS GO:0050728 negative regulation of inflammatory response 23285008 IDA GO:0050769 positive regulation of neurogenesis ISS GO:0051053 negative regulation of DNA metabolic process ISS GO:0051055 negative regulation of lipid biosynthetic process ISS GO:0051281 positive regulation of release of sequestered calcium ion into cytosol 15705806 IDA GO:0051480 regulation of cytosolic calcium ion concentration ISS GO:0051898 negative regulation of protein kinase B signaling 23840305 IMP GO:0070373 negative regulation of ERK1 and ERK2 cascade 23840305 IMP GO:0070374 positive regulation of ERK1 and ERK2 cascade 20551055 21427217 IDA GO:0070374 positive regulation of ERK1 and ERK2 cascade ISS GO:0070474 positive regulation of uterine smooth muscle contraction 21427217 IDA GO:0071157 negative regulation of cell cycle arrest ISS GO:0071333 cellular response to glucose stimulus ISS GO:0071356 cellular response to tumor necrosis factor 23285008 IDA GO:0071375 cellular response to peptide hormone stimulus 21427217 IDA GO:0071389 cellular response to mineralocorticoid stimulus ISS GO:0071392 cellular response to estradiol stimulus 15539556 15705806 19931550 20551055 21149639 21427217 21540189 23285008 IDA GO:0090004 positive regulation of establishment of protein localization to plasma membrane 23674134 IDA GO:0090200 positive regulation of release of cytochrome c from mitochondria ISS GO:1904706 negative regulation of vascular smooth muscle cell proliferation 23840305 IMP GO:2000353 positive regulation of endothelial cell apoptotic process ISS GO:2000724 positive regulation of cardiac vascular smooth muscle cell differentiation 23840305 IMP GO:2001238 positive regulation of extrinsic apoptotic signaling pathway ISS,IDA 20551055 chromatin binding GO:0003682 IEA GO:0004930 G-protein coupled receptor activity IDA 15539556 15705806 steroid binding GO:0005496 IPI 20551055 21149639 23674134 protein binding GO:0005515 IEA GO:0008144 drug binding ISS GO:0017082 mineralocorticoid receptor activity IDA 15539556 15705806 estrogen receptor activity GO:0030284 IDA 19931550 steroid hormone binding GO:1990239,Estrogen signaling pathway - Homo sapiens (human) hsa04915,CHEMBL CHEMBL3311302,Q5NUL3,G-protein coupled receptor 120,1.0,PRIMARY,NO,Cc1ccc(cc1)S(=O)(=O)NC2c3ccccc3Oc4ccccc24,2,4,"InChI=1S/C20H17NO3S/c1-14-10-12-15(13-11-14)25(22,23)21-20-16-6-2-4-8-18(16)24-19-9-5-3-7-17(19)20/h2-13,20-21H,1H3",OZCQEUZTOAAWDK-UHFFFAOYSA-N,"c(""Free fatty acid receptor 1"", ""G-protein coupled receptor 120"")",338557,FFAR4,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Free fatty acid receptors R-HSA-444209 GPCR ligand binding R-HSA-500792,GO:0005886 plasma membrane ISS GO:0005887 integral component of plasma membrane IBA GO:0030139 endocytic vesicle IEA,G-protein coupled receptor signaling pathway GO:0007186 IEA regulation of glucose transport GO:0010827 ISS cellular response to hormone stimulus GO:0032870 NOT IBA negative regulation of apoptotic process GO:0043066 ISS fat cell differentiation GO:0045444 IEA hormone secretion GO:0046879 IBA negative regulation of cytokine secretion GO:0050710 ISS negative regulation of inflammatory response GO:0050728 ISS detection of chemical stimulus involved in sensory perception of taste GO:0050912 IEA positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS response to peptide GO:1901652 NOT IBA,IBA GO:0005504 fatty acid binding ISS GO:0005504 fatty acid binding IBA GO:0008527 taste receptor activity IBA GO:0042277 NOT peptide binding,,CHEMBL CHEMBL2392174,Q9HC97,G-protein coupled receptor 35,1.0,ORTHOGONAL,YES,COc1ccc(cc1)C(=O)Nc2cc(Br)cc3C(=O)C=C(Oc23)C(=O)O,2,10,"InChI=1S/C18H12BrNO6/c1-25-11-4-2-9(3-5-11)17(22)20-13-7-10(19)6-12-14(21)8-15(18(23)24)26-16(12)13/h2-8H,1H3,(H,20,22)(H,23,24)",TZKQFDIFVZAYER-UHFFFAOYSA-N,"c(""G-protein coupled receptor 55"", ""G-protein coupled receptor 35"", ""Unchecked"")",2859,GPR35,,integral component of plasma membrane IDA 16754668 GO:0005887,IDA 16754668 G-protein coupled receptor signaling pathway GO:0007186,G-protein coupled receptor activity GO:0004930 16754668 IDA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL177880,Q9HC97,G-protein coupled receptor 35,1.0,PRIMARY,YES,OC(=O)c1cc2ccccc2c(Cc3c(O)c(cc4ccccc34)C(=O)O)c1O,2,77,"InChI=1S/C23H16O6/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29/h1-10,24-25H,11H2,(H,26,27)(H,28,29)",WLJNZVDCPSBLRP-UHFFFAOYSA-N,"c(""Flap endonuclease 1"", ""DNA polymerase iota"", ""HepG2"", ""DNA polymerase kappa"", ""MDA-N"", ""SN12C"", ""NCI-H23"", ""ACHN"", ""UO-31"", ""HL-60"", ""HOP-92"", ""DU-145"", ""Malme-3M"", ""SK-MEL-5"", ""K562"", ""OVCAR-3"", ""A498"", ""MOLT-4"", ""HOP-62"", ""U-251"", ""NCI/ADR-RES"", ""OVCAR-8"", ""OVCAR-5"", ""SNB-19"", ""SR"", ""MDA-MB-231"", ""TK-10"", ""SW-620"", ""NCI-H522"", ""M14"", ""KM12"", ""NCI-H322M"", ""RPMI-8226"", ""OVCAR-4"", ""BT-549"", ""LOX IMVI"", ""SK-MEL-2"", ""A549"", ""HCC 2998"", ""HCT-15"", ""SF-268"", ""HCT-116"", ""EKVX"", ""PC-3"", ""T47D"", ""NCI-H460"", ""UACC-62"", ""MDA-MB-435"", ""CAKI-1"", ""SF-295"", ""IGROV-1"", ""Hs-578T"", ""786-0"", ""UACC-257"", ""CCRF-CEM"", ""NCI-H226"", ""HT-29"", ""SK-MEL-28"", ""RXF 393"", ""Glutaminase kidney isoform, mitochondrial"", ""Unchecked"", ""DNA polymerase beta"", ""G-protein coupled receptor 35"")",2859,GPR35,,integral component of plasma membrane IDA 16754668 GO:0005887,IDA 16754668 G-protein coupled receptor signaling pathway GO:0007186,G-protein coupled receptor activity GO:0004930 16754668 IDA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL3092413,O43194,G-protein coupled receptor 39,1.0,ORTHOGONAL,YES,Clc1ccc2nc(CN3CCN(CC3)c4ccc(cn4)C#N)cn2c1,3,7,"InChI=1S/C18H17ClN6/c19-15-2-4-18-22-16(13-25(18)11-15)12-23-5-7-24(8-6-23)17-3-1-14(9-20)10-21-17/h1-4,10-11,13H,5-8,12H2",UGDJVSURAKMIPU-UHFFFAOYSA-N,"c(""G-protein coupled receptor 39"", ""Phosphodiesterase 3B"", ""Phosphodiesterase 3A"")",2863,GPR39,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-500792 GPCR ligand binding,GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 9441746 TAS,IEA GO:0007186 G-protein coupled receptor signaling pathway,G-protein coupled receptor activity GO:0004930 IEA metal ion binding GO:0046872 IEA,,CHEMBL CHEMBL3342358,O43194,G-protein coupled receptor 39,1.0,PRIMARY,YES,CNc1nc(NCc2ccc(NS(=O)(=O)C)cc2Cl)cc(n1)c3ccccn3,3,9,"InChI=1S/C18H19ClN6O2S/c1-20-18-23-16(15-5-3-4-8-21-15)10-17(24-18)22-11-12-6-7-13(9-14(12)19)25-28(2,26)27/h3-10,25H,11H2,1-2H3,(H2,20,22,23,24)",DRSZMILOMUPIBJ-UHFFFAOYSA-N,"c(""G-protein coupled receptor 39"", ""Unchecked"", ""Ghrelin receptor"", ""Neurotensin receptor 1"")",2863,GPR39,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-500792 GPCR ligand binding,GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 9441746 TAS,IEA GO:0007186 G-protein coupled receptor signaling pathway,G-protein coupled receptor activity GO:0004930 IEA metal ion binding GO:0046872 IEA,,CHEMBL CHEMBL217053,Q9Y5Y4,G protein-coupled receptor 44,1.0,PRIMARY,NO,OC(=O)COc1ccc(Br)cc1C(=O)c2cnn(c2)c3ccccc3,36,50,"InChI=1S/C18H13BrN2O4/c19-13-6-7-16(25-11-17(22)23)15(8-13)18(24)12-9-20-21(10-12)14-4-2-1-3-5-14/h1-10H,11H2,(H,22,23)",DMFOOUGJUFPBOG-UHFFFAOYSA-N,"c(""G protein-coupled receptor 44"", ""Phospholipase A2 group 1B"", ""Cyclooxygenase-1"", ""Cyclooxygenase-2"", ""Arachidonate 12-lipoxygenase"", ""Arachidonate 15-lipoxygenase"", ""Prostanoid DP receptor"", ""Adenosine A1 receptor"", ""Adenosine A2a receptor"", ""Adrenergic receptor alpha-1"", ""Adrenergic receptor alpha-2"", ""Beta-1 adrenergic receptor"", ""Type-1 angiotensin II receptor"", ""Angiotensin II type 2 (AT-2) receptor"", ""GABA-A receptor; anion channel"", ""Bradykinin B2 receptor"", ""Cholecystokinin A receptor"", ""C5a anaphylatoxin chemotactic receptor"", ""G-protein coupled receptor ChemR23"", ""Dopamine D1 receptor"", ""Dopamine D2 receptor"", ""Endothelin receptor ET-A"", ""Formyl peptide receptor 1"", ""Glutamate [NMDA] receptor"", ""Gastric inhibitory polypeptide receptor"", ""Histamine H1 receptor"", ""Histamine H2 receptor"", ""Cysteinyl leukotriene receptor 1"", ""Melanin-concentrating hormone receptor 1"", ""Melanocortin receptor 4"", ""Muscarinic acetylcholine receptor"", ""Neurokinin 1 receptor"", ""Unchecked"", ""Opioid receptors; mu/kappa/delta"", ""Nociceptin receptor"", ""Platelet activating factor receptor"", ""Thromboxane A2 receptor"", ""Serotonin (5-HT) receptor"", ""Sigma opioid receptor"", ""Somatostatin receptor"", ""Glucocorticoid receptor"", ""Vasopressin V1a receptor"", ""Norepinephrine transporter"", ""Dopamine transporter"", ""Serotonin transporter"")",11251,PD2R2,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 Eicosanoid ligand-binding receptors R-HSA-391903 Prostanoid ligand receptors R-HSA-391908 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,intracellular GO:0005622 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 TAS 10036181 neuron projection GO:0043005 IBA,"chemotaxis GO:0006935 11208866 IDA immune response GO:0006955 9973380 TAS G-protein coupled receptor signaling pathway GO:0007186 11208866 IDA G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 IBA adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 IEA neuropeptide signaling pathway GO:0007218 IBA chemical synaptic transmission GO:0007268 IBA calcium-mediated signaling GO:0019722 11208866 IDA positive regulation of G-protein coupled receptor protein signaling pathway GO:0045745 IEA negative regulation of male germ cell proliferation GO:2000255 IEA",GO:0001785 prostaglandin J receptor activity IEA 11208866 GO:0004930 G-protein coupled receptor activity IDA 11208866 GO:0004956 prostaglandin D receptor activity IDA GO:0004958 prostaglandin F receptor activity IEA GO:0042923 neuropeptide binding IBA,,CHEMBL CHEMBL505,P35367,Histamine H1 receptor,1.0,PRIMARY,NO,CN(C)CCC(c1ccc(Cl)cc1)c2ccccn2,6,26,"InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3",SOYKEARSMXGVTM-UHFFFAOYSA-N,"c(""Unchecked"", ""Sodium channel alpha subunits; brain (Types I, II, III)"", ""Platelet activating factor receptor"", ""Homo sapiens"", ""Histamine H1 receptor"", ""Lethal(3)malignant brain tumor-like protein 4"", ""Lethal(3)malignant brain tumor-like protein 3"", ""Lethal(3)malignant brain tumor-like protein 1"", ""MBT domain-containing protein 1"", ""Ataxin-2"", ""Flap endonuclease 1"", ""SH-SY5Y"", ""P-glycoprotein 1"", ""Cerebroside-sulfatase"")",3269,HRH1,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375280 Amine ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-390650 Histamine receptors R-HSA-416476 G alpha (q) signalling events R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,IDA GO:0005654 nucleoplasm IDA GO:0005737 cytoplasm IDA GO:0005886 plasma membrane TAS GO:0005886 plasma membrane ISS GO:0005887 integral component of plasma membrane,inflammatory response 10818238 GO:0006954 TAS G-protein coupled receptor signaling pathway GO:0007186 ISS phospholipase C-activating G-protein coupled receptor signaling pathway 8280179 GO:0007200 TAS memory GO:0007613 IEA visual learning GO:0008542 IEA regulation of vasoconstriction GO:0019229 IBA positive regulation of inositol trisphosphate biosynthetic process GO:0032962 ISS regulation of vascular permeability GO:0043114 IEA positive regulation of vasoconstriction GO:0045907 IEA inositol phosphate-mediated signaling GO:0048016 ISS regulation of synaptic plasticity GO:0048167 IEA eosinophil chemotaxis GO:0048245 IEA modulation of synaptic transmission GO:0050804 IBA cellular response to histamine GO:0071420 ISS,G-protein coupled receptor activity TAS 7925364 GO:0004930 histamine receptor activity ISS GO:0004969,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human),CHEMBL CHEMBL269646,P25021,Histamine H2 receptor,1.0,PRIMARY,NO,C\N=C(\NCCSCc1csc(N=C(N)N)n1)/NC#N,2,11,"InChI=1S/C10H16N8S2/c1-14-9(16-6-11)15-2-3-19-4-7-5-20-10(17-7)18-8(12)13/h5H,2-4H2,1H3,(H2,14,15,16)(H4,12,13,17,18)",YDDXVAXDYKBWDX-UHFFFAOYSA-N,"c(""Unchecked"", ""Microtubule-associated protein tau"", ""Regulator of G-protein signaling 4"", ""Histamine H2 receptor"")",3274,HRH2,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Amine ligand-binding receptors R-HSA-375280 GPCR downstream signaling R-HSA-388396 Histamine receptors R-HSA-390650 G alpha (s) signalling events R-HSA-418555 GPCR ligand binding R-HSA-500792,TAS GO:0005886 plasma membrane 1714721 TAS GO:0005887 integral component of plasma membrane,"GO:0001697 histamine-induced gastric acid secretion IEA GO:0001698 gastrin-induced gastric acid secretion IEA GO:0003382 epithelial cell morphogenesis IEA 9725260 GO:0006955 immune response TAS 9725260 GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS GO:0007613 memory IEA GO:0008542 visual learning IEA GO:0045907 positive regulation of vasoconstriction IEA GO:0048167 regulation of synaptic plasticity IEA GO:0048565 digestive tract development IEA GO:0048732 gland development IEA GO:1901998 toxin transport IEA",GO:0004969 histamine receptor activity IEA,Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Gastric acid secretion - Homo sapiens (human) hsa04971,CHEMBL CHEMBL555146,Q9Y5N1,Histamine H3 receptor,1.0,ORTHOGONAL,NO,C[C@@H]1CCCN1CCc2oc3ccc(cc3c2)C(=O)c4ccc(F)cc4,38,42,"InChI=1S/C22H22FNO2/c1-15-3-2-11-24(15)12-10-20-14-18-13-17(6-9-21(18)26-20)22(25)16-4-7-19(23)8-5-16/h4-9,13-15H,2-3,10-12H2,1H3/t15-/m1/s1",VGSYEFOBFMUWGO-OAHLLOKOSA-N,"c(""Histamine H3 receptor"", ""Histamine H1 receptor"", ""Histamine H2 receptor"", ""Histamine H4 receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Serotonin 1d (5-HT1d) receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 2b (5-HT2b) receptor"", ""Dopamine transporter"", ""Muscarinic acetylcholine receptor M1"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M4"", ""Muscarinic acetylcholine receptor M5"", ""Serotonin 1e (5-HT1e) receptor"", ""Serotonin 2c (5-HT2c) receptor"", ""Serotonin 3a (5-HT3a) receptor"", ""Serotonin 5a (5-HT5a) receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Serotonin 7 (5-HT7) receptor"", ""Alpha-1a adrenergic receptor"", ""Alpha-1b adrenergic receptor"", ""Alpha-1d adrenergic receptor"", ""Alpha-2a adrenergic receptor"", ""Alpha-2b adrenergic receptor"", ""Alpha-2c adrenergic receptor"", ""Beta-1 adrenergic receptor"", ""Beta-2 adrenergic receptor"", ""Beta-3 adrenergic receptor"", ""Dopamine D1 receptor"", ""Dopamine D2 receptor"", ""Dopamine D3 receptor"", ""Dopamine D4 receptor"", ""Dopamine D5 receptor"", ""Sigma opioid receptor"", ""Unchecked"", ""Serotonin transporter"", ""Norepinephrine transporter"")",11255,HRH3,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Amine ligand-binding receptors R-HSA-375280 GPCR downstream signaling R-HSA-388396 Histamine receptors R-HSA-390650 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 10347254 TAS presynapse GO:0098793 IEA,"G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 10347254 GO:0007187 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway IBA GO:0007197 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway IBA GO:0007207 neurotransmitter secretion TAS 10347254 GO:0007269 synaptic transmission, cholinergic IBA GO:0007271 negative regulation of glutamate secretion IBA GO:0014050 regulation of norepinephrine secretion IBA GO:0014061 negative regulation of serotonin secretion IBA GO:0014063 cognition IBA GO:0050890",histamine receptor activity GO:0004969 IEA G-protein coupled acetylcholine receptor activity GO:0016907 IBA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL2031737,Q9Y5N1,Histamine H3 receptor,1.0,PRIMARY,NO,C[C@@H]1CCCN1CCc2oc3ccc(cc3c2)C(=O)c4ccc(cc4)[N+](=O)[O-],38,77,"InChI=1S/C22H22N2O4/c1-15-3-2-11-23(15)12-10-20-14-18-13-17(6-9-21(18)28-20)22(25)16-4-7-19(8-5-16)24(26)27/h4-9,13-15H,2-3,10-12H2,1H3/t15-/m1/s1",GPZMWOXSIRVXQW-OAHLLOKOSA-N,"c(""Histamine H1 receptor"", ""Histamine H2 receptor"", ""Histamine H3 receptor"", ""Histamine H4 receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Serotonin 1d (5-HT1d) receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 2b (5-HT2b) receptor"", ""Dopamine transporter"", ""Muscarinic acetylcholine receptor M1"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M4"", ""Muscarinic acetylcholine receptor M5"", ""Serotonin 1e (5-HT1e) receptor"", ""Serotonin 2c (5-HT2c) receptor"", ""Serotonin 3a (5-HT3a) receptor"", ""Serotonin 5a (5-HT5a) receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Serotonin 7 (5-HT7) receptor"", ""Alpha-1a adrenergic receptor"", ""Alpha-1b adrenergic receptor"", ""Alpha-1d adrenergic receptor"", ""Alpha-2a adrenergic receptor"", ""Alpha-2b adrenergic receptor"", ""Alpha-2c adrenergic receptor"", ""Beta-1 adrenergic receptor"", ""Beta-2 adrenergic receptor"", ""Beta-3 adrenergic receptor"", ""Dopamine D1 receptor"", ""Dopamine D2 receptor"", ""Dopamine D3 receptor"", ""Dopamine D4 receptor"", ""Dopamine D5 receptor"", ""Sigma opioid receptor"", ""Unchecked"", ""Serotonin transporter"", ""Norepinephrine transporter"")",11255,HRH3,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Amine ligand-binding receptors R-HSA-375280 GPCR downstream signaling R-HSA-388396 Histamine receptors R-HSA-390650 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 10347254 TAS presynapse GO:0098793 IEA,"G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 10347254 GO:0007187 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway IBA GO:0007197 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway IBA GO:0007207 neurotransmitter secretion TAS 10347254 GO:0007269 synaptic transmission, cholinergic IBA GO:0007271 negative regulation of glutamate secretion IBA GO:0014050 regulation of norepinephrine secretion IBA GO:0014061 negative regulation of serotonin secretion IBA GO:0014063 cognition IBA GO:0050890",histamine receptor activity GO:0004969 IEA G-protein coupled acetylcholine receptor activity GO:0016907 IBA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL1836142,Q13547,Histone deacetylase 1,1.0,PRIMARY,NO,CC[C@H](C)[C@H]1NC(=O)[C@H]2CSSCC\C=C\[C@H](CC(=O)N[C@H](CCSC)C(=O)N2)OC(=O)C[C@@H]1O,6,50,"InChI=1S/C23H37N3O6S3/c1-4-14(2)21-18(27)12-20(29)32-15-7-5-6-9-34-35-13-17(23(31)26-21)25-22(30)16(8-10-33-3)24-19(28)11-15/h5,7,14-18,21,27H,4,6,8-13H2,1-3H3,(H,24,28)(H,25,30)(H,26,31)/b7-5+/t14-,15+,16+,17+,18-,21+/m0/s1",VJXBYUITQBTTQM-DSRNDQRRSA-N,"c(""Unchecked"", ""Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2)"", ""Histone deacetylase 4"", ""Histone deacetylase 6"", ""Histone deacetylase 7"", ""Histone deacetylase 8"", ""Histone deacetylase 9"", ""HCT-15"", ""PC-3"", ""ACHN"", ""U251"", ""SF-268"", ""KM12"", ""NCI-H23"", ""DU-145"", ""Histone deacetylase 1"", ""OVCAR-3"", ""MCF7"", ""NCI-H226"", ""HCC 2998"", ""MDA-MB-231"", ""LOX IMVI"", ""SF-295"", ""SK-OV-3"", ""SNB-75"", ""St-4"")",3065,HDAC1,"R-HSA-109582 Hemostasis R-HSA-1538133 G0 and Early G1 R-HSA-157118 Signaling by NOTCH R-HSA-162582 Signal Transduction R-HSA-1640170 Cell Cycle R-HSA-1643685 Disease R-HSA-166520 Signalling by NGF R-HSA-170834 Signaling by TGF-beta Receptor Complex R-HSA-193670 p75NTR negatively regulates cell cycle via SC1 R-HSA-193704 p75 NTR receptor-mediated signalling R-HSA-195253 Degradation of beta-catenin by the destruction complex R-HSA-195721 Signaling by Wnt R-HSA-1980143 Signaling by NOTCH1 R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-201722 formation of the beta-catenin:TCF transactivating complex R-HSA-212165 Epigenetic regulation of gene expression R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-212436 Generic Transcription Pathway R-HSA-2173793 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603 Signaling by NOTCH1 in Cancer R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-3214815 HDACs deacetylate histones R-HSA-3247509 Chromatin modifying enzymes R-HSA-427413 NoRC negatively regulates rRNA expression R-HSA-453279 Mitotic G1-G1/S phases R-HSA-4641265 repression of WNT target genes R-HSA-4839726 Chromatin organization R-HSA-504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-5250941 Negative epigenetic regulation of rRNA expression R-HSA-5663202 Diseases of signal transduction R-HSA-69278 Cell Cycle, Mitotic R-HSA-73762 RNA Polymerase I Transcription Initiation R-HSA-73854 RNA Polymerase I Promoter Clearance R-HSA-73864 RNA Polymerase I Transcription R-HSA-74159 Transcription R-HSA-74160 Gene Expression R-HSA-983231 Factors involved in megakaryocyte development and platelet production",histone deacetylase complex 12711221 GO:0000118 TAS chromatin 16731528 GO:0000785 IDA nuclear chromatin 16217013 22926524 GO:0000790 IDA nucleus 10846170 18347167 18936100 GO:0005634 IDA nucleoplasm 22720776 22926524 GO:0005654 IDA nucleoplasm GO:0005654 TAS cytoplasm 12711221 GO:0005737 TAS cytosol 18326024 GO:0005829 IDA Sin3 complex 17827154 GO:0016580 IDA NuRD complex 17827154 19644445 GO:0016581 IDA protein complex 16217013 GO:0043234 IDA,"GO:0000122 negative regulation of transcription from RNA polymerase II promoter 18854353 IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter 18936100 IGI GO:0000122 negative regulation of transcription from RNA polymerase II promoter 18850004 IMP GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS GO:0006338 chromatin remodeling 16762839 17827154 IC GO:0006351 transcription, DNA-templated IEA GO:0006476 protein deacetylation 17172643 IDA GO:0007596 blood coagulation TAS GO:0008284 positive regulation of cell proliferation 18347167 IMP GO:0009913 epidermal cell differentiation ISS GO:0010629 negative regulation of gene expression 16581785 IMP GO:0010832 negative regulation of myotube differentiation NOT 10983972 IMP GO:0010870 positive regulation of receptor biosynthetic process 18316616 IMP GO:0016032 viral process IEA GO:0016568 chromatin modification 12711221 TAS GO:0016575 histone deacetylation 19182791 IMP GO:0032922 circadian regulation of gene expression ISS GO:0042475 odontogenesis of dentin-containing tooth ISS GO:0042733 embryonic digit morphogenesis ISS GO:0043044 ATP-dependent chromatin remodeling 16217013 IDA GO:0043066 negative regulation of apoptotic process ISS GO:0043922 negative regulation by host of viral transcription 16540471 IMP GO:0045892 negative regulation of transcription, DNA-templated 18974119 IMP GO:0045892 negative regulation of transcription, DNA-templated ISS GO:0045893 positive regulation of transcription, DNA-templated 16762839 IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter 16762839 IDA GO:0060766 negative regulation of androgen receptor signaling pathway 15919722 IDA GO:0060789 hair follicle placode formation ISS GO:0061029 eyelid development in camera-type eye ISS GO:0061198 fungiform papilla formation ISS GO:0070932 histone H3 deacetylation 12590135 IDA GO:0070933 histone H4 deacetylation 12590135 IDA GO:0090090 negative regulation of canonical Wnt signaling pathway 18936100 IGI GO:1901796 regulation of signal transduction by p53 class mediator TAS GO:1904837 beta-catenin-TCF complex assembly TAS","ISS GO:0000976 transcription regulatory region sequence-specific DNA binding IDA contributes_to 16217013 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA contributes_to 16217013 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 IDA 18974119 core promoter binding GO:0001047 IPI 18936100 RNA polymerase II transcription factor binding GO:0001085 IPI 22926524 RNA polymerase II repressing transcription factor binding GO:0001103 IDA 15919722 RNA polymerase II transcription corepressor activity GO:0001106 TAS 8646880 transcription factor activity, sequence-specific DNA binding GO:0003700 IDA 16762839 histone deacetylase activity GO:0004407 IMP 17996965 19182791 histone deacetylase activity GO:0004407 TAS 12711221 histone deacetylase activity GO:0004407 IPI 9150135 10220385 10779361 10846170 10898795 11006275 11013263 11259576 11553631 11559788 11641274 11739383 11863372 11931769 12176973 12202768 12482978 12529400 12670868 12711603 12730668 14752048 15016378 15140878 15298701 15316101 15361834 15919722 15970276 16287849 16291753 16306601 16511565 16540471 16766265 16919237 16959611 16964284 17000776 17172643 17245431 17318229 17636019 17704056 17872950 17996965 18093978 18451879 18722353 18854353 18936100 19049980 19081374 19182791 19343227 19497860 19505873 19703393 20075864 20127688 20363964 20562920 20693977 21030595 21258344 21549307 21983900 22113938 22416134 22483618 22720776 23752268 25241761 25314079 26028330 26496610 protein binding GO:0005515 IPI 15509593 16569215 18850004 18974119 transcription factor binding GO:0008134 TAS 12711221 transcription factor binding GO:0008134 ISS GO:0019213 deacetylase activity IPI 11062478 11136718 11641274 enzyme binding GO:0019899 IDA contributes_to 16217013 nucleosomal DNA binding GO:0031492 IEA GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) IDA 17172643 protein deacetylase activity GO:0033558 IMP 19182791 protein deacetylase activity GO:0033558 IPI 20590529 activating transcription factor binding GO:0033613 IPI 12590135 histone deacetylase binding GO:0042826 IDA 16731528 transcription regulatory region DNA binding GO:0044212 IDA 17150957 protein N-terminus binding GO:0047485 IPI 17785205 NF-kappaB binding GO:0051059 IPI 16731528 repressing transcription factor binding GO:0070491","Cell cycle - Homo sapiens (human) hsa04110 Notch signaling pathway - Homo sapiens (human) hsa04330 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04919 Huntington,s disease - Homo sapiens (human) hsa05016 Amphetamine addiction - Homo sapiens (human) hsa05031 Alcoholism - Homo sapiens (human) hsa05034 Epstein-Barr virus infection - Homo sapiens (human) hsa05169 Pathways in cancer - Homo sapiens (human) hsa05200 Transcriptional misregulation in cancer - Homo sapiens (human) hsa05202 Viral carcinogenesis - Homo sapiens (human) hsa05203 MicroRNAs in cancer - Homo sapiens (human) hsa05206 Chronic myeloid leukemia - Homo sapiens (human) hsa05220",CHEMBL CHEMBL2431901,Q9UBN7,Histone deacetylase 6,1.0,PRIMARY,NO,Cn1cccc1C(=O)N2CCc3cc(ccc3C2)C(=O)NO,13,30,"InChI=1S/C16H17N3O3/c1-18-7-2-3-14(18)16(21)19-8-6-11-9-12(15(20)17-22)4-5-13(11)10-19/h2-5,7,9,22H,6,8,10H2,1H3,(H,17,20)",NNQAQGDSGCGFER-UHFFFAOYSA-N,"c(""Unchecked"", ""Histone deacetylase 6"", ""Histone deacetylase 3"", ""Histone deacetylase 1"", ""Histone deacetylase 8"", ""Histone deacetylase 11"", ""Histone deacetylase 10"", ""Histone deacetylase 7"", ""Histone deacetylase 5"", ""Histone deacetylase 4"", ""Histone deacetylase 2"", ""Matrix metalloproteinase 17"", ""Matrix metalloproteinase 9"", ""Matrix metalloproteinase-2"")",10013,HDAC6,Signaling by NOTCH R-HSA-157118 Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Organelle biogenesis and maintenance R-HSA-1852241 Signaling by NOTCH1 R-HSA-1980143 NOTCH1 Intracellular Domain Regulates Transcription R-HSA-2122947 Cellular responses to stress R-HSA-2262752 Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644602 Signaling by NOTCH1 in Cancer R-HSA-2644603 Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2644606 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2894858 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2894862 HSF1 activation R-HSA-3371511 Cellular response to heat stress R-HSA-3371556 Assembly of the primary cilium R-HSA-5617833 Diseases of signal transduction R-HSA-5663202,11948178 GO:0000118 histone deacetylase complex IDA GO:0005634 nucleus ISS 11861901 GO:0005737 cytoplasm ISS 25548531 GO:0005771 multivesicular body TAS GO:0005829 cytosol ISS GO:0005829 cytosol TAS 12620231 GO:0005874 microtubule IDA 19228685 GO:0005875 microtubule associated complex IDA GO:0005881 cytoplasmic microtubule IEA 18356165 GO:0005901 caveola IDA 16192271 GO:0016234 inclusion body IDA 14675537 GO:0016235 aggresome IDA 14675537 GO:0030286 dynein complex IDA colocalizes_with GO:0030424 axon ISS GO:0030425 dendrite ISS 12024216 GO:0031252 cell leading edge IDA GO:0043204 perikaryon ISS 12024216 GO:0048471 perinuclear region of cytoplasm IDA,"protein polyubiquitination GO:0000209 IEA transcription, DNA-templated GO:0006351 IEA protein deacetylation GO:0006476 IMP 15916966 misfolded or incompletely synthesized protein catabolic process GO:0006515 IMP 14675537 intracellular protein transport GO:0006886 IMP 16192271 organelle organization GO:0006996 TAS negative regulation of microtubule depolymerization GO:0007026 IEA response to toxic substance GO:0009636 IMP 19158084 positive regulation of signal transduction GO:0009967 IMP 19158084 response to organic substance GO:0010033 IMP 19158084 regulation of receptor activity GO:0010469 IMP 19158084 regulation of autophagy GO:0010506 TAS 25548531 positive regulation of epithelial cell migration GO:0010634 IMP 12024216 negative regulation of hydrogen peroxide metabolic process GO:0010727 IC 18606987 positive regulation of receptor biosynthetic process GO:0010870 IMP 15916966 18316616 macroautophagy GO:0016236 IMP 16192271 histone deacetylation GO:0016575 IDA 10220385 histone deacetylation GO:0016575 ISS 11861901 regulation of protein stability GO:0031647 IMP 23580651 lysosome localization GO:0032418 IMP 16192271 peptidyl-lysine deacetylation GO:0034983 IMP 18356165 18606987 cellular response to topologically incorrect protein GO:0035967 IMP 16192271 regulation of gene expression, epigenetic GO:0040029 IMP 24413532 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 IEA protein complex disassembly GO:0043241 IEA negative regulation of protein complex disassembly GO:0043242 IMP 15916966 regulation of fat cell differentiation GO:0045598 IEA negative regulation of proteolysis GO:0045861 IMP 18356165 negative regulation of transcription, DNA-templated GO:0045892 ISS 11861901 negative regulation of oxidoreductase activity GO:0051354 IC 18606987 mitochondrion localization GO:0051646 IEA response to misfolded protein GO:0051788 IMP 14675537 regulation of microtubule-based movement GO:0060632 IC 19228685 regulation of androgen receptor signaling pathway GO:0060765 TAS 18852123 regulation of establishment of protein localization GO:0070201 IEA cellular response to hydrogen peroxide GO:0070301 IMP 18606987 aggresome assembly GO:0070842 IMP 14675537 polyubiquitinated misfolded protein transport GO:0070845 IMP 14675537 Hsp90 deacetylation GO:0070846 IMP 19158084 response to growth factor GO:0070848 IMP 18356165 histone H3 deacetylation GO:0070932 IEA cellular response to misfolded protein GO:0071218 IEA positive regulation of chaperone-mediated protein complex assembly GO:0090035 IMP 19158084 tubulin deacetylation GO:0090042 IDA 19228685 tubulin deacetylation GO:0090042 ISS mitophagy in response to mitochondrial depolarization GO:0098779 IGI 20457763 positive regulation of hydrogen peroxide-mediated programmed cell death GO:1901300 IDA 18606987 regulation of mitophagy GO:1903146 TAS 25548531",24413532 IDA GO:0001047 core promoter binding IEA GO:0003779 actin binding 10220385 IDA GO:0004407 histone deacetylase activity 23322205 IMP GO:0004407 histone deacetylase activity 16919237 17872950 19033385 19081074 19167333 19893491 20029029 21532619 21847094 21952047 22193721 22645275 24658140 24687993 IPI GO:0005515 protein binding 18356165 IPI GO:0008013 beta-catenin binding 19228685 IDA GO:0008017 microtubule binding ISS GO:0008017 microtubule binding IEA GO:0008270 zinc ion binding 11861901 ISS GO:0019899 enzyme binding 14675537 IDA GO:0031593 polyubiquitin binding 21753002 IPI GO:0031625 ubiquitin protein ligase binding IEA GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) 12620231 IPI GO:0042826 histone deacetylase binding 12620231 19228685 IDA GO:0042903 tubulin deacetylase activity ISS GO:0042903 tubulin deacetylase activity TAS GO:0042903 tubulin deacetylase activity 19228685 IDA GO:0043014 alpha-tubulin binding 18636984 IDA GO:0048156 tau protein binding IEA GO:0048487 beta-tubulin binding 17785525 EXP GO:0051787 misfolded protein binding 15916966 IDA GO:0051879 Hsp90 protein binding 14675537 IDA GO:0070840 dynein complex binding,Alcoholism - Homo sapiens (human) hsa05034 Viral carcinogenesis - Homo sapiens (human) hsa05203,CHEMBL CHEMBL2171169,Q8TEK3,"Histone-lysine N-methyltransferase, H3 lysine-79 specific",1.0,PRIMARY,NO,CC(C)N(CCCNC(=O)Nc1ccc(cc1)C(C)(C)C)C[C@H]2O[C@H]([C@H](O)[C@@H]2O)n3cnc4c(N)ncnc34,4,28,"InChI=1S/C27H40N8O4/c1-16(2)34(12-6-11-29-26(38)33-18-9-7-17(8-10-18)27(3,4)5)13-19-21(36)22(37)25(39-19)35-15-32-20-23(28)30-14-31-24(20)35/h7-10,14-16,19,21-22,25,36-37H,6,11-13H2,1-5H3,(H2,28,30,31)(H2,29,33,38)/t19-,21-,22-,25-/m1/s1",MTLMDZJUGDUTCP-PTGPVQHPSA-N,"c(""Histone-lysine N-methyltransferase, H3 lysine-79 specific"", ""Unchecked"", ""THP-1"", ""MV4-11"", ""Histone-lysine N-methyltransferase SUV39H1"", ""Histone-arginine methyltransferase CARM1"", ""Protein-arginine N-methyltransferase 1"", ""MOLM-13"")",84444,DOT1L,R-HSA-3214841 PKMTs methylate histone lysines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization,GO:0005654 nucleoplasm IDA GO:0005654 nucleoplasm TAS,GO:0006342 chromatin silencing IEA GO:0032200 telomere organization 17675446 TAS GO:0034729 histone H3-K79 methylation IEA GO:0046425 regulation of JAK-STAT cascade 22002246 IDA GO:0051726 regulation of cell cycle IEA GO:2000677 regulation of transcription regulatory region DNA binding 22002246 IMP,IEA GO:0003677 DNA binding IPI 20153263 20203130 26496610 protein binding GO:0005515 IDA 17707234 histone-lysine N-methyltransferase activity GO:0018024 TAS GO:0018024 histone-lysine N-methyltransferase activity IEA GO:0031151 histone methyltransferase activity (H3-K79 specific),Lysine degradation - Homo sapiens (human) hsa00310 Transcriptional misregulation in cancer - Homo sapiens (human) hsa05202,CHEMBL CHEMBL1829304,Q96KQ7,"Histone-lysine N-methyltransferase, H3 lysine-9 specific 3",1.0,PRIMARY,NO,COc1cc2c(NC3CCN(CC3)C4CCCCC4)nc(nc2cc1OCCCN5CCCCC5)N6CCCN(CC6)C(C)C,6,19,"InChI=1S/C36H59N7O2/c1-28(2)41-19-10-20-43(24-23-41)36-38-32-27-34(45-25-11-18-40-16-8-5-9-17-40)33(44-3)26-31(32)35(39-36)37-29-14-21-42(22-15-29)30-12-6-4-7-13-30/h26-30H,4-25H2,1-3H3,(H,37,38,39)",OUKWLRHRXOPODD-UHFFFAOYSA-N,"c(""Histone-lysine N-methyltransferase, H3 lysine-9 specific 3"", ""MDA-MB-231"", ""Unchecked"", ""PC-3"", ""CWR22R"", ""HCT-116"", ""Histone-lysine N-methyltransferase, H3 lysine-9 specific 5"", ""Protein arginine N-methyltransferase 3"", ""Histone-lysine N-methyltransferase SETD7"", ""Histone-lysine N-methyltransferase SUV39H2"", ""N-lysine methyltransferase SETD8"")",10919,EHMT2,"R-HSA-2262752 Cellular responses to stress R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559583 Cellular Senescence R-HSA-3214841 PKMTs methylate histone lysines R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization R-HSA-504046 RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription R-HSA-73762 RNA Polymerase I Transcription Initiation R-HSA-73854 RNA Polymerase I Promoter Clearance R-HSA-73864 RNA Polymerase I Transcription R-HSA-74159 Transcription R-HSA-74160 Gene Expression",19144645 GO:0000790 nuclear chromatin IDA 19144645 GO:0005634 nucleus IDA GO:0005634 nucleus ISS GO:0005654 nucleoplasm IDA GO:0005654 nucleoplasm TAS,GO:0000122 negative regulation of transcription from RNA polymerase II promoter 19144645 IDA GO:0006275 regulation of DNA replication 22387026 IMP GO:0006306 DNA methylation ISS GO:0009267 cellular response to starvation 23918802 IDA GO:0016571 histone methylation 22387026 IMP GO:0018027 peptidyl-lysine dimethylation 20118233 IDA GO:0034968 histone lysine methylation 19144645 IDA GO:0051567 histone H3-K9 methylation IEA GO:0070734 histone H3-K27 methylation IEA GO:1901796 regulation of signal transduction by p53 class mediator TAS,IPI 20118233 p53 binding GO:0002039 IPI 16189514 16287849 17636019 18451879 19061646 21549307 23752268 24492005 26028330 protein binding GO:0005515 IEA GO:0008270 zinc ion binding IDA 20118233 protein-lysine N-methyltransferase activity GO:0016279 IDA 19144645 histone-lysine N-methyltransferase activity GO:0018024 IMP 22387026 histone-lysine N-methyltransferase activity GO:0018024 ISS GO:0046974 histone methyltransferase activity (H3-K9 specific) ISS GO:0046976 histone methyltransferase activity (H3-K27 specific) IPI 16702210 C2H2 zinc finger domain binding GO:0070742 IDA 23918802 promoter-specific chromatin binding GO:1990841,hsa00310 Lysine degradation - Homo sapiens (human),CHEMBL CHEMBL2148074,P14902,"Indoleamine 2,3-dioxygenase",1.0,ORTHOGONAL,NO,Oc1ccc(Cl)cc1c2c[nH]nn2,2,5,"InChI=1S/C8H6ClN3O/c9-5-1-2-8(13)6(3-5)7-4-10-12-11-7/h1-4,13H,(H,10,11,12)",NBDFMTBYKCBTSW-UHFFFAOYSA-N,"c(""Indoleamine 2,3-dioxygenase"", ""Tryptophan 2,3-dioxygenase"", ""Unchecked"")",3620,I23O1,R-HSA-1430728 Metabolism R-HSA-71240 Tryptophan catabolism R-HSA-71291 Metabolism of amino acids and derivatives,cytosol TAS GO:0005829 smooth muscle contractile fiber IEA GO:0030485 stereocilium bundle IEA GO:0032421,IEA GO:0002376 immune system process IEA GO:0002534 cytokine production involved in inflammatory response IEA GO:0002666 positive regulation of T cell tolerance induction IEA GO:0002678 positive regulation of chronic inflammatory response IEA GO:0002830 positive regulation of type 2 immune response TAS GO:0006569 tryptophan catabolic process TAS 9712583 female pregnancy GO:0007565 IEA GO:0019441 tryptophan catabolic process to kynurenine IEA GO:0032496 response to lipopolysaccharide IEA GO:0032693 negative regulation of interleukin-10 production IEA GO:0032735 positive regulation of interleukin-12 production IEA GO:0033555 multicellular organismal response to stress IEA GO:0034276 kynurenic acid biosynthetic process IEA GO:0036269 swimming behavior IEA GO:0042130 negative regulation of T cell proliferation IMP NOT 25310899 regulation of activated T cell proliferation GO:0046006 IEA GO:0055114 oxidation-reduction process IEA GO:0070233 negative regulation of T cell apoptotic process IMP 25310899 positive regulation of T cell apoptotic process GO:0070234,"tryptophan 2,3-dioxygenase activity GO:0004833 16477023 EXP electron carrier activity GO:0009055 2109605 TAS heme binding GO:0020037 IEA indoleamine 2,3-dioxygenase activity GO:0033754 25310899 IMP metal ion binding GO:0046872 IEA",hsa00380 Tryptophan metabolism - Homo sapiens (human) hsa05143 African trypanosomiasis - Homo sapiens (human),CHEMBL CHEMBL584991,P14902,"Indoleamine 2,3-dioxygenase",1.0,PRIMARY,NO,Nc1nonc1\C(=N\O)\Nc2ccc(F)c(Cl)c2,2,7,"InChI=1S/C9H7ClFN5O2/c10-5-3-4(1-2-6(5)11)13-9(14-17)7-8(12)16-18-15-7/h1-3,17H,(H2,12,16)(H,13,14)",HGXSLPIXNPASGZ-UHFFFAOYSA-N,"c(""Indoleamine 2,3-dioxygenase"", ""Tryptophan 2,3-dioxygenase"", ""Unchecked"")",3620,I23O1,R-HSA-1430728 Metabolism R-HSA-71240 Tryptophan catabolism R-HSA-71291 Metabolism of amino acids and derivatives,cytosol TAS GO:0005829 smooth muscle contractile fiber IEA GO:0030485 stereocilium bundle IEA GO:0032421,IEA GO:0002376 immune system process IEA GO:0002534 cytokine production involved in inflammatory response IEA GO:0002666 positive regulation of T cell tolerance induction IEA GO:0002678 positive regulation of chronic inflammatory response IEA GO:0002830 positive regulation of type 2 immune response TAS GO:0006569 tryptophan catabolic process TAS 9712583 female pregnancy GO:0007565 IEA GO:0019441 tryptophan catabolic process to kynurenine IEA GO:0032496 response to lipopolysaccharide IEA GO:0032693 negative regulation of interleukin-10 production IEA GO:0032735 positive regulation of interleukin-12 production IEA GO:0033555 multicellular organismal response to stress IEA GO:0034276 kynurenic acid biosynthetic process IEA GO:0036269 swimming behavior IEA GO:0042130 negative regulation of T cell proliferation IMP NOT 25310899 regulation of activated T cell proliferation GO:0046006 IEA GO:0055114 oxidation-reduction process IEA GO:0070233 negative regulation of T cell apoptotic process IMP 25310899 positive regulation of T cell apoptotic process GO:0070234,"tryptophan 2,3-dioxygenase activity GO:0004833 16477023 EXP electron carrier activity GO:0009055 2109605 TAS heme binding GO:0020037 IEA indoleamine 2,3-dioxygenase activity GO:0033754 25310899 IMP metal ion binding GO:0046872 IEA",hsa00380 Tryptophan metabolism - Homo sapiens (human) hsa05143 African trypanosomiasis - Homo sapiens (human),CHEMBL CHEMBL520308,O14920,Inhibitor of nuclear factor kappa B kinase beta subunit,1.0,PRIMARY,NO,CN(CCO)S(=O)(=O)c1ccc(cc1)c2ccnc3[nH]c(C)cc23,6,18,"InChI=1S/C17H19N3O3S/c1-12-11-16-15(7-8-18-17(16)19-12)13-3-5-14(6-4-13)24(22,23)20(2)9-10-21/h3-8,11,21H,9-10H2,1-2H3,(H,18,19)",FKJNWJPAAVSRNX-UHFFFAOYSA-N,"c(""Inhibitor of nuclear factor kappa B kinase beta subunit"", ""Inhibitor of nuclear factor kappa B kinase alpha subunit"", ""A549"", ""Serine/threonine-protein kinase Aurora-B"", ""Aurora kinase A-interacting protein"", ""Glycogen synthase kinase-3 beta"", ""Rho-associated protein kinase 1"", ""Unchecked"")",3551,IKKB,"R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1169091 Activation of NF-kappaB in B cells R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-1606322 ZBP1(DAI) mediated induction of type I IFNs R-HSA-162582 Signal Transduction R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166054 Activated TLR4 signalling R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-166166 MyD88-independent TLR3/TLR4 cascade R-HSA-166520 Signalling by NGF R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168180 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-168638 NOD1/2 Signaling Pathway R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168898 Toll-Like Receptors Cascades R-HSA-168928 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA R-HSA-193639 p75NTR signals via NF-kB R-HSA-193704 p75 NTR receptor-mediated signalling R-HSA-202403 TCR signaling R-HSA-202424 Downstream TCR signaling R-HSA-209543 p75NTR recruits signalling complexes R-HSA-209560 NF-kB is activated and signals survival R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-446652 Interleukin-1 signaling R-HSA-449147 Signaling by Interleukins R-HSA-5607764 CLEC7A (Dectin-1) signaling R-HSA-5621481 C-type lectin receptors (CLRs) R-HSA-933542 TRAF6 mediated NF-kB activation R-HSA-933543 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 R-HSA-937039 IRAK1 recruits IKK complex R-HSA-937041 IKK complex recruitment mediated by RIP1 R-HSA-937061 TRIF-mediated TLR3/TLR4 signaling R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-975871 MyD88 cascade initiated on plasma membrane R-HSA-983705 Signaling by the B Cell Receptor (BCR)",GO:0005634 nucleus IEA GO:0005737 cytoplasm IDA GO:0005829 cytosol TAS GO:0008385 IkappaB kinase complex 18626576 TAS GO:0009898 cytoplasmic side of plasma membrane ISS GO:0035631 CD40 receptor complex ISS GO:0045121 membrane raft IEA,"stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS skeletal muscle contraction GO:0003009 IEA protein phosphorylation GO:0006468 15084260 20434986 IDA protein phosphorylation GO:0006468 9346484 NAS inflammatory response GO:0006954 18626576 TAS I-kappaB kinase/NF-kappaB signaling GO:0007249 25816133 IMP I-kappaB kinase/NF-kappaB signaling GO:0007249 18626576 TAS I-kappaB phosphorylation GO:0007252 IEA positive regulation of cell proliferation GO:0008284 IEA response to virus GO:0009615 18626576 TAS response to toxic substance GO:0009636 IEA regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 TAS positive regulation of neuron projection development GO:0010976 IEA cortical actin cytoskeleton organization GO:0030866 25816133 IMP neuron projection development GO:0031175 IEA response to lipopolysaccharide GO:0032496 IEA tumor necrosis factor-mediated signaling pathway GO:0033209 15084260 25816133 IMP negative regulation of myosin-light-chain-phosphatase activity GO:0035509 25816133 IMP TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS Fc-epsilon receptor signaling pathway GO:0038095 TAS regulation of phosphorylation GO:0042325 26212789 IDA response to drug GO:0042493 IEA serine phosphorylation of STAT protein GO:0042501 21399639 IDA negative regulation of apoptotic process GO:0043066 TAS positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 TAS innate immune response GO:0045087 18626576 TAS positive regulation of transcription, DNA-templated GO:0045893 9346484 9346485 9813230 NAS positive regulation of transcription from RNA polymerase II promoter GO:0045944 23091055 23453807 IDA T cell receptor signaling pathway GO:0050852 TAS positive regulation of NF-kappaB transcription factor activity GO:0051092 15790681 IDA positive regulation of NF-kappaB transcription factor activity GO:0051092 18626576 TAS stress-activated MAPK cascade GO:0051403 TAS nucleotide-binding oligomerization domain containing signaling pathway GO:0070423 TAS interleukin-1-mediated signaling pathway GO:0070498 25816133 IMP response to fatty acid GO:0070542 IEA cellular response to tumor necrosis factor GO:0071356 23091055 IDA establishment of protein localization to plasma membrane GO:0090002 25816133 IMP positive regulation of neuron death GO:1901216 IEA regulation of establishment of endothelial barrier GO:1903140 25816133 IMP negative regulation of bicellular tight junction assembly GO:1903347 25816133 IMP",protein kinase activity 20434986 GO:0004672 IDA protein serine/threonine kinase activity 15084260 GO:0004674 IDA protein serine/threonine kinase activity GO:0004674 TAS protein binding 9520446 9751060 10521409 10733566 11971985 12486103 12842894 14743216 15084260 15389287 15601829 15749833 16126728 16129692 16286467 16319058 16365431 16938294 17568778 17693255 18266467 18930133 19345327 19365808 19675099 20098747 20434986 20600852 21399639 21474709 21765415 21903422 22037600 22810585 23091055 23104095 24618592 25036637 25241761 25759022 25852190 26212789 26496610 GO:0005515 IPI ATP binding GO:0005524 IEA IkappaB kinase activity 18626576 GO:0008384 TAS protein kinase binding 12492477 GO:0019901 IPI protein homodimerization activity 23091055 GO:0042803 IDA protein heterodimerization activity 23091055 GO:0046982 IDA scaffold protein binding 23776175 GO:0097110 IDA,MAPK signaling pathway - Homo sapiens (human) hsa04010 Ras signaling pathway - Homo sapiens (human) hsa04014 Chemokine signaling pathway - Homo sapiens (human) hsa04062 NF-kappa B signaling pathway - Homo sapiens (human) hsa04064 FoxO signaling pathway - Homo sapiens (human) hsa04068 mTOR signaling pathway - Homo sapiens (human) hsa04150 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Apoptosis - Homo sapiens (human) hsa04210 Osteoclast differentiation - Homo sapiens (human) hsa04380 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04620 NOD-like receptor signaling pathway - Homo sapiens (human) hsa04621 RIG-I-like receptor signaling pathway - Homo sapiens (human) hsa04622 Cytosolic DNA-sensing pathway - Homo sapiens (human) hsa04623 T cell receptor signaling pathway - Homo sapiens (human) hsa04660 B cell receptor signaling pathway - Homo sapiens (human) hsa04662 TNF signaling pathway - Homo sapiens (human) hsa04668 Neurotrophin signaling pathway - Homo sapiens (human) hsa04722 Insulin signaling pathway - Homo sapiens (human) hsa04910 Adipocytokine signaling pathway - Homo sapiens (human) hsa04920 Type II diabetes mellitus - Homo sapiens (human) hsa04930 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa04932 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) hsa05120 Shigellosis - Homo sapiens (human) hsa05131 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05142 Toxoplasmosis - Homo sapiens (human) hsa05145 Hepatitis C - Homo sapiens (human) hsa05160 Hepatitis B - Homo sapiens (human) hsa05161 Influenza A - Homo sapiens (human) hsa05164 HTLV-I infection - Homo sapiens (human) hsa05166 Herpes simplex infection - Homo sapiens (human) hsa05168 Epstein-Barr virus infection - Homo sapiens (human) hsa05169 Pathways in cancer - Homo sapiens (human) hsa05200 MicroRNAs in cancer - Homo sapiens (human) hsa05206 Pancreatic cancer - Homo sapiens (human) hsa05212 Prostate cancer - Homo sapiens (human) hsa05215 Chronic myeloid leukemia - Homo sapiens (human) hsa05220 Acute myeloid leukemia - Homo sapiens (human) hsa05221 Small cell lung cancer - Homo sapiens (human) hsa05222,CHEMBL CHEMBL3601192,Q9NWZ3,Interleukin-1 receptor-associated kinase 4,1.0,PRIMARY,NO,Cc1cc(Nc2ncc(c(N[C@@H]3C[C@H](CO)[C@@H](O)[C@H]3O)n2)c4ccc5ccccc5n4)cc(C)n1,2,4,"InChI=1S/C26H28N6O3/c1-14-9-18(10-15(2)28-14)29-26-27-12-19(21-8-7-16-5-3-4-6-20(16)30-21)25(32-26)31-22-11-17(13-33)23(34)24(22)35/h3-10,12,17,22-24,33-35H,11,13H2,1-2H3,(H2,27,28,29,31,32)/t17-,22-,23-,24+/m1/s1",LKWUVRWXZPRGNM-BMZZKGLRSA-N,"c(""Interleukin-1 receptor-associated kinase 4"", ""Tumor necrosis factor receptor R1"")",51135,IRAK4,Cytokine Signaling in Immune system R-HSA-1280215 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 Activated TLR4 signalling R-HSA-166054 MyD88:Mal cascade initiated on plasma membrane R-HSA-166058 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Toll-Like Receptors Cascades R-HSA-168898 Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 Interleukin-1 signaling R-HSA-446652 Signaling by Interleukins R-HSA-449147 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 MyD88 dependent cascade initiated on endosome R-HSA-975155 MyD88 cascade initiated on plasma membrane R-HSA-975871,extracellular space GO:0005615 IEA nucleus GO:0005634 IBA cytoplasm GO:0005737 IBA cytosol GO:0005829 TAS plasma membrane GO:0005886 TAS endosome membrane GO:0010008 TAS,cytokine production GO:0001816 IEA toll-like receptor signaling pathway 21269878 GO:0002224 TAS neutrophil mediated immunity 19663824 GO:0002446 IMP MyD88-dependent toll-like receptor signaling pathway 21269878 GO:0002755 TAS JNK cascade GO:0007254 IEA cytokine-mediated signaling pathway GO:0019221 IEA toll-like receptor 9 signaling pathway GO:0034162 TAS positive regulation of I-kappaB kinase/NF-kappaB signaling 22158417 GO:0043123 IMP innate immune response 21269878 GO:0045087 TAS positive regulation of smooth muscle cell proliferation GO:0048661 IEA neutrophil migration 19663824 GO:1990266 IMP,GO:0000287 magnesium ion binding IEA 11960013 GO:0004672 protein kinase activity EXP 11960013 GO:0004674 protein serine/threonine kinase activity EXP GO:0004674 protein serine/threonine kinase activity IBA GO:0004674 protein serine/threonine kinase activity TAS GO:0005149 interleukin-1 receptor binding IEA 12860405 21903422 23376919 24316379 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA,hsa04064 NF-kappa B signaling pathway - Homo sapiens (human) hsa04210 Apoptosis - Homo sapiens (human) hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa05133 Pertussis - Homo sapiens (human) hsa05140 Leishmaniasis - Homo sapiens (human) hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05152 Tuberculosis - Homo sapiens (human) hsa05162 Measles - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human),CHEMBL CHEMBL498270,O15554,Intermediate conductance calcium-activated potassium channel protein 4,1.0,PRIMARY,NO,Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4cccn4,2,9,"InChI=1S/C22H17ClN2/c23-21-15-8-7-14-20(21)22(25-17-9-16-24-25,18-10-3-1-4-11-18)19-12-5-2-6-13-19/h1-17H",KBFUQFVFYYBHBT-UHFFFAOYSA-N,"c(""Voltage-gated potassium channel subunit Kv1.3"", ""Intermediate conductance calcium-activated potassium channel protein 4"", ""HaCaT"", ""Unchecked"", ""Runt-related transcription factor 1/Core-binding factor subunit beta"")",3783,KCNN4,R-HSA-112316 Neuronal System R-HSA-1296052 Ca2+ activated K+ channels R-HSA-1296071 Potassium Channels,IDA 26148990 plasma membrane GO:0005886 TAS GO:0005886 plasma membrane IC 18796614 voltage-gated potassium channel complex GO:0008076 IEA GO:0016323 basolateral plasma membrane IEA GO:0016324 apical plasma membrane IEA GO:0043025 neuronal cell body IEA GO:0045121 membrane raft,GO:0002376 immune system process IEA 9380751 GO:0006813 potassium ion transport TAS 18796614 GO:0006816 calcium ion transport IDA GO:0006884 cell volume homeostasis IEA 9407042 GO:0006952 defense response TAS 18796614 GO:0030322 stabilization of membrane potential IDA GO:0045332 phospholipid translocation IEA GO:0046541 saliva secretion IEA GO:0050714 positive regulation of protein secretion IEA 18796614 GO:0050862 positive regulation of T cell receptor signaling pathway IDA GO:0071435 potassium ion export IEA,potassium channel activity TAS GO:0005267 protein binding IPI 12198491 GO:0005515 calmodulin binding IEA GO:0005516 calcium-activated potassium channel activity IDA 18796614 26148990 GO:0015269 small conductance calcium-activated potassium channel activity IEA GO:0016286 protein phosphatase binding IPI 18796614 GO:0019903 Intermediate conductance calcium-activated potassium channel activity IEA GO:0022894,hsa04911 Insulin secretion - Homo sapiens (human) hsa04970 Salivary secretion - Homo sapiens (human) hsa04974 Protein digestion and absorption - Homo sapiens (human),CHEMBL CHEMBL2180639,P41145,Kappa opioid receptor,1.0,PRIMARY,NO,Oc1cccc(CCN(CCc2ccccc2)CC3CCC3)c1,6,14,"InChI=1S/C21H27NO/c23-21-11-5-8-19(16-21)13-15-22(17-20-9-4-10-20)14-12-18-6-2-1-3-7-18/h1-3,5-8,11,16,20,23H,4,9-10,12-15,17H2",YNVKFHIWFDRVNY-UHFFFAOYSA-N,"c(""Dopamine D3 receptor"", ""Dopamine D2 receptor"", ""Dopamine D1 receptor"", ""Kappa opioid receptor"", ""Unchecked"", ""Delta opioid receptor"", ""Mu opioid receptor"")",4986,OPRK,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,TAS GO:0005886 plasma membrane 7624359 IMP GO:0005887 integral component of plasma membrane 22437504 IDA GO:0016021 integral component of membrane IEA GO:0030425 dendrite IBA GO:0043005 neuron projection IEA GO:0043204 perikaryon IEA GO:0043679 axon terminus IEA GO:0045202 synapse,8755601 GO:0006955 immune response IDA 7624359 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS GO:0007218 neuropeptide signaling pathway IBA 7624359 GO:0007268 chemical synaptic transmission TAS 7624359 GO:0007600 sensory perception TAS 7624359 GO:0007610 behavior TAS GO:0007626 locomotory behavior ISS GO:0009314 response to radiation IEA GO:0019233 sensory perception of pain IBA GO:0019233 sensory perception of pain ISS 22437504 GO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway IDA GO:0032868 response to insulin IEA GO:0033603 positive regulation of dopamine secretion IEA GO:0033685 negative regulation of luteinizing hormone secretion IEA 8755601 GO:0038003 opioid receptor signaling pathway IDA GO:0040017 positive regulation of locomotion IEA GO:0042711 maternal behavior IEA GO:0042755 eating behavior IEA GO:0043278 response to morphine IEA GO:0043627 response to estrogen IEA GO:0044849 estrous cycle IEA GO:0045471 response to ethanol IEA GO:0046877 regulation of saliva secretion ISS GO:0048148 behavioral response to cocaine IEA GO:0050951 sensory perception of temperature stimulus IEA 8755601 GO:0051607 defense response to virus IDA GO:0051930 regulation of sensory perception of pain IEA GO:0071222 cellular response to lipopolysaccharide IEA GO:1900745 positive regulation of p38MAPK cascade IEA GO:1901381 positive regulation of potassium ion transmembrane transport IEA GO:1903715 regulation of aerobic respiration IEA GO:1903937 response to acrylamide IEA GO:1990708 conditioned place preference IEA GO:2000505 regulation of energy homeostasis IEA,22437504 GO:0004985 opioid receptor activity IDA 16431922 GO:0005515 protein binding IPI 8755601 GO:0038048 dynorphin receptor activity IDA 7624359 GO:0038048 dynorphin receptor activity IMP GO:0042923 neuropeptide binding IBA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL445332,P41145,Kappa opioid receptor,1.0,ORTHOGONAL,YES,COC(=O)[C@@H]1C[C@H](OC(=O)C)C(=O)[C@H]2[C@@]1(C)CC[C@H]3C(=O)O[C@@H](C[C@]23C)c4cocc4,4,140,"InChI=1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1",OBSYBRPAKCASQB-AGQYDFLVSA-N,"c(""Mu opioid receptor"", ""Kappa opioid receptor"", ""Delta opioid receptor"", ""Opioid receptors; delta & kappa"", ""Opioid receptors; mu & kappa"", ""Unchecked"", ""Tyrosyl-DNA phosphodiesterase 1"", ""Histone acetyltransferase GCN5"", ""Histone-lysine N-methyltransferase, H3 lysine-9 specific 3"", ""Runt-related transcription factor 1/Core-binding factor subunit beta"", ""Vitamin D receptor"", ""MCF7"")",4986,OPRK,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,TAS GO:0005886 plasma membrane 7624359 IMP GO:0005887 integral component of plasma membrane 22437504 IDA GO:0016021 integral component of membrane IEA GO:0030425 dendrite IBA GO:0043005 neuron projection IEA GO:0043204 perikaryon IEA GO:0043679 axon terminus IEA GO:0045202 synapse,8755601 GO:0006955 immune response IDA 7624359 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS GO:0007218 neuropeptide signaling pathway IBA 7624359 GO:0007268 chemical synaptic transmission TAS 7624359 GO:0007600 sensory perception TAS 7624359 GO:0007610 behavior TAS GO:0007626 locomotory behavior ISS GO:0009314 response to radiation IEA GO:0019233 sensory perception of pain IBA GO:0019233 sensory perception of pain ISS 22437504 GO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway IDA GO:0032868 response to insulin IEA GO:0033603 positive regulation of dopamine secretion IEA GO:0033685 negative regulation of luteinizing hormone secretion IEA 8755601 GO:0038003 opioid receptor signaling pathway IDA GO:0040017 positive regulation of locomotion IEA GO:0042711 maternal behavior IEA GO:0042755 eating behavior IEA GO:0043278 response to morphine IEA GO:0043627 response to estrogen IEA GO:0044849 estrous cycle IEA GO:0045471 response to ethanol IEA GO:0046877 regulation of saliva secretion ISS GO:0048148 behavioral response to cocaine IEA GO:0050951 sensory perception of temperature stimulus IEA 8755601 GO:0051607 defense response to virus IDA GO:0051930 regulation of sensory perception of pain IEA GO:0071222 cellular response to lipopolysaccharide IEA GO:1900745 positive regulation of p38MAPK cascade IEA GO:1901381 positive regulation of potassium ion transmembrane transport IEA GO:1903715 regulation of aerobic respiration IEA GO:1903937 response to acrylamide IEA GO:1990708 conditioned place preference IEA GO:2000505 regulation of energy homeostasis IEA,22437504 GO:0004985 opioid receptor activity IDA 16431922 GO:0005515 protein binding IPI 8755601 GO:0038048 dynorphin receptor activity IDA 7624359 GO:0038048 dynorphin receptor activity IMP GO:0042923 neuropeptide binding IBA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL2180640,P41145,Kappa opioid receptor,1.0,PRIMARY,YES,CCCCN(CCc1ccccc1)CCc2cccc(O)c2,6,10,"InChI=1S/C20H27NO/c1-2-3-14-21(15-12-18-8-5-4-6-9-18)16-13-19-10-7-11-20(22)17-19/h4-11,17,22H,2-3,12-16H2,1H3",SDERQNAMIWOFFX-UHFFFAOYSA-N,"c(""Dopamine D3 receptor"", ""Dopamine D2 receptor"", ""Dopamine D1 receptor"", ""Kappa opioid receptor"", ""Unchecked"", ""Delta opioid receptor"", ""Mu opioid receptor"")",4986,OPRK,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,TAS GO:0005886 plasma membrane 7624359 IMP GO:0005887 integral component of plasma membrane 22437504 IDA GO:0016021 integral component of membrane IEA GO:0030425 dendrite IBA GO:0043005 neuron projection IEA GO:0043204 perikaryon IEA GO:0043679 axon terminus IEA GO:0045202 synapse,8755601 GO:0006955 immune response IDA 7624359 GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS GO:0007218 neuropeptide signaling pathway IBA 7624359 GO:0007268 chemical synaptic transmission TAS 7624359 GO:0007600 sensory perception TAS 7624359 GO:0007610 behavior TAS GO:0007626 locomotory behavior ISS GO:0009314 response to radiation IEA GO:0019233 sensory perception of pain IBA GO:0019233 sensory perception of pain ISS 22437504 GO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway IDA GO:0032868 response to insulin IEA GO:0033603 positive regulation of dopamine secretion IEA GO:0033685 negative regulation of luteinizing hormone secretion IEA 8755601 GO:0038003 opioid receptor signaling pathway IDA GO:0040017 positive regulation of locomotion IEA GO:0042711 maternal behavior IEA GO:0042755 eating behavior IEA GO:0043278 response to morphine IEA GO:0043627 response to estrogen IEA GO:0044849 estrous cycle IEA GO:0045471 response to ethanol IEA GO:0046877 regulation of saliva secretion ISS GO:0048148 behavioral response to cocaine IEA GO:0050951 sensory perception of temperature stimulus IEA 8755601 GO:0051607 defense response to virus IDA GO:0051930 regulation of sensory perception of pain IEA GO:0071222 cellular response to lipopolysaccharide IEA GO:1900745 positive regulation of p38MAPK cascade IEA GO:1901381 positive regulation of potassium ion transmembrane transport IEA GO:1903715 regulation of aerobic respiration IEA GO:1903937 response to acrylamide IEA GO:1990708 conditioned place preference IEA GO:2000505 regulation of energy homeostasis IEA,22437504 GO:0004985 opioid receptor activity IDA 16431922 GO:0005515 protein binding IPI 8755601 GO:0038048 dynorphin receptor activity IDA 7624359 GO:0038048 dynorphin receptor activity IMP GO:0042923 neuropeptide binding IBA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL2017214,P50053,Ketohexokinase,1.0,PRIMARY,NO,CSc1ccccc1Nc2nc(nc3c(NCC4CC4)ncnc23)N5CCNCC5,33,40,"InChI=1S/C21H26N8S/c1-30-16-5-3-2-4-15(16)26-20-17-18(19(25-13-24-17)23-12-14-6-7-14)27-21(28-20)29-10-8-22-9-11-29/h2-5,13-14,22H,6-12H2,1H3,(H,23,24,25)(H,26,27,28)",HFLMLZKGLUEWBU-UHFFFAOYSA-N,"c(""Ketohexokinase"", ""Tyrosine-protein kinase ABL"", ""Activin receptor type-1B"", ""Serine/threonine-protein kinase AKT"", ""AMP-activated protein kinase, alpha-1 subunit"", ""AMP-activated protein kinase, beta-1 subunit"", ""AMP-activated protein kinase, gamma-1 subunit"", ""Serine/threonine-protein kinase Aurora-A"", ""CaM kinase I delta"", ""CaM kinase II alpha"", ""Cyclin-dependent kinase 1/cyclin B1"", ""Serine/threonine-protein kinase Chk1"", ""Serine/threonine-protein kinase Chk2"", ""Casein kinase I delta"", ""Death-associated protein kinase 3"", ""Epidermal growth factor receptor erbB1"", ""Ephrin type-B receptor 1"", ""Glycogen synthase kinase-3 beta"", ""Insulin receptor"", ""Interleukin-1 receptor-associated kinase 4"", ""Tyrosine-protein kinase JAK2"", ""MAP kinase p38 delta"", ""Serine/threonine-protein kinase MST4"", ""Serine/threonine-protein kinase NEK2"", ""Nerve growth factor receptor Trk-A"", ""Serine/threonine-protein kinase PAK 3"", ""Platelet-derived growth factor receptor beta"", ""Serine/threonine-protein kinase PIM2"", ""Serine/threonine-protein kinase PLK3"", ""cAMP-dependent protein kinase alpha-catalytic subunit"", ""Protein kinase C theta"", ""Rho-associated protein kinase 1"", ""Ribosomal protein S6 kinase alpha 3"", ""Tyrosine-protein kinase SRC"", ""Unchecked"")",3795,KHK,Metabolism R-HSA-1430728 Fructose metabolism R-HSA-5652084 Fructose catabolism R-HSA-70350 Metabolism of carbohydrates R-HSA-71387,IDA GO:0005737 cytoplasm TAS GO:0005829 cytosol 19056867 23376485 IDA GO:0070062 extracellular exosome,response to sucrose IEA GO:0009744 response to glucose IEA GO:0009749 response to fructose IEA GO:0009750 response to zinc ion IEA GO:0010043 response to insulin IEA GO:0032868 carbohydrate phosphorylation IEA GO:0046835 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate TAS GO:0061624,GO:0004454 ketohexokinase activity 12941785 19237742 EXP GO:0004454 ketohexokinase activity 12941785 IDA GO:0005515 protein binding 25416956 IPI GO:0005524 ATP binding IEA,Fructose and mannose metabolism - Homo sapiens (human) hsa00051,CHEMBL CHEMBL392695,P52732,Kinesin-like protein 1,1.0,PRIMARY,NO,N[C@@H](CSC(c1ccccc1)(c2ccccc2)c3ccccc3)C(=O)O,3,403,"InChI=1S/C22H21NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20H,16,23H2,(H,24,25)/t20-/m0/s1",DLMYFMLKORXJPO-FQEVSTJZSA-N,"c(""HeLa"", ""Kinesin-like protein 1"", ""Kinesin-like protein KIF23"", ""Chromosome-associated kinesin KIF4A"", ""Unchecked"", ""CCRF-CEM"", ""HL-60"", ""K562"", ""MOLT-4"", ""SR"", ""A549"", ""EKVX"", ""HOP-62"", ""NCI-H226"", ""NCI-H23"", ""NCI-H322M"", ""NCI-H522"", ""COLO 205"", ""HCC 2998"", ""HCT-116"", ""HCT-15"", ""HT-29"", ""KM12"", ""SW-620"", ""SF-268"", ""SF-295"", ""SF-539"", ""SNB-19"", ""SNB-75"", ""U-251"", ""LOX IMVI"", ""Malme-3M"", ""M14"", ""SK-MEL-2"", ""SK-MEL-28"", ""SK-MEL-5"", ""UACC-257"", ""UACC-62"", ""IGROV-1"", ""OVCAR-3"", ""OVCAR-4"", ""OVCAR-5"", ""OVCAR-8"", ""SK-OV-3"", ""786-0"", ""ACHN"", ""CAKI-1"", ""SN12C"", ""TK-10"", ""UO-31"", ""NCI-H1299"", ""BXPC-3"", ""PC-3"", ""LNCaP"", ""DSH1"", ""Daudi"", ""DU-4475"", ""EHEB"", ""EM-2"", ""ES1"", ""ES4"", ""EB-3"", ""EC-GI-10"", ""ECC4"", ""C2BBe1"", ""COLO-800"", ""DG-75"", ""DJM-1"", ""DMS-114"", ""ACN"", ""CA46"", ""DMS-79"", ""DOHH-2"", ""ALL-PO"", ""COR-L279"", ""COR-L88"", ""DMS-153"", ""CAL-148"", ""CP66-MEL"", ""ARH-77"", ""ATN-1"", ""CP67-MEL"", ""CPC-N"", ""CTB-1"", ""BB30-HNC"", ""CTV-1"", ""697"", ""BB65-RCC"", ""BC1 cell line"", ""8-MG-BA"", ""BC-3"", ""BE-13"", ""Calu-6"", ""A101D"", ""CESS"", ""CGTH-W-1"", ""CHP-126"", ""A253 cell line"", ""BL-41"", ""BL-70"", ""BOKU"", ""CMK"", ""D-336MG"", ""A3-KAW"", ""COLO-320-HSR"", ""COLO-668"", ""A388"", ""A4-Fuk"", ""BT-474"", ""BV-173"", ""DB"", ""Becker"", ""COLO-684"", ""DEL"", ""NCI-H187"", ""NCI-H526"", ""OMC-1"", ""RPMI-8226"", ""TGW"", ""THP-1"", ""GI-1"", ""GI-ME-N"", ""IST-SL1"", ""IST-SL2"", ""KS-1"", ""LOUCY"", ""MFH-ino"", ""NB13"", ""NB14"", ""NCI-H1882"", ""NCI-H1963"", ""NCI-H64"", ""ONS-76"", ""OPM-2"", ""RPMI 8402"", ""RPMI-8866"", ""SW684"", ""GOTO"", ""J-RT3-T3-5"", ""KU812 cell line"", ""KURAMOCHI"", ""LP-1"", ""NB17"", ""NB5"", ""NCI-H69"", ""OS-RC-2"", ""RS4-11"", ""GR-ST"", ""JAR"", ""KY821"", ""LS-1034"", ""LS-123"", ""MHH-NB-11"", ""MHH-PREB-1"", ""NB6"", ""NB69"", ""NCI-H719"", ""RXF 393"", ""SK-MM-2"", ""SW872"", ""U-266"", ""ES6"", ""GT3TKB"", ""LS-411N"", ""LS-513"", ""NB7"", ""NCI-H209"", ""NCI-H747"", ""Raji"", ""Ramos-2G6-4C10"", ""SK-N-DZ"", ""SW 954"", ""ES8"", ""HAL-01"", ""JIYOYE"", ""LU-134-A"", ""NCCIT"", ""NCI-H1092"", ""NCI-H2107"", ""NCI-H2126"", ""NCI-H748"", ""SBC-1"", ""SK-N-FI"", ""SK-NEP-1"", ""SW 962"", ""SW982"", ""ETK-1"", ""EVSA-T"", ""HC-1"", ""HCC1187"", ""HT"", ""K052"", ""K5"", ""KALS-1"", ""LU-139"", ""LU-165"", ""ML-2"", ""MLMA"", ""NCI-H1155"", ""NCI-H2141"", ""NCI-H82"", ""NCI-H889"", ""SCC-15"", ""SK-PN-DW"", ""EW-1"", ""KARPAS-299"", ""L-363"", ""Lu-65"", ""MMAC-SF"", ""NCI-H1304"", ""NCI-H1355"", ""NCI-H2171"", ""NCI-H2196"", ""SNU1"", ""SCC-3"", ""SK-UT-1"", ""HCC1599"", ""HT-144"", ""KARPAS-422"", ""KARPAS-45"", ""L-428"", ""L-540"", ""LAMA-84"", ""LXF-289 cell line"", ""MN-60"", ""MOLT-16"", ""NCI-H1395"", ""SNU-16"", ""SNU-5"", ""NEC8"", ""PF-382"", ""VA-ES-BJ"", ""EW-16"", ""KE-37"", ""LAN-6"", ""MC-CAR"", ""MONO-MAC-6"", ""NCI-H1417"", ""NCI-H1436"", ""PSN1"", ""QIMR-WIL"", ""SCH"", ""SCLC-21H"", ""SF-126"", ""TALL-1"", ""TE-1"", ""EW-24"", ""HCC2157"", ""HCC2218"", ""HuTu80"", ""KGN"", ""KINGS-1"", ""LB1047-RCC"", ""MC116"", ""MPP-89"", ""MRK-nu-1"", ""NCI-H1522"", ""NKM-1"", ""NMC-G1"", ""RCC10RGB"", ""SNU-C1"", ""TE-10"", ""TE-11"", ""EW-3"", ""EOL1"", ""KLE"", ""LB2518-MEL"", ""LB373-MEL-D"", ""MDA-MB-134-VI"", ""MS-1"", ""NCI-H1581"", ""NOMO-1"", ""NOS-1"", ""SNU-C2B"", ""ST486"", ""TE-12"", ""HCE-4"", ""KM-H2"", ""LB647-SCLC"", ""LB771-HNC"", ""MV4-11"", ""MZ1-PC"", ""NCI-H1648"", ""NCI-H345"", ""NTERA-2-cl-D1"", ""RH-1"", ""SH-4"", ""SHP77"", ""TE-15"", ""TE-441-T"", ""TE-5"", ""no-10"", ""no-11"", ""HCE-T"", ""IA-LM"", ""KMOE-2"", ""KMS-12-PE"", ""KNS-42"", ""LB831-BLC"", ""LB996-RCC"", ""MZ2-MEL"", ""NCI-H1650"", ""NCI-H446"", ""RKO"", ""SIG-M5"", ""TE-6"", ""TE-8"", ""GAK"", ""HD-MY-Z"", ""HDLM-2"", ""KNS-81-FD"", ""LC-1F"", ""LC-2-ad"", ""MEG-01"", ""MZ7-mel"", ""NCI-H1694"", ""NCI-H510A"", ""OCI-AML2"", ""RL95-2"", ""SJSA-1"", ""TE-9"", ""GB-1"", ""GCIY"", ""HEL"", ""IMR-5"", ""LC4-1"", ""NALM-6"", ""NB1"", ""NCI-H1770"", ""NCI-H524"", ""OCUB-M"", ""RPMI-6666"", ""SK-LMS-1"", ""TGBC1TKB"", ""TGBC24TKB"", ""GDM-1"", ""HH"", ""IST-MEL1"", ""IST-MES1"", ""KP-N-RT-BM-1"", ""KP-N-YS"", ""NB10"")",3832,KIF11,Hemostasis R-HSA-109582 Kinesins R-HSA-983189 Factors involved in megakaryocyte development and platelet production R-HSA-983231,spindle pole GO:0000922 14718566 IDA colocalizes_with cytoplasm GO:0005737 IDA spindle GO:0005819 19001501 IDA cytosol GO:0005829 TAS kinesin complex GO:0005871 8548803 TAS microtubule GO:0005874 21525035 IDA spindle microtubule GO:0005876 14718566 IDA colocalizes_with membrane GO:0016020 19946888 IDA,"GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS GO:0007018 microtubule-based movement IBA GO:0007018 microtubule-based movement TAS GO:0007051 spindle organization 14718566 IMP GO:0007052 mitotic spindle organization 8548803 TAS GO:0007059 chromosome segregation IBA GO:0007067 mitotic nuclear division 8548803 TAS GO:0007100 mitotic centrosome separation IEA GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS GO:0046602 regulation of mitotic centrosome separation 15843429 IMP GO:0051301 cell division IEA GO:0090307 mitotic spindle assembly 19001501 IDA GO:0090307 mitotic spindle assembly 15843429 IMP","microtubule motor activity GO:0003777 TAS 8548803 ATP binding GO:0005524 IEA microtubule binding GO:0008017 IEA ATP-dependent microtubule motor activity, plus-end-directed GO:0008574 IBA protein kinase binding GO:0019901 IPI 19001501 protein complex binding GO:0032403 IDA 17707232",,CHEMBL CHEMBL1098726,P20701,Leukocyte adhesion glycoprotein LFA-1 alpha,1.0,PRIMARY,NO,CN1C(=O)N(C(=O)[C@]12CN(C[C@H]2c3ccc(cc3)C#N)c4ccc(cn4)C(=O)O)c5cc(Cl)cc(Cl)c5,2,8,"InChI=1S/C26H19Cl2N5O4/c1-31-25(37)33(20-9-18(27)8-19(28)10-20)24(36)26(31)14-32(22-7-6-17(12-30-22)23(34)35)13-21(26)16-4-2-15(11-29)3-5-16/h2-10,12,21H,13-14H2,1H3,(H,34,35)/t21-,26+/m0/s1",LILGMDXLRPEBNH-HFZDXXHNSA-N,"c(""Leukocyte adhesion glycoprotein LFA-1 alpha"", ""Integrin alpha M"", ""Unchecked"")",3683,ITAL,R-HSA-109582 Hemostasis R-HSA-1280218 Adaptive Immune System R-HSA-1474244 Extracellular matrix organization R-HSA-168256 Immune System R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-216083 Integrin cell surface interactions,plasma membrane GO:0005886 TAS integrin complex 8103515 GO:0008305 NAS cell surface 19029120 19234460 23981064 GO:0009986 IDA membrane 19946888 GO:0016020 IDA integrin alphaL-beta2 complex 19029120 GO:0034687 IDA extracellular exosome 20458337 GO:0070062 IDA,T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:0002291 IMP 2477710 movement of cell or subcellular component GO:0006928 TAS 10477596 inflammatory response GO:0006954 NAS 8103515 cell adhesion GO:0007155 NAS 8103515 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 IMP 2477710 leukocyte cell-cell adhesion GO:0007159 IMP 2477710 cell-matrix adhesion GO:0007160 IMP 19029120 signal transduction GO:0007165 NAS 8103515 integrin-mediated signaling pathway GO:0007229 IEA extracellular matrix organization GO:0030198 TAS receptor clustering GO:0043113 IMP 19029120 regulation of immune response GO:0050776 TAS leukocyte migration GO:0050900 TAS,IPI 11544294 15946252 18985028 protein binding GO:0005515 IMP 19029120 ICAM-3 receptor activity GO:0030369 IEA GO:0032403 protein complex binding IEA GO:0046872 metal ion binding IEA GO:0046982 protein heterodimerization activity IMP 19029120 cell adhesion molecule binding GO:0050839 IPI 1448173 cell adhesion molecule binding GO:0050839,Rap1 signaling pathway - Homo sapiens (human) hsa04015 Cell adhesion molecules (CAMs) - Homo sapiens (human) hsa04514 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04650 Leukocyte transendothelial migration - Homo sapiens (human) hsa04670 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04810 Malaria - Homo sapiens (human) hsa05144 Staphylococcus aureus infection - Homo sapiens (human) hsa05150 HTLV-I infection - Homo sapiens (human) hsa05166 Epstein-Barr virus infection - Homo sapiens (human) hsa05169 Rheumatoid arthritis - Homo sapiens (human) hsa05323 Viral myocarditis - Homo sapiens (human) hsa05416,CHEMBL CHEMBL2338554,P08246,Leukocyte elastase,1.0,PRIMARY,NO,[Na+].CC[C@@H](C)[C@@H]1NC(=O)[C@H](Cc2ccccc2)N(C)C(=O)[C@H](Cc3ccccc3)N4[C@H](O)CC[C@H](NC(=O)\C(=C\C)\NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](COS(=O)(=O)[O-])OC)C(C)C)[C@@H](C)OC1=O)C4=O,61,107,"InChI=1S/C47H65N7O15S.Na/c1-9-27(5)38-47(63)69-28(6)39(52-43(59)37(26(3)4)50-42(58)35(67-8)25-68-70(64,65)66)44(60)48-31(10-2)40(56)49-32-21-22-36(55)54(45(32)61)34(24-30-19-15-12-16-20-30)46(62)53(7)33(41(57)51-38)23-29-17-13-11-14-18-29;/h10-20,26-28,32-39,55H,9,21-25H2,1-8H3,(H,48,60)(H,49,56)(H,50,58)(H,51,57)(H,52,59)(H,64,65,66);/q;+1/p-1/b31-10-;/t27-,28-,32+,33+,34+,35-,36-,37+,38+,39+;/m1./s1",KPKJQINJXGFAPS-NBGICTFWSA-M,"c(""Urokinase-type plasminogen activator"", ""Tryptase gamma"", ""Tryptase beta-1"", ""Unchecked"", ""Tissue-type plasminogen activator"", ""Plasminogen"", ""Plasma kallikrein"", ""Kallikrein 14"", ""Kallikrein 13"", ""Kallikrein 12"", ""Kallikrein 8"", ""Kallikrein 5"", ""Kallikrein 1"", ""Granzyme B"", ""Coagulation factor XI"", ""Coagulation factor X"", ""Coagulation factor VII"", ""Leukocyte elastase"", ""Complement C1s"", ""Vitamin K-dependent protein C"", ""Cathepsin E"", ""Cathepsin D"", ""Beta-secretase 1"", ""ADAM17"", ""ADAM10"", ""ADAM9"", ""Matrix metalloproteinase 14"", ""Matrix metalloproteinase 13"", ""Matrix metalloproteinase 12"", ""Matrix metalloproteinase 11"", ""Matrix metalloproteinase 10"", ""Matrix metalloproteinase 9"", ""Matrix metalloproteinase 8"", ""Matrix metalloproteinase 7"", ""Matrix metalloproteinase 3"", ""Matrix metalloproteinase-2"", ""Matrix metalloproteinase-1"", ""Angiotensin-converting enzyme"", ""Cathepsin Z"", ""Cathepsin L2"", ""Cathepsin S"", ""Cathepsin K"", ""Cathepsin H"", ""Cathepsin B"", ""Caspase-14"", ""Caspase-10"", ""Caspase-9"", ""Caspase-8"", ""Caspase-7"", ""Caspase-6"", ""Caspase-5"", ""Caspase-4"", ""Caspase-3"", ""Caspase-2"", ""Caspase-1"", ""Calpain 1"", ""Chymase"", ""Cathepsin G"", ""Dipeptidyl peptidase I"", ""Dipeptidyl peptidase IX"", ""Dipeptidyl peptidase VIII"", ""Dipeptidyl peptidase IV"")",1991,ELNE,Collagen degradation R-HSA-1442490 Degradation of the extracellular matrix R-HSA-1474228 Extracellular matrix organization R-HSA-1474244 Activation of Matrix Metalloproteinases R-HSA-1592389,12114510 GO:0005576 extracellular region NAS GO:0005576 extracellular region TAS 25645918 GO:0005615 extracellular space IDA 19506020 GO:0005737 cytoplasm IDA 12114510 GO:0009986 cell surface IDA 19506020 GO:0017053 transcriptional repressor complex IDA 11907569 GO:0030141 secretory granule IDA 19056867 23533145 GO:0070062 extracellular exosome IDA,IMP 19506020 negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA GO:0001878 response to yeast IBA GO:0002438 acute inflammatory response to antigenic stimulus IDA 11907569 proteolysis GO:0006508 NAS 15140022 cellular calcium ion homeostasis GO:0006874 IBA GO:0006909 phagocytosis IDA 11928814 response to UV GO:0009411 TAS GO:0022617 extracellular matrix disassembly NAS 12887060 protein catabolic process GO:0030163 IEA GO:0032496 response to lipopolysaccharide IDA 14705961 defense response to bacterium GO:0042742 NAS 14730209 positive regulation of MAP kinase activity GO:0043406 IEA GO:0044130 negative regulation of growth of symbiont in host IDA 12223522 negative regulation of chemokine biosynthetic process GO:0045079 IDA 12223522 negative regulation of interleukin-8 biosynthetic process GO:0045415 IDA 14730209 positive regulation of interleukin-8 biosynthetic process GO:0045416 IDA 15010259 positive regulation of smooth muscle cell proliferation GO:0048661 NAS 15140022 negative regulation of inflammatory response GO:0050728 IEA GO:0050778 positive regulation of immune response IEA GO:0050900 leukocyte migration NAS 15140022 negative regulation of chemotaxis GO:0050922 IEA GO:0070947 neutrophil mediated killing of fungus,19506020 IMP GO:0001106 RNA polymerase II transcription corepressor activity 6980881 IPI GO:0002020 protease binding 6980881 12887060 IDA GO:0004175 endopeptidase activity IBA GO:0004252 serine-type endopeptidase activity TAS GO:0004252 serine-type endopeptidase activity 12114510 12223522 14688365 19506020 21979170 IPI GO:0005515 protein binding 11907569 IDA GO:0008201 heparin binding 11907569 IDA GO:0008233 peptidase activity 12393522 IPI GO:0019955 cytokine binding,Transcriptional misregulation in cancer - Homo sapiens (human) hsa05202 Systemic lupus erythematosus - Homo sapiens (human) hsa05322,CHEMBL CHEMBL1819489,Q9NY91,Low affinity sodium-glucose cotransporter,1.0,ORTHOGONAL,NO,OC[C@H]1C[C@@H](Oc2ccccc2Cc3ccc(cc3)C4CC4)[C@H](O)[C@@H](O)[C@@H]1O,2,3,"InChI=1S/C23H28O5/c24-13-18-12-20(22(26)23(27)21(18)25)28-19-4-2-1-3-17(19)11-14-5-7-15(8-6-14)16-9-10-16/h1-8,16,18,20-27H,9-13H2/t18-,20-,21-,22+,23+/m1/s1",XCRLWQNVUFAWND-FXILAVBZSA-N,"c(""Low affinity sodium-glucose cotransporter"", ""Sodium/glucose cotransporter 1"", ""Unchecked"")",6527,SC5A4,"R-HSA-1430728 Metabolism R-HSA-189200 Hexose transport R-HSA-382551 Transmembrane transport of small molecules R-HSA-425366 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds R-HSA-425407 SLC-mediated transmembrane transport R-HSA-428808 Na+-dependent glucose transporters R-HSA-429593 Inositol transporters R-HSA-71387 Metabolism of carbohydrates",integral component of plasma membrane IBA GO:0005887,IBA GO:0006814 sodium ion transport IBA GO:1904659 glucose transmembrane transport,glucose:sodium symporter activity GO:0005412 IBA,,CHEMBL CHEMBL1770248,Q9NY91,Low affinity sodium-glucose cotransporter,1.0,PRIMARY,NO,CCOc1ccc(Cc2cc(ccc2Cl)[C@]34OC[C@](CO)(O3)[C@@H](O)[C@H](O)[C@H]4O)cc1,2,6,"InChI=1S/C22H25ClO7/c1-2-28-16-6-3-13(4-7-16)9-14-10-15(5-8-17(14)23)22-20(27)18(25)19(26)21(11-24,30-22)12-29-22/h3-8,10,18-20,24-27H,2,9,11-12H2,1H3/t18-,19-,20+,21-,22-/m0/s1",MCIACXAZCBVDEE-CUUWFGFTSA-N,"c(""Sodium/glucose cotransporter 1"", ""Low affinity sodium-glucose cotransporter"", ""Unchecked"")",6527,SC5A4,"R-HSA-1430728 Metabolism R-HSA-189200 Hexose transport R-HSA-382551 Transmembrane transport of small molecules R-HSA-425366 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds R-HSA-425407 SLC-mediated transmembrane transport R-HSA-428808 Na+-dependent glucose transporters R-HSA-429593 Inositol transporters R-HSA-71387 Metabolism of carbohydrates",integral component of plasma membrane IBA GO:0005887,IBA GO:0006814 sodium ion transport IBA GO:1904659 glucose transmembrane transport,glucose:sodium symporter activity GO:0005412 IBA,,CHEMBL CHEMBL603956,Q13133,LXR-alpha,1.0,PRIMARY,YES,CC(C)c1nc2c(Cl)cccn2c1c3cccc(Oc4cccc(c4)S(=O)(=O)C)c3,2,7,"InChI=1S/C23H21ClN2O3S/c1-15(2)21-22(26-12-6-11-20(24)23(26)25-21)16-7-4-8-17(13-16)29-18-9-5-10-19(14-18)30(3,27)28/h4-15H,1-3H3",NKFDLBSCCAQKKW-UHFFFAOYSA-N,"c(""LXR-alpha"", ""LXR-beta"", ""Liver X receptor (LXR alpha AND LXR beta)"")",10062,NR1H3,R-HSA-212436 Generic Transcription Pathway R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-74160 Gene Expression,GO:0000790 nuclear chromatin 18511497 IDA GO:0005634 nucleus 25661920 IDA GO:0005654 nucleoplasm TAS GO:0043235 receptor complex 18511497 IDA GO:0090575 RNA polymerase II transcription factor complex 18511497 IDA,"negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS transcription initiation from RNA polymerase II promoter GO:0006367 TAS negative regulation of macrophage derived foam cell differentiation GO:0010745 17693624 IC positive regulation of triglyceride biosynthetic process GO:0010867 17693624 IMP positive regulation of receptor biosynthetic process GO:0010870 18511497 IDA positive regulation of cholesterol efflux GO:0010875 16141411 IDA positive regulation of cholesterol efflux GO:0010875 17186944 IMP negative regulation of cholesterol storage GO:0010887 17693624 IMP intracellular receptor signaling pathway GO:0030522 IEA positive regulation of cellular protein metabolic process GO:0032270 17186944 IMP negative regulation of lipid transport GO:0032369 17693624 IMP positive regulation of cholesterol transport GO:0032376 16141411 IDA response to progesterone GO:0032570 16141411 IDA positive regulation of toll-like receptor 4 signaling pathway GO:0034145 18511497 IDA cholesterol homeostasis GO:0042632 ISS regulation of circadian rhythm GO:0042752 18511497 TAS negative regulation of macrophage activation GO:0043031 ISS apoptotic cell clearance GO:0043277 19628791 IMP steroid hormone mediated signaling pathway GO:0043401 IEA positive regulation of fatty acid biosynthetic process GO:0045723 17186944 IMP positive regulation of transcription, DNA-templated GO:0045893 25661920 IDA positive regulation of transcription, DNA-templated GO:0045893 19628791 IMP positive regulation of transcription from RNA polymerase II promoter GO:0045944 16141411 18511497 20219900 20837115 IDA positive regulation of transcription from RNA polymerase II promoter GO:0045944 17186944 19229075 IMP negative regulation of pinocytosis GO:0048550 17693624 IMP negative regulation of inflammatory response GO:0050728 ISS positive regulation of lipoprotein lipase activity GO:0051006 17186944 IMP lipid homeostasis GO:0055088 ISS sterol homeostasis GO:0055092 ISS negative regulation of interferon-gamma-mediated signaling pathway GO:0060336 21268089 NAS triglyceride homeostasis GO:0070328 ISS cellular response to lipopolysaccharide GO:0071222 18511497 IDA negative regulation of pancreatic juice secretion GO:0090188 ISS negative regulation of secretion of lysosomal enzymes GO:0090341 ISS regulation of cholesterol homeostasis GO:2000188 ISS positive regulation of cholesterol homeostasis GO:2000189 18511497 IDA","DNA binding 7744246 GO:0003677 TAS steroid hormone receptor activity GO:0003707 IEA transcription coactivator activity 7744246 GO:0003713 TAS RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding 7744246 GO:0004879 TAS protein binding 12040021 20219900 20682316 21516116 23455924 25416956 25661920 25962847 26120082 GO:0005515 IPI zinc ion binding GO:0008270 IEA cholesterol binding 11090131 GO:0015485 TAS sterol response element binding 19628791 GO:0032810 IDA sequence-specific DNA binding GO:0043565 IEA transcription regulatory region DNA binding 19229075 GO:0044212 IDA transcription regulatory region DNA binding contributes_to 18511497 GO:0044212 IDA",PPAR signaling pathway - Homo sapiens (human) hsa03320 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa04932 Hepatitis C - Homo sapiens (human) hsa05160,CHEMBL CHEMBL3134375,O60341,Lysine-specific histone demethylase 1,1.0,PRIMARY,NO,COc1ncccc1CNC2CC2c3ccccc3,2,3,"InChI=1S/C16H18N2O/c1-19-16-13(8-5-9-17-16)11-18-15-10-14(15)12-6-3-2-4-7-12/h2-9,14-15,18H,10-11H2,1H3",NPKNICGBPBZUFV-UHFFFAOYSA-N,"c(""Lysine-specific histone demethylase 1"", ""Monoamine oxidase A"")",23028,KDM1A,Hemostasis R-HSA-109582 Signal Transduction R-HSA-162582 Signaling by Rho GTPases R-HSA-194315 RHO GTPase Effectors R-HSA-195258 HDACs deacetylate histones R-HSA-3214815 HDMs demethylate histones R-HSA-3214842 Chromatin modifying enzymes R-HSA-3247509 Chromatin organization R-HSA-4839726 RHO GTPases activate PKNs R-HSA-5625740 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 R-HSA-5625886 Factors involved in megakaryocyte development and platelet production R-HSA-983231,"nuclear chromosome, telomeric region GO:0000784 IDA 24529708 nuclear chromatin GO:0000790 IDA 17277772 nuclear chromatin GO:0000790 ISS 20833138 nucleus GO:0005634 IDA 16079795 19497860 nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS transcription factor complex GO:0005667 ISS protein complex GO:0043234 IDA 24217620 DNA repair complex GO:1990391 IDA 24217620","negative regulation of transcription from RNA polymerase II promoter 17805299 GO:0000122 IMP negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISS in utero embryonic development GO:0001701 IEA transcription, DNA-templated GO:0006351 IEA regulation of transcription from RNA polymerase II promoter 16079795 GO:0006357 IMP protein demethylation 17805299 GO:0006482 IMP blood coagulation GO:0007596 TAS cell proliferation GO:0008283 IEA regulation of double-strand break repair via homologous recombination 24217620 GO:0010569 IMP regulation of primitive erythrocyte differentiation GO:0010725 IEA histone deacetylation GO:0016575 IEA pituitary gland development GO:0021983 IEA granulocyte differentiation GO:0030851 IEA negative regulation of protein binding 17805299 GO:0032091 IMP histone H3-K9 demethylation 16079795 20228790 GO:0033169 IDA positive regulation of histone ubiquitination 24217620 GO:0033184 IMP cellular response to UV 24217620 GO:0034644 IDA histone H3-K4 demethylation 15620353 20228790 24217620 GO:0034720 IDA negative regulation of DNA binding 17805299 GO:0043392 IC negative regulation of sequence-specific DNA binding transcription factor activity 19497860 GO:0043433 IDA negative regulation of sequence-specific DNA binding transcription factor activity 17805299 GO:0043433 IMP negative regulation of DNA damage response, signal transduction by p53 class mediator 17805299 GO:0043518 IMP positive regulation of erythrocyte differentiation GO:0045648 IEA positive regulation of megakaryocyte differentiation GO:0045654 IEA negative regulation of transcription, DNA-templated 19497860 GO:0045892 IDA positive regulation of transcription from RNA polymerase II promoter 20833138 GO:0045944 IDA positive regulation of hormone biosynthetic process GO:0046886 IEA positive regulation of sequence-specific DNA binding transcription factor activity 20833138 GO:0051091 IDA negative regulation of histone H3-K4 methylation GO:0051572 IEA negative regulation of histone H3-K9 methylation GO:0051573 IEA muscle cell development 20833138 GO:0055001 ISS oxidation-reduction process GO:0055114 IEA cellular response to gamma radiation 24217620 GO:0071480 IMP negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 17805299 GO:1902166 IMP regulation of cellular protein localization 24217620 GO:1903827 IMP positive regulation of neural precursor cell proliferation GO:2000179 IEA positive regulation of stem cell proliferation GO:2000648 IEA","GO:0001085 RNA polymerase II transcription factor binding IEA 17805299 GO:0002039 p53 binding IPI 16079795 20228790 24217620 GO:0003682 chromatin binding IDA GO:0003700 transcription factor activity, sequence-specific DNA binding IEA GO:0004407 histone deacetylase activity TAS 16169070 17537733 19497860 19703393 20228790 20389281 20448663 20562920 21258344 23455924 23592795 23752268 24529708 26226427 GO:0005515 protein binding IPI 20833138 GO:0008134 transcription factor binding IDA 15620353 GO:0016491 oxidoreductase activity IDA 17277772 GO:0019899 enzyme binding IPI 16079795 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IMP 17805299 GO:0032451 demethylase activity IMP 16079795 18066052 GO:0032452 histone demethylase activity EXP 19497860 GO:0032452 histone demethylase activity IDA GO:0032452 histone demethylase activity TAS 15620353 GO:0032453 histone demethylase activity (H3-K4 specific) IDA 16079795 20228790 GO:0032454 histone demethylase activity (H3-K9 specific) IDA 20228790 GO:0034648 histone demethylase activity (H3-dimethyl-K4 specific) IDA 24529708 GO:0042162 telomeric DNA binding IMP 20833138 GO:0043426 MRF binding IDA GO:0044212 transcription regulatory region DNA binding ISS 15620353 GO:0050660 flavin adenine dinucleotide binding IDA 16079795 GO:0050681 androgen receptor binding IDA 24529708 GO:0061752 telomeric repeat-containing RNA binding IDA",,CHEMBL CHEMBL2182052,Q92633,Lysophosphatidic acid receptor Edg-2,1.0,PRIMARY,NO,C[C@@H](OC(=O)Nc1c(C)noc1c2ccc(cc2)c3ccc(CC(=O)O)cc3)c4ccccc4,5,6,"InChI=1S/C27H24N2O5/c1-17-25(28-27(32)33-18(2)20-6-4-3-5-7-20)26(34-29-17)23-14-12-22(13-15-23)21-10-8-19(9-11-21)16-24(30)31/h3-15,18H,16H2,1-2H3,(H,28,32)(H,30,31)/t18-/m1/s1",LNDDRUPAICPXIN-GOSISDBHSA-N,"c(""Lysophosphatidic acid receptor Edg-2"", ""Lysophosphatidic acid receptor Edg-7"", ""Lysophosphatidic acid receptor Edg-4"", ""Lysophosphatidic acid receptor 4"", ""Lysophosphatidic acid receptor 5"")",1902,LPAR1,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-418594 G alpha (i) signalling events R-HSA-419408 Lysosphingolipid and LPA receptors R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,IDA 19306925 endosome GO:0005768 IDA 19306925 plasma membrane GO:0005886 TAS GO:0005886 plasma membrane ISS GO:0005887 integral component of plasma membrane IDA 19306925 cell surface GO:0009986 IDA colocalizes_with 19306925 endocytic vesicle GO:0030139 IEA GO:0043025 neuronal cell body IEA GO:0043197 dendritic spine IEA GO:0043198 dendritic shaft,GO:0000187 activation of MAPK activity IEA 8922387 GO:0007186 G-protein coupled receptor signaling pathway TAS GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ISS 19306925 GO:0007202 activation of phospholipase C activity IDA 9804623 GO:0007204 positive regulation of cytosolic calcium ion concentration TAS GO:0008360 regulation of cell shape ISS GO:0010977 negative regulation of neuron projection development ISS GO:0014003 oligodendrocyte development IEA GO:0021549 cerebellum development IEA GO:0021554 optic nerve development IEA GO:0022038 corpus callosum development IEA GO:0030818 negative regulation of cAMP biosynthetic process IEA GO:0032060 bleb assembly IEA GO:0035025 positive regulation of Rho protein signal transduction ISS GO:0042552 myelination IEA GO:0043065 positive regulation of apoptotic process IEA 12761501 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP GO:0043410 positive regulation of MAPK cascade ISS 19733258 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IMP GO:0051496 positive regulation of stress fiber assembly ISS 19733258 GO:0060326 cell chemotaxis IMP GO:0060999 positive regulation of dendritic spine development IEA GO:0071453 cellular response to oxygen levels IEA GO:0071673 positive regulation of smooth muscle cell chemotaxis IEA GO:1904566 cellular response to 1-oleoyl-sn-glycerol 3-phosphate IEA,G-protein alpha-subunit binding IEA GO:0001965 G-protein coupled receptor activity TAS 8922387 GO:0004930 protein binding IPI 19306925 GO:0005515 PDZ domain binding IEA GO:0030165 lysophosphatidic acid binding IDA 9070858 GO:0035727 lysophosphatidic acid receptor activity IDA 19306925 GO:0070915 lysophosphatidic acid receptor activity IMP 9070858 GO:0070915,hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04540 Gap junction - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human),CHEMBL CHEMBL202361,Q9UBY5,Lysophosphatidic acid receptor Edg-7,1.0,PRIMARY,NO,CCCCCCCC(=O)OC[C@H](COP(=S)(O)O)OC(=O)CCCCCCC,4,4,"InChI=1S/C19H37O7PS/c1-3-5-7-9-11-13-18(20)24-15-17(16-25-27(22,23)28)26-19(21)14-12-10-8-6-4-2/h17H,3-16H2,1-2H3,(H2,22,23,28)/t17-/m1/s1",CUXSKJSPPDINEH-QGZVFWFLSA-N,"c(""Lysophosphatidic acid receptor Edg-2"", ""Lysophosphatidic acid receptor Edg-4"", ""Lysophosphatidic acid receptor Edg-7"", ""Autotaxin"")",23566,LPAR3,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 G alpha (i) signalling events R-HSA-418594 Lysosphingolipid and LPA receptors R-HSA-419408 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,IEA GO:0005829 cytosol TAS GO:0005886 plasma membrane 10488122 TAS GO:0005887 integral component of plasma membrane IEA GO:0030424 axon,"activation of MAPK activity IEA GO:0000187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 10488122 GO:0007187 positive regulation of cytosolic calcium ion concentration TAS 10488122 GO:0007204 chemical synaptic transmission TAS 10488122 GO:0007268 bleb assembly IEA GO:0032060 positive regulation of collateral sprouting IEA GO:0048672 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA GO:0051482 positive regulation of calcium ion transport IEA GO:0051928",GO:0001965 G-protein alpha-subunit binding IEA GO:0004930 G-protein coupled receptor activity 10488122 TAS GO:0005543 phospholipid binding IEA GO:0008289 lipid binding 10488122 TAS GO:0070915 lysophosphatidic acid receptor activity IEA,Rap1 signaling pathway - Homo sapiens (human) hsa04015 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Pathways in cancer - Homo sapiens (human) hsa05200,CHEMBL CHEMBL201482,Q9UBY5,Lysophosphatidic acid receptor Edg-7,1.0,PRIMARY,YES,CCCCCCCCOC[C@H](COP(=S)(O)O)OCCCCCCCC,3,3,"InChI=1S/C19H41O5PS/c1-3-5-7-9-11-13-15-22-17-19(18-24-25(20,21)26)23-16-14-12-10-8-6-4-2/h19H,3-18H2,1-2H3,(H2,20,21,26)/t19-/m1/s1",PLCCQSPJUXGEHV-LJQANCHMSA-N,"c(""Lysophosphatidic acid receptor Edg-2"", ""Lysophosphatidic acid receptor Edg-4"", ""Lysophosphatidic acid receptor Edg-7"")",23566,LPAR3,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 G alpha (i) signalling events R-HSA-418594 Lysosphingolipid and LPA receptors R-HSA-419408 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,IEA GO:0005829 cytosol TAS GO:0005886 plasma membrane 10488122 TAS GO:0005887 integral component of plasma membrane IEA GO:0030424 axon,"activation of MAPK activity IEA GO:0000187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 10488122 GO:0007187 positive regulation of cytosolic calcium ion concentration TAS 10488122 GO:0007204 chemical synaptic transmission TAS 10488122 GO:0007268 bleb assembly IEA GO:0032060 positive regulation of collateral sprouting IEA GO:0048672 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA GO:0051482 positive regulation of calcium ion transport IEA GO:0051928",GO:0001965 G-protein alpha-subunit binding IEA GO:0004930 G-protein coupled receptor activity 10488122 TAS GO:0005543 phospholipid binding IEA GO:0008289 lipid binding 10488122 TAS GO:0070915 lysophosphatidic acid receptor activity IEA,Rap1 signaling pathway - Homo sapiens (human) hsa04015 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Pathways in cancer - Homo sapiens (human) hsa05200,CHEMBL CHEMBL1614995,P49137,MAP kinase-activated protein kinase 2,1.0,PRIMARY,NO,COCCOc1cncc(c1)c2cc3c(ccc4c5C(=O)NCCc5[nH]c34)cn2,2,8,"InChI=1S/C22H20N4O3/c1-28-6-7-29-15-8-14(10-23-12-15)19-9-17-13(11-25-19)2-3-16-20-18(26-21(16)17)4-5-24-22(20)27/h2-3,8-12,26H,4-7H2,1H3,(H,24,27)",ZYTDQGRQFPNBGA-UHFFFAOYSA-N,"c(""MAP kinase-activated protein kinase 2"", ""PBMC"", ""c-Jun N-terminal kinase 2"", ""Unchecked"")",9261,MAPK2,Metabolism R-HSA-1430728 Signal Transduction R-HSA-162582 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 Activated TLR4 signalling R-HSA-166054 MyD88:Mal cascade initiated on plasma membrane R-HSA-166058 MyD88-independent TLR3/TLR4 cascade R-HSA-166166 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168180 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Toll-Like Receptors Cascades R-HSA-168898 p38MAPK events R-HSA-171007 Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signaling by VEGF R-HSA-194138 Nuclear Events (kinase and transcription factor activation) R-HSA-198725 CREB phosphorylation R-HSA-199920 Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 Arachidonic acid metabolism R-HSA-2142753 Cellular responses to stress R-HSA-2262752 Oxidative Stress Induced Senescence R-HSA-2559580 Cellular Senescence R-HSA-2559583 Regulation of HSF1-mediated heat shock response R-HSA-3371453 Cellular response to heat stress R-HSA-3371556 VEGFA-VEGFR2 Pathway R-HSA-4420097 MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450282 MAP kinase activation in TLR cascade R-HSA-450294 activated TAK1 mediates p38 MAPK activation R-HSA-450302 Butyrate Response Factor 1 (BRF1) destabilizes mRNA R-HSA-450385 Tristetraprolin (TTP) destabilizes mRNA R-HSA-450513 Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-450531 Metabolism of lipids and lipoproteins R-HSA-556833 Gene Expression R-HSA-74160 TRIF-mediated TLR3/TLR4 signaling R-HSA-937061 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 MyD88 dependent cascade initiated on endosome R-HSA-975155 MyD88 cascade initiated on plasma membrane R-HSA-975871,nucleus 20932473 GO:0005634 IDA nucleoplasm GO:0005654 IDA nucleoplasm GO:0005654 TAS cytoplasm 20932473 GO:0005737 IDA centrosome GO:0005813 IDA cytosol GO:0005829 TAS extracellular exosome 18570454 GO:0070062 IDA,GO:0000165 MAPK cascade 8179591 TAS GO:0000187 activation of MAPK activity TAS GO:0002224 toll-like receptor signaling pathway ISS GO:0006468 protein phosphorylation 8179591 TAS GO:0006691 leukotriene metabolic process TAS GO:0006950 response to stress 15014438 IDA GO:0006954 inflammatory response IBA GO:0006954 inflammatory response ISS GO:0006974 cellular response to DNA damage stimulus 20932473 IMP GO:0007265 Ras protein signal transduction TAS GO:0018105 peptidyl-serine phosphorylation 15850461 IDA GO:0031572 G2 DNA damage checkpoint 20932473 IMP GO:0032496 response to lipopolysaccharide ISS GO:0032675 regulation of interleukin-6 production ISS GO:0032680 regulation of tumor necrosis factor production 15014438 IDA GO:0034097 response to cytokine 8774846 IDA GO:0035924 cellular response to vascular endothelial growth factor stimulus 18440775 IMP GO:0038066 p38MAPK cascade IEA GO:0042535 positive regulation of tumor necrosis factor biosynthetic process IEA GO:0043488 regulation of mRNA stability TAS GO:0044351 macropinocytosis ISS GO:0046777 protein autophosphorylation IBA GO:0048010 vascular endothelial growth factor receptor signaling pathway 18440775 IMP GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS GO:0048839 inner ear development IEA GO:0070935 3'-UTR-mediated mRNA stabilization 14517288 15014438 20932473 IDA GO:1900034 regulation of cellular response to heat TAS,protein kinase activity GO:0004672 TAS 8179591 protein serine/threonine kinase activity GO:0004674 EXP 7799959 16278218 protein serine/threonine kinase activity GO:0004674 IDA 2402373 8774846 8846784 14517288 15014438 15850461 20932473 protein serine/threonine kinase activity GO:0004674 TAS calmodulin-dependent protein kinase activity GO:0004683 IBA signal transducer activity GO:0004871 TAS 8179591 protein binding GO:0005515 IPI 8774846 14517288 15014438 16278218 17255097 19369945 20932473 21575178 21988832 23455922 23602568 25241761 25852190 26496610 calmodulin binding GO:0005516 IBA ATP binding GO:0005524 IEA calcium-dependent protein serine/threonine kinase activity GO:0009931 IBA,hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04370 VEGF signaling pathway - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human),CHEMBL CHEMBL3590121,P28482,MAP kinase ERK2,1.0,ORTHOGONAL,NO,FC(F)(F)c1cnc(NC2CCOCC2)nc1Nc3ccccc3NC(=O)C=C,2,12,"InChI=1S/C19H20F3N5O2/c1-2-16(28)25-14-5-3-4-6-15(14)26-17-13(19(20,21)22)11-23-18(27-17)24-12-7-9-29-10-8-12/h2-6,11-12H,1,7-10H2,(H,25,28)(H2,23,24,26,27)",COSHZQYMYFJMAZ-UHFFFAOYSA-N,"c(""MAP kinase ERK2"", ""Unchecked"", ""A375"", ""Dual specificity mitogen-activated protein kinase kinase 1"")",5594,MK01,"R-HSA-109582 Hemostasis R-HSA-111885 Opioid Signalling R-HSA-111995 phospho-PLA2 pathway R-HSA-111996 Ca-dependent events R-HSA-112040 G-protein mediated events R-HSA-112043 PLC beta mediated events R-HSA-112314 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System R-HSA-112399 IRS-mediated signalling R-HSA-112409 RAF-independent MAPK1/3 activation R-HSA-112411 MAPK1 (ERK2) activation R-HSA-112412 SOS-mediated signalling R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250196 SHC1 events in ERBB2 signaling R-HSA-1250347 SHC1 events in ERBB4 signaling R-HSA-1266738 Developmental Biology R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1433557 Signaling by SCF-KIT R-HSA-162582 Signal Transduction R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-1640170 Cell Cycle R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166054 Activated TLR4 signalling R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-166166 MyD88-independent TLR3/TLR4 cascade R-HSA-166520 Signalling by NGF R-HSA-167044 Signalling to RAS R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168180 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-168898 Toll-Like Receptors Cascades R-HSA-169893 Prolonged ERK activation events R-HSA-170968 Frs2-mediated activation R-HSA-170984 ARMS-mediated activation R-HSA-177929 Signaling by EGFR R-HSA-179812 GRB2 events in EGFR signaling R-HSA-180336 SHC1 events in EGFR signaling R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-187687 Signalling to ERKs R-HSA-187706 Signalling to p38 via RIT and RIN R-HSA-190236 Signaling by FGFR R-HSA-194138 Signaling by VEGF R-HSA-194315 Signaling by Rho GTPases R-HSA-195258 RHO GTPase Effectors R-HSA-1963640 GRB2 events in ERBB2 signaling R-HSA-198725 Nuclear Events (kinase and transcription factor activation) R-HSA-198753 ERK/MAPK targets R-HSA-202670 ERKs are inactivated R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-2172127 DAP12 interactions R-HSA-2262752 Cellular responses to stress R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559583 Cellular Senescence R-HSA-2559585 Oncogene Induced Senescence R-HSA-2586552 Signaling by Leptin R-HSA-2871796 FCERI mediated MAPK activation R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-3371556 Cellular response to heat stress R-HSA-372790 Signaling by GPCR R-HSA-373760 L1CAM interactions R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-422475 Axon guidance R-HSA-437239 Recycling pathway of L1 R-HSA-438064 Post NMDA receptor activation events R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-442742 CREB phosphorylation through the activation of Ras R-HSA-442755 Activation of NMDA receptor upon glutamate binding and postsynaptic events R-HSA-444257 RSK activation R-HSA-445144 Signal transduction by L1 R-HSA-449147 Signaling by Interleukins R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450294 MAP kinase activation in TLR cascade R-HSA-450341 Activation of the AP-1 family of transcription factors R-HSA-451927 Interleukin-2 signaling R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654726 Negative regulation of FGFR1 signaling R-HSA-5654727 Negative regulation of FGFR2 signaling R-HSA-5654732 Negative regulation of FGFR3 signaling R-HSA-5654733 Negative regulation of FGFR4 signaling R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5674135 MAP2K and MAPK activation R-HSA-5674499 Negative feedback regulation of MAPK pathway R-HSA-5675221 Negative regulation of MAPK pathway R-HSA-5683057 MAPK family signaling cascades R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-68875 Mitotic Prophase R-HSA-68886 M Phase R-HSA-69278 Cell Cycle, Mitotic R-HSA-74749 Signal attenuation R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-879415 Advanced glycosylation endproduct receptor signaling R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-912526 Interleukin receptor SHC signaling R-HSA-937061 TRIF-mediated TLR3/TLR4 signaling R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-975871 MyD88 cascade initiated on plasma membrane",IDA 16791210 18794356 nucleus GO:0005634 TAS 19565474 nucleus GO:0005634 IDA GO:0005654 nucleoplasm TAS GO:0005654 nucleoplasm IDA 16791210 18794356 cytoplasm GO:0005737 ISS GO:0005737 cytoplasm TAS 19565474 mitochondrion GO:0005739 TAS 19565474 early endosome GO:0005769 TAS 19565474 late endosome GO:0005770 TAS 19565474 Golgi apparatus GO:0005794 IEA GO:0005815 microtubule organizing center TAS 19565474 cytosol GO:0005829 TAS 19565474 cytoskeleton GO:0005856 TAS 19565474 caveola GO:0005901 TAS 19565474 focal adhesion GO:0005925 IDA GO:0015630 microtubule cytoskeleton IEA GO:0030424 axon IEA GO:0031143 pseudopodium IEA GO:0032839 dendrite cytoplasm IEA GO:0043204 perikaryon IEA GO:0043234 protein complex IDA 23376485 extracellular exosome GO:0070062 ISS GO:0072686 mitotic spindle,"MAPK cascade GO:0000165 TAS activation of MAPK activity GO:0000187 TAS MAPK import into nucleus GO:0000189 IEA transcription, DNA-templated GO:0006351 IEA protein phosphorylation GO:0006468 23184662 IDA apoptotic process GO:0006915 IEA chemotaxis GO:0006935 10706854 TAS response to stress GO:0006950 10958679 TAS cellular response to DNA damage stimulus GO:0006974 IEA cell cycle GO:0007049 IEA signal transduction GO:0007165 1540184 TAS chemical synaptic transmission GO:0007268 10051431 TAS axon guidance GO:0007411 TAS positive regulation of cell proliferation GO:0008284 IEA fibroblast growth factor receptor signaling pathway GO:0008543 TAS response to toxic substance GO:0009636 IEA positive regulation of peptidyl-threonine phosphorylation GO:0010800 16314496 IDA regulation of phosphatidylinositol 3-kinase signaling GO:0014066 TAS viral process GO:0016032 IEA peptidyl-serine phosphorylation GO:0018105 15850461 IDA peptidyl-threonine phosphorylation GO:0018107 ISS sensory perception of pain GO:0019233 IEA cytosine metabolic process GO:0019858 IEA platelet activation GO:0030168 TAS positive regulation of cell migration GO:0030335 IEA thyroid gland development GO:0030878 IEA regulation of protein stability GO:0031647 ISS lipopolysaccharide-mediated signaling pathway GO:0031663 IEA positive regulation of telomere maintenance via telomerase GO:0032212 21531765 IMP regulation of stress-activated MAPK cascade GO:0032872 19565474 TAS mammary gland epithelial cell proliferation GO:0033598 IEA Fc-epsilon receptor signaling pathway GO:0038095 TAS Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS ERBB signaling pathway GO:0038127 15133037 IDA outer ear morphogenesis GO:0042473 IEA response to exogenous dsRNA GO:0043330 IEA response to estrogen GO:0043627 IEA negative regulation of cell differentiation GO:0045596 IEA positive regulation of translation GO:0045727 IEA positive regulation of transcription, DNA-templated GO:0045893 IEA thymus development GO:0048538 IEA T cell receptor signaling pathway GO:0050852 IEA B cell receptor signaling pathway GO:0050853 IEA regulation of sequence-specific DNA binding transcription factor activity GO:0051090 TAS regulation of cytoskeleton organization GO:0051493 19565474 TAS positive regulation of telomerase activity GO:0051973 21531765 IMP Bergmann glial cell differentiation GO:0060020 IEA long-term synaptic potentiation GO:0060291 IEA face development GO:0060324 IEA JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 TAS lung morphogenesis GO:0060425 IEA trachea formation GO:0060440 IEA labyrinthine layer blood vessel development GO:0060716 IEA cardiac neural crest cell development involved in heart development GO:0061308 IEA ERK1 and ERK2 cascade GO:0070371 16314496 IDA ERK1 and ERK2 cascade GO:0070371 TAS response to epidermal growth factor GO:0070849 18794356 IDA caveolin-mediated endocytosis GO:0072584 19565474 TAS regulation of Golgi inheritance GO:0090170 19565474 TAS cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 IEA regulation of cellular response to heat GO:1900034 TAS positive regulation of telomere capping GO:1904355 21531765 IMP regulation of early endosome to late endosome transport GO:2000641 19565474 TAS",GO:0001784 phosphotyrosine binding IEA GO:0003677 DNA binding IEA 15850461 18794356 GO:0004674 protein serine/threonine kinase activity IDA GO:0004674 protein serine/threonine kinase activity TAS GO:0004707 MAP kinase activity TAS 8626452 9632734 10415025 10601328 12592337 15133037 15713638 16286470 16288922 17255944 17255949 17620599 18616943 18794356 19494114 19892016 21988832 22253824 22521293 23241949 23397142 23560844 23602568 23847209 24735981 25241761 26267535 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0008134 transcription factor binding IEA GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity ISS GO:0016301 kinase activity TAS 19494114 GO:0019902 phosphatase binding IPI GO:0031435 mitogen-activated protein kinase kinase kinase binding IEA 26267534 GO:0042802 identical protein binding IPI,"hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04071 Sphingolipid signaling pathway - Homo sapiens (human) hsa04114 Oocyte meiosis - Homo sapiens (human) hsa04150 mTOR signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) hsa04320 Dorso-ventral axis formation - Homo sapiens (human) hsa04350 TGF-beta signaling pathway - Homo sapiens (human) hsa04360 Axon guidance - Homo sapiens (human) hsa04370 VEGF signaling pathway - Homo sapiens (human) hsa04380 Osteoclast differentiation - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04520 Adherens junction - Homo sapiens (human) hsa04540 Gap junction - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04611 Platelet activation - Homo sapiens (human) hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human) hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04660 T cell receptor signaling pathway - Homo sapiens (human) hsa04662 B cell receptor signaling pathway - Homo sapiens (human) hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04668 TNF signaling pathway - Homo sapiens (human) hsa04713 Circadian entrainment - Homo sapiens (human) hsa04720 Long-term potentiation - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04724 Glutamatergic synapse - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human) hsa04726 Serotonergic synapse - Homo sapiens (human) hsa04730 Long-term depression - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04910 Insulin signaling pathway - Homo sapiens (human) hsa04912 GnRH signaling pathway - Homo sapiens (human) hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04915 Estrogen signaling pathway - Homo sapiens (human) hsa04916 Melanogenesis - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04921 Oxytocin signaling pathway - Homo sapiens (human) hsa04930 Type II diabetes mellitus - Homo sapiens (human) hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) hsa05010 Alzheimer,s disease - Homo sapiens (human) hsa05020 Prion diseases - Homo sapiens (human) hsa05034 Alcoholism - Homo sapiens (human) hsa05131 Shigellosis - Homo sapiens (human) hsa05132 Salmonella infection - Homo sapiens (human) hsa05133 Pertussis - Homo sapiens (human) hsa05140 Leishmaniasis - Homo sapiens (human) hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05152 Tuberculosis - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human) hsa05161 Hepatitis B - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05210 Colorectal cancer - Homo sapiens (human) hsa05211 Renal cell carcinoma - Homo sapiens (human) hsa05212 Pancreatic cancer - Homo sapiens (human) hsa05213 Endometrial cancer - Homo sapiens (human) hsa05214 Glioma - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05216 Thyroid cancer - Homo sapiens (human) hsa05218 Melanoma - Homo sapiens (human) hsa05219 Bladder cancer - Homo sapiens (human) hsa05220 Chronic myeloid leukemia - Homo sapiens (human) hsa05221 Acute myeloid leukemia - Homo sapiens (human) hsa05223 Non-small cell lung cancer - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human) hsa05231 Choline metabolism in cancer - Homo sapiens (human)",CHEMBL CHEMBL3590110,P28482,MAP kinase ERK2,1.0,PRIMARY,NO,C=CS(=O)(=O)Nc1ccc2[nH]nc(c3ccncc3)c2c1,2,14,"InChI=1S/C14H12N4O2S/c1-2-21(19,20)18-11-3-4-13-12(9-11)14(17-16-13)10-5-7-15-8-6-10/h2-9,18H,1H2,(H,16,17)",MIISUCGGVANLKC-UHFFFAOYSA-N,"c(""MAP kinase ERK2"", ""Unchecked"", ""A375"", ""Dual specificity mitogen-activated protein kinase kinase 1"")",5594,MK01,"R-HSA-109582 Hemostasis R-HSA-111885 Opioid Signalling R-HSA-111995 phospho-PLA2 pathway R-HSA-111996 Ca-dependent events R-HSA-112040 G-protein mediated events R-HSA-112043 PLC beta mediated events R-HSA-112314 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System R-HSA-112399 IRS-mediated signalling R-HSA-112409 RAF-independent MAPK1/3 activation R-HSA-112411 MAPK1 (ERK2) activation R-HSA-112412 SOS-mediated signalling R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250196 SHC1 events in ERBB2 signaling R-HSA-1250347 SHC1 events in ERBB4 signaling R-HSA-1266738 Developmental Biology R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1433557 Signaling by SCF-KIT R-HSA-162582 Signal Transduction R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-1640170 Cell Cycle R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166054 Activated TLR4 signalling R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-166166 MyD88-independent TLR3/TLR4 cascade R-HSA-166520 Signalling by NGF R-HSA-167044 Signalling to RAS R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168180 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-168898 Toll-Like Receptors Cascades R-HSA-169893 Prolonged ERK activation events R-HSA-170968 Frs2-mediated activation R-HSA-170984 ARMS-mediated activation R-HSA-177929 Signaling by EGFR R-HSA-179812 GRB2 events in EGFR signaling R-HSA-180336 SHC1 events in EGFR signaling R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-187687 Signalling to ERKs R-HSA-187706 Signalling to p38 via RIT and RIN R-HSA-190236 Signaling by FGFR R-HSA-194138 Signaling by VEGF R-HSA-194315 Signaling by Rho GTPases R-HSA-195258 RHO GTPase Effectors R-HSA-1963640 GRB2 events in ERBB2 signaling R-HSA-198725 Nuclear Events (kinase and transcription factor activation) R-HSA-198753 ERK/MAPK targets R-HSA-202670 ERKs are inactivated R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation R-HSA-2172127 DAP12 interactions R-HSA-2262752 Cellular responses to stress R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559583 Cellular Senescence R-HSA-2559585 Oncogene Induced Senescence R-HSA-2586552 Signaling by Leptin R-HSA-2871796 FCERI mediated MAPK activation R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-3371556 Cellular response to heat stress R-HSA-372790 Signaling by GPCR R-HSA-373760 L1CAM interactions R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-422475 Axon guidance R-HSA-437239 Recycling pathway of L1 R-HSA-438064 Post NMDA receptor activation events R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-442742 CREB phosphorylation through the activation of Ras R-HSA-442755 Activation of NMDA receptor upon glutamate binding and postsynaptic events R-HSA-444257 RSK activation R-HSA-445144 Signal transduction by L1 R-HSA-449147 Signaling by Interleukins R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450294 MAP kinase activation in TLR cascade R-HSA-450341 Activation of the AP-1 family of transcription factors R-HSA-451927 Interleukin-2 signaling R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654726 Negative regulation of FGFR1 signaling R-HSA-5654727 Negative regulation of FGFR2 signaling R-HSA-5654732 Negative regulation of FGFR3 signaling R-HSA-5654733 Negative regulation of FGFR4 signaling R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5674135 MAP2K and MAPK activation R-HSA-5674499 Negative feedback regulation of MAPK pathway R-HSA-5675221 Negative regulation of MAPK pathway R-HSA-5683057 MAPK family signaling cascades R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-68875 Mitotic Prophase R-HSA-68886 M Phase R-HSA-69278 Cell Cycle, Mitotic R-HSA-74749 Signal attenuation R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-879415 Advanced glycosylation endproduct receptor signaling R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-912526 Interleukin receptor SHC signaling R-HSA-937061 TRIF-mediated TLR3/TLR4 signaling R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-975871 MyD88 cascade initiated on plasma membrane",IDA 16791210 18794356 nucleus GO:0005634 TAS 19565474 nucleus GO:0005634 IDA GO:0005654 nucleoplasm TAS GO:0005654 nucleoplasm IDA 16791210 18794356 cytoplasm GO:0005737 ISS GO:0005737 cytoplasm TAS 19565474 mitochondrion GO:0005739 TAS 19565474 early endosome GO:0005769 TAS 19565474 late endosome GO:0005770 TAS 19565474 Golgi apparatus GO:0005794 IEA GO:0005815 microtubule organizing center TAS 19565474 cytosol GO:0005829 TAS 19565474 cytoskeleton GO:0005856 TAS 19565474 caveola GO:0005901 TAS 19565474 focal adhesion GO:0005925 IDA GO:0015630 microtubule cytoskeleton IEA GO:0030424 axon IEA GO:0031143 pseudopodium IEA GO:0032839 dendrite cytoplasm IEA GO:0043204 perikaryon IEA GO:0043234 protein complex IDA 23376485 extracellular exosome GO:0070062 ISS GO:0072686 mitotic spindle,"MAPK cascade GO:0000165 TAS activation of MAPK activity GO:0000187 TAS MAPK import into nucleus GO:0000189 IEA transcription, DNA-templated GO:0006351 IEA protein phosphorylation GO:0006468 23184662 IDA apoptotic process GO:0006915 IEA chemotaxis GO:0006935 10706854 TAS response to stress GO:0006950 10958679 TAS cellular response to DNA damage stimulus GO:0006974 IEA cell cycle GO:0007049 IEA signal transduction GO:0007165 1540184 TAS chemical synaptic transmission GO:0007268 10051431 TAS axon guidance GO:0007411 TAS positive regulation of cell proliferation GO:0008284 IEA fibroblast growth factor receptor signaling pathway GO:0008543 TAS response to toxic substance GO:0009636 IEA positive regulation of peptidyl-threonine phosphorylation GO:0010800 16314496 IDA regulation of phosphatidylinositol 3-kinase signaling GO:0014066 TAS viral process GO:0016032 IEA peptidyl-serine phosphorylation GO:0018105 15850461 IDA peptidyl-threonine phosphorylation GO:0018107 ISS sensory perception of pain GO:0019233 IEA cytosine metabolic process GO:0019858 IEA platelet activation GO:0030168 TAS positive regulation of cell migration GO:0030335 IEA thyroid gland development GO:0030878 IEA regulation of protein stability GO:0031647 ISS lipopolysaccharide-mediated signaling pathway GO:0031663 IEA positive regulation of telomere maintenance via telomerase GO:0032212 21531765 IMP regulation of stress-activated MAPK cascade GO:0032872 19565474 TAS mammary gland epithelial cell proliferation GO:0033598 IEA Fc-epsilon receptor signaling pathway GO:0038095 TAS Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS ERBB signaling pathway GO:0038127 15133037 IDA outer ear morphogenesis GO:0042473 IEA response to exogenous dsRNA GO:0043330 IEA response to estrogen GO:0043627 IEA negative regulation of cell differentiation GO:0045596 IEA positive regulation of translation GO:0045727 IEA positive regulation of transcription, DNA-templated GO:0045893 IEA thymus development GO:0048538 IEA T cell receptor signaling pathway GO:0050852 IEA B cell receptor signaling pathway GO:0050853 IEA regulation of sequence-specific DNA binding transcription factor activity GO:0051090 TAS regulation of cytoskeleton organization GO:0051493 19565474 TAS positive regulation of telomerase activity GO:0051973 21531765 IMP Bergmann glial cell differentiation GO:0060020 IEA long-term synaptic potentiation GO:0060291 IEA face development GO:0060324 IEA JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 TAS lung morphogenesis GO:0060425 IEA trachea formation GO:0060440 IEA labyrinthine layer blood vessel development GO:0060716 IEA cardiac neural crest cell development involved in heart development GO:0061308 IEA ERK1 and ERK2 cascade GO:0070371 16314496 IDA ERK1 and ERK2 cascade GO:0070371 TAS response to epidermal growth factor GO:0070849 18794356 IDA caveolin-mediated endocytosis GO:0072584 19565474 TAS regulation of Golgi inheritance GO:0090170 19565474 TAS cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 IEA regulation of cellular response to heat GO:1900034 TAS positive regulation of telomere capping GO:1904355 21531765 IMP regulation of early endosome to late endosome transport GO:2000641 19565474 TAS",GO:0001784 phosphotyrosine binding IEA GO:0003677 DNA binding IEA 15850461 18794356 GO:0004674 protein serine/threonine kinase activity IDA GO:0004674 protein serine/threonine kinase activity TAS GO:0004707 MAP kinase activity TAS 8626452 9632734 10415025 10601328 12592337 15133037 15713638 16286470 16288922 17255944 17255949 17620599 18616943 18794356 19494114 19892016 21988832 22253824 22521293 23241949 23397142 23560844 23602568 23847209 24735981 25241761 26267535 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0008134 transcription factor binding IEA GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity ISS GO:0016301 kinase activity TAS 19494114 GO:0019902 phosphatase binding IPI GO:0031435 mitogen-activated protein kinase kinase kinase binding IEA 26267534 GO:0042802 identical protein binding IPI,"hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04071 Sphingolipid signaling pathway - Homo sapiens (human) hsa04114 Oocyte meiosis - Homo sapiens (human) hsa04150 mTOR signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) hsa04320 Dorso-ventral axis formation - Homo sapiens (human) hsa04350 TGF-beta signaling pathway - Homo sapiens (human) hsa04360 Axon guidance - Homo sapiens (human) hsa04370 VEGF signaling pathway - Homo sapiens (human) hsa04380 Osteoclast differentiation - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04520 Adherens junction - Homo sapiens (human) hsa04540 Gap junction - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04611 Platelet activation - Homo sapiens (human) hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human) hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04660 T cell receptor signaling pathway - Homo sapiens (human) hsa04662 B cell receptor signaling pathway - Homo sapiens (human) hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04668 TNF signaling pathway - Homo sapiens (human) hsa04713 Circadian entrainment - Homo sapiens (human) hsa04720 Long-term potentiation - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04724 Glutamatergic synapse - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human) hsa04726 Serotonergic synapse - Homo sapiens (human) hsa04730 Long-term depression - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04910 Insulin signaling pathway - Homo sapiens (human) hsa04912 GnRH signaling pathway - Homo sapiens (human) hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04915 Estrogen signaling pathway - Homo sapiens (human) hsa04916 Melanogenesis - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04921 Oxytocin signaling pathway - Homo sapiens (human) hsa04930 Type II diabetes mellitus - Homo sapiens (human) hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) hsa05010 Alzheimer,s disease - Homo sapiens (human) hsa05020 Prion diseases - Homo sapiens (human) hsa05034 Alcoholism - Homo sapiens (human) hsa05131 Shigellosis - Homo sapiens (human) hsa05132 Salmonella infection - Homo sapiens (human) hsa05133 Pertussis - Homo sapiens (human) hsa05140 Leishmaniasis - Homo sapiens (human) hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05152 Tuberculosis - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human) hsa05161 Hepatitis B - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05210 Colorectal cancer - Homo sapiens (human) hsa05211 Renal cell carcinoma - Homo sapiens (human) hsa05212 Pancreatic cancer - Homo sapiens (human) hsa05213 Endometrial cancer - Homo sapiens (human) hsa05214 Glioma - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05216 Thyroid cancer - Homo sapiens (human) hsa05218 Melanoma - Homo sapiens (human) hsa05219 Bladder cancer - Homo sapiens (human) hsa05220 Chronic myeloid leukemia - Homo sapiens (human) hsa05221 Acute myeloid leukemia - Homo sapiens (human) hsa05223 Non-small cell lung cancer - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human) hsa05231 Choline metabolism in cancer - Homo sapiens (human)",CHEMBL CHEMBL526566,P03956,Matrix metalloproteinase-1,1.0,PRIMARY,NO,C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)NCC(C)(C)C)C(=O)CO,2,3,"InChI=1S/C28H40FNO6/c1-16-11-20-19-8-7-17-12-18(32)9-10-25(17,5)27(19,29)21(33)13-26(20,6)28(16,22(34)14-31)36-23(35)30-15-24(2,3)4/h9-10,12,16,19-21,31,33H,7-8,11,13-15H2,1-6H3,(H,30,35)/t16-,19-,20-,21-,25-,26-,27-,28-/m0/s1",QIOJSKJMCPAOBC-XYWKZLDCSA-N,"c(""Matrix metalloproteinase-1"", ""Glucocorticoid receptor"")",4312,MMP1,Hemostasis R-HSA-109582 Collagen degradation R-HSA-1442490 Degradation of the extracellular matrix R-HSA-1474228 Extracellular matrix organization R-HSA-1474244 Collagen formation R-HSA-1474290 Activation of Matrix Metalloproteinases R-HSA-1592389 Signal Transduction R-HSA-162582 Assembly of collagen fibrils and other multimeric structures R-HSA-2022090 Cell surface interactions at the vascular wall R-HSA-202733 Basigin interactions R-HSA-210991 EGFR Transactivation by Gastrin R-HSA-2179392 Signaling by GPCR R-HSA-372790 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-381426 Metabolism of proteins R-HSA-392499 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,extracellular region GO:0005576 TAS proteinaceous extracellular matrix GO:0005578 IEA,GO:0006508 proteolysis 15863497 19022250 IDA GO:0016032 viral process IEA GO:0022617 extracellular matrix disassembly TAS GO:0030574 collagen catabolic process TAS GO:0032461 positive regulation of protein oligomerization 19022250 IDA GO:0044267 cellular protein metabolic process TAS GO:0050900 leukocyte migration TAS,endopeptidase activity GO:0004175 IDA 19022250 metalloendopeptidase activity GO:0004222 IDA 9920899 metalloendopeptidase activity GO:0004222 TAS serine-type endopeptidase activity GO:0004252 TAS calcium ion binding GO:0005509 IEA zinc ion binding GO:0008270 IEA,hsa03320 PPAR signaling pathway - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05219 Bladder cancer - Homo sapiens (human) hsa05323 Rheumatoid arthritis - Homo sapiens (human),CHEMBL CHEMBL570296,Q99705,Melanin-concentrating hormone receptor 1,1.0,ORTHOGONAL,NO,CCCNCc1ccc(CCN2C=CC(=CC2=O)OCc3ccc(F)cc3)cc1,10,12,"InChI=1S/C24H27FN2O2/c1-2-13-26-17-20-5-3-19(4-6-20)11-14-27-15-12-23(16-24(27)28)29-18-21-7-9-22(25)10-8-21/h3-10,12,15-16,26H,2,11,13-14,17-18H2,1H3",YYCDRZDDLBLWPS-UHFFFAOYSA-N,"c(""Melanin-concentrating hormone receptor 1"", ""Unchecked"", ""Mu opioid receptor"", ""Kappa opioid receptor"", ""Delta opioid receptor"", ""Histamine H1 receptor"", ""Histamine H2 receptor"", ""Histamine H3 receptor"", ""Histamine H4 receptor"", ""Adenosine A2a receptor"", ""Muscarinic acetylcholine receptor M1"")",2847,MCHR1,R-HSA-162582 Signal Transduction R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding R-HSA-5617833 Assembly of the primary cilium R-HSA-5620920 Cargo trafficking to the periciliary membrane R-HSA-5620922 BBSome-mediated cargo-targeting to cilium R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,plasma membrane GO:0005886 TAS integral component of plasma membrane 10421367 GO:0005887 TAS nonmotile primary cilium GO:0031513 ISS,generation of precursor metabolites and energy GO:0006091 TAS 10421367 cell surface receptor signaling pathway GO:0007166 IBA G-protein coupled receptor signaling pathway GO:0007186 TAS 10421368 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 TAS 10421367 positive regulation of cytosolic calcium ion concentration GO:0007204 TAS 10421367 neuropeptide signaling pathway GO:0007218 IEA feeding behavior GO:0007631 TAS 10421367,TAS 10421367 G-protein coupled receptor activity GO:0004930 TAS 10860944 neuropeptide receptor activity GO:0008188 IBA GO:0030273 melanin-concentrating hormone receptor activity,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL2032049,Q99705,Melanin-concentrating hormone receptor 1,1.0,PRIMARY,NO,C[C@@H]1[C@H]2CN(CCC3(CCCCC3)C(=O)O)CC[C@@H]2Cc4[nH]c5ccc(cc5c14)C(F)(F)F,13,17,"InChI=1S/C26H33F3N2O2/c1-16-20-15-31(12-10-25(24(32)33)8-3-2-4-9-25)11-7-17(20)13-22-23(16)19-14-18(26(27,28)29)5-6-21(19)30-22/h5-6,14,16-17,20,30H,2-4,7-13,15H2,1H3,(H,32,33)/t16-,17-,20-/m1/s1",WAOZNBXSEVIAGX-MBOZVWFJSA-N,"c(""Melanin-concentrating hormone receptor 1"", ""Melanin-concentrating hormone receptor 2"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 2c (5-HT2c) receptor"", ""Dopamine D1 receptor"", ""Dopamine D2 receptor"", ""Alpha-2a adrenergic receptor"", ""Alpha-2c adrenergic receptor"", ""Mu opioid receptor"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M3"", ""Norepinephrine transporter"", ""Serotonin transporter"")",2847,MCHR1,R-HSA-162582 Signal Transduction R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding R-HSA-5617833 Assembly of the primary cilium R-HSA-5620920 Cargo trafficking to the periciliary membrane R-HSA-5620922 BBSome-mediated cargo-targeting to cilium R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,plasma membrane GO:0005886 TAS integral component of plasma membrane 10421367 GO:0005887 TAS nonmotile primary cilium GO:0031513 ISS,generation of precursor metabolites and energy GO:0006091 TAS 10421367 cell surface receptor signaling pathway GO:0007166 IBA G-protein coupled receptor signaling pathway GO:0007186 TAS 10421368 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 TAS 10421367 positive regulation of cytosolic calcium ion concentration GO:0007204 TAS 10421367 neuropeptide signaling pathway GO:0007218 IEA feeding behavior GO:0007631 TAS 10421367,TAS 10421367 G-protein coupled receptor activity GO:0004930 TAS 10860944 neuropeptide receptor activity GO:0008188 IBA GO:0030273 melanin-concentrating hormone receptor activity,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL1934130,Q969V1,Melanin-concentrating hormone receptor 2,1.0,PRIMARY,NO,CC(=O)N[C@@H]1CC2(CCN(Cc3ccc4c(c3)c5ccccc5n4C(=O)N)CC2)c6ccccc16,3,6,"InChI=1S/C29H30N4O2/c1-19(34)31-25-17-29(24-8-4-2-7-22(24)25)12-14-32(15-13-29)18-20-10-11-27-23(16-20)21-6-3-5-9-26(21)33(27)28(30)35/h2-11,16,25H,12-15,17-18H2,1H3,(H2,30,35)(H,31,34)/t25-/m1/s1",WFKZKRWZCHJQIT-RUZDIDTESA-N,"c(""Melanin-concentrating hormone receptor 2"", ""Unchecked"", ""Dopamine D2 receptor"", ""Serotonin transporter"")",84539,MCHR2,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane IBA,IBA GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IBA GO:0007218 neuropeptide signaling pathway IEA GO:0061737 leukotriene signaling pathway,IBA GO:0001631 cysteinyl leukotriene receptor activity IBA GO:0008528 G-protein coupled peptide receptor activity,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL275067,Q01726,Melanocortin receptor 1,1.0,ORTHOGONAL,NO,CCCC(=O)C1(CCN(CC1)C(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](Cc3c[nH]cn3)NC(=O)C)c4ccccc4,4,9,"InChI=1S/C33H41N5O5/c1-4-8-30(40)33(25-9-6-5-7-10-25)15-17-38(18-16-33)32(42)29(19-24-11-13-27(43-3)14-12-24)37-31(41)28(36-23(2)39)20-26-21-34-22-35-26/h5-7,9-14,21-22,28-29H,4,8,15-20H2,1-3H3,(H,34,35)(H,36,39)(H,37,41)/t28-,29-/m1/s1",LGKJAWXHTMWMPF-FQLXRVMXSA-N,"c(""Melanocortin receptor 1"", ""Melanocortin receptor 3"", ""Melanocortin receptor 4"", ""Melanocortin receptor 5"")",4157,MSHR,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418555 G alpha (s) signalling events R-HSA-500792 GPCR ligand binding,intracellular IEA GO:0005622 plasma membrane IDA 19452503 GO:0005886 plasma membrane TAS GO:0005886 integral component of plasma membrane TAS 9571181 GO:0005887,"9571181 TAS GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 7581459 TAS GO:0007275 multicellular organism development 7581459 TAS GO:0009650 UV protection 18292087 ISS GO:0010739 positive regulation of protein kinase A signaling IEA GO:0019233 sensory perception of pain 19329486 19743876 IDA GO:0030819 positive regulation of cAMP biosynthetic process 10233018 IMP GO:0032720 negative regulation of tumor necrosis factor production 18292087 ISS GO:0035556 intracellular signal transduction IEA GO:0042438 melanin biosynthetic process 18292087 TAS GO:0043473 pigmentation 18292087 ISS GO:0045944 positive regulation of transcription from RNA polymerase II promoter 18292087 ISS GO:0051897 positive regulation of protein kinase B signaling 18292087 IDA GO:0070914 UV-damage excision repair 18292087 ISS GO:0090037 positive regulation of protein kinase C signaling",melanocortin receptor activity GO:0004977 9571181 TAS melanocyte-stimulating hormone receptor activity GO:0004980 19743876 IPI protein binding GO:0005515 19329486 19743876 IPI G-protein coupled peptide receptor activity GO:0008528 18292087 TAS ubiquitin protein ligase binding GO:0031625 19737927 IPI,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04916 Melanogenesis - Homo sapiens (human),CHEMBL CHEMBL218748,Q01726,Melanocortin receptor 1,1.0,PRIMARY,NO,O=C(Cc1ccccc1)N2C[C@@H]3CCCN3C[C@@H]2Cc4ccccc4,4,12,"InChI=1S/C22H26N2O/c25-22(15-19-10-5-2-6-11-19)24-17-20-12-7-13-23(20)16-21(24)14-18-8-3-1-4-9-18/h1-6,8-11,20-21H,7,12-17H2/t20-,21-/m0/s1",QXRXXIKAVZAGHZ-SFTDATJTSA-N,"c(""Melanocortin receptor 1"", ""Melanocortin receptor 3"", ""Melanocortin receptor 4"", ""Melanocortin receptor 5"", ""Unchecked"")",4157,MSHR,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418555 G alpha (s) signalling events R-HSA-500792 GPCR ligand binding,intracellular IEA GO:0005622 plasma membrane IDA 19452503 GO:0005886 plasma membrane TAS GO:0005886 integral component of plasma membrane TAS 9571181 GO:0005887,"9571181 TAS GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 7581459 TAS GO:0007275 multicellular organism development 7581459 TAS GO:0009650 UV protection 18292087 ISS GO:0010739 positive regulation of protein kinase A signaling IEA GO:0019233 sensory perception of pain 19329486 19743876 IDA GO:0030819 positive regulation of cAMP biosynthetic process 10233018 IMP GO:0032720 negative regulation of tumor necrosis factor production 18292087 ISS GO:0035556 intracellular signal transduction IEA GO:0042438 melanin biosynthetic process 18292087 TAS GO:0043473 pigmentation 18292087 ISS GO:0045944 positive regulation of transcription from RNA polymerase II promoter 18292087 ISS GO:0051897 positive regulation of protein kinase B signaling 18292087 IDA GO:0070914 UV-damage excision repair 18292087 ISS GO:0090037 positive regulation of protein kinase C signaling",melanocortin receptor activity GO:0004977 9571181 TAS melanocyte-stimulating hormone receptor activity GO:0004980 19743876 IPI protein binding GO:0005515 19329486 19743876 IPI G-protein coupled peptide receptor activity GO:0008528 18292087 TAS ubiquitin protein ligase binding GO:0031625 19737927 IPI,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04916 Melanogenesis - Homo sapiens (human),CHEMBL CHEMBL3601432,Q01726,Melanocortin receptor 1,1.0,PRIMARY,YES,CCCC[C@@H](NC(=O)C)C(=O)N[C@H]1CC(=O)NCCCC[C@H](N(C)C(=O)[C@H](Cc2c[nH]c3ccccc23)N(C)C(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc4ccc5ccccc5c4)N(C)C(=O)[C@H](Cc6cnc[nH]6)N(C)C1=O)C(=O)N,4,16,"InChI=1S/C59H81N15O9/c1-8-9-20-44(68-36(2)75)53(78)69-45-32-51(76)64-26-15-14-22-46(52(60)77)70(3)57(82)49(30-40-33-66-43-21-13-12-19-42(40)43)74(7)55(80)47(23-16-27-65-59(61)62)71(4)56(81)48(29-37-24-25-38-17-10-11-18-39(38)28-37)73(6)58(83)50(72(5)54(45)79)31-41-34-63-35-67-41/h10-13,17-19,21,24-25,28,33-35,44-50,66H,8-9,14-16,20,22-23,26-27,29-32H2,1-7H3,(H2,60,77)(H,63,67)(H,64,76)(H,68,75)(H,69,78)(H4,61,62,65)/t44-,45+,46+,47+,48-,49+,50+/m1/s1",JQBPGTIPRHEONU-VVPYAFNRSA-N,"c(""Melanocortin receptor 1"", ""Melanocortin receptor 3"", ""Melanocortin receptor 4"", ""Melanocortin receptor 5"")",4157,MSHR,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418555 G alpha (s) signalling events R-HSA-500792 GPCR ligand binding,intracellular IEA GO:0005622 plasma membrane IDA 19452503 GO:0005886 plasma membrane TAS GO:0005886 integral component of plasma membrane TAS 9571181 GO:0005887,"9571181 TAS GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 7581459 TAS GO:0007275 multicellular organism development 7581459 TAS GO:0009650 UV protection 18292087 ISS GO:0010739 positive regulation of protein kinase A signaling IEA GO:0019233 sensory perception of pain 19329486 19743876 IDA GO:0030819 positive regulation of cAMP biosynthetic process 10233018 IMP GO:0032720 negative regulation of tumor necrosis factor production 18292087 ISS GO:0035556 intracellular signal transduction IEA GO:0042438 melanin biosynthetic process 18292087 TAS GO:0043473 pigmentation 18292087 ISS GO:0045944 positive regulation of transcription from RNA polymerase II promoter 18292087 ISS GO:0051897 positive regulation of protein kinase B signaling 18292087 IDA GO:0070914 UV-damage excision repair 18292087 ISS GO:0090037 positive regulation of protein kinase C signaling",melanocortin receptor activity GO:0004977 9571181 TAS melanocyte-stimulating hormone receptor activity GO:0004980 19743876 IPI protein binding GO:0005515 19329486 19743876 IPI G-protein coupled peptide receptor activity GO:0008528 18292087 TAS ubiquitin protein ligase binding GO:0031625 19737927 IPI,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04916 Melanogenesis - Homo sapiens (human),CHEMBL CHEMBL405282,P41968,Melanocortin receptor 3,1.0,PRIMARY,NO,CSCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc6ccccc6)C(=O)NCC(=O)O,3,18,"InChI=1S/C74H99N21O16S/c1-41(2)62(95-63(102)49(75)30-44-22-24-47(96)25-23-44)72(111)90-53(26-29-112-3)64(103)84-38-59(97)87-57(34-46-37-80-40-86-46)70(109)92-55(32-43-16-8-5-9-17-43)68(107)88-52(21-13-28-82-74(78)79)67(106)93-56(33-45-36-83-50-19-11-10-18-48(45)50)69(108)94-58(35-60(98)99)71(110)89-51(20-12-27-81-73(76)77)66(105)91-54(65(104)85-39-61(100)101)31-42-14-6-4-7-15-42/h4-11,14-19,22-25,36-37,40-41,49,51-58,62,83,96H,12-13,20-21,26-35,38-39,75H2,1-3H3,(H,80,86)(H,84,103)(H,85,104)(H,87,97)(H,88,107)(H,89,110)(H,90,111)(H,91,105)(H,92,109)(H,93,106)(H,94,108)(H,95,102)(H,98,99)(H,100,101)(H4,76,77,81)(H4,78,79,82)/t49-,51-,52-,53-,54-,55-,56+,57-,58-,62-/m0/s1",GZWUQPQBOGLSIM-MDMVXOTPSA-N,"c(""Melanocortin receptor 3"", ""Melanocortin receptor 4"", ""Melanocortin receptor 5"")",4159,MC3R,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418555 G alpha (s) signalling events R-HSA-500792 GPCR ligand binding,GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 8463333 TAS,"regulation of heart rate GO:0002027 IEA G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 8175743 TAS adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007188 IEA phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 8175743 TAS regulation of blood pressure GO:0008217 IEA positive regulation of cAMP biosynthetic process GO:0030819 19329486 19743876 IDA circadian regulation of gene expression GO:0032922 ISS homoiothermy GO:0042309 IEA locomotor rhythm GO:0045475 IEA sodium ion homeostasis GO:0055078 IEA regulation of feeding behavior GO:0060259 IEA",melanocortin receptor activity 8175743 GO:0004977 TAS melanocyte-stimulating hormone receptor activity 19743876 GO:0004980 IPI protein binding 19329486 19743876 GO:0005515 IPI peptide hormone binding GO:0017046 IEA neuropeptide binding 15927146 GO:0042923 IPI,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL264190,P32245,Melanocortin receptor 4,1.0,ORTHOGONAL,NO,CC(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@H](Cc2ccccc2)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N,4,20,"InChI=1S/C34H43N11O5/c1-20(46)42-29(16-23-18-38-19-41-23)33(50)45-28(14-21-8-3-2-4-9-21)32(49)43-26(12-7-13-39-34(36)37)31(48)44-27(30(35)47)15-22-17-40-25-11-6-5-10-24(22)25/h2-6,8-11,17-19,26-29,40H,7,12-16H2,1H3,(H2,35,47)(H,38,41)(H,42,46)(H,43,49)(H,44,48)(H,45,50)(H4,36,37,39)/t26-,27-,28+,29-/m0/s1",DFCJPPDAOZROBS-FKWFRFQNSA-N,"c(""Unchecked"", ""Melanocortin receptor 1"", ""Melanocortin receptor 3"", ""Melanocortin receptor 4"", ""Melanocortin receptor 5"")",4160,MC4R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (s) signalling events R-HSA-418555 GPCR ligand binding R-HSA-500792,nucleus GO:0005634 IEA plasma membrane GO:0005886 TAS integral component of membrane GO:0016021 IEA,diet induced thermogenesis GO:0002024 IEA energy reserve metabolic process GO:0006112 IEA adenylate cyclase-modulating G-protein coupled receptor signaling pathway 8794897 GO:0007188 TAS feeding behavior GO:0007631 IEA insulin secretion GO:0030073 IEA positive regulation of cAMP biosynthetic process 19329486 19743876 GO:0030819 IDA response to insulin GO:0032868 IEA positive regulation of bone resorption 16614075 GO:0045780 IMP negative regulation of feeding behavior GO:2000252 IEA regulation of grooming behavior GO:2000821 IEA,8794897 GO:0004977 melanocortin receptor activity TAS 14764818 GO:0004980 melanocyte-stimulating hormone receptor activity IDA 19743876 GO:0004980 melanocyte-stimulating hormone receptor activity IPI 19329486 19743876 GO:0005515 protein binding IPI GO:0017046 peptide hormone binding IEA 19737927 GO:0031625 ubiquitin protein ligase binding IPI 15927146 GO:0042923 neuropeptide binding IPI,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL339053,P32245,Melanocortin receptor 4,1.0,PRIMARY,NO,Clc1ccc(C[C@@H](NC(=O)[C@H]2Cc3ccccc3CN2)C(=O)N4CCC(Cn5cncn5)(CC4)C6CCCCC6)cc1,4,98,"InChI=1S/C33H41ClN6O2/c34-28-12-10-24(11-13-28)18-30(38-31(41)29-19-25-6-4-5-7-26(25)20-36-29)32(42)39-16-14-33(15-17-39,21-40-23-35-22-37-40)27-8-2-1-3-9-27/h4-7,10-13,22-23,27,29-30,36H,1-3,8-9,14-21H2,(H,38,41)/t29-,30-/m1/s1",HLCHESOMJVGDSJ-LOYHVIPDSA-N,"c(""Melanocortin receptor 4"", ""Melanocortin receptor (M3 and M4)"", ""Melanocortin receptor 3"", ""Melanocortin receptor 5"", ""Melanocortin receptor 1"", ""ADMET"", ""Unchecked"")",4160,MC4R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (s) signalling events R-HSA-418555 GPCR ligand binding R-HSA-500792,nucleus GO:0005634 IEA plasma membrane GO:0005886 TAS integral component of membrane GO:0016021 IEA,diet induced thermogenesis GO:0002024 IEA energy reserve metabolic process GO:0006112 IEA adenylate cyclase-modulating G-protein coupled receptor signaling pathway 8794897 GO:0007188 TAS feeding behavior GO:0007631 IEA insulin secretion GO:0030073 IEA positive regulation of cAMP biosynthetic process 19329486 19743876 GO:0030819 IDA response to insulin GO:0032868 IEA positive regulation of bone resorption 16614075 GO:0045780 IMP negative regulation of feeding behavior GO:2000252 IEA regulation of grooming behavior GO:2000821 IEA,8794897 GO:0004977 melanocortin receptor activity TAS 14764818 GO:0004980 melanocyte-stimulating hormone receptor activity IDA 19743876 GO:0004980 melanocyte-stimulating hormone receptor activity IPI 19329486 19743876 GO:0005515 protein binding IPI GO:0017046 peptide hormone binding IEA 19737927 GO:0031625 ubiquitin protein ligase binding IPI 15927146 GO:0042923 neuropeptide binding IPI,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL1209788,P32245,Melanocortin receptor 4,1.0,ORTHOGONAL,YES,Cc1cc2[C@H](OC3(CCN(CC3)C(=O)[C@@H]4CN(C[C@H]4c5ccc(F)cc5F)C6CCOCC6)c2cc1Cl)C(C)(C)C#N,4,14,"InChI=1S/C33H38ClF2N3O3/c1-20-14-24-27(16-28(20)34)33(42-30(24)32(2,3)19-37)8-10-38(11-9-33)31(40)26-18-39(22-6-12-41-13-7-22)17-25(26)23-5-4-21(35)15-29(23)36/h4-5,14-16,22,25-26,30H,6-13,17-18H2,1-3H3/t25-,26+,30-/m0/s1",BCFFSQJVHOEAAU-MWSYKCOMSA-N,"c(""Melanocortin receptor 4"", ""Melatonin receptor 1B"", ""Unchecked"", ""Melanocortin receptor 3"", ""Melanocortin receptor 5"")",4160,MC4R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (s) signalling events R-HSA-418555 GPCR ligand binding R-HSA-500792,nucleus GO:0005634 IEA plasma membrane GO:0005886 TAS integral component of membrane GO:0016021 IEA,diet induced thermogenesis GO:0002024 IEA energy reserve metabolic process GO:0006112 IEA adenylate cyclase-modulating G-protein coupled receptor signaling pathway 8794897 GO:0007188 TAS feeding behavior GO:0007631 IEA insulin secretion GO:0030073 IEA positive regulation of cAMP biosynthetic process 19329486 19743876 GO:0030819 IDA response to insulin GO:0032868 IEA positive regulation of bone resorption 16614075 GO:0045780 IMP negative regulation of feeding behavior GO:2000252 IEA regulation of grooming behavior GO:2000821 IEA,8794897 GO:0004977 melanocortin receptor activity TAS 14764818 GO:0004980 melanocyte-stimulating hormone receptor activity IDA 19743876 GO:0004980 melanocyte-stimulating hormone receptor activity IPI 19329486 19743876 GO:0005515 protein binding IPI GO:0017046 peptide hormone binding IEA 19737927 GO:0031625 ubiquitin protein ligase binding IPI 15927146 GO:0042923 neuropeptide binding IPI,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL3601426,P32245,Melanocortin receptor 4,1.0,PRIMARY,YES,CCCC[C@@H](NC(=O)C)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)N(C)C(=O)[C@@H](Cc4ccc5ccccc5c4)N(C)C(=O)[C@H](Cc6cnc[nH]6)N(C)C1=O)C(=O)N,4,16,"InChI=1S/C57H77N15O9/c1-6-7-18-43(66-34(2)73)51(76)69-45-30-49(74)62-24-13-12-20-42(50(58)75)67-52(77)44(28-38-31-64-41-19-11-10-17-40(38)41)68-53(78)46(21-14-25-63-57(59)60)70(3)55(80)47(27-35-22-23-36-15-8-9-16-37(36)26-35)72(5)56(81)48(71(4)54(45)79)29-39-32-61-33-65-39/h8-11,15-17,19,22-23,26,31-33,42-48,64H,6-7,12-14,18,20-21,24-25,27-30H2,1-5H3,(H2,58,75)(H,61,65)(H,62,74)(H,66,73)(H,67,77)(H,68,78)(H,69,76)(H4,59,60,63)/t42-,43+,44-,45-,46-,47+,48-/m0/s1",TVKPENPJQKTJFK-SHVRLUCGSA-N,"c(""Melanocortin receptor 1"", ""Melanocortin receptor 3"", ""Melanocortin receptor 4"", ""Melanocortin receptor 5"")",4160,MC4R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (s) signalling events R-HSA-418555 GPCR ligand binding R-HSA-500792,nucleus GO:0005634 IEA plasma membrane GO:0005886 TAS integral component of membrane GO:0016021 IEA,diet induced thermogenesis GO:0002024 IEA energy reserve metabolic process GO:0006112 IEA adenylate cyclase-modulating G-protein coupled receptor signaling pathway 8794897 GO:0007188 TAS feeding behavior GO:0007631 IEA insulin secretion GO:0030073 IEA positive regulation of cAMP biosynthetic process 19329486 19743876 GO:0030819 IDA response to insulin GO:0032868 IEA positive regulation of bone resorption 16614075 GO:0045780 IMP negative regulation of feeding behavior GO:2000252 IEA regulation of grooming behavior GO:2000821 IEA,8794897 GO:0004977 melanocortin receptor activity TAS 14764818 GO:0004980 melanocyte-stimulating hormone receptor activity IDA 19743876 GO:0004980 melanocyte-stimulating hormone receptor activity IPI 19329486 19743876 GO:0005515 protein binding IPI GO:0017046 peptide hormone binding IEA 19737927 GO:0031625 ubiquitin protein ligase binding IPI 15927146 GO:0042923 neuropeptide binding IPI,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL220018,P33032,Melanocortin receptor 5,1.0,ORTHOGONAL,NO,NC(=N)NCCC[C@H](NC(=O)CCc1c[nH]c2ccccc12)C(=O)N3C[C@@H]4CCCN4C[C@@H]3Cc5ccccc5,4,10,"InChI=1S/C31H41N7O2/c32-31(33)34-16-6-13-28(36-29(39)15-14-23-19-35-27-12-5-4-11-26(23)27)30(40)38-21-24-10-7-17-37(24)20-25(38)18-22-8-2-1-3-9-22/h1-5,8-9,11-12,19,24-25,28,35H,6-7,10,13-18,20-21H2,(H,36,39)(H4,32,33,34)/t24-,25-,28-/m0/s1",QJJUWWQDEUFNRO-VBOOUTDYSA-N,"c(""Melanocortin receptor 4"", ""Melanocortin receptor 1"", ""Melanocortin receptor 3"", ""Melanocortin receptor 5"")",4161,MC5R,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418555 G alpha (s) signalling events R-HSA-500792 GPCR ligand binding,TAS GO:0005886 plasma membrane TAS 7739752 integral component of plasma membrane GO:0005887,"7739752 GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 19329486 GO:0030819 positive regulation of cAMP biosynthetic process IDA",melanocortin receptor activity IEA GO:0004977 protein binding IPI 19329486 GO:0005515 hormone binding IEA GO:0042562,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL2371968,P33032,Melanocortin receptor 5,1.0,PRIMARY,NO,CCCC[C@H](NC(=O)C)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]4CCCCN4C(=O)[C@H](Cc5ccc(cc5)c6ccccc6)NC(=O)[C@@H]7CC8CCCCC8N7C1=O)C(=O)N,4,11,"InChI=1S/C59H76N10O9/c1-3-4-20-45(63-36(2)70)54(73)66-48-34-52(71)61-29-14-12-22-44(53(60)72)64-55(74)46(32-41-35-62-43-21-10-9-19-42(41)43)65-56(75)50-24-13-15-30-68(50)58(77)47(31-37-25-27-39(28-26-37)38-16-6-5-7-17-38)67-57(76)51-33-40-18-8-11-23-49(40)69(51)59(48)78/h5-7,9-10,16-17,19,21,25-28,35,40,44-51,62H,3-4,8,11-15,18,20,22-24,29-34H2,1-2H3,(H2,60,72)(H,61,71)(H,63,70)(H,64,74)(H,65,75)(H,66,73)(H,67,76)/t40?,44-,45-,46-,47-,48-,49?,50-,51-/m0/s1",BMAPOAMSOKHHLD-ZNLSIPTCSA-N,"c(""Melanocortin receptor 1"", ""Melanocortin receptor 3"", ""Melanocortin receptor 4"", ""Melanocortin receptor 5"", ""Unchecked"", ""Melanocortin receptor (M4 and M5)"")",4161,MC5R,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418555 G alpha (s) signalling events R-HSA-500792 GPCR ligand binding,TAS GO:0005886 plasma membrane TAS 7739752 integral component of plasma membrane GO:0005887,"7739752 GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 19329486 GO:0030819 positive regulation of cAMP biosynthetic process IDA",melanocortin receptor activity IEA GO:0004977 protein binding IPI 19329486 GO:0005515 hormone binding IEA GO:0042562,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL429392,P48039,Melatonin receptor 1A,1.0,PRIMARY,NO,CC(=O)NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C)c4c3)cc12,2,14,"InChI=1S/C31H34N2O4/c1-22(34)32-16-14-26-8-3-6-24-10-12-28(20-30(24)26)36-18-5-19-37-29-13-11-25-7-4-9-27(31(25)21-29)15-17-33-23(2)35/h3-4,6-13,20-21H,5,14-19H2,1-2H3,(H,32,34)(H,33,35)",NSXBZYDTTKLTOH-UHFFFAOYSA-N,"c(""Melatonin receptor 1A"", ""Melatonin receptor 1B"", ""Melatonin receptor"", ""Unchecked"")",4543,MTR1A,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,TAS GO:0005886 plasma membrane 10531408 IDA GO:0005887 integral component of plasma membrane IEA GO:0043025 neuronal cell body 10531408 IDA GO:0043235 receptor complex,"cell surface receptor signaling pathway IBA GO:0007166 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 9645677 GO:0007187 aging IEA GO:0007568 mating behavior TAS 7946354 GO:0007617 circadian rhythm IEA GO:0007623 positive regulation of cGMP biosynthetic process IDA 10531408 GO:0030828 camera-type eye development IEA GO:0043010 negative regulation of insulin secretion IEA GO:0046676",GO:0005515 protein binding 20859254 IPI GO:0008502 melatonin receptor activity IEA GO:0042562 hormone binding 10531408 IPI GO:0097159 organic cyclic compound binding 10531408 IPI,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Circadian entrainment - Homo sapiens (human) hsa04713,CHEMBL CHEMBL2326199,P49286,Melatonin receptor 1B,1.0,ORTHOGONAL,NO,CCC(=O)NCCCc1cc(OC)ccc1OCc2cccc(OC)c2,2,9,"InChI=1S/C21H27NO4/c1-4-21(23)22-12-6-8-17-14-19(25-3)10-11-20(17)26-15-16-7-5-9-18(13-16)24-2/h5,7,9-11,13-14H,4,6,8,12,15H2,1-3H3,(H,22,23)",FPWCECQCQIIXNN-UHFFFAOYSA-N,"c(""Unchecked"", ""Melatonin receptor 1B"", ""Melatonin receptor 1A"")",4544,MTR1B,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,cytosol GO:0005829 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 7568007 TAS,"GO:0007166 cell surface receptor signaling pathway IBA GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 7568007 TAS GO:0007268 chemical synaptic transmission 7568007 TAS GO:0007623 circadian rhythm IBA GO:0030824 negative regulation of cGMP metabolic process IEA GO:0042593 glucose homeostasis 20668700 IMP GO:0043010 camera-type eye development IEA GO:0043524 negative regulation of neuron apoptotic process IEA GO:0045909 positive regulation of vasodilation IEA GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep IEA GO:0046676 negative regulation of insulin secretion IEA GO:0050796 regulation of insulin secretion 20668700 IMP GO:0051481 negative regulation of cytosolic calcium ion concentration IEA GO:0051970 negative regulation of transmission of nerve impulse IEA GO:0051971 positive regulation of transmission of nerve impulse IEA GO:0098908 regulation of neuronal action potential IEA GO:1902260 negative regulation of delayed rectifier potassium channel activity IEA",G-protein coupled receptor activity GO:0004930 TAS 7568007 protein binding GO:0005515 IPI 20859254 26514267 melatonin receptor activity GO:0008502 IEA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04713 Circadian entrainment - Homo sapiens (human),CHEMBL CHEMBL33185,P49286,Melatonin receptor 1B,1.0,PRIMARY,NO,CCC(=O)NCc1cc2c(OC)cccc2n1Cc3ccc(Cl)cc3,2,13,"InChI=1S/C20H21ClN2O2/c1-3-20(24)22-12-16-11-17-18(5-4-6-19(17)25-2)23(16)13-14-7-9-15(21)10-8-14/h4-11H,3,12-13H2,1-2H3,(H,22,24)",XXXKKZBZKUDKMA-UHFFFAOYSA-N,"c(""Melatonin receptor 1A"", ""Melatonin receptor 1B"")",4544,MTR1B,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,cytosol GO:0005829 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 7568007 TAS,"GO:0007166 cell surface receptor signaling pathway IBA GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 7568007 TAS GO:0007268 chemical synaptic transmission 7568007 TAS GO:0007623 circadian rhythm IBA GO:0030824 negative regulation of cGMP metabolic process IEA GO:0042593 glucose homeostasis 20668700 IMP GO:0043010 camera-type eye development IEA GO:0043524 negative regulation of neuron apoptotic process IEA GO:0045909 positive regulation of vasodilation IEA GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep IEA GO:0046676 negative regulation of insulin secretion IEA GO:0050796 regulation of insulin secretion 20668700 IMP GO:0051481 negative regulation of cytosolic calcium ion concentration IEA GO:0051970 negative regulation of transmission of nerve impulse IEA GO:0051971 positive regulation of transmission of nerve impulse IEA GO:0098908 regulation of neuronal action potential IEA GO:1902260 negative regulation of delayed rectifier potassium channel activity IEA",G-protein coupled receptor activity GO:0004930 TAS 7568007 protein binding GO:0005515 IPI 20859254 26514267 melatonin receptor activity GO:0008502 IEA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04713 Circadian entrainment - Homo sapiens (human),CHEMBL CHEMBL3580926,P49286,Melatonin receptor 1B,1.0,ORTHOGONAL,YES,CCNc1nnc(Cc2c[nH]c3ccc(OC)cc23)s1,2,5,"InChI=1S/C14H16N4OS/c1-3-15-14-18-17-13(20-14)6-9-8-16-12-5-4-10(19-2)7-11(9)12/h4-5,7-8,16H,3,6H2,1-2H3,(H,15,18)",DIDVMNKRIDUMKO-UHFFFAOYSA-N,"c(""Melatonin receptor 1A"", ""Melatonin receptor 1B"", ""Unchecked"")",4544,MTR1B,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,cytosol GO:0005829 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 7568007 TAS,"GO:0007166 cell surface receptor signaling pathway IBA GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 7568007 TAS GO:0007268 chemical synaptic transmission 7568007 TAS GO:0007623 circadian rhythm IBA GO:0030824 negative regulation of cGMP metabolic process IEA GO:0042593 glucose homeostasis 20668700 IMP GO:0043010 camera-type eye development IEA GO:0043524 negative regulation of neuron apoptotic process IEA GO:0045909 positive regulation of vasodilation IEA GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep IEA GO:0046676 negative regulation of insulin secretion IEA GO:0050796 regulation of insulin secretion 20668700 IMP GO:0051481 negative regulation of cytosolic calcium ion concentration IEA GO:0051970 negative regulation of transmission of nerve impulse IEA GO:0051971 positive regulation of transmission of nerve impulse IEA GO:0098908 regulation of neuronal action potential IEA GO:1902260 negative regulation of delayed rectifier potassium channel activity IEA",G-protein coupled receptor activity GO:0004930 TAS 7568007 protein binding GO:0005515 IPI 20859254 26514267 melatonin receptor activity GO:0008502 IEA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04713 Circadian entrainment - Homo sapiens (human),CHEMBL CHEMBL491604,P49286,Melatonin receptor 1B,1.0,PRIMARY,YES,COc1ccc2cc(cc(CCNC(=O)C)c2c1)c3cccc(C=O)c3,2,7,"InChI=1S/C22H21NO3/c1-15(25)23-9-8-19-12-20(17-5-3-4-16(10-17)14-24)11-18-6-7-21(26-2)13-22(18)19/h3-7,10-14H,8-9H2,1-2H3,(H,23,25)",UPVFDHUOFQXFQX-UHFFFAOYSA-N,"c(""Melatonin receptor 1A"", ""Melatonin receptor 1B"", ""Unchecked"")",4544,MTR1B,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,cytosol GO:0005829 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 7568007 TAS,"GO:0007166 cell surface receptor signaling pathway IBA GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 7568007 TAS GO:0007268 chemical synaptic transmission 7568007 TAS GO:0007623 circadian rhythm IBA GO:0030824 negative regulation of cGMP metabolic process IEA GO:0042593 glucose homeostasis 20668700 IMP GO:0043010 camera-type eye development IEA GO:0043524 negative regulation of neuron apoptotic process IEA GO:0045909 positive regulation of vasodilation IEA GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep IEA GO:0046676 negative regulation of insulin secretion IEA GO:0050796 regulation of insulin secretion 20668700 IMP GO:0051481 negative regulation of cytosolic calcium ion concentration IEA GO:0051970 negative regulation of transmission of nerve impulse IEA GO:0051971 positive regulation of transmission of nerve impulse IEA GO:0098908 regulation of neuronal action potential IEA GO:1902260 negative regulation of delayed rectifier potassium channel activity IEA",G-protein coupled receptor activity GO:0004930 TAS 7568007 protein binding GO:0005515 IPI 20859254 26514267 melatonin receptor activity GO:0008502 IEA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04713 Circadian entrainment - Homo sapiens (human),CHEMBL CHEMBL3628113,Q13255,Metabotropic glutamate receptor 1,1.0,PRIMARY,NO,Cc1ccoc1C(=O)Nc2ccc(N3C(=O)c4cccc(F)c4C3=O)c(Cl)c2,8,21,"InChI=1S/C20H12ClFN2O4/c1-10-7-8-28-17(10)18(25)23-11-5-6-15(13(21)9-11)24-19(26)12-3-2-4-14(22)16(12)20(24)27/h2-9H,1H3,(H,23,25)",HHRZBUWNLICHOO-UHFFFAOYSA-N,"c(""Metabotropic glutamate receptor 1"", ""Metabotropic glutamate receptor 3"", ""Metabotropic glutamate receptor 2"", ""Unchecked"", ""Metabotropic glutamate receptor 4"", ""Metabotropic glutamate receptor 5"", ""Metabotropic glutamate receptor 6"", ""Metabotropic glutamate receptor 7"", ""Metabotropic glutamate receptor 8"")",2911,GRM1,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,nucleus GO:0005634 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane 24603153 GO:0005887 IMP postsynaptic density GO:0014069 IBA dendrite GO:0030425 IEA G-protein coupled receptor dimeric complex 24603153 GO:0038037 IDA G-protein coupled receptor homodimeric complex 10945991 GO:0038038 IPI,"activation of MAPKK activity GO:0000186 IEA activation of MAPK activity GO:0000187 IEA G-protein coupled receptor signaling pathway GO:0007186 IDA 24603153 protein kinase C-activating G-protein coupled receptor signaling pathway GO:0007205 IBA G-protein coupled glutamate receptor signaling pathway GO:0007216 IMP 24603153 chemical synaptic transmission GO:0007268 TAS 9076744 locomotory behavior GO:0007626 IEA sensory perception of pain GO:0019233 IEA dimeric G-protein coupled receptor signaling pathway GO:0038042 IDA 24603153 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0051482 IMP 24603153 regulation of sensory perception of pain GO:0051930 IEA regulation of synaptic transmission, glutamatergic GO:0051966 IBA cellular response to electrical stimulus GO:0071257 IEA",TAS 7476890 G-protein coupled receptor activity GO:0004930 IPI 19084525 protein binding GO:0005515 IDA 10945991 24603153 glutamate receptor activity GO:0008066 TAS 7476890 glutamate receptor activity GO:0008066,Calcium signaling pathway - Homo sapiens (human) hsa04020 FoxO signaling pathway - Homo sapiens (human) hsa04068 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Gap junction - Homo sapiens (human) hsa04540 Long-term potentiation - Homo sapiens (human) hsa04720 Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04723 Glutamatergic synapse - Homo sapiens (human) hsa04724 Long-term depression - Homo sapiens (human) hsa04730 Estrogen signaling pathway - Homo sapiens (human) hsa04915,CHEMBL CHEMBL3609742,Q14833,Metabotropic glutamate receptor 4,1.0,PRIMARY,NO,[2H]C([2H])(F)Oc1cc(NC(=O)c2ccccn2)ccc1Cl,6,6,"InChI=1S/C13H10ClFN2O2/c14-10-5-4-9(7-12(10)19-8-15)17-13(18)11-3-1-2-6-16-11/h1-7H,8H2,(H,17,18)/i8D2",SRGKMBLOTCYGBS-MGVXTIMCSA-N,"c(""Metabotropic glutamate receptor 4"", ""Metabotropic glutamate receptor 1"", ""Metabotropic glutamate receptor 2"", ""Metabotropic glutamate receptor 5"", ""Metabotropic glutamate receptor 6"", ""Metabotropic glutamate receptor 8"")",2914,GRM4,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 GPCR ligand binding R-HSA-500792,15102938 GO:0005622 intracellular IDA GO:0005886 plasma membrane TAS 15102938 GO:0005887 integral component of plasma membrane IDA 15102938 GO:0031410 cytoplasmic vesicle IDA GO:0042734 presynaptic membrane IBA,"IDA 15102938 activation of MAPK activity GO:0000187 IMP 15102938 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway GO:0007196 TAS 8738157 chemical synaptic transmission GO:0007268 TAS 15102938 neurotransmitter secretion GO:0007269 IEP 15102938 positive regulation of MAPK cascade GO:0043410 TAS 15102938 regulation of neuron apoptotic process GO:0043523 IBA GO:0051966 regulation of synaptic transmission, glutamatergic",IBA GO:0001642 group III metabotropic glutamate receptor activity 8738157 9473604 IMP GO:0004930 G-protein coupled receptor activity 8738157 9473604 IMP GO:0008066 glutamate receptor activity,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Glutamatergic synapse - Homo sapiens (human) hsa04724 Taste transduction - Homo sapiens (human) hsa04742,CHEMBL CHEMBL1830711,Q14833,Metabotropic glutamate receptor 4,1.0,PRIMARY,YES,C1Cc2n[nH]cc2c3nc(Nc4ncccn4)sc3C1,6,13,"InChI=1S/C13H12N6S/c1-3-9-8(7-16-19-9)11-10(4-1)20-13(17-11)18-12-14-5-2-6-15-12/h2,5-7H,1,3-4H2,(H,16,19)(H,14,15,17,18)",HYJWPTWQMAYKAM-UHFFFAOYSA-N,"c(""Metabotropic glutamate receptor 4"", ""Metabotropic glutamate receptor 1"", ""Metabotropic glutamate receptor 2"", ""Metabotropic glutamate receptor 3"", ""Metabotropic glutamate receptor 5"", ""Metabotropic glutamate receptor 7"")",2914,GRM4,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-420499 GPCR ligand binding R-HSA-500792,15102938 GO:0005622 intracellular IDA GO:0005886 plasma membrane TAS 15102938 GO:0005887 integral component of plasma membrane IDA 15102938 GO:0031410 cytoplasmic vesicle IDA GO:0042734 presynaptic membrane IBA,"IDA 15102938 activation of MAPK activity GO:0000187 IMP 15102938 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway GO:0007196 TAS 8738157 chemical synaptic transmission GO:0007268 TAS 15102938 neurotransmitter secretion GO:0007269 IEP 15102938 positive regulation of MAPK cascade GO:0043410 TAS 15102938 regulation of neuron apoptotic process GO:0043523 IBA GO:0051966 regulation of synaptic transmission, glutamatergic",IBA GO:0001642 group III metabotropic glutamate receptor activity 8738157 9473604 IMP GO:0004930 G-protein coupled receptor activity 8738157 9473604 IMP GO:0008066 glutamate receptor activity,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Glutamatergic synapse - Homo sapiens (human) hsa04724 Taste transduction - Homo sapiens (human) hsa04742,CHEMBL CHEMBL2440659,P41594,Metabotropic glutamate receptor 5,1.0,PRIMARY,NO,Cc1csc(NC(=O)c2cc(F)cc(Oc3cncnc3)c2)n1,44,71,"InChI=1S/C15H11FN4O2S/c1-9-7-23-15(19-9)20-14(21)10-2-11(16)4-12(3-10)22-13-5-17-8-18-6-13/h2-8H,1H3,(H,19,20,21)",AXVLPJHYYFHCHK-UHFFFAOYSA-N,"c(""Serotonin transporter"", ""Norepinephrine transporter"", ""Unchecked"", ""Dopamine transporter"", ""Neurokinin 1 receptor"", ""Sigma opioid receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 2b (5-HT2b) receptor"", ""Serotonin 3a (5-HT3a) receptor"", ""Prostanoid EP4 receptor"", ""Platelet activating factor receptor"", ""Mu opioid receptor"", ""Kappa opioid receptor"", ""Delta opioid receptor"", ""Acetylcholine receptor protein alpha chain"", ""Neuropeptide Y receptor type 1"", ""Neuropeptide Y receptor type 2"", ""Muscarinic acetylcholine receptor M1"", ""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M2"", ""Cysteinyl leukotriene receptor 1"", ""Histamine H1 receptor"", ""Histamine H3 receptor"", ""Histamine H2 receptor"", ""Glucocorticoid receptor"", ""GABA-B receptor 1"", ""Estrogen receptor alpha"", ""Epidermal growth factor receptor erbB1"", ""Endothelin receptor ET-B"", ""Endothelin receptor ET-A"", ""Dopamine D1 receptor"", ""Dopamine D2 receptor"", ""Dopamine D3 receptor"", ""Cannabinoid CB1 receptor"", ""Bradykinin B1 receptor"", ""Bradykinin B2 receptor"", ""Androgen Receptor"", ""Beta-1 adrenergic receptor"", ""Beta-2 adrenergic receptor"", ""Alpha-1d adrenergic receptor"", ""Alpha-2a adrenergic receptor"", ""Adenosine A1 receptor"", ""Adenosine A2a receptor"", ""Adenosine A3 receptor"", ""Metabotropic glutamate receptor 5"")",2915,GRM5,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,cytoplasm IEA GO:0005737 plasma membrane TAS GO:0005886 integral component of plasma membrane IMP 7908515 GO:0005887 postsynaptic density IBA GO:0014069 neuron projection IEA GO:0043005 extracellular exosome IDA 23376485 GO:0070062,"IBA GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway 7908515 TAS GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway 7908515 IMP GO:0007216 G-protein coupled glutamate receptor signaling pathway 7908515 TAS GO:0007268 chemical synaptic transmission IEA GO:0007612 learning IEA GO:0007626 locomotory behavior IEA GO:0048169 regulation of long-term neuronal synaptic plasticity 23227193 IMP GO:0050890 cognition IBA GO:0051966 regulation of synaptic transmission, glutamatergic",G-protein coupled receptor activity GO:0004930 7908515 IMP glutamate receptor activity GO:0008066 7908515 IDA,"hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04540 Gap junction - Homo sapiens (human) hsa04720 Long-term potentiation - Homo sapiens (human) hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04724 Glutamatergic synapse - Homo sapiens (human) hsa05016 Huntington,s disease - Homo sapiens (human)",CHEMBL CHEMBL356310,P55157,Microsomal triglyceride transfer protein large subunit,1.0,PRIMARY,NO,Cc1cccc(C(=O)Nc2ccc3C[C@H](Cc3c2)NCc4ccccn4)c1c5ccc(cc5)C(F)(F)F,2,4,"InChI=1S/C30H26F3N3O/c1-19-5-4-7-27(28(19)20-8-11-23(12-9-20)30(31,32)33)29(37)36-24-13-10-21-15-26(17-22(21)16-24)35-18-25-6-2-3-14-34-25/h2-14,16,26,35H,15,17-18H2,1H3,(H,36,37)/t26-/m1/s1",VFQLHOJNCNGPIK-AREMUKBSSA-N,"c(""Apolipoprotein B-100"", ""Microsomal triglyceride transfer protein large subunit"", ""Unchecked"")",4547,MTP,"Metabolism R-HSA-1430728 Chylomicron-mediated lipid transport R-HSA-174800 Lipoprotein metabolism R-HSA-174824 Metabolism of lipids and lipoproteins R-HSA-556833 Lipid digestion, mobilization, and transport R-HSA-73923",endoplasmic reticulum GO:0005783 IDA 22236406 23475612 26224785 endoplasmic reticulum lumen GO:0005788 TAS receptor complex GO:0043235 IDA 23382219,lipid metabolic process GO:0006629 1439810 TAS phospholipid transport GO:0015914 23475612 26224785 IDA triglyceride transport GO:0034197 22236406 23475612 25108285 26224785 IDA plasma lipoprotein particle assembly GO:0034377 23475612 26224785 IDA lipoprotein biosynthetic process GO:0042158 TAS,lipid transporter activity 22236406 25108285 GO:0005319 IDA lipid transporter activity GO:0005319 TAS protein binding 23475612 25108285 26224785 GO:0005515 IPI phospholipid transporter activity 23475612 26224785 GO:0005548 IDA lipid binding GO:0008289 IEA protein heterodimerization activity 23475612 GO:0046982 IDA,Fat digestion and absorption - Homo sapiens (human) hsa04975,CHEMBL CHEMBL1215331,P08235,Mineralocorticoid receptor,1.0,ORTHOGONAL,NO,OC(=O)c1ccc2C3=NN([C@@H](C4CCCC4)[C@H]3CCc2c1)c5ccc(C#N)c(Cl)c5,4,17,"InChI=1S/C24H22ClN3O2/c25-21-12-18(8-5-17(21)13-26)28-23(14-3-1-2-4-14)20-10-6-15-11-16(24(29)30)7-9-19(15)22(20)27-28/h5,7-9,11-12,14,20,23H,1-4,6,10H2,(H,29,30)/t20-,23-/m0/s1",XNULRSOGWPFPBL-REWPJTCUSA-N,"c(""Mineralocorticoid receptor"", ""Androgen Receptor"", ""Glucocorticoid receptor"", ""Progesterone receptor"", ""Estrogen receptor alpha"", ""Unchecked"")",4306,MCR,R-HSA-212436 Generic Transcription Pathway R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-74160 Gene Expression,TAS GO:0005654 nucleoplasm IEA GO:0005789 endoplasmic reticulum membrane IDA 23382219 receptor complex GO:0043235,"regulation of transcription, DNA-templated GO:0006355 IEA transcription initiation from RNA polymerase II promoter GO:0006367 TAS signal transduction 3037703 GO:0007165 TAS steroid hormone mediated signaling pathway GO:0043401 IEA","GO:0003700 transcription factor activity, sequence-specific DNA binding IEA 9662404 GO:0003707 steroid hormone receptor activity TAS GO:0005496 steroid binding IEA 11518808 GO:0005515 protein binding IPI GO:0008270 zinc ion binding IEA GO:0043565 sequence-specific DNA binding IEA",hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human),CHEMBL CHEMBL273453,P08235,Mineralocorticoid receptor,1.0,PRIMARY,NO,C[C@]12CCC(=O)C=C1CC[C@H]3[C@@H]4CC[C@H](C(=O)CO)[C@]4(C[C@H](O)[C@H]23)C=O,6,28,"InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1",PQSUYGKTWSAVDQ-ZVIOFETBSA-N,"c(""Corticosteroid binding globulin"", ""Testis-specific androgen-binding protein"", ""Monoclonal antibody (mAb)"", ""Progesterone receptor"", ""Mineralocorticoid receptor"", ""Glucocorticoid receptor"", ""Unchecked"", ""3-keto-steroid reductase"", ""Nuclear factor erythroid 2-related factor 2"", ""Androgen Receptor"", ""Thyroid hormone receptor beta-1"", ""Solute carrier family 22 member 5"", ""Geminin"", ""Guanine nucleotide-binding protein G(s), subunit alpha"")",4306,MCR,R-HSA-212436 Generic Transcription Pathway R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-74160 Gene Expression,TAS GO:0005654 nucleoplasm IEA GO:0005789 endoplasmic reticulum membrane IDA 23382219 receptor complex GO:0043235,"regulation of transcription, DNA-templated GO:0006355 IEA transcription initiation from RNA polymerase II promoter GO:0006367 TAS signal transduction 3037703 GO:0007165 TAS steroid hormone mediated signaling pathway GO:0043401 IEA","GO:0003700 transcription factor activity, sequence-specific DNA binding IEA 9662404 GO:0003707 steroid hormone receptor activity TAS GO:0005496 steroid binding IEA 11518808 GO:0005515 protein binding IPI GO:0008270 zinc ion binding IEA GO:0043565 sequence-specific DNA binding IEA",hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human),CHEMBL CHEMBL2408616,O43318,Mitogen-activated protein kinase kinase kinase 7,1.0,PRIMARY,NO,Nc1ncc(c2cnn(c2)[C@@H]3CC[C@@H](O)CC3)c4c(C(F)F)c(oc14)c5cccc6nnsc56,7,8,"InChI=1S/C23H20F2N6O2S/c24-22(25)18-17-15(11-8-28-31(10-11)12-4-6-13(32)7-5-12)9-27-23(26)20(17)33-19(18)14-2-1-3-16-21(14)34-30-29-16/h1-3,8-10,12-13,22,32H,4-7H2,(H2,26,27)/t12-,13-",CQMWAJCVQYHQCJ-JOCQHMNTSA-N,"c(""Vascular endothelial growth factor receptor 2"", ""Misshapen-like kinase 1"", ""Mitogen-activated protein kinase kinase kinase kinase 5"", ""Mitogen-activated protein kinase kinase kinase kinase 4"", ""Tyrosine-protein kinase receptor FLT3"", ""Serine/threonine-protein kinase Aurora-B"", ""Mitogen-activated protein kinase kinase kinase 7"", ""TAK1/TAB1"")",6885,M3K7,"Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 Activation of NF-kappaB in B cells R-HSA-1169091 Cytokine Signaling in Immune system R-HSA-1280215 Adaptive Immune System R-HSA-1280218 Signal Transduction R-HSA-162582 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166016 Activated TLR4 signalling R-HSA-166054 MyD88:Mal cascade initiated on plasma membrane R-HSA-166058 MyD88-independent TLR3/TLR4 cascade R-HSA-166166 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168142 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168164 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168176 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168179 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168180 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168188 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 NOD1/2 Signaling Pathway R-HSA-168638 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168643 Toll-Like Receptors Cascades R-HSA-168898 Toll Like Receptor 2 (TLR2) Cascade R-HSA-181438 Signaling by Wnt R-HSA-195721 TCR signaling R-HSA-202403 Downstream TCR signaling R-HSA-202424 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 FCERI mediated NF-kB activation R-HSA-2871837 beta-catenin independent WNT signaling R-HSA-3858494 Ca2+ pathway R-HSA-4086398 TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-445989 Interleukin-1 signaling R-HSA-446652 Signaling by Interleukins R-HSA-449147 MAP kinase activation in TLR cascade R-HSA-450294 activated TAK1 mediates p38 MAPK activation R-HSA-450302 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450321 CLEC7A (Dectin-1) signaling R-HSA-5607764 C-type lectin receptors (CLRs) R-HSA-5621481 IRAK2 mediated activation of TAK1 complex R-HSA-937042 TRIF-mediated TLR3/TLR4 signaling R-HSA-937061 TRAF6 mediated induction of TAK1 complex R-HSA-937072 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 MyD88 dependent cascade initiated on endosome R-HSA-975155 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation R-HSA-975163 MyD88 cascade initiated on plasma membrane R-HSA-975871 Signaling by the B Cell Receptor (BCR) R-HSA-983705",nucleus GO:0005634 21630459 IDA Ada2/Gcn5/Ada3 transcription activator complex GO:0005671 18838386 IDA cytoplasm GO:0005737 IDA cytosol GO:0005829 TAS plasma membrane GO:0005886 IEA IkappaB kinase complex GO:0008385 10094049 IPI colocalizes_with endosome membrane GO:0010008 TAS,"8663074 9079627 GO:0000186 activation of MAPKK activity IDA 9079627 GO:0000187 activation of MAPK activity IDA GO:0000187 activation of MAPK activity TAS GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS 15125833 GO:0002726 positive regulation of T cell cytokine production IMP GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS GO:0006351 transcription, DNA-templated IEA GO:0006915 apoptotic process IEA 9466656 GO:0007179 transforming growth factor beta receptor signaling pathway TAS GO:0007223 Wnt signaling pathway, calcium modulating pathway TAS GO:0007249 I-kappaB kinase/NF-kappaB signaling TAS 10094049 15125833 GO:0007250 activation of NF-kappaB-inducing kinase activity IMP 11460167 GO:0007252 I-kappaB phosphorylation IDA 9079627 GO:0007254 JNK cascade IDA GO:0007254 JNK cascade TAS 15125833 GO:0032743 positive regulation of interleukin-2 production IMP GO:0038095 Fc-epsilon receptor signaling pathway TAS 14982987 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP 11460167 GO:0043507 positive regulation of JUN kinase activity IDA 10094049 GO:0043507 positive regulation of JUN kinase activity IMP 18838386 GO:0043966 histone H3 acetylation IDA 15125833 GO:0050852 T cell receptor signaling pathway NAS GO:0050852 T cell receptor signaling pathway TAS 15125833 GO:0050870 positive regulation of T cell activation IC GO:0051092 positive regulation of NF-kappaB transcription factor activity TAS 9079627 GO:0051403 stress-activated MAPK cascade IDA GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS",magnesium ion binding IEA GO:0000287 protein kinase activity IDA 10094049 GO:0004672 protein serine/threonine kinase activity EXP 10702308 11460167 20538596 GO:0004674 protein serine/threonine kinase activity TAS GO:0004674 MAP kinase kinase kinase activity EXP 11460167 GO:0004709 MAP kinase kinase kinase activity IDA 11460167 GO:0004709 protein binding IPI 10094049 11460167 12496252 15075345 15764709 16840345 16845370 17079228 17110930 17158449 17449468 17709393 18286207 18591963 18758450 19820695 21512573 21903422 22081109 25241761 GO:0005515 ATP binding IEA GO:0005524 scaffold protein binding IDA 23776175 GO:0097110,hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04064 NF-kappa B signaling pathway - Homo sapiens (human) hsa04152 AMPK signaling pathway - Homo sapiens (human) hsa04310 Wnt signaling pathway - Homo sapiens (human) hsa04380 Osteoclast differentiation - Homo sapiens (human) hsa04520 Adherens junction - Homo sapiens (human) hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human) hsa04622 RIG-I-like receptor signaling pathway - Homo sapiens (human) hsa04660 T cell receptor signaling pathway - Homo sapiens (human) hsa04668 TNF signaling pathway - Homo sapiens (human) hsa05140 Leishmaniasis - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05162 Measles - Homo sapiens (human) hsa05168 Herpes simplex infection - Homo sapiens (human) hsa05169 Epstein-Barr virus infection - Homo sapiens (human),CHEMBL CHEMBL491228,P41279,Mitogen-activated protein kinase kinase kinase 8,1.0,PRIMARY,NO,NC(=O)c1ccc(cc1)c2ccc(Oc3cncc4sc(cc34)c5nn[nH]n5)cc2,2,3,"InChI=1S/C21H14N6O2S/c22-20(28)14-3-1-12(2-4-14)13-5-7-15(8-6-13)29-17-10-23-11-19-16(17)9-18(30-19)21-24-26-27-25-21/h1-11H,(H2,22,28)(H,24,25,26,27)",NCPSMBVBKJXJPP-UHFFFAOYSA-N,"c(""Mitogen-activated protein kinase kinase kinase 8"", ""Dual specificity mitogen-activated protein kinase kinase 1"")",1326,M3K8,R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166054 Activated TLR4 signalling R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-166166 MyD88-independent TLR3/TLR4 cascade R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168180 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-168898 Toll-Like Receptors Cascades R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-388841 Costimulation by the CD28 family R-HSA-389356 CD28 co-stimulation R-HSA-389357 CD28 dependent PI3K/Akt signaling R-HSA-446652 Interleukin-1 signaling R-HSA-449147 Signaling by Interleukins R-HSA-450294 MAP kinase activation in TLR cascade R-HSA-937061 TRIF-mediated TLR3/TLR4 signaling R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-975871 MyD88 cascade initiated on plasma membrane,cytoplasm GO:0005737 IDA cytosol GO:0005829 TAS,activation of MAPKK activity IEA GO:0000186 protein phosphorylation TAS 2072910 GO:0006468 apoptotic process IBA GO:0006915 cell cycle IEA GO:0007049 T cell costimulation TAS GO:0031295 stress-activated MAPK cascade TAS GO:0051403,GO:0000287 magnesium ion binding IEA GO:0004674 protein serine/threonine kinase activity 8226782 TAS GO:0004702 receptor signaling protein serine/threonine kinase activity IBA GO:0004709 MAP kinase kinase kinase activity TAS GO:0005515 protein binding 12832462 14743216 15169888 21988832 22939624 24265246 25609649 25852190 IPI GO:0005524 ATP binding IEA,MAPK signaling pathway - Homo sapiens (human) hsa04010 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04620 T cell receptor signaling pathway - Homo sapiens (human) hsa04660 TNF signaling pathway - Homo sapiens (human) hsa04668,CHEMBL CHEMBL517743,P80192,Mitogen-activated protein kinase kinase kinase 9,1.0,PRIMARY,NO,OCCn1c2ccccc2c3c4CNC(=O)c4c5c(CCc6cc(OC7CCCC7)ccc56)c13,2,3,"InChI=1S/C29H28N2O3/c32-14-13-31-24-8-4-3-7-21(24)26-23-16-30-29(33)27(23)25-20-12-10-19(34-18-5-1-2-6-18)15-17(20)9-11-22(25)28(26)31/h3-4,7-8,10,12,15,18,32H,1-2,5-6,9,11,13-14,16H2,(H,30,33)",FNZIPRHNOOCRHH-UHFFFAOYSA-N,"c(""Mitogen-activated protein kinase kinase kinase 9"", ""Mitogen-activated protein kinase kinase kinase 11"")",4293,M3K9,,cellular_component ND GO:0005575 intracellular IEA GO:0005622,"transcription, DNA-templated GO:0006351 IEA regulation of transcription, DNA-templated GO:0006355 IEA protein phosphorylation GO:0006468 15610029 IDA apoptotic process GO:0006915 IEA activation of JNKK activity GO:0007256 IEA activation of JUN kinase activity GO:0007257 8195146 ISS positive regulation of apoptotic process GO:0043065 IEA protein autophosphorylation GO:0046777 15610029 IDA",15610029 IDA GO:0004674 protein serine/threonine kinase activity ISS GO:0004706 JUN kinase kinase kinase activity 8477742 NAS GO:0004708 MAP kinase kinase activity 22939624 IPI GO:0005515 protein binding IEA GO:0005524 ATP binding 8195146 ISS GO:0042803 protein homodimerization activity,,CHEMBL CHEMBL3613671,Q9BV23,Monoacylglycerol lipase ABHD6,1.0,ORTHOGONAL,NO,CN(C1CCCCCCC1)C(=O)Oc2nsnc2N3CCOCC3,2,6,"InChI=1S/C16H26N4O3S/c1-19(13-7-5-3-2-4-6-8-13)16(21)23-15-14(17-24-18-15)20-9-11-22-12-10-20/h13H,2-12H2,1H3",WKSHMJCYWFOADB-UHFFFAOYSA-N,"c(""Anandamide amidohydrolase"", ""Monoacylglycerol lipase ABHD6"")",57406,ABHD6,,GO:0005739 mitochondrion IBA GO:0005886 plasma membrane TAS GO:0016021 integral component of membrane ISS GO:0032281 AMPA glutamate receptor complex IEA 23376485 GO:0070062 extracellular exosome IDA,GO:0009395 phospholipid catabolic process IEA GO:0030336 negative regulation of cell migration IEA GO:0046464 acylglycerol catabolic process 22969151 IDA GO:0046889 positive regulation of lipid biosynthetic process IEA GO:0060292 long term synaptic depression IEA GO:2000124 regulation of endocannabinoid signaling pathway IEA,phospholipase activity GO:0004620 IBA acylglycerol lipase activity GO:0047372 IDA 22969151 acylglycerol lipase activity GO:0047372 TAS,hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human),CHEMBL CHEMBL3613162,Q9BV23,Monoacylglycerol lipase ABHD6,1.0,PRIMARY,NO,Nc1cccc(CN2N=C(Oc3ccccc3)OC2=O)c1,3,3,"InChI=1S/C15H13N3O3/c16-12-6-4-5-11(9-12)10-18-15(19)21-14(17-18)20-13-7-2-1-3-8-13/h1-9H,10,16H2",XBXJIQLJWDYRGA-UHFFFAOYSA-N,"c(""Anandamide amidohydrolase"", ""Monoglyceride lipase"", ""Monoacylglycerol lipase ABHD6"")",57406,ABHD6,,GO:0005739 mitochondrion IBA GO:0005886 plasma membrane TAS GO:0016021 integral component of membrane ISS GO:0032281 AMPA glutamate receptor complex IEA 23376485 GO:0070062 extracellular exosome IDA,GO:0009395 phospholipid catabolic process IEA GO:0030336 negative regulation of cell migration IEA GO:0046464 acylglycerol catabolic process 22969151 IDA GO:0046889 positive regulation of lipid biosynthetic process IEA GO:0060292 long term synaptic depression IEA GO:2000124 regulation of endocannabinoid signaling pathway IEA,phospholipase activity GO:0004620 IBA acylglycerol lipase activity GO:0047372 IDA 22969151 acylglycerol lipase activity GO:0047372 TAS,hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human),CHEMBL CHEMBL470226,P27338,Monoamine oxidase B,1.0,ORTHOGONAL,NO,CS(=O)(=O)c1ccc(NC(=O)C2=Cc3ccccc3OC2=O)cc1,2,3,"InChI=1S/C17H13NO5S/c1-24(21,22)13-8-6-12(7-9-13)18-16(19)14-10-11-4-2-3-5-15(11)23-17(14)20/h2-10H,1H3,(H,18,19)",QJBHODZBXYTRMA-UHFFFAOYSA-N,"c(""Monoamine oxidase A"", ""Monoamine oxidase B"", ""Unchecked"")",4129,AOFB,R-HSA-140179 Amine Oxidase reactions R-HSA-141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB R-HSA-1430728 Metabolism R-HSA-211859 Biological oxidations R-HSA-211945 Phase 1 - Functionalization of compounds,GO:0005739 mitochondrion 20833797 IDA GO:0005740 mitochondrial envelope 7063850 TAS GO:0005741 mitochondrial outer membrane 24252804 TAS GO:0005743 mitochondrial inner membrane IEA GO:0016021 integral component of membrane IEA GO:0070062 extracellular exosome 23376485 IDA,response to toxic substance GO:0009636 IEA response to aluminum ion GO:0010044 IEA response to selenium ion GO:0010269 IEA negative regulation of serotonin secretion GO:0014063 IEA substantia nigra development GO:0021762 IEP 22926577 response to lipopolysaccharide GO:0032496 IEA dopamine catabolic process GO:0042420 TAS 24252804 response to drug GO:0042493 IEA response to ethanol GO:0045471 IEA positive regulation of dopamine metabolic process GO:0045964 IEA hydrogen peroxide biosynthetic process GO:0050665 NAS 24252804 response to corticosterone GO:0051412 IEA oxidation-reduction process GO:0055114 IEA,TAS GO:0008131 primary amine oxidase activity TAS 8602220 electron carrier activity GO:0009055 IEA GO:0042803 protein homodimerization activity IEA GO:0050660 flavin adenine dinucleotide binding,"Glycine, serine and threonine metabolism - Homo sapiens (human) hsa00260 Arginine and proline metabolism - Homo sapiens (human) hsa00330 Histidine metabolism - Homo sapiens (human) hsa00340 Tyrosine metabolism - Homo sapiens (human) hsa00350 Phenylalanine metabolism - Homo sapiens (human) hsa00360 Tryptophan metabolism - Homo sapiens (human) hsa00380 Drug metabolism - cytochrome P450 - Homo sapiens (human) hsa00982 Serotonergic synapse - Homo sapiens (human) hsa04726 Dopaminergic synapse - Homo sapiens (human) hsa04728 Cocaine addiction - Homo sapiens (human) hsa05030 Amphetamine addiction - Homo sapiens (human) hsa05031 Alcoholism - Homo sapiens (human) hsa05034",CHEMBL CHEMBL3360732,P27338,Monoamine oxidase B,1.0,PRIMARY,NO,Cc1ccc2OC(=O)C(=Cc2c1)c3ccc(cc3)[N+](=O)[O-],2,4,"InChI=1S/C16H11NO4/c1-10-2-7-15-12(8-10)9-14(16(18)21-15)11-3-5-13(6-4-11)17(19)20/h2-9H,1H3",XGJDMHWEDXLYCE-UHFFFAOYSA-N,"c(""Monoamine oxidase A"", ""Monoamine oxidase B"", ""Unchecked"")",4129,AOFB,R-HSA-140179 Amine Oxidase reactions R-HSA-141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB R-HSA-1430728 Metabolism R-HSA-211859 Biological oxidations R-HSA-211945 Phase 1 - Functionalization of compounds,GO:0005739 mitochondrion 20833797 IDA GO:0005740 mitochondrial envelope 7063850 TAS GO:0005741 mitochondrial outer membrane 24252804 TAS GO:0005743 mitochondrial inner membrane IEA GO:0016021 integral component of membrane IEA GO:0070062 extracellular exosome 23376485 IDA,response to toxic substance GO:0009636 IEA response to aluminum ion GO:0010044 IEA response to selenium ion GO:0010269 IEA negative regulation of serotonin secretion GO:0014063 IEA substantia nigra development GO:0021762 IEP 22926577 response to lipopolysaccharide GO:0032496 IEA dopamine catabolic process GO:0042420 TAS 24252804 response to drug GO:0042493 IEA response to ethanol GO:0045471 IEA positive regulation of dopamine metabolic process GO:0045964 IEA hydrogen peroxide biosynthetic process GO:0050665 NAS 24252804 response to corticosterone GO:0051412 IEA oxidation-reduction process GO:0055114 IEA,TAS GO:0008131 primary amine oxidase activity TAS 8602220 electron carrier activity GO:0009055 IEA GO:0042803 protein homodimerization activity IEA GO:0050660 flavin adenine dinucleotide binding,"Glycine, serine and threonine metabolism - Homo sapiens (human) hsa00260 Arginine and proline metabolism - Homo sapiens (human) hsa00330 Histidine metabolism - Homo sapiens (human) hsa00340 Tyrosine metabolism - Homo sapiens (human) hsa00350 Phenylalanine metabolism - Homo sapiens (human) hsa00360 Tryptophan metabolism - Homo sapiens (human) hsa00380 Drug metabolism - cytochrome P450 - Homo sapiens (human) hsa00982 Serotonergic synapse - Homo sapiens (human) hsa04726 Dopaminergic synapse - Homo sapiens (human) hsa04728 Cocaine addiction - Homo sapiens (human) hsa05030 Amphetamine addiction - Homo sapiens (human) hsa05031 Alcoholism - Homo sapiens (human) hsa05034",CHEMBL CHEMBL3087181,Q99685,Monoglyceride lipase,1.0,ORTHOGONAL,NO,O=C(N1CCC(CC1)C(c2ccc3OCOc3c2)c4ccc5OCOc5c4)n6cncn6,2,5,"InChI=1S/C23H22N4O5/c28-23(27-12-24-11-25-27)26-7-5-15(6-8-26)22(16-1-3-18-20(9-16)31-13-29-18)17-2-4-19-21(10-17)32-14-30-19/h1-4,9-12,15,22H,5-8,13-14H2",CLSNATLUIXZPMV-UHFFFAOYSA-N,"c(""Monoglyceride lipase"", ""Anandamide amidohydrolase"", ""Unchecked"")",11343,MGLL,"R-HSA-109582 Hemostasis R-HSA-114508 Effects of PIP2 hydrolysis R-HSA-1430728 Metabolism R-HSA-1482883 Acyl chain remodeling of DAG and TAG R-HSA-1483206 Glycerophospholipid biosynthesis R-HSA-1483257 Phospholipid metabolism R-HSA-162582 Signal Transduction R-HSA-163560 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis R-HSA-372790 Signaling by GPCR R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-426048 Arachidonate production from DAG R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-73923 Lipid digestion, mobilization, and transport R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK",nucleoplasm GO:0005654 IDA endoplasmic reticulum membrane GO:0005789 TAS cytosol GO:0005829 ISS plasma membrane GO:0005886 TAS membrane GO:0016020 IBA extrinsic component of membrane GO:0019898 ISS,TAS 9495531 lipid metabolic process GO:0006629 IEA GO:0006633 fatty acid biosynthetic process TAS 9495531 inflammatory response GO:0006954 IBA GO:0009966 regulation of signal transduction ISS GO:0009966 regulation of signal transduction ISS GO:0019369 arachidonic acid metabolic process IEA GO:0019433 triglyceride catabolic process TAS GO:0036155 acylglycerol acyl-chain remodeling IDA 22969151 acylglycerol catabolic process GO:0046464 ISS GO:0046464 acylglycerol catabolic process ISS GO:0050727 regulation of inflammatory response ISS GO:0051930 regulation of sensory perception of pain ISS GO:2000124 regulation of endocannabinoid signaling pathway,9495531 TAS GO:0004622 lysophospholipase activity 19957260 IPI GO:0042803 protein homodimerization activity 22969151 IDA GO:0047372 acylglycerol lipase activity ISS GO:0047372 acylglycerol lipase activity TAS GO:0047372 acylglycerol lipase activity,Glycerolipid metabolism - Homo sapiens (human) hsa00561 Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04723 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04923,CHEMBL CHEMBL3401455,Q99685,Monoglyceride lipase,1.0,PRIMARY,NO,Clc1ccc2C(=C3CCN(CC3)C(=O)n4cncn4)c5ncccc5CCc2c1,3,13,"InChI=1S/C22H20ClN5O/c23-18-5-6-19-17(12-18)4-3-16-2-1-9-25-21(16)20(19)15-7-10-27(11-8-15)22(29)28-14-24-13-26-28/h1-2,5-6,9,12-14H,3-4,7-8,10-11H2",GAVZCGTYRWKKDV-UHFFFAOYSA-N,"c(""Anandamide amidohydrolase"", ""Monoglyceride lipase"", ""Monoacylglycerol lipase ABHD6"", ""Unchecked"", ""Cannabinoid CB2 receptor"")",11343,MGLL,"R-HSA-109582 Hemostasis R-HSA-114508 Effects of PIP2 hydrolysis R-HSA-1430728 Metabolism R-HSA-1482883 Acyl chain remodeling of DAG and TAG R-HSA-1483206 Glycerophospholipid biosynthesis R-HSA-1483257 Phospholipid metabolism R-HSA-162582 Signal Transduction R-HSA-163560 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis R-HSA-372790 Signaling by GPCR R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-426048 Arachidonate production from DAG R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-73923 Lipid digestion, mobilization, and transport R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK",nucleoplasm GO:0005654 IDA endoplasmic reticulum membrane GO:0005789 TAS cytosol GO:0005829 ISS plasma membrane GO:0005886 TAS membrane GO:0016020 IBA extrinsic component of membrane GO:0019898 ISS,TAS 9495531 lipid metabolic process GO:0006629 IEA GO:0006633 fatty acid biosynthetic process TAS 9495531 inflammatory response GO:0006954 IBA GO:0009966 regulation of signal transduction ISS GO:0009966 regulation of signal transduction ISS GO:0019369 arachidonic acid metabolic process IEA GO:0019433 triglyceride catabolic process TAS GO:0036155 acylglycerol acyl-chain remodeling IDA 22969151 acylglycerol catabolic process GO:0046464 ISS GO:0046464 acylglycerol catabolic process ISS GO:0050727 regulation of inflammatory response ISS GO:0051930 regulation of sensory perception of pain ISS GO:2000124 regulation of endocannabinoid signaling pathway,9495531 TAS GO:0004622 lysophospholipase activity 19957260 IPI GO:0042803 protein homodimerization activity 22969151 IDA GO:0047372 acylglycerol lipase activity ISS GO:0047372 acylglycerol lipase activity TAS GO:0047372 acylglycerol lipase activity,Glycerolipid metabolism - Homo sapiens (human) hsa00561 Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04723 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04923,CHEMBL CHEMBL197,P33527,Multidrug resistance-associated protein 1,1.0,PRIMARY,NO,COc1ccc(CCN(C)CCC[C@@](C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC,3,14,"InChI=1S/C27H38N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,8,13-16H2,1-7H3/t27-/m1/s1",SGTNSNPWRIOYBX-HHHXNRCGSA-N,"c(""P-glycoprotein 1"", ""Multidrug resistance-associated protein 1"", ""Prelamin-A/C"", ""Huntingtin"", ""Microtubule-associated protein tau"", ""Lysosomal alpha-glucosidase"", ""Beta-glucocerebrosidase"", ""Unchecked"")",4363,MRP1,"Metabolism R-HSA-1430728 Cobalamin (Cbl, vitamin B12) transport and metabolism R-HSA-196741 Metabolism of water-soluble vitamins and cofactors R-HSA-196849 Metabolism of vitamins and cofactors R-HSA-196854 Synthesis of Leukotrienes (LT) and Eoxins (EX) R-HSA-2142691 Arachidonic acid metabolism R-HSA-2142753 Transmembrane transport of small molecules R-HSA-382551 ABC-family proteins mediated transport R-HSA-382556 Metabolism of lipids and lipoproteins R-HSA-556833",IDA GO:0005886 plasma membrane TAS GO:0005886 plasma membrane IEA GO:0005887 integral component of plasma membrane IDA 19946888 membrane GO:0016020 IDA 24130369 basolateral plasma membrane GO:0016323 IDA 20458337 extracellular exosome GO:0070062,TAS GO:0006691 leukotriene metabolic process 1360704 TAS GO:0006810 transport TAS GO:0009235 cobalamin metabolic process IEA GO:0015889 cobalamin transport IEA GO:0035461 vitamin transmembrane transport 1360704 TAS GO:0042493 response to drug TAS GO:0055085 transmembrane transport IEA GO:0098656 anion transmembrane transport,"transporter activity GO:0005215 1360704 TAS ATP binding GO:0005524 IEA cobalamin-transporting ATPase activity GO:0015420 TAS ATPase activity GO:0016887 15999530 IDA ATPase activity, coupled to transmembrane movement of substances GO:0042626 TAS anion transmembrane-transporting ATPase activity GO:0043225 TAS",hsa02010 ABC transporters - Homo sapiens (human) hsa04071 Sphingolipid signaling pathway - Homo sapiens (human) hsa04977 Vitamin digestion and absorption - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human),CHEMBL CHEMBL3216999,P35372,Mu opioid receptor,1.0,ORTHOGONAL,NO,Cl.Cl.CCOc1ccc(Cc2nc3cc(NC(=N)c4cccs4)ccc3n2CCN(CC)CC)cc1,4,7,"InChI=1S/C27H33N5OS.2ClH/c1-4-31(5-2)15-16-32-24-14-11-21(29-27(28)25-8-7-17-34-25)19-23(24)30-26(32)18-20-9-12-22(13-10-20)33-6-3;;/h7-14,17,19H,4-6,15-16,18H2,1-3H3,(H2,28,29);2*1H",NMXHCRDZUHHHIS-UHFFFAOYSA-N,"c(""Nitric-oxide synthase, brain"", ""Nitric-oxide synthase, endothelial"", ""Nitric oxide synthase, inducible"", ""Mu opioid receptor"", ""Unchecked"")",4988,OPRM,R-HSA-111885 Opioid Signalling R-HSA-162582 Signal Transduction R-HSA-202040 G-protein activation R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,9242668 TAS GO:0005783 endoplasmic reticulum 9242668 TAS GO:0005794 Golgi apparatus TAS GO:0005886 plasma membrane 7905839 TAS GO:0005887 integral component of plasma membrane IEA GO:0005925 focal adhesion IEA GO:0032590 dendrite membrane IEA GO:0032839 dendrite cytoplasm IEA GO:0042383 sarcolemma IBA GO:0043005 neuron projection IEA GO:0043204 perikaryon IEA GO:0045121 membrane raft IEA GO:0098794 postsynapse,"acute inflammatory response to antigenic stimulus GO:0002438 IEA G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 7905839 TAS adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 IEA negative regulation of adenylate cyclase activity GO:0007194 ISS phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 ISS neuropeptide signaling pathway GO:0007218 IEA chemical synaptic transmission GO:0007268 IBA sensory perception GO:0007600 9689128 NAS locomotory behavior GO:0007626 IEA negative regulation of cell proliferation GO:0008285 2159143 TAS response to radiation GO:0009314 IEA sensory perception of pain GO:0019233 IBA sensory perception of pain GO:0019233 ISS adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 IEA response to food GO:0032094 IEA positive regulation of appetite GO:0032100 IEA response to lipopolysaccharide GO:0032496 IEA cellular response to stress GO:0033554 21039637 IMP wound healing GO:0042060 IEA response to cocaine GO:0042220 IEA eating behavior GO:0042755 IEA estrous cycle GO:0044849 IEA behavioral response to ethanol GO:0048149 21039637 IMP positive regulation of neurogenesis GO:0050769 ISS regulation of sensory perception of pain GO:0051930 IEA excitatory postsynaptic potential GO:0060079 IEA negative regulation of Wnt protein secretion GO:0061358 20214800 IMP positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS calcium ion transmembrane transport GO:0070588 IEA response to growth factor GO:0070848 IEA cellular response to morphine GO:0071315 IBA regulation of N-methyl-D-aspartate selective glutamate receptor activity GO:2000310 ISS",G-protein alpha-subunit binding 20214800 GO:0001965 IDA G-protein coupled receptor activity GO:0004930 ISS beta-endorphin receptor activity 9689128 GO:0004979 IMP voltage-gated calcium channel activity GO:0005245 ISS protein binding 14573758 19788913 20214800 23597562 23840749 GO:0005515 IPI protein C-terminus binding GO:0008022 IEA protein domain specific binding GO:0019904 IEA filamin binding GO:0031005 IEA G-protein beta-subunit binding GO:0031681 IBA morphine receptor activity GO:0038047 IBA morphine receptor activity GO:0038047 ISS neuropeptide binding GO:0042923 IBA,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Estrogen signaling pathway - Homo sapiens (human) hsa04915 Morphine addiction - Homo sapiens (human) hsa05032,CHEMBL CHEMBL1400,P35372,Mu opioid receptor,1.0,PRIMARY,NO,CN(C)C[C@H]1CCCC[C@]1(O)c2cccc(O)c2,5,13,"InChI=1S/C15H23NO2/c1-16(2)11-13-6-3-4-9-15(13,18)12-7-5-8-14(17)10-12/h5,7-8,10,13,17-18H,3-4,6,9,11H2,1-2H3/t13-,15+/m1/s1",UWJUQVWARXYRCG-HIFRSBDPSA-N,"c(""Mu opioid receptor"", ""Serotonin transporter"", ""Norepinephrine transporter"", ""Kappa opioid receptor"", ""Delta opioid receptor"", ""Unchecked"", ""Menin/Histone-lysine N-methyltransferase MLL"")",4988,OPRM,R-HSA-111885 Opioid Signalling R-HSA-162582 Signal Transduction R-HSA-202040 G-protein activation R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,9242668 TAS GO:0005783 endoplasmic reticulum 9242668 TAS GO:0005794 Golgi apparatus TAS GO:0005886 plasma membrane 7905839 TAS GO:0005887 integral component of plasma membrane IEA GO:0005925 focal adhesion IEA GO:0032590 dendrite membrane IEA GO:0032839 dendrite cytoplasm IEA GO:0042383 sarcolemma IBA GO:0043005 neuron projection IEA GO:0043204 perikaryon IEA GO:0045121 membrane raft IEA GO:0098794 postsynapse,"acute inflammatory response to antigenic stimulus GO:0002438 IEA G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 7905839 TAS adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 IEA negative regulation of adenylate cyclase activity GO:0007194 ISS phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 ISS neuropeptide signaling pathway GO:0007218 IEA chemical synaptic transmission GO:0007268 IBA sensory perception GO:0007600 9689128 NAS locomotory behavior GO:0007626 IEA negative regulation of cell proliferation GO:0008285 2159143 TAS response to radiation GO:0009314 IEA sensory perception of pain GO:0019233 IBA sensory perception of pain GO:0019233 ISS adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 IEA response to food GO:0032094 IEA positive regulation of appetite GO:0032100 IEA response to lipopolysaccharide GO:0032496 IEA cellular response to stress GO:0033554 21039637 IMP wound healing GO:0042060 IEA response to cocaine GO:0042220 IEA eating behavior GO:0042755 IEA estrous cycle GO:0044849 IEA behavioral response to ethanol GO:0048149 21039637 IMP positive regulation of neurogenesis GO:0050769 ISS regulation of sensory perception of pain GO:0051930 IEA excitatory postsynaptic potential GO:0060079 IEA negative regulation of Wnt protein secretion GO:0061358 20214800 IMP positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS calcium ion transmembrane transport GO:0070588 IEA response to growth factor GO:0070848 IEA cellular response to morphine GO:0071315 IBA regulation of N-methyl-D-aspartate selective glutamate receptor activity GO:2000310 ISS",G-protein alpha-subunit binding 20214800 GO:0001965 IDA G-protein coupled receptor activity GO:0004930 ISS beta-endorphin receptor activity 9689128 GO:0004979 IMP voltage-gated calcium channel activity GO:0005245 ISS protein binding 14573758 19788913 20214800 23597562 23840749 GO:0005515 IPI protein C-terminus binding GO:0008022 IEA protein domain specific binding GO:0019904 IEA filamin binding GO:0031005 IEA G-protein beta-subunit binding GO:0031681 IBA morphine receptor activity GO:0038047 IBA morphine receptor activity GO:0038047 ISS neuropeptide binding GO:0042923 IBA,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Estrogen signaling pathway - Homo sapiens (human) hsa04915 Morphine addiction - Homo sapiens (human) hsa05032,CHEMBL CHEMBL2443262,P35372,Mu opioid receptor,1.0,ORTHOGONAL,YES,COc1ccsc1CNCC[C@]2(CCOC3(CCCC3)C2)c4ccccn4,3,16,"InChI=1S/C22H30N2O2S/c1-25-18-7-15-27-19(18)16-23-13-10-21(20-6-2-5-12-24-20)11-14-26-22(17-21)8-3-4-9-22/h2,5-7,12,15,23H,3-4,8-11,13-14,16-17H2,1H3/t21-/m1/s1",DMNOVGJWPASQDL-OAQYLSRUSA-N,"c(""Mu opioid receptor"", ""Sodium channel protein type V alpha subunit"", ""Unchecked"", ""Delta opioid receptor"", ""Kappa opioid receptor"", ""Voltage-gated L-type calcium channel alpha-1C subunit"")",4988,OPRM,R-HSA-111885 Opioid Signalling R-HSA-162582 Signal Transduction R-HSA-202040 G-protein activation R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,9242668 TAS GO:0005783 endoplasmic reticulum 9242668 TAS GO:0005794 Golgi apparatus TAS GO:0005886 plasma membrane 7905839 TAS GO:0005887 integral component of plasma membrane IEA GO:0005925 focal adhesion IEA GO:0032590 dendrite membrane IEA GO:0032839 dendrite cytoplasm IEA GO:0042383 sarcolemma IBA GO:0043005 neuron projection IEA GO:0043204 perikaryon IEA GO:0045121 membrane raft IEA GO:0098794 postsynapse,"acute inflammatory response to antigenic stimulus GO:0002438 IEA G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 7905839 TAS adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 IEA negative regulation of adenylate cyclase activity GO:0007194 ISS phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 ISS neuropeptide signaling pathway GO:0007218 IEA chemical synaptic transmission GO:0007268 IBA sensory perception GO:0007600 9689128 NAS locomotory behavior GO:0007626 IEA negative regulation of cell proliferation GO:0008285 2159143 TAS response to radiation GO:0009314 IEA sensory perception of pain GO:0019233 IBA sensory perception of pain GO:0019233 ISS adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 IEA response to food GO:0032094 IEA positive regulation of appetite GO:0032100 IEA response to lipopolysaccharide GO:0032496 IEA cellular response to stress GO:0033554 21039637 IMP wound healing GO:0042060 IEA response to cocaine GO:0042220 IEA eating behavior GO:0042755 IEA estrous cycle GO:0044849 IEA behavioral response to ethanol GO:0048149 21039637 IMP positive regulation of neurogenesis GO:0050769 ISS regulation of sensory perception of pain GO:0051930 IEA excitatory postsynaptic potential GO:0060079 IEA negative regulation of Wnt protein secretion GO:0061358 20214800 IMP positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS calcium ion transmembrane transport GO:0070588 IEA response to growth factor GO:0070848 IEA cellular response to morphine GO:0071315 IBA regulation of N-methyl-D-aspartate selective glutamate receptor activity GO:2000310 ISS",G-protein alpha-subunit binding 20214800 GO:0001965 IDA G-protein coupled receptor activity GO:0004930 ISS beta-endorphin receptor activity 9689128 GO:0004979 IMP voltage-gated calcium channel activity GO:0005245 ISS protein binding 14573758 19788913 20214800 23597562 23840749 GO:0005515 IPI protein C-terminus binding GO:0008022 IEA protein domain specific binding GO:0019904 IEA filamin binding GO:0031005 IEA G-protein beta-subunit binding GO:0031681 IBA morphine receptor activity GO:0038047 IBA morphine receptor activity GO:0038047 ISS neuropeptide binding GO:0042923 IBA,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Estrogen signaling pathway - Homo sapiens (human) hsa04915 Morphine addiction - Homo sapiens (human) hsa05032,CHEMBL CHEMBL333357,P35372,Mu opioid receptor,1.0,PRIMARY,YES,N[C@@H](Cc1ccc(O)cc1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](Cc4ccccc4)C(=O)N,3,48,"InChI=1S/C32H37N5O5/c33-25(18-23-13-15-24(38)16-14-23)32(42)37-17-7-12-28(37)31(41)36-27(20-22-10-5-2-6-11-22)30(40)35-26(29(34)39)19-21-8-3-1-4-9-21/h1-6,8-11,13-16,25-28,38H,7,12,17-20,33H2,(H2,34,39)(H,35,40)(H,36,41)/t25-,26-,27-,28-/m0/s1",XIJHWXXXIMEHKW-LJWNLINESA-N,"c(""Unchecked"", ""Mu opioid receptor"", ""Delta opioid receptor"", ""Regulator of G-protein signaling 4"", ""Kappa opioid receptor"")",4988,OPRM,R-HSA-111885 Opioid Signalling R-HSA-162582 Signal Transduction R-HSA-202040 G-protein activation R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,9242668 TAS GO:0005783 endoplasmic reticulum 9242668 TAS GO:0005794 Golgi apparatus TAS GO:0005886 plasma membrane 7905839 TAS GO:0005887 integral component of plasma membrane IEA GO:0005925 focal adhesion IEA GO:0032590 dendrite membrane IEA GO:0032839 dendrite cytoplasm IEA GO:0042383 sarcolemma IBA GO:0043005 neuron projection IEA GO:0043204 perikaryon IEA GO:0045121 membrane raft IEA GO:0098794 postsynapse,"acute inflammatory response to antigenic stimulus GO:0002438 IEA G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 7905839 TAS adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 IEA negative regulation of adenylate cyclase activity GO:0007194 ISS phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 ISS neuropeptide signaling pathway GO:0007218 IEA chemical synaptic transmission GO:0007268 IBA sensory perception GO:0007600 9689128 NAS locomotory behavior GO:0007626 IEA negative regulation of cell proliferation GO:0008285 2159143 TAS response to radiation GO:0009314 IEA sensory perception of pain GO:0019233 IBA sensory perception of pain GO:0019233 ISS adenylate cyclase-inhibiting opioid receptor signaling pathway GO:0031635 IEA response to food GO:0032094 IEA positive regulation of appetite GO:0032100 IEA response to lipopolysaccharide GO:0032496 IEA cellular response to stress GO:0033554 21039637 IMP wound healing GO:0042060 IEA response to cocaine GO:0042220 IEA eating behavior GO:0042755 IEA estrous cycle GO:0044849 IEA behavioral response to ethanol GO:0048149 21039637 IMP positive regulation of neurogenesis GO:0050769 ISS regulation of sensory perception of pain GO:0051930 IEA excitatory postsynaptic potential GO:0060079 IEA negative regulation of Wnt protein secretion GO:0061358 20214800 IMP positive regulation of ERK1 and ERK2 cascade GO:0070374 ISS calcium ion transmembrane transport GO:0070588 IEA response to growth factor GO:0070848 IEA cellular response to morphine GO:0071315 IBA regulation of N-methyl-D-aspartate selective glutamate receptor activity GO:2000310 ISS",G-protein alpha-subunit binding 20214800 GO:0001965 IDA G-protein coupled receptor activity GO:0004930 ISS beta-endorphin receptor activity 9689128 GO:0004979 IMP voltage-gated calcium channel activity GO:0005245 ISS protein binding 14573758 19788913 20214800 23597562 23840749 GO:0005515 IPI protein C-terminus binding GO:0008022 IEA protein domain specific binding GO:0019904 IEA filamin binding GO:0031005 IEA G-protein beta-subunit binding GO:0031681 IBA morphine receptor activity GO:0038047 IBA morphine receptor activity GO:0038047 ISS neuropeptide binding GO:0042923 IBA,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Estrogen signaling pathway - Homo sapiens (human) hsa04915 Morphine addiction - Homo sapiens (human) hsa05032,CHEMBL CHEMBL2377385,P11229,Muscarinic acetylcholine receptor M1,1.0,PRIMARY,NO,[Br-].CC[N+](C)(CC)CCOC(=O)C(c1ccccc1)c2ccccc2,3,8,"InChI=1S/C21H28NO2.BrH/c1-4-22(3,5-2)16-17-24-21(23)20(18-12-8-6-9-13-18)19-14-10-7-11-15-19;/h6-15,20H,4-5,16-17H2,1-3H3;1H/q+1;/p-1",WMUOPJLADBOCIX-UHFFFAOYSA-M,"c(""Unchecked"", ""Muscarinic acetylcholine receptor M4"", ""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M1"")",1128,ACM1,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Amine ligand-binding receptors R-HSA-375280 GPCR downstream signaling R-HSA-388396 Muscarinic acetylcholine receptors R-HSA-390648 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 IEA postsynaptic density GO:0014069 IEA membrane GO:0016020 7925360 TAS cell junction GO:0030054 IEA dendrite GO:0030425 IEA asymmetric synapse GO:0032279 IEA axon terminus GO:0043679 IEA synapse GO:0045202 IBA postsynaptic membrane GO:0045211 IEA,"regulation of vascular smooth muscle contraction GO:0003056 IBA cellular protein modification process 1411529 GO:0006464 TAS signal transduction 3443095 9614217 GO:0007165 TAS G-protein coupled receptor signaling pathway 7925360 GO:0007186 TAS adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway GO:0007197 IBA protein kinase C-activating G-protein coupled receptor signaling pathway 9603968 GO:0007205 TAS phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway 8139539 GO:0007207 TAS G-protein coupled acetylcholine receptor signaling pathway 8139539 GO:0007213 TAS synaptic transmission, cholinergic GO:0007271 IBA neuromuscular synaptic transmission GO:0007274 IEA nervous system development 2739737 GO:0007399 TAS cell proliferation 1905013 GO:0008283 TAS positive regulation of cell proliferation 2739737 GO:0008284 TAS regulation of locomotion GO:0040012 IEA positive regulation of ion transport 14657398 GO:0043270 IGI saliva secretion GO:0046541 IEA cognition GO:0050890 IEA positive regulation of intracellular protein transport GO:0090316 IEA",9614217 GO:0004435 phosphatidylinositol phospholipase C activity TAS GO:0008144 drug binding IEA GO:0016907 G-protein coupled acetylcholine receptor activity IEA,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human),CHEMBL CHEMBL3616501,P11229,Muscarinic acetylcholine receptor M1,1.0,PRIMARY,YES,CN(Cc1ccc(F)cc1)\C(=N\c2ccc3C[C@@H](O)[C@H](NC(=O)c4ccc(cc4)c5ccccc5)c3c2)\C,3,6,"InChI=1S/C32H30FN3O2/c1-21(36(2)20-22-8-15-27(33)16-9-22)34-28-17-14-26-18-30(37)31(29(26)19-28)35-32(38)25-12-10-24(11-13-25)23-6-4-3-5-7-23/h3-17,19,30-31,37H,18,20H2,1-2H3,(H,35,38)/b34-21+/t30-,31-/m1/s1",KOQVBYSCBCRVQJ-SVUXJTORSA-N,"c(""Muscarinic acetylcholine receptor M1"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M4"")",1128,ACM1,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Amine ligand-binding receptors R-HSA-375280 GPCR downstream signaling R-HSA-388396 Muscarinic acetylcholine receptors R-HSA-390648 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 IEA postsynaptic density GO:0014069 IEA membrane GO:0016020 7925360 TAS cell junction GO:0030054 IEA dendrite GO:0030425 IEA asymmetric synapse GO:0032279 IEA axon terminus GO:0043679 IEA synapse GO:0045202 IBA postsynaptic membrane GO:0045211 IEA,"regulation of vascular smooth muscle contraction GO:0003056 IBA cellular protein modification process 1411529 GO:0006464 TAS signal transduction 3443095 9614217 GO:0007165 TAS G-protein coupled receptor signaling pathway 7925360 GO:0007186 TAS adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway GO:0007197 IBA protein kinase C-activating G-protein coupled receptor signaling pathway 9603968 GO:0007205 TAS phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway 8139539 GO:0007207 TAS G-protein coupled acetylcholine receptor signaling pathway 8139539 GO:0007213 TAS synaptic transmission, cholinergic GO:0007271 IBA neuromuscular synaptic transmission GO:0007274 IEA nervous system development 2739737 GO:0007399 TAS cell proliferation 1905013 GO:0008283 TAS positive regulation of cell proliferation 2739737 GO:0008284 TAS regulation of locomotion GO:0040012 IEA positive regulation of ion transport 14657398 GO:0043270 IGI saliva secretion GO:0046541 IEA cognition GO:0050890 IEA positive regulation of intracellular protein transport GO:0090316 IEA",9614217 GO:0004435 phosphatidylinositol phospholipase C activity TAS GO:0008144 drug binding IEA GO:0016907 G-protein coupled acetylcholine receptor activity IEA,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human),CHEMBL CHEMBL212141,P20309,Muscarinic acetylcholine receptor M3,1.0,PRIMARY,NO,CC(C)NC(=O)[C@H]1CCCN1C(=O)[C@@H]2C[C@@H](O)CN2C(=O)CC(c3ccc(F)cc3)(c4ccc(F)cc4)c5ccc(F)cc5,5,9,"InChI=1S/C34H36F3N3O4/c1-21(2)38-32(43)29-4-3-17-39(29)33(44)30-18-28(41)20-40(30)31(42)19-34(22-5-11-25(35)12-6-22,23-7-13-26(36)14-8-23)24-9-15-27(37)16-10-24/h5-16,21,28-30,41H,3-4,17-20H2,1-2H3,(H,38,43)/t28-,29-,30+/m1/s1",XNEGPONSGSBZSW-OCBJUFRSSA-N,"c(""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M1"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M4"", ""Muscarinic acetylcholine receptor M5"", ""Muscarinic acetylcholine receptor M1 and M3"", ""Muscarinic acetylcholine receptors; M2 & M3"", ""Unchecked"")",1131,ACM3,Metabolism R-HSA-1430728 Signal Transduction R-HSA-162582 Integration of energy metabolism R-HSA-163685 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Amine ligand-binding receptors R-HSA-375280 GPCR downstream signaling R-HSA-388396 Muscarinic acetylcholine receptors R-HSA-390648 Acetylcholine regulates insulin secretion R-HSA-399997 G alpha (q) signalling events R-HSA-416476 Regulation of insulin secretion R-HSA-422356 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 ISS basolateral plasma membrane GO:0016323 IEA cell junction GO:0030054 IEA dendrite GO:0030425 IEA asymmetric synapse GO:0032279 IEA axon terminus GO:0043679 IEA synapse GO:0045202 IBA postsynaptic membrane GO:0045211 IEA,"GO:0003056 regulation of vascular smooth muscle contraction IBA 10051746 GO:0006464 cellular protein modification process TAS GO:0006939 smooth muscle contraction IEA 10940357 GO:0007165 signal transduction TAS 9603968 GO:0007186 G-protein coupled receptor signaling pathway TAS GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway IBA GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway IBA GO:0007213 G-protein coupled acetylcholine receptor signaling pathway ISS GO:0007271 synaptic transmission, cholinergic IBA 2739737 GO:0007399 nervous system development TAS 8063729 GO:0008283 cell proliferation TAS GO:0045987 positive regulation of smooth muscle contraction IEA GO:0046541 saliva secretion IEA",phosphatidylinositol phospholipase C activity TAS 1905013 GO:0004435 receptor activity TAS 10940357 GO:0004872 protein binding IPI 19575010 GO:0005515 drug binding IEA GO:0008144 G-protein coupled acetylcholine receptor activity ISS GO:0016907 acetylcholine binding ISS GO:0042166,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04911 Insulin secretion - Homo sapiens (human) hsa04970 Salivary secretion - Homo sapiens (human) hsa04971 Gastric acid secretion - Homo sapiens (human) hsa04972 Pancreatic secretion - Homo sapiens (human),CHEMBL CHEMBL402207,P08173,Muscarinic acetylcholine receptor M4,1.0,ORTHOGONAL,NO,[I-].[I-].C[N+]1(CCCC(O)(c2ccccc2)c3ccccc3)CCC(CC1)C4CC[N+](C)(CCCC(O)(c5ccccc5)c6ccccc6)CC4,5,8,"InChI=1S/C44H58N2O2.2HI/c1-45(31-15-29-43(47,39-17-7-3-8-18-39)40-19-9-4-10-20-40)33-25-37(26-34-45)38-27-35-46(2,36-28-38)32-16-30-44(48,41-21-11-5-12-22-41)42-23-13-6-14-24-42;;/h3-14,17-24,37-38,47-48H,15-16,25-36H2,1-2H3;2*1H/q+2;;/p-2",DYKWWNCEKVABFK-UHFFFAOYSA-L,"c(""Muscarinic acetylcholine receptor M4"", ""Muscarinic acetylcholine receptor M5"", ""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M1"")",1132,ACM4,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375280 Amine ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-390648 Muscarinic acetylcholine receptors R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,GO:0005737 cytoplasm IEA GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane IEA GO:0014069 postsynaptic density IEA GO:0030054 cell junction IEA GO:0032279 asymmetric synapse IEA GO:0042383 sarcolemma IEA GO:0043025 neuronal cell body IEA GO:0043679 axon terminus IEA GO:0045202 synapse IBA GO:0045211 postsynaptic membrane IEA,"signal transduction TAS 9603968 GO:0007165 cell surface receptor signaling pathway TAS 2739737 GO:0007166 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway IBA GO:0007197 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway IBA GO:0007207 G-protein coupled acetylcholine receptor signaling pathway TAS 3443095 GO:0007213 synaptic transmission, cholinergic IBA GO:0007271 cell proliferation TAS 2739737 GO:0008283 regulation of locomotion IEA GO:0040012 positive regulation of GTPase activity IEA GO:0043547",GO:0005085 guanyl-nucleotide exchange factor activity IEA GO:0016907 G-protein coupled acetylcholine receptor activity IEA,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Cholinergic synapse - Homo sapiens (human) hsa04725 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04810,CHEMBL CHEMBL59898,P08173,Muscarinic acetylcholine receptor M4,1.0,PRIMARY,NO,CCOC(=O)c1c(C)[nH]c2ccc3OC4N(CCc5cc(OC)ccc45)Cc3c12,5,22,"InChI=1S/C23H24N2O4/c1-4-28-23(26)20-13(2)24-18-7-8-19-17(21(18)20)12-25-10-9-14-11-15(27-3)5-6-16(14)22(25)29-19/h5-8,11,22,24H,4,9-10,12H2,1-3H3",VDDUJINYXKGZLV-UHFFFAOYSA-N,"c(""Muscarinic acetylcholine receptor M1"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M4"", ""Muscarinic acetylcholine receptor M5"", ""Unchecked"")",1132,ACM4,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375280 Amine ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-390648 Muscarinic acetylcholine receptors R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,GO:0005737 cytoplasm IEA GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane IEA GO:0014069 postsynaptic density IEA GO:0030054 cell junction IEA GO:0032279 asymmetric synapse IEA GO:0042383 sarcolemma IEA GO:0043025 neuronal cell body IEA GO:0043679 axon terminus IEA GO:0045202 synapse IBA GO:0045211 postsynaptic membrane IEA,"signal transduction TAS 9603968 GO:0007165 cell surface receptor signaling pathway TAS 2739737 GO:0007166 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway IBA GO:0007197 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway IBA GO:0007207 G-protein coupled acetylcholine receptor signaling pathway TAS 3443095 GO:0007213 synaptic transmission, cholinergic IBA GO:0007271 cell proliferation TAS 2739737 GO:0008283 regulation of locomotion IEA GO:0040012 positive regulation of GTPase activity IEA GO:0043547",GO:0005085 guanyl-nucleotide exchange factor activity IEA GO:0016907 G-protein coupled acetylcholine receptor activity IEA,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Cholinergic synapse - Homo sapiens (human) hsa04725 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04810,CHEMBL CHEMBL22870,P25103,Neurokinin 1 receptor,1.0,ORTHOGONAL,NO,CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)OCc3cc(cc(c3)C(F)(F)F)C(F)(F)F,3,61,"InChI=1S/C22H18F6N2O3/c1-12(31)30-19(8-14-10-29-18-5-3-2-4-17(14)18)20(32)33-11-13-6-15(21(23,24)25)9-16(7-13)22(26,27)28/h2-7,9-10,19,29H,8,11H2,1H3,(H,30,31)/t19-/m0/s1",BYYQYXVAWXAYQC-IBGZPJMESA-N,"c(""Neurokinin 1 receptor"", ""Neurokinin 2 receptor"", ""Neurokinin 3 receptor"", ""Unchecked"", ""Prelamin-A/C"", ""Nuclear factor NF-kappa-B p105 subunit"", ""Lysine-specific demethylase 4D-like"", ""Microtubule-associated protein tau"", ""Aldehyde dehydrogenase 1A1"", ""Menin/Histone-lysine N-methyltransferase MLL"", ""DNA-(apurinic or apyrimidinic site) lyase"", ""Bloom syndrome protein"", ""Thrombopoietin"", ""Cellular tumor antigen p53"", ""Neuropeptide S receptor"", ""DNA polymerase beta"", ""Lysine-specific demethylase 4A"", ""M-phase phosphoprotein 8"", ""Histone-lysine N-methyltransferase, H3 lysine-9 specific 3"", ""Chromobox protein homolog 1"", ""DNA polymerase iota"", ""DNA polymerase kappa"", ""Mothers against decapentaplegic homolog 3"", ""Ubiquitin carboxyl-terminal hydrolase 1"", ""Glucagon-like peptide 1 receptor"", ""Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1"", ""TAR DNA-binding protein 43"", ""Rap guanine nucleotide exchange factor 4"", ""Parathyroid hormone receptor"", ""Cerebroside-sulfatase"")",6869,NK1R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 Tachykinin receptors bind tachykinins R-HSA-380095 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,cytosol IEA GO:0005829 plasma membrane IDA 17986524 GO:0005886 plasma membrane TAS GO:0005886 integral component of plasma membrane TAS 1657150 GO:0005887 cell surface IEA GO:0009986 dendrite IEA GO:0030425 cell body IEA GO:0044297,"GO:0002118 aggressive behavior IEA GO:0002526 acute inflammatory response IEA GO:0002687 positive regulation of leukocyte migration IEA GO:0003051 angiotensin-mediated drinking behavior IEA GO:0006954 inflammatory response 10854844 TAS GO:0007166 cell surface receptor signaling pathway IBA GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway 1657150 TAS GO:0007204 positive regulation of cytosolic calcium ion concentration IEA GO:0007217 tachykinin receptor signaling pathway 17986524 IDA GO:0007268 chemical synaptic transmission IBA GO:0007616 long-term memory IEA GO:0008306 associative learning IEA GO:0009408 response to heat IEA GO:0009582 detection of abiotic stimulus 9537323 TAS GO:0010193 response to ozone IEA GO:0010634 positive regulation of epithelial cell migration IEA GO:0010996 response to auditory stimulus IEA GO:0014910 regulation of smooth muscle cell migration IEA GO:0019233 sensory perception of pain IEA GO:0032224 positive regulation of synaptic transmission, cholinergic IEA GO:0032230 positive regulation of synaptic transmission, GABAergic IEA GO:0032355 response to estradiol IEA GO:0032570 response to progesterone IEA GO:0035094 response to nicotine IEA GO:0035106 operant conditioning IEA GO:0035815 positive regulation of renal sodium excretion IEA GO:0042713 sperm ejaculation IEA GO:0042755 eating behavior IEA GO:0043117 positive regulation of vascular permeability IEA GO:0043278 response to morphine IEA GO:0045471 response to ethanol IEA GO:0045760 positive regulation of action potential IEA GO:0045777 positive regulation of blood pressure IEA GO:0045778 positive regulation of ossification IEA GO:0045907 positive regulation of vasoconstriction IEA GO:0045987 positive regulation of smooth muscle contraction IBA GO:0046878 positive regulation of saliva secretion IEA GO:0046887 positive regulation of hormone secretion IEA GO:0048266 behavioral response to pain IEA GO:0048660 regulation of smooth muscle cell proliferation IEA GO:0050671 positive regulation of lymphocyte proliferation IEA GO:0050679 positive regulation of epithelial cell proliferation IEA GO:0051496 positive regulation of stress fiber assembly IEA GO:0051602 response to electrical stimulus IEA GO:0060083 smooth muscle contraction involved in micturition IEA GO:0070474 positive regulation of uterine smooth muscle contraction IEA",tachykinin receptor activity GO:0004995 TAS 8985172 protein binding GO:0005515 IPI 17986524 23597562 substance P receptor activity GO:0016496 IBA,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa05162 Measles - Homo sapiens (human),CHEMBL CHEMBL27006,P25103,Neurokinin 1 receptor,1.0,PRIMARY,NO,FC(F)(F)c1cc(CO[C@H]2CCCN[C@H]2c3ccccc3)cc(c1)C(F)(F)F,4,29,"InChI=1S/C20H19F6NO/c21-19(22,23)15-9-13(10-16(11-15)20(24,25)26)12-28-17-7-4-8-27-18(17)14-5-2-1-3-6-14/h1-3,5-6,9-11,17-18,27H,4,7-8,12H2/t17-,18-/m0/s1",FCDRFVCGMLUYPG-ROUUACIJSA-N,"c(""Neurokinin 1 receptor"", ""Unchecked"", ""Neurokinin 2 receptor"", ""Neurokinin 3 receptor"", ""Menin/Histone-lysine N-methyltransferase MLL"", ""Thyroid stimulating hormone receptor"", ""Microtubule-associated protein tau"", ""Cellular tumor antigen p53"", ""Beta-glucocerebrosidase"", ""Arachidonate 15-lipoxygenase, type II"", ""Ubiquitin carboxyl-terminal hydrolase 1"", ""DNA-(apurinic or apyrimidinic site) lyase"")",6869,NK1R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 Tachykinin receptors bind tachykinins R-HSA-380095 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,cytosol IEA GO:0005829 plasma membrane IDA 17986524 GO:0005886 plasma membrane TAS GO:0005886 integral component of plasma membrane TAS 1657150 GO:0005887 cell surface IEA GO:0009986 dendrite IEA GO:0030425 cell body IEA GO:0044297,"GO:0002118 aggressive behavior IEA GO:0002526 acute inflammatory response IEA GO:0002687 positive regulation of leukocyte migration IEA GO:0003051 angiotensin-mediated drinking behavior IEA GO:0006954 inflammatory response 10854844 TAS GO:0007166 cell surface receptor signaling pathway IBA GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway 1657150 TAS GO:0007204 positive regulation of cytosolic calcium ion concentration IEA GO:0007217 tachykinin receptor signaling pathway 17986524 IDA GO:0007268 chemical synaptic transmission IBA GO:0007616 long-term memory IEA GO:0008306 associative learning IEA GO:0009408 response to heat IEA GO:0009582 detection of abiotic stimulus 9537323 TAS GO:0010193 response to ozone IEA GO:0010634 positive regulation of epithelial cell migration IEA GO:0010996 response to auditory stimulus IEA GO:0014910 regulation of smooth muscle cell migration IEA GO:0019233 sensory perception of pain IEA GO:0032224 positive regulation of synaptic transmission, cholinergic IEA GO:0032230 positive regulation of synaptic transmission, GABAergic IEA GO:0032355 response to estradiol IEA GO:0032570 response to progesterone IEA GO:0035094 response to nicotine IEA GO:0035106 operant conditioning IEA GO:0035815 positive regulation of renal sodium excretion IEA GO:0042713 sperm ejaculation IEA GO:0042755 eating behavior IEA GO:0043117 positive regulation of vascular permeability IEA GO:0043278 response to morphine IEA GO:0045471 response to ethanol IEA GO:0045760 positive regulation of action potential IEA GO:0045777 positive regulation of blood pressure IEA GO:0045778 positive regulation of ossification IEA GO:0045907 positive regulation of vasoconstriction IEA GO:0045987 positive regulation of smooth muscle contraction IBA GO:0046878 positive regulation of saliva secretion IEA GO:0046887 positive regulation of hormone secretion IEA GO:0048266 behavioral response to pain IEA GO:0048660 regulation of smooth muscle cell proliferation IEA GO:0050671 positive regulation of lymphocyte proliferation IEA GO:0050679 positive regulation of epithelial cell proliferation IEA GO:0051496 positive regulation of stress fiber assembly IEA GO:0051602 response to electrical stimulus IEA GO:0060083 smooth muscle contraction involved in micturition IEA GO:0070474 positive regulation of uterine smooth muscle contraction IEA",tachykinin receptor activity GO:0004995 TAS 8985172 protein binding GO:0005515 IPI 17986524 23597562 substance P receptor activity GO:0016496 IBA,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa05162 Measles - Homo sapiens (human),CHEMBL CHEMBL235363,P25103,Neurokinin 1 receptor,1.0,PRIMARY,YES,CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H]3CCCN3C(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@@H](N)CCCN=C(N)N)C(=O)N,3,25,"InChI=1S/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1",ADNPLDHMAVUMIW-CUZNLEPHSA-N,"c(""Neurokinin 1 receptor"", ""Unchecked"", ""Neurokinin 2 receptor"", ""Neurokinin 3 receptor"", ""DNA polymerase kappa"")",6869,NK1R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 Tachykinin receptors bind tachykinins R-HSA-380095 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,cytosol IEA GO:0005829 plasma membrane IDA 17986524 GO:0005886 plasma membrane TAS GO:0005886 integral component of plasma membrane TAS 1657150 GO:0005887 cell surface IEA GO:0009986 dendrite IEA GO:0030425 cell body IEA GO:0044297,"GO:0002118 aggressive behavior IEA GO:0002526 acute inflammatory response IEA GO:0002687 positive regulation of leukocyte migration IEA GO:0003051 angiotensin-mediated drinking behavior IEA GO:0006954 inflammatory response 10854844 TAS GO:0007166 cell surface receptor signaling pathway IBA GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway 1657150 TAS GO:0007204 positive regulation of cytosolic calcium ion concentration IEA GO:0007217 tachykinin receptor signaling pathway 17986524 IDA GO:0007268 chemical synaptic transmission IBA GO:0007616 long-term memory IEA GO:0008306 associative learning IEA GO:0009408 response to heat IEA GO:0009582 detection of abiotic stimulus 9537323 TAS GO:0010193 response to ozone IEA GO:0010634 positive regulation of epithelial cell migration IEA GO:0010996 response to auditory stimulus IEA GO:0014910 regulation of smooth muscle cell migration IEA GO:0019233 sensory perception of pain IEA GO:0032224 positive regulation of synaptic transmission, cholinergic IEA GO:0032230 positive regulation of synaptic transmission, GABAergic IEA GO:0032355 response to estradiol IEA GO:0032570 response to progesterone IEA GO:0035094 response to nicotine IEA GO:0035106 operant conditioning IEA GO:0035815 positive regulation of renal sodium excretion IEA GO:0042713 sperm ejaculation IEA GO:0042755 eating behavior IEA GO:0043117 positive regulation of vascular permeability IEA GO:0043278 response to morphine IEA GO:0045471 response to ethanol IEA GO:0045760 positive regulation of action potential IEA GO:0045777 positive regulation of blood pressure IEA GO:0045778 positive regulation of ossification IEA GO:0045907 positive regulation of vasoconstriction IEA GO:0045987 positive regulation of smooth muscle contraction IBA GO:0046878 positive regulation of saliva secretion IEA GO:0046887 positive regulation of hormone secretion IEA GO:0048266 behavioral response to pain IEA GO:0048660 regulation of smooth muscle cell proliferation IEA GO:0050671 positive regulation of lymphocyte proliferation IEA GO:0050679 positive regulation of epithelial cell proliferation IEA GO:0051496 positive regulation of stress fiber assembly IEA GO:0051602 response to electrical stimulus IEA GO:0060083 smooth muscle contraction involved in micturition IEA GO:0070474 positive regulation of uterine smooth muscle contraction IEA",tachykinin receptor activity GO:0004995 TAS 8985172 protein binding GO:0005515 IPI 17986524 23597562 substance P receptor activity GO:0016496 IBA,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa05162 Measles - Homo sapiens (human),CHEMBL CHEMBL308148,P21452,Neurokinin 2 receptor,1.0,ORTHOGONAL,NO,CN(C[C@@H](CCN1CCC(CC1)(NC(=O)C)c2ccccc2)c3ccc(Cl)c(Cl)c3)C(=O)c4ccccc4,2,7,"InChI=1S/C31H35Cl2N3O2/c1-23(37)34-31(27-11-7-4-8-12-27)16-19-36(20-17-31)18-15-26(25-13-14-28(32)29(33)21-25)22-35(2)30(38)24-9-5-3-6-10-24/h3-14,21,26H,15-20,22H2,1-2H3,(H,34,37)/t26-/m1/s1",PGKXDIMONUAMFR-AREMUKBSSA-N,"c(""Neurokinin 2 receptor"", ""Neurokinin 1 receptor"")",6865,NK2R,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-380095 Tachykinin receptors bind tachykinins R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 2173708 TAS,"muscle contraction GO:0006936 TAS 2173708 cell surface receptor signaling pathway GO:0007166 IBA tachykinin receptor signaling pathway GO:0007217 IEA chemical synaptic transmission GO:0007268 IBA excretion GO:0007588 TAS 10862829 positive regulation of acetylcholine secretion, neurotransmission GO:0014057 IEA intestine smooth muscle contraction GO:0014827 IEA negative regulation of luteinizing hormone secretion GO:0033685 IEA operant conditioning GO:0035106 IEA positive regulation of vascular permeability GO:0043117 IEA positive regulation of smooth muscle contraction GO:0045987 IBA response to electrical stimulus GO:0051602 IEA prolactin secretion GO:0070459 IEA positive regulation of uterine smooth muscle contraction GO:0070474 IEA",8307161 TAS GO:0004995 tachykinin receptor activity 23597562 IPI GO:0005515 protein binding IBA GO:0016497 substance K receptor activity,Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL217406,P21452,Neurokinin 2 receptor,1.0,PRIMARY,NO,CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc2c[nH]cn2)[C@@H](C)O)C(C)C)C(=O)N,3,22,"InChI=1S/C50H80N14O14S/c1-26(2)18-34(45(73)58-32(42(53)70)15-17-79-6)57-38(67)23-55-49(77)40(27(3)4)63-47(75)35(19-29-12-8-7-9-13-29)60-48(76)37(24-65)62-46(74)36(21-39(68)69)61-50(78)41(28(5)66)64-44(72)33(14-10-11-16-51)59-43(71)31(52)20-30-22-54-25-56-30/h7-9,12-13,22,25-28,31-37,40-41,65-66H,10-11,14-21,23-24,51-52H2,1-6H3,(H2,53,70)(H,54,56)(H,55,77)(H,57,67)(H,58,73)(H,59,71)(H,60,76)(H,61,78)(H,62,74)(H,63,75)(H,64,72)(H,68,69)/t28-,31+,32+,33+,34+,35+,36+,37+,40+,41+/m1/s1",HEAUFJZALFKPBA-JPQUDPSNSA-N,"c(""Neurokinin 1 receptor"", ""Neurokinin 2 receptor"", ""Neurokinin 3 receptor"")",6865,NK2R,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-380095 Tachykinin receptors bind tachykinins R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 2173708 TAS,"muscle contraction GO:0006936 TAS 2173708 cell surface receptor signaling pathway GO:0007166 IBA tachykinin receptor signaling pathway GO:0007217 IEA chemical synaptic transmission GO:0007268 IBA excretion GO:0007588 TAS 10862829 positive regulation of acetylcholine secretion, neurotransmission GO:0014057 IEA intestine smooth muscle contraction GO:0014827 IEA negative regulation of luteinizing hormone secretion GO:0033685 IEA operant conditioning GO:0035106 IEA positive regulation of vascular permeability GO:0043117 IEA positive regulation of smooth muscle contraction GO:0045987 IBA response to electrical stimulus GO:0051602 IEA prolactin secretion GO:0070459 IEA positive regulation of uterine smooth muscle contraction GO:0070474 IEA",8307161 TAS GO:0004995 tachykinin receptor activity 23597562 IPI GO:0005515 protein binding IBA GO:0016497 substance K receptor activity,Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL3422010,P29371,Neurokinin 3 receptor,1.0,ORTHOGONAL,NO,C[C@H]1N(CCn2c1nnc2c3csc(C)n3)C(=O)c4ccc(cc4)c5cccs5,6,10,"InChI=1S/C21H19N5OS2/c1-13-19-23-24-20(17-12-29-14(2)22-17)26(19)10-9-25(13)21(27)16-7-5-15(6-8-16)18-4-3-11-28-18/h3-8,11-13H,9-10H2,1-2H3/t13-/m1/s1",BWTVMVHFJRFVFO-CYBMUJFWSA-N,"c(""Neurokinin 3 receptor"", ""Neurokinin 1 receptor"", ""Neurokinin 2 receptor"", ""Kappa opioid receptor"", ""Gonadotropin-releasing hormone receptor"", ""Neuropeptide FF receptor 1"", ""Unchecked"")",6870,NK3R,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-380095 Tachykinin receptors bind tachykinins R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,nucleus GO:0005634 IEA cytoplasm GO:0005737 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 TAS 1374246 dendrite membrane GO:0032590 IEA neuronal cell body membrane GO:0032809 IEA,IEA GO:0007217 tachykinin receptor signaling pathway IEA GO:0007568 aging IEA GO:0010460 positive regulation of heart rate IEA GO:0032355 response to estradiol IEA GO:0042053 regulation of dopamine metabolic process IEA GO:0042220 response to cocaine IEA GO:0042538 hyperosmotic salinity response IEA GO:0043278 response to morphine IEA GO:0045777 positive regulation of blood pressure IEA GO:0060259 regulation of feeding behavior IEA GO:0070474 positive regulation of uterine smooth muscle contraction,tachykinin receptor activity GO:0004995 IEA protein binding GO:0005515 23597562 IPI,Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL10188,P29371,Neurokinin 3 receptor,1.0,PRIMARY,NO,CC[C@H](NC(=O)c1c(O)c(nc2ccccc12)c3ccccc3)c4ccccc4,11,53,"InChI=1S/C25H22N2O2/c1-2-20(17-11-5-3-6-12-17)27-25(29)22-19-15-9-10-16-21(19)26-23(24(22)28)18-13-7-4-8-14-18/h3-16,20,28H,2H2,1H3,(H,27,29)/t20-/m0/s1",BIAVGWDGIJKWRM-FQEVSTJZSA-N,"c(""Neurokinin 3 receptor"", ""Neurokinin 2 receptor"", ""Neurokinin 1 receptor"", ""Unchecked"", ""Mu opioid receptor"", ""Pregnane X receptor"", ""Kappa opioid receptor"", ""Adenosine A1 receptor"", ""Adenosine A3 receptor"", ""Translocator protein"", ""Cholecystokinin B receptor"", ""Prostanoid EP4 receptor"")",6870,NK3R,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-380095 Tachykinin receptors bind tachykinins R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,nucleus GO:0005634 IEA cytoplasm GO:0005737 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 TAS 1374246 dendrite membrane GO:0032590 IEA neuronal cell body membrane GO:0032809 IEA,IEA GO:0007217 tachykinin receptor signaling pathway IEA GO:0007568 aging IEA GO:0010460 positive regulation of heart rate IEA GO:0032355 response to estradiol IEA GO:0042053 regulation of dopamine metabolic process IEA GO:0042220 response to cocaine IEA GO:0042538 hyperosmotic salinity response IEA GO:0043278 response to morphine IEA GO:0045777 positive regulation of blood pressure IEA GO:0060259 regulation of feeding behavior IEA GO:0070474 positive regulation of uterine smooth muscle contraction,tachykinin receptor activity GO:0004995 IEA protein binding GO:0005515 23597562 IPI,Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL59986,P43681,Neuronal acetylcholine receptor protein alpha-4 subunit,1.0,PRIMARY,YES,C(Oc1cccnc1)[C@@H]2CCN2,2,43,"InChI=1S/C9H12N2O/c1-2-9(6-10-4-1)12-7-8-3-5-11-8/h1-2,4,6,8,11H,3,5,7H2/t8-/m0/s1",XKFMBGWHHBCWCD-QMMMGPOBSA-N,"c(""Neuronal acetylcholine receptor; alpha4/beta2"", ""Neuronal acetylcholine receptor protein alpha-7 subunit"", ""Neuronal acetylcholine receptor; alpha3/beta4"", ""Unchecked"", ""K177cell line"", ""IMR-32"", ""Neuronal acetylcholine receptor subunit alpha-3"", ""Neuronal acetylcholine receptor protein alpha-4 subunit"", ""Acetylcholine receptor; alpha1/beta1/delta/gamma"")",1137,ACHA4,Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-112314 Transmission across Chemical Synapses R-HSA-112315 Neuronal System R-HSA-112316 Acetylcholine Binding And Downstream Events R-HSA-181431 Presynaptic nicotinic acetylcholine receptors R-HSA-622323 Postsynaptic nicotinic acetylcholine receptors R-HSA-622327 Highly sodium permeable acetylcholine nicotinic receptors R-HSA-629587 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors R-HSA-629594 Highly calcium permeable nicotinic acetylcholine receptors R-HSA-629597 Activation of Nicotinic Acetylcholine Receptors R-HSA-629602,ISS GO:0005886 plasma membrane TAS GO:0005886 plasma membrane IDA 8906617 acetylcholine-gated channel complex GO:0005892 ISS GO:0009897 external side of plasma membrane ISS GO:0016020 membrane NAS 8906617 integral component of membrane GO:0016021 IEA GO:0030054 cell junction ISS GO:0030425 dendrite ISS GO:0043025 neuronal cell body IEA GO:0045211 postsynaptic membrane,"action potential GO:0001508 ISS response to hypoxia GO:0001666 12189247 IDA DNA repair GO:0006281 16332175 IMP ion transport GO:0006811 8906617 NAS calcium ion transport GO:0006816 ISS response to oxidative stress GO:0006979 16332175 IMP signal transduction GO:0007165 8906617 IDA chemical synaptic transmission GO:0007268 7550350 NAS synaptic transmission, cholinergic GO:0007271 IBA synaptic transmission, cholinergic GO:0007271 ISS neuromuscular synaptic transmission GO:0007274 IBA respiratory gaseous exchange GO:0007585 IEA locomotory behavior GO:0007626 IEA regulation of dopamine secretion GO:0014059 ISS sensory perception of pain GO:0019233 ISS response to nicotine GO:0035094 12189247 IDA behavioral response to nicotine GO:0035095 17955458 IMP exploration behavior GO:0035640 IEA B cell activation GO:0042113 ISS regulation of membrane potential GO:0042391 ISS neurological system process GO:0050877 7550350 17613539 IMP cognition GO:0050890 14623738 IMP membrane depolarization GO:0051899 ISS inhibitory postsynaptic potential GO:0060080 ISS cation transmembrane transport GO:0098655 IEA",acetylcholine-activated cation-selective channel activity 8906617 GO:0004889 IDA acetylcholine-activated cation-selective channel activity 20438829 GO:0004889 TAS ligand-gated ion channel activity 20438829 GO:0015276 TAS acetylcholine receptor activity 8906617 GO:0015464 IDA acetylcholine binding contributes_to GO:0042166 IBA acetylcholine binding 8906617 GO:0042166 IC,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human) hsa05033 Nicotine addiction - Homo sapiens (human),CHEMBL CHEMBL1210313,Q6W5P4,Neuropeptide S receptor,1.0,ORTHOGONAL,NO,CCC(C)(CCN1CCOCC1)N(CC2=Cc3ccccc3N(C)C2=O)C(=O)C4CCCCC4,2,16,"InChI=1S/C28H41N3O3/c1-4-28(2,14-15-30-16-18-34-19-17-30)31(27(33)22-10-6-5-7-11-22)21-24-20-23-12-8-9-13-25(23)29(3)26(24)32/h8-9,12-13,20,22H,4-7,10-11,14-19,21H2,1-3H3",FWHNGUFKFXDMER-UHFFFAOYSA-N,"c(""Neuropeptide S receptor"", ""P-glycoprotein 1"", ""Unchecked"")",387129,NPSR1,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-418555 G alpha (s) signalling events R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,IEA GO:0005737 cytoplasm TAS GO:0005886 plasma membrane 16790440 IDA GO:0005887 integral component of plasma membrane,neuropeptide signaling pathway GO:0007218 IEA positive regulation of release of sequestered calcium ion into cytosol 16790440 GO:0051281 IDA,vasopressin receptor activity IEA GO:0005000 neuropeptide receptor activity IDA 16790440 GO:0008188,,CHEMBL CHEMBL1474387,Q6W5P4,Neuropeptide S receptor,1.0,PRIMARY,NO,[Br-].Cc1c(n2ccccc2[n+]1C\C=C\c3ccccc3)P(=S)(c4ccccc4)c5ccccc5,2,17,"InChI=1S/C29H26N2PS.BrH/c1-24-29(32(33,26-17-7-3-8-18-26)27-19-9-4-10-20-27)31-22-12-11-21-28(31)30(24)23-13-16-25-14-5-2-6-15-25;/h2-22H,23H2,1H3;1H/q+1;/p-1/b16-13+;",CJAQCMBWGUOBIX-ZUQRMPMESA-M,"c(""Neuropeptide S receptor"", ""Nuclear factor erythroid 2-related factor 2"", ""HepG2"", ""Mothers against decapentaplegic homolog 3"", ""Unchecked"", ""Mu opioid receptor"", ""Parathyroid hormone receptor"")",387129,NPSR1,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-418555 G alpha (s) signalling events R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,IEA GO:0005737 cytoplasm TAS GO:0005886 plasma membrane 16790440 IDA GO:0005887 integral component of plasma membrane,neuropeptide signaling pathway GO:0007218 IEA positive regulation of release of sequestered calcium ion into cytosol 16790440 GO:0051281 IDA,vasopressin receptor activity IEA GO:0005000 neuropeptide receptor activity IDA 16790440 GO:0008188,,CHEMBL CHEMBL329536,P25929,Neuropeptide Y receptor type 1,1.0,ORTHOGONAL,NO,Clc1ccc(OCc2c(C(=O)CN3CCC(CC3)N4CCCCC4)c5ccccc5n2CCC[C@@H]6CCCNC6)cc1,4,7,"InChI=1S/C35H47ClN4O2/c36-28-12-14-30(15-13-28)42-26-33-35(34(41)25-38-22-16-29(17-23-38)39-19-4-1-5-20-39)31-10-2-3-11-32(31)40(33)21-7-9-27-8-6-18-37-24-27/h2-3,10-15,27,29,37H,1,4-9,16-26H2/t27-/m0/s1",XHHLNSWTGQCLAS-MHZLTWQESA-N,"c(""Neuropeptide Y receptor type 1"", ""SK-N-MC"", ""Neuropeptide Y receptor type 2"", ""Neuropeptide Y receptor type 4"", ""Neuropeptide Y receptor type 5"")",4886,NPY1R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,cytosol GO:0005829 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 1317848 TAS synaptic vesicle GO:0008021 IEA axon GO:0030424 IEA,"outflow tract morphogenesis IMP 19593212 GO:0003151 glucose metabolic process IEA GO:0006006 cell surface receptor signaling pathway IBA GO:0007166 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1317848 GO:0007187 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS 1321422 GO:0007193 neuropeptide signaling pathway IEA GO:0007218 locomotory behavior IEA GO:0007626 feeding behavior IBA GO:0007631 blood circulation IBA GO:0008015 regulation of blood pressure IEA GO:0008217 sensory perception of pain IEA GO:0019233 peristalsis IEA GO:0030432 response to estradiol IEA GO:0032355 regulation of multicellular organism growth IEA GO:0040014 positive regulation of vasoconstriction IEA GO:0045907 negative regulation of hormone secretion IEA GO:0046888 negative regulation of cytosolic calcium ion concentration IEA GO:0051481",GO:0001601 peptide YY receptor activity IEA GO:0001602 pancreatic polypeptide receptor activity IBA GO:0004983 neuropeptide Y receptor activity 1317848 TAS GO:0005515 protein binding 23597562 IPI,cAMP signaling pathway - Homo sapiens (human) hsa04024 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04923,CHEMBL CHEMBL332347,P25929,Neuropeptide Y receptor type 1,1.0,PRIMARY,NO,NC(=NCCC[C@@H](NC(=O)C(c1ccccc1)c2ccccc2)C(=O)NCc3ccc(O)cc3)N,4,26,"InChI=1S/C27H31N5O3/c28-27(29)30-17-7-12-23(25(34)31-18-19-13-15-22(33)16-14-19)32-26(35)24(20-8-3-1-4-9-20)21-10-5-2-6-11-21/h1-6,8-11,13-16,23-24,33H,7,12,17-18H2,(H,31,34)(H,32,35)(H4,28,29,30)/t23-/m1/s1",KUWBXRGRMQZCSS-HSZRJFAPSA-N,"c(""Neuropeptide Y receptor type 1"", ""Neuropeptide Y receptor type 2"", ""Neuropeptide Y receptor type 4"", ""Neuropeptide Y receptor type 5"", ""Neuropeptide FF receptor 2"", ""Neuropeptide FF receptor 1"")",4886,NPY1R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,cytosol GO:0005829 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 1317848 TAS synaptic vesicle GO:0008021 IEA axon GO:0030424 IEA,"outflow tract morphogenesis IMP 19593212 GO:0003151 glucose metabolic process IEA GO:0006006 cell surface receptor signaling pathway IBA GO:0007166 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 1317848 GO:0007187 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS 1321422 GO:0007193 neuropeptide signaling pathway IEA GO:0007218 locomotory behavior IEA GO:0007626 feeding behavior IBA GO:0007631 blood circulation IBA GO:0008015 regulation of blood pressure IEA GO:0008217 sensory perception of pain IEA GO:0019233 peristalsis IEA GO:0030432 response to estradiol IEA GO:0032355 regulation of multicellular organism growth IEA GO:0040014 positive regulation of vasoconstriction IEA GO:0045907 negative regulation of hormone secretion IEA GO:0046888 negative regulation of cytosolic calcium ion concentration IEA GO:0051481",GO:0001601 peptide YY receptor activity IEA GO:0001602 pancreatic polypeptide receptor activity IBA GO:0004983 neuropeptide Y receptor activity 1317848 TAS GO:0005515 protein binding 23597562 IPI,cAMP signaling pathway - Homo sapiens (human) hsa04024 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04923,CHEMBL CHEMBL2440185,P49146,Neuropeptide Y receptor type 2,1.0,ORTHOGONAL,NO,CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N,4,9,"InChI=1S/C75H120N26O18/c1-9-38(5)58(99-69(116)53(32-43-19-23-46(105)24-20-43)96-66(113)54(33-44-35-85-36-89-44)97-62(109)47(90-41(8)103)14-11-27-86-73(79)80)70(117)98-55(34-57(77)107)67(114)95-52(30-37(3)4)68(115)100-59(39(6)10-2)71(118)101-60(40(7)102)72(119)93-49(16-13-29-88-75(83)84)63(110)92-50(25-26-56(76)106)65(112)91-48(15-12-28-87-74(81)82)64(111)94-51(61(78)108)31-42-17-21-45(104)22-18-42/h17-24,35-40,47-55,58-60,102,104-105H,9-16,25-34H2,1-8H3,(H2,76,106)(H2,77,107)(H2,78,108)(H,85,89)(H,90,103)(H,91,112)(H,92,110)(H,93,119)(H,94,111)(H,95,114)(H,96,113)(H,97,109)(H,98,117)(H,99,116)(H,100,115)(H,101,118)(H4,79,80,86)(H4,81,82,87)(H4,83,84,88)/t38-,39-,40+,47-,48-,49-,50-,51-,52-,53-,54-,55-,58-,59-,60-/m0/s1",WIBSCJFYXUIBMU-DEMLLOIYSA-N,"c(""Neuropeptide Y receptor type 2"", ""Unchecked"", ""Neuropeptide Y receptor type 5"", ""Neuropeptide Y receptor type 1"", ""Neuropeptide Y receptor type 4"")",4887,NPY2R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,cytosol GO:0005829 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 IEA nonmotile primary cilium GO:0031513 IEA,"GO:0001662 behavioral fear response IEA GO:0002793 positive regulation of peptide secretion IEA GO:0003151 outflow tract morphogenesis 19593212 IMP GO:0003214 cardiac left ventricle morphogenesis 19593212 IMP GO:0007166 cell surface receptor signaling pathway IBA GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA GO:0007204 positive regulation of cytosolic calcium ion concentration IEA GO:0007218 neuropeptide signaling pathway IEA GO:0007263 nitric oxide mediated signal transduction IEA GO:0007268 chemical synaptic transmission IBA GO:0007626 locomotory behavior 9692752 TAS GO:0007631 feeding behavior IBA GO:0010811 positive regulation of cell-substrate adhesion IEA GO:0030818 negative regulation of cAMP biosynthetic process IEA GO:0031645 negative regulation of neurological system process IEA GO:0033603 positive regulation of dopamine secretion IEA GO:0045987 positive regulation of smooth muscle contraction IEA GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep IEA GO:0046903 secretion IEA GO:0051048 negative regulation of secretion IEA GO:0051930 regulation of sensory perception of pain IEA GO:0051967 negative regulation of synaptic transmission, glutamatergic IEA GO:0090394 negative regulation of excitatory postsynaptic potential IEA GO:2000252 negative regulation of feeding behavior IEA",peptide YY receptor activity GO:0001601 IEA receptor activity GO:0004872 TAS 1321422 neuropeptide Y receptor activity GO:0004983 TAS 7559383 calcium channel regulator activity GO:0005246 TAS 8132547 protein binding GO:0005515 IPI 23597562,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL2307889,P49146,Neuropeptide Y receptor type 2,1.0,PRIMARY,NO,NC(=N)NCCC[C@@H](NC(=O)CC1(CC(=O)N2CCN(CC2)C3c4ccccc4NC(=O)c5ccccc35)CCCC1)C(=O)NCCN6C(=O)N(N(C6=O)c7ccccc7)c8ccccc8,7,9,"InChI=1S/C49H57N11O6/c50-46(51)53-25-13-22-40(45(64)52-26-27-58-47(65)59(34-14-3-1-4-15-34)60(48(58)66)35-16-5-2-6-17-35)54-41(61)32-49(23-11-12-24-49)33-42(62)56-28-30-57(31-29-56)43-36-18-7-8-19-37(36)44(63)55-39-21-10-9-20-38(39)43/h1-10,14-21,40,43H,11-13,22-33H2,(H,52,64)(H,54,61)(H,55,63)(H4,50,51,53)/t40-,43?/m1/s1",RSJAXPUYVJKAAA-MJEROREJSA-N,"c(""Neuropeptide Y receptor type 2"", ""Neuropeptide Y receptor type 4"", ""Neuropeptide Y receptor type 5"", ""Neuropeptide Y receptor type 1"", ""Kappa opioid receptor"", ""Mu opioid receptor"", ""Alpha-1a adrenergic receptor"")",4887,NPY2R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,cytosol GO:0005829 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 IEA nonmotile primary cilium GO:0031513 IEA,"GO:0001662 behavioral fear response IEA GO:0002793 positive regulation of peptide secretion IEA GO:0003151 outflow tract morphogenesis 19593212 IMP GO:0003214 cardiac left ventricle morphogenesis 19593212 IMP GO:0007166 cell surface receptor signaling pathway IBA GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA GO:0007204 positive regulation of cytosolic calcium ion concentration IEA GO:0007218 neuropeptide signaling pathway IEA GO:0007263 nitric oxide mediated signal transduction IEA GO:0007268 chemical synaptic transmission IBA GO:0007626 locomotory behavior 9692752 TAS GO:0007631 feeding behavior IBA GO:0010811 positive regulation of cell-substrate adhesion IEA GO:0030818 negative regulation of cAMP biosynthetic process IEA GO:0031645 negative regulation of neurological system process IEA GO:0033603 positive regulation of dopamine secretion IEA GO:0045987 positive regulation of smooth muscle contraction IEA GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep IEA GO:0046903 secretion IEA GO:0051048 negative regulation of secretion IEA GO:0051930 regulation of sensory perception of pain IEA GO:0051967 negative regulation of synaptic transmission, glutamatergic IEA GO:0090394 negative regulation of excitatory postsynaptic potential IEA GO:2000252 negative regulation of feeding behavior IEA",peptide YY receptor activity GO:0001601 IEA receptor activity GO:0004872 TAS 1321422 neuropeptide Y receptor activity GO:0004983 TAS 7559383 calcium channel regulator activity GO:0005246 TAS 8132547 protein binding GO:0005515 IPI 23597562,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL408891,P50391,Neuropeptide Y receptor type 4,1.0,PRIMARY,NO,CCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc6ccc(O)cc6)C(=O)N,3,9,"InChI=1S/C74H107N25O12/c1-3-13-52(92-65(106)54(19-9-31-85-71(77)78)91-62(103)49(75)37-43-39-89-50-17-7-5-15-47(43)50)64(105)95-57(22-12-34-88-74(83)84)68(109)98-59(36-42-25-29-46(101)30-26-42)69(110)99-60(38-44-40-90-51-18-8-6-16-48(44)51)70(111)96-55(20-10-32-86-72(79)80)66(107)93-53(14-4-2)63(104)94-56(21-11-33-87-73(81)82)67(108)97-58(61(76)102)35-41-23-27-45(100)28-24-41/h5-8,15-18,23-30,39-40,49,52-60,89-90,100-101H,3-4,9-14,19-22,31-38,75H2,1-2H3,(H2,76,102)(H,91,103)(H,92,106)(H,93,107)(H,94,104)(H,95,105)(H,96,111)(H,97,108)(H,98,109)(H,99,110)(H4,77,78,85)(H4,79,80,86)(H4,81,82,87)(H4,83,84,88)/t49-,52-,53-,54-,55-,56-,57-,58-,59-,60-/m0/s1",QTWWWOBSQULXHE-MTVPJWGZSA-N,"c(""Neuropeptide Y receptor type 4"", ""Neuropeptide Y receptor type 1"", ""Neuropeptide Y receptor type 2"", ""Unchecked"")",100996758,NPY4R,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,,,,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL2440193,P50391,Neuropeptide Y receptor type 4,1.0,PRIMARY,YES,CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]3C[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H]4C[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc5ccc(O)cc5)C(=O)N)C4(C)C)C3(C)C,4,6,"InChI=1S/C80H127N25O16/c1-12-41(5)62(104-73(119)56(33-45-22-26-48(108)27-23-45)99-70(116)57(34-46-38-89-39-93-46)100-67(113)51(94-43(7)106)17-14-28-90-76(83)84)74(120)101-58(37-61(81)109)71(117)98-55(31-40(3)4)72(118)105-63(42(6)13-2)75(121)103-60-36-50(80(60,10)11)66(112)96-53(19-16-30-92-78(87)88)69(115)102-59-35-49(79(59,8)9)65(111)95-52(18-15-29-91-77(85)86)68(114)97-54(64(82)110)32-44-20-24-47(107)25-21-44/h20-27,38-42,49-60,62-63,107-108H,12-19,28-37H2,1-11H3,(H2,81,109)(H2,82,110)(H,89,93)(H,94,106)(H,95,111)(H,96,112)(H,97,114)(H,98,117)(H,99,116)(H,100,113)(H,101,120)(H,102,115)(H,103,121)(H,104,119)(H,105,118)(H4,83,84,90)(H4,85,86,91)(H4,87,88,92)/t41-,42-,49+,50+,51-,52-,53-,54-,55-,56-,57-,58-,59+,60+,62-,63-/m0/s1",MTFGLKCUHOHWPI-ZEOIPKQCSA-N,"c(""Neuropeptide Y receptor type 5"", ""Neuropeptide Y receptor type 2"", ""Neuropeptide Y receptor type 1"", ""Neuropeptide Y receptor type 4"")",100996758,NPY4R,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,,,,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL257940,Q15761,Neuropeptide Y receptor type 5,1.0,PRIMARY,NO,CN(C1CCN(CC1)C(=O)C)C(=O)N[C@@H]2CC[C@H](CC2)c3cc(F)cc(F)c3,14,19,"InChI=1S/C21H29F2N3O2/c1-14(27)26-9-7-20(8-10-26)25(2)21(28)24-19-5-3-15(4-6-19)16-11-17(22)13-18(23)12-16/h11-13,15,19-20H,3-10H2,1-2H3,(H,24,28)/t15-,19-",WZHXVKWOVBWNIB-RHDGDCLCSA-N,"c(""Neuropeptide Y receptor type 5"", ""Neuropeptide Y receptor type 1"", ""Neuropeptide Y receptor type 2"", ""Neuropeptide Y receptor type 4"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 2b (5-HT2b) receptor"", ""Serotonin 2c (5-HT2c) receptor"", ""Serotonin 3a (5-HT3a) receptor"", ""Serotonin 5a (5-HT5a) receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Serotonin 7 (5-HT7) receptor"", ""Norepinephrine transporter"", ""Dopamine transporter"", ""Serotonin transporter"", ""Unchecked"")",4889,NPY5R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,cytoplasm IEA GO:0005737 plasma membrane TAS GO:0005886 integral component of plasma membrane TAS 8824284 GO:0005887 neuron projection IEA GO:0043005,"IEA GO:0002675 positive regulation of acute inflammatory response IMP 19593212 outflow tract morphogenesis GO:0003151 IMP 19593212 cardiac left ventricle morphogenesis GO:0003214 IBA GO:0007166 cell surface receptor signaling pathway TAS 8824284 G-protein coupled receptor signaling pathway GO:0007186 IEA GO:0007218 neuropeptide signaling pathway IBA GO:0007268 chemical synaptic transmission IBA GO:0007631 feeding behavior IEA GO:0014050 negative regulation of glutamate secretion IEA GO:0032229 negative regulation of synaptic transmission, GABAergic IEA GO:0042755 eating behavior IEA GO:0043066 negative regulation of apoptotic process IEA GO:0048661 positive regulation of smooth muscle cell proliferation IEA GO:0060112 generation of ovulation cycle rhythm",IEA GO:0001601 peptide YY receptor activity IEA GO:0001602 pancreatic polypeptide receptor activity 8824284 TAS GO:0004983 neuropeptide Y receptor activity,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL506981,P30989,Neurotensin receptor 1,1.0,PRIMARY,YES,COc1cccc(OC)c1c2cc(nn2c3ccnc4cc(Cl)ccc34)C(=O)NC5(C6CC7CC(CC5C7)C6)C(=O)O,3,31,"InChI=1S/C32H31ClN4O5/c1-41-27-4-3-5-28(42-2)29(27)26-16-24(36-37(26)25-8-9-34-23-15-21(33)6-7-22(23)25)30(38)35-32(31(39)40)19-11-17-10-18(13-19)14-20(32)12-17/h3-9,15-20H,10-14H2,1-2H3,(H,35,38)(H,39,40)",DYLJVOXRWLXDIG-UHFFFAOYSA-N,"c(""Unchecked"", ""HT-29"", ""Neurotensin receptor 1"", ""Neurotensin receptor 3"", ""Neurotensin receptor 2"")",4923,NTR1,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,GO:0005739 mitochondrion IEA GO:0005783 endoplasmic reticulum IEA GO:0005794 Golgi apparatus IEA GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 8381365 IMP GO:0009898 cytoplasmic side of plasma membrane IEA GO:0009986 cell surface IEA GO:0032280 symmetric synapse IEA GO:0043195 terminal bouton IEA GO:0043197 dendritic spine IEA GO:0043198 dendritic shaft IEA GO:0043204 perikaryon IEA GO:0045121 membrane raft 21725197 IDA,IEA GO:0001659 temperature homeostasis IEA GO:0003085 negative regulation of systemic arterial blood pressure IEA GO:0003254 regulation of membrane depolarization 8381365 TAS GO:0007186 G-protein coupled receptor signaling pathway 21725197 IDA GO:0007218 neuropeptide signaling pathway 9763490 TAS GO:0007268 chemical synaptic transmission IEA GO:0007612 learning IEA GO:0008344 adult locomotory behavior IEA GO:0014049 positive regulation of glutamate secretion IEA GO:0014054 positive regulation of gamma-aminobutyric acid secretion IEA GO:0033993 response to lipid IEA GO:0043065 positive regulation of apoptotic process 21725197 IMP GO:0043066 negative regulation of apoptotic process IEA GO:0043576 regulation of respiratory gaseous exchange IEA GO:0050965 detection of temperature stimulus involved in sensory perception of pain IEA GO:0051280 negative regulation of release of sequestered calcium ion into cytosol IEA GO:0051281 positive regulation of release of sequestered calcium ion into cytosol IEA GO:0051930 regulation of sensory perception of pain IEA GO:0060732 positive regulation of inositol phosphate biosynthetic process IEA GO:0070779 D-aspartate import IEA GO:0071545 inositol phosphate catabolic process IEA GO:0090238 positive regulation of arachidonic acid secretion IEA GO:0097151 positive regulation of inhibitory postsynaptic potential IEA GO:0098900 regulation of action potential IEA GO:1990123 L-glutamate import into cell IEA GO:2001259 positive regulation of cation channel activity,G-protein coupled receptor activity GO:0004930 8381365 TAS protein binding GO:0005515 23597562 IPI G-protein coupled neurotensin receptor activity GO:0016492 21725197 IDA G-protein coupled neurotensin receptor activity GO:0016492 8381365 IMP protein homodimerization activity GO:0042803 IEA protein heterodimerization activity GO:0046982 IEA protein N-terminus binding GO:0047485 IEA,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL1766944,O95665,Neurotensin receptor 2,1.0,PRIMARY,NO,CC[C@H](C)[C@H](NC(=O)CN(CCc1ccc(O)cc1)C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)O,2,6,"InChI=1S/C39H66N10O8/c1-5-25(4)33(35(53)46-30(38(56)57)22-24(2)3)47-32(51)23-48(21-17-26-13-15-27(50)16-14-26)37(55)31-12-9-20-49(31)36(54)29(11-6-7-18-40)45-34(52)28(41)10-8-19-44-39(42)43/h13-16,24-25,28-31,33,50H,5-12,17-23,40-41H2,1-4H3,(H,45,52)(H,46,53)(H,47,51)(H,56,57)(H4,42,43,44)/t25-,28-,29-,30-,31-,33-/m0/s1",HNTMSUWIPLVWMX-KECVWQCXSA-N,"c(""Neurotensin receptor 1"", ""Neurotensin receptor 2"", ""Unchecked"")",23620,NTR2,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 TAS 9851594,cell surface receptor signaling pathway GO:0007166 9851594 TAS phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 IEA neuropeptide signaling pathway GO:0007218 IEA sensory perception GO:0007600 8795617 TAS regulation of membrane potential GO:0042391 IEA,G-protein coupled receptor activity 9851594 GO:0004930 TAS G-protein coupled neurotensin receptor activity GO:0016492 IEA,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL1762473,P35228,"Nitric oxide synthase, inducible",1.0,ORTHOGONAL,NO,NCC[C@@H](Oc1cc(Cl)ccc1C#N)c2ccccc2.OC(=O)C(=O)O,3,6,"InChI=1S/C16H15ClN2O.C2H2O4/c17-14-7-6-13(11-19)16(10-14)20-15(8-9-18)12-4-2-1-3-5-12;3-1(4)2(5)6/h1-7,10,15H,8-9,18H2;(H,3,4)(H,5,6)/t15-;/m1./s1",PPQGTHAGWWVLEX-XFULWGLBSA-N,"c(""Unchecked"", ""Norepinephrine transporter"", ""Serotonin transporter"", ""Nitric oxide synthase, inducible"")",4843,NOS2,Hemostasis R-HSA-109582 Latent infection of Homo sapiens with Mycobacterium tuberculosis R-HSA-1222352 Phagosomal maturation (early endosomal stage) R-HSA-1222556 Disease R-HSA-1643685 Nitric oxide stimulates guanylate cyclase R-HSA-392154 Platelet homeostasis R-HSA-418346 Infectious disease R-HSA-5663205,IDA 7544003 intracellular GO:0005622 ISS GO:0005634 nucleus IDA 9916929 12085352 cytoplasm GO:0005737 IDA 12085352 peroxisome GO:0005777 IMP 7504305 cytosol GO:0005829 TAS GO:0005829 cytosol IEA GO:0030863 cortical cytoskeleton IEA GO:0048471 perinuclear region of cytoplasm,response to hypoxia GO:0001666 IEA positive regulation of leukocyte mediated cytotoxicity 10450191 GO:0001912 TAS innate immune response in mucosa 18390757 GO:0002227 NAS arginine catabolic process 7504305 GO:0006527 IDA superoxide metabolic process GO:0006801 ISS nitric oxide biosynthetic process 7504305 7682706 GO:0006809 IDA nitric oxide mediated signal transduction GO:0007263 IBA circadian rhythm GO:0007623 IEA response to bacterium 12085352 GO:0009617 NAS negative regulation of gene expression 12085352 GO:0010629 IGI peptidyl-cysteine S-nitrosylation GO:0018119 ISS positive regulation of guanylate cyclase activity GO:0031284 IBA prostaglandin secretion 19688109 GO:0032310 IDA cellular response to drug GO:0035690 IEA regulation of cell proliferation GO:0042127 IEA negative regulation of protein catabolic process GO:0042177 IEA defense response to bacterium 9284131 GO:0042742 IMP defense response to bacterium GO:0042742 ISS regulation of cellular respiration 10450191 GO:0043457 TAS cell redox homeostasis GO:0045454 TAS negative regulation of blood pressure GO:0045776 IBA positive regulation of vasodilation GO:0045909 IBA regulation of insulin secretion 8383325 GO:0050796 IMP defense response to Gram-negative bacterium 18390757 GO:0050829 NAS positive regulation of killing of cells of other organism 7544003 GO:0051712 IMP oxidation-reduction process GO:0055114 IEA cellular response to lipopolysaccharide GO:0071222 IEA cellular response to interferon-gamma GO:0071346 IEA interleukin-6 secretion 19688109 GO:0072604 IDA interleukin-8 secretion 19688109 GO:0072606 IDA regulation of cytokine production involved in inflammatory response 19688109 GO:1900015 IDA,7504305 7682706 GO:0004517 nitric-oxide synthase activity IDA GO:0004517 nitric-oxide synthase activity TAS 20178365 GO:0005102 receptor binding IPI 12855682 25417112 GO:0005515 protein binding IPI GO:0005516 calmodulin binding IEA GO:0010181 FMN binding ISS GO:0020037 heme binding ISS GO:0034617 tetrahydrobiopterin binding ISS GO:0034618 arginine binding ISS GO:0042803 protein homodimerization activity ISS GO:0046872 metal ion binding IEA GO:0050660 flavin adenine dinucleotide binding ISS 7504305 GO:0050661 NADP binding TAS,hsa00220 Arginine biosynthesis - Homo sapiens (human) hsa00330 Arginine and proline metabolism - Homo sapiens (human) hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04146 Peroxisome - Homo sapiens (human) hsa05132 Salmonella infection - Homo sapiens (human) hsa05133 Pertussis - Homo sapiens (human) hsa05140 Leishmaniasis - Homo sapiens (human) hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05146 Amoebiasis - Homo sapiens (human) hsa05152 Tuberculosis - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05222 Small cell lung cancer - Homo sapiens (human),CHEMBL CHEMBL522771,P35228,"Nitric oxide synthase, inducible",1.0,PRIMARY,NO,Cc1ncsc1C(=O)N(CC2=CC(=O)Nc3c(F)cccc23)c4cccc(Cl)c4,3,8,"InChI=1S/C21H15ClFN3O2S/c1-12-20(29-11-24-12)21(28)26(15-5-2-4-14(22)9-15)10-13-8-18(27)25-19-16(13)6-3-7-17(19)23/h2-9,11H,10H2,1H3,(H,25,27)",UNXUBXXLEVFSIH-UHFFFAOYSA-N,"c(""Nitric oxide synthase, inducible"", ""Nitric-oxide synthase, endothelial"", ""Nitric-oxide synthase, brain"", ""Unchecked"")",4843,NOS2,Hemostasis R-HSA-109582 Latent infection of Homo sapiens with Mycobacterium tuberculosis R-HSA-1222352 Phagosomal maturation (early endosomal stage) R-HSA-1222556 Disease R-HSA-1643685 Nitric oxide stimulates guanylate cyclase R-HSA-392154 Platelet homeostasis R-HSA-418346 Infectious disease R-HSA-5663205,IDA 7544003 intracellular GO:0005622 ISS GO:0005634 nucleus IDA 9916929 12085352 cytoplasm GO:0005737 IDA 12085352 peroxisome GO:0005777 IMP 7504305 cytosol GO:0005829 TAS GO:0005829 cytosol IEA GO:0030863 cortical cytoskeleton IEA GO:0048471 perinuclear region of cytoplasm,response to hypoxia GO:0001666 IEA positive regulation of leukocyte mediated cytotoxicity 10450191 GO:0001912 TAS innate immune response in mucosa 18390757 GO:0002227 NAS arginine catabolic process 7504305 GO:0006527 IDA superoxide metabolic process GO:0006801 ISS nitric oxide biosynthetic process 7504305 7682706 GO:0006809 IDA nitric oxide mediated signal transduction GO:0007263 IBA circadian rhythm GO:0007623 IEA response to bacterium 12085352 GO:0009617 NAS negative regulation of gene expression 12085352 GO:0010629 IGI peptidyl-cysteine S-nitrosylation GO:0018119 ISS positive regulation of guanylate cyclase activity GO:0031284 IBA prostaglandin secretion 19688109 GO:0032310 IDA cellular response to drug GO:0035690 IEA regulation of cell proliferation GO:0042127 IEA negative regulation of protein catabolic process GO:0042177 IEA defense response to bacterium 9284131 GO:0042742 IMP defense response to bacterium GO:0042742 ISS regulation of cellular respiration 10450191 GO:0043457 TAS cell redox homeostasis GO:0045454 TAS negative regulation of blood pressure GO:0045776 IBA positive regulation of vasodilation GO:0045909 IBA regulation of insulin secretion 8383325 GO:0050796 IMP defense response to Gram-negative bacterium 18390757 GO:0050829 NAS positive regulation of killing of cells of other organism 7544003 GO:0051712 IMP oxidation-reduction process GO:0055114 IEA cellular response to lipopolysaccharide GO:0071222 IEA cellular response to interferon-gamma GO:0071346 IEA interleukin-6 secretion 19688109 GO:0072604 IDA interleukin-8 secretion 19688109 GO:0072606 IDA regulation of cytokine production involved in inflammatory response 19688109 GO:1900015 IDA,7504305 7682706 GO:0004517 nitric-oxide synthase activity IDA GO:0004517 nitric-oxide synthase activity TAS 20178365 GO:0005102 receptor binding IPI 12855682 25417112 GO:0005515 protein binding IPI GO:0005516 calmodulin binding IEA GO:0010181 FMN binding ISS GO:0020037 heme binding ISS GO:0034617 tetrahydrobiopterin binding ISS GO:0034618 arginine binding ISS GO:0042803 protein homodimerization activity ISS GO:0046872 metal ion binding IEA GO:0050660 flavin adenine dinucleotide binding ISS 7504305 GO:0050661 NADP binding TAS,hsa00220 Arginine biosynthesis - Homo sapiens (human) hsa00330 Arginine and proline metabolism - Homo sapiens (human) hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04146 Peroxisome - Homo sapiens (human) hsa05132 Salmonella infection - Homo sapiens (human) hsa05133 Pertussis - Homo sapiens (human) hsa05140 Leishmaniasis - Homo sapiens (human) hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05146 Amoebiasis - Homo sapiens (human) hsa05152 Tuberculosis - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05222 Small cell lung cancer - Homo sapiens (human),CHEMBL CHEMBL552338,P23975,Norepinephrine transporter,1.0,ORTHOGONAL,NO,FC(F)(F)c1ccccc1C(=O)N(CC2CCC2)[C@H]3CCNC3,6,14,"InChI=1S/C17H21F3N2O/c18-17(19,20)15-7-2-1-6-14(15)16(23)22(11-12-4-3-5-12)13-8-9-21-10-13/h1-2,6-7,12-13,21H,3-5,8-11H2/t13-/m0/s1",SWADTMSKMJUFBO-ZDUSSCGKSA-N,"c(""Unchecked"", ""Muscarinic acetylcholine receptor M4"", ""Muscarinic acetylcholine receptor M5"", ""Sodium channel protein type V alpha subunit"", ""Norepinephrine transporter"", ""Serotonin transporter"", ""Dopamine transporter"")",6530,SC6A2,"R-HSA-382551 Transmembrane transport of small molecules R-HSA-425366 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds R-HSA-425407 SLC-mediated transmembrane transport R-HSA-425428 Amine compound SLC transporters R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters",plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 IEA membrane GO:0016020 2008212 TAS neuron projection GO:0043005 IBA,2008212 GO:0006810 transport TAS 2008212 GO:0007268 chemical synaptic transmission TAS 16024787 GO:0015844 monoamine transport IDA GO:0015874 norepinephrine transport IBA GO:0048265 response to pain IEA GO:0051583 dopamine uptake involved in synaptic transmission IBA NOT GO:0055085 transmembrane transport IEA,NOT dopamine:sodium symporter activity IBA GO:0005330 norepinephrine:sodium symporter activity TAS GO:0005334 protein binding IPI 11343649 17156375 GO:0005515 monoamine transmembrane transporter activity IDA 16024787 GO:0008504 metal ion binding IEA GO:0046872,,CHEMBL CHEMBL478834,P23975,Norepinephrine transporter,1.0,PRIMARY,NO,CCOC(=O)N(Cc1ccccc1c2ccccc2)[C@H]3CCNC3,7,18,"InChI=1S/C20H24N2O2/c1-2-24-20(23)22(18-12-13-21-14-18)15-17-10-6-7-11-19(17)16-8-4-3-5-9-16/h3-11,18,21H,2,12-15H2,1H3/t18-/m0/s1",DRWJMJVERMOJBX-SFHVURJKSA-N,"c(""Norepinephrine transporter"", ""Serotonin transporter"", ""Dopamine transporter"", ""Muscarinic acetylcholine receptor M3"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 2b (5-HT2b) receptor"", ""Serotonin 2c (5-HT2c) receptor"", ""Unchecked"")",6530,SC6A2,"R-HSA-382551 Transmembrane transport of small molecules R-HSA-425366 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds R-HSA-425407 SLC-mediated transmembrane transport R-HSA-425428 Amine compound SLC transporters R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters",plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 IEA membrane GO:0016020 2008212 TAS neuron projection GO:0043005 IBA,2008212 GO:0006810 transport TAS 2008212 GO:0007268 chemical synaptic transmission TAS 16024787 GO:0015844 monoamine transport IDA GO:0015874 norepinephrine transport IBA GO:0048265 response to pain IEA GO:0051583 dopamine uptake involved in synaptic transmission IBA NOT GO:0055085 transmembrane transport IEA,NOT dopamine:sodium symporter activity IBA GO:0005330 norepinephrine:sodium symporter activity TAS GO:0005334 protein binding IPI 11343649 17156375 GO:0005515 monoamine transmembrane transporter activity IDA 16024787 GO:0008504 metal ion binding IEA GO:0046872,,CHEMBL CHEMBL3338865,O43614,Orexin receptor 2,1.0,PRIMARY,NO,COc1ccc(CNC(=O)c2cc(ncc2c3nccs3)c4cncc(C)c4)nc1OC,3,13,"InChI=1S/C23H21N5O3S/c1-14-8-15(11-24-10-14)19-9-17(18(13-26-19)23-25-6-7-32-23)21(29)27-12-16-4-5-20(30-2)22(28-16)31-3/h4-11,13H,12H2,1-3H3,(H,27,29)",VSOUDUXMPUHJEU-UHFFFAOYSA-N,"c(""Orexin receptor 2"", ""Orexin receptor 1"", ""Unchecked"", ""Pregnane X receptor"")",3062,OX2R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-389397 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,plasma membrane GO:0005886 TAS integral component of plasma membrane 9491897 GO:0005887 TAS,"phospholipase C-activating G-protein coupled receptor signaling pathway IEA GO:0007200 neuropeptide signaling pathway IEA GO:0007218 chemical synaptic transmission TAS 9491897 GO:0007268 feeding behavior IEA GO:0007631 circadian sleep/wake cycle process IEA GO:0022410 cellular response to hormone stimulus IBA GO:0032870 regulation of circadian sleep/wake cycle, sleep IBA GO:0045187 response to peptide IBA GO:1901652",GO:0008188 neuropeptide receptor activity 9491897 TAS GO:0016499 orexin receptor activity IBA GO:0017046 peptide hormone binding IEA GO:0042277 peptide binding IBA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL24781,P30559,Oxytocin receptor,1.0,ORTHOGONAL,NO,COc1cc(OC2CCN(CC2)C(=O)C)ccc1C(=O)N3CCC(CC3)N4C(=O)OCc5ccccc45,4,25,"InChI=1S/C28H33N3O6/c1-19(32)29-15-11-22(12-16-29)37-23-7-8-24(26(17-23)35-2)27(33)30-13-9-21(10-14-30)31-25-6-4-3-5-20(25)18-36-28(31)34/h3-8,17,21-22H,9-16,18H2,1-2H3",WDERJSQJYIJOPD-UHFFFAOYSA-N,"c(""Oxytocin receptor"", ""Vasopressin V1a receptor"", ""Serum albumin"", ""Vasopressin V2 receptor"", ""Unchecked"", ""Aldehyde dehydrogenase 1A1"")",5021,OXYR,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 Vasopressin-like receptors R-HSA-388479 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,GO:0005829 cytosol IEA GO:0005886 plasma membrane TAS 10858434 GO:0005887 integral component of plasma membrane TAS GO:0005902 microvillus IEA GO:0005913 cell-cell adherens junction IEA GO:0016324 apical plasma membrane IEA,"GO:0001967 suckling behavior IEA GO:0001975 response to amphetamine IEA GO:0001992 regulation of systemic arterial blood pressure by vasopressin IBA GO:0006936 muscle contraction 1313946 TAS GO:0007166 cell surface receptor signaling pathway 1313946 TAS GO:0007186 G-protein coupled receptor signaling pathway IEA GO:0007204 positive regulation of cytosolic calcium ion concentration IEA GO:0007507 heart development IEA GO:0007565 female pregnancy IEA GO:0007595 lactation 1313946 TAS GO:0007613 memory IEA GO:0010701 positive regulation of norepinephrine secretion IEA GO:0021537 telencephalon development IEA GO:0030431 sleep IEA GO:0032230 positive regulation of synaptic transmission, GABAergic IEA GO:0032355 response to estradiol IEA GO:0032570 response to progesterone IEA GO:0032870 cellular response to hormone stimulus IBA GO:0034059 response to anoxia IEA GO:0034097 response to cytokine IEA GO:0035176 social behavior IBA GO:0042220 response to cocaine IEA GO:0042493 response to drug IEA GO:0042711 maternal behavior IBA GO:0042713 sperm ejaculation IEA GO:0042755 eating behavior IEA GO:0043434 response to peptide hormone IEA GO:0044849 estrous cycle IEA GO:0045777 positive regulation of blood pressure IEA GO:0045907 positive regulation of vasoconstriction IBA GO:0048565 digestive tract development IEA GO:0051965 positive regulation of synapse assembly IEA GO:0051968 positive regulation of synaptic transmission, glutamatergic IEA GO:0060137 maternal process involved in parturition IEA GO:0060406 positive regulation of penile erection IEA GO:0060455 negative regulation of gastric acid secretion IEA GO:0070371 ERK1 and ERK2 cascade IEA GO:0070474 positive regulation of uterine smooth muscle contraction IEA GO:1901652 response to peptide IBA",oxytocin receptor activity GO:0004990 IEA vasopressin receptor activity GO:0005000 IBA peptide hormone binding GO:0017046 IEA peptide binding GO:0042277 IBA,Calcium signaling pathway - Homo sapiens (human) hsa04020 cAMP signaling pathway - Homo sapiens (human) hsa04024 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Oxytocin signaling pathway - Homo sapiens (human) hsa04921,CHEMBL CHEMBL594828,P30559,Oxytocin receptor,1.0,PRIMARY,NO,COCc1nnc(N2CC(C2)Oc3ccc(F)cc3Cl)n1c4ccc(OC)nc4,7,13,"InChI=1S/C19H19ClFN5O3/c1-27-11-17-23-24-19(26(17)13-4-6-18(28-2)22-8-13)25-9-14(10-25)29-16-5-3-12(21)7-15(16)20/h3-8,14H,9-11H2,1-2H3",HNIFCPBQMKPRCX-UHFFFAOYSA-N,"c(""Oxytocin receptor"", ""Vasopressin V1a receptor"", ""Vasopressin V2 receptor"", ""Neurokinin 1 receptor"", ""Kappa opioid receptor"", ""Ghrelin receptor"", ""Vasopressin V1b receptor"", ""Unchecked"")",5021,OXYR,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 Vasopressin-like receptors R-HSA-388479 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,GO:0005829 cytosol IEA GO:0005886 plasma membrane TAS 10858434 GO:0005887 integral component of plasma membrane TAS GO:0005902 microvillus IEA GO:0005913 cell-cell adherens junction IEA GO:0016324 apical plasma membrane IEA,"GO:0001967 suckling behavior IEA GO:0001975 response to amphetamine IEA GO:0001992 regulation of systemic arterial blood pressure by vasopressin IBA GO:0006936 muscle contraction 1313946 TAS GO:0007166 cell surface receptor signaling pathway 1313946 TAS GO:0007186 G-protein coupled receptor signaling pathway IEA GO:0007204 positive regulation of cytosolic calcium ion concentration IEA GO:0007507 heart development IEA GO:0007565 female pregnancy IEA GO:0007595 lactation 1313946 TAS GO:0007613 memory IEA GO:0010701 positive regulation of norepinephrine secretion IEA GO:0021537 telencephalon development IEA GO:0030431 sleep IEA GO:0032230 positive regulation of synaptic transmission, GABAergic IEA GO:0032355 response to estradiol IEA GO:0032570 response to progesterone IEA GO:0032870 cellular response to hormone stimulus IBA GO:0034059 response to anoxia IEA GO:0034097 response to cytokine IEA GO:0035176 social behavior IBA GO:0042220 response to cocaine IEA GO:0042493 response to drug IEA GO:0042711 maternal behavior IBA GO:0042713 sperm ejaculation IEA GO:0042755 eating behavior IEA GO:0043434 response to peptide hormone IEA GO:0044849 estrous cycle IEA GO:0045777 positive regulation of blood pressure IEA GO:0045907 positive regulation of vasoconstriction IBA GO:0048565 digestive tract development IEA GO:0051965 positive regulation of synapse assembly IEA GO:0051968 positive regulation of synaptic transmission, glutamatergic IEA GO:0060137 maternal process involved in parturition IEA GO:0060406 positive regulation of penile erection IEA GO:0060455 negative regulation of gastric acid secretion IEA GO:0070371 ERK1 and ERK2 cascade IEA GO:0070474 positive regulation of uterine smooth muscle contraction IEA GO:1901652 response to peptide IBA",oxytocin receptor activity GO:0004990 IEA vasopressin receptor activity GO:0005000 IBA peptide hormone binding GO:0017046 IEA peptide binding GO:0042277 IBA,Calcium signaling pathway - Homo sapiens (human) hsa04020 cAMP signaling pathway - Homo sapiens (human) hsa04024 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Oxytocin signaling pathway - Homo sapiens (human) hsa04921,CHEMBL CHEMBL3091630,P56373,P2X purinoceptor 3,1.0,PRIMARY,NO,Cc1nc(Cc2cccc(Oc3ccccc3)c2)c(\C=C\C(=O)O)c(C=O)c1O,2,5,"InChI=1S/C23H19NO5/c1-15-23(28)20(14-25)19(10-11-22(26)27)21(24-15)13-16-6-5-9-18(12-16)29-17-7-3-2-4-8-17/h2-12,14,28H,13H2,1H3,(H,26,27)/b11-10+",NRQMQLIOIVRYHC-ZHACJKMWSA-N,"c(""P2X purinoceptor 3"", ""Unchecked"", ""P2X purinoceptor 7"")",5024,P2RX3,,integral component of nuclear inner membrane IBA GO:0005639 rough endoplasmic reticulum IEA GO:0005791 Golgi apparatus IEA GO:0005794 plasma membrane TAS GO:0005886 integral component of plasma membrane IEA GO:0005887 neuronal cell body IEA GO:0043025 terminal bouton IEA GO:0043195 dendritic spine IEA GO:0043197 receptor complex IDA 23382219 GO:0043235 membrane raft IEA GO:0045121,response to hypoxia GO:0001666 IEA transport GO:0006810 TAS 9221902 signal transduction GO:0007165 TAS 9221902 neuromuscular synaptic transmission GO:0007274 IEA blood coagulation GO:0007596 TAS response to heat GO:0009408 IEA response to cold GO:0009409 IEA response to mechanical stimulus GO:0009612 IEA response to carbohydrate GO:0009743 IEA positive regulation of calcium ion transport into cytosol GO:0010524 NAS 17895406 urinary bladder smooth muscle contraction GO:0014832 IEA neuronal action potential GO:0019228 IEA peristalsis GO:0030432 IEA response to ATP GO:0033198 IEA purinergic nucleotide receptor signaling pathway GO:0035590 IEA regulation of synaptic plasticity GO:0048167 IEA positive regulation of calcium-mediated signaling GO:0050850 NAS 17895406 sensory perception of taste GO:0050909 IEA protein homooligomerization GO:0051260 IEA behavioral response to formalin induced pain GO:0061368 IEA cation transmembrane transport GO:0098655 IEA positive regulation of sensory perception of pain GO:1904058 IEA,IBA GO:0001614 purinergic nucleotide receptor activity NAS 17895406 purinergic nucleotide receptor activity GO:0001614 NAS 17895406 extracellular ATP-gated cation channel activity GO:0004931 NAS 17895406 ATP binding GO:0005524,Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL1163419,Q99571,P2X purinoceptor 4,1.0,PRIMARY,NO,Nc1ncnc2c1ncn2[C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@H]4OC5(O[C@@H]34)C(=CC(=[N+]([O-])[O-])C=C5[N+](=O)[O-])[N+](=O)[O-],2,14,"InChI=1S/C16H16N8O19P3/c17-13-10-14(19-4-18-13)21(5-20-10)15-12-11(7(39-15)3-38-45(34,35)43-46(36,37)42-44(31,32)33)40-16(41-12)8(23(27)28)1-6(22(25)26)2-9(16)24(29)30/h1-2,4-5,7,11-12,15H,3H2,(H6-,17,18,19,25,26,31,32,33,34,35,36,37)/q-1/t7-,11-,12-,15-/m1/s1",LQZBDVDATBCNNN-UHEGPQQHSA-N,"c(""P2X purinoceptor 1"", ""P2X purinoceptor 2"", ""P2X purinoceptor 3"", ""Unchecked"", ""Menin/Histone-lysine N-methyltransferase MLL"", ""Microtubule-associated protein tau"", ""Aldehyde dehydrogenase 1A1"", ""15-hydroxyprostaglandin dehydrogenase [NAD+]"", ""Vitamin D receptor"", ""DNA polymerase kappa"", ""P2X purinoceptor 4"")",5025,P2RX4,,GO:0005639 integral component of nuclear inner membrane IBA GO:0005765 lysosomal membrane 17897319 IDA GO:0005886 plasma membrane 17785580 ISS GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 11606481 IC GO:0005887 integral component of plasma membrane 10515189 IMP GO:0014069 postsynaptic density IEA GO:0016020 membrane 17785580 19946888 IDA GO:0030054 cell junction 12088286 IDA GO:0043025 neuronal cell body IEA GO:0043195 terminal bouton IEA GO:0043197 dendritic spine IEA GO:0048471 perinuclear region of cytoplasm 12088286 IDA GO:0070062 extracellular exosome 19056867 23533145 IDA,NAS 17264311 tissue homeostasis GO:0001894 ISS 17785580 regulation of sodium ion transport GO:0002028 IDA 9016352 transport GO:0006810 IDA 9016352 signal transduction GO:0007165 TAS GO:0007596 blood coagulation IMP 11606481 15130891 regulation of blood pressure GO:0008217 IDA 10969036 positive regulation of calcium ion transport into cytosol GO:0010524 IMP 10899068 positive regulation of calcium ion transport into cytosol GO:0010524 IMP 15130891 negative regulation of cardiac muscle hypertrophy GO:0010614 IEA GO:0019228 neuronal action potential ISS 14978347 sensory perception of pain GO:0019233 NAS 10899068 positive regulation of prostaglandin secretion GO:0032308 IDA 9016352 response to ATP GO:0033198 IDA 10515189 ion transmembrane transport GO:0034220 IDA 10969036 response to fluid shear stress GO:0034405 IMP 11606481 purinergic nucleotide receptor signaling pathway GO:0035590 TAS 12088286 endothelial cell activation GO:0042118 NAS 10899068 positive regulation of nitric oxide biosynthetic process GO:0045429 IDA 10969036 positive regulation of calcium-mediated signaling GO:0050850 IMP 10899068 positive regulation of calcium-mediated signaling GO:0050850 IEA GO:0051260 protein homooligomerization IDA 9016352 membrane depolarization GO:0051899 NAS 15130891 positive regulation of calcium ion transport GO:0051928 IMP 11606481 15130891 regulation of cardiac muscle contraction GO:0055117 IMP 11606481 15130891 relaxation of cardiac muscle GO:0055119 IDA 10515189 cellular response to ATP GO:0071318 IDA 17264311 apoptotic signaling pathway GO:0097190 IEA GO:0098655 cation transmembrane transport,9016352 IDA GO:0001614 purinergic nucleotide receptor activity 11606481 IMP GO:0001614 purinergic nucleotide receptor activity 9016352 10515189 IDA GO:0004931 extracellular ATP-gated cation channel activity 17785580 ISS GO:0005102 receptor binding 12819199 ISS GO:0005507 copper ion binding 25416956 IPI GO:0005515 protein binding 11606481 IC GO:0005524 ATP binding IEA GO:0008144 drug binding 12819199 ISS GO:0008270 zinc ion binding 17895406 NAS GO:0042803 protein homodimerization activity 12088286 IPI GO:0045296 cadherin binding,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL3236357,Q00987,p53-binding protein Mdm-2,1.0,PRIMARY,NO,CC(C)(C)S(=O)(=O)C[C@H](C1CC1)N2[C@@H]([C@H](C[C@](C)(Cc3ncc(CC(=O)O)s3)C2=O)c4cccc(Cl)c4)c5ccc(Cl)c(F)c5,2,9,"InChI=1S/C33H37Cl2FN2O5S2/c1-32(2,3)45(42,43)18-27(19-8-9-19)38-30(21-10-11-25(35)26(36)13-21)24(20-6-5-7-22(34)12-20)15-33(4,31(38)41)16-28-37-17-23(44-28)14-29(39)40/h5-7,10-13,17,19,24,27,30H,8-9,14-16,18H2,1-4H3,(H,39,40)/t24-,27-,30-,33-/m1/s1",HNLHOKSDTBAERS-CWIPYCOQSA-N,"c(""p53-binding protein Mdm-2"", ""SJSA-1"", ""Unchecked"", ""Protein Mdm4"")",4193,MDM2,"R-HSA-112314 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1280218 Adaptive Immune System R-HSA-1433557 Signaling by SCF-KIT R-HSA-162582 Signal Transduction R-HSA-1640170 Cell Cycle R-HSA-1643685 Disease R-HSA-166520 Signalling by NGF R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-177929 Signaling by EGFR R-HSA-180292 GAB1 signalosome R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-190236 Signaling by FGFR R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-198323 AKT phosphorylates targets in the cytosol R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2262752 Cellular responses to stress R-HSA-2424491 DAP12 signaling R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2559580 Oxidative Stress Induced Senescence R-HSA-2559583 Cellular Senescence R-HSA-2559585 Oncogene Induced Senescence R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-399719 Trafficking of AMPA receptors R-HSA-399721 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5663202 Diseases of signal transduction R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer R-HSA-69541 Stabilization of p53 R-HSA-69563 p53-Dependent G1 DNA Damage Response R-HSA-69580 p53-Dependent G1/S DNA damage checkpoint R-HSA-69615 G1/S DNA Damage Checkpoints R-HSA-69620 Cell Cycle Checkpoints R-HSA-983705 Signaling by the B Cell Receptor (BCR)",nucleus GO:0005634 IDA 10360174 nucleus GO:0005634 IMP 21726810 nucleoplasm GO:0005654 IDA 10707090 12915590 nucleoplasm GO:0005654 TAS nucleolus GO:0005730 IDA 10707090 22869143 cytoplasm GO:0005737 IMP 21726810 cytosol GO:0005829 TAS plasma membrane GO:0005886 TAS nuclear body GO:0016604 colocalizes_with IDA 10360174 endocytic vesicle membrane GO:0030666 TAS protein complex GO:0043234 IDA 9529249 synapse GO:0045202 IEA,"9271120 IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0001568 blood vessel development IEA GO:0001974 blood vessel remodeling IEA GO:0002027 regulation of heart rate IEA GO:0003181 atrioventricular valve morphogenesis IEA GO:0003203 endocardial cushion morphogenesis IEA GO:0003281 ventricular septum development IEA GO:0003283 atrial septum development 10608892 12915590 IDA GO:0006461 protein complex assembly 21726810 IMP GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IEA GO:0007089 traversing start control point of mitotic cell cycle 7791904 TAS GO:0008284 positive regulation of cell proliferation IEA GO:0009743 response to carbohydrate IEA GO:0010039 response to iron ion IEA GO:0010628 positive regulation of gene expression IEA GO:0010955 negative regulation of protein processing IEA GO:0016032 viral process 9450543 15878855 19656744 20153724 IDA GO:0016567 protein ubiquitination TAS GO:0016925 protein sumoylation 19372219 IMP GO:0018205 peptidyl-lysine modification 9529249 10360174 IDA GO:0031648 protein destabilization IEA GO:0032026 response to magnesium ion 11278372 IDA GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 10360174 IDA GO:0034504 protein localization to nucleus 9153395 IDA GO:0042176 regulation of protein catabolic process IEA GO:0042220 response to cocaine IEA GO:0042493 response to drug 11278372 16173922 IDA GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process 24506068 IMP GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IEA GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA GO:0043278 response to morphine 9529249 10360174 IDA GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator 10360174 IDA GO:0045184 establishment of protein localization IEA GO:0045472 response to ether 9271120 IDA GO:0045892 negative regulation of transcription, DNA-templated 17290220 IMP GO:0045931 positive regulation of mitotic cell cycle 20810912 IEP GO:0046677 response to antibiotic IEA GO:0046827 positive regulation of protein export from nucleus IEA GO:0060411 cardiac septum morphogenesis IEA GO:0070301 cellular response to hydrogen peroxide 9529249 IDA GO:0071157 negative regulation of cell cycle arrest IEA GO:0071236 cellular response to antibiotic IEA GO:0071301 cellular response to vitamin B1 IEA GO:0071312 cellular response to alkaloid IEA GO:0071363 cellular response to growth factor stimulus IEA GO:0071375 cellular response to peptide hormone stimulus IEA GO:0071391 cellular response to estrogen stimulus 20810912 IEP GO:0071456 cellular response to hypoxia IEA GO:0071494 cellular response to UV-C TAS GO:1901796 regulation of signal transduction by p53 class mediator 16173922 IDA GO:1901797 negative regulation of signal transduction by p53 class mediator",p53 binding GO:0002039 9529249 15053879 20173098 IPI ubiquitin-protein transferase activity GO:0004842 9450543 IDA ubiquitin-protein transferase activity GO:0004842 20173098 IMP ubiquitin-protein transferase activity GO:0004842 TAS protein binding GO:0005515 8875929 9271120 9529249 10196247 10608892 11178989 12740913 12915590 15144954 15195100 15313915 15364927 15604276 15878855 15916963 16023600 16173922 16374512 16474402 16845383 17006543 17110929 17139261 17159902 17170761 17268548 17290220 17310983 17347673 17373842 17875722 17909018 17936559 18309296 18332867 18485870 18566590 18583933 19098711 19166840 19166854 19249676 19369353 19372219 19411066 19483087 19656744 19713960 19833129 20195357 20591429 20598683 20708156 20713054 20856200 20871633 21132010 21170087 21333377 21399665 21460856 21726810 21988832 22085928 22103682 22124327 22493164 22510990 22575647 22653443 22659184 22819825 22869143 22975381 23092970 23260144 23397142 23507139 23776060 25241761 IPI zinc ion binding GO:0008270 10722742 IDA ligase activity GO:0016874 17142452 IDA SUMO transferase activity GO:0019789 21900752 EXP enzyme binding GO:0019899 15577914 17290220 18566590 20173098 IPI ubiquitin protein ligase binding GO:0031625 18382127 IPI identical protein binding GO:0042802 17159902 17936559 22493164 IPI peroxisome proliferator activated receptor binding GO:0042975 IEA ubiquitin protein ligase activity GO:0061630 19372219 IMP ubiquitin protein ligase activity GO:0061630 TAS scaffold protein binding GO:0097110 IEA,FoxO signaling pathway - Homo sapiens (human) hsa04068 Cell cycle - Homo sapiens (human) hsa04110 p53 signaling pathway - Homo sapiens (human) hsa04115 Ubiquitin mediated proteolysis - Homo sapiens (human) hsa04120 Endocytosis - Homo sapiens (human) hsa04144 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04919 Epstein-Barr virus infection - Homo sapiens (human) hsa05169 Pathways in cancer - Homo sapiens (human) hsa05200 Transcriptional misregulation in cancer - Homo sapiens (human) hsa05202 Viral carcinogenesis - Homo sapiens (human) hsa05203 Proteoglycans in cancer - Homo sapiens (human) hsa05205 MicroRNAs in cancer - Homo sapiens (human) hsa05206 Glioma - Homo sapiens (human) hsa05214 Prostate cancer - Homo sapiens (human) hsa05215 Melanoma - Homo sapiens (human) hsa05218 Bladder cancer - Homo sapiens (human) hsa05219 Chronic myeloid leukemia - Homo sapiens (human) hsa05220,CHEMBL CHEMBL1522313,P55201,Peregrin,1.0,PRIMARY,NO,COc1ccccc1C(=O)Nc2cc3N(C)C(=O)N(C)c3cc2N4CCCCC4,5,14,"InChI=1S/C22H26N4O3/c1-24-18-13-16(23-21(27)15-9-5-6-10-20(15)29-3)17(26-11-7-4-8-12-26)14-19(18)25(2)22(24)28/h5-6,9-10,13-14H,4,7-8,11-12H2,1-3H3,(H,23,27)",LTUGYAOMCKNTGG-UHFFFAOYSA-N,"c(""Microtubule-associated protein tau"", ""Lysine-specific demethylase 4A"", ""Bromodomain adjacent to zinc finger domain protein 2B"", ""Isocitrate dehydrogenase [NADP] cytoplasmic"", ""Unchecked"", ""Ubiquitin carboxyl-terminal hydrolase 1"", ""Bromodomain-containing protein 4"", ""Peregrin"", ""Bromodomain-containing protein 1"", ""Bromodomain and PHD finger-containing protein 3"")",7862,BRPF1,R-HSA-3214847 HATs acetylate histones R-HSA-3247509 Chromatin modifying enzymes R-HSA-4839726 Chromatin organization,IDA 18794358 nucleus GO:0005634 TAS GO:0005654 nucleoplasm IEA GO:0005737 cytoplasm IDA 16387653 18794358 MOZ/MORF histone acetyltransferase complex GO:0070776,"transcription, DNA-templated GO:0006351 IEA histone H3 acetylation GO:0043966 16387653 IDA positive regulation of transcription, DNA-templated GO:0045893 18794358 IDA regulation of signal transduction by p53 class mediator GO:1901796 TAS",DNA binding GO:0003677 IEA protein binding 25281266 GO:0005515 IPI zinc ion binding GO:0008270 IEA,,CHEMBL CHEMBL3264932,Q07869,Peroxisome proliferator-activated receptor alpha,1.0,PRIMARY,NO,CCN1C(=NN(Cc2ccc(cc2)C(C)(C)C)C1=O)CCCc3ccc(cc3)c4ccc(NS(=O)(=O)c5ccccc5)cn4,6,8,"InChI=1S/C35H39N5O3S/c1-5-39-33(37-40(34(39)41)25-27-16-20-29(21-17-27)35(2,3)4)13-9-10-26-14-18-28(19-15-26)32-23-22-30(24-36-32)38-44(42,43)31-11-7-6-8-12-31/h6-8,11-12,14-24,38H,5,9-10,13,25H2,1-4H3",IRSFLNXJVJKMDT-UHFFFAOYSA-N,"c(""Peroxisome proliferator-activated receptor alpha"", ""Peroxisome proliferator-activated receptor delta"", ""Peroxisome proliferator-activated receptor gamma"", ""Estrogen receptor beta"", ""Glucocorticoid receptor"", ""Thyroid hormone receptor beta-1"")",5465,PPARA,"BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1368108 Metabolism R-HSA-1430728 Generic Transcription Pathway R-HSA-212436 Nuclear Receptor transcription pathway R-HSA-383280 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-400206 Circadian Clock R-HSA-400253 Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-535734 Metabolism of lipids and lipoproteins R-HSA-556833 Gene Expression R-HSA-74160",16271724 TAS GO:0005634 nucleus TAS GO:0005654 nucleoplasm,"negative regulation of transcription from RNA polymerase II promoter 9748239 12700342 GO:0000122 IDA response to hypoxia GO:0001666 IEA transcription initiation from RNA polymerase II promoter GO:0006367 TAS lipid metabolic process 7684926 9792666 GO:0006629 TAS fatty acid metabolic process GO:0006631 IEA heart development GO:0007507 IEA epidermis development GO:0008544 IEA negative regulation of macrophage derived foam cell differentiation 12700342 GO:0010745 IC negative regulation of macrophage derived foam cell differentiation 19114110 GO:0010745 IDA negative regulation of receptor biosynthetic process 12700342 GO:0010871 IDA negative regulation of cholesterol storage 19114110 GO:0010887 IDA negative regulation of sequestering of triglyceride 12700342 GO:0010891 IDA fatty acid transport 16271724 GO:0015908 TAS intracellular receptor signaling pathway GO:0030522 IEA positive regulation of fatty acid beta-oxidation 16271724 GO:0032000 TAS negative regulation of protein binding GO:0032091 IEA negative regulation of appetite GO:0032099 ISS response to insulin GO:0032868 IEA circadian regulation of gene expression GO:0032922 ISS behavioral response to nicotine GO:0035095 IEA wound healing GO:0042060 IEA lipoprotein metabolic process GO:0042157 IEA regulation of circadian rhythm GO:0042752 ISS steroid hormone mediated signaling pathway GO:0043401 IEA cellular lipid metabolic process GO:0044255 TAS positive regulation of gluconeogenesis GO:0045722 IEA negative regulation of blood pressure GO:0045776 IEA negative regulation of glycolytic process 19955185 GO:0045820 IC positive regulation of transcription, DNA-templated 12955147 GO:0045893 IDA positive regulation of transcription from RNA polymerase II promoter 9748239 19955185 20837115 GO:0045944 IDA positive regulation of fatty acid oxidation GO:0046321 ISS negative regulation of inflammatory response 21636785 GO:0050728 IDA enamel mineralization GO:0070166 IEA regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter 19955185 GO:0072363 IDA regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter 19955185 GO:0072366 IDA regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter 19955185 GO:0072369 IDA negative regulation of neuron death GO:1901215 IEA negative regulation of pri-miRNA transcription from RNA polymerase II promoter 21636785 GO:1902894 IDA negative regulation of leukocyte cell-cell adhesion 21636785 GO:1903038 IDA negative regulation of transcription regulatory region DNA binding GO:2000678 IEA","9748239 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 9748239 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 9748239 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 19955185 GO:0001103 RNA polymerase II repressing transcription factor binding IPI GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IEA GO:0001223 transcription coactivator binding IEA 10860941 GO:0003677 DNA binding TAS 19955185 GO:0003700 transcription factor activity, sequence-specific DNA binding IDA GO:0003700 transcription factor activity, sequence-specific DNA binding ISS 19955185 GO:0003707 steroid hormone receptor activity IDA 12955147 19955185 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IDA 9653119 11915042 16554032 19955185 24043310 25814554 GO:0005515 protein binding IPI 9113987 12955147 GO:0008144 drug binding IDA GO:0008270 zinc ion binding IEA 12955147 GO:0008289 lipid binding IDA GO:0019902 phosphatase binding IEA GO:0019904 protein domain specific binding IEA 19955185 GO:0031624 ubiquitin conjugating enzyme binding IPI GO:0032403 protein complex binding IEA GO:0043565 sequence-specific DNA binding ISS GO:0051525 NFAT protein binding IEA GO:0097371 MDM2/MDM4 family protein binding IEA",hsa03320 PPAR signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) hsa04922 Glucagon signaling pathway - Homo sapiens (human) hsa04932 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human),CHEMBL CHEMBL21241,Q07869,Peroxisome proliferator-activated receptor alpha,1.0,PRIMARY,YES,CC(C)(Sc1ccc(CCN(CCCCC2CCCCC2)C(=O)NC3CCCCC3)cc1)C(=O)O,9,149,"InChI=1S/C29H46N2O3S/c1-29(2,27(32)33)35-26-18-16-24(17-19-26)20-22-31(28(34)30-25-14-7-4-8-15-25)21-10-9-13-23-11-5-3-6-12-23/h16-19,23,25H,3-15,20-22H2,1-2H3,(H,30,34)(H,32,33)",PKNYXWMTHFMHKD-UHFFFAOYSA-N,"c(""Peroxisome proliferator-activated receptor alpha"", ""Peroxisome proliferator-activated receptor gamma"", ""Peroxisome proliferator-activated receptor delta"", ""Unchecked"", ""Prelamin-A/C"", ""Breast cancer type 1 susceptibility protein"", ""Nuclear factor NF-kappa-B p105 subunit"", ""Endoplasmic reticulum-associated amyloid beta-peptide-binding protein"", ""ATP-dependent DNA helicase Q1"", ""Caspase-7"", ""Tyrosyl-DNA phosphodiesterase 1"", ""Microtubule-associated protein tau"", ""Hypoxia-inducible factor 1 alpha"", ""Aldehyde dehydrogenase 1A1"", ""Peripheral myelin protein 22"", ""Arachidonate 15-lipoxygenase"", ""MAP kinase ERK2"", ""Bloom syndrome protein"", ""Cellular tumor antigen p53"", ""Neuropeptide S receptor"", ""DNA polymerase beta"", ""Ubiquitin carboxyl-terminal hydrolase 2"", ""Geminin"", ""ATPase family AAA domain-containing protein 5"", ""Nuclear factor erythroid 2-related factor 2"", ""Lysine-specific demethylase 4A"", ""Dopamine D1 receptor"", ""Histone acetyltransferase GCN5"", ""M-phase phosphoprotein 8"", ""Histone-lysine N-methyltransferase, H3 lysine-9 specific 3"", ""Chromobox protein homolog 1"", ""Bromodomain adjacent to zinc finger domain protein 2B"", ""Arachidonate 15-lipoxygenase, type II"", ""Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1"", ""Vitamin D receptor"", ""Retinoid X receptor alpha"", ""Estrogen receptor alpha"", ""Thyroid hormone receptor beta-1"", ""Bile acid receptor FXR"", ""DNA polymerase iota"", ""Glucocorticoid receptor"", ""Ubiquitin carboxyl-terminal hydrolase 1"", ""Flap endonuclease 1"", ""DNA polymerase eta"", ""HepG2"", ""DNA polymerase kappa"", ""Regulator of G-protein signaling 4"", ""78 kDa glucose-regulated protein"", ""Ataxin-2"", ""Transcriptional regulator ERG"", ""No relevant target"", ""Pregnane X receptor"", ""Tyrosine-protein kinase YES"", ""Rap guanine nucleotide exchange factor 4"", ""Serine/threonine-protein kinase PLK1"", ""NAD-dependent protein deacylase sirtuin-5, mitochondrial"")",5465,PPARA,"BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1368108 Metabolism R-HSA-1430728 Generic Transcription Pathway R-HSA-212436 Nuclear Receptor transcription pathway R-HSA-383280 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-400206 Circadian Clock R-HSA-400253 Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-535734 Metabolism of lipids and lipoproteins R-HSA-556833 Gene Expression R-HSA-74160",16271724 TAS GO:0005634 nucleus TAS GO:0005654 nucleoplasm,"negative regulation of transcription from RNA polymerase II promoter 9748239 12700342 GO:0000122 IDA response to hypoxia GO:0001666 IEA transcription initiation from RNA polymerase II promoter GO:0006367 TAS lipid metabolic process 7684926 9792666 GO:0006629 TAS fatty acid metabolic process GO:0006631 IEA heart development GO:0007507 IEA epidermis development GO:0008544 IEA negative regulation of macrophage derived foam cell differentiation 12700342 GO:0010745 IC negative regulation of macrophage derived foam cell differentiation 19114110 GO:0010745 IDA negative regulation of receptor biosynthetic process 12700342 GO:0010871 IDA negative regulation of cholesterol storage 19114110 GO:0010887 IDA negative regulation of sequestering of triglyceride 12700342 GO:0010891 IDA fatty acid transport 16271724 GO:0015908 TAS intracellular receptor signaling pathway GO:0030522 IEA positive regulation of fatty acid beta-oxidation 16271724 GO:0032000 TAS negative regulation of protein binding GO:0032091 IEA negative regulation of appetite GO:0032099 ISS response to insulin GO:0032868 IEA circadian regulation of gene expression GO:0032922 ISS behavioral response to nicotine GO:0035095 IEA wound healing GO:0042060 IEA lipoprotein metabolic process GO:0042157 IEA regulation of circadian rhythm GO:0042752 ISS steroid hormone mediated signaling pathway GO:0043401 IEA cellular lipid metabolic process GO:0044255 TAS positive regulation of gluconeogenesis GO:0045722 IEA negative regulation of blood pressure GO:0045776 IEA negative regulation of glycolytic process 19955185 GO:0045820 IC positive regulation of transcription, DNA-templated 12955147 GO:0045893 IDA positive regulation of transcription from RNA polymerase II promoter 9748239 19955185 20837115 GO:0045944 IDA positive regulation of fatty acid oxidation GO:0046321 ISS negative regulation of inflammatory response 21636785 GO:0050728 IDA enamel mineralization GO:0070166 IEA regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter 19955185 GO:0072363 IDA regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter 19955185 GO:0072366 IDA regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter 19955185 GO:0072369 IDA negative regulation of neuron death GO:1901215 IEA negative regulation of pri-miRNA transcription from RNA polymerase II promoter 21636785 GO:1902894 IDA negative regulation of leukocyte cell-cell adhesion 21636785 GO:1903038 IDA negative regulation of transcription regulatory region DNA binding GO:2000678 IEA","9748239 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 9748239 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 9748239 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 19955185 GO:0001103 RNA polymerase II repressing transcription factor binding IPI GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding IEA GO:0001223 transcription coactivator binding IEA 10860941 GO:0003677 DNA binding TAS 19955185 GO:0003700 transcription factor activity, sequence-specific DNA binding IDA GO:0003700 transcription factor activity, sequence-specific DNA binding ISS 19955185 GO:0003707 steroid hormone receptor activity IDA 12955147 19955185 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IDA 9653119 11915042 16554032 19955185 24043310 25814554 GO:0005515 protein binding IPI 9113987 12955147 GO:0008144 drug binding IDA GO:0008270 zinc ion binding IEA 12955147 GO:0008289 lipid binding IDA GO:0019902 phosphatase binding IEA GO:0019904 protein domain specific binding IEA 19955185 GO:0031624 ubiquitin conjugating enzyme binding IPI GO:0032403 protein complex binding IEA GO:0043565 sequence-specific DNA binding ISS GO:0051525 NFAT protein binding IEA GO:0097371 MDM2/MDM4 family protein binding IEA",hsa03320 PPAR signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) hsa04922 Glucagon signaling pathway - Homo sapiens (human) hsa04932 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human),CHEMBL CHEMBL1644614,Q03181,Peroxisome proliferator-activated receptor delta,1.0,ORTHOGONAL,NO,CC(C)c1oc(nc1CCc2noc3cc(OCC(=O)O)c(C)cc23)c4ccc(Cl)cc4Cl,3,11,"InChI=1S/C24H22Cl2N2O5/c1-12(2)23-19(27-24(32-23)15-5-4-14(25)9-17(15)26)7-6-18-16-8-13(3)20(31-11-22(29)30)10-21(16)33-28-18/h4-5,8-10,12H,6-7,11H2,1-3H3,(H,29,30)",JDTVEJCQPMSSOE-UHFFFAOYSA-N,"c(""Peroxisome proliferator-activated receptor alpha"", ""Unchecked"", ""Peroxisome proliferator-activated receptor gamma"", ""Peroxisome proliferator-activated receptor delta"")",5467,PPARD,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1430728 Metabolism R-HSA-162582 Signal Transduction R-HSA-200425 Import of palmitoyl-CoA into the mitochondrial matrix R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-212436 Generic Transcription Pathway R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-535734 Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-5362517 Signaling by Retinoic Acid R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-70268 Pyruvate metabolism R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-74160 Gene Expression",nuclear chromatin GO:0000790 ISS nucleus GO:0005634 11551955 NAS nucleoplasm GO:0005654 TAS,"GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS 15793256 GO:0006006 glucose metabolic process NAS GO:0006029 proteoglycan metabolic process IEA 1333051 GO:0006091 generation of precursor metabolites and energy TAS 1333051 GO:0006357 regulation of transcription from RNA polymerase II promoter TAS GO:0006367 transcription initiation from RNA polymerase II promoter TAS GO:0006629 lipid metabolic process ISS GO:0006635 fatty acid beta-oxidation ISS 15192438 15803109 GO:0006635 fatty acid beta-oxidation TAS GO:0006776 vitamin A metabolic process IEA 12909723 GO:0006915 apoptotic process IMP GO:0007507 heart development IEA 11551955 GO:0007566 embryo implantation TAS 15192438 GO:0008203 cholesterol metabolic process TAS GO:0008283 cell proliferation ISS 11847022 GO:0008283 cell proliferation TAS GO:0008366 axon ensheathment ISS GO:0008654 phospholipid biosynthetic process IEA 15192438 GO:0009062 fatty acid catabolic process TAS GO:0009299 mRNA transcription IEA GO:0009749 response to glucose IEA GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA GO:0014823 response to activity IEA GO:0014842 regulation of skeletal muscle satellite cell proliferation IEA GO:0014912 negative regulation of smooth muscle cell migration IEA 15793256 GO:0015758 glucose transport NAS GO:0015908 fatty acid transport ISS GO:0030154 cell differentiation IEA GO:0030308 negative regulation of cell growth IEA GO:0030522 intracellular receptor signaling pathway IEA GO:0031589 cell-substrate adhesion IEA GO:0032024 positive regulation of insulin secretion IEA GO:0032966 negative regulation of collagen biosynthetic process IEA GO:0033189 response to vitamin A IEA GO:0042060 wound healing IEA GO:0043066 negative regulation of apoptotic process IEA GO:0043401 steroid hormone mediated signaling pathway IEA GO:0043415 positive regulation of skeletal muscle tissue regeneration IEA GO:0043616 keratinocyte proliferation IEA 10991946 GO:0045600 positive regulation of fat cell differentiation NAS GO:0045662 negative regulation of myoblast differentiation IEA GO:0045684 positive regulation of epidermis development IEA GO:0045892 negative regulation of transcription, DNA-templated ISS 12955147 GO:0045893 positive regulation of transcription, DNA-templated IDA GO:0045909 positive regulation of vasodilation IEA 11551955 GO:0046697 decidualization TAS GO:0048662 negative regulation of smooth muscle cell proliferation IEA GO:0050680 negative regulation of epithelial cell proliferation IEA GO:0050728 negative regulation of inflammatory response IEA GO:0051546 keratinocyte migration IEA GO:0060612 adipose tissue development IEA GO:0071222 cellular response to lipopolysaccharide IEA GO:0071456 cellular response to hypoxia IEA 11551955 GO:0097190 apoptotic signaling pathway IMP GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter ISS GO:2000288 positive regulation of myoblast proliferation IEA","transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding ISS GO:0001227 DNA binding ISS GO:0003677 transcription factor activity, sequence-specific DNA binding IDA 12955147 GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 11551955 GO:0003700 steroid hormone receptor activity IEA GO:0003707 transcription coactivator activity IEA GO:0003713 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IDA 12955147 GO:0004879 protein binding IPI 23455924 GO:0005515 drug binding IDA 9113987 10198642 GO:0008144 zinc ion binding IEA GO:0008270 lipid binding IDA 12955147 GO:0008289 sequence-specific DNA binding IEA GO:0043565 protein heterodimerization activity IEA GO:0046982 NF-kappaB binding IEA GO:0051059 linoleic acid binding IDA 10198642 GO:0070539",PPAR signaling pathway - Homo sapiens (human) hsa03320 Wnt signaling pathway - Homo sapiens (human) hsa04310 Pathways in cancer - Homo sapiens (human) hsa05200 Acute myeloid leukemia - Homo sapiens (human) hsa05221,CHEMBL CHEMBL38508,Q03181,Peroxisome proliferator-activated receptor delta,1.0,PRIMARY,NO,Cc1cc(SCc2sc(nc2C)c3ccc(c(F)c3)C(F)(F)F)ccc1OCC(=O)O,4,107,"InChI=1S/C21H17F4NO3S2/c1-11-7-14(4-6-17(11)29-9-19(27)28)30-10-18-12(2)26-20(31-18)13-3-5-15(16(22)8-13)21(23,24)25/h3-8H,9-10H2,1-2H3,(H,27,28)",HWVNEWGKWRGSRK-UHFFFAOYSA-N,"c(""Peroxisome proliferator-activated receptor alpha"", ""Peroxisome proliferator-activated receptor gamma"", ""Peroxisome proliferator-activated receptor delta"", ""Endoplasmic reticulum-associated amyloid beta-peptide-binding protein"", ""Microtubule-associated protein tau"", ""Aldehyde dehydrogenase 1A1"", ""Arachidonate 15-lipoxygenase"", ""Menin/Histone-lysine N-methyltransferase MLL"", ""15-hydroxyprostaglandin dehydrogenase [NAD+]"", ""Beta-glucocerebrosidase"", ""Histone acetyltransferase GCN5"", ""Arachidonate 15-lipoxygenase, type II"", ""Vitamin D receptor"", ""Retinoid X receptor alpha"", ""Estrogen receptor alpha"", ""Glucocorticoid receptor"", ""Thyroid hormone receptor beta-1"", ""DNA polymerase kappa"", ""Nuclear factor erythroid 2-related factor 2"", ""Cellular tumor antigen p53"", ""Unchecked"", ""Androgen Receptor"", ""Heat shock protein beta-1"", ""Nuclear factor NF-kappa-B p105 subunit"", ""Proto-oncogene c-JUN"")",5467,PPARD,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1430728 Metabolism R-HSA-162582 Signal Transduction R-HSA-200425 Import of palmitoyl-CoA into the mitochondrial matrix R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-212436 Generic Transcription Pathway R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-535734 Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-5362517 Signaling by Retinoic Acid R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-70268 Pyruvate metabolism R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-74160 Gene Expression",nuclear chromatin GO:0000790 ISS nucleus GO:0005634 11551955 NAS nucleoplasm GO:0005654 TAS,"GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS 15793256 GO:0006006 glucose metabolic process NAS GO:0006029 proteoglycan metabolic process IEA 1333051 GO:0006091 generation of precursor metabolites and energy TAS 1333051 GO:0006357 regulation of transcription from RNA polymerase II promoter TAS GO:0006367 transcription initiation from RNA polymerase II promoter TAS GO:0006629 lipid metabolic process ISS GO:0006635 fatty acid beta-oxidation ISS 15192438 15803109 GO:0006635 fatty acid beta-oxidation TAS GO:0006776 vitamin A metabolic process IEA 12909723 GO:0006915 apoptotic process IMP GO:0007507 heart development IEA 11551955 GO:0007566 embryo implantation TAS 15192438 GO:0008203 cholesterol metabolic process TAS GO:0008283 cell proliferation ISS 11847022 GO:0008283 cell proliferation TAS GO:0008366 axon ensheathment ISS GO:0008654 phospholipid biosynthetic process IEA 15192438 GO:0009062 fatty acid catabolic process TAS GO:0009299 mRNA transcription IEA GO:0009749 response to glucose IEA GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA GO:0014823 response to activity IEA GO:0014842 regulation of skeletal muscle satellite cell proliferation IEA GO:0014912 negative regulation of smooth muscle cell migration IEA 15793256 GO:0015758 glucose transport NAS GO:0015908 fatty acid transport ISS GO:0030154 cell differentiation IEA GO:0030308 negative regulation of cell growth IEA GO:0030522 intracellular receptor signaling pathway IEA GO:0031589 cell-substrate adhesion IEA GO:0032024 positive regulation of insulin secretion IEA GO:0032966 negative regulation of collagen biosynthetic process IEA GO:0033189 response to vitamin A IEA GO:0042060 wound healing IEA GO:0043066 negative regulation of apoptotic process IEA GO:0043401 steroid hormone mediated signaling pathway IEA GO:0043415 positive regulation of skeletal muscle tissue regeneration IEA GO:0043616 keratinocyte proliferation IEA 10991946 GO:0045600 positive regulation of fat cell differentiation NAS GO:0045662 negative regulation of myoblast differentiation IEA GO:0045684 positive regulation of epidermis development IEA GO:0045892 negative regulation of transcription, DNA-templated ISS 12955147 GO:0045893 positive regulation of transcription, DNA-templated IDA GO:0045909 positive regulation of vasodilation IEA 11551955 GO:0046697 decidualization TAS GO:0048662 negative regulation of smooth muscle cell proliferation IEA GO:0050680 negative regulation of epithelial cell proliferation IEA GO:0050728 negative regulation of inflammatory response IEA GO:0051546 keratinocyte migration IEA GO:0060612 adipose tissue development IEA GO:0071222 cellular response to lipopolysaccharide IEA GO:0071456 cellular response to hypoxia IEA 11551955 GO:0097190 apoptotic signaling pathway IMP GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter ISS GO:2000288 positive regulation of myoblast proliferation IEA","transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding ISS GO:0001227 DNA binding ISS GO:0003677 transcription factor activity, sequence-specific DNA binding IDA 12955147 GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 11551955 GO:0003700 steroid hormone receptor activity IEA GO:0003707 transcription coactivator activity IEA GO:0003713 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IDA 12955147 GO:0004879 protein binding IPI 23455924 GO:0005515 drug binding IDA 9113987 10198642 GO:0008144 zinc ion binding IEA GO:0008270 lipid binding IDA 12955147 GO:0008289 sequence-specific DNA binding IEA GO:0043565 protein heterodimerization activity IEA GO:0046982 NF-kappaB binding IEA GO:0051059 linoleic acid binding IDA 10198642 GO:0070539",PPAR signaling pathway - Homo sapiens (human) hsa03320 Wnt signaling pathway - Homo sapiens (human) hsa04310 Pathways in cancer - Homo sapiens (human) hsa05200 Acute myeloid leukemia - Homo sapiens (human) hsa05221,CHEMBL CHEMBL495990,Q03181,Peroxisome proliferator-activated receptor delta,1.0,ORTHOGONAL,YES,OC(=O)COc1ccc(Sc2ccc(COc3ccc(cc3)C(F)(F)F)cc2OCC#C)c4CCCCc14,3,9,"InChI=1S/C29H25F3O5S/c1-2-15-35-25-16-19(17-36-21-10-8-20(9-11-21)29(30,31)32)7-13-27(25)38-26-14-12-24(37-18-28(33)34)22-5-3-4-6-23(22)26/h1,7-14,16H,3-6,15,17-18H2,(H,33,34)",ZCORSQTXEMWYOI-UHFFFAOYSA-N,"c(""Peroxisome proliferator-activated receptor alpha"", ""Peroxisome proliferator-activated receptor delta"", ""Peroxisome proliferator-activated receptor gamma"")",5467,PPARD,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1430728 Metabolism R-HSA-162582 Signal Transduction R-HSA-200425 Import of palmitoyl-CoA into the mitochondrial matrix R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-212436 Generic Transcription Pathway R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-535734 Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-5362517 Signaling by Retinoic Acid R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-70268 Pyruvate metabolism R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-74160 Gene Expression",nuclear chromatin GO:0000790 ISS nucleus GO:0005634 11551955 NAS nucleoplasm GO:0005654 TAS,"GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS 15793256 GO:0006006 glucose metabolic process NAS GO:0006029 proteoglycan metabolic process IEA 1333051 GO:0006091 generation of precursor metabolites and energy TAS 1333051 GO:0006357 regulation of transcription from RNA polymerase II promoter TAS GO:0006367 transcription initiation from RNA polymerase II promoter TAS GO:0006629 lipid metabolic process ISS GO:0006635 fatty acid beta-oxidation ISS 15192438 15803109 GO:0006635 fatty acid beta-oxidation TAS GO:0006776 vitamin A metabolic process IEA 12909723 GO:0006915 apoptotic process IMP GO:0007507 heart development IEA 11551955 GO:0007566 embryo implantation TAS 15192438 GO:0008203 cholesterol metabolic process TAS GO:0008283 cell proliferation ISS 11847022 GO:0008283 cell proliferation TAS GO:0008366 axon ensheathment ISS GO:0008654 phospholipid biosynthetic process IEA 15192438 GO:0009062 fatty acid catabolic process TAS GO:0009299 mRNA transcription IEA GO:0009749 response to glucose IEA GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA GO:0014823 response to activity IEA GO:0014842 regulation of skeletal muscle satellite cell proliferation IEA GO:0014912 negative regulation of smooth muscle cell migration IEA 15793256 GO:0015758 glucose transport NAS GO:0015908 fatty acid transport ISS GO:0030154 cell differentiation IEA GO:0030308 negative regulation of cell growth IEA GO:0030522 intracellular receptor signaling pathway IEA GO:0031589 cell-substrate adhesion IEA GO:0032024 positive regulation of insulin secretion IEA GO:0032966 negative regulation of collagen biosynthetic process IEA GO:0033189 response to vitamin A IEA GO:0042060 wound healing IEA GO:0043066 negative regulation of apoptotic process IEA GO:0043401 steroid hormone mediated signaling pathway IEA GO:0043415 positive regulation of skeletal muscle tissue regeneration IEA GO:0043616 keratinocyte proliferation IEA 10991946 GO:0045600 positive regulation of fat cell differentiation NAS GO:0045662 negative regulation of myoblast differentiation IEA GO:0045684 positive regulation of epidermis development IEA GO:0045892 negative regulation of transcription, DNA-templated ISS 12955147 GO:0045893 positive regulation of transcription, DNA-templated IDA GO:0045909 positive regulation of vasodilation IEA 11551955 GO:0046697 decidualization TAS GO:0048662 negative regulation of smooth muscle cell proliferation IEA GO:0050680 negative regulation of epithelial cell proliferation IEA GO:0050728 negative regulation of inflammatory response IEA GO:0051546 keratinocyte migration IEA GO:0060612 adipose tissue development IEA GO:0071222 cellular response to lipopolysaccharide IEA GO:0071456 cellular response to hypoxia IEA 11551955 GO:0097190 apoptotic signaling pathway IMP GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter ISS GO:2000288 positive regulation of myoblast proliferation IEA","transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding ISS GO:0001227 DNA binding ISS GO:0003677 transcription factor activity, sequence-specific DNA binding IDA 12955147 GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 11551955 GO:0003700 steroid hormone receptor activity IEA GO:0003707 transcription coactivator activity IEA GO:0003713 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IDA 12955147 GO:0004879 protein binding IPI 23455924 GO:0005515 drug binding IDA 9113987 10198642 GO:0008144 zinc ion binding IEA GO:0008270 lipid binding IDA 12955147 GO:0008289 sequence-specific DNA binding IEA GO:0043565 protein heterodimerization activity IEA GO:0046982 NF-kappaB binding IEA GO:0051059 linoleic acid binding IDA 10198642 GO:0070539",PPAR signaling pathway - Homo sapiens (human) hsa03320 Wnt signaling pathway - Homo sapiens (human) hsa04310 Pathways in cancer - Homo sapiens (human) hsa05200 Acute myeloid leukemia - Homo sapiens (human) hsa05221,CHEMBL CHEMBL38943,Q03181,Peroxisome proliferator-activated receptor delta,1.0,PRIMARY,YES,Cc1cc(SCc2sc(nc2C)c3ccc(cc3)C(F)(F)F)ccc1OCC(=O)O,3,118,"InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27)",YDBLKRPLXZNVNB-UHFFFAOYSA-N,"c(""Peroxisome proliferator-activated receptor alpha"", ""Peroxisome proliferator-activated receptor gamma"", ""Peroxisome proliferator-activated receptor delta"", ""Unchecked"", ""PPAR delta/gamma"")",5467,PPARD,"R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1430728 Metabolism R-HSA-162582 Signal Transduction R-HSA-200425 Import of palmitoyl-CoA into the mitochondrial matrix R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-212436 Generic Transcription Pathway R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-535734 Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-5362517 Signaling by Retinoic Acid R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-70268 Pyruvate metabolism R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-74160 Gene Expression",nuclear chromatin GO:0000790 ISS nucleus GO:0005634 11551955 NAS nucleoplasm GO:0005654 TAS,"GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS 15793256 GO:0006006 glucose metabolic process NAS GO:0006029 proteoglycan metabolic process IEA 1333051 GO:0006091 generation of precursor metabolites and energy TAS 1333051 GO:0006357 regulation of transcription from RNA polymerase II promoter TAS GO:0006367 transcription initiation from RNA polymerase II promoter TAS GO:0006629 lipid metabolic process ISS GO:0006635 fatty acid beta-oxidation ISS 15192438 15803109 GO:0006635 fatty acid beta-oxidation TAS GO:0006776 vitamin A metabolic process IEA 12909723 GO:0006915 apoptotic process IMP GO:0007507 heart development IEA 11551955 GO:0007566 embryo implantation TAS 15192438 GO:0008203 cholesterol metabolic process TAS GO:0008283 cell proliferation ISS 11847022 GO:0008283 cell proliferation TAS GO:0008366 axon ensheathment ISS GO:0008654 phospholipid biosynthetic process IEA 15192438 GO:0009062 fatty acid catabolic process TAS GO:0009299 mRNA transcription IEA GO:0009749 response to glucose IEA GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA GO:0014823 response to activity IEA GO:0014842 regulation of skeletal muscle satellite cell proliferation IEA GO:0014912 negative regulation of smooth muscle cell migration IEA 15793256 GO:0015758 glucose transport NAS GO:0015908 fatty acid transport ISS GO:0030154 cell differentiation IEA GO:0030308 negative regulation of cell growth IEA GO:0030522 intracellular receptor signaling pathway IEA GO:0031589 cell-substrate adhesion IEA GO:0032024 positive regulation of insulin secretion IEA GO:0032966 negative regulation of collagen biosynthetic process IEA GO:0033189 response to vitamin A IEA GO:0042060 wound healing IEA GO:0043066 negative regulation of apoptotic process IEA GO:0043401 steroid hormone mediated signaling pathway IEA GO:0043415 positive regulation of skeletal muscle tissue regeneration IEA GO:0043616 keratinocyte proliferation IEA 10991946 GO:0045600 positive regulation of fat cell differentiation NAS GO:0045662 negative regulation of myoblast differentiation IEA GO:0045684 positive regulation of epidermis development IEA GO:0045892 negative regulation of transcription, DNA-templated ISS 12955147 GO:0045893 positive regulation of transcription, DNA-templated IDA GO:0045909 positive regulation of vasodilation IEA 11551955 GO:0046697 decidualization TAS GO:0048662 negative regulation of smooth muscle cell proliferation IEA GO:0050680 negative regulation of epithelial cell proliferation IEA GO:0050728 negative regulation of inflammatory response IEA GO:0051546 keratinocyte migration IEA GO:0060612 adipose tissue development IEA GO:0071222 cellular response to lipopolysaccharide IEA GO:0071456 cellular response to hypoxia IEA 11551955 GO:0097190 apoptotic signaling pathway IMP GO:1902894 negative regulation of pri-miRNA transcription from RNA polymerase II promoter ISS GO:2000288 positive regulation of myoblast proliferation IEA","transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding ISS GO:0001227 DNA binding ISS GO:0003677 transcription factor activity, sequence-specific DNA binding IDA 12955147 GO:0003700 transcription factor activity, sequence-specific DNA binding NAS 11551955 GO:0003700 steroid hormone receptor activity IEA GO:0003707 transcription coactivator activity IEA GO:0003713 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IDA 12955147 GO:0004879 protein binding IPI 23455924 GO:0005515 drug binding IDA 9113987 10198642 GO:0008144 zinc ion binding IEA GO:0008270 lipid binding IDA 12955147 GO:0008289 sequence-specific DNA binding IEA GO:0043565 protein heterodimerization activity IEA GO:0046982 NF-kappaB binding IEA GO:0051059 linoleic acid binding IDA 10198642 GO:0070539",PPAR signaling pathway - Homo sapiens (human) hsa03320 Wnt signaling pathway - Homo sapiens (human) hsa04310 Pathways in cancer - Homo sapiens (human) hsa05200 Acute myeloid leukemia - Homo sapiens (human) hsa05221,CHEMBL CHEMBL434063,P37231,Peroxisome proliferator-activated receptor gamma,1.0,PRIMARY,NO,CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c3ccccc3)C(=O)O)cc1)c4ccccn4,17,58,"InChI=1S/C30H29N3O4/c1-33(28-13-7-8-18-31-28)19-20-37-24-16-14-22(15-17-24)21-27(30(35)36)32-26-12-6-5-11-25(26)29(34)23-9-3-2-4-10-23/h2-18,27,32H,19-21H2,1H3,(H,35,36)/t27-/m0/s1",QTQMRBZOBKYXCG-MHZLTWQESA-N,"c(""Peroxisome proliferator-activated receptor gamma"", ""Peroxisome proliferator-activated receptor alpha"", ""Peroxisome proliferator-activated receptor delta"", ""PC-3"", ""Menin/Histone-lysine N-methyltransferase MLL"", ""Prelamin-A/C"", ""Nuclear factor NF-kappa-B p105 subunit"", ""Endoplasmic reticulum-associated amyloid beta-peptide-binding protein"", ""Unchecked"", ""Thyroid stimulating hormone receptor"", ""Tyrosyl-DNA phosphodiesterase 1"", ""Microtubule-associated protein tau"", ""Hypoxia-inducible factor 1 alpha"", ""Bloom syndrome protein"", ""Geminin"", ""Histone acetyltransferase GCN5"", ""M-phase phosphoprotein 8"", ""Histone-lysine N-methyltransferase, H3 lysine-9 specific 3"", ""Vitamin D receptor"", ""Regulator of G-protein signaling 4"", ""Ubiquitin carboxyl-terminal hydrolase 1"", ""Adenosine A1 receptor"", ""Adenosine A2a receptor"", ""Adenosine A3 receptor"", ""Alpha-2b adrenergic receptor"", ""Beta-3 adrenergic receptor"", ""Norepinephrine transporter"", ""Dopamine transporter"", ""Cysteinyl leukotriene receptor 1"", ""Delta opioid receptor"", ""Epidermal growth factor receptor erbB1"", ""Neurokinin 2 receptor"", ""Thromboxane-A synthase"", ""DNA-(apurinic or apyrimidinic site) lyase"")",5468,PPARG,Developmental Biology R-HSA-1266738 Generic Transcription Pathway R-HSA-212436 Transcriptional regulation of white adipocyte differentiation R-HSA-381340 Nuclear Receptor transcription pathway R-HSA-383280 Gene Expression R-HSA-74160,nucleus 9568716 GO:0005634 IDA nucleoplasm GO:0005654 TAS Golgi apparatus GO:0005794 IDA cytosol GO:0005829 ISS intracellular membrane-bounded organelle GO:0043231 IDA perinuclear region of cytoplasm GO:0048471 IEA RNA polymerase II transcription factor complex 9568716 GO:0090575 IDA,"negative regulation of transcription from RNA polymerase II promoter IDA 12700342 GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS GO:0000122 placenta development ISS GO:0001890 negative regulation of acute inflammatory response IEA GO:0002674 transcription initiation from RNA polymerase II promoter TAS GO:0006367 lipid metabolic process TAS 9568716 GO:0006629 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 18293083 GO:0006919 signal transduction IDA 9568716 GO:0007165 G-protein coupled receptor signaling pathway IEA GO:0007186 heart development IEA GO:0007507 response to nutrient TAS 10973253 GO:0007584 regulation of blood pressure IMP 10622252 GO:0008217 response to cold IEA GO:0009409 response to mechanical stimulus IEA GO:0009612 negative regulation of macrophage derived foam cell differentiation IC 12700342 GO:0010745 negative regulation of macrophage derived foam cell differentiation IDA 19114110 GO:0010745 negative regulation of receptor biosynthetic process IDA 12700342 GO:0010871 negative regulation of cholesterol storage IDA 19114110 GO:0010887 negative regulation of sequestering of triglyceride IDA 12700342 GO:0010891 long-chain fatty acid transport ISS GO:0015909 fatty acid oxidation IEA GO:0019395 monocyte differentiation IDA 9568716 GO:0030224 negative regulation of cell growth IEA GO:0030308 epithelial cell differentiation ISS GO:0030855 response to caffeine IEA GO:0031000 organ regeneration IEA GO:0031100 response to retinoic acid IDA 16239304 GO:0032526 cellular response to insulin stimulus IMP 10622252 GO:0032869 negative regulation of collagen biosynthetic process IEA GO:0032966 response to vitamin A IEA GO:0033189 response to lipid ISS 9568715 GO:0033993 peroxisome proliferator activated receptor signaling pathway IMP 20622039 GO:0035357 response to immobilization stress IEA GO:0035902 response to diuretic IEA GO:0036270 glucose homeostasis IMP 10622252 GO:0042593 response to starvation IEA GO:0042594 regulation of circadian rhythm ISS GO:0042752 lipoprotein transport IDA 9568716 GO:0042953 steroid hormone mediated signaling pathway IEA GO:0043401 response to estrogen IEA GO:0043627 innate immune response TAS 17145956 GO:0045087 cell fate commitment ISS GO:0045165 positive regulation of fat cell differentiation ISS GO:0045600 low-density lipoprotein particle receptor biosynthetic process IDA 9568716 GO:0045713 negative regulation of transcription, DNA-templated ISS GO:0045892 positive regulation of transcription, DNA-templated ISS GO:0045893 positive regulation of transcription from RNA polymerase II promoter IDA 9568715 12700342 16239304 17611579 GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP 20622039 GO:0045944 positive regulation of fatty acid oxidation IEA GO:0046321 cell maturation IDA 9568716 GO:0048469 rhythmic process IEA GO:0048511 negative regulation of smooth muscle cell proliferation IDA 20622039 GO:0048662 positive regulation of oligodendrocyte differentiation IEA GO:0048714 white fat cell differentiation ISS GO:0050872 white fat cell differentiation TAS 12588810 GO:0050872 positive regulation of sequence-specific DNA binding transcription factor activity IDA 18293083 GO:0051091 negative regulation of telomerase activity IEA GO:0051974 lipid homeostasis TAS 9113987 GO:0055088 response to low-density lipoprotein particle IDA 9568716 GO:0055098 positive regulation of phagocytosis, engulfment IEA GO:0060100 negative regulation of interferon-gamma-mediated signaling pathway IMP 21268089 GO:0060336 regulation of cholesterol transporter activity IC 17611579 GO:0060694 regulation of transcription involved in cell fate commitment ISS GO:0060850 cellular response to retinoic acid IEA GO:0071300 cellular response to vitamin E IEA GO:0071306 cellular response to prostaglandin E stimulus IEA GO:0071380 cellular response to hyperoxia IEA GO:0071455 response to metformin IEA GO:1901558 negative regulation of pancreatic stellate cell proliferation IEA GO:2000230","GO:0001046 core promoter sequence-specific DNA binding ISS GO:0003677 DNA binding 16239304 IDA GO:0003677 DNA binding ISS GO:0003682 chromatin binding ISS GO:0003700 transcription factor activity, sequence-specific DNA binding 9568715 IDA GO:0003700 transcription factor activity, sequence-specific DNA binding ISS GO:0003707 steroid hormone receptor activity IEA GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding 10622252 IDA GO:0004955 prostaglandin receptor activity 9568715 TAS GO:0005515 protein binding 10428834 12040021 14701856 16239304 17500595 20195357 22351778 IPI GO:0008144 drug binding 9113987 10622252 IDA GO:0008270 zinc ion binding IEA GO:0019899 enzyme binding 12039952 IPI GO:0019903 protein phosphatase binding IEA GO:0030331 estrogen receptor binding IEA GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity 16239304 IDA GO:0033613 activating transcription factor binding 10622252 IDA GO:0042802 identical protein binding 25609649 IPI GO:0043565 sequence-specific DNA binding contributes_to 9568716 IDA GO:0044212 transcription regulatory region DNA binding 18293083 IDA GO:0044212 transcription regulatory region DNA binding ISS GO:0046965 retinoid X receptor binding 9568715 IDA GO:0050544 arachidonic acid binding 9568715 ISS GO:0051393 alpha-actinin binding 22351778 IPI","hsa03320 PPAR signaling pathway - Homo sapiens (human) hsa04152 AMPK signaling pathway - Homo sapiens (human) hsa04380 Osteoclast differentiation - Homo sapiens (human) hsa05016 Huntington,s disease - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) hsa05216 Thyroid cancer - Homo sapiens (human)",CHEMBL CHEMBL461571,P37231,Peroxisome proliferator-activated receptor gamma,1.0,PRIMARY,YES,C[C@@H](Oc1cccc(Cn2c(C)c(C(=O)c3ccc(Cl)cc3)c4ccc(OC(F)(F)F)cc24)c1)C(=O)O,27,40,"InChI=1S/C27H21ClF3NO5/c1-15-24(25(33)18-6-8-19(28)9-7-18)22-11-10-21(37-27(29,30)31)13-23(22)32(15)14-17-4-3-5-20(12-17)36-16(2)26(34)35/h3-13,16H,14H2,1-2H3,(H,34,35)/t16-/m1/s1",DHUATBAZHILHIC-MRXNPFEDSA-N,"c(""Arachidonate 5-lipoxygenase"", ""Unchecked"", ""Epidermal growth factor receptor erbB1"", ""Prostanoid DP receptor"", ""Prostanoid EP3 receptor"", ""Prostanoid EP4 receptor"", ""Prostanoid FP receptor"", ""Prostanoid IP receptor"", ""Alpha-2a adrenergic receptor"", ""Alpha-2b adrenergic receptor"", ""Beta-1 adrenergic receptor"", ""Beta-3 adrenergic receptor"", ""Norepinephrine transporter"", ""Dopamine D1 receptor"", ""Dopamine D2 receptor"", ""Dopamine D3 receptor"", ""Dopamine transporter"", ""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M4"", ""Delta opioid receptor"", ""Kappa opioid receptor"", ""Mu opioid receptor"", ""Serotonin 2b (5-HT2b) receptor"", ""Serotonin transporter"", ""Neurokinin 2 receptor"", ""Thromboxane A2 receptor"", ""Peroxisome proliferator-activated receptor gamma"", ""Peroxisome proliferator-activated receptor alpha"")",5468,PPARG,Developmental Biology R-HSA-1266738 Generic Transcription Pathway R-HSA-212436 Transcriptional regulation of white adipocyte differentiation R-HSA-381340 Nuclear Receptor transcription pathway R-HSA-383280 Gene Expression R-HSA-74160,nucleus 9568716 GO:0005634 IDA nucleoplasm GO:0005654 TAS Golgi apparatus GO:0005794 IDA cytosol GO:0005829 ISS intracellular membrane-bounded organelle GO:0043231 IDA perinuclear region of cytoplasm GO:0048471 IEA RNA polymerase II transcription factor complex 9568716 GO:0090575 IDA,"negative regulation of transcription from RNA polymerase II promoter IDA 12700342 GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS GO:0000122 placenta development ISS GO:0001890 negative regulation of acute inflammatory response IEA GO:0002674 transcription initiation from RNA polymerase II promoter TAS GO:0006367 lipid metabolic process TAS 9568716 GO:0006629 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA 18293083 GO:0006919 signal transduction IDA 9568716 GO:0007165 G-protein coupled receptor signaling pathway IEA GO:0007186 heart development IEA GO:0007507 response to nutrient TAS 10973253 GO:0007584 regulation of blood pressure IMP 10622252 GO:0008217 response to cold IEA GO:0009409 response to mechanical stimulus IEA GO:0009612 negative regulation of macrophage derived foam cell differentiation IC 12700342 GO:0010745 negative regulation of macrophage derived foam cell differentiation IDA 19114110 GO:0010745 negative regulation of receptor biosynthetic process IDA 12700342 GO:0010871 negative regulation of cholesterol storage IDA 19114110 GO:0010887 negative regulation of sequestering of triglyceride IDA 12700342 GO:0010891 long-chain fatty acid transport ISS GO:0015909 fatty acid oxidation IEA GO:0019395 monocyte differentiation IDA 9568716 GO:0030224 negative regulation of cell growth IEA GO:0030308 epithelial cell differentiation ISS GO:0030855 response to caffeine IEA GO:0031000 organ regeneration IEA GO:0031100 response to retinoic acid IDA 16239304 GO:0032526 cellular response to insulin stimulus IMP 10622252 GO:0032869 negative regulation of collagen biosynthetic process IEA GO:0032966 response to vitamin A IEA GO:0033189 response to lipid ISS 9568715 GO:0033993 peroxisome proliferator activated receptor signaling pathway IMP 20622039 GO:0035357 response to immobilization stress IEA GO:0035902 response to diuretic IEA GO:0036270 glucose homeostasis IMP 10622252 GO:0042593 response to starvation IEA GO:0042594 regulation of circadian rhythm ISS GO:0042752 lipoprotein transport IDA 9568716 GO:0042953 steroid hormone mediated signaling pathway IEA GO:0043401 response to estrogen IEA GO:0043627 innate immune response TAS 17145956 GO:0045087 cell fate commitment ISS GO:0045165 positive regulation of fat cell differentiation ISS GO:0045600 low-density lipoprotein particle receptor biosynthetic process IDA 9568716 GO:0045713 negative regulation of transcription, DNA-templated ISS GO:0045892 positive regulation of transcription, DNA-templated ISS GO:0045893 positive regulation of transcription from RNA polymerase II promoter IDA 9568715 12700342 16239304 17611579 GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP 20622039 GO:0045944 positive regulation of fatty acid oxidation IEA GO:0046321 cell maturation IDA 9568716 GO:0048469 rhythmic process IEA GO:0048511 negative regulation of smooth muscle cell proliferation IDA 20622039 GO:0048662 positive regulation of oligodendrocyte differentiation IEA GO:0048714 white fat cell differentiation ISS GO:0050872 white fat cell differentiation TAS 12588810 GO:0050872 positive regulation of sequence-specific DNA binding transcription factor activity IDA 18293083 GO:0051091 negative regulation of telomerase activity IEA GO:0051974 lipid homeostasis TAS 9113987 GO:0055088 response to low-density lipoprotein particle IDA 9568716 GO:0055098 positive regulation of phagocytosis, engulfment IEA GO:0060100 negative regulation of interferon-gamma-mediated signaling pathway IMP 21268089 GO:0060336 regulation of cholesterol transporter activity IC 17611579 GO:0060694 regulation of transcription involved in cell fate commitment ISS GO:0060850 cellular response to retinoic acid IEA GO:0071300 cellular response to vitamin E IEA GO:0071306 cellular response to prostaglandin E stimulus IEA GO:0071380 cellular response to hyperoxia IEA GO:0071455 response to metformin IEA GO:1901558 negative regulation of pancreatic stellate cell proliferation IEA GO:2000230","GO:0001046 core promoter sequence-specific DNA binding ISS GO:0003677 DNA binding 16239304 IDA GO:0003677 DNA binding ISS GO:0003682 chromatin binding ISS GO:0003700 transcription factor activity, sequence-specific DNA binding 9568715 IDA GO:0003700 transcription factor activity, sequence-specific DNA binding ISS GO:0003707 steroid hormone receptor activity IEA GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding 10622252 IDA GO:0004955 prostaglandin receptor activity 9568715 TAS GO:0005515 protein binding 10428834 12040021 14701856 16239304 17500595 20195357 22351778 IPI GO:0008144 drug binding 9113987 10622252 IDA GO:0008270 zinc ion binding IEA GO:0019899 enzyme binding 12039952 IPI GO:0019903 protein phosphatase binding IEA GO:0030331 estrogen receptor binding IEA GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity 16239304 IDA GO:0033613 activating transcription factor binding 10622252 IDA GO:0042802 identical protein binding 25609649 IPI GO:0043565 sequence-specific DNA binding contributes_to 9568716 IDA GO:0044212 transcription regulatory region DNA binding 18293083 IDA GO:0044212 transcription regulatory region DNA binding ISS GO:0046965 retinoid X receptor binding 9568715 IDA GO:0050544 arachidonic acid binding 9568715 ISS GO:0051393 alpha-actinin binding 22351778 IPI","hsa03320 PPAR signaling pathway - Homo sapiens (human) hsa04152 AMPK signaling pathway - Homo sapiens (human) hsa04380 Osteoclast differentiation - Homo sapiens (human) hsa05016 Huntington,s disease - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) hsa05216 Thyroid cancer - Homo sapiens (human)",CHEMBL CHEMBL3582149,P08183,P-glycoprotein 1,1.0,ORTHOGONAL,NO,COc1cc(OC)c2C[C@@H](OC(=O)\C=C\c3cc(OC)c(OC)c(OC)c3)[C@H](Oc2c1)c4cc(OC)c(OC)c(OC)c4,3,13,"InChI=1S/C32H36O11/c1-34-20-15-22(35-2)21-17-28(42-29(33)10-9-18-11-24(36-3)31(40-7)25(12-18)37-4)30(43-23(21)16-20)19-13-26(38-5)32(41-8)27(14-19)39-6/h9-16,28,30H,17H2,1-8H3/b10-9+/t28-,30-/m1/s1",NECCTVFNAYKBCX-JPYFANRKSA-N,"c(""Unchecked"", ""P-glycoprotein 1"", ""Multidrug resistance-associated protein 1"", ""ATP-binding cassette sub-family G member 2"")",5243,MDR1,Metabolism R-HSA-1430728 Abacavir transmembrane transport R-HSA-2161517 Abacavir transport and metabolism R-HSA-2161522 Transmembrane transport of small molecules R-HSA-382551 ABC-family proteins mediated transport R-HSA-382556,GO:0005886 plasma membrane TAS 19384922 GO:0009986 cell surface IDA 3022150 GO:0016020 membrane TAS GO:0016021 integral component of membrane IEA 19056867 23376485 23533145 GO:0070062 extracellular exosome IDA,"G2/M transition of mitotic cell cycle GO:0000086 IDA 19384922 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent GO:0002481 IBA antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent GO:0002485 IBA antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent GO:0002489 IBA positive regulation of antigen processing and presentation of peptide antigen via MHC class I GO:0002591 IBA transport GO:0006810 TAS 3022150 drug transmembrane transport GO:0006855 IEA response to drug GO:0042493 TAS 3022150 xenobiotic transport GO:0042908 IEA transmembrane transport GO:0055085 TAS stem cell proliferation GO:0072089 IMP 19384922","transporter activity GO:0005215 TAS 3022150 protein binding GO:0005515 IPI 17088979 20711237 ATP binding GO:0005524 IEA xenobiotic-transporting ATPase activity GO:0008559 TAS ATPase activity, coupled to transmembrane movement of substances GO:0042626 TAS 3022150",ABC transporters - Homo sapiens (human) hsa02010 Bile secretion - Homo sapiens (human) hsa04976 MicroRNAs in cancer - Homo sapiens (human) hsa05206,CHEMBL CHEMBL3582155,P08183,P-glycoprotein 1,1.0,PRIMARY,NO,COc1cc(OC)c2C[C@@H](OC(=O)c3ccc(F)c(NC(=O)c4ccc(OC)c(OC)c4)c3)[C@H](Oc2c1)c5cc(OC)c(OC)c(OC)c5,3,13,"InChI=1S/C36H36FNO11/c1-41-22-16-27(43-3)23-18-32(33(48-28(23)17-22)21-14-30(45-5)34(47-7)31(15-21)46-6)49-36(40)20-8-10-24(37)25(12-20)38-35(39)19-9-11-26(42-2)29(13-19)44-4/h8-17,32-33H,18H2,1-7H3,(H,38,39)/t32-,33-/m1/s1",XPNBVAOZAHYCST-CZNDPXEESA-N,"c(""Unchecked"", ""P-glycoprotein 1"", ""Multidrug resistance-associated protein 1"", ""ATP-binding cassette sub-family G member 2"")",5243,MDR1,Metabolism R-HSA-1430728 Abacavir transmembrane transport R-HSA-2161517 Abacavir transport and metabolism R-HSA-2161522 Transmembrane transport of small molecules R-HSA-382551 ABC-family proteins mediated transport R-HSA-382556,GO:0005886 plasma membrane TAS 19384922 GO:0009986 cell surface IDA 3022150 GO:0016020 membrane TAS GO:0016021 integral component of membrane IEA 19056867 23376485 23533145 GO:0070062 extracellular exosome IDA,"G2/M transition of mitotic cell cycle GO:0000086 IDA 19384922 antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent GO:0002481 IBA antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent GO:0002485 IBA antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent GO:0002489 IBA positive regulation of antigen processing and presentation of peptide antigen via MHC class I GO:0002591 IBA transport GO:0006810 TAS 3022150 drug transmembrane transport GO:0006855 IEA response to drug GO:0042493 TAS 3022150 xenobiotic transport GO:0042908 IEA transmembrane transport GO:0055085 TAS stem cell proliferation GO:0072089 IMP 19384922","transporter activity GO:0005215 TAS 3022150 protein binding GO:0005515 IPI 17088979 20711237 ATP binding GO:0005524 IEA xenobiotic-transporting ATPase activity GO:0008559 TAS ATPase activity, coupled to transmembrane movement of substances GO:0042626 TAS 3022150",ABC transporters - Homo sapiens (human) hsa02010 Bile secretion - Homo sapiens (human) hsa04976 MicroRNAs in cancer - Homo sapiens (human) hsa05206,CHEMBL CHEMBL2381188,O00408,Phosphodiesterase 2A,1.0,PRIMARY,NO,Cc1nc(c2cnn(C)c2c3ccc(cc3)C(F)(F)F)c4c(ncnn14)N5CC(F)C5,11,12,"InChI=1S/C20H17F4N7/c1-11-28-16(18-19(25-10-27-31(11)18)30-8-14(21)9-30)15-7-26-29(2)17(15)12-3-5-13(6-4-12)20(22,23)24/h3-7,10,14H,8-9H2,1-2H3",NXNPDXUSIAPGFQ-UHFFFAOYSA-N,"c(""Phosphodiesterase 11A"", ""Phosphodiesterase 10A"", ""Phosphodiesterase 9A"", ""Phosphodiesterase 8B"", ""Phosphodiesterase 7B"", ""Phosphodiesterase 6A"", ""Phosphodiesterase 5A"", ""Phosphodiesterase 4D"", ""Phosphodiesterase 3A"", ""Phosphodiesterase 1B"", ""Phosphodiesterase 2A"")",5138,PDE2A,R-HSA-109582 Hemostasis R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-388396 GPCR downstream signaling R-HSA-392154 Nitric oxide stimulates guanylate cyclase R-HSA-418346 Platelet homeostasis R-HSA-418457 cGMP effects R-HSA-418555 G alpha (s) signalling events,nucleus IDA 10375378 GO:0005634 cytoplasm IDA 10375378 19506089 GO:0005737 mitochondrial matrix ISS GO:0005759 endoplasmic reticulum ISS GO:0005783 Golgi apparatus ISS GO:0005794 cytosol IDA 17329248 GO:0005829 cytosol TAS GO:0005829 plasma membrane IDA 19252089 GO:0005886 colocalizes_with plasma membrane IDA 17329248 GO:0005886 presynaptic membrane ISS GO:0042734 membrane raft IEA GO:0045121 perinuclear region of cytoplasm IDA 10375378 GO:0048471,"IDA 17329248 negative regulation of transcription from RNA polymerase II promoter GO:0000122 IDA 15938621 17704206 cAMP catabolic process GO:0006198 IMP 19252089 cAMP catabolic process GO:0006198 ISS GO:0006626 protein targeting to mitochondrion IDA 17329248 metabolic process GO:0008152 IMP 17704206 cAMP-mediated signaling GO:0019933 IMP 17704206 cGMP-mediated signaling GO:0019934 ISS GO:0030818 negative regulation of cAMP biosynthetic process IDA 17329248 negative regulation of protein import into nucleus, translocation GO:0033159 IMP 15938621 cellular response to drug GO:0035690 IDA 14687666 cellular response to macrophage colony-stimulating factor stimulus GO:0036006 IMP 17704206 negative regulation of vascular permeability GO:0043116 IMP 17704206 positive regulation of vascular permeability GO:0043117 IDA 15938621 19828435 cGMP catabolic process GO:0046069 ISS GO:0050729 positive regulation of inflammatory response ISS GO:0061028 establishment of endothelial barrier IEA GO:0070588 calcium ion transmembrane transport ISS GO:0071260 cellular response to mechanical stimulus IDA 17704206 19828435 cellular response to cGMP GO:0071321 IEP 17704206 cellular response to transforming growth factor beta stimulus GO:0071560","IDA 15938621 cyclic-nucleotide phosphodiesterase activity GO:0004112 TAS GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity IDA 17329248 19689430 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity GO:0004118 TAS 10375378 calcium channel activity GO:0005262 IPI 17329248 protein binding GO:0005515 IDA 15938621 drug binding GO:0008144 IPI 15938621 drug binding GO:0008144 IMP 15938621 cAMP binding GO:0030552 IDA 17329248 19689430 19828435 cGMP binding GO:0030553 IMP 15938621 cGMP binding GO:0030553 IPI 17329248 TPR domain binding GO:0030911 IPI 19828435 protein homodimerization activity GO:0042803 IEA GO:0046872 metal ion binding TAS GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity",Purine metabolism - Homo sapiens (human) hsa00230 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 Morphine addiction - Homo sapiens (human) hsa05032,CHEMBL CHEMBL498486,O76074,Phosphodiesterase 5A,1.0,PRIMARY,NO,COc1ccc(cc1)C2=C(OCCO)C(=O)c3c(O)cc(OCCO)c(CC=C(C)C)c3O2,2,8,"InChI=1S/C25H28O8/c1-15(2)4-9-18-20(31-12-10-26)14-19(28)21-22(29)25(32-13-11-27)23(33-24(18)21)16-5-7-17(30-3)8-6-16/h4-8,14,26-28H,9-13H2,1-3H3",WTJGVHRGWYENBZ-UHFFFAOYSA-N,"c(""Phosphodiesterase 5A"", ""Phosphodiesterase 6C"", ""Unchecked"", ""MCF7"", ""A549"")",8654,PDE5A,Hemostasis R-HSA-109582 Nitric oxide stimulates guanylate cyclase R-HSA-392154 Platelet homeostasis R-HSA-418346 cGMP effects R-HSA-418457,GO:0005575 cellular_component ND GO:0005829 cytosol TAS,IEA GO:0007165 signal transduction IEA GO:0010613 positive regulation of cardiac muscle hypertrophy IEA GO:0030823 regulation of cGMP metabolic process IEA GO:0042130 negative regulation of T cell proliferation IEA GO:0043406 positive regulation of MAP kinase activity 14687666 IDA GO:0046069 cGMP catabolic process IEA GO:0046069 cGMP catabolic process IEA GO:0055118 negative regulation of cardiac muscle contraction IEA GO:0055119 relaxation of cardiac muscle IEA GO:0060282 positive regulation of oocyte development,"9714779 NAS GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 15938621 TAS GO:0030553 cGMP binding IEA GO:0046872 metal ion binding TAS GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity",hsa00230 Purine metabolism - Homo sapiens (human) hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human),CHEMBL CHEMBL492572,Q13393,Phospholipase D1,1.0,PRIMARY,NO,C[C@@H](CN1CCC(CC1)N2C(=O)Nc3cc(Cl)ccc23)NC(=O)c4ccc5ccccc5c4,2,12,"InChI=1S/C26H27ClN4O2/c1-17(28-25(32)20-7-6-18-4-2-3-5-19(18)14-20)16-30-12-10-22(11-13-30)31-24-9-8-21(27)15-23(24)29-26(31)33/h2-9,14-15,17,22H,10-13,16H2,1H3,(H,28,32)(H,29,33)/t17-/m0/s1",DRIMIUYGTDAQOX-KRWDZBQOSA-N,"c(""Phospholipase D1"", ""Unchecked"", ""Phospholipase D2"")",5337,PLD1,R-HSA-1430728 Metabolism R-HSA-1483148 Synthesis of PG R-HSA-1483166 Synthesis of PA R-HSA-1483206 Glycerophospholipid biosynthesis R-HSA-1483257 Phospholipid metabolism R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029485 Role of phospholipids in phagocytosis R-HSA-556833 Metabolism of lipids and lipoproteins,Golgi membrane GO:0000139 IEA lysosomal membrane GO:0005765 IDA 17897319 endosome GO:0005768 IDA 14718562 endoplasmic reticulum membrane GO:0005789 TAS Golgi apparatus GO:0005794 IDA 14718562 membrane GO:0016020 IDA 19946888 apical plasma membrane GO:0016324 IDA 22797597 endocytic vesicle GO:0030139 IDA 22797597 late endosome membrane GO:0031902 IEA perinuclear region of cytoplasm GO:0048471 IEA,phosphatidic acid biosynthetic process GO:0006654 TAS chemotaxis GO:0006935 10848592 TAS small GTPase mediated signal transduction GO:0007264 8530346 TAS Ras protein signal transduction GO:0007265 10848592 TAS lipid catabolic process GO:0016042 IEA regulation of cell migration GO:0030334 IEA regulation of microvillus assembly GO:0032534 22797597 IMP inositol lipid-mediated signaling GO:0048017 IEA cell motility GO:0048870 IBA regulation of phagocytosis GO:0050764 IEA,phospholipase D activity GO:0004630 TAS protein binding GO:0005515 17853892 IPI phosphatidylinositol binding GO:0035091 IEA N-acylphosphatidylethanolamine-specific phospholipase D activity GO:0070290 IEA,Glycerophospholipid metabolism - Homo sapiens (human) hsa00564 Ether lipid metabolism - Homo sapiens (human) hsa00565 Ras signaling pathway - Homo sapiens (human) hsa04014 cAMP signaling pathway - Homo sapiens (human) hsa04024 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 Endocytosis - Homo sapiens (human) hsa04144 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04666 Glutamatergic synapse - Homo sapiens (human) hsa04724 GnRH signaling pathway - Homo sapiens (human) hsa04912 Pathways in cancer - Homo sapiens (human) hsa05200 Pancreatic cancer - Homo sapiens (human) hsa05212 Choline metabolism in cancer - Homo sapiens (human) hsa05231,CHEMBL CHEMBL1254577,O14939,Phospholipase D2,1.0,PRIMARY,NO,Fc1cccc(c1)N2CNC(=O)C23CCN(CCNC(=O)c4ccc5ccccc5c4)CC3,2,10,"InChI=1S/C26H27FN4O2/c27-22-6-3-7-23(17-22)31-18-29-25(33)26(31)10-13-30(14-11-26)15-12-28-24(32)21-9-8-19-4-1-2-5-20(19)16-21/h1-9,16-17H,10-15,18H2,(H,28,32)(H,29,33)",MSTXJJGAXXJCBY-UHFFFAOYSA-N,"c(""Phospholipase D1"", ""Phospholipase D2"", ""Unchecked"", ""Ataxin-2"", ""Glucagon-like peptide 1 receptor"", ""Isocitrate dehydrogenase [NADP] cytoplasmic"", ""Alpha-synuclein"")",5338,PLD2,R-HSA-1430728 Metabolism R-HSA-1483148 Synthesis of PG R-HSA-1483166 Synthesis of PA R-HSA-1483206 Glycerophospholipid biosynthesis R-HSA-1483257 Phospholipid metabolism R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029485 Role of phospholipids in phagocytosis R-HSA-556833 Metabolism of lipids and lipoproteins,TAS GO:0005789 endoplasmic reticulum membrane IBA GO:0005794 Golgi apparatus IEA GO:0005829 cytosol TAS GO:0005886 plasma membrane IEA GO:0098793 presynapse,phosphatidic acid biosynthetic process GO:0006654 TAS cytoskeleton organization 9395408 GO:0007010 TAS small GTPase mediated signal transduction 9582313 GO:0007264 TAS lipid catabolic process GO:0016042 IEA regulation of cell migration GO:0030334 IEA synaptic vesicle recycling 24252804 GO:0036465 TAS Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS inositol lipid-mediated signaling GO:0048017 IEA cell motility GO:0048870 IBA regulation of phagocytosis GO:0050764 IEA,phospholipase D activity GO:0004630 TAS protein binding 16407827 17276458 17853892 GO:0005515 IPI phosphatidylinositol binding GO:0035091 IEA N-acylphosphatidylethanolamine-specific phospholipase D activity GO:0070290 IEA,hsa00564 Glycerophospholipid metabolism - Homo sapiens (human) hsa00565 Ether lipid metabolism - Homo sapiens (human) hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04071 Sphingolipid signaling pathway - Homo sapiens (human) hsa04144 Endocytosis - Homo sapiens (human) hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04724 Glutamatergic synapse - Homo sapiens (human) hsa04912 GnRH signaling pathway - Homo sapiens (human) hsa05231 Choline metabolism in cancer - Homo sapiens (human),CHEMBL CHEMBL2087491,P42336,PI3-kinase p110-alpha subunit,1.0,PRIMARY,NO,CS(=O)(=O)N1CCN(Cc2nc3c(nc(cn3c2Br)c4cnc(N)nc4)N5CCOCC5)CC1,24,51,"InChI=1S/C20H26BrN9O3S/c1-34(31,32)29-4-2-27(3-5-29)12-16-17(21)30-13-15(14-10-23-20(22)24-11-14)25-18(19(30)26-16)28-6-8-33-9-7-28/h10-11,13H,2-9,12H2,1H3,(H2,22,23,24)",NSQMUBUWCVCQFY-UHFFFAOYSA-N,"c(""PI3-kinase p110-alpha subunit"", ""Serine/threonine-protein kinase mTOR"", ""Serine/threonine-protein kinase AKT"", ""NUAK family SNF1-like kinase 1"", ""Unchecked"", ""Casein kinase I alpha"", ""Dual-specificity tyrosine-phosphorylation regulated kinase 1A"", ""Epidermal growth factor receptor erbB1"", ""Focal adhesion kinase 1"", ""Fibroblast growth factor receptor 1"", ""Tyrosine-protein kinase receptor FLT3"", ""Insulin-like growth factor I receptor"", ""Inhibitor of nuclear factor kappa B kinase beta subunit"", ""Insulin receptor"", ""Tyrosine-protein kinase JAK2"", ""c-Jun N-terminal kinase 1"", ""Stem cell growth factor receptor"", ""Dual specificity mitogen-activated protein kinase kinase 1"", ""Hepatocyte growth factor receptor"", ""Serine/threonine-protein kinase MST1"", ""Serine/threonine-protein kinase PAK 1"", ""Serine/threonine-protein kinase PIM1"", ""Serine/threonine-protein kinase PIM2"", ""Ribosomal protein S6 kinase alpha 1"", ""Serine/threonine-protein kinase Sgk1"", ""PI3-kinase p110-alpha/p85-alpha"")",5290,PK3CA,"R-HSA-109582 Hemostasis R-HSA-109704 PI3K Cascade R-HSA-112399 IRS-mediated signalling R-HSA-114604 GPVI-mediated activation cascade R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1226099 Signaling by FGFR in disease R-HSA-1227986 Signaling by ERBB2 R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants R-HSA-1236394 Signaling by ERBB4 R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-1430728 Metabolism R-HSA-1433557 Signaling by SCF-KIT R-HSA-1483255 PI Metabolism R-HSA-1483257 Phospholipid metabolism R-HSA-1500931 Cell-Cell communication R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-1643713 Signaling by EGFR in Cancer R-HSA-1660499 Synthesis of PIPs at the plasma membrane R-HSA-166520 Signalling by NGF R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-177929 Signaling by EGFR R-HSA-180292 GAB1 signalosome R-HSA-1839117 Signaling by FGFR1 fusion mutants R-HSA-1839124 FGFR1 mutant receptor activation R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-190236 Signaling by FGFR R-HSA-194138 Signaling by VEGF R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-202403 TCR signaling R-HSA-202424 Downstream TCR signaling R-HSA-202733 Cell surface interactions at the vascular wall R-HSA-2029480 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029485 Role of phospholipids in phagocytosis R-HSA-210993 Tie2 Signaling R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-372790 Signaling by GPCR R-HSA-373753 Nephrin interactions R-HSA-388396 GPCR downstream signaling R-HSA-388841 Costimulation by the CD28 family R-HSA-389356 CD28 co-stimulation R-HSA-389357 CD28 dependent PI3K/Akt signaling R-HSA-392451 G beta:gamma signalling through PI3Kgamma R-HSA-397795 G-protein beta:gamma signalling R-HSA-416476 G alpha (q) signalling events R-HSA-416482 G alpha (12/13) signalling events R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-5637810 Constitutive Signaling by EGFRvIII R-HSA-5637812 Signaling by EGFRvIII in Cancer R-HSA-5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5655253 Signaling by FGFR2 in disease R-HSA-5655272 Signaling by FGFR3 mutants R-HSA-5655291 Signaling by FGFR4 in disease R-HSA-5655302 Signaling by FGFR1 in disease R-HSA-5655304 Signaling by FGFR2 mutants R-HSA-5655311 Signaling by FGFR1 mutants R-HSA-5655324 Signaling by FGFR4 mutants R-HSA-5655332 Signaling by FGFR3 in disease R-HSA-5663202 Diseases of signal transduction R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-912526 Interleukin receptor SHC signaling R-HSA-912631 Regulation of signaling by CBL R-HSA-983705 Signaling by the B Cell Receptor (BCR)","cytosol TAS GO:0005829 plasma membrane IBA GO:0005886 phosphatidylinositol 3-kinase complex ISS GO:0005942 phosphatidylinositol 3-kinase complex, class IA IDA 22402981 GO:0005943 lamellipodium IEA GO:0030027",angiogenesis GO:0001525 IEA liver development GO:0001889 IEA vasculature development GO:0001944 TAS 19200708 glucose metabolic process GO:0006006 IEA protein phosphorylation GO:0006468 IEA phosphatidylinositol biosynthetic process GO:0006661 TAS epidermal growth factor receptor signaling pathway GO:0007173 TAS regulation of gene expression GO:0010468 IEA regulation of phosphatidylinositol 3-kinase signaling GO:0014066 TAS platelet activation GO:0030168 TAS 21035500 T cell costimulation GO:0031295 TAS activation of protein kinase activity GO:0032147 IEA positive regulation of peptidyl-serine phosphorylation GO:0033138 IEA phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IEA insulin receptor signaling pathway via phosphatidylinositol 3-kinase GO:0038028 TAS 19200708 Fc-epsilon receptor signaling pathway GO:0038095 TAS Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038096 TAS ERBB2 signaling pathway GO:0038128 TAS regulation of multicellular organism growth GO:0040014 IEA regulation of cellular respiration GO:0043457 IEA protein kinase B signaling GO:0043491 IEA negative regulation of neuron apoptotic process GO:0043524 IEA endothelial cell migration GO:0043542 TAS 19200708 hypomethylation of CpG island GO:0044029 IEA phosphatidylinositol phosphorylation GO:0046854 ISS vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS phosphatidylinositol-mediated signaling GO:0048015 TAS T cell receptor signaling pathway GO:0050852 TAS leukocyte migration GO:0050900 TAS cardiac muscle contraction GO:0060048 TAS 19147653 adipose tissue development GO:0060612 IEA cellular response to glucose stimulus GO:0071333 IEA energy homeostasis GO:0097009 IEA mitophagy in response to mitochondrial depolarization GO:0098779 IGI 22020285 negative regulation of fibroblast apoptotic process GO:2000270 IEA regulation of genetic imprinting GO:2000653 IEA negative regulation of anoikis GO:2000811 IMP 22402981,"IEA GO:0004674 protein serine/threonine kinase activity 10490823 16043515 17475214 19411071 19574958 20018188 22402981 23643389 23676467 24189400 25814554 26496610 IPI GO:0005515 protein binding IEA GO:0005524 ATP binding TAS GO:0016301 kinase activity 2174051 IDA GO:0016303 1-phosphatidylinositol-3-kinase activity TAS GO:0016303 1-phosphatidylinositol-3-kinase activity IEA GO:0030295 protein kinase activator activity ISS GO:0035004 phosphatidylinositol 3-kinase activity 19200708 TAS GO:0035004 phosphatidylinositol 3-kinase activity IBA GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA GO:0043560 insulin receptor substrate binding IBA GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity",hsa00562 Inositol phosphate metabolism - Homo sapiens (human) hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human) hsa04071 Sphingolipid signaling pathway - Homo sapiens (human) hsa04150 mTOR signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04152 AMPK signaling pathway - Homo sapiens (human) hsa04210 Apoptosis - Homo sapiens (human) hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04370 VEGF signaling pathway - Homo sapiens (human) hsa04380 Osteoclast differentiation - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04611 Platelet activation - Homo sapiens (human) hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04660 T cell receptor signaling pathway - Homo sapiens (human) hsa04662 B cell receptor signaling pathway - Homo sapiens (human) hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04668 TNF signaling pathway - Homo sapiens (human) hsa04670 Leukocyte transendothelial migration - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human) hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04910 Insulin signaling pathway - Homo sapiens (human) hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04915 Estrogen signaling pathway - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04921 Oxytocin signaling pathway - Homo sapiens (human) hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04930 Type II diabetes mellitus - Homo sapiens (human) hsa04932 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human) hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human) hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05146 Amoebiasis - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human) hsa05161 Hepatitis B - Homo sapiens (human) hsa05162 Measles - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05166 HTLV-I infection - Homo sapiens (human) hsa05169 Epstein-Barr virus infection - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05210 Colorectal cancer - Homo sapiens (human) hsa05211 Renal cell carcinoma - Homo sapiens (human) hsa05212 Pancreatic cancer - Homo sapiens (human) hsa05213 Endometrial cancer - Homo sapiens (human) hsa05214 Glioma - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05218 Melanoma - Homo sapiens (human) hsa05220 Chronic myeloid leukemia - Homo sapiens (human) hsa05221 Acute myeloid leukemia - Homo sapiens (human) hsa05222 Small cell lung cancer - Homo sapiens (human) hsa05223 Non-small cell lung cancer - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human) hsa05231 Choline metabolism in cancer - Homo sapiens (human),CHEMBL CHEMBL2064328,P42338,PI3-kinase p110-beta subunit,1.0,ORTHOGONAL,NO,CC(Nc1ccccc1)c2cc(C)cc3C(=O)C=C(Oc23)N4CCOCC4,4,12,"InChI=1S/C22H24N2O3/c1-15-12-18(16(2)23-17-6-4-3-5-7-17)22-19(13-15)20(25)14-21(27-22)24-8-10-26-11-9-24/h3-7,12-14,16,23H,8-11H2,1-2H3",VRCXIJAYLCUSHC-UHFFFAOYSA-N,"c(""Unchecked"", ""PI3-kinase p110-beta subunit"", ""PI3-kinase p110-gamma subunit"", ""PI3-kinase p110-delta subunit"", ""PI3-kinase p110-alpha subunit"")",5291,PK3CB,"Hemostasis R-HSA-109582 PI3K Cascade R-HSA-109704 IRS-mediated signalling R-HSA-112399 GPVI-mediated activation cascade R-HSA-114604 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 PI3K events in ERBB4 signaling R-HSA-1250342 PIP3 activates AKT signaling R-HSA-1257604 Cytokine Signaling in Immune system R-HSA-1280215 Adaptive Immune System R-HSA-1280218 Metabolism R-HSA-1430728 Signaling by SCF-KIT R-HSA-1433557 PI Metabolism R-HSA-1483255 Phospholipid metabolism R-HSA-1483257 Cell-Cell communication R-HSA-1500931 Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Synthesis of PIPs at the plasma membrane R-HSA-1660499 Signalling by NGF R-HSA-166520 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Signaling by EGFR R-HSA-177929 GAB1 signalosome R-HSA-180292 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signaling by FGFR R-HSA-190236 Signaling by VEGF R-HSA-194138 PI3K events in ERBB2 signaling R-HSA-1963642 PI3K/AKT activation R-HSA-198203 TCR signaling R-HSA-202403 Downstream TCR signaling R-HSA-202424 Cell surface interactions at the vascular wall R-HSA-202733 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 Role of phospholipids in phagocytosis R-HSA-2029485 Tie2 Signaling R-HSA-210993 DAP12 interactions R-HSA-2172127 PI3K/AKT Signaling in Cancer R-HSA-2219528 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 Signaling by GPCR R-HSA-372790 Nephrin interactions R-HSA-373753 GPCR downstream signaling R-HSA-388396 G beta:gamma signalling through PI3Kgamma R-HSA-392451 G-protein beta:gamma signalling R-HSA-397795 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signaling by Interleukins R-HSA-449147 Interleukin-2 signaling R-HSA-451927 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 Metabolism of lipids and lipoproteins R-HSA-556833 Downstream signaling of activated FGFR1 R-HSA-5654687 PI-3K cascade:FGFR1 R-HSA-5654689 PI-3K cascade:FGFR2 R-HSA-5654695 Downstream signaling of activated FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR3 R-HSA-5654708 PI-3K cascade:FGFR3 R-HSA-5654710 Downstream signaling of activated FGFR4 R-HSA-5654716 PI-3K cascade:FGFR4 R-HSA-5654720 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 Diseases of signal transduction R-HSA-5663202 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Platelet activation, signaling and aggregation R-HSA-76002 Interleukin receptor SHC signaling R-HSA-912526 Regulation of signaling by CBL R-HSA-912631 Signaling by the B Cell Receptor (BCR) R-HSA-983705",IDA GO:0005634 nucleus IDA GO:0005730 nucleolus TAS GO:0005829 cytosol IBA GO:0005886 plasma membrane IBA GO:0005942 phosphatidylinositol 3-kinase complex IDA GO:0045171 intercellular bridge,10570282 GO:0000187 activation of MAPK activity TAS GO:0001935 endothelial cell proliferation IEA 25139353 GO:0001952 regulation of cell-matrix adhesion IMP GO:0006661 phosphatidylinositol biosynthetic process TAS GO:0006874 cellular calcium ion homeostasis IEA GO:0006914 autophagy IEA 10570282 GO:0006935 chemotaxis TAS GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA 10570282 GO:0007165 signal transduction NAS 21035500 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 21321382 GO:0007186 G-protein coupled receptor signaling pathway TAS 21321382 GO:0010508 positive regulation of autophagy TAS 25139353 GO:0010628 positive regulation of gene expression IMP 21321382 GO:0014065 phosphatidylinositol 3-kinase signaling TAS GO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS 21035500 21321382 GO:0016477 cell migration TAS 21035500 GO:0030168 platelet activation TAS GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA GO:0038095 Fc-epsilon receptor signaling pathway TAS GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS GO:0040016 embryonic cleavage IEA GO:0046854 phosphatidylinositol phosphorylation IEA GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS GO:0048015 phosphatidylinositol-mediated signaling TAS GO:0050852 T cell receptor signaling pathway TAS GO:0050900 leukocyte migration TAS GO:0060055 angiogenesis involved in wound healing IEA 21035500 GO:0070527 platelet aggregation TAS 21321382 GO:2000369 regulation of clathrin-mediated endocytosis TAS,"19380743 22402981 23397142 25241761 25556234 26496610 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0016303 1-phosphatidylinositol-3-kinase activity TAS 21035500 GO:0035004 phosphatidylinositol 3-kinase activity TAS GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA GO:0043560 insulin receptor substrate binding IEA GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity IBA GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS",hsa00562 Inositol phosphate metabolism - Homo sapiens (human) hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human) hsa04071 Sphingolipid signaling pathway - Homo sapiens (human) hsa04150 mTOR signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04152 AMPK signaling pathway - Homo sapiens (human) hsa04210 Apoptosis - Homo sapiens (human) hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04370 VEGF signaling pathway - Homo sapiens (human) hsa04380 Osteoclast differentiation - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04611 Platelet activation - Homo sapiens (human) hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04660 T cell receptor signaling pathway - Homo sapiens (human) hsa04662 B cell receptor signaling pathway - Homo sapiens (human) hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04668 TNF signaling pathway - Homo sapiens (human) hsa04670 Leukocyte transendothelial migration - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human) hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04910 Insulin signaling pathway - Homo sapiens (human) hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04915 Estrogen signaling pathway - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04921 Oxytocin signaling pathway - Homo sapiens (human) hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04930 Type II diabetes mellitus - Homo sapiens (human) hsa04932 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human) hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human) hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05146 Amoebiasis - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human) hsa05161 Hepatitis B - Homo sapiens (human) hsa05162 Measles - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05166 HTLV-I infection - Homo sapiens (human) hsa05169 Epstein-Barr virus infection - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05210 Colorectal cancer - Homo sapiens (human) hsa05211 Renal cell carcinoma - Homo sapiens (human) hsa05212 Pancreatic cancer - Homo sapiens (human) hsa05213 Endometrial cancer - Homo sapiens (human) hsa05214 Glioma - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05218 Melanoma - Homo sapiens (human) hsa05220 Chronic myeloid leukemia - Homo sapiens (human) hsa05221 Acute myeloid leukemia - Homo sapiens (human) hsa05222 Small cell lung cancer - Homo sapiens (human) hsa05223 Non-small cell lung cancer - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human) hsa05231 Choline metabolism in cancer - Homo sapiens (human),CHEMBL CHEMBL1972466,P42338,PI3-kinase p110-beta subunit,1.0,PRIMARY,NO,CC(Nc1ccccc1)C2=CC(=CN3C(=O)C=C(N=C23)N4CCOCC4)C,4,35,"InChI=1S/C21H24N4O2/c1-15-12-18(16(2)22-17-6-4-3-5-7-17)21-23-19(13-20(26)25(21)14-15)24-8-10-27-11-9-24/h3-7,12-14,16,22H,8-11H2,1-2H3",CPRAGQJXBLMUEL-UHFFFAOYSA-N,"c(""Focal adhesion kinase 1"", ""Casein kinase I alpha"", ""Dual specificity protein kinase CLK4"", ""Unchecked"", ""PI3-kinase p110-beta subunit"", ""PI3-kinase p110-gamma subunit"", ""PI3-kinase p110-delta subunit"", ""PI3-kinase p110-alpha subunit"")",5291,PK3CB,"Hemostasis R-HSA-109582 PI3K Cascade R-HSA-109704 IRS-mediated signalling R-HSA-112399 GPVI-mediated activation cascade R-HSA-114604 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 PI3K events in ERBB4 signaling R-HSA-1250342 PIP3 activates AKT signaling R-HSA-1257604 Cytokine Signaling in Immune system R-HSA-1280215 Adaptive Immune System R-HSA-1280218 Metabolism R-HSA-1430728 Signaling by SCF-KIT R-HSA-1433557 PI Metabolism R-HSA-1483255 Phospholipid metabolism R-HSA-1483257 Cell-Cell communication R-HSA-1500931 Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Synthesis of PIPs at the plasma membrane R-HSA-1660499 Signalling by NGF R-HSA-166520 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Signaling by EGFR R-HSA-177929 GAB1 signalosome R-HSA-180292 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signaling by FGFR R-HSA-190236 Signaling by VEGF R-HSA-194138 PI3K events in ERBB2 signaling R-HSA-1963642 PI3K/AKT activation R-HSA-198203 TCR signaling R-HSA-202403 Downstream TCR signaling R-HSA-202424 Cell surface interactions at the vascular wall R-HSA-202733 Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-2029480 Role of phospholipids in phagocytosis R-HSA-2029485 Tie2 Signaling R-HSA-210993 DAP12 interactions R-HSA-2172127 PI3K/AKT Signaling in Cancer R-HSA-2219528 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2219530 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2730905 Signaling by GPCR R-HSA-372790 Nephrin interactions R-HSA-373753 GPCR downstream signaling R-HSA-388396 G beta:gamma signalling through PI3Kgamma R-HSA-392451 G-protein beta:gamma signalling R-HSA-397795 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signaling by Interleukins R-HSA-449147 Interleukin-2 signaling R-HSA-451927 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 Metabolism of lipids and lipoproteins R-HSA-556833 Downstream signaling of activated FGFR1 R-HSA-5654687 PI-3K cascade:FGFR1 R-HSA-5654689 PI-3K cascade:FGFR2 R-HSA-5654695 Downstream signaling of activated FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR3 R-HSA-5654708 PI-3K cascade:FGFR3 R-HSA-5654710 Downstream signaling of activated FGFR4 R-HSA-5654716 PI-3K cascade:FGFR4 R-HSA-5654720 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 Diseases of signal transduction R-HSA-5663202 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Platelet activation, signaling and aggregation R-HSA-76002 Interleukin receptor SHC signaling R-HSA-912526 Regulation of signaling by CBL R-HSA-912631 Signaling by the B Cell Receptor (BCR) R-HSA-983705",IDA GO:0005634 nucleus IDA GO:0005730 nucleolus TAS GO:0005829 cytosol IBA GO:0005886 plasma membrane IBA GO:0005942 phosphatidylinositol 3-kinase complex IDA GO:0045171 intercellular bridge,10570282 GO:0000187 activation of MAPK activity TAS GO:0001935 endothelial cell proliferation IEA 25139353 GO:0001952 regulation of cell-matrix adhesion IMP GO:0006661 phosphatidylinositol biosynthetic process TAS GO:0006874 cellular calcium ion homeostasis IEA GO:0006914 autophagy IEA 10570282 GO:0006935 chemotaxis TAS GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA 10570282 GO:0007165 signal transduction NAS 21035500 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS 21321382 GO:0007186 G-protein coupled receptor signaling pathway TAS 21321382 GO:0010508 positive regulation of autophagy TAS 25139353 GO:0010628 positive regulation of gene expression IMP 21321382 GO:0014065 phosphatidylinositol 3-kinase signaling TAS GO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS 21035500 21321382 GO:0016477 cell migration TAS 21035500 GO:0030168 platelet activation TAS GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA GO:0038095 Fc-epsilon receptor signaling pathway TAS GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS GO:0040016 embryonic cleavage IEA GO:0046854 phosphatidylinositol phosphorylation IEA GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS GO:0048015 phosphatidylinositol-mediated signaling TAS GO:0050852 T cell receptor signaling pathway TAS GO:0050900 leukocyte migration TAS GO:0060055 angiogenesis involved in wound healing IEA 21035500 GO:0070527 platelet aggregation TAS 21321382 GO:2000369 regulation of clathrin-mediated endocytosis TAS,"19380743 22402981 23397142 25241761 25556234 26496610 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0016303 1-phosphatidylinositol-3-kinase activity TAS 21035500 GO:0035004 phosphatidylinositol 3-kinase activity TAS GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA GO:0043560 insulin receptor substrate binding IEA GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity IBA GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS",hsa00562 Inositol phosphate metabolism - Homo sapiens (human) hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human) hsa04071 Sphingolipid signaling pathway - Homo sapiens (human) hsa04150 mTOR signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04152 AMPK signaling pathway - Homo sapiens (human) hsa04210 Apoptosis - Homo sapiens (human) hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04370 VEGF signaling pathway - Homo sapiens (human) hsa04380 Osteoclast differentiation - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04611 Platelet activation - Homo sapiens (human) hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04660 T cell receptor signaling pathway - Homo sapiens (human) hsa04662 B cell receptor signaling pathway - Homo sapiens (human) hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04668 TNF signaling pathway - Homo sapiens (human) hsa04670 Leukocyte transendothelial migration - Homo sapiens (human) hsa04722 Neurotrophin signaling pathway - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human) hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04910 Insulin signaling pathway - Homo sapiens (human) hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04915 Estrogen signaling pathway - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04921 Oxytocin signaling pathway - Homo sapiens (human) hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04930 Type II diabetes mellitus - Homo sapiens (human) hsa04932 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human) hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human) hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05146 Amoebiasis - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human) hsa05161 Hepatitis B - Homo sapiens (human) hsa05162 Measles - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05166 HTLV-I infection - Homo sapiens (human) hsa05169 Epstein-Barr virus infection - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05210 Colorectal cancer - Homo sapiens (human) hsa05211 Renal cell carcinoma - Homo sapiens (human) hsa05212 Pancreatic cancer - Homo sapiens (human) hsa05213 Endometrial cancer - Homo sapiens (human) hsa05214 Glioma - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05218 Melanoma - Homo sapiens (human) hsa05220 Chronic myeloid leukemia - Homo sapiens (human) hsa05221 Acute myeloid leukemia - Homo sapiens (human) hsa05222 Small cell lung cancer - Homo sapiens (human) hsa05223 Non-small cell lung cancer - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human) hsa05231 Choline metabolism in cancer - Homo sapiens (human),CHEMBL CHEMBL2171944,O00329,PI3-kinase p110-delta subunit,1.0,ORTHOGONAL,NO,CCc1nc2ccccc2n1c3nc(N4CCOCC4)c5nc(CN6CCC(CC6)C(C)(C)O)n(C)c5n3,3,12,"InChI=1S/C28H38N8O2/c1-5-22-29-20-8-6-7-9-21(20)36(22)27-31-25-24(26(32-27)35-14-16-38-17-15-35)30-23(33(25)4)18-34-12-10-19(11-13-34)28(2,3)37/h6-9,19,37H,5,10-18H2,1-4H3",BHXSZKLTWORWNB-UHFFFAOYSA-N,"c(""Unchecked"", ""PI3-kinase p110-beta subunit"", ""PI3-kinase p110-delta subunit"", ""PI3-kinase p110-gamma subunit"")",5293,PK3CD,"R-HSA-109582 Hemostasis R-HSA-114604 GPVI-mediated activation cascade R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-1430728 Metabolism R-HSA-1433557 Signaling by SCF-KIT R-HSA-1483255 PI Metabolism R-HSA-1483257 Phospholipid metabolism R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-1660499 Synthesis of PIPs at the plasma membrane R-HSA-166520 Signalling by NGF R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-177929 Signaling by EGFR R-HSA-180292 GAB1 signalosome R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-190236 Signaling by FGFR R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2424491 DAP12 signaling R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-372790 Signaling by GPCR R-HSA-388396 GPCR downstream signaling R-HSA-392451 G beta:gamma signalling through PI3Kgamma R-HSA-397795 G-protein beta:gamma signalling R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5663202 Diseases of signal transduction R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-912526 Interleukin receptor SHC signaling R-HSA-912631 Regulation of signaling by CBL R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983705 Signaling by the B Cell Receptor (BCR)",GO:0005829 cytosol TAS GO:0005886 plasma membrane IBA GO:0005886 plasma membrane TAS GO:0005942 phosphatidylinositol 3-kinase complex IBA 9113989 9235916 GO:0005942 phosphatidylinositol 3-kinase complex NAS GO:0042629 mast cell granule IEA,natural killer cell differentiation GO:0001779 TAS 20940048 cytokine production GO:0001816 TAS 20940048 adaptive immune response GO:0002250 TAS 17290298 mast cell chemotaxis GO:0002551 TAS 20940048 respiratory burst involved in defense response GO:0002679 TAS 20940048 protein phosphorylation GO:0006468 NAS 9113989 phosphatidylinositol biosynthetic process GO:0006661 TAS inflammatory response GO:0006954 TAS 17290298 20940048 signal transduction GO:0007165 NAS 9113989 positive regulation of gene expression GO:0010628 IMP 22079609 T cell chemotaxis GO:0010818 TAS 20940048 phosphatidylinositol 3-kinase signaling GO:0014065 TAS 17290298 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 TAS natural killer cell activation GO:0030101 TAS 20940048 T cell differentiation GO:0030217 TAS 20940048 positive regulation of cell migration GO:0030335 IMP 22079609 neutrophil chemotaxis GO:0030593 TAS 20940048 natural killer cell chemotaxis GO:0035747 TAS 20940048 B cell chemotaxis GO:0035754 TAS 20940048 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IEA T cell activation GO:0042110 TAS 20940048 B cell activation GO:0042113 TAS 20940048 mast cell degranulation GO:0043303 TAS 20940048 innate immune response GO:0045087 TAS 17290298 20940048 phosphatidylinositol phosphorylation GO:0046854 IEA phosphatidylinositol-mediated signaling GO:0048015 TAS T cell receptor signaling pathway GO:0050852 TAS 20940048 B cell receptor signaling pathway GO:0050853 TAS 20940048 mast cell differentiation GO:0060374 TAS 20940048 neutrophil extravasation GO:0072672 TAS 20940048,"IPI 22020336 protein binding GO:0005515 IEA GO:0005524 ATP binding IBA GO:0016303 1-phosphatidylinositol-3-kinase activity NAS 9235916 1-phosphatidylinositol-3-kinase activity GO:0016303 TAS 17290298 phosphatidylinositol 3-kinase activity GO:0035004 IBA GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity TAS GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity",Inositol phosphate metabolism - Homo sapiens (human) hsa00562 ErbB signaling pathway - Homo sapiens (human) hsa04012 Ras signaling pathway - Homo sapiens (human) hsa04014 Rap1 signaling pathway - Homo sapiens (human) hsa04015 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 cAMP signaling pathway - Homo sapiens (human) hsa04024 Chemokine signaling pathway - Homo sapiens (human) hsa04062 HIF-1 signaling pathway - Homo sapiens (human) hsa04066 FoxO signaling pathway - Homo sapiens (human) hsa04068 Phosphatidylinositol signaling system - Homo sapiens (human) hsa04070 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 mTOR signaling pathway - Homo sapiens (human) hsa04150 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 AMPK signaling pathway - Homo sapiens (human) hsa04152 Apoptosis - Homo sapiens (human) hsa04210 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04261 VEGF signaling pathway - Homo sapiens (human) hsa04370 Osteoclast differentiation - Homo sapiens (human) hsa04380 Focal adhesion - Homo sapiens (human) hsa04510 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04550 Platelet activation - Homo sapiens (human) hsa04611 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04620 Jak-STAT signaling pathway - Homo sapiens (human) hsa04630 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04650 T cell receptor signaling pathway - Homo sapiens (human) hsa04660 B cell receptor signaling pathway - Homo sapiens (human) hsa04662 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04664 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04666 TNF signaling pathway - Homo sapiens (human) hsa04668 Leukocyte transendothelial migration - Homo sapiens (human) hsa04670 Neurotrophin signaling pathway - Homo sapiens (human) hsa04722 Cholinergic synapse - Homo sapiens (human) hsa04725 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04750 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04810 Insulin signaling pathway - Homo sapiens (human) hsa04910 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04914 Estrogen signaling pathway - Homo sapiens (human) hsa04915 Prolactin signaling pathway - Homo sapiens (human) hsa04917 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04919 Oxytocin signaling pathway - Homo sapiens (human) hsa04921 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04923 Type II diabetes mellitus - Homo sapiens (human) hsa04930 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa04932 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) hsa04960 Carbohydrate digestion and absorption - Homo sapiens (human) hsa04973 Bacterial invasion of epithelial cells - Homo sapiens (human) hsa05100 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05142 Toxoplasmosis - Homo sapiens (human) hsa05145 Amoebiasis - Homo sapiens (human) hsa05146 Hepatitis C - Homo sapiens (human) hsa05160 Hepatitis B - Homo sapiens (human) hsa05161 Measles - Homo sapiens (human) hsa05162 Influenza A - Homo sapiens (human) hsa05164 HTLV-I infection - Homo sapiens (human) hsa05166 Epstein-Barr virus infection - Homo sapiens (human) hsa05169 Pathways in cancer - Homo sapiens (human) hsa05200 Viral carcinogenesis - Homo sapiens (human) hsa05203 Proteoglycans in cancer - Homo sapiens (human) hsa05205 Colorectal cancer - Homo sapiens (human) hsa05210 Renal cell carcinoma - Homo sapiens (human) hsa05211 Pancreatic cancer - Homo sapiens (human) hsa05212 Endometrial cancer - Homo sapiens (human) hsa05213 Glioma - Homo sapiens (human) hsa05214 Prostate cancer - Homo sapiens (human) hsa05215 Melanoma - Homo sapiens (human) hsa05218 Chronic myeloid leukemia - Homo sapiens (human) hsa05220 Acute myeloid leukemia - Homo sapiens (human) hsa05221 Small cell lung cancer - Homo sapiens (human) hsa05222 Non-small cell lung cancer - Homo sapiens (human) hsa05223 Central carbon metabolism in cancer - Homo sapiens (human) hsa05230 Choline metabolism in cancer - Homo sapiens (human) hsa05231,CHEMBL CHEMBL3403664,O00329,PI3-kinase p110-delta subunit,1.0,PRIMARY,NO,C[C@H](Nc1ncnc(N)c1C#N)c2nc3ccc(F)cc3c(c2c4ccccc4)S(=O)(=O)C,4,5,"InChI=1S/C23H19FN6O2S/c1-13(29-23-17(11-25)22(26)27-12-28-23)20-19(14-6-4-3-5-7-14)21(33(2,31)32)16-10-15(24)8-9-18(16)30-20/h3-10,12-13H,1-2H3,(H3,26,27,28,29)/t13-/m0/s1",HFVANGZKKLPTDI-ZDUSSCGKSA-N,"c(""PI3-kinase p110-delta subunit"", ""PI3-kinase p110-gamma subunit"", ""PI3-kinase p110-beta subunit"", ""PI3-kinase p110-alpha subunit"")",5293,PK3CD,"R-HSA-109582 Hemostasis R-HSA-114604 GPVI-mediated activation cascade R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-1430728 Metabolism R-HSA-1433557 Signaling by SCF-KIT R-HSA-1483255 PI Metabolism R-HSA-1483257 Phospholipid metabolism R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-1660499 Synthesis of PIPs at the plasma membrane R-HSA-166520 Signalling by NGF R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-177929 Signaling by EGFR R-HSA-180292 GAB1 signalosome R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-190236 Signaling by FGFR R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2424491 DAP12 signaling R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-372790 Signaling by GPCR R-HSA-388396 GPCR downstream signaling R-HSA-392451 G beta:gamma signalling through PI3Kgamma R-HSA-397795 G-protein beta:gamma signalling R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-556833 Metabolism of lipids and lipoproteins R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5663202 Diseases of signal transduction R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-912526 Interleukin receptor SHC signaling R-HSA-912631 Regulation of signaling by CBL R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983705 Signaling by the B Cell Receptor (BCR)",GO:0005829 cytosol TAS GO:0005886 plasma membrane IBA GO:0005886 plasma membrane TAS GO:0005942 phosphatidylinositol 3-kinase complex IBA 9113989 9235916 GO:0005942 phosphatidylinositol 3-kinase complex NAS GO:0042629 mast cell granule IEA,natural killer cell differentiation GO:0001779 TAS 20940048 cytokine production GO:0001816 TAS 20940048 adaptive immune response GO:0002250 TAS 17290298 mast cell chemotaxis GO:0002551 TAS 20940048 respiratory burst involved in defense response GO:0002679 TAS 20940048 protein phosphorylation GO:0006468 NAS 9113989 phosphatidylinositol biosynthetic process GO:0006661 TAS inflammatory response GO:0006954 TAS 17290298 20940048 signal transduction GO:0007165 NAS 9113989 positive regulation of gene expression GO:0010628 IMP 22079609 T cell chemotaxis GO:0010818 TAS 20940048 phosphatidylinositol 3-kinase signaling GO:0014065 TAS 17290298 regulation of phosphatidylinositol 3-kinase signaling GO:0014066 TAS natural killer cell activation GO:0030101 TAS 20940048 T cell differentiation GO:0030217 TAS 20940048 positive regulation of cell migration GO:0030335 IMP 22079609 neutrophil chemotaxis GO:0030593 TAS 20940048 natural killer cell chemotaxis GO:0035747 TAS 20940048 B cell chemotaxis GO:0035754 TAS 20940048 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 IEA T cell activation GO:0042110 TAS 20940048 B cell activation GO:0042113 TAS 20940048 mast cell degranulation GO:0043303 TAS 20940048 innate immune response GO:0045087 TAS 17290298 20940048 phosphatidylinositol phosphorylation GO:0046854 IEA phosphatidylinositol-mediated signaling GO:0048015 TAS T cell receptor signaling pathway GO:0050852 TAS 20940048 B cell receptor signaling pathway GO:0050853 TAS 20940048 mast cell differentiation GO:0060374 TAS 20940048 neutrophil extravasation GO:0072672 TAS 20940048,"IPI 22020336 protein binding GO:0005515 IEA GO:0005524 ATP binding IBA GO:0016303 1-phosphatidylinositol-3-kinase activity NAS 9235916 1-phosphatidylinositol-3-kinase activity GO:0016303 TAS 17290298 phosphatidylinositol 3-kinase activity GO:0035004 IBA GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity TAS GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity",Inositol phosphate metabolism - Homo sapiens (human) hsa00562 ErbB signaling pathway - Homo sapiens (human) hsa04012 Ras signaling pathway - Homo sapiens (human) hsa04014 Rap1 signaling pathway - Homo sapiens (human) hsa04015 cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 cAMP signaling pathway - Homo sapiens (human) hsa04024 Chemokine signaling pathway - Homo sapiens (human) hsa04062 HIF-1 signaling pathway - Homo sapiens (human) hsa04066 FoxO signaling pathway - Homo sapiens (human) hsa04068 Phosphatidylinositol signaling system - Homo sapiens (human) hsa04070 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 mTOR signaling pathway - Homo sapiens (human) hsa04150 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 AMPK signaling pathway - Homo sapiens (human) hsa04152 Apoptosis - Homo sapiens (human) hsa04210 Adrenergic signaling in cardiomyocytes - Homo sapiens (human) hsa04261 VEGF signaling pathway - Homo sapiens (human) hsa04370 Osteoclast differentiation - Homo sapiens (human) hsa04380 Focal adhesion - Homo sapiens (human) hsa04510 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04550 Platelet activation - Homo sapiens (human) hsa04611 Toll-like receptor signaling pathway - Homo sapiens (human) hsa04620 Jak-STAT signaling pathway - Homo sapiens (human) hsa04630 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04650 T cell receptor signaling pathway - Homo sapiens (human) hsa04660 B cell receptor signaling pathway - Homo sapiens (human) hsa04662 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04664 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04666 TNF signaling pathway - Homo sapiens (human) hsa04668 Leukocyte transendothelial migration - Homo sapiens (human) hsa04670 Neurotrophin signaling pathway - Homo sapiens (human) hsa04722 Cholinergic synapse - Homo sapiens (human) hsa04725 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04750 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04810 Insulin signaling pathway - Homo sapiens (human) hsa04910 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04914 Estrogen signaling pathway - Homo sapiens (human) hsa04915 Prolactin signaling pathway - Homo sapiens (human) hsa04917 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04919 Oxytocin signaling pathway - Homo sapiens (human) hsa04921 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04923 Type II diabetes mellitus - Homo sapiens (human) hsa04930 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa04932 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) hsa04960 Carbohydrate digestion and absorption - Homo sapiens (human) hsa04973 Bacterial invasion of epithelial cells - Homo sapiens (human) hsa05100 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05142 Toxoplasmosis - Homo sapiens (human) hsa05145 Amoebiasis - Homo sapiens (human) hsa05146 Hepatitis C - Homo sapiens (human) hsa05160 Hepatitis B - Homo sapiens (human) hsa05161 Measles - Homo sapiens (human) hsa05162 Influenza A - Homo sapiens (human) hsa05164 HTLV-I infection - Homo sapiens (human) hsa05166 Epstein-Barr virus infection - Homo sapiens (human) hsa05169 Pathways in cancer - Homo sapiens (human) hsa05200 Viral carcinogenesis - Homo sapiens (human) hsa05203 Proteoglycans in cancer - Homo sapiens (human) hsa05205 Colorectal cancer - Homo sapiens (human) hsa05210 Renal cell carcinoma - Homo sapiens (human) hsa05211 Pancreatic cancer - Homo sapiens (human) hsa05212 Endometrial cancer - Homo sapiens (human) hsa05213 Glioma - Homo sapiens (human) hsa05214 Prostate cancer - Homo sapiens (human) hsa05215 Melanoma - Homo sapiens (human) hsa05218 Chronic myeloid leukemia - Homo sapiens (human) hsa05220 Acute myeloid leukemia - Homo sapiens (human) hsa05221 Small cell lung cancer - Homo sapiens (human) hsa05222 Non-small cell lung cancer - Homo sapiens (human) hsa05223 Central carbon metabolism in cancer - Homo sapiens (human) hsa05230 Choline metabolism in cancer - Homo sapiens (human) hsa05231,CHEMBL CHEMBL3606021,P09874,Poly [ADP-ribose] polymerase-1,1.0,PRIMARY,NO,NC(=O)c1cc(F)cc2CN(C3CCN(CC3)C4CCC(F)(F)CC4)C(=O)c12,54,67,"InChI=1S/C20H24F3N3O2/c21-13-9-12-11-26(19(28)17(12)16(10-13)18(24)27)15-3-7-25(8-4-15)14-1-5-20(22,23)6-2-14/h9-10,14-15H,1-8,11H2,(H2,24,27)",ARYVAQSYRLZVQD-UHFFFAOYSA-N,"c(""Poly [ADP-ribose] polymerase-1"", ""Unchecked"", ""Poly [ADP-ribose] polymerase 2"", ""MCF7"", ""Tyrosine-protein kinase ABL"", ""Tyrosine kinase non-receptor protein 2"", ""Serine/threonine-protein kinase AKT"", ""ALK tyrosine kinase receptor"", ""Serine/threonine-protein kinase Aurora-B"", ""Serine/threonine-protein kinase Aurora-A"", ""Tyrosine-protein kinase BRK"", ""Mitotic checkpoint serine/threonine-protein kinase BUB1"", ""CDC7/DBF4 (Cell division cycle 7-related protein kinase/Activator of S phase kinase)"", ""CDK2/Cyclin A"", ""Serine/threonine-protein kinase Chk1"", ""Serine/threonine-protein kinase EEF2K"", ""Epidermal growth factor receptor erbB1"", ""MAP kinase ERK2"", ""Ephrin type-A receptor 2"", ""Focal adhesion kinase 1"", ""Fibroblast growth factor receptor 1"", ""Tyrosine-protein kinase receptor FLT3"", ""Glycogen synthase kinase-3 beta"", ""Serine/threonine-protein kinase haspin"", ""IGF-like family receptor 1"", ""Inhibitor of nuclear factor kappa B kinase beta subunit"", ""Insulin receptor"", ""Tyrosine-protein kinase JAK1"", ""Tyrosine-protein kinase JAK2"", ""Tyrosine-protein kinase JAK3"", ""Stem cell growth factor receptor"", ""Tyrosine-protein kinase LCK"", ""Tyrosine-protein kinase Lyn"", ""MAP kinase-activated protein kinase 2"", ""Maternal embryonic leucine zipper kinase"", ""Hepatocyte growth factor receptor"", ""MAP kinase signal-integrating kinase 2"", ""Dual specificity protein kinase TTK"", ""Serine/threonine-protein kinase MST4"", ""Serine/threonine-protein kinase NEK6"", ""Serine/threonine-protein kinase NIM1"", ""MAP kinase p38 alpha"", ""Serine/threonine-protein kinase PAK 4"", ""Platelet-derived growth factor receptor beta"", ""3-phosphoinositide dependent protein kinase-1"", ""Eukaryotic translation initiation factor 2-alpha kinase 3"", ""Serine/threonine-protein kinase PIM1"", ""Serine/threonine-protein kinase PIM2"", ""cAMP-dependent protein kinase alpha-catalytic subunit"", ""Protein kinase C beta"", ""Serine/threonine-protein kinase PLK1"", ""Tyrosine-protein kinase receptor RET"", ""Tyrosine-protein kinase SYK"", ""Serine/threonine-protein kinase tousled-like 2"", ""Nerve growth factor receptor Trk-A"", ""Tyrosine-protein kinase TYK2"", ""Vascular endothelial growth factor receptor 2"", ""Tyrosine-protein kinase ZAP-70"")",142,PARP1,POLB-Dependent Long Patch Base Excision Repair R-HSA-110362 Resolution of AP sites via the multiple-nucleotide patch replacement pathway R-HSA-110373 Signal Transduction R-HSA-162582 Signaling by TGF-beta Receptor Complex R-HSA-170834 Generic Transcription Pathway R-HSA-212436 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer R-HSA-2173793 Downregulation of SMAD2/3:SMAD4 transcriptional activity R-HSA-2173795 SUMOylation R-HSA-2990846 SUMOylation of DNA damage response and repair proteins R-HSA-3108214 SUMO E3 ligases SUMOylate target proteins R-HSA-3108232 Metabolism of proteins R-HSA-392499 Post-translational protein modification R-HSA-597592 Base Excision Repair R-HSA-73884 DNA Repair R-HSA-73894 Resolution of Abasic Sites (AP sites) R-HSA-73933 Gene Expression R-HSA-74160,"19135898 GO:0000784 nuclear chromosome, telomeric region IDA 17177976 GO:0005634 nucleus IDA 9518481 GO:0005635 nuclear envelope IDA GO:0005654 nucleoplasm TAS 19303849 GO:0005667 transcription factor complex IDA 9518481 16107709 GO:0005730 nucleolus IDA 25378300 GO:0005739 mitochondrion IDA 19946888 GO:0016020 membrane IDA 25378300 GO:0043234 protein complex IDA","GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS GO:0000715 nucleotide-excision repair, DNA damage recognition TAS GO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS GO:0000724 double-strand break repair via homologous recombination TAS GO:0006273 lagging strand elongation IBA GO:0006281 DNA repair 17396150 TAS GO:0006293 nucleotide-excision repair, preincision complex stabilization TAS GO:0006294 nucleotide-excision repair, preincision complex assembly TAS GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion TAS GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion TAS GO:0006302 double-strand break repair 23230272 IMP GO:0006366 transcription from RNA polymerase II promoter 10944198 TAS GO:0006471 protein ADP-ribosylation 17396150 IDA GO:0006974 cellular response to DNA damage stimulus 24550317 IMP GO:0007005 mitochondrion organization 25378300 IMP GO:0007179 transforming growth factor beta receptor signaling pathway IEA GO:0010613 positive regulation of cardiac muscle hypertrophy ISS GO:0016540 protein autoprocessing IEA GO:0016925 protein sumoylation TAS GO:0023019 signal transduction involved in regulation of gene expression IEA GO:0030225 macrophage differentiation 18309324 TAS GO:0032042 mitochondrial DNA metabolic process 25378300 IMP GO:0032869 cellular response to insulin stimulus 19303849 IDA GO:0033683 nucleotide-excision repair, DNA incision TAS GO:0034599 cellular response to oxidative stress 25378300 IMP GO:0036211 protein modification process 25378300 IMP GO:0042769 DNA damage response, detection of DNA damage IEA GO:0043504 mitochondrial DNA repair 25378300 IMP GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0051103 DNA ligation involved in DNA repair IBA GO:0060391 positive regulation of SMAD protein import into nucleus IEA GO:0070212 protein poly-ADP-ribosylation 15674325 19470756 IDA GO:0070911 global genome nucleotide-excision repair TAS GO:1903827 regulation of cellular protein localization 24550317 IMP GO:1904357 negative regulation of telomere maintenance via telomere lengthening ISS GO:2000679 positive regulation of transcription regulatory region DNA binding IEA",IEA GO:0003677 DNA binding IBA GO:0003910 DNA ligase (ATP) activity IDA 16107709 17396150 19470756 23275542 NAD+ ADP-ribosyltransferase activity GO:0003950 TAS GO:0003950 NAD+ ADP-ribosyltransferase activity IPI 9518481 11248244 14596914 14627987 14734561 15044383 15555565 16490787 17396150 18172500 18971944 19661379 19779455 21266351 21549307 21575865 21577210 22863007 23230272 23481255 24778456 25640309 protein binding GO:0005515 IPI 19303849 transcription factor binding GO:0008134 IEA GO:0008270 zinc ion binding IPI 23382074 enzyme binding GO:0019899 IPI 17177976 protein kinase binding GO:0019901 IPI 14734561 23481255 identical protein binding GO:0042802 IEA GO:0042826 histone deacetylase binding IDA 22658674 22681889 poly(A) RNA binding GO:0044822 IPI 16107709 protein N-terminus binding GO:0047485 IEA GO:0051287 NAD binding IEA GO:0070412 R-SMAD binding,Base excision repair - Homo sapiens (human) hsa03410 NF-kappa B signaling pathway - Homo sapiens (human) hsa04064,CHEMBL CHEMBL3183773,O14649,Potassium channel subfamily K member 3,1.0,ORTHOGONAL,NO,Cc1cccc(c1)C(=O)Nc2cccc(NC(=O)c3cccc(c3)C(F)(F)F)c2,4,11,"InChI=1S/C22H17F3N2O2/c1-14-5-2-6-15(11-14)20(28)26-18-9-4-10-19(13-18)27-21(29)16-7-3-8-17(12-16)22(23,24)25/h2-13H,1H3,(H,26,28)(H,27,29)",ISMGZXXGNKTCRO-UHFFFAOYSA-N,"c(""Potassium channel subfamily K member 9"", ""Potassium channel subfamily K member 3"", ""Unchecked"", ""Voltage-gated potassium channel subunit Kv7.2"", ""Inward rectifier potassium channel 2"")",3777,KCNK3,R-HSA-112316 Neuronal System R-HSA-1296071 Potassium Channels R-HSA-1296346 Tandem pore domain potassium channels R-HSA-1299316 TWIK-releated acid-sensitive K+ channel (TASK),cytosol GO:0005829 IEA plasma membrane GO:0005886 12198146 IMP plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 9312005 TAS,potassium ion transport TAS 9312005 GO:0006813 chemical synaptic transmission TAS 9312005 GO:0007268 brain development IEA GO:0007420 stabilization of membrane potential IBA GO:0030322 ion transmembrane transport IMP 12198146 GO:0034220 response to drug IEA GO:0042493 negative regulation of cytosolic calcium ion concentration IEA GO:0051481 cardiac conduction TAS GO:0061337 cellular response to zinc ion IEA GO:0071294 cellular response to hypoxia IEA GO:0071456 potassium ion transmembrane transport IEA GO:0071805 cochlea development IEA GO:0090102 mitophagy in response to mitochondrial depolarization IGI 22020285 GO:0098779,ion channel activity IMP 12198146 GO:0005216 open rectifier potassium channel activity IEA GO:0005252 potassium channel activity TAS GO:0005267 protein C-terminus binding IEA GO:0008022 potassium ion leak channel activity IDA 9312005 GO:0022841 protein homodimerization activity IEA GO:0042803 S100 protein binding IPI 12198146 GO:0044548 protein heterodimerization activity IEA GO:0046982,,CHEMBL CHEMBL1081188,O14649,Potassium channel subfamily K member 3,1.0,PRIMARY,NO,COc1ccccc1C(=O)Nc2cccc(NC(=O)c3cccc(C)c3)c2,4,12,"InChI=1S/C22H20N2O3/c1-15-7-5-8-16(13-15)21(25)23-17-9-6-10-18(14-17)24-22(26)19-11-3-4-12-20(19)27-2/h3-14H,1-2H3,(H,23,25)(H,24,26)",UTAJHKSGYJSZBR-UHFFFAOYSA-N,"c(""Potassium channel subfamily K member 9"", ""Potassium channel subfamily K member 3"", ""Unchecked"", ""Voltage-gated potassium channel subunit Kv7.2"", ""Inward rectifier potassium channel 2"")",3777,KCNK3,R-HSA-112316 Neuronal System R-HSA-1296071 Potassium Channels R-HSA-1296346 Tandem pore domain potassium channels R-HSA-1299316 TWIK-releated acid-sensitive K+ channel (TASK),cytosol GO:0005829 IEA plasma membrane GO:0005886 12198146 IMP plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 9312005 TAS,potassium ion transport TAS 9312005 GO:0006813 chemical synaptic transmission TAS 9312005 GO:0007268 brain development IEA GO:0007420 stabilization of membrane potential IBA GO:0030322 ion transmembrane transport IMP 12198146 GO:0034220 response to drug IEA GO:0042493 negative regulation of cytosolic calcium ion concentration IEA GO:0051481 cardiac conduction TAS GO:0061337 cellular response to zinc ion IEA GO:0071294 cellular response to hypoxia IEA GO:0071456 potassium ion transmembrane transport IEA GO:0071805 cochlea development IEA GO:0090102 mitophagy in response to mitochondrial depolarization IGI 22020285 GO:0098779,ion channel activity IMP 12198146 GO:0005216 open rectifier potassium channel activity IEA GO:0005252 potassium channel activity TAS GO:0005267 protein C-terminus binding IEA GO:0008022 potassium ion leak channel activity IDA 9312005 GO:0022841 protein homodimerization activity IEA GO:0042803 S100 protein binding IPI 12198146 GO:0044548 protein heterodimerization activity IEA GO:0046982,,CHEMBL CHEMBL501711,O75469,Pregnane X receptor,1.0,PRIMARY,NO,CC(C)C(=O)[C@@]12C(=O)C(=C(O)[C@@](CC=C(C)C)(C[C@H](CC=C(C)C)[C@@]1(C)CCC=C(C)C)C2=O)CC=C(C)C,2,18,"InChI=1S/C35H52O4/c1-22(2)13-12-19-33(11)27(16-14-23(3)4)21-34(20-18-25(7)8)30(37)28(17-15-24(5)6)31(38)35(33,32(34)39)29(36)26(9)10/h13-15,18,26-27,37H,12,16-17,19-21H2,1-11H3/t27-,33+,34+,35-/m0/s1",KGSZHKRKHXOAMG-HQKKAZOISA-N,"c(""Pregnane X receptor"", ""Survival motor neuron protein"", ""Microtubule-associated protein tau"", ""Histone acetyltransferase GCN5"", ""Histone-lysine N-methyltransferase, H3 lysine-9 specific 3"", ""Vitamin D receptor"", ""78 kDa glucose-regulated protein"", ""Unchecked"", ""HL-60"", ""SMMC-7721"", ""A549"", ""MCF7"", ""SW480"")",8856,NR1I2,Generic Transcription Pathway R-HSA-212436 Nuclear Receptor transcription pathway R-HSA-383280 Gene Expression R-HSA-74160,nucleoplasm GO:0005654 TAS,"GO:0006367 transcription initiation from RNA polymerase II promoter TAS GO:0006805 xenobiotic metabolic process 12578355 IDA GO:0007165 signal transduction 9784494 TAS GO:0008202 steroid metabolic process 9784494 TAS GO:0030522 intracellular receptor signaling pathway IEA GO:0042738 exogenous drug catabolic process 12578355 IDA GO:0042908 xenobiotic transport 12578355 IDA GO:0043401 steroid hormone mediated signaling pathway IEA GO:0045892 negative regulation of transcription, DNA-templated 11891224 IDA GO:0045893 positive regulation of transcription, DNA-templated 12578355 IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter 11114890 IDA GO:0046618 drug export 12578355 IDA","GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding 11114890 IDA GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding 11114890 IDA GO:0003707 steroid hormone receptor activity IEA GO:0003713 transcription coactivator activity 9727070 TAS GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding 12578355 IDA GO:0005515 protein binding 12578355 20413580 22939624 IPI GO:0008144 drug binding 12578355 IDA GO:0008270 zinc ion binding IEA",,CHEMBL CHEMBL1672547,P06401,Progesterone receptor,1.0,ORTHOGONAL,NO,CC(C)n1cc(c2ccc(C#N)c(F)c2)c3ccc(NS(=O)(=O)C)cc13,4,8,"InChI=1S/C19H18FN3O2S/c1-12(2)23-11-17(13-4-5-14(10-21)18(20)8-13)16-7-6-15(9-19(16)23)22-26(3,24)25/h4-9,11-12,22H,1-3H3",JIKFLEZNTIZKCI-UHFFFAOYSA-N,"c(""Mineralocorticoid receptor"", ""Progesterone receptor"", ""Glucocorticoid receptor"", ""Androgen Receptor"")",5241,PRGR,Generic Transcription Pathway R-HSA-212436 Nuclear Receptor transcription pathway R-HSA-383280 Gene Expression R-HSA-74160,GO:0005654 nucleoplasm TAS GO:0005741 mitochondrial outer membrane IEA,transcription initiation from RNA polymerase II promoter GO:0006367 TAS signal transduction GO:0007165 TAS 1557371 cell-cell signaling GO:0007267 TAS 1557371 negative regulation of gene expression GO:0010629 IEP 21695196 steroid hormone mediated signaling pathway GO:0043401 IEA positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA 17785366,"RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA 17785366 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 IDA 17785366 DNA binding GO:0003677 TAS 3551956 steroid hormone receptor activity GO:0003707 IEA steroid binding GO:0005496 IEA protein binding GO:0005515 IPI 12011095 12917342 17347654 20876300 21184768 zinc ion binding GO:0008270 IEA enzyme binding GO:0019899 IPI 12039952 ATPase binding GO:0051117 IDA 12058073",Oocyte meiosis - Homo sapiens (human) hsa04114 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04914,CHEMBL CHEMBL522432,P06401,Progesterone receptor,1.0,PRIMARY,NO,Cn1c(ccc1c2ccc3NC(=O)COC(C)(c4ccsc4)c3c2)C#N,5,9,"InChI=1S/C20H17N3O2S/c1-20(14-7-8-26-12-14)16-9-13(18-6-4-15(10-21)23(18)2)3-5-17(16)22-19(24)11-25-20/h3-9,12H,11H2,1-2H3,(H,22,24)",OPPYDCXBDREGJT-UHFFFAOYSA-N,"c(""Progesterone receptor"", ""Estrogen receptor alpha"", ""Androgen Receptor"", ""Glucocorticoid receptor"", ""Mineralocorticoid receptor"", ""Unchecked"")",5241,PRGR,Generic Transcription Pathway R-HSA-212436 Nuclear Receptor transcription pathway R-HSA-383280 Gene Expression R-HSA-74160,GO:0005654 nucleoplasm TAS GO:0005741 mitochondrial outer membrane IEA,transcription initiation from RNA polymerase II promoter GO:0006367 TAS signal transduction GO:0007165 TAS 1557371 cell-cell signaling GO:0007267 TAS 1557371 negative regulation of gene expression GO:0010629 IEP 21695196 steroid hormone mediated signaling pathway GO:0043401 IEA positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA 17785366,"RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA 17785366 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 IDA 17785366 DNA binding GO:0003677 TAS 3551956 steroid hormone receptor activity GO:0003707 IEA steroid binding GO:0005496 IEA protein binding GO:0005515 IPI 12011095 12917342 17347654 20876300 21184768 zinc ion binding GO:0008270 IEA enzyme binding GO:0019899 IPI 12039952 ATPase binding GO:0051117 IDA 12058073",Oocyte meiosis - Homo sapiens (human) hsa04114 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04914,CHEMBL CHEMBL117465,P06401,Progesterone receptor,1.0,ORTHOGONAL,YES,CC1=CC(C)(C)Nc2ccc(cc12)c3cc(F)cc(c3)C#N,4,24,"InChI=1S/C19H17FN2/c1-12-10-19(2,3)22-18-5-4-14(9-17(12)18)15-6-13(11-21)7-16(20)8-15/h4-10,22H,1-3H3",POQODJWQWWICOY-UHFFFAOYSA-N,"c(""Progesterone receptor"", ""Androgen Receptor"", ""Mineralocorticoid receptor"", ""Estrogen receptor"", ""Glucocorticoid receptor"")",5241,PRGR,Generic Transcription Pathway R-HSA-212436 Nuclear Receptor transcription pathway R-HSA-383280 Gene Expression R-HSA-74160,GO:0005654 nucleoplasm TAS GO:0005741 mitochondrial outer membrane IEA,transcription initiation from RNA polymerase II promoter GO:0006367 TAS signal transduction GO:0007165 TAS 1557371 cell-cell signaling GO:0007267 TAS 1557371 negative regulation of gene expression GO:0010629 IEP 21695196 steroid hormone mediated signaling pathway GO:0043401 IEA positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA 17785366,"RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA 17785366 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 IDA 17785366 DNA binding GO:0003677 TAS 3551956 steroid hormone receptor activity GO:0003707 IEA steroid binding GO:0005496 IEA protein binding GO:0005515 IPI 12011095 12917342 17347654 20876300 21184768 zinc ion binding GO:0008270 IEA enzyme binding GO:0019899 IPI 12039952 ATPase binding GO:0051117 IDA 12058073",Oocyte meiosis - Homo sapiens (human) hsa04114 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04914,CHEMBL CHEMBL1076438,P06401,Progesterone receptor,1.0,PRIMARY,YES,CC1(C)[C@H](O)CC[C@@]2(C)[C@@]1(O)CC[C@H]3Cc4c([nH]c5ccccc45)[C@]23C,6,17,"InChI=1S/C23H31NO2/c1-20(2)18(25)10-11-21(3)22(4)14(9-12-23(20,21)26)13-16-15-7-5-6-8-17(15)24-19(16)22/h5-8,14,18,24-26H,9-13H2,1-4H3/t14-,18+,21+,22+,23+/m0/s1",QJRNEHJGTLWRJJ-BVYMYZFFSA-N,"c(""Progesterone receptor"", ""Androgen Receptor"", ""Glucocorticoid receptor"", ""Mineralocorticoid receptor"", ""Estrogen receptor alpha"", ""Estrogen receptor beta"")",5241,PRGR,Generic Transcription Pathway R-HSA-212436 Nuclear Receptor transcription pathway R-HSA-383280 Gene Expression R-HSA-74160,GO:0005654 nucleoplasm TAS GO:0005741 mitochondrial outer membrane IEA,transcription initiation from RNA polymerase II promoter GO:0006367 TAS signal transduction GO:0007165 TAS 1557371 cell-cell signaling GO:0007267 TAS 1557371 negative regulation of gene expression GO:0010629 IEP 21695196 steroid hormone mediated signaling pathway GO:0043401 IEA positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA 17785366,"RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA 17785366 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001077 IDA 17785366 DNA binding GO:0003677 TAS 3551956 steroid hormone receptor activity GO:0003707 IEA steroid binding GO:0005496 IEA protein binding GO:0005515 IPI 12011095 12917342 17347654 20876300 21184768 zinc ion binding GO:0008270 IEA enzyme binding GO:0019899 IPI 12039952 ATPase binding GO:0051117 IDA 12058073",Oocyte meiosis - Homo sapiens (human) hsa04114 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04914,CHEMBL CHEMBL2159748,P48147,Prolyl endopeptidase,1.0,PRIMARY,NO,O=C(N1CCC[C@H]1C#N)c2cccc3CN(Cc4ccccc4)C(=O)c23,2,20,"InChI=1S/C21H19N3O2/c22-12-17-9-5-11-24(17)20(25)18-10-4-8-16-14-23(21(26)19(16)18)13-15-6-2-1-3-7-15/h1-4,6-8,10,17H,5,9,11,13-14H2/t17-/m0/s1",AUHQVJXPKRFCST-KRWDZBQOSA-N,"c(""Prolyl endopeptidase"", ""Fibroblast activation protein alpha"")",5550,PPCE,,nucleus IEA GO:0005634 cytoplasm IDA GO:0005737 membrane IDA 19946888 GO:0016020,IEA GO:0006508 proteolysis,IEA GO:0004252 serine-type endopeptidase activity IPI 23348613 protein binding GO:0005515 TAS 7959018 serine-type peptidase activity GO:0008236 IEA GO:0070008 serine-type exopeptidase activity,Renin-angiotensin system - Homo sapiens (human) hsa04614,CHEMBL CHEMBL3342849,O14684,Prostaglandin E synthase,1.0,PRIMARY,NO,CC(C)C(=O)NCc1ccc(Cl)c(c1)C2=Nc3cc(ncc3C(=O)N2)c4ccc(cc4)C(F)(F)F,10,21,"InChI=1S/C25H20ClF3N4O2/c1-13(2)23(34)31-11-14-3-8-19(26)17(9-14)22-32-21-10-20(30-12-18(21)24(35)33-22)15-4-6-16(7-5-15)25(27,28)29/h3-10,12-13H,11H2,1-2H3,(H,31,34)(H,32,33,35)",SXZOHBBSSIEDDY-UHFFFAOYSA-N,"c(""Prostaglandin E synthase"", ""Cyclooxygenase-1"", ""Cyclooxygenase-2"", ""Prostaglandin E synthase 2"", ""Prostaglandin E synthase 3"", ""Hematopoietic prostaglandin D synthase"", ""Thromboxane-A synthase"", ""Prostaglandin I2 synthase"", ""Prostanoid FP receptor"", ""Cytosolic phospholipase A2"", ""Unchecked"")",9536,PTGES,Metabolism R-HSA-1430728 Arachidonic acid metabolism R-HSA-2142753 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) R-HSA-2162123 Metabolism of lipids and lipoproteins R-HSA-556833,GO:0005641 nuclear envelope lumen IEA GO:0005789 endoplasmic reticulum membrane TAS GO:0016020 membrane 10377395 TAS GO:0016021 integral component of membrane 18682561 IDA GO:0048471 perinuclear region of cytoplasm IEA,18682561 IDA GO:0001516 prostaglandin biosynthetic process IEA GO:0002526 acute inflammatory response IEA GO:0002544 chronic inflammatory response 10377395 TAS GO:0006693 prostaglandin metabolic process 10377395 NAS GO:0007165 signal transduction IEA GO:0008285 negative regulation of cell proliferation IEA GO:0014070 response to organic cyclic compound TAS GO:0019371 cyclooxygenase pathway IEA GO:0032496 response to lipopolysaccharide IEA GO:0032526 response to retinoic acid IEA GO:0034097 response to cytokine IEA GO:0051592 response to calcium ion,18682561 IDA GO:0043295 glutathione binding 18682561 EXP GO:0050220 prostaglandin-E synthase activity 18682561 IDA GO:0050220 prostaglandin-E synthase activity,hsa00590 Arachidonic acid metabolism - Homo sapiens (human),CHEMBL CHEMBL383484,Q13258,Prostanoid DP receptor,1.0,ORTHOGONAL,NO,CC(=O)c1cc(cc2c3CC[C@H](CC(=O)O)c3n(Cc4ccc(Cl)cc4)c12)S(=O)(=O)C,8,25,"InChI=1S/C23H22ClNO5S/c1-13(26)19-10-17(31(2,29)30)11-20-18-8-5-15(9-21(27)28)22(18)25(23(19)20)12-14-3-6-16(24)7-4-14/h3-4,6-7,10-11,15H,5,8-9,12H2,1-2H3,(H,27,28)/t15-/m1/s1",YYVOCPXSWUYWAL-OAHLLOKOSA-N,"c(""Prostanoid DP receptor"", ""Thromboxane A2 receptor"", ""Prostanoid EP1 receptor"", ""Prostanoid EP2 receptor"", ""Prostanoid EP3 receptor"", ""Prostanoid EP4 receptor"", ""Prostanoid FP receptor"", ""Prostanoid IP receptor"", ""Unchecked"")",5729,PD2R,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signaling R-HSA-391903 Eicosanoid ligand-binding receptors R-HSA-391908 Prostanoid ligand receptors R-HSA-418555 G alpha (s) signalling events R-HSA-500792 GPCR ligand binding,plasma membrane GO:0005886 IDA 20959461 plasma membrane GO:0005886 TAS integral component of membrane GO:0016021 NAS 7642548,inflammatory response GO:0006954 IEA G-protein coupled receptor signaling pathway GO:0007186 7642548 NAS male sex determination GO:0030238 IEA sleep GO:0030431 IEA adenosine metabolic process GO:0046085 IEA cellular response to prostaglandin D stimulus GO:0071799 IEA,prostaglandin J receptor activity GO:0001785 IEA prostaglandin D receptor activity GO:0004956 7642548 NAS protein binding GO:0005515 20959461 IPI,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL483991,Q13258,Prostanoid DP receptor,1.0,PRIMARY,NO,CC(C)c1nccc2c1c(Sc3ccc(Cl)c(Cl)c3)c4[C@@H](CC(=O)O)CCn24,9,12,"InChI=1S/C21H20Cl2N2O2S/c1-11(2)19-18-16(5-7-24-19)25-8-6-12(9-17(26)27)20(25)21(18)28-13-3-4-14(22)15(23)10-13/h3-5,7,10-12H,6,8-9H2,1-2H3,(H,26,27)/t12-/m1/s1",LUZBJNWFEDHIPR-GFCCVEGCSA-N,"c(""Prostanoid DP receptor"", ""Thromboxane A2 receptor"", ""Prostanoid EP1 receptor"", ""Prostanoid EP2 receptor"", ""Prostanoid EP3 receptor"", ""Prostanoid EP4 receptor"", ""Prostanoid FP receptor"", ""Prostanoid IP receptor"", ""G protein-coupled receptor 44"")",5729,PD2R,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signaling R-HSA-391903 Eicosanoid ligand-binding receptors R-HSA-391908 Prostanoid ligand receptors R-HSA-418555 G alpha (s) signalling events R-HSA-500792 GPCR ligand binding,plasma membrane GO:0005886 IDA 20959461 plasma membrane GO:0005886 TAS integral component of membrane GO:0016021 NAS 7642548,inflammatory response GO:0006954 IEA G-protein coupled receptor signaling pathway GO:0007186 7642548 NAS male sex determination GO:0030238 IEA sleep GO:0030431 IEA adenosine metabolic process GO:0046085 IEA cellular response to prostaglandin D stimulus GO:0071799 IEA,prostaglandin J receptor activity GO:0001785 IEA prostaglandin D receptor activity GO:0004956 7642548 NAS protein binding GO:0005515 20959461 IPI,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL3127163,P34995,Prostanoid EP1 receptor,1.0,PRIMARY,NO,OC(=O)c1csc(n1)n2nc(c3ccccc3)c4ccc(cc24)C(F)(F)F,6,8,"InChI=1S/C18H10F3N3O2S/c19-18(20,21)11-6-7-12-14(8-11)24(17-22-13(9-27-17)16(25)26)23-15(12)10-4-2-1-3-5-10/h1-9H,(H,25,26)",JELFUQAHMVGHOB-UHFFFAOYSA-N,"c(""Adenosine A3 receptor"", ""Adenosine A1 receptor"", ""Prostanoid EP4 receptor"", ""Prostanoid EP3 receptor"", ""Prostanoid EP2 receptor"", ""Prostanoid EP1 receptor"")",5731,PE2R1,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signaling R-HSA-391903 Eicosanoid ligand-binding receptors R-HSA-391908 Prostanoid ligand receptors R-HSA-416476 G alpha (q) signalling events R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,TAS GO:0005886 plasma membrane TAS 8253813 integral component of plasma membrane GO:0005887,G-protein coupled receptor signaling pathway GO:0007186 IEA response to lipopolysaccharide GO:0032496 IEA,prostaglandin E receptor activity GO:0004957 IEA,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human),CHEMBL CHEMBL64246,P43116,Prostanoid EP2 receptor,1.0,ORTHOGONAL,NO,CCC1(CCC1)[C@@H](O)C\C=C\[C@H]2[C@H](O)C[C@@H](Cl)[C@@H]2C\C=C/CCCC(=O)O,5,8,"InChI=1S/C22H35ClO4/c1-2-22(13-8-14-22)20(25)11-7-10-17-16(18(23)15-19(17)24)9-5-3-4-6-12-21(26)27/h3,5,7,10,16-20,24-25H,2,4,6,8-9,11-15H2,1H3,(H,26,27)/b5-3-,10-7+/t16-,17-,18-,19-,20+/m1/s1",LBIPUBVVGYRBNA-VGUVCEGPSA-N,"c(""Prostanoid EP2 receptor"", ""Prostanoid IP receptor"", ""Prostanoid EP1 receptor"", ""Prostanoid EP3 receptor"", ""Prostanoid EP4 receptor"")",5732,PE2R2,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 Eicosanoid ligand-binding receptors R-HSA-391903 Prostanoid ligand receptors R-HSA-391908 G alpha (s) signalling events R-HSA-418555 GPCR ligand binding R-HSA-500792,TAS GO:0005886 plasma membrane 10462542 TAS GO:0005887 integral component of plasma membrane,10462542 GO:0007186 G-protein coupled receptor signaling pathway TAS GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway ISS GO:0032496 response to lipopolysaccharide IEA GO:0032570 response to progesterone IEA GO:0042127 regulation of cell proliferation IEA GO:0071380 cellular response to prostaglandin E stimulus ISS,GO:0004957 prostaglandin E receptor activity IEA,hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04924 Renin secretion - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human),CHEMBL CHEMBL3586360,P43116,Prostanoid EP2 receptor,1.0,PRIMARY,NO,Fc1ccc2c(ccn2c3cc(Cl)c4OCCN(CC5=CC(=O)NC=C5)Cc4c3)c1,8,14,"InChI=1S/C23H19ClFN3O2/c24-20-12-19(28-6-4-16-10-18(25)1-2-21(16)28)11-17-14-27(7-8-30-23(17)20)13-15-3-5-26-22(29)9-15/h1-6,9-12H,7-8,13-14H2,(H,26,29)",JCMBXRJQNVPHIQ-UHFFFAOYSA-N,"c(""Unchecked"", ""G protein-coupled receptor 44"", ""Thromboxane A2 receptor"", ""Prostanoid IP receptor"", ""Prostanoid DP receptor"", ""Prostanoid EP2 receptor"", ""Prostanoid EP3 receptor"", ""Prostanoid EP4 receptor"", ""Prostanoid EP1 receptor"")",5732,PE2R2,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 Eicosanoid ligand-binding receptors R-HSA-391903 Prostanoid ligand receptors R-HSA-391908 G alpha (s) signalling events R-HSA-418555 GPCR ligand binding R-HSA-500792,TAS GO:0005886 plasma membrane 10462542 TAS GO:0005887 integral component of plasma membrane,10462542 GO:0007186 G-protein coupled receptor signaling pathway TAS GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway ISS GO:0032496 response to lipopolysaccharide IEA GO:0032570 response to progesterone IEA GO:0042127 regulation of cell proliferation IEA GO:0071380 cellular response to prostaglandin E stimulus ISS,GO:0004957 prostaglandin E receptor activity IEA,hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04924 Renin secretion - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human),CHEMBL CHEMBL217941,P43115,Prostanoid EP3 receptor,1.0,ORTHOGONAL,NO,COc1ccc(Br)cc1S(=O)(=O)NC(=O)\C=C\c2ccccc2Cc3ccc4cc(OCc5ccccc5)ccc4c3,8,10,"InChI=1S/C34H28BrNO5S/c1-40-32-17-15-30(35)22-33(32)42(38,39)36-34(37)18-14-26-9-5-6-10-27(26)19-25-11-12-29-21-31(16-13-28(29)20-25)41-23-24-7-3-2-4-8-24/h2-18,20-22H,19,23H2,1H3,(H,36,37)/b18-14+",VDVWBLTUVKUGOI-NBVRZTHBSA-N,"c(""Prostanoid EP1 receptor"", ""Prostanoid EP2 receptor"", ""Prostanoid EP3 receptor"", ""Prostanoid EP4 receptor"", ""Prostanoid IP receptor"", ""Thromboxane A2 receptor"", ""Prostanoid FP receptor"", ""Prostanoid DP receptor"")",5733,PE2R3,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signaling R-HSA-391903 Eicosanoid ligand-binding receptors R-HSA-391908 Prostanoid ligand receptors R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,nuclear envelope GO:0005635 10336471 TAS plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 8307176 TAS cell surface GO:0009986 IEA integral component of membrane GO:0016021 9073510 NAS brush border membrane GO:0031526 IEA nuclear membrane GO:0031965 IEA neuronal cell body GO:0043025 IEA proximal neuron projection GO:1990769 IEA,"transcription, DNA-templated TAS 10336471 GO:0006351 G-protein coupled receptor signaling pathway IEA GO:0007186 positive regulation of cytosolic calcium ion concentration IEA GO:0007204 female pregnancy IEA GO:0007565 cell death TAS 10947062 GO:0008219 positive regulation of gene expression IEA GO:0010628 negative regulation of norepinephrine secretion IEA GO:0010700 intestine smooth muscle contraction IEA GO:0014827 urinary bladder smooth muscle contraction IEA GO:0014832 intracellular receptor signaling pathway IEA GO:0030522 negative regulation of cAMP biosynthetic process IEA GO:0030818 positive regulation of cAMP biosynthetic process IEA GO:0030819 positive regulation of fever generation ISS GO:0031622 response to estradiol IEA GO:0032355 response to progesterone IEA GO:0032570 response to drug IEA GO:0042493 positive regulation of vasoconstriction IEA GO:0045907 positive regulation of circadian sleep/wake cycle, non-REM sleep IEA GO:0046010 negative regulation of insulin secretion IEA GO:0046676 maternal process involved in parturition IEA GO:0060137 cellular response to lipopolysaccharide IEA GO:0071222 cellular response to interleukin-1 IEA GO:0071347 negative regulation of platelet aggregation IEA GO:0090331 negative regulation of potassium ion transmembrane transport IEA GO:1901380 response to salt IEA GO:1902074 negative regulation of calcium ion transmembrane transport IEA GO:1903170 negative regulation of gastrin-induced gastric acid secretion IEA GO:1903640 positive regulation of smooth muscle contraction involved in micturition IEA GO:1904320 cellular response to forskolin IEA GO:1904322 positive regulation of inhibitory G-protein coupled receptor phosphorylation IEA GO:1904325 negative regulation of circadian sleep/wake cycle, wakefulness IEA GO:1904326 positive regulation of myofibroblast contraction IEA GO:1904330 positive regulation of colon smooth muscle contraction IEA GO:1904343 positive regulation of gastric mucosal blood circulation IEA GO:1904346 prostaglandin receptor internalization IEA GO:1990767 positive regulation of neutrophil extravasation IEA GO:2000391 negative regulation of forebrain neuron differentiation IEA GO:2000978","RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding TAS 10336471 GO:0004879 prostaglandin E receptor activity NAS 9073510 GO:0004957",Calcium signaling pathway - Homo sapiens (human) hsa04020 cAMP signaling pathway - Homo sapiens (human) hsa04024 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04923 Pathways in cancer - Homo sapiens (human) hsa05200,CHEMBL CHEMBL220802,P43115,Prostanoid EP3 receptor,1.0,PRIMARY,NO,O=C(NS(=O)(=O)c1cccs1)\C=C\c2ccccc2Cc3ccc4ccccc4c3,8,12,"InChI=1S/C24H19NO3S2/c26-23(25-30(27,28)24-10-5-15-29-24)14-13-20-7-2-4-9-22(20)17-18-11-12-19-6-1-3-8-21(19)16-18/h1-16H,17H2,(H,25,26)/b14-13+",MOOPBYUCHZCDPA-BUHFOSPRSA-N,"c(""Prostanoid EP1 receptor"", ""Prostanoid EP2 receptor"", ""Prostanoid EP3 receptor"", ""Prostanoid EP4 receptor"", ""Prostanoid IP receptor"", ""Thromboxane A2 receptor"", ""Prostanoid FP receptor"", ""Prostanoid DP receptor"")",5733,PE2R3,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signaling R-HSA-391903 Eicosanoid ligand-binding receptors R-HSA-391908 Prostanoid ligand receptors R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,nuclear envelope GO:0005635 10336471 TAS plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 8307176 TAS cell surface GO:0009986 IEA integral component of membrane GO:0016021 9073510 NAS brush border membrane GO:0031526 IEA nuclear membrane GO:0031965 IEA neuronal cell body GO:0043025 IEA proximal neuron projection GO:1990769 IEA,"transcription, DNA-templated TAS 10336471 GO:0006351 G-protein coupled receptor signaling pathway IEA GO:0007186 positive regulation of cytosolic calcium ion concentration IEA GO:0007204 female pregnancy IEA GO:0007565 cell death TAS 10947062 GO:0008219 positive regulation of gene expression IEA GO:0010628 negative regulation of norepinephrine secretion IEA GO:0010700 intestine smooth muscle contraction IEA GO:0014827 urinary bladder smooth muscle contraction IEA GO:0014832 intracellular receptor signaling pathway IEA GO:0030522 negative regulation of cAMP biosynthetic process IEA GO:0030818 positive regulation of cAMP biosynthetic process IEA GO:0030819 positive regulation of fever generation ISS GO:0031622 response to estradiol IEA GO:0032355 response to progesterone IEA GO:0032570 response to drug IEA GO:0042493 positive regulation of vasoconstriction IEA GO:0045907 positive regulation of circadian sleep/wake cycle, non-REM sleep IEA GO:0046010 negative regulation of insulin secretion IEA GO:0046676 maternal process involved in parturition IEA GO:0060137 cellular response to lipopolysaccharide IEA GO:0071222 cellular response to interleukin-1 IEA GO:0071347 negative regulation of platelet aggregation IEA GO:0090331 negative regulation of potassium ion transmembrane transport IEA GO:1901380 response to salt IEA GO:1902074 negative regulation of calcium ion transmembrane transport IEA GO:1903170 negative regulation of gastrin-induced gastric acid secretion IEA GO:1903640 positive regulation of smooth muscle contraction involved in micturition IEA GO:1904320 cellular response to forskolin IEA GO:1904322 positive regulation of inhibitory G-protein coupled receptor phosphorylation IEA GO:1904325 negative regulation of circadian sleep/wake cycle, wakefulness IEA GO:1904326 positive regulation of myofibroblast contraction IEA GO:1904330 positive regulation of colon smooth muscle contraction IEA GO:1904343 positive regulation of gastric mucosal blood circulation IEA GO:1904346 prostaglandin receptor internalization IEA GO:1990767 positive regulation of neutrophil extravasation IEA GO:2000391 negative regulation of forebrain neuron differentiation IEA GO:2000978","RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding TAS 10336471 GO:0004879 prostaglandin E receptor activity NAS 9073510 GO:0004957",Calcium signaling pathway - Homo sapiens (human) hsa04020 cAMP signaling pathway - Homo sapiens (human) hsa04024 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Regulation of lipolysis in adipocytes - Homo sapiens (human) hsa04923 Pathways in cancer - Homo sapiens (human) hsa05200,CHEMBL CHEMBL597997,P35408,Prostanoid EP4 receptor,1.0,ORTHOGONAL,NO,Cc1sc(C)c(C(=O)NC2(CC2)c3ccc(cc3)C(=O)O)c1Cc4ccc(cc4)C(F)(F)F,9,22,"InChI=1S/C25H22F3NO3S/c1-14-20(13-16-3-7-19(8-4-16)25(26,27)28)21(15(2)33-14)22(30)29-24(11-12-24)18-9-5-17(6-10-18)23(31)32/h3-10H,11-13H2,1-2H3,(H,29,30)(H,31,32)",QJZQFVRFJCGDKF-UHFFFAOYSA-N,"c(""Prostanoid EP4 receptor"", ""Prostanoid EP2 receptor"", ""Prostanoid EP1 receptor"", ""Prostanoid EP3 receptor"", ""Prostanoid DP receptor"", ""G protein-coupled receptor 44"", ""Prostanoid IP receptor"", ""Thromboxane A2 receptor"", ""Prostanoid FP receptor"", ""Unchecked"")",5734,PE2R4,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 Eicosanoid ligand-binding receptors R-HSA-391903 Prostanoid ligand receptors R-HSA-391908 G alpha (s) signalling events R-HSA-418555 GPCR ligand binding R-HSA-500792,plasma membrane GO:0005886 TAS integral component of membrane 8163486 GO:0016021 NAS nuclear membrane GO:0031965 IEA neuronal cell body GO:0043025 IEA neuron projection terminus GO:0044306 IEA,"GO:0002792 negative regulation of peptide secretion IEA GO:0006955 immune response 8862514 IEP GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway 8163486 IDA GO:0007254 JNK cascade ISS GO:0007565 female pregnancy IEA GO:0008284 positive regulation of cell proliferation IEA GO:0009612 response to mechanical stimulus 21723865 IEP GO:0010628 positive regulation of gene expression IEA GO:0010727 negative regulation of hydrogen peroxide metabolic process IEA GO:0010840 regulation of circadian sleep/wake cycle, wakefulness IEA GO:0014911 positive regulation of smooth muscle cell migration IEA GO:0030819 positive regulation of cAMP biosynthetic process IEA GO:0032496 response to lipopolysaccharide IEA GO:0032570 response to progesterone IEA GO:0032757 positive regulation of interleukin-8 production IEA GO:0033624 negative regulation of integrin activation 21681739 IDA GO:0035810 positive regulation of urine volume IEA GO:0035815 positive regulation of renal sodium excretion IEA GO:0042093 T-helper cell differentiation ISS GO:0042322 negative regulation of circadian sleep/wake cycle, REM sleep IEA GO:0042466 chemokinesis IEA GO:0042493 response to drug IEA GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein IEA GO:0043200 response to amino acid IEA GO:0045669 positive regulation of osteoblast differentiation IEA GO:0045780 positive regulation of bone resorption IEA GO:0045785 positive regulation of cell adhesion IEA GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep IEA GO:0050710 negative regulation of cytokine secretion ISS GO:0050712 negative regulation of interleukin-1 alpha secretion IEA GO:0050715 positive regulation of cytokine secretion ISS GO:0050728 negative regulation of inflammatory response 16424369 IDA GO:0050729 positive regulation of inflammatory response ISS GO:0051492 regulation of stress fiber assembly ISS GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process IEA GO:0060137 maternal process involved in parturition IEA GO:0060348 bone development ISS GO:0070257 positive regulation of mucus secretion IEA GO:0070371 ERK1 and ERK2 cascade ISS GO:0071260 cellular response to mechanical stimulus ISS GO:0071333 cellular response to glucose stimulus IEA GO:0071347 cellular response to interleukin-1 IEA GO:0071380 cellular response to prostaglandin E stimulus IEA GO:0090303 positive regulation of wound healing IEA GO:0097070 ductus arteriosus closure IEA GO:1900127 positive regulation of hyaluronan biosynthetic process IEA GO:1902074 response to salt IEA GO:1904336 negative regulation of ductus arteriosus closure IEA GO:1904348 negative regulation of small intestine smooth muscle contraction IEA GO:1904364 positive regulation of calcitonin secretion IEA GO:1904367 positive regulation of chemokinesis IEA GO:1904466 positive regulation of matrix metallopeptidase secretion IEA GO:1904468 negative regulation of tumor necrosis factor secretion IEA GO:1904471 negative regulation of endothelin secretion IEA GO:1904496 positive regulation of substance P secretion, neurotransmission IEA GO:1990785 response to water-immersion restraint stress IEA GO:2000388 positive regulation of antral ovarian follicle growth IEA GO:2000391 positive regulation of neutrophil extravasation IEA GO:2000420 negative regulation of eosinophil extravasation 21681739 IDA GO:2001181 positive regulation of interleukin-10 secretion IEA",GO:0004957 prostaglandin E receptor activity 8163486 IDA GO:0005515 protein binding 16424369 IPI,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04924 Renin secretion - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human),CHEMBL CHEMBL3115074,P35408,Prostanoid EP4 receptor,1.0,PRIMARY,NO,Cl.C[C@H](NC(=O)[C@H]1CCCCN1CCOc2ccccc2)c3ccc(cc3)C(=O)O,12,24,"InChI=1S/C23H28N2O4.ClH/c1-17(18-10-12-19(13-11-18)23(27)28)24-22(26)21-9-5-6-14-25(21)15-16-29-20-7-3-2-4-8-20;/h2-4,7-8,10-13,17,21H,5-6,9,14-16H2,1H3,(H,24,26)(H,27,28);1H/t17-,21+;/m0./s1",FMJSLPJYTAKVLJ-CQVJSGDESA-N,"c(""Prostanoid EP4 receptor"", ""Prostanoid EP3 receptor"", ""Prostanoid EP2 receptor"", ""Prostanoid EP1 receptor"", ""Beta-2 adrenergic receptor"", ""Beta-1 adrenergic receptor"", ""Unchecked"", ""Dopamine D2 receptor"", ""Histamine H1 receptor"", ""Muscarinic acetylcholine receptor M3"", ""Mu opioid receptor"", ""Serotonin 2b (5-HT2b) receptor"", ""Voltage-gated L-type calcium channel"", ""Norepinephrine transporter"")",5734,PE2R4,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 Eicosanoid ligand-binding receptors R-HSA-391903 Prostanoid ligand receptors R-HSA-391908 G alpha (s) signalling events R-HSA-418555 GPCR ligand binding R-HSA-500792,plasma membrane GO:0005886 TAS integral component of membrane 8163486 GO:0016021 NAS nuclear membrane GO:0031965 IEA neuronal cell body GO:0043025 IEA neuron projection terminus GO:0044306 IEA,"GO:0002792 negative regulation of peptide secretion IEA GO:0006955 immune response 8862514 IEP GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway 8163486 IDA GO:0007254 JNK cascade ISS GO:0007565 female pregnancy IEA GO:0008284 positive regulation of cell proliferation IEA GO:0009612 response to mechanical stimulus 21723865 IEP GO:0010628 positive regulation of gene expression IEA GO:0010727 negative regulation of hydrogen peroxide metabolic process IEA GO:0010840 regulation of circadian sleep/wake cycle, wakefulness IEA GO:0014911 positive regulation of smooth muscle cell migration IEA GO:0030819 positive regulation of cAMP biosynthetic process IEA GO:0032496 response to lipopolysaccharide IEA GO:0032570 response to progesterone IEA GO:0032757 positive regulation of interleukin-8 production IEA GO:0033624 negative regulation of integrin activation 21681739 IDA GO:0035810 positive regulation of urine volume IEA GO:0035815 positive regulation of renal sodium excretion IEA GO:0042093 T-helper cell differentiation ISS GO:0042322 negative regulation of circadian sleep/wake cycle, REM sleep IEA GO:0042466 chemokinesis IEA GO:0042493 response to drug IEA GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein IEA GO:0043200 response to amino acid IEA GO:0045669 positive regulation of osteoblast differentiation IEA GO:0045780 positive regulation of bone resorption IEA GO:0045785 positive regulation of cell adhesion IEA GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep IEA GO:0050710 negative regulation of cytokine secretion ISS GO:0050712 negative regulation of interleukin-1 alpha secretion IEA GO:0050715 positive regulation of cytokine secretion ISS GO:0050728 negative regulation of inflammatory response 16424369 IDA GO:0050729 positive regulation of inflammatory response ISS GO:0051492 regulation of stress fiber assembly ISS GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process IEA GO:0060137 maternal process involved in parturition IEA GO:0060348 bone development ISS GO:0070257 positive regulation of mucus secretion IEA GO:0070371 ERK1 and ERK2 cascade ISS GO:0071260 cellular response to mechanical stimulus ISS GO:0071333 cellular response to glucose stimulus IEA GO:0071347 cellular response to interleukin-1 IEA GO:0071380 cellular response to prostaglandin E stimulus IEA GO:0090303 positive regulation of wound healing IEA GO:0097070 ductus arteriosus closure IEA GO:1900127 positive regulation of hyaluronan biosynthetic process IEA GO:1902074 response to salt IEA GO:1904336 negative regulation of ductus arteriosus closure IEA GO:1904348 negative regulation of small intestine smooth muscle contraction IEA GO:1904364 positive regulation of calcitonin secretion IEA GO:1904367 positive regulation of chemokinesis IEA GO:1904466 positive regulation of matrix metallopeptidase secretion IEA GO:1904468 negative regulation of tumor necrosis factor secretion IEA GO:1904471 negative regulation of endothelin secretion IEA GO:1904496 positive regulation of substance P secretion, neurotransmission IEA GO:1990785 response to water-immersion restraint stress IEA GO:2000388 positive regulation of antral ovarian follicle growth IEA GO:2000391 positive regulation of neutrophil extravasation IEA GO:2000420 negative regulation of eosinophil extravasation 21681739 IDA GO:2001181 positive regulation of interleukin-10 secretion IEA",GO:0004957 prostaglandin E receptor activity 8163486 IDA GO:0005515 protein binding 16424369 IPI,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04924 Renin secretion - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human),CHEMBL CHEMBL37853,P43088,Prostanoid FP receptor,1.0,ORTHOGONAL,NO,O[C@@H](COc1cccc(Cl)c1)\C=C\[C@H]2[C@H](O)C[C@H](O)[C@@H]2C\C=C/CCCC(=O)O,8,17,"InChI=1S/C22H29ClO6/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1",VJGGHXVGBSZVMZ-QIZQQNKQSA-N,"c(""Prostanoid FP receptor"", ""Prostanoid EP1 receptor"", ""Prostanoid EP2 receptor"", ""Prostanoid EP3 receptor"", ""Prostanoid EP4 receptor"", ""Thromboxane A2 receptor"", ""Prostanoid DP receptor"", ""Prostanoid IP receptor"", ""Unchecked"", ""Thyroid hormone receptor beta-1"")",5737,PF2R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 Eicosanoid ligand-binding receptors R-HSA-391903 Prostanoid ligand receptors R-HSA-391908 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,10575000 GO:0005576 extracellular region IDA 18508192 GO:0005737 cytoplasm IDA 18508192 GO:0005886 plasma membrane IDA GO:0005886 plasma membrane TAS 8300593 GO:0005887 integral component of plasma membrane TAS,G-protein coupled receptor signaling pathway GO:0007186 IEA parturition GO:0007567 TAS 9918852 positive regulation of cell proliferation GO:0008284 IMP 18508192 positive regulation of gene expression GO:0010628 IEA response to estradiol GO:0032355 IEA response to lipopolysaccharide GO:0032496 IEA calcium-mediated signaling using intracellular calcium source GO:0035584 IDA 18587449 negative regulation of apoptotic process GO:0043066 IEA cellular response to prostaglandin D stimulus GO:0071799 IMP 18508192,prostaglandin F receptor activity GO:0004958 IDA 18587449,Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL815,P43088,Prostanoid FP receptor,1.0,PRIMARY,NO,CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(=O)O,8,53,"InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1",PXGPLTODNUVGFL-YNNPMVKQSA-N,"c(""Homo sapiens"", ""Prostanoid FP receptor"", ""Prostanoid EP1 receptor"", ""Prostanoid EP2 receptor"", ""Prostanoid EP3 receptor"", ""Prostanoid EP4 receptor"", ""Thromboxane A2 receptor"", ""Prostanoid DP receptor"", ""Prostanoid IP receptor"", ""Unchecked"", ""Prelamin-A/C"", ""Solute carrier family 22 member 2"", ""Solute carrier family 22 member 7"", ""Solute carrier family 22 member 1"", ""Solute carrier family 22 member 6"", ""Solute carrier family 22 member 11"", ""Solute carrier family 22 member 8"", ""Multidrug resistance-associated protein 4"", ""Multidrug resistance-associated protein 5"", ""Solute carrier organic anion transporter family member 2A1"", ""Androgen Receptor"")",5737,PF2R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 Eicosanoid ligand-binding receptors R-HSA-391903 Prostanoid ligand receptors R-HSA-391908 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,10575000 GO:0005576 extracellular region IDA 18508192 GO:0005737 cytoplasm IDA 18508192 GO:0005886 plasma membrane IDA GO:0005886 plasma membrane TAS 8300593 GO:0005887 integral component of plasma membrane TAS,G-protein coupled receptor signaling pathway GO:0007186 IEA parturition GO:0007567 TAS 9918852 positive regulation of cell proliferation GO:0008284 IMP 18508192 positive regulation of gene expression GO:0010628 IEA response to estradiol GO:0032355 IEA response to lipopolysaccharide GO:0032496 IEA calcium-mediated signaling using intracellular calcium source GO:0035584 IDA 18587449 negative regulation of apoptotic process GO:0043066 IEA cellular response to prostaglandin D stimulus GO:0071799 IMP 18508192,prostaglandin F receptor activity GO:0004958 IDA 18587449,Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL2326261,P49721,Proteasome Macropain subunit,1.0,PRIMARY,NO,CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(CN)cc1)NC(=O)[C@H](Cc2ccccc2)N=[N+]=[N-])C(=O)N[C@@H](Cc3ccc(CN)cc3)\C=C\S(=O)(=O)C,3,20,"InChI=1S/C37H48N8O5S/c1-25(2)19-32(35(46)41-31(17-18-51(3,49)50)20-27-9-13-29(23-38)14-10-27)42-36(47)33(21-28-11-15-30(24-39)16-12-28)43-37(48)34(44-45-40)22-26-7-5-4-6-8-26/h4-18,25,31-34H,19-24,38-39H2,1-3H3,(H,41,46)(H,42,47)(H,43,48)/b18-17+/t31-,32+,33+,34+/m1/s1",VSAACOMACMBQKJ-YWIYQGBMSA-N,"c(""Proteasome component C5"", ""Proteasome Macropain subunit MB1"", ""Proteasome Macropain subunit"", ""Unchecked"")",5690,PSB2,,proteasome complex IDA 17323924 GO:0000502 nucleus IDA 21630459 GO:0005634 nucleoplasm IDA GO:0005654 nucleoplasm TAS GO:0005654 cytosol TAS GO:0005829 proteasome core complex ISS GO:0005839 membrane IDA 19946888 GO:0016020 extracellular exosome IDA 19056867 20458337 23376485 23533145 GO:0070062,"TAS GO:0000165 MAPK cascade TAS GO:0000209 protein polyubiquitination TAS GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS GO:0006521 regulation of cellular amino acid metabolic process IEA GO:0010243 response to organonitrogen compound IEA GO:0014070 response to organic cyclic compound IEA GO:0016032 viral process TAS GO:0031145 anaphase-promoting complex-dependent catabolic process TAS GO:0033209 tumor necrosis factor-mediated signaling pathway TAS GO:0038061 NIK/NF-kappaB signaling TAS GO:0038095 Fc-epsilon receptor signaling pathway TAS GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS GO:0043488 regulation of mRNA stability TAS GO:0050852 T cell receptor signaling pathway TAS GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS GO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS GO:0090090 negative regulation of canonical Wnt signaling pathway TAS GO:0090263 positive regulation of canonical Wnt signaling pathway",IEA GO:0004298 threonine-type endopeptidase activity IPI 14733938 17948026 25416956 protein binding GO:0005515,Proteasome - Homo sapiens (human) hsa03050,CHEMBL CHEMBL207990,P28074,Proteasome Macropain subunit MB1,1.0,PRIMARY,NO,CC[C@H](C)[C@H](NC(=O)[C@H]([C@@H](C)CC)N(C)C(=O)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1,4,40,"InChI=1S/C28H50N4O7/c1-11-16(5)21(30-27(38)23(17(6)12-2)32(10)19(8)34)25(36)31-22(18(7)33)26(37)29-20(13-15(3)4)24(35)28(9)14-39-28/h15-18,20-23,33H,11-14H2,1-10H3,(H,29,37)(H,30,38)(H,31,36)/t16-,17-,18+,20-,21-,22-,23-,28+/m0/s1",DOGIDQKFVLKMLQ-JTHVHQAWSA-N,"c(""Proteasome"", ""Unchecked"", ""Proteasome Macropain subunit MB1"", ""Proteasome Macropain subunit"", ""Proteasome component C5"", ""Cathepsin S"", ""PC-3"")",5693,PSB5,,GO:0000502 proteasome complex 17323924 IDA GO:0005634 nucleus 21630459 IDA GO:0005654 nucleoplasm IDA GO:0005654 nucleoplasm TAS GO:0005813 centrosome IDA GO:0005829 cytosol TAS GO:0005839 proteasome core complex ISS GO:0070062 extracellular exosome 19056867 23376485 IDA,"TAS GO:0000165 MAPK cascade TAS GO:0000209 protein polyubiquitination TAS GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent 17540904 IDA GO:0006508 proteolysis TAS GO:0006521 regulation of cellular amino acid metabolic process IEA GO:0006979 response to oxidative stress IEA GO:0016032 viral process TAS GO:0031145 anaphase-promoting complex-dependent catabolic process TAS GO:0033209 tumor necrosis factor-mediated signaling pathway TAS GO:0038061 NIK/NF-kappaB signaling TAS GO:0038095 Fc-epsilon receptor signaling pathway TAS GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS GO:0043488 regulation of mRNA stability TAS GO:0050852 T cell receptor signaling pathway TAS GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS GO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS GO:0090090 negative regulation of canonical Wnt signaling pathway TAS GO:0090263 positive regulation of canonical Wnt signaling pathway",IEA GO:0004298 threonine-type endopeptidase activity 14733938 17948026 20723761 IPI GO:0005515 protein binding 17540904 IDA GO:0008233 peptidase activity,hsa03050 Proteasome - Homo sapiens (human),CHEMBL CHEMBL3319482,P28062,Proteasome subunit beta type-8,1.0,ORTHOGONAL,NO,C[C@@H](NC(=O)C1=C(C)c2ccccc2C1)C(=O)N[C@@H](Cc3c[nH]c4ccccc34)C(=O)N[C@@H](Cc5ccccc5)C(=O)[C@@]6(C)CO6,3,20,"InChI=1S/C37H38N4O5/c1-22-27-14-8-7-13-25(27)18-29(22)35(44)39-23(2)34(43)41-32(19-26-20-38-30-16-10-9-15-28(26)30)36(45)40-31(33(42)37(3)21-46-37)17-24-11-5-4-6-12-24/h4-16,20,23,31-32,38H,17-19,21H2,1-3H3,(H,39,44)(H,40,45)(H,41,43)/t23-,31+,32+,37-/m1/s1",ADBUEVSHEJICCM-LZNHGOJSSA-N,"c(""Proteasome subunit beta type-8"", ""Unchecked"", ""Proteasome subunit beta type-9"", ""Proteasome subunit beta type-10"")",5696,PSB8,,proteasome complex GO:0000502 IDA 26524591 nucleoplasm GO:0005654 TAS cytosol GO:0005829 TAS proteasome core complex GO:0005839 ISS extracellular exosome GO:0070062 IDA 20458337 23376485 spermatoproteasome complex GO:1990111 ISS,"MAPK cascade GO:0000165 TAS protein polyubiquitination GO:0000209 TAS stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 TAS regulation of cellular amino acid metabolic process GO:0006521 TAS viral process GO:0016032 IEA anaphase-promoting complex-dependent catabolic process GO:0031145 TAS tumor necrosis factor-mediated signaling pathway GO:0033209 TAS NIK/NF-kappaB signaling GO:0038061 TAS Fc-epsilon receptor signaling pathway GO:0038095 TAS proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 TAS regulation of mRNA stability GO:0043488 TAS fat cell differentiation GO:0045444 21881205 IMP T cell receptor signaling pathway GO:0050852 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051436 TAS positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0051437 TAS regulation of endopeptidase activity GO:0052548 26524591 IMP Wnt signaling pathway, planar cell polarity pathway GO:0060071 TAS type I interferon signaling pathway GO:0060337 TAS negative regulation of canonical Wnt signaling pathway GO:0090090 TAS positive regulation of canonical Wnt signaling pathway GO:0090263 TAS",threonine-type endopeptidase activity GO:0004298 IEA protein binding GO:0005515 15303969 IPI,Proteasome - Homo sapiens (human) hsa03050,CHEMBL CHEMBL3237875,P28062,Proteasome subunit beta type-8,1.0,PRIMARY,NO,COc1ccc(C[C@H](NC(=O)[C@H](C)NC(=O)CN2CCOCC2)C(=O)N[C@@H](Cc3ccccc3)C(=O)[C@@]4(C)CO4)cc1,4,22,"InChI=1S/C31H40N4O7/c1-21(32-27(36)19-35-13-15-41-16-14-35)29(38)34-26(18-23-9-11-24(40-3)12-10-23)30(39)33-25(28(37)31(2)20-42-31)17-22-7-5-4-6-8-22/h4-12,21,25-26H,13-20H2,1-3H3,(H,32,36)(H,33,39)(H,34,38)/t21-,25-,26-,31+/m0/s1",WQAVPPWWLLVGFK-VTNASVEKSA-N,"c(""Proteasome Macropain subunit MB1"", ""Proteasome subunit beta type-8"", ""Unchecked"", ""Proteasome subunit beta type-9"", ""Proteasome subunit beta type-10"")",5696,PSB8,,proteasome complex GO:0000502 IDA 26524591 nucleoplasm GO:0005654 TAS cytosol GO:0005829 TAS proteasome core complex GO:0005839 ISS extracellular exosome GO:0070062 IDA 20458337 23376485 spermatoproteasome complex GO:1990111 ISS,"MAPK cascade GO:0000165 TAS protein polyubiquitination GO:0000209 TAS stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 TAS regulation of cellular amino acid metabolic process GO:0006521 TAS viral process GO:0016032 IEA anaphase-promoting complex-dependent catabolic process GO:0031145 TAS tumor necrosis factor-mediated signaling pathway GO:0033209 TAS NIK/NF-kappaB signaling GO:0038061 TAS Fc-epsilon receptor signaling pathway GO:0038095 TAS proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 TAS regulation of mRNA stability GO:0043488 TAS fat cell differentiation GO:0045444 21881205 IMP T cell receptor signaling pathway GO:0050852 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051436 TAS positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0051437 TAS regulation of endopeptidase activity GO:0052548 26524591 IMP Wnt signaling pathway, planar cell polarity pathway GO:0060071 TAS type I interferon signaling pathway GO:0060337 TAS negative regulation of canonical Wnt signaling pathway GO:0090090 TAS positive regulation of canonical Wnt signaling pathway GO:0090263 TAS",threonine-type endopeptidase activity GO:0004298 IEA protein binding GO:0005515 15303969 IPI,Proteasome - Homo sapiens (human) hsa03050,CHEMBL CHEMBL3319604,P28065,Proteasome subunit beta type-9,1.0,PRIMARY,NO,CCCC[C@H](NC(=O)[C@@H]1CC(F)(F)CN1C(=O)[C@H](C)NC(=O)CN=[N+]=[N-])C(=O)N[C@@H](CC2CCCCC2)C(=O)[C@@]3(C)CO3,2,11,"InChI=1S/C28H43F2N7O6/c1-4-5-11-19(24(40)35-20(23(39)27(3)16-43-27)12-18-9-7-6-8-10-18)34-25(41)21-13-28(29,30)15-37(21)26(42)17(2)33-22(38)14-32-36-31/h17-21H,4-16H2,1-3H3,(H,33,38)(H,34,41)(H,35,40)/t17-,19-,20-,21-,27+/m0/s1",BYGWQGGWZMNGGA-MDEFBCHOSA-N,"c(""Proteasome subunit beta type-9"", ""Unchecked"", ""Proteasome subunit beta type-10"")",5698,PSB9,,TAS 8666937 proteasome complex GO:0000502 TAS GO:0005654 nucleoplasm IDA GO:0005737 cytoplasm TAS GO:0005829 cytosol ISS GO:0005839 proteasome core complex IDA 20458337 extracellular exosome GO:0070062 ISS GO:1990111 spermatoproteasome complex,"MAPK cascade GO:0000165 TAS protein polyubiquitination GO:0000209 TAS liver development GO:0001889 IEA stimulatory C-type lectin receptor signaling pathway GO:0002223 TAS antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent GO:0002479 TAS regulation of cellular amino acid metabolic process GO:0006521 TAS muscle atrophy GO:0014889 IEA viral process GO:0016032 IEA anaphase-promoting complex-dependent catabolic process GO:0031145 TAS tumor necrosis factor-mediated signaling pathway GO:0033209 TAS NIK/NF-kappaB signaling GO:0038061 TAS Fc-epsilon receptor signaling pathway GO:0038095 TAS response to drug GO:0042493 IEA proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043161 TAS response to alkaloid GO:0043279 IEA regulation of mRNA stability GO:0043488 TAS spleen development GO:0048536 IEA thymus development GO:0048538 IEA T cell receptor signaling pathway GO:0050852 TAS negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051436 TAS positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0051437 TAS Wnt signaling pathway, planar cell polarity pathway GO:0060071 TAS cellular response to electrical stimulus GO:0071257 IEA cellular response to interleukin-1 GO:0071347 IEA negative regulation of canonical Wnt signaling pathway GO:0090090 TAS positive regulation of canonical Wnt signaling pathway GO:0090263 TAS cellular response to virus GO:0098586 IEA response to benzene GO:1901423 IEA regulation of cysteine-type endopeptidase activity 26524591 GO:2000116 IMP",threonine-type endopeptidase activity GO:0004298 IEA protein binding 14733938 16957778 18985028 20723761 GO:0005515 IPI proteasome binding GO:0070628 IEA,hsa03050 Proteasome - Homo sapiens (human),CHEMBL CHEMBL360304,P05771,Protein kinase C beta,1.0,PRIMARY,NO,CN(C)CCCn1nc(C2=C(C(=O)NC2=O)c3cn(c4cccc5ccccc45)c6ccccc36)c7ccccc17,6,14,"InChI=1S/C34H29N5O2/c1-37(2)19-10-20-39-29-17-8-6-15-25(29)32(36-39)31-30(33(40)35-34(31)41)26-21-38(28-16-7-5-14-24(26)28)27-18-9-12-22-11-3-4-13-23(22)27/h3-9,11-18,21H,10,19-20H2,1-2H3,(H,35,40,41)",IGFXNXIRVKBKLL-UHFFFAOYSA-N,"c(""Glycogen synthase kinase-3 beta"", ""Unchecked"", ""Protein kinase C beta"", ""Protein kinase C alpha"", ""Protein kinase C gamma"", ""Protein kinase C delta"", ""Protein kinase C zeta"")",5579,KPCB,"Hemostasis R-HSA-109582 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-112314 Transmission across Chemical Synapses R-HSA-112315 Neuronal System R-HSA-112316 Disinhibition of SNARE formation R-HSA-114516 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1168372 Activation of NF-kappaB in B cells R-HSA-1169091 Adaptive Immune System R-HSA-1280218 Signal Transduction R-HSA-162582 Cell Cycle R-HSA-1640170 Immune System R-HSA-168256 Signaling by VEGF R-HSA-194138 Signaling by Wnt R-HSA-195721 Nuclear Envelope Breakdown R-HSA-2980766 Signaling by GPCR R-HSA-372790 beta-catenin independent WNT signaling R-HSA-3858494 GPCR downstream signaling R-HSA-388396 Trafficking of AMPA receptors R-HSA-399719 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity R-HSA-399721 PCP/CE pathway R-HSA-4086400 Trafficking of GluR2-containing AMPA receptors R-HSA-416993 G alpha (z) signalling events R-HSA-418597 Depolymerisation of the Nuclear Lamina R-HSA-4419969 VEGFA-VEGFR2 Pathway R-HSA-4420097 WNT5A-dependent internalization of FZD4 R-HSA-5099900 VEGFR2 mediated cell proliferation R-HSA-5218921 Mitotic Prophase R-HSA-68875 M Phase R-HSA-68886 Cell Cycle, Mitotic R-HSA-69278 Platelet activation, signaling and aggregation R-HSA-76002 Response to elevated platelet cytosolic Ca2+ R-HSA-76005 Signaling by the B Cell Receptor (BCR) R-HSA-983705",20228790 IDA GO:0005634 nucleus TAS GO:0005654 nucleoplasm 15632189 IDA GO:0005737 cytoplasm TAS GO:0005829 cytosol 15632189 IDA GO:0005886 plasma membrane TAS GO:0005886 plasma membrane 20458337 IDA GO:0070062 extracellular exosome,"GO:0001666 response to hypoxia IEA GO:0002250 adaptive immune response IEA GO:0006351 transcription, DNA-templated IEA 20228790 GO:0006357 regulation of transcription from RNA polymerase II promoter IMP 3755548 GO:0006468 protein phosphorylation TAS GO:0006816 calcium ion transport IEA GO:0006874 cellular calcium ion homeostasis IEA GO:0006915 apoptotic process IEA GO:0007077 mitotic nuclear envelope disassembly TAS 3755548 GO:0007165 signal transduction NAS GO:0010829 negative regulation of glucose transport ISS GO:0018105 peptidyl-serine phosphorylation IBA GO:0030168 platelet activation TAS GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway ISS 20228790 GO:0035408 histone H3-T6 phosphorylation IDA GO:0035556 intracellular signal transduction IBA GO:0042113 B cell activation ISS 18981301 GO:0042953 lipoprotein transport TAS GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling ISS GO:0045766 positive regulation of angiogenesis ISS GO:0046627 negative regulation of insulin receptor signaling pathway ISS GO:0050853 B cell receptor signaling pathway ISS GO:0050861 positive regulation of B cell receptor signaling pathway ISS GO:0051092 positive regulation of NF-kappaB transcription factor activity ISS GO:0071322 cellular response to carbohydrate stimulus IEA",20228790 GO:0003682 chromatin binding IDA 12391145 GO:0004674 protein serine/threonine kinase activity EXP GO:0004674 protein serine/threonine kinase activity TAS GO:0004697 protein kinase C activity TAS GO:0004698 calcium-dependent protein kinase C activity TAS 20228790 GO:0005080 protein kinase C binding IPI GO:0005246 calcium channel regulator activity IEA 20228790 21044950 25852190 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0008270 zinc ion binding IEA 20228790 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IMP 20228790 GO:0035403 histone kinase activity (H3-T6 specific) IDA 20228790 GO:0042393 histone binding IDA 20228790 GO:0050681 androgen receptor binding IDA,hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04064 NF-kappa B signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human) hsa04071 Sphingolipid signaling pathway - Homo sapiens (human) hsa04150 mTOR signaling pathway - Homo sapiens (human) hsa04270 Vascular smooth muscle contraction - Homo sapiens (human) hsa04310 Wnt signaling pathway - Homo sapiens (human) hsa04370 VEGF signaling pathway - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04530 Tight junction - Homo sapiens (human) hsa04540 Gap junction - Homo sapiens (human) hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human) hsa04662 B cell receptor signaling pathway - Homo sapiens (human) hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human) hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04670 Leukocyte transendothelial migration - Homo sapiens (human) hsa04713 Circadian entrainment - Homo sapiens (human) hsa04720 Long-term potentiation - Homo sapiens (human) hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human) hsa04724 Glutamatergic synapse - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human) hsa04726 Serotonergic synapse - Homo sapiens (human) hsa04727 GABAergic synapse - Homo sapiens (human) hsa04728 Dopaminergic synapse - Homo sapiens (human) hsa04730 Long-term depression - Homo sapiens (human) hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04911 Insulin secretion - Homo sapiens (human) hsa04912 GnRH signaling pathway - Homo sapiens (human) hsa04916 Melanogenesis - Homo sapiens (human) hsa04918 Thyroid hormone synthesis - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04921 Oxytocin signaling pathway - Homo sapiens (human) hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human) hsa04961 Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) hsa04970 Salivary secretion - Homo sapiens (human) hsa04971 Gastric acid secretion - Homo sapiens (human) hsa04972 Pancreatic secretion - Homo sapiens (human) hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human) hsa05031 Amphetamine addiction - Homo sapiens (human) hsa05032 Morphine addiction - Homo sapiens (human) hsa05110 Vibrio cholerae infection - Homo sapiens (human) hsa05140 Leishmaniasis - Homo sapiens (human) hsa05143 African trypanosomiasis - Homo sapiens (human) hsa05146 Amoebiasis - Homo sapiens (human) hsa05161 Hepatitis B - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05214 Glioma - Homo sapiens (human) hsa05223 Non-small cell lung cancer - Homo sapiens (human) hsa05231 Choline metabolism in cancer - Homo sapiens (human),CHEMBL CHEMBL2393448,Q05513,Protein kinase C zeta,1.0,ORTHOGONAL,NO,CCOC(=O)c1c(N)scc1c2ccc(cc2)N(C)C,2,7,"InChI=1S/C15H18N2O2S/c1-4-19-15(18)13-12(9-20-14(13)16)10-5-7-11(8-6-10)17(2)3/h5-9H,4,16H2,1-3H3",YAZWNGDLKIJVLM-UHFFFAOYSA-N,"c(""Protein kinase C iota"", ""Protein kinase C zeta"", ""Unchecked"")",5590,KPCZ,"R-HSA-109582 Hemostasis R-HSA-114604 GPVI-mediated activation cascade R-HSA-162582 Signal Transduction R-HSA-170834 Signaling by TGF-beta Receptor Complex R-HSA-194138 Signaling by VEGF R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-76002 Platelet activation, signaling and aggregation",nuclear envelope GO:0005635 IEA cytoplasm GO:0005737 7925449 TAS endosome GO:0005768 IEA microtubule organizing center GO:0005815 IEA cytosol GO:0005829 TAS plasma membrane GO:0005886 7925449 TAS cell-cell junction GO:0005911 20332120 IDA bicellular tight junction GO:0005923 IEA membrane GO:0016020 7925449 TAS apical plasma membrane GO:0016324 IEA nuclear matrix GO:0016363 IEA cell junction GO:0030054 TAS cell leading edge GO:0031252 IEA filamentous actin GO:0031941 IEA vesicle GO:0031982 17313651 IDA myelin sheath abaxonal region GO:0035748 IEA axon hillock GO:0043203 IEA membrane raft GO:0045121 IEA apical cortex GO:0045179 IEA perinuclear region of cytoplasm GO:0048471 IEA extracellular exosome GO:0070062 19056867 IDA,microtubule cytoskeleton organization IEA GO:0000226 positive regulation of cell-matrix adhesion IEA GO:0001954 protein phosphorylation IDA 10770950 17313651 GO:0006468 inflammatory response IEA GO:0006954 signal transduction TAS 8224878 GO:0007165 transforming growth factor beta receptor signaling pathway TAS GO:0007179 long-term memory IEA GO:0007616 positive regulation of cell proliferation IEA GO:0008284 insulin receptor signaling pathway IEA GO:0008286 cell migration IEA GO:0016477 peptidyl-serine phosphorylation IDA 15069075 GO:0018105 establishment of cell polarity ISS GO:0030010 negative regulation of protein complex assembly IMP 15069075 GO:0031333 actin cytoskeleton reorganization IEA GO:0031532 activation of phospholipase D activity IEA GO:0031584 activation of protein kinase B activity IEA GO:0032148 positive regulation of interleukin-4 production ISS GO:0032753 negative regulation of apoptotic process IEA GO:0043066 positive regulation of T-helper 2 cell differentiation ISS GO:0045630 positive regulation of glucose import IEA GO:0046326 negative regulation of insulin receptor signaling pathway IMP 15069075 GO:0046627 positive regulation of insulin receptor signaling pathway ISS GO:0046628 vesicle transport along microtubule IEA GO:0047496 negative regulation of peptidyl-tyrosine phosphorylation IMP 15069075 GO:0050732 positive regulation of NF-kappaB transcription factor activity ISS GO:0051092 protein heterooligomerization IEA GO:0051291 negative regulation of hydrolase activity IEA GO:0051346 membrane depolarization IEA GO:0051899 membrane hyperpolarization IEA GO:0060081 long-term synaptic potentiation ISS GO:0060291 positive regulation of ERK1 and ERK2 cascade IMP 11035106 GO:0070374 protein kinase C signaling IEA GO:0070528 protein localization to plasma membrane IEA GO:0072659 neuron projection extension IEA GO:1990138 positive regulation of excitatory postsynaptic potential ISS GO:2000463 positive regulation of T-helper 2 cell cytokine production ISS GO:2000553 positive regulation of interleukin-5 secretion ISS GO:2000664 positive regulation of interleukin-13 secretion ISS GO:2000667 positive regulation of interleukin-10 secretion ISS GO:2001181,protein kinase activity IDA 10770950 GO:0004672 protein serine/threonine kinase activity EXP 12391145 GO:0004674 protein serine/threonine kinase activity IDA 15069075 GO:0004674 protein kinase C activity TAS GO:0004697 protein binding IPI 10831594 11260256 11755531 12893243 14676191 15707389 16189514 16792529 17057644 17203073 17313651 17350623 17588663 18190796 18650932 22939624 24375676 25011391 25241761 25852190 GO:0005515 ATP binding IEA GO:0005524 potassium channel regulator activity IEA GO:0015459 protein kinase binding IEA GO:0019901 protein domain specific binding IEA GO:0019904 phospholipase binding IEA GO:0043274 insulin receptor substrate binding IC 15069075 GO:0043560 metal ion binding IEA GO:0046872 14-3-3 protein binding IEA GO:0071889,Rap1 signaling pathway - Homo sapiens (human) hsa04015 Chemokine signaling pathway - Homo sapiens (human) hsa04062 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 Endocytosis - Homo sapiens (human) hsa04144 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Hippo signaling pathway - Homo sapiens (human) hsa04390 Tight junction - Homo sapiens (human) hsa04530 Platelet activation - Homo sapiens (human) hsa04611 Insulin signaling pathway - Homo sapiens (human) hsa04910 Type II diabetes mellitus - Homo sapiens (human) hsa04930,CHEMBL CHEMBL2393423,Q05513,Protein kinase C zeta,1.0,PRIMARY,NO,COc1ccc(cc1OC)c2csc(N)c2C(=O)OC(C)C,2,8,"InChI=1S/C16H19NO4S/c1-9(2)21-16(18)14-11(8-22-15(14)17)10-5-6-12(19-3)13(7-10)20-4/h5-9H,17H2,1-4H3",WEHPOCNINSGWET-UHFFFAOYSA-N,"c(""Protein kinase C iota"", ""Protein kinase C zeta"", ""Unchecked"")",5590,KPCZ,"R-HSA-109582 Hemostasis R-HSA-114604 GPVI-mediated activation cascade R-HSA-162582 Signal Transduction R-HSA-170834 Signaling by TGF-beta Receptor Complex R-HSA-194138 Signaling by VEGF R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-76002 Platelet activation, signaling and aggregation",nuclear envelope GO:0005635 IEA cytoplasm GO:0005737 7925449 TAS endosome GO:0005768 IEA microtubule organizing center GO:0005815 IEA cytosol GO:0005829 TAS plasma membrane GO:0005886 7925449 TAS cell-cell junction GO:0005911 20332120 IDA bicellular tight junction GO:0005923 IEA membrane GO:0016020 7925449 TAS apical plasma membrane GO:0016324 IEA nuclear matrix GO:0016363 IEA cell junction GO:0030054 TAS cell leading edge GO:0031252 IEA filamentous actin GO:0031941 IEA vesicle GO:0031982 17313651 IDA myelin sheath abaxonal region GO:0035748 IEA axon hillock GO:0043203 IEA membrane raft GO:0045121 IEA apical cortex GO:0045179 IEA perinuclear region of cytoplasm GO:0048471 IEA extracellular exosome GO:0070062 19056867 IDA,microtubule cytoskeleton organization IEA GO:0000226 positive regulation of cell-matrix adhesion IEA GO:0001954 protein phosphorylation IDA 10770950 17313651 GO:0006468 inflammatory response IEA GO:0006954 signal transduction TAS 8224878 GO:0007165 transforming growth factor beta receptor signaling pathway TAS GO:0007179 long-term memory IEA GO:0007616 positive regulation of cell proliferation IEA GO:0008284 insulin receptor signaling pathway IEA GO:0008286 cell migration IEA GO:0016477 peptidyl-serine phosphorylation IDA 15069075 GO:0018105 establishment of cell polarity ISS GO:0030010 negative regulation of protein complex assembly IMP 15069075 GO:0031333 actin cytoskeleton reorganization IEA GO:0031532 activation of phospholipase D activity IEA GO:0031584 activation of protein kinase B activity IEA GO:0032148 positive regulation of interleukin-4 production ISS GO:0032753 negative regulation of apoptotic process IEA GO:0043066 positive regulation of T-helper 2 cell differentiation ISS GO:0045630 positive regulation of glucose import IEA GO:0046326 negative regulation of insulin receptor signaling pathway IMP 15069075 GO:0046627 positive regulation of insulin receptor signaling pathway ISS GO:0046628 vesicle transport along microtubule IEA GO:0047496 negative regulation of peptidyl-tyrosine phosphorylation IMP 15069075 GO:0050732 positive regulation of NF-kappaB transcription factor activity ISS GO:0051092 protein heterooligomerization IEA GO:0051291 negative regulation of hydrolase activity IEA GO:0051346 membrane depolarization IEA GO:0051899 membrane hyperpolarization IEA GO:0060081 long-term synaptic potentiation ISS GO:0060291 positive regulation of ERK1 and ERK2 cascade IMP 11035106 GO:0070374 protein kinase C signaling IEA GO:0070528 protein localization to plasma membrane IEA GO:0072659 neuron projection extension IEA GO:1990138 positive regulation of excitatory postsynaptic potential ISS GO:2000463 positive regulation of T-helper 2 cell cytokine production ISS GO:2000553 positive regulation of interleukin-5 secretion ISS GO:2000664 positive regulation of interleukin-13 secretion ISS GO:2000667 positive regulation of interleukin-10 secretion ISS GO:2001181,protein kinase activity IDA 10770950 GO:0004672 protein serine/threonine kinase activity EXP 12391145 GO:0004674 protein serine/threonine kinase activity IDA 15069075 GO:0004674 protein kinase C activity TAS GO:0004697 protein binding IPI 10831594 11260256 11755531 12893243 14676191 15707389 16189514 16792529 17057644 17203073 17313651 17350623 17588663 18190796 18650932 22939624 24375676 25011391 25241761 25852190 GO:0005515 ATP binding IEA GO:0005524 potassium channel regulator activity IEA GO:0015459 protein kinase binding IEA GO:0019901 protein domain specific binding IEA GO:0019904 phospholipase binding IEA GO:0043274 insulin receptor substrate binding IC 15069075 GO:0043560 metal ion binding IEA GO:0046872 14-3-3 protein binding IEA GO:0071889,Rap1 signaling pathway - Homo sapiens (human) hsa04015 Chemokine signaling pathway - Homo sapiens (human) hsa04062 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 Endocytosis - Homo sapiens (human) hsa04144 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Hippo signaling pathway - Homo sapiens (human) hsa04390 Tight junction - Homo sapiens (human) hsa04530 Platelet activation - Homo sapiens (human) hsa04611 Insulin signaling pathway - Homo sapiens (human) hsa04910 Type II diabetes mellitus - Homo sapiens (human) hsa04930,CHEMBL CHEMBL3408213,P56704,Protein Wnt-3a,1.0,PRIMARY,NO,Cn1cc(cn1)c2ccc(cc2)c3cncc(Cl)c3N4CCC5(CCNC5=O)CC4,5,14,"InChI=1S/C23H24ClN5O/c1-28-15-18(12-27-28)16-2-4-17(5-3-16)19-13-25-14-20(24)21(19)29-10-7-23(8-11-29)6-9-26-22(23)30/h2-5,12-15H,6-11H2,1H3,(H,26,30)",LBFYQISQYCGDDW-UHFFFAOYSA-N,"c(""Unchecked"", ""Tankyrase-1"", ""Tankyrase-2"", ""Glycogen synthase kinase-3 alpha"", ""Glycogen synthase kinase-3 beta"", ""Protein Wnt-3a"")",89780,WNT3A,Signal Transduction R-HSA-162582 Signaling by Wnt R-HSA-195721 TCF dependent signaling in response to WNT R-HSA-201681 WNT ligand biogenesis and trafficking R-HSA-3238698 Signaling by GPCR R-HSA-372790 Class B/2 (Secretin family receptors) R-HSA-373080 negative regulation of TCF-dependent signaling by WNT ligand antagonists R-HSA-3772470 disassembly of the destruction complex and recruitment of AXIN to the membrane R-HSA-4641262 regulation of FZD by ubiquitination R-HSA-4641263 GPCR ligand binding R-HSA-500792,extracellular region GO:0005576 TAS proteinaceous extracellular matrix GO:0005578 IEA extracellular space GO:0005615 IBA extracellular space GO:0005615 ISS endoplasmic reticulum lumen GO:0005788 TAS Golgi lumen GO:0005796 TAS cytosol GO:0005829 IEA plasma membrane GO:0005886 TAS cell surface GO:0009986 ISS endocytic vesicle membrane GO:0030666 TAS early endosome membrane GO:0031901 TAS extracellular exosome GO:0070062 TAS presynapse GO:0098793 IEA Wnt-Frizzled-LRP5/6 complex 20093360 GO:1990851 IDA,"GO:0001649 osteoblast differentiation IEA GO:0001701 in utero embryonic development IEA GO:0001819 positive regulation of cytokine production IEA GO:0001934 positive regulation of protein phosphorylation 20137080 20412773 IDA GO:0001947 heart looping IEA GO:0002092 positive regulation of receptor internalization 16890161 IDA GO:0003136 negative regulation of heart induction by canonical Wnt signaling pathway 19736317 IDA GO:0007411 axon guidance IEA GO:0007416 synapse assembly 24449494 TAS GO:0008284 positive regulation of cell proliferation ISS GO:0010387 COP9 signalosome assembly ISS GO:0010977 negative regulation of neuron projection development ISS GO:0016055 Wnt signaling pathway TAS GO:0021527 spinal cord association neuron differentiation IEA GO:0021766 hippocampus development IEA GO:0021846 cell proliferation in forebrain ISS GO:0021874 Wnt signaling pathway involved in forebrain neuroblast division IEA GO:0021904 dorsal/ventral neural tube patterning IEA GO:0030097 hemopoiesis IEA GO:0030182 neuron differentiation ISS GO:0030198 extracellular matrix organization IEA GO:0030879 mammary gland development IEA GO:0030890 positive regulation of B cell proliferation IEA GO:0032092 positive regulation of protein binding 16890161 IDA GO:0033138 positive regulation of peptidyl-serine phosphorylation 20723538 IDA GO:0033278 cell proliferation in midbrain 24431302 TAS GO:0034613 cellular protein localization IEA GO:0035413 positive regulation of catenin import into nucleus 20137080 20723538 IDA GO:0035914 skeletal muscle cell differentiation IEA GO:0036342 post-anal tail morphogenesis IEA GO:0036465 synaptic vesicle recycling 22988876 TAS GO:0042472 inner ear morphogenesis IEA GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA GO:0045599 negative regulation of fat cell differentiation IEA GO:0045893 positive regulation of transcription, DNA-templated ISS GO:0045944 positive regulation of transcription from RNA polymerase II promoter 20723538 IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS GO:0048337 positive regulation of mesodermal cell fate specification 20559569 IDA GO:0048343 paraxial mesodermal cell fate commitment IEA GO:0048643 positive regulation of skeletal muscle tissue development IEA GO:0048697 positive regulation of collateral sprouting in absence of injury IEA GO:0048843 negative regulation of axon extension involved in axon guidance IEA GO:0050768 negative regulation of neurogenesis ISS GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IEA GO:0060021 palate development 18413325 IMP GO:0060070 canonical Wnt signaling pathway 19101069 20137080 20723538 IDA GO:0061098 positive regulation of protein tyrosine kinase activity IEA GO:0061184 positive regulation of dermatome development 10654605 IDA GO:0061317 canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment 20559569 IDA GO:0070507 regulation of microtubule cytoskeleton organization IEA GO:0070527 platelet aggregation IEA GO:0071300 cellular response to retinoic acid ISS GO:0090245 axis elongation involved in somitogenesis IEA GO:0090263 positive regulation of canonical Wnt signaling pathway 17976063 18941195 IDA GO:1903078 positive regulation of protein localization to plasma membrane IEA GO:1904339 negative regulation of dopaminergic neuron differentiation IEA GO:1904886 beta-catenin destruction complex disassembly TAS GO:1904953 Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation 22988876 TAS GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin IEA GO:2000081 positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation IEA GO:2000179 positive regulation of neural precursor cell proliferation IEA GO:2000347 positive regulation of hepatocyte proliferation IEA GO:2000679 positive regulation of transcription regulatory region DNA binding IEA GO:2000727 positive regulation of cardiac muscle cell differentiation 20559569 IDA",GO:0003713 transcription coactivator activity ISS GO:0005102 receptor binding 20093360 IPI GO:0005109 frizzled binding IBA GO:0005110 frizzled-2 binding IEA GO:0005515 protein binding 19072540 22682250 24768165 IPI GO:0019904 protein domain specific binding IEA GO:0039706 co-receptor binding 20093360 IPI GO:0048018 receptor agonist activity 20723538 IDA,hsa04310 Wnt signaling pathway - Homo sapiens (human) hsa04340 Hedgehog signaling pathway - Homo sapiens (human) hsa04390 Hippo signaling pathway - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04916 Melanogenesis - Homo sapiens (human) hsa05166 HTLV-I infection - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05217 Basal cell carcinoma - Homo sapiens (human),CHEMBL CHEMBL605580,Q96NT5,Proton-coupled folate transporter,1.0,PRIMARY,NO,NC1=Nc2[nH]c(CCCCCc3ccc(s3)C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc2C(=O)N1,4,17,"InChI=1S/C21H25N5O6S/c22-21-25-17-13(18(29)26-21)10-11(23-17)4-2-1-3-5-12-6-8-15(33-12)19(30)24-14(20(31)32)7-9-16(27)28/h6,8,10,14H,1-5,7,9H2,(H,24,30)(H,27,28)(H,31,32)(H4,22,23,25,26,29)/t14-/m0/s1",NDMAMOPJTVHRPP-AWEZNQCLSA-N,"c(""Unchecked"", ""R2"", ""KB"", ""IGROV-1"", ""Proton-coupled folate transporter"", ""GAR transformylase"", ""Folate receptor alpha"", ""Folate receptor beta"")",113235,PCFT,Metabolism R-HSA-1430728 Metabolism of folate and pterines R-HSA-196757 Metabolism of water-soluble vitamins and cofactors R-HSA-196849 Metabolism of vitamins and cofactors R-HSA-196854 Transmembrane transport of small molecules R-HSA-382551 Iron uptake and transport R-HSA-917937,GO:0005737 cytoplasm ISS 17129779 GO:0005886 plasma membrane IDA GO:0005886 plasma membrane TAS 19581412 GO:0009986 cell surface IDA GO:0016021 integral component of membrane IEA 17475902 19762432 GO:0016324 apical plasma membrane IDA GO:0031526 brush border membrane IEA,cellular iron ion homeostasis GO:0006879 TAS folic acid transport GO:0015884 IDA 17129779 17475902 19762432 folic acid transport GO:0015884 IMP 17129779 heme transport GO:0015886 IEA folic acid metabolic process GO:0046655 TAS methotrexate transport GO:0051958 IDA 19762432 methotrexate transport GO:0051958 IMP 17129779 intestinal folate absorption GO:0098829 IC 19762432 hydrogen ion transmembrane transport GO:1902600 IDA 17129779 folic acid import into cell GO:1904447 IDA 19762432,folic acid binding GO:0005542 IEA folic acid transporter activity GO:0008517 IDA 17129779 17475902 folic acid transporter activity GO:0008517 IMP 19762432 folic acid transporter activity GO:0008517 TAS hydrogen ion transmembrane transporter activity GO:0015078 IDA 17129779 heme transporter activity GO:0015232 NOT IDA 17129779 heme transporter activity GO:0015232 TAS methotrexate transporter activity GO:0015350 IC 19762432,Vitamin digestion and absorption - Homo sapiens (human) hsa04977 Mineral absorption - Homo sapiens (human) hsa04978,CHEMBL CHEMBL3093756,Q12866,Proto-oncogene tyrosine-protein kinase MER,1.0,PRIMARY,NO,CCCCNc1ncc(C(=O)NCc2ccc(cc2)n3ccnc3)c(N[C@@H]4CC[C@@H](O)CC4)n1,3,7,"InChI=1S/C25H33N7O2/c1-2-3-12-27-25-29-16-22(23(31-25)30-19-6-10-21(33)11-7-19)24(34)28-15-18-4-8-20(9-5-18)32-14-13-26-17-32/h4-5,8-9,13-14,16-17,19,21,33H,2-3,6-7,10-12,15H2,1H3,(H,28,34)(H2,27,29,30,31)/t19-,21-",NPVXOWLPOFYACO-XUTJKUGGSA-N,"c(""Plasma"", ""Proto-oncogene tyrosine-protein kinase MER"", ""Tyrosine-protein kinase receptor TYRO3"", ""Tyrosine-protein kinase receptor UFO"", ""Unchecked"")",10461,MERTK,R-HSA-109582 Hemostasis R-HSA-202733 Cell surface interactions at the vascular wall,photoreceptor outer segment IEA GO:0001750 extracellular space IDA 18395422 GO:0005615 cytoplasm IDA 18395422 19204785 GO:0005737 plasma membrane TAS GO:0005886 integral component of plasma membrane TAS 8086340 GO:0005887 rhabdomere IDA 19204785 GO:0016028,IEA GO:0001779 natural killer cell differentiation TAS 8086340 protein phosphorylation GO:0006468 IMP 19204785 phagocytosis GO:0006909 TAS 8086340 cell surface receptor signaling pathway GO:0007166 TAS 8086340 cell-cell signaling GO:0007267 IEA GO:0007283 spermatogenesis IEA GO:0018108 peptidyl-tyrosine phosphorylation IEA GO:0030168 platelet activation IEA GO:0032940 secretion by cell IEA GO:0034446 substrate adhesion-dependent cell spreading IEA GO:0043277 apoptotic cell clearance IEA GO:0043491 protein kinase B signaling IDA 18395422 positive regulation of phagocytosis GO:0050766 TAS GO:0050900 leukocyte migration IEA GO:0051250 negative regulation of lymphocyte activation IEA GO:0060041 retina development in camera-type eye IEA GO:0060068 vagina development IMP 23353780 negative regulation of leukocyte apoptotic process GO:2000107,IEA GO:0004714 transmembrane receptor protein tyrosine kinase activity IPI 20103767 protein binding GO:0005515 IEA GO:0005524 ATP binding,,CHEMBL CHEMBL2333767,P47900,Purinergic receptor P2Y1,1.0,ORTHOGONAL,NO,Cc1ccc(NC(=O)Nc2cccnc2Sc3ccccc3C(C)(C)C)cc1,6,7,"InChI=1S/C23H25N3OS/c1-16-11-13-17(14-12-16)25-22(27)26-19-9-7-15-24-21(19)28-20-10-6-5-8-18(20)23(2,3)4/h5-15H,1-4H3,(H2,25,26,27)",VZYJPMFMCIMJOD-UHFFFAOYSA-N,"c(""Purinergic receptor P2Y14"", ""Purinergic receptor P2Y11"", ""Pyrimidinergic receptor P2Y6"", ""Purinergic receptor P2Y2"", ""Unchecked"", ""Purinergic receptor P2Y12"", ""Purinergic receptor P2Y1"")",5028,P2RY1,"Hemostasis R-HSA-109582 Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 Signal amplification R-HSA-392518 G alpha (q) signalling events R-HSA-416476 P2Y receptors R-HSA-417957 Nucleotide-like (purinergic) receptors R-HSA-418038 ADP signalling through P2Y purinoceptor 1 R-HSA-418592 GPCR ligand binding R-HSA-500792 Platelet activation, signaling and aggregation R-HSA-76002 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907",GO:0005739 mitochondrion IEA GO:0005829 cytosol IEA GO:0005886 plasma membrane ISS GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 8630005 TAS GO:0009986 cell surface 23382103 IDA GO:0016323 basolateral plasma membrane IEA GO:0016324 apical plasma membrane IEA GO:0030425 dendrite ISS GO:0044297 cell body ISS GO:0045211 postsynaptic membrane ISS,ISS GO:0001934 positive regulation of protein phosphorylation IEA GO:0001973 adenosine receptor signaling pathway 8630005 TAS GO:0007166 cell surface receptor signaling pathway ISS GO:0007186 G-protein coupled receptor signaling pathway IEA GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS GO:0007204 positive regulation of cytosolic calcium ion concentration IEA GO:0007568 aging IEA GO:0008347 glial cell migration IEA GO:0009612 response to mechanical stimulus IEA GO:0010469 regulation of receptor activity IEA GO:0010700 negative regulation of norepinephrine secretion IEA GO:0019233 sensory perception of pain ISS GO:0023019 signal transduction involved in regulation of gene expression IEA GO:0030168 platelet activation IEA GO:0032962 positive regulation of inositol trisphosphate biosynthetic process IEA GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA GO:0042312 regulation of vasodilation IEA GO:0042755 eating behavior IEA GO:0043270 positive regulation of ion transport IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0046887 positive regulation of hormone secretion IEA GO:0051100 negative regulation of binding IEA GO:0060406 positive regulation of penile erection ISS GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA GO:0070848 response to growth factor IEA GO:0071407 cellular response to organic cyclic compound ISS GO:0072659 protein localization to plasma membrane IEA GO:0090075 relaxation of muscle,8630005 TAS GO:0004872 receptor activity 9671706 IPI GO:0005515 protein binding IEA GO:0005524 ATP binding IEA GO:0031686 A1 adenosine receptor binding IEA GO:0043531 ADP binding ISS GO:0045028 G-protein coupled purinergic nucleotide receptor activity ISS GO:0045031 ATP-activated adenosine receptor activity IEA GO:0045032 ADP-activated adenosine receptor activity IEA GO:0046982 protein heterodimerization activity ISS GO:0097110 scaffold protein binding,hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04611 Platelet activation - Homo sapiens (human),CHEMBL CHEMBL2333770,P47900,Purinergic receptor P2Y1,1.0,PRIMARY,NO,CC(C)(C)c1ccccc1Oc2ncccc2NC(=O)Nc3ccc(OC(F)(F)F)cc3,6,13,"InChI=1S/C23H22F3N3O3/c1-22(2,3)17-7-4-5-9-19(17)31-20-18(8-6-14-27-20)29-21(30)28-15-10-12-16(13-11-15)32-23(24,25)26/h4-14H,1-3H3,(H2,28,29,30)",AHFLGPTXSIRAQK-UHFFFAOYSA-N,"c(""Purinergic receptor P2Y14"", ""Purinergic receptor P2Y11"", ""Pyrimidinergic receptor P2Y6"", ""Purinergic receptor P2Y2"", ""Unchecked"", ""Purinergic receptor P2Y12"", ""Purinergic receptor P2Y1"")",5028,P2RY1,"Hemostasis R-HSA-109582 Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 Signal amplification R-HSA-392518 G alpha (q) signalling events R-HSA-416476 P2Y receptors R-HSA-417957 Nucleotide-like (purinergic) receptors R-HSA-418038 ADP signalling through P2Y purinoceptor 1 R-HSA-418592 GPCR ligand binding R-HSA-500792 Platelet activation, signaling and aggregation R-HSA-76002 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907",GO:0005739 mitochondrion IEA GO:0005829 cytosol IEA GO:0005886 plasma membrane ISS GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 8630005 TAS GO:0009986 cell surface 23382103 IDA GO:0016323 basolateral plasma membrane IEA GO:0016324 apical plasma membrane IEA GO:0030425 dendrite ISS GO:0044297 cell body ISS GO:0045211 postsynaptic membrane ISS,ISS GO:0001934 positive regulation of protein phosphorylation IEA GO:0001973 adenosine receptor signaling pathway 8630005 TAS GO:0007166 cell surface receptor signaling pathway ISS GO:0007186 G-protein coupled receptor signaling pathway IEA GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway ISS GO:0007204 positive regulation of cytosolic calcium ion concentration IEA GO:0007568 aging IEA GO:0008347 glial cell migration IEA GO:0009612 response to mechanical stimulus IEA GO:0010469 regulation of receptor activity IEA GO:0010700 negative regulation of norepinephrine secretion IEA GO:0019233 sensory perception of pain ISS GO:0023019 signal transduction involved in regulation of gene expression IEA GO:0030168 platelet activation IEA GO:0032962 positive regulation of inositol trisphosphate biosynthetic process IEA GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA GO:0042312 regulation of vasodilation IEA GO:0042755 eating behavior IEA GO:0043270 positive regulation of ion transport IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0046887 positive regulation of hormone secretion IEA GO:0051100 negative regulation of binding IEA GO:0060406 positive regulation of penile erection ISS GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA GO:0070848 response to growth factor IEA GO:0071407 cellular response to organic cyclic compound ISS GO:0072659 protein localization to plasma membrane IEA GO:0090075 relaxation of muscle,8630005 TAS GO:0004872 receptor activity 9671706 IPI GO:0005515 protein binding IEA GO:0005524 ATP binding IEA GO:0031686 A1 adenosine receptor binding IEA GO:0043531 ADP binding ISS GO:0045028 G-protein coupled purinergic nucleotide receptor activity ISS GO:0045031 ATP-activated adenosine receptor activity IEA GO:0045032 ADP-activated adenosine receptor activity IEA GO:0046982 protein heterodimerization activity ISS GO:0097110 scaffold protein binding,hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04611 Platelet activation - Homo sapiens (human),CHEMBL CHEMBL2172272,Q9H244,Purinergic receptor P2Y12,1.0,PRIMARY,NO,CCOC(=O)N1CCN(CC1)C(=O)[C@H](CCC(=O)O)NC(=O)c2cc(OCC(=O)N3CCC[C@H]3C(=O)NC4CCC4)n(n2)c5ccccc5,2,7,"InChI=1S/C33H43N7O9/c1-2-48-33(47)38-18-16-37(17-19-38)32(46)24(13-14-29(42)43)35-30(44)25-20-28(40(36-25)23-10-4-3-5-11-23)49-21-27(41)39-15-7-12-26(39)31(45)34-22-8-6-9-22/h3-5,10-11,20,22,24,26H,2,6-9,12-19,21H2,1H3,(H,34,45)(H,35,44)(H,42,43)/t24-,26-/m0/s1",FLUYZJFNZSOIKH-AHWVRZQESA-N,"c(""Unchecked"", ""Purinergic receptor P2Y1"", ""Purinergic receptor P2Y12"")",64805,P2Y12,"R-HSA-109582 Hemostasis R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signaling R-HSA-392170 ADP signalling through P2Y purinoceptor 12 R-HSA-392518 Signal amplification R-HSA-417957 P2Y receptors R-HSA-418038 Nucleotide-like (purinergic) receptors R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding R-HSA-76002 Platelet activation, signaling and aggregation",mitochondrion GO:0005739 IEA plasma membrane GO:0005886 ISS plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 IBA caveola GO:0005901 IEA external side of plasma membrane GO:0009897 IEA basal plasma membrane GO:0009925 IEA cell surface GO:0009986 IDA 23382103 intrinsic component of membrane GO:0031224 IDA 12578987,"adenosine receptor signaling pathway GO:0001973 IEA substrate-dependent cell migration, cell extension GO:0006930 ISS G-protein coupled receptor signaling pathway GO:0007186 11104774 IDA adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 12578987 IMP hemostasis GO:0007599 11196645 NAS glial cell migration GO:0008347 IEA negative regulation of norepinephrine secretion GO:0010700 IEA G-protein coupled purinergic nucleotide receptor signaling pathway GO:0035589 IEA positive regulation of ion transport GO:0043270 IEA protein kinase B signaling GO:0043491 IEA positive regulation of GTPase activity GO:0043547 IEA negative regulation of cell differentiation GO:0045596 IEA regulation of calcium ion transport GO:0051924 IEA platelet aggregation GO:0070527 12578987 IMP calcium ion transmembrane transport GO:0070588 IEA cellular response to ATP GO:0071318 ISS potassium ion transmembrane transport GO:0071805 IEA regulation of microglial cell migration GO:1904139 ISS",G-protein coupled adenosine receptor activity GO:0001609 IEA ADP receptor activity GO:0001621 11104774 IDA ADP receptor activity GO:0001621 12578987 IMP guanyl-nucleotide exchange factor activity GO:0005085 TAS,Platelet activation - Homo sapiens (human) hsa04611,CHEMBL CHEMBL3577182,O00398,Putative P2Y purinoceptor 10,1.0,PRIMARY,NO,CCCCCCCCCCCOc1ccccc1CCC(=O)OC[C@@H](F)COP(=O)(O)OC[C@H](N)C(=O)O,3,3,"InChI=1S/C26H43FNO9P/c1-2-3-4-5-6-7-8-9-12-17-34-24-14-11-10-13-21(24)15-16-25(29)35-18-22(27)19-36-38(32,33)37-20-23(28)26(30)31/h10-11,13-14,22-23H,2-9,12,15-20,28H2,1H3,(H,30,31)(H,32,33)/t22-,23+/m1/s1",RJDYAPVWZJLYAA-PKTZIBPZSA-N,"c(""Probable G-protein coupled receptor 34"", ""Putative P2Y purinoceptor 10"", ""Probable G-protein coupled receptor 174"")",27334,P2Y10,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signaling R-HSA-416476 G alpha (q) signalling events R-HSA-417957 P2Y receptors R-HSA-418038 Nucleotide-like (purinergic) receptors R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,TAS GO:0005886 plasma membrane IEA GO:0016021 integral component of membrane,G-protein coupled purinergic nucleotide receptor signaling pathway GO:0035589 IEA,G-protein coupled purinergic nucleotide receptor activity GO:0045028 IEA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL3220046,Q15077,Pyrimidinergic receptor P2Y6,1.0,ORTHOGONAL,NO,O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP(=O)(O)OP(=O)(O)O)N2C=C\C(=N\OCc3cccc(Br)c3)\NC2=O,3,5,"InChI=1S/C16H20BrN3O12P2/c17-10-3-1-2-9(6-10)7-29-19-12-4-5-20(16(23)18-12)15-14(22)13(21)11(31-15)8-30-34(27,28)32-33(24,25)26/h1-6,11,13-15,21-22H,7-8H2,(H,27,28)(H,18,19,23)(H2,24,25,26)/t11-,13-,14-,15-/m1/s1",FGMXILSWRVITJV-NMFUWQPSSA-N,"c(""Pyrimidinergic receptor P2Y6"", ""Purinergic receptor P2Y2"", ""Pyrimidinergic receptor P2Y4"", ""Unchecked"")",5031,P2RY6,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 P2Y receptors R-HSA-417957 Nucleotide-like (purinergic) receptors R-HSA-418038 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,TAS GO:0005886 plasma membrane 8670200 TAS GO:0005887 integral component of plasma membrane IEA GO:0016323 basolateral plasma membrane IEA GO:0016324 apical plasma membrane,8670200 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS GO:0014911 positive regulation of smooth muscle cell migration IEA GO:0030321 transepithelial chloride transport IEA GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA GO:0071380 cellular response to prostaglandin E stimulus IEA GO:0071407 cellular response to organic cyclic compound IEA,8670200 GO:0004930 G-protein coupled receptor activity TAS 25416956 GO:0005515 protein binding IPI GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA GO:0045029 UDP-activated nucleotide receptor activity IEA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL3220052,Q15077,Pyrimidinergic receptor P2Y6,1.0,PRIMARY,NO,CCN(CC)CC.Nc1ccc2C(=C3C=CC(=N)C(=C3Oc2c1S(=O)(=O)O)S(=O)(=O)O)c4ccc(cc4C(=O)O)C(=O)NCCCCCCn5cc(CCC#Cc6cccc(CO\N=C\7/NC(=O)N(C=C7)[C@@H]8O[C@H](COP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]8O)c6)nn5,3,10,"InChI=1S/C49H51N9O22P2S2.C6H15N/c50-35-16-14-32-39(33-15-17-36(51)45(84(73,74)75)43(33)79-42(32)44(35)83(70,71)72)31-13-12-29(23-34(31)48(62)63)46(61)52-19-5-1-2-6-20-57-24-30(54-56-57)11-4-3-8-27-9-7-10-28(22-27)25-76-55-38-18-21-58(49(64)53-38)47-41(60)40(59)37(78-47)26-77-82(68,69)80-81(65,66)67;1-4-7(5-2)6-3/h7,9-10,12-18,21-24,37,40-41,47,50,59-60H,1-2,4-6,11,19-20,25-26,51H2,(H,52,61)(H,62,63)(H,68,69)(H,53,55,64)(H2,65,66,67)(H,70,71,72)(H,73,74,75);4-6H2,1-3H3/t37-,40-,41-,47-;/m1./s1",SRQZTMUTHMHAPZ-UOYXXSKYSA-N,"c(""Pyrimidinergic receptor P2Y6"", ""Purinergic receptor P2Y2"", ""Pyrimidinergic receptor P2Y4"", ""Unchecked"")",5031,P2RY6,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 P2Y receptors R-HSA-417957 Nucleotide-like (purinergic) receptors R-HSA-418038 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,TAS GO:0005886 plasma membrane 8670200 TAS GO:0005887 integral component of plasma membrane IEA GO:0016323 basolateral plasma membrane IEA GO:0016324 apical plasma membrane,8670200 GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS GO:0014911 positive regulation of smooth muscle cell migration IEA GO:0030321 transepithelial chloride transport IEA GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA GO:0071380 cellular response to prostaglandin E stimulus IEA GO:0071407 cellular response to organic cyclic compound IEA,8670200 GO:0004930 G-protein coupled receptor activity TAS 25416956 GO:0005515 protein binding IPI GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA GO:0045029 UDP-activated nucleotide receptor activity IEA,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL3314362,Q96P65,Pyroglutamylated RFamide peptide receptor,1.0,PRIMARY,NO,CN(C)Cc1cc2CCN(Cc2cc1C)C(=O)c3cc4cc(Cl)ccc4n3C,3,7,"InChI=1S/C23H26ClN3O/c1-15-9-19-14-27(8-7-16(19)10-18(15)13-25(2)3)23(28)22-12-17-11-20(24)5-6-21(17)26(22)4/h5-6,9-12H,7-8,13-14H2,1-4H3",CKRWGBKIBACFNV-UHFFFAOYSA-N,"c(""Voltage-gated potassium channel beta subunit Mink"", ""Sodium channel protein type V alpha subunit"", ""Unchecked"", ""Pyroglutamylated RFamide peptide receptor"")",84109,QRFPR,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-389397 Orexin and neuropeptides FF and QRFP bind to their respective receptors R-HSA-416476 G alpha (q) signalling events R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 IBA integral component of membrane GO:0016021 12960173 IC,G-protein coupled receptor signaling pathway IDA 12960173 GO:0007186 neuropeptide signaling pathway IEA GO:0007218 cellular response to hormone stimulus IBA GO:0032870 response to peptide IBA GO:1901652,G-protein coupled receptor activity IDA 12960173 GO:0004930 neuropeptide Y receptor activity IEA GO:0004983 peptide binding IBA GO:0042277,,CHEMBL CHEMBL457992,P16083,Quinone reductase 2,1.0,PRIMARY,NO,CNS(=O)(=O)c1ccc2cccc(CCNC(=O)c3occc3)c2c1,3,6,"InChI=1S/C18H18N2O4S/c1-19-25(22,23)15-8-7-13-4-2-5-14(16(13)12-15)9-10-20-18(21)17-6-3-11-24-17/h2-8,11-12,19H,9-10H2,1H3,(H,20,21)",ZMQJWTSYMGTHFB-UHFFFAOYSA-N,"c(""Quinone reductase 2"", ""Melatonin receptor 1A"", ""Melatonin receptor 1B"", ""Unchecked"")",4835,NQO2,,nucleoplasm GO:0005654 IDA cytoplasm GO:0005737 IDA extracellular exosome 19056867 23376485 23533145 GO:0070062 IDA,GO:0007613 memory IEA GO:0055114 oxidation-reduction process IEA,GO:0005515 protein binding 25416956 IPI GO:0008753 NADPH dehydrogenase (quinone) activity 1691923 TAS GO:0009055 electron carrier activity 1691923 TAS GO:0046872 metal ion binding IEA,,CHEMBL CHEMBL375671,P04626,Receptor protein-tyrosine kinase erbB-2,1.0,PRIMARY,NO,Cc1cc(Nc2ncnc3cnc(cc23)N4CCOCC4)ccc1Oc5ccc(cc5)C(=O)NCC(C)(C)C,14,17,"InChI=1S/C30H34N6O3/c1-20-15-22(7-10-26(20)39-23-8-5-21(6-9-23)29(37)32-18-30(2,3)4)35-28-24-16-27(36-11-13-38-14-12-36)31-17-25(24)33-19-34-28/h5-10,15-17,19H,11-14,18H2,1-4H3,(H,32,37)(H,33,34,35)",KKWBRQPIXLDPAR-UHFFFAOYSA-N,"c(""Cyclin-dependent kinase 2"", ""Insulin-like growth factor I receptor"", ""Insulin receptor"", ""Epidermal growth factor receptor erbB1"", ""Receptor protein-tyrosine kinase erbB-2"", ""Epidermal growth factor receptor and ErbB2 (HER1 and HER2)"", ""Cyclin-dependent kinase 5"", ""Tyrosine-protein kinase SRC"", ""Tyrosine-protein kinase FES"", ""Protein kinase C alpha"", ""Tyrosine-protein kinase JAK3"", ""Protein kinase C theta"", ""Tyrosine-protein kinase LCK"", ""Platelet-derived growth factor receptor beta"", ""cAMP-dependent protein kinase (PKA)"", ""Serine/threonine-protein kinase WEE1"")",2064,ERBB2,"R-HSA-112399 IRS-mediated signalling R-HSA-112412 SOS-mediated signalling R-HSA-1168372 Downstream signaling events of B Cell Receptor (BCR) R-HSA-1227986 Signaling by ERBB2 R-HSA-1236394 Signaling by ERBB4 R-HSA-1250196 SHC1 events in ERBB2 signaling R-HSA-1250342 PI3K events in ERBB4 signaling R-HSA-1250347 SHC1 events in ERBB4 signaling R-HSA-1251932 PLCG1 events in ERBB2 signaling R-HSA-1257604 PIP3 activates AKT signaling R-HSA-1266738 Developmental Biology R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-1280218 Adaptive Immune System R-HSA-1306955 GRB7 events in ERBB2 signaling R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling R-HSA-1433557 Signaling by SCF-KIT R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-166520 Signalling by NGF R-HSA-167044 Signalling to RAS R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-169893 Prolonged ERK activation events R-HSA-170968 Frs2-mediated activation R-HSA-170984 ARMS-mediated activation R-HSA-177929 Signaling by EGFR R-HSA-179812 GRB2 events in EGFR signaling R-HSA-180292 GAB1 signalosome R-HSA-180336 SHC1 events in EGFR signaling R-HSA-186763 Downstream signal transduction R-HSA-186797 Signaling by PDGF R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-187687 Signalling to ERKs R-HSA-187706 Signalling to p38 via RIT and RIN R-HSA-190236 Signaling by FGFR R-HSA-194138 Signaling by VEGF R-HSA-1963640 GRB2 events in ERBB2 signaling R-HSA-1963642 PI3K events in ERBB2 signaling R-HSA-198203 PI3K/AKT activation R-HSA-2172127 DAP12 interactions R-HSA-2219528 PI3K/AKT Signaling in Cancer R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer R-HSA-2404192 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2424491 DAP12 signaling R-HSA-2428924 IGF1R signaling cascade R-HSA-2428928 IRS-related events triggered by IGF1R R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-2586552 Signaling by Leptin R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-2871796 FCERI mediated MAPK activation R-HSA-372790 Signaling by GPCR R-HSA-373755 Semaphorin interactions R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-400685 Sema4D in semaphorin signaling R-HSA-416572 Sema4D induced cell migration and growth-cone collapse R-HSA-422475 Axon guidance R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-449147 Signaling by Interleukins R-HSA-451927 Interleukin-2 signaling R-HSA-512988 Interleukin-3, 5 and GM-CSF signaling R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-5654687 Downstream signaling of activated FGFR1 R-HSA-5654689 PI-3K cascade:FGFR1 R-HSA-5654693 FRS-mediated FGFR1 signaling R-HSA-5654695 PI-3K cascade:FGFR2 R-HSA-5654696 Downstream signaling of activated FGFR2 R-HSA-5654700 FRS-mediated FGFR2 signaling R-HSA-5654706 FRS-mediated FGFR3 signaling R-HSA-5654708 Downstream signaling of activated FGFR3 R-HSA-5654710 PI-3K cascade:FGFR3 R-HSA-5654712 FRS-mediated FGFR4 signaling R-HSA-5654716 Downstream signaling of activated FGFR4 R-HSA-5654720 PI-3K cascade:FGFR4 R-HSA-5654736 Signaling by FGFR1 R-HSA-5654738 Signaling by FGFR2 R-HSA-5654741 Signaling by FGFR3 R-HSA-5654743 Signaling by FGFR4 R-HSA-5663202 Diseases of signal transduction R-HSA-5673001 RAF/MAP kinase cascade R-HSA-5683057 MAPK family signaling cascades R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-74751 Insulin receptor signalling cascade R-HSA-74752 Signaling by Insulin receptor R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-912526 Interleukin receptor SHC signaling R-HSA-983705 Signaling by the B Cell Receptor (BCR)",IDA 16314522 21555369 nucleus GO:0005634 IDA GO:0005737 cytoplasm IDA 20010870 plasma membrane GO:0005886 NAS 12000754 plasma membrane GO:0005886 TAS GO:0005886 plasma membrane IDA 16314522 endosome membrane GO:0010008 NAS 15609325 integral component of membrane GO:0016021 IDA 12646923 basolateral plasma membrane GO:0016323 IEA GO:0016324 apical plasma membrane IEA GO:0031410 cytoplasmic vesicle IEA GO:0043209 myelin sheath IDA 7514177 23382219 receptor complex GO:0043235 TAS 7556068 receptor complex GO:0043235 IEA GO:0048471 perinuclear region of cytoplasm,"MAPK cascade GO:0000165 TAS positive regulation of protein phosphorylation GO:0001934 ISS transcription, DNA-templated GO:0006351 IEA protein phosphorylation GO:0006468 10851066 TAS signal transduction GO:0007165 10572067 IDA cell surface receptor signaling pathway GO:0007166 9685399 IDA enzyme linked receptor protein signaling pathway GO:0007167 9590694 TAS transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 7514177 IDA transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 7556068 TAS peripheral nervous system development GO:0007422 IEA heart development GO:0007507 IEA neuromuscular junction development GO:0007528 IEA motor neuron axon guidance GO:0008045 IEA cell proliferation GO:0008283 10851066 TAS phosphatidylinositol 3-kinase signaling GO:0014065 7556068 IDA regulation of phosphatidylinositol 3-kinase signaling GO:0014066 TAS peptidyl-tyrosine phosphorylation GO:0018108 IEA positive regulation of cell growth GO:0030307 21555369 IMP regulation of microtubule-based process GO:0032886 20937854 IDA negative regulation of immature T cell proliferation in thymus GO:0033088 IEA ERBB2 signaling pathway GO:0038128 TAS wound healing GO:0042060 12646923 IDA myelination GO:0042552 IEA positive regulation of MAP kinase activity GO:0043406 10572067 IDA positive regulation of GTPase activity GO:0043547 ISS positive regulation of translation GO:0045727 21555369 IMP regulation of angiogenesis GO:0045765 15609325 NAS positive regulation of cell adhesion GO:0045785 7556068 IDA positive regulation of transcription from RNA polymerase I promoter GO:0045943 21555369 IMP positive regulation of transcription from RNA polymerase III promoter GO:0045945 19372587 IDA protein autophosphorylation GO:0046777 7556068 IDA phosphatidylinositol phosphorylation GO:0046854 IEA phosphatidylinositol-mediated signaling GO:0048015 TAS oligodendrocyte differentiation GO:0048709 IEA positive regulation of epithelial cell proliferation GO:0050679 10572067 IDA regulation of ERK1 and ERK2 cascade GO:0070372 16314522 IMP cellular response to growth factor stimulus GO:0071363 20010870 IDA positive regulation of protein targeting to membrane GO:0090314 20010870 IDA regulation of cell motility GO:2000145 TAS","21555369 GO:0001042 RNA polymerase I core binding IDA 7556068 GO:0004713 protein tyrosine kinase activity IDA 7556068 GO:0004713 protein tyrosine kinase activity IGI GO:0004713 protein tyrosine kinase activity TAS 7514177 GO:0004714 transmembrane receptor protein tyrosine kinase activity IDA GO:0004716 receptor signaling protein tyrosine kinase activity IEA 7514177 GO:0004888 transmembrane signaling receptor activity IDA GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS 7592681 9079677 10572067 10805725 11940572 12061724 12122014 12975581 15657067 16273093 16314522 16516204 16767099 16843263 17426253 19167335 19372587 19411071 19650109 20010870 20227043 20558745 20700126 20876300 21034468 21075308 21255571 21278786 21376233 21555369 21724847 21840311 22279592 22589551 22806884 22939624 23436906 23680147 23688700 23866081 24189400 24412244 24557338 24658140 24815698 25036637 25241761 25640309 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA 15520177 GO:0008022 protein C-terminus binding IPI 7514177 GO:0019838 growth factor binding IDA contributes_to 15899872 GO:0019903 protein phosphatase binding IPI 16843263 19650109 21255571 21480528 23436906 GO:0042802 identical protein binding IPI 9590694 GO:0043125 ErbB-3 class receptor binding TAS GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS 10572067 GO:0046982 protein heterodimerization activity IDA 7556068 GO:0046982 protein heterodimerization activity IPI 12000754 GO:0046983 protein dimerization activity NAS",hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04066 HIF-1 signaling pathway - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04520 Adherens junction - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05206 MicroRNAs in cancer - Homo sapiens (human) hsa05212 Pancreatic cancer - Homo sapiens (human) hsa05213 Endometrial cancer - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human) hsa05219 Bladder cancer - Homo sapiens (human) hsa05223 Non-small cell lung cancer - Homo sapiens (human) hsa05230 Central carbon metabolism in cancer - Homo sapiens (human),CHEMBL CHEMBL133725,P10276,Retinoic acid receptor alpha,1.0,ORTHOGONAL,NO,CC1(C)CCC(C)(C)c2nc(cnc12)c3ccc([nH]3)c4ccc(cc4)C(=O)O,3,7,"InChI=1S/C23H25N3O2/c1-22(2)11-12-23(3,4)20-19(22)24-13-18(26-20)17-10-9-16(25-17)14-5-7-15(8-6-14)21(27)28/h5-10,13,25H,11-12H2,1-4H3,(H,27,28)",RREMNJZTZUKGKQ-UHFFFAOYSA-N,"c(""Retinoic acid receptor alpha"", ""Retinoic acid receptor beta"", ""Retinoic acid receptor gamma"")",5914,RARA,Signal Transduction R-HSA-162582 HIV Infection R-HSA-162906 Host Interactions of HIV factors R-HSA-162909 Cell Cycle R-HSA-1640170 Disease R-HSA-1643685 Interactions of Rev with host cellular proteins R-HSA-177243 Nuclear import of Rev protein R-HSA-180746 Generic Transcription Pathway R-HSA-212436 Nuclear Receptor transcription pathway R-HSA-383280 Signaling by Retinoic Acid R-HSA-5362517 Infectious disease R-HSA-5663205 Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 Chromosome Maintenance R-HSA-73886 Gene Expression R-HSA-74160 Nucleosome assembly R-HSA-774815,17363140 GO:0000790 nuclear chromatin IDA 18845237 19917671 20080953 GO:0005634 nucleus IDA GO:0005654 nucleoplasm TAS 19850744 GO:0005737 cytoplasm IDA 2825025 GO:0009986 cell surface IC GO:0015629 actin cytoskeleton IDA GO:0030425 dendrite IEA GO:0043025 neuronal cell body IEA GO:0048471 perinuclear region of cytoplasm IEA,"negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA ureteric bud development GO:0001657 IEA neural tube closure GO:0001843 IEA liver development GO:0001889 IEA glandular epithelial cell development GO:0002068 IEA outflow tract septum morphogenesis GO:0003148 IEA growth plate cartilage development GO:0003417 IEA transcription initiation from RNA polymerase II promoter GO:0006367 TAS protein phosphorylation GO:0006468 IMP 16456540 signal transduction GO:0007165 IDA 2825025 germ cell development GO:0007281 IEA spermatogenesis GO:0007283 IEA female pregnancy GO:0007565 IEA positive regulation of cell proliferation GO:0008284 IMP 20080953 negative regulation of cell proliferation GO:0008285 IEA hippocampus development GO:0021766 IEA prostate gland development GO:0030850 IEA negative regulation of granulocyte differentiation GO:0030853 IDA 19917671 embryonic camera-type eye development GO:0031076 IEA regulation of myelination GO:0031641 IEA response to estradiol GO:0032355 IEA response to retinoic acid GO:0032526 IMP 17538076 negative regulation of interferon-gamma production GO:0032689 IDA 18416830 negative regulation of tumor necrosis factor production GO:0032720 IDA 18416830 positive regulation of interleukin-13 production GO:0032736 IDA 18416830 positive regulation of interleukin-4 production GO:0032753 IDA 18416830 positive regulation of interleukin-5 production GO:0032754 IDA 18416830 response to vitamin A GO:0033189 IEA response to cytokine GO:0034097 IEA multicellular organism growth GO:0035264 IEA negative regulation of apoptotic process GO:0043066 IEA apoptotic cell clearance GO:0043277 IMP 19628791 steroid hormone mediated signaling pathway GO:0043401 IEA response to ethanol GO:0045471 IEA positive regulation of T-helper 2 cell differentiation GO:0045630 IDA 18416830 positive regulation of neuron differentiation GO:0045666 IEA positive regulation of cell cycle GO:0045787 IMP 20080953 negative regulation of transcription, DNA-templated GO:0045892 IDA 20080953 positive regulation of transcription, DNA-templated GO:0045893 IDA 18845237 19850744 20080953 positive regulation of transcription, DNA-templated GO:0045893 IMP 19628791 positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA 19850744 positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP 20080953 negative regulation of translational initiation GO:0045947 IEA regulation of synaptic plasticity GO:0048167 IEA retinoic acid receptor signaling pathway GO:0048384 IMP 17538076 positive regulation of binding GO:0051099 IMP 20080953 ventricular cardiac muscle cell differentiation GO:0055012 IEA Sertoli cell fate commitment GO:0060010 IEA limb development GO:0060173 IEA face development GO:0060324 IEA trachea cartilage development GO:0060534 IEA chondroblast differentiation GO:0060591 IEA negative regulation of cartilage development GO:0061037 IEA cellular response to lipopolysaccharide GO:0071222 IEA cellular response to retinoic acid GO:0071300 IDA 19917671 cellular response to estrogen stimulus GO:0071391 IDA 20080953","translation repressor activity, nucleic acid binding GO:0000900 IEA RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 IEA retinoic acid binding GO:0001972 IDA 2825025 transcription factor activity, sequence-specific DNA binding GO:0003700 IDA 18922886 20413580 steroid hormone receptor activity GO:0003707 IEA retinoic acid receptor activity GO:0003708 IDA 2825025 transcription coactivator activity GO:0003713 IDA 2825025 20080953 transcription coactivator activity GO:0003713 IMP 19917671 transcription corepressor activity GO:0003714 IDA 20080953 receptor binding GO:0005102 IDA 19628791 protein binding GO:0005515 IPI 9653119 16189514 16456540 16606617 17363140 17560333 17641689 19345331 19850744 19917671 19934264 20080953 21516116 21988832 22056876 23518351 24819975 25036637 25241761 25303530 25416956 transcription factor binding GO:0008134 IPI 17641689 drug binding GO:0008144 IEA zinc ion binding GO:0008270 IEA enzyme binding GO:0019899 IPI 9628876 12039952 protein domain specific binding GO:0019904 IPI 20413580 chromatin DNA binding GO:0031490 IDA 19917671 histone deacetylase binding GO:0042826 IEA protein kinase B binding GO:0043422 IPI 16417524 retinoic acid-responsive element binding GO:0044323 IDA 19917671 protein heterodimerization activity GO:0046982 IDA 19917671 mRNA 5'-UTR binding GO:0048027 IEA protein kinase A binding GO:0051018 IDA 20215566 alpha-actinin binding GO:0051393 IPI 22351778",Pathways in cancer - Homo sapiens (human) hsa05200 Transcriptional misregulation in cancer - Homo sapiens (human) hsa05202 Acute myeloid leukemia - Homo sapiens (human) hsa05221,CHEMBL CHEMBL25202,P10276,Retinoic acid receptor alpha,1.0,PRIMARY,NO,CC1(C)CCC(C)(C)c2cc(NC(=O)c3ccc(cc3)C(=O)O)ccc12,3,139,"InChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-16(9-10-17(18)21)23-19(24)14-5-7-15(8-6-14)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)",MUTNCGKQJGXKEM-UHFFFAOYSA-N,"c(""HL-60"", ""Retinoic acid receptor alpha"", ""Retinoic acid receptor beta"", ""Retinoic acid receptor gamma"", ""Unchecked"", ""Jurkat"", ""U-937"", ""MOLT-4"", ""Menin/Histone-lysine N-methyltransferase MLL"", ""Histone acetyltransferase GCN5"", ""Vitamin D receptor"", ""Ubiquitin carboxyl-terminal hydrolase 1"", ""NB-4"", ""K562"", ""MDA-N"", ""SN12C"", ""ACHN"", ""NCI-H23"", ""HOP-92"", ""UO-31"", ""DU-145"", ""SK-MEL-5"", ""SF-539"", ""Malme-3M"", ""A498"", ""OVCAR-3"", ""NCI/ADR-RES"", ""HOP-62"", ""OVCAR-8"", ""U-251"", ""SNB-19"", ""OVCAR-5"", ""MDA-MB-231"", ""TK-10"", ""SR"", ""SW-620"", ""KM12"", ""NCI-H522"", ""M14"", ""NCI-H322M"", ""RPMI-8226"", ""OVCAR-4"", ""LOX IMVI"", ""BT-549"", ""SK-MEL-2"", ""HCC 2998"", ""A549"", ""SNB-75"", ""HCT-116"", ""HCT-15"", ""EKVX"", ""SF-268"", ""PC-3"", ""MCF7"", ""SK-OV-3"", ""T47D"", ""NCI-H460"", ""UACC-62"", ""CAKI-1"", ""SF-295"", ""MDA-MB-435"", ""IGROV-1"", ""786-0"", ""Hs-578T"", ""UACC-257"", ""CCRF-CEM"", ""HT-29"", ""NCI-H226"", ""RXF 393"", ""SK-MEL-28"", ""COLO 205"", ""Heat shock protein beta-1"")",5914,RARA,Signal Transduction R-HSA-162582 HIV Infection R-HSA-162906 Host Interactions of HIV factors R-HSA-162909 Cell Cycle R-HSA-1640170 Disease R-HSA-1643685 Interactions of Rev with host cellular proteins R-HSA-177243 Nuclear import of Rev protein R-HSA-180746 Generic Transcription Pathway R-HSA-212436 Nuclear Receptor transcription pathway R-HSA-383280 Signaling by Retinoic Acid R-HSA-5362517 Infectious disease R-HSA-5663205 Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-606279 Chromosome Maintenance R-HSA-73886 Gene Expression R-HSA-74160 Nucleosome assembly R-HSA-774815,17363140 GO:0000790 nuclear chromatin IDA 18845237 19917671 20080953 GO:0005634 nucleus IDA GO:0005654 nucleoplasm TAS 19850744 GO:0005737 cytoplasm IDA 2825025 GO:0009986 cell surface IC GO:0015629 actin cytoskeleton IDA GO:0030425 dendrite IEA GO:0043025 neuronal cell body IEA GO:0048471 perinuclear region of cytoplasm IEA,"negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA ureteric bud development GO:0001657 IEA neural tube closure GO:0001843 IEA liver development GO:0001889 IEA glandular epithelial cell development GO:0002068 IEA outflow tract septum morphogenesis GO:0003148 IEA growth plate cartilage development GO:0003417 IEA transcription initiation from RNA polymerase II promoter GO:0006367 TAS protein phosphorylation GO:0006468 IMP 16456540 signal transduction GO:0007165 IDA 2825025 germ cell development GO:0007281 IEA spermatogenesis GO:0007283 IEA female pregnancy GO:0007565 IEA positive regulation of cell proliferation GO:0008284 IMP 20080953 negative regulation of cell proliferation GO:0008285 IEA hippocampus development GO:0021766 IEA prostate gland development GO:0030850 IEA negative regulation of granulocyte differentiation GO:0030853 IDA 19917671 embryonic camera-type eye development GO:0031076 IEA regulation of myelination GO:0031641 IEA response to estradiol GO:0032355 IEA response to retinoic acid GO:0032526 IMP 17538076 negative regulation of interferon-gamma production GO:0032689 IDA 18416830 negative regulation of tumor necrosis factor production GO:0032720 IDA 18416830 positive regulation of interleukin-13 production GO:0032736 IDA 18416830 positive regulation of interleukin-4 production GO:0032753 IDA 18416830 positive regulation of interleukin-5 production GO:0032754 IDA 18416830 response to vitamin A GO:0033189 IEA response to cytokine GO:0034097 IEA multicellular organism growth GO:0035264 IEA negative regulation of apoptotic process GO:0043066 IEA apoptotic cell clearance GO:0043277 IMP 19628791 steroid hormone mediated signaling pathway GO:0043401 IEA response to ethanol GO:0045471 IEA positive regulation of T-helper 2 cell differentiation GO:0045630 IDA 18416830 positive regulation of neuron differentiation GO:0045666 IEA positive regulation of cell cycle GO:0045787 IMP 20080953 negative regulation of transcription, DNA-templated GO:0045892 IDA 20080953 positive regulation of transcription, DNA-templated GO:0045893 IDA 18845237 19850744 20080953 positive regulation of transcription, DNA-templated GO:0045893 IMP 19628791 positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA 19850744 positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP 20080953 negative regulation of translational initiation GO:0045947 IEA regulation of synaptic plasticity GO:0048167 IEA retinoic acid receptor signaling pathway GO:0048384 IMP 17538076 positive regulation of binding GO:0051099 IMP 20080953 ventricular cardiac muscle cell differentiation GO:0055012 IEA Sertoli cell fate commitment GO:0060010 IEA limb development GO:0060173 IEA face development GO:0060324 IEA trachea cartilage development GO:0060534 IEA chondroblast differentiation GO:0060591 IEA negative regulation of cartilage development GO:0061037 IEA cellular response to lipopolysaccharide GO:0071222 IEA cellular response to retinoic acid GO:0071300 IDA 19917671 cellular response to estrogen stimulus GO:0071391 IDA 20080953","translation repressor activity, nucleic acid binding GO:0000900 IEA RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 IEA retinoic acid binding GO:0001972 IDA 2825025 transcription factor activity, sequence-specific DNA binding GO:0003700 IDA 18922886 20413580 steroid hormone receptor activity GO:0003707 IEA retinoic acid receptor activity GO:0003708 IDA 2825025 transcription coactivator activity GO:0003713 IDA 2825025 20080953 transcription coactivator activity GO:0003713 IMP 19917671 transcription corepressor activity GO:0003714 IDA 20080953 receptor binding GO:0005102 IDA 19628791 protein binding GO:0005515 IPI 9653119 16189514 16456540 16606617 17363140 17560333 17641689 19345331 19850744 19917671 19934264 20080953 21516116 21988832 22056876 23518351 24819975 25036637 25241761 25303530 25416956 transcription factor binding GO:0008134 IPI 17641689 drug binding GO:0008144 IEA zinc ion binding GO:0008270 IEA enzyme binding GO:0019899 IPI 9628876 12039952 protein domain specific binding GO:0019904 IPI 20413580 chromatin DNA binding GO:0031490 IDA 19917671 histone deacetylase binding GO:0042826 IEA protein kinase B binding GO:0043422 IPI 16417524 retinoic acid-responsive element binding GO:0044323 IDA 19917671 protein heterodimerization activity GO:0046982 IDA 19917671 mRNA 5'-UTR binding GO:0048027 IEA protein kinase A binding GO:0051018 IDA 20215566 alpha-actinin binding GO:0051393 IPI 22351778",Pathways in cancer - Homo sapiens (human) hsa05200 Transcriptional misregulation in cancer - Homo sapiens (human) hsa05202 Acute myeloid leukemia - Homo sapiens (human) hsa05221,CHEMBL CHEMBL330998,P13631,Retinoic acid receptor gamma,1.0,PRIMARY,NO,C\C(=C/C(=O)O)\C=C\C=C(/C)\c1ccc2SCC(C)(C)c2c1,4,5,"InChI=1S/C19H22O2S/c1-13(10-18(20)21)6-5-7-14(2)15-8-9-17-16(11-15)19(3,4)12-22-17/h5-11H,12H2,1-4H3,(H,20,21)/b6-5+,13-10+,14-7+",LWOPJLGICWVJGG-SEBRYRKESA-N,"c(""Retinoic acid receptor alpha"", ""Retinoic acid receptor beta"", ""Retinoic acid receptor gamma"", ""Retinoid X receptor alpha"", ""CC-B"")",5916,RARG,R-HSA-162582 Signal Transduction R-HSA-212436 Generic Transcription Pathway R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-5362517 Signaling by Retinoic Acid R-HSA-74160 Gene Expression,nuclear chromatin IEA GO:0000790 nucleus IDA 18845237 GO:0005634 nucleus ISS GO:0005634 nucleoplasm IDA GO:0005654 nucleoplasm TAS GO:0005654 transcription factor complex ISS GO:0005667 integral component of membrane NAS 17943189 GO:0016021,ISS GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0001843 neural tube closure IEA GO:0002068 glandular epithelial cell development IEA GO:0003406 retinal pigment epithelium development IEA GO:0003430 growth plate cartilage chondrocyte growth TAS GO:0006367 transcription initiation from RNA polymerase II promoter IEA GO:0008284 positive regulation of cell proliferation ISS GO:0008285 negative regulation of cell proliferation TAS 18438858 regulation of cell size GO:0008361 IEA GO:0009952 anterior/posterior pattern specification IEA GO:0031076 embryonic camera-type eye development IEA GO:0031641 regulation of myelination IEA GO:0032331 negative regulation of chondrocyte differentiation IDA 17943189 response to retinoic acid GO:0032526 ISS GO:0035116 embryonic hindlimb morphogenesis IEA GO:0035264 multicellular organism growth ISS GO:0043065 positive regulation of apoptotic process IEA GO:0043066 negative regulation of apoptotic process ISS GO:0043068 positive regulation of programmed cell death IEA GO:0043401 steroid hormone mediated signaling pathway IEA GO:0045637 regulation of myeloid cell differentiation ISS GO:0045944 positive regulation of transcription from RNA polymerase II promoter ISS GO:0048048 embryonic eye morphogenesis IDA 17943189 retinoic acid receptor signaling pathway GO:0048384 TAS 18484682 canonical Wnt signaling pathway GO:0060070 IEA GO:0060324 face development IEA GO:0060534 trachea cartilage development IEA GO:0060740 prostate gland epithelium morphogenesis IEA GO:0070384 Harderian gland development IEA GO:0071300 cellular response to retinoic acid,"IEA GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding ISS GO:0003677 DNA binding ISS GO:0003700 transcription factor activity, sequence-specific DNA binding IEA GO:0003707 steroid hormone receptor activity IEA GO:0003708 retinoic acid receptor activity IPI 10428834 15734736 16456540 20413580 protein binding GO:0005515 IEA GO:0008270 zinc ion binding ISS GO:0046965 retinoid X receptor binding",,CHEMBL CHEMBL101661,P19793,Retinoid X receptor alpha,1.0,PRIMARY,NO,CC1(C)CCC(C)(C)c2cc(C(=C)c3ccc(cc3)C(=O)O)c(Br)cc12,4,8,"InChI=1S/C23H25BrO2/c1-14(15-6-8-16(9-7-15)21(25)26)17-12-18-19(13-20(17)24)23(4,5)11-10-22(18,2)3/h6-9,12-13H,1,10-11H2,2-5H3,(H,25,26)",JRRBUWNHWCKPBW-UHFFFAOYSA-N,"c(""Retinoic acid receptor alpha"", ""Retinoic acid receptor beta"", ""Retinoic acid receptor gamma"", ""Retinoid X receptor alpha"")",6256,RXRA,"Developmental Biology R-HSA-1266738 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1428517 Metabolism R-HSA-1430728 Recycling of bile acids and salts R-HSA-159418 Signal Transduction R-HSA-162582 Synthesis of bile acids and bile salts R-HSA-192105 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 Bile acid and bile salt metabolism R-HSA-194068 Import of palmitoyl-CoA into the mitochondrial matrix R-HSA-200425 Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 Biological oxidations R-HSA-211859 Cytochrome P450 - arranged by substrate type R-HSA-211897 Phase 1 - Functionalization of compounds R-HSA-211945 Endogenous sterols R-HSA-211976 Generic Transcription Pathway R-HSA-212436 Transcriptional regulation of white adipocyte differentiation R-HSA-381340 Nuclear Receptor transcription pathway R-HSA-383280 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-400206 Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-535734 Signaling by Retinoic Acid R-HSA-5362517 Metabolism of lipids and lipoproteins R-HSA-556833 Pyruvate metabolism R-HSA-70268 Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-71406 Gene Expression R-HSA-74160",GO:0000790 nuclear chromatin 18511497 IDA GO:0005634 nucleus 7990953 19917671 IDA GO:0005654 nucleoplasm TAS GO:0030424 axon IEA GO:0043235 receptor complex 17426122 IDA GO:0090575 RNA polymerase II transcription factor complex 17426122 18511497 IDA,17426122 IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0001701 in utero embryonic development IEA GO:0001889 liver development IEA GO:0001893 maternal placenta development TAS GO:0006367 transcription initiation from RNA polymerase II promoter 1651173 TAS GO:0006766 vitamin metabolic process IEA GO:0006954 inflammatory response IEA GO:0007494 midgut development IEA GO:0007566 embryo implantation IEA GO:0007568 aging 19374686 TAS GO:0008203 cholesterol metabolic process IEA GO:0008285 negative regulation of cell proliferation IEA GO:0010269 response to selenium ion TAS GO:0015721 bile acid and bile salt transport 11915042 IDA GO:0019048 modulation by virus of host morphology or physiology IEA GO:0031103 axon regeneration IEA GO:0031641 regulation of myelination 17538076 IMP GO:0032526 response to retinoic acid IEA GO:0032869 cellular response to insulin stimulus IEA GO:0033189 response to vitamin A IEA GO:0033280 response to vitamin D 10195690 IDA GO:0035357 peroxisome proliferator activated receptor signaling pathway IEA GO:0043010 camera-type eye development IEA GO:0043065 positive regulation of apoptotic process IEA GO:0043401 steroid hormone mediated signaling pathway TAS GO:0044255 cellular lipid metabolic process IEA GO:0045471 response to ethanol 12037571 20219900 IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0045994 positive regulation of translational initiation by iron 17538076 IMP GO:0048384 retinoic acid receptor signaling pathway 7831303 IDA GO:0051289 protein homotetramerization IEA GO:0051384 response to glucocorticoid IEA GO:0055010 ventricular cardiac muscle tissue morphogenesis IEA GO:0055012 ventricular cardiac muscle cell differentiation IEA GO:0060038 cardiac muscle cell proliferation IEA GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IEA GO:0060687 regulation of branching involved in prostate gland morphogenesis IEA GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus,"7831303 IDA GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding 12037571 IDA GO:0003677 DNA binding 12037571 20219900 IDA GO:0003700 transcription factor activity, sequence-specific DNA binding 17426122 IDA GO:0003700 contributes_to transcription factor activity, sequence-specific DNA binding IEA GO:0003707 steroid hormone receptor activity 19374686 TAS GO:0003708 retinoic acid receptor activity 1651173 TAS GO:0003713 transcription coactivator activity 7990953 IDA GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IEA GO:0004886 9-cis retinoic acid receptor activity 9653119 10428834 10866662 11915042 12040021 14701856 17363140 17426122 17641689 17673910 19345331 19786558 19917671 20219900 20541701 20682316 21988832 25241761 25303530 IPI GO:0005515 protein binding IEA GO:0008270 zinc ion binding 12039952 IPI GO:0019899 enzyme binding IEA GO:0019904 protein domain specific binding IEA GO:0031490 chromatin DNA binding IEA GO:0032403 protein complex binding 17426122 IPI GO:0042809 vitamin D receptor binding IEA GO:0042974 retinoic acid receptor binding 11915042 IDA GO:0043565 sequence-specific DNA binding 18511497 IDA GO:0044212 contributes_to transcription regulatory region DNA binding 19917671 IDA GO:0044323 retinoic acid-responsive element binding 19917671 IDA GO:0046982 protein heterodimerization activity 17426122 IDA GO:0070644 contributes_to vitamin D response element binding",hsa03320 PPAR signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) hsa04932 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa04976 Bile secretion - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) hsa05216 Thyroid cancer - Homo sapiens (human) hsa05222 Small cell lung cancer - Homo sapiens (human) hsa05223 Non-small cell lung cancer - Homo sapiens (human),CHEMBL CHEMBL80236,P19793,Retinoid X receptor alpha,1.0,PRIMARY,YES,C\C(=C/C(=O)O)\C=C\[C@H]1CCC[C@@H]1c2ccc3c(c2)C(C)(C)CCC3(C)C,4,11,"InChI=1S/C25H34O2/c1-17(15-23(26)27)9-10-18-7-6-8-20(18)19-11-12-21-22(16-19)25(4,5)14-13-24(21,2)3/h9-12,15-16,18,20H,6-8,13-14H2,1-5H3,(H,26,27)/b10-9+,17-15+/t18-,20+/m1/s1",HOAYGRVRYIUNNV-HOMFKRFTSA-N,"c(""Retinoic acid receptor beta"", ""Retinoic acid receptor gamma"", ""Retinoid X receptor alpha"", ""Retinoic acid receptor alpha"")",6256,RXRA,"Developmental Biology R-HSA-1266738 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1428517 Metabolism R-HSA-1430728 Recycling of bile acids and salts R-HSA-159418 Signal Transduction R-HSA-162582 Synthesis of bile acids and bile salts R-HSA-192105 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol R-HSA-193368 Synthesis of bile acids and bile salts via 27-hydroxycholesterol R-HSA-193807 Bile acid and bile salt metabolism R-HSA-194068 Import of palmitoyl-CoA into the mitochondrial matrix R-HSA-200425 Regulation of pyruvate dehydrogenase (PDH) complex R-HSA-204174 Biological oxidations R-HSA-211859 Cytochrome P450 - arranged by substrate type R-HSA-211897 Phase 1 - Functionalization of compounds R-HSA-211945 Endogenous sterols R-HSA-211976 Generic Transcription Pathway R-HSA-212436 Transcriptional regulation of white adipocyte differentiation R-HSA-381340 Nuclear Receptor transcription pathway R-HSA-383280 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-400206 Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-535734 Signaling by Retinoic Acid R-HSA-5362517 Metabolism of lipids and lipoproteins R-HSA-556833 Pyruvate metabolism R-HSA-70268 Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-71406 Gene Expression R-HSA-74160",GO:0000790 nuclear chromatin 18511497 IDA GO:0005634 nucleus 7990953 19917671 IDA GO:0005654 nucleoplasm TAS GO:0030424 axon IEA GO:0043235 receptor complex 17426122 IDA GO:0090575 RNA polymerase II transcription factor complex 17426122 18511497 IDA,17426122 IDA GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA GO:0001701 in utero embryonic development IEA GO:0001889 liver development IEA GO:0001893 maternal placenta development TAS GO:0006367 transcription initiation from RNA polymerase II promoter 1651173 TAS GO:0006766 vitamin metabolic process IEA GO:0006954 inflammatory response IEA GO:0007494 midgut development IEA GO:0007566 embryo implantation IEA GO:0007568 aging 19374686 TAS GO:0008203 cholesterol metabolic process IEA GO:0008285 negative regulation of cell proliferation IEA GO:0010269 response to selenium ion TAS GO:0015721 bile acid and bile salt transport 11915042 IDA GO:0019048 modulation by virus of host morphology or physiology IEA GO:0031103 axon regeneration IEA GO:0031641 regulation of myelination 17538076 IMP GO:0032526 response to retinoic acid IEA GO:0032869 cellular response to insulin stimulus IEA GO:0033189 response to vitamin A IEA GO:0033280 response to vitamin D 10195690 IDA GO:0035357 peroxisome proliferator activated receptor signaling pathway IEA GO:0043010 camera-type eye development IEA GO:0043065 positive regulation of apoptotic process IEA GO:0043401 steroid hormone mediated signaling pathway TAS GO:0044255 cellular lipid metabolic process IEA GO:0045471 response to ethanol 12037571 20219900 IDA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0045994 positive regulation of translational initiation by iron 17538076 IMP GO:0048384 retinoic acid receptor signaling pathway 7831303 IDA GO:0051289 protein homotetramerization IEA GO:0051384 response to glucocorticoid IEA GO:0055010 ventricular cardiac muscle tissue morphogenesis IEA GO:0055012 ventricular cardiac muscle cell differentiation IEA GO:0060038 cardiac muscle cell proliferation IEA GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IEA GO:0060687 regulation of branching involved in prostate gland morphogenesis IEA GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus,"7831303 IDA GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding 12037571 IDA GO:0003677 DNA binding 12037571 20219900 IDA GO:0003700 transcription factor activity, sequence-specific DNA binding 17426122 IDA GO:0003700 contributes_to transcription factor activity, sequence-specific DNA binding IEA GO:0003707 steroid hormone receptor activity 19374686 TAS GO:0003708 retinoic acid receptor activity 1651173 TAS GO:0003713 transcription coactivator activity 7990953 IDA GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IEA GO:0004886 9-cis retinoic acid receptor activity 9653119 10428834 10866662 11915042 12040021 14701856 17363140 17426122 17641689 17673910 19345331 19786558 19917671 20219900 20541701 20682316 21988832 25241761 25303530 IPI GO:0005515 protein binding IEA GO:0008270 zinc ion binding 12039952 IPI GO:0019899 enzyme binding IEA GO:0019904 protein domain specific binding IEA GO:0031490 chromatin DNA binding IEA GO:0032403 protein complex binding 17426122 IPI GO:0042809 vitamin D receptor binding IEA GO:0042974 retinoic acid receptor binding 11915042 IDA GO:0043565 sequence-specific DNA binding 18511497 IDA GO:0044212 contributes_to transcription regulatory region DNA binding 19917671 IDA GO:0044323 retinoic acid-responsive element binding 19917671 IDA GO:0046982 protein heterodimerization activity 17426122 IDA GO:0070644 contributes_to vitamin D response element binding",hsa03320 PPAR signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) hsa04932 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) hsa04976 Bile secretion - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human) hsa05216 Thyroid cancer - Homo sapiens (human) hsa05222 Small cell lung cancer - Homo sapiens (human) hsa05223 Non-small cell lung cancer - Homo sapiens (human),CHEMBL CHEMBL575741,Q13464,Rho-associated protein kinase 1,1.0,PRIMARY,NO,C1CN(CCN1)c2nc(NC3Cc4ccccc4C3)nc(Nc5ccncc5)n2,23,50,"InChI=1S/C21H24N8/c1-2-4-16-14-18(13-15(16)3-1)25-20-26-19(24-17-5-7-22-8-6-17)27-21(28-20)29-11-9-23-10-12-29/h1-8,18,23H,9-14H2,(H2,22,24,25,26,27,28)",IINABGAHVLQZSP-UHFFFAOYSA-N,"c(""Rho-associated protein kinase 1"", ""Unchecked"", ""Epidermal growth factor receptor erbB1"", ""Insulin receptor"", ""Serine/threonine-protein kinase 11"", ""Dual specificity mitogen-activated protein kinase kinase 1"", ""Platelet-derived growth factor receptor beta"", ""Neurotrophic tyrosine kinase receptor type 2"", ""Serine/threonine-protein kinase Aurora-A"", ""CaM kinase IV"", ""Cyclin-dependent kinase 2"", ""Serine/threonine-protein kinase Chk1"", ""Casein kinase I delta"", ""Serine/threonine-protein kinase RAF"", ""Tyrosine-protein kinase CSK"", ""Tyrosine-protein kinase SRC"", ""Glycogen synthase kinase-3 beta"", ""Tyrosine-protein kinase LCK"", ""MAP kinase-activated protein kinase 2"", ""Hepatocyte growth factor receptor"", ""Serine/threonine-protein kinase NEK2"", ""Serine/threonine-protein kinase PAK 2"", ""Ribosomal protein S6 kinase alpha 3"", ""Tyrosine-protein kinase ZAP-70"")",6093,ROCK1,R-HSA-109581 Apoptosis R-HSA-111465 Apoptotic cleavage of cellular proteins R-HSA-1266738 Developmental Biology R-HSA-162582 Signal Transduction R-HSA-194138 Signaling by VEGF R-HSA-194315 Signaling by Rho GTPases R-HSA-195258 RHO GTPase Effectors R-HSA-2682334 EPH-Ephrin signaling R-HSA-372790 Signaling by GPCR R-HSA-373755 Semaphorin interactions R-HSA-388396 GPCR downstream signaling R-HSA-3928662 EPHB-mediated forward signaling R-HSA-3928663 EPHA-mediated growth cone collapse R-HSA-400685 Sema4D in semaphorin signaling R-HSA-416482 G alpha (12/13) signalling events R-HSA-416572 Sema4D induced cell migration and growth-cone collapse R-HSA-422475 Axon guidance R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-5357801 Programmed Cell Death R-HSA-5627117 RHO GTPases Activate ROCKs R-HSA-75153 Apoptotic execution phase,Golgi membrane GO:0000139 IEA ruffle GO:0001726 ISS centriole GO:0005814 IEA cytosol GO:0005829 TAS cytoskeleton GO:0005856 ISS plasma membrane GO:0005886 ISS lamellipodium GO:0030027 ISS bleb GO:0032059 IEA,apical constriction GO:0003383 IEA protein phosphorylation GO:0006468 IEA cellular component disassembly involved in execution phase of apoptosis GO:0006921 TAS smooth muscle contraction GO:0006939 12778124 TAS leukocyte cell-cell adhesion GO:0007159 12082081 IDA signal transduction GO:0007165 10436159 TAS I-kappaB kinase/NF-kappaB signaling GO:0007249 25816133 IMP Rho protein signal transduction GO:0007266 IEA negative regulation of angiogenesis GO:0016525 19181962 IMP membrane to membrane docking GO:0022614 12082081 IDA actin cytoskeleton organization GO:0030036 10436159 TAS regulation of cell adhesion GO:0030155 12778124 TAS cortical actin cytoskeleton organization GO:0030866 25816133 IGI cortical actin cytoskeleton organization GO:0030866 25816133 IMP bleb assembly GO:0032060 IEA negative regulation of protein binding GO:0032091 18573880 IDA regulation of actin cytoskeleton organization GO:0032956 25911094 IDA regulation of actin cytoskeleton organization GO:0032956 12778124 TAS negative regulation of myosin-light-chain-phosphatase activity GO:0035509 25816133 IGI negative regulation of myosin-light-chain-phosphatase activity GO:0035509 25816133 IMP negative regulation of neuron apoptotic process GO:0043524 IEA regulation of keratinocyte differentiation GO:0045616 19997641 IMP vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS ephrin receptor signaling pathway GO:0048013 TAS leukocyte migration GO:0050900 12082081 IDA leukocyte tethering or rolling GO:0050901 12082081 IDA myoblast migration GO:0051451 ISS regulation of stress fiber assembly GO:0051492 12778124 TAS regulation of focal adhesion assembly GO:0051893 12778124 TAS positive regulation of focal adhesion assembly GO:0051894 ISS establishment of protein localization to plasma membrane GO:0090002 25816133 IGI establishment of protein localization to plasma membrane GO:0090002 25816133 IMP regulation of establishment of endothelial barrier GO:1903140 25816133 IGI regulation of establishment of endothelial barrier GO:1903140 25816133 IMP negative regulation of bicellular tight junction assembly GO:1903347 25816133 IGI regulation of establishment of cell polarity GO:2000114 20803696 TAS regulation of cell motility GO:2000145 12778124 TAS,protein kinase activity GO:0004672 8798490 10436159 TAS protein serine/threonine kinase activity GO:0004674 10652353 11018042 18573880 18694941 19036714 IDA protein serine/threonine kinase activity GO:0004674 TAS protein binding GO:0005515 10652353 14660612 17853893 20230755 21281639 22085929 25416956 25448675 IPI ATP binding GO:0005524 IEA GTP-Rho binding GO:0017049 IEA metal ion binding GO:0046872 IEA,cGMP-PKG signaling pathway - Homo sapiens (human) hsa04022 cAMP signaling pathway - Homo sapiens (human) hsa04024 Chemokine signaling pathway - Homo sapiens (human) hsa04062 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 Vascular smooth muscle contraction - Homo sapiens (human) hsa04270 TGF-beta signaling pathway - Homo sapiens (human) hsa04350 Axon guidance - Homo sapiens (human) hsa04360 Focal adhesion - Homo sapiens (human) hsa04510 Platelet activation - Homo sapiens (human) hsa04611 Leukocyte transendothelial migration - Homo sapiens (human) hsa04670 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04810 Oxytocin signaling pathway - Homo sapiens (human) hsa04921 Pathogenic Escherichia coli infection - Homo sapiens (human) hsa05130 Shigellosis - Homo sapiens (human) hsa05131 Salmonella infection - Homo sapiens (human) hsa05132 Pathways in cancer - Homo sapiens (human) hsa05200 Proteoglycans in cancer - Homo sapiens (human) hsa05205 MicroRNAs in cancer - Homo sapiens (human) hsa05206,CHEMBL CHEMBL1933279,P51812,Ribosomal protein S6 kinase alpha 3,1.0,PRIMARY,NO,Cn1c(NC(=O)c2ccc3cc4C(=O)NCCCn4c3c2)nc5ccccc15,18,24,"InChI=1S/C21H19N5O2/c1-25-16-6-3-2-5-15(16)23-21(25)24-19(27)14-8-7-13-11-18-20(28)22-9-4-10-26(18)17(13)12-14/h2-3,5-8,11-12H,4,9-10H2,1H3,(H,22,28)(H,23,24,27)",WIICYVHPNFINMO-UHFFFAOYSA-N,"c(""Serine/threonine-protein kinase Chk2"", ""Dual specificty protein kinase CLK1"", ""Dual specificity protein kinase CLK2"", ""Dual-specificity tyrosine-phosphorylation regulated kinase 1A"", ""Fibroblast growth factor receptor 2"", ""Vascular endothelial growth factor receptor 2"", ""Leucine-rich repeat serine/threonine-protein kinase 2"", ""Dual specificity mitogen-activated protein kinase kinase 1"", ""Mitogen-activated protein kinase kinase kinase kinase 2"", ""Mitogen-activated protein kinase kinase kinase kinase 4"", ""MAP kinase-activated protein kinase 5"", ""Nerve growth factor receptor Trk-A"", ""Platelet-derived growth factor receptor alpha"", ""Protein kinase C mu"", ""Tyrosine-protein kinase receptor RET"", ""AMP-activated protein kinase (AMPK) alpha-1/beta-1/gamma-1"", ""Serine/threonine-protein kinase Aurora-A"", ""Serine/threonine-protein kinase Aurora-B"", ""Cyclin-dependent kinase 1/cyclin B1"", ""Cyclin-dependent kinase 2/cyclin A"", ""Ribosomal protein S6 kinase alpha 3"")",6197,KS6A3,R-HSA-112314 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System R-HSA-1266738 Developmental Biology R-HSA-162582 Signal Transduction R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-166054 Activated TLR4 signalling R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-166166 MyD88-independent TLR3/TLR4 cascade R-HSA-166520 Signalling by NGF R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168180 TRAF6 Mediated Induction of proinflammatory cytokines R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-168898 Toll-Like Receptors Cascades R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-187037 NGF signalling via TRKA from the plasma membrane R-HSA-198725 Nuclear Events (kinase and transcription factor activation) R-HSA-198753 ERK/MAPK targets R-HSA-199920 CREB phosphorylation R-HSA-2262752 Cellular responses to stress R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) R-HSA-2559583 Cellular Senescence R-HSA-372790 Signaling by GPCR R-HSA-373760 L1CAM interactions R-HSA-422475 Axon guidance R-HSA-437239 Recycling pathway of L1 R-HSA-438064 Post NMDA receptor activation events R-HSA-442742 CREB phosphorylation through the activation of Ras R-HSA-442755 Activation of NMDA receptor upon glutamate binding and postsynaptic events R-HSA-444257 RSK activation R-HSA-450282 MAPK targets/ Nuclear events mediated by MAP kinases R-HSA-450294 MAP kinase activation in TLR cascade R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-937061 TRIF-mediated TLR3/TLR4 signaling R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-975871 MyD88 cascade initiated on plasma membrane,nucleus GO:0005634 IBA nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 IBA cytosol GO:0005829 TAS,skeletal system development GO:0001501 TAS 8955270 toll-like receptor signaling pathway GO:0002224 ISS protein phosphorylation GO:0006468 IEA cell cycle GO:0007049 IEA signal transduction GO:0007165 TAS 10436156 central nervous system development GO:0007417 TAS 10319851 positive regulation of cell growth GO:0030307 TAS 18813292 response to lipopolysaccharide GO:0032496 ISS intracellular signal transduction GO:0035556 IBA negative regulation of apoptotic process GO:0043066 TAS 18813292 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IDA 18402937 regulation of translation in response to stress GO:0043555 TAS 18813292 regulation of DNA-templated transcription in response to stress GO:0043620 TAS 18813292 positive regulation of cell differentiation GO:0045597 TAS 18813292 positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP 22065586,magnesium ion binding GO:0000287 IEA protein kinase activity GO:0004672 TAS 10436156 protein serine/threonine kinase activity GO:0004674 TAS protein binding GO:0005515 IPI 21988832 23602568 25241761 ATP binding GO:0005524 IEA kinase activity GO:0016301 TAS protein kinase binding GO:0019901 IEA cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043027 IDA 18402937,MAPK signaling pathway - Homo sapiens (human) hsa04010 Oocyte meiosis - Homo sapiens (human) hsa04114 mTOR signaling pathway - Homo sapiens (human) hsa04150 Long-term potentiation - Homo sapiens (human) hsa04720 Neurotrophin signaling pathway - Homo sapiens (human) hsa04722 Progesterone-mediated oocyte maturation - Homo sapiens (human) hsa04914,CHEMBL CHEMBL2325703,Q13535,Serine-protein kinase ATR,1.0,PRIMARY,NO,CC(C)(c1cc(nc(n1)c2cccc3[nH]ccc23)N4CCOCC4)S(=O)(=O)C,3,5,"InChI=1S/C20H24N4O3S/c1-20(2,28(3,25)26)17-13-18(24-9-11-27-12-10-24)23-19(22-17)15-5-4-6-16-14(15)7-8-21-16/h4-8,13,21H,9-12H2,1-3H3",TYPBASYBSGLAOL-UHFFFAOYSA-N,"c(""Serine/threonine-protein kinase mTOR"", ""Serine-protein kinase ATR"", ""PI3-kinase p110-alpha subunit"")",545,ATR,Meiotic synapsis R-HSA-1221632 Meiosis R-HSA-1500620 Cell Cycle R-HSA-1640170 Activation of ATR in response to replication stress R-HSA-176187 Cellular responses to stress R-HSA-2262752 Regulation of HSF1-mediated heat shock response R-HSA-3371453 Cellular response to heat stress R-HSA-3371556 Fanconi Anemia pathway R-HSA-419524 Regulation of the Fanconi anemia pathway R-HSA-419552 G2/M DNA damage checkpoint R-HSA-69473 G2/M Checkpoints R-HSA-69481 Cell Cycle Checkpoints R-HSA-69620 DNA Repair R-HSA-73894,"IC colocalizes_with 26586433 nuclear chromosome, telomeric region GO:0000784 IDA GO:0005654 nucleoplasm TAS GO:0005654 nucleoplasm ISS GO:0005694 chromosome IDA GO:0005794 Golgi apparatus IDA 12814551 PML body GO:0016605","DNA damage checkpoint 14657349 GO:0000077 IDA DNA replication GO:0006260 TAS DNA repair 8610130 GO:0006281 TAS cellular response to DNA damage stimulus 15538388 GO:0006974 TAS cell cycle 9590286 GO:0007049 TAS multicellular organism development 9590286 GO:0007275 TAS negative regulation of DNA replication 14657349 GO:0008156 IMP peptidyl-serine phosphorylation 9733515 GO:0018105 IDA positive regulation of telomere maintenance via telomerase GO:0032212 ISS cellular response to UV 9925639 GO:0034644 IMP interstrand cross-link repair GO:0036297 TAS response to drug GO:0042493 IEA positive regulation of DNA damage response, signal transduction by p53 class mediator 9925639 GO:0043517 IMP protein autophosphorylation 9733515 GO:0046777 IDA protein localization to chromosome, telomeric region 21829167 GO:0070198 IMP cellular response to gamma radiation 9925639 GO:0071480 IDA replicative senescence 15149599 GO:0090399 IMP establishment of RNA localization to telomere 26586433 GO:0097694 IMP establishment of macromolecular complex localization to telomere 26586433 GO:0097695 IC regulation of cellular response to heat GO:1900034 TAS regulation of signal transduction by p53 class mediator GO:1901796 TAS positive regulation of telomerase catalytic core complex assembly 26586433 GO:1904884 IMP",GO:0003677 DNA binding IEA 14657349 GO:0004672 protein kinase activity IDA 9733515 9925639 GO:0004674 protein serine/threonine kinase activity IDA GO:0004674 protein serine/threonine kinase activity TAS 14657349 18583959 19633697 20810650 20864032 20930849 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA 16713580 GO:0032405 MutLalpha complex binding IDA 16713580 GO:0032407 MutSalpha complex binding IDA,hsa03460 Fanconi anemia pathway - Homo sapiens (human) hsa04110 Cell cycle - Homo sapiens (human) hsa04115 p53 signaling pathway - Homo sapiens (human) hsa05166 HTLV-I infection - Homo sapiens (human),CHEMBL CHEMBL483158,O14965,Serine/threonine-protein kinase Aurora-A,1.0,PRIMARY,NO,COc1cccc(F)c1C2=NCc3cnc(Nc4ccc(C(=O)O)c(OC)c4)nc3c5ccc(Cl)cc25,4,192,"InChI=1S/C27H20ClFN4O4/c1-36-21-5-3-4-20(29)23(21)25-19-10-15(28)6-8-17(19)24-14(12-30-25)13-31-27(33-24)32-16-7-9-18(26(34)35)22(11-16)37-2/h3-11,13H,12H2,1-2H3,(H,34,35)(H,31,32,33)",ZLHFILGSQDJULK-UHFFFAOYSA-N,"c(""Serine/threonine-protein kinase Aurora-A"", ""Serine/threonine-protein kinase Aurora-B"", ""Tyrosine-protein kinase LCK"", ""Inhibitor of nuclear factor kappa B kinase epsilon subunit"", ""Serine/threonine-protein kinase MST2"", ""Dual specificity protein kinase CLK2"", ""Serine/threonine-protein kinase MRCK-A"", ""Serine/threonine-protein kinase PLK3"", ""Macrophage-stimulating protein receptor"", ""CaM kinase II alpha"", ""Casein kinase I gamma 2"", ""Dual specificity mitogen-activated protein kinase kinase 1"", ""Serine/threonine-protein kinase TBK1"", ""ALK tyrosine kinase receptor"", ""Tyrosine-protein kinase SYK"", ""Protein kinase C theta"", ""CaM kinase II gamma"", ""Serine/threonine-protein kinase AKT3"", ""Serine/threonine-protein kinase PLK4"", ""Macrophage colony stimulating factor receptor"", ""Tyrosine-protein kinase JAK2"", ""Leukocyte tyrosine kinase receptor"", ""NT-3 growth factor receptor"", ""Tyrosine-protein kinase CTK"", ""Tyrosine-protein kinase receptor RET"", ""BR serine/threonine-protein kinase 1"", ""Casein kinase I isoform gamma-3"", ""Protein kinase C zeta"", ""AMP-activated protein kinase, alpha-1 subunit"", ""PDZ-binding kinase"", ""Dual specificity mitogen-activated protein kinase kinase 2"", ""MAP kinase p38 alpha"", ""cGMP-dependent protein kinase 1 beta"", ""Serine/threonine-protein kinase D2"", ""Tyrosine-protein kinase FRK"", ""cGMP-dependent protein kinase 2"", ""Ribosomal protein S6 kinase alpha 3"", ""Mitogen-activated protein kinase kinase kinase kinase 4"", ""Phosphorylase kinase gamma subunit 2"", ""Ribosomal protein S6 kinase 1"", ""Dual-specificity tyrosine-phosphorylation regulated kinase 1A"", ""Protein kinase C delta"", ""MAP kinase p38 delta"", ""Dual specificity tyrosine-phosphorylation-regulated kinase 1B"", ""Leucine-rich repeat serine/threonine-protein kinase 2"", ""Rho-associated protein kinase 2"", ""Serine/threonine-protein kinase PIM1"", ""Casein kinase I gamma 1"", ""Tyrosine-protein kinase SRC"", ""Hepatocyte growth factor receptor"", ""Serine/threonine-protein kinase 17A"", ""LIM domain kinase 1"", ""Tyrosine-protein kinase Srms"", ""Serine/threonine-protein kinase Chk1"", ""Serine/threonine-protein kinase Sgk2"", ""Stem cell growth factor receptor"", ""Serine/threonine-protein kinase AKT2"", ""Serine/threonine-protein kinase c-TAK1"", ""Mixed lineage kinase 7"", ""Vascular endothelial growth factor receptor 2"", ""Tyrosine kinase non-receptor protein 2"", ""G protein-coupled receptor kinase 5"", ""Serine/threonine-protein kinase PRKX"", ""Cyclin-dependent kinase 2"", ""Serine/threonine-protein kinase TAO1"", ""Serine/threonine-protein kinase PIM3"", ""Platelet-derived growth factor receptor beta"", ""MAP kinase ERK2"", ""Casein kinase II alpha"", ""Nerve growth factor receptor Trk-A"", ""Casein kinase I delta"", ""MAP kinase-activated protein kinase 5"", ""Fibroblast growth factor receptor 1"", ""Proto-oncogene tyrosine-protein kinase ROS"", ""Glycogen synthase kinase-3 alpha"", ""Focal adhesion kinase 1"", ""Serine/threonine-protein kinase SRPK1"", ""Tyrosine-protein kinase FES"", ""Tyrosine-protein kinase TYK2"", ""Misshapen-like kinase 1"", ""Tyrosine-protein kinase receptor TYRO3"", ""Death-associated protein kinase 3"", ""c-Jun N-terminal kinase 2"", ""Tyrosine-protein kinase receptor FLT3"", ""Tyrosine-protein kinase ABL"", ""Cyclin-dependent kinase 5"", ""Interleukin-1 receptor-associated kinase 1"", ""MAP kinase-activated protein kinase 2"", ""Serine/threonine-protein kinase PAK 4"", ""Tyrosine-protein kinase BLK"", ""Mitogen-activated protein kinase kinase kinase kinase 2"", ""Serine/threonine-protein kinase Nek4"", ""Casein kinase I alpha"", ""Insulin receptor"", ""Epidermal growth factor receptor erbB1"", ""Receptor protein-tyrosine kinase erbB-2"", ""Ephrin type-A receptor 2"", ""Tyrosine-protein kinase BRK"", ""Serine/threonine-protein kinase Chk2"", ""c-Jun N-terminal kinase 1"", ""Tyrosine-protein kinase ITK/TSK"", ""Testis-specific serine/threonine-protein kinase 1"", ""MAP kinase signal-integrating kinase 2"", ""Protein kinase C nu"", ""Cell division cycle 7-related protein kinase"", ""Serine/threonine-protein kinase PAK 1"", ""Dual-specificity tyrosine-phosphorylation regulated kinase 3"", ""Dual specificity tyrosine-phosphorylation-regulated kinase 4"", ""Maternal embryonic leucine zipper kinase"", ""Activin receptor type-1"", ""Protein kinase N2"", ""Protein kinase C gamma"", ""MAP kinase-activated protein kinase 3"", ""CaM kinase II beta"", ""Testis-specific serine/threonine-protein kinase 2"", ""Tyrosine-protein kinase JAK3"", ""Homeodomain-interacting protein kinase 2"", ""Insulin-like growth factor I receptor"", ""Protein kinase C iota"", ""Platelet-derived growth factor receptor alpha"", ""Tyrosine-protein kinase BTK"", ""CaM kinase II delta"", ""Serine/threonine-protein kinase NEK2"", ""Serine/threonine-protein kinase PLK1"", ""Homeodomain-interacting protein kinase 4"", ""Cell division protein kinase 8"", ""Cyclin-dependent kinase 1"", ""Cyclin-dependent kinase 7"", ""Glycogen synthase kinase-3 beta"", ""cAMP-dependent protein kinase alpha-catalytic subunit"", ""Rho-associated protein kinase 1"", ""Cyclin-dependent kinase 9"", ""Interleukin-1 receptor-associated kinase 4"", ""Serine/threonine-protein kinase PIM2"", ""Vascular endothelial growth factor receptor 1"", ""Tyrosine-protein kinase FER"", ""MAP kinase p38 gamma"", ""Serine/threonine-protein kinase AKT"", ""3-phosphoinositide dependent protein kinase-1"", ""Serine/threonine-protein kinase 2"", ""Neurotrophic tyrosine kinase receptor type 2"", ""CaM kinase I alpha"", ""Dual specificity protein kinase CLK4"", ""Mitogen-activated protein kinase kinase kinase kinase 5"", ""Serine/threonine-protein kinase DCLK1"", ""Fibroblast growth factor receptor 3"", ""Receptor protein-tyrosine kinase erbB-4"", ""CaM kinase I delta"", ""Tyrosine-protein kinase FYN"", ""Unchecked"", ""Tyrosine-protein kinase YES"", ""NCI-H358"", ""HT-29"", ""GABA receptor alpha-1 subunit"", ""HCT-116"")",6790,AURKA,"Cell Cycle R-HSA-1640170 APC/C-mediated degradation of cell cycle proteins R-HSA-174143 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 Mitotic G2-G2/M phases R-HSA-453274 Regulation of mitotic cell cycle R-HSA-453276 G2/M Transition R-HSA-69275 Cell Cycle, Mitotic R-HSA-69278","IBA GO:0000780 condensed nuclear chromosome, centromeric region 20531406 IDA GO:0005634 nucleus TAS GO:0005654 nucleoplasm 17726514 21399614 21600873 IDA GO:0005813 centrosome 19774610 TAS GO:0005813 centrosome IEA GO:0005814 centriole 19774610 TAS GO:0005819 spindle TAS GO:0005829 cytosol 19801554 IDA GO:0005876 colocalizes_with spindle microtubule IEA GO:0005929 cilium 19801554 IDA GO:0015630 microtubule cytoskeleton 19774610 TAS GO:0030496 midbody 19801554 IDA GO:0031616 spindle pole centrosome IBA GO:0032133 chromosome passenger complex IEA GO:0042585 germinal vesicle IEA GO:0043203 axon hillock IEA GO:0045120 pronucleus 20531406 IDA GO:0048471 perinuclear region of cytoplasm IBA GO:0051233 spindle midzone IEA GO:0072686 mitotic spindle IEA GO:0072687 meiotic spindle","G2/M transition of mitotic cell cycle GO:0000086 TAS protein phosphorylation 21600873 21820309 GO:0006468 IDA DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 TAS spindle organization 21820309 GO:0007051 IMP mitotic spindle organization GO:0007052 IBA spindle assembly involved in female meiosis I GO:0007057 IEA mitotic nuclear division 9153231 GO:0007067 TAS mitotic centrosome separation GO:0007100 IEA anterior/posterior axis specification GO:0009948 IEA anaphase-promoting complex-dependent catabolic process GO:0031145 TAS regulation of protein stability 15987997 GO:0031647 IMP negative regulation of protein binding 21820309 GO:0032091 IDA response to estradiol GO:0032355 IEA positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IEA regulation of cytokinesis GO:0032465 IBA histone-serine phosphorylation GO:0035404 IEA protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 TAS negative regulation of apoptotic process GO:0043066 IEA positive regulation of mitotic nuclear division 19774610 GO:0045840 TAS regulation of centrosome cycle 19774610 GO:0046605 TAS protein autophosphorylation 19774610 GO:0046777 TAS cell division GO:0051301 IEA centrosome localization GO:0051642 IEA protein localization to centrosome GO:0071539 IEA positive regulation of oocyte maturation GO:1900195 IEA regulation of signal transduction by p53 class mediator GO:1901796 TAS neuron projection extension GO:1990138 IEA",protein kinase activity IDA 14580337 19801554 21600873 GO:0004672 protein serine/threonine kinase activity EXP 13678582 18566290 21807936 GO:0004674 protein serine/threonine kinase activity TAS GO:0004674 protein serine/threonine/tyrosine kinase activity TAS 19774610 GO:0004712 protein binding IPI 12244051 14580337 15987997 17726514 18521620 18662907 18663142 19111882 19801554 20360068 20596670 20643351 21821029 22014574 22306998 22340593 23520446 23792191 24857377 24996188 25175806 GO:0005515 ATP binding IEA GO:0005524 protein kinase binding IPI 18615013 GO:0019901 ubiquitin protein ligase binding IEA GO:0031625 histone serine kinase activity IBA GO:0035174,Oocyte meiosis - Homo sapiens (human) hsa04114,CHEMBL CHEMBL1243200,Q96GD4,Serine/threonine-protein kinase Aurora-B,1.0,PRIMARY,NO,CNc1nccc(n1)c2cccnc2Oc3ccc(NC(=O)c4ccccc4Nc5ccccc5)cc3,17,21,"InChI=1S/C29H24N6O2/c1-30-29-32-19-17-26(35-29)24-11-7-18-31-28(24)37-22-15-13-21(14-16-22)34-27(36)23-10-5-6-12-25(23)33-20-8-3-2-4-9-20/h2-19,33H,1H3,(H,34,36)(H,30,32,35)",YRIZEPGWRQGUBO-UHFFFAOYSA-N,"c(""Unchecked"", ""Serine/threonine-protein kinase Aurora-B"", ""Hepatocyte growth factor receptor"", ""Cyclin-dependent kinase 1"", ""Cyclin-dependent kinase 2"", ""Epidermal growth factor receptor erbB1"", ""Ephrin type-B receptor 4"", ""Insulin-like growth factor I receptor"", ""Tyrosine-protein kinase ZAP-70"", ""Tyrosine-protein kinase JAK2"", ""Tyrosine-protein kinase JAK3"", ""Tyrosine-protein kinase BTK"", ""c-Jun N-terminal kinase 2"", ""Ribosomal protein S6 kinase 1"", ""Serine/threonine-protein kinase PLK1"", ""MAP kinase ERK1"", ""Serine/threonine-protein kinase AKT"", ""Cyclin-dependent kinase 5"")",9212,AURKB,"Signal Transduction R-HSA-162582 Cell Cycle R-HSA-1640170 APC/C-mediated degradation of cell cycle proteins R-HSA-174143 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 Signaling by Rho GTPases R-HSA-194315 RHO GTPase Effectors R-HSA-195258 Separation of Sister Chromatids R-HSA-2467813 Resolution of Sister Chromatid Cohesion R-HSA-2500257 Mitotic Metaphase and Anaphase R-HSA-2555396 Regulation of mitotic cell cycle R-HSA-453276 RHO GTPases Activate Formins R-HSA-5663220 Mitotic Prometaphase R-HSA-68877 Mitotic Anaphase R-HSA-68882 M Phase R-HSA-68886 Cell Cycle, Mitotic R-HSA-69278","IDA colocalizes_with 22024163 kinetochore GO:0000776 IDA 19465021 condensed chromosome, centromeric region GO:0000779 IDA 18195732 condensed nuclear chromosome, centromeric region GO:0000780 IDA 20959462 nucleus GO:0005634 IDA GO:0005654 nucleoplasm TAS GO:0005654 nucleoplasm TAS 19774610 spindle GO:0005819 TAS GO:0005829 cytosol IBA GO:0005876 spindle microtubule IEA GO:0010369 chromocenter IDA 17726514 midbody GO:0030496 TAS 19774610 midbody GO:0030496 IBA GO:0031616 spindle pole centrosome IPI 15260989 18591255 chromosome passenger complex GO:0032133 TAS 19774610 chromosome passenger complex GO:0032133 IDA GO:0045171 intercellular bridge IBA GO:0051233 spindle midzone",negative regulation of transcription from RNA polymerase II promoter GO:0000122 20959462 IDA negative regulation of B cell apoptotic process GO:0002903 20959462 IDA protein phosphorylation GO:0006468 21820309 22724069 IDA spindle organization GO:0007051 21820309 IMP sister chromatid cohesion GO:0007062 TAS aging GO:0007568 IEA cell proliferation GO:0008283 IEA attachment of spindle microtubules to kinetochore GO:0008608 19774610 TAS abscission GO:0009838 ISS histone modification GO:0016570 19774610 TAS protein sumoylation GO:0016925 TAS anaphase-promoting complex-dependent catabolic process GO:0031145 TAS spindle checkpoint GO:0031577 IEA negative regulation of protein binding GO:0032091 21820309 IDA positive regulation of telomere maintenance via telomerase GO:0032212 21531765 IMP negative regulation of cytokinesis GO:0032466 ISS positive regulation of cytokinesis GO:0032467 16103226 IMP positive regulation of cytokinesis GO:0032467 19774610 TAS protein localization to kinetochore GO:0034501 19468067 IMP cellular response to UV GO:0034644 20959462 IDA cleavage furrow formation GO:0036089 16103226 IDA protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 TAS histone H3-S28 phosphorylation GO:0043988 ISS protein autophosphorylation GO:0046777 19774610 TAS mitotic spindle midzone assembly GO:0051256 16103226 IMP mitotic spindle midzone assembly GO:0051256 19774610 TAS positive regulation of telomerase activity GO:0051973 21531765 IMP regulation of chromosome segregation GO:0051983 19774610 TAS regulation of signal transduction by p53 class mediator GO:1901796 TAS positive regulation of telomere capping GO:1904355 21531765 IMP,21397845 GO:0004674 protein serine/threonine kinase activity EXP 22724069 GO:0004674 protein serine/threonine kinase activity IDA GO:0004674 protein serine/threonine kinase activity TAS 19774610 GO:0004712 protein serine/threonine/tyrosine kinase activity TAS 12689593 15064709 16179162 16239925 16291752 17099693 17681274 17726514 17956729 20562864 20959462 21051298 21988832 22939624 24571573 24857377 25036637 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0035174 histone serine kinase activity IBA GO:0035174 histone serine kinase activity ISS GO:0046872 metal ion binding IEA,,CHEMBL CHEMBL398606,O14757,Serine/threonine-protein kinase Chk1,1.0,ORTHOGONAL,NO,CC(C)NCc1ccc(Nc2cc([nH]n2)c3ccc(cc3)c4ccc(O)cc4O)cc1,28,33,"InChI=1S/C25H26N4O2/c1-16(2)26-15-17-3-9-20(10-4-17)27-25-14-23(28-29-25)19-7-5-18(6-8-19)22-12-11-21(30)13-24(22)31/h3-14,16,26,30-31H,15H2,1-2H3,(H2,27,28,29)",MYHOUKHXSVKHBA-UHFFFAOYSA-N,"c(""Protein kinase C zeta"", ""Inhibitor of nuclear factor kappa B kinase beta subunit"", ""Glycogen synthase kinase-3 beta"", ""Serine/threonine-protein kinase Chk1"", ""Rho-associated protein kinase 1"", ""Inhibitor of nuclear factor kappa B kinase epsilon subunit"", ""Serine/threonine-protein kinase Chk2"", ""Protein kinase C beta"", ""Cyclin-dependent kinase 2"", ""Tyrosine-protein kinase SRC"", ""Serine/threonine-protein kinase AKT"", ""MAP kinase ERK2"", ""Dual specificty protein kinase CLK1"", ""Tyrosine-protein kinase LCK"", ""Insulin receptor"", ""Epidermal growth factor receptor erbB1"", ""Serine/threonine-protein kinase PAK 4"", ""Serine/threonine-protein kinase PIM2"", ""Ribosomal protein S6 kinase 1"", ""Tyrosine-protein kinase ABL"", ""CaM kinase I alpha"", ""Serine/threonine-protein kinase Aurora-A"", ""Serine/threonine-protein kinase Sgk1"", ""Unchecked"", ""Serine/threonine-protein kinase NEK2"", ""Serine/threonine-protein kinase MST4"", ""Casein kinase I delta"", ""Cyclin-dependent kinase 1"", ""Pyruvate dehydrogenase kinase isoform 1"" )",1111,CHK1,Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Cell Cycle R-HSA-1640170 Activation of ATR in response to replication stress R-HSA-176187 G2/M DNA damage checkpoint R-HSA-69473 G2/M Checkpoints R-HSA-69481 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 p53-Independent DNA Damage Response R-HSA-69610 p53-Independent G1/S DNA damage checkpoint R-HSA-69613 G1/S DNA Damage Checkpoints R-HSA-69615 Cell Cycle Checkpoints R-HSA-69620 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035,"15149599 IDA GO:0000781 colocalizes_with chromosome, telomeric region ISS GO:0000785 chromatin 9382850 IDA GO:0000794 condensed nuclear chromosome 23580065 IDA GO:0005615 extracellular space 15311285 20932473 IDA GO:0005634 nucleus IDA GO:0005654 nucleoplasm TAS GO:0005654 nucleoplasm IEA GO:0005657 replication fork 15311285 IDA GO:0005813 centrosome TAS GO:0005829 cytosol IDA GO:0043231 intracellular membrane-bounded organelle",DNA damage checkpoint 16963448 GO:0000077 IDA DNA damage checkpoint 19716789 GO:0000077 IMP G2/M transition of mitotic cell cycle GO:0000086 IEA DNA replication GO:0006260 TAS DNA repair 19716789 GO:0006281 IMP cellular response to DNA damage stimulus 20932473 GO:0006974 IMP DNA damage induced protein phosphorylation 16963448 GO:0006975 IDA regulation of double-strand break repair via homologous recombination 15665856 GO:0010569 IDA regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage GO:0010767 ISS peptidyl-threonine phosphorylation 15665856 GO:0018107 IDA G2 DNA damage checkpoint 20932473 GO:0031572 IMP histone H3-T11 phosphorylation GO:0035407 IEA regulation of cell proliferation GO:0042127 IEA negative regulation of mitotic nuclear division 15311285 GO:0045839 IDA regulation of mitotic centrosome separation 15311285 GO:0046602 IDA chromatin-mediated maintenance of transcription GO:0048096 ISS cellular response to mechanical stimulus 19593445 GO:0071260 IEP replicative senescence 15149599 GO:0090399 NAS regulation of signal transduction by p53 class mediator GO:1901796 TAS regulation of histone H3-K9 acetylation GO:2000615 ISS,protein kinase activity IMP 22024163 GO:0004672 protein serine/threonine kinase activity IDA 16963448 GO:0004674 protein serine/threonine kinase activity TAS GO:0004674 protein binding IPI 11836499 15665856 15798197 16330544 16963448 17380128 19223857 19330022 19716789 20639859 20969866 22505024 22939624 25249323 GO:0005515 ATP binding IEA GO:0005524 kinase activity TAS GO:0016301 histone kinase activity (H3-T11 specific) IDA 18243098 GO:0035402,hsa04110 Cell cycle - Homo sapiens (human) hsa04115 p53 signaling pathway - Homo sapiens (human) hsa05166 HTLV-I infection - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human),CHEMBL CHEMBL2381116,O14757,Serine/threonine-protein kinase Chk1,1.0,PRIMARY,NO,COc1ccc2CN(C(=O)c2c1)c3nc(cs3)C(=O)Nc4cnccc4N5CCNCC5,41,44,"InChI=1S/C22H22N6O3S/c1-31-15-3-2-14-12-28(21(30)16(14)10-15)22-26-18(13-32-22)20(29)25-17-11-24-5-4-19(17)27-8-6-23-7-9-27/h2-5,10-11,13,23H,6-9,12H2,1H3,(H,25,29)",KLJVDMAOKMSBQX-UHFFFAOYSA-N,"c(""Vasopressin V2 receptor"", ""Vasopressin V1b receptor"", ""Vasopressin V1a receptor"", ""Oxytocin receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Neuropeptide Y receptor type 5"", ""Muscarinic acetylcholine receptor M5"", ""Muscarinic acetylcholine receptor M4"", ""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M1"", ""Histamine H1 receptor"", ""Dopamine D2 receptor"", ""Dopamine D1 receptor"", ""C-X-C chemokine receptor type 3"", ""Cannabinoid CB2 receptor"", ""Cannabinoid CB1 receptor"", ""Alpha-2c adrenergic receptor"", ""Alpha-2b adrenergic receptor"", ""Alpha-2a adrenergic receptor"", ""Alpha-1b adrenergic receptor"", ""Alpha-1a adrenergic receptor"", ""Testis-specific serine/threonine-protein kinase 2"", ""Ribosomal protein S6 kinase alpha 3"", ""Rho-associated protein kinase 2"", ""Serine/threonine-protein kinase PLK3"", ""Protein kinase C alpha"", ""Serine/threonine-protein kinase NEK2"", ""Serine/threonine-protein kinase MST2"", ""Hepatocyte growth factor receptor"", ""Tyrosine-protein kinase LCK"", ""Tyrosine-protein kinase JAK2"", ""Interleukin-1 receptor-associated kinase 4"", ""Inhibitor of nuclear factor kappa B kinase beta subunit"", ""Insulin-like growth factor I receptor"", ""MAP kinase ERK2"", ""Casein kinase I delta"", ""Serine/threonine-protein kinase Chk1"", ""Cyclin-dependent kinase 2"", ""CaM kinase IV"", ""Serine/threonine-protein kinase AKT"", ""Unchecked"")",1111,CHK1,Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Cell Cycle R-HSA-1640170 Activation of ATR in response to replication stress R-HSA-176187 G2/M DNA damage checkpoint R-HSA-69473 G2/M Checkpoints R-HSA-69481 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-69601 p53-Independent DNA Damage Response R-HSA-69610 p53-Independent G1/S DNA damage checkpoint R-HSA-69613 G1/S DNA Damage Checkpoints R-HSA-69615 Cell Cycle Checkpoints R-HSA-69620 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex R-HSA-75035,"15149599 IDA GO:0000781 colocalizes_with chromosome, telomeric region ISS GO:0000785 chromatin 9382850 IDA GO:0000794 condensed nuclear chromosome 23580065 IDA GO:0005615 extracellular space 15311285 20932473 IDA GO:0005634 nucleus IDA GO:0005654 nucleoplasm TAS GO:0005654 nucleoplasm IEA GO:0005657 replication fork 15311285 IDA GO:0005813 centrosome TAS GO:0005829 cytosol IDA GO:0043231 intracellular membrane-bounded organelle",DNA damage checkpoint 16963448 GO:0000077 IDA DNA damage checkpoint 19716789 GO:0000077 IMP G2/M transition of mitotic cell cycle GO:0000086 IEA DNA replication GO:0006260 TAS DNA repair 19716789 GO:0006281 IMP cellular response to DNA damage stimulus 20932473 GO:0006974 IMP DNA damage induced protein phosphorylation 16963448 GO:0006975 IDA regulation of double-strand break repair via homologous recombination 15665856 GO:0010569 IDA regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage GO:0010767 ISS peptidyl-threonine phosphorylation 15665856 GO:0018107 IDA G2 DNA damage checkpoint 20932473 GO:0031572 IMP histone H3-T11 phosphorylation GO:0035407 IEA regulation of cell proliferation GO:0042127 IEA negative regulation of mitotic nuclear division 15311285 GO:0045839 IDA regulation of mitotic centrosome separation 15311285 GO:0046602 IDA chromatin-mediated maintenance of transcription GO:0048096 ISS cellular response to mechanical stimulus 19593445 GO:0071260 IEP replicative senescence 15149599 GO:0090399 NAS regulation of signal transduction by p53 class mediator GO:1901796 TAS regulation of histone H3-K9 acetylation GO:2000615 ISS,protein kinase activity IMP 22024163 GO:0004672 protein serine/threonine kinase activity IDA 16963448 GO:0004674 protein serine/threonine kinase activity TAS GO:0004674 protein binding IPI 11836499 15665856 15798197 16330544 16963448 17380128 19223857 19330022 19716789 20639859 20969866 22505024 22939624 25249323 GO:0005515 ATP binding IEA GO:0005524 kinase activity TAS GO:0016301 histone kinase activity (H3-T11 specific) IDA 18243098 GO:0035402,hsa04110 Cell cycle - Homo sapiens (human) hsa04115 p53 signaling pathway - Homo sapiens (human) hsa05166 HTLV-I infection - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human),CHEMBL CHEMBL3609300,P53350,Serine/threonine-protein kinase PLK1,1.0,PRIMARY,NO,CC[C@H]1N(C2CCCC2)c3nc(Nc4ccc(cc4OC)C(=O)NC5CCN(C)CC5)ncc3N(CC)C1=O,2,3,"InChI=1S/C29H41N7O3/c1-5-23-28(38)35(6-2)24-18-30-29(33-26(24)36(23)21-9-7-8-10-21)32-22-12-11-19(17-25(22)39-4)27(37)31-20-13-15-34(3)16-14-20/h11-12,17-18,20-21,23H,5-10,13-16H2,1-4H3,(H,31,37)(H,30,32,33)/t23-/m1/s1",KHVSTZSCKUIMFH-HSZRJFAPSA-N,"c(""Bromodomain-containing protein 4"", ""Serine/threonine-protein kinase PLK1"", ""MV4-11"")",5347,PLK1,"Polo-like kinase mediated events R-HSA-156711 Signal Transduction R-HSA-162582 Golgi Cisternae Pericentriolar Stack Reorganization R-HSA-162658 Cell Cycle R-HSA-1640170 APC/C-mediated degradation of cell cycle proteins R-HSA-174143 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174178 Regulation of APC/C activators between G1/S and early anaphase R-HSA-176408 Phosphorylation of the APC/C R-HSA-176412 Phosphorylation of Emi1 R-HSA-176417 Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins R-HSA-176814 Organelle biogenesis and maintenance R-HSA-1852241 Signaling by Rho GTPases R-HSA-194315 RHO GTPase Effectors R-HSA-195258 Condensation of Prophase Chromosomes R-HSA-2299718 Separation of Sister Chromatids R-HSA-2467813 Resolution of Sister Chromatid Cohesion R-HSA-2500257 Mitotic Metaphase and Anaphase R-HSA-2555396 Regulation of PLK1 Activity at G2/M Transition R-HSA-2565942 Nuclear Envelope Breakdown R-HSA-2980766 Activation of NIMA Kinases NEK9, NEK6, NEK7 R-HSA-2980767 Loss of Nlp from mitotic centrosomes R-HSA-380259 Recruitment of mitotic centrosome proteins and complexes R-HSA-380270 Loss of proteins required for interphase microtubule organizationfrom the centrosome R-HSA-380284 Centrosome maturation R-HSA-380287 Mitotic G2-G2/M phases R-HSA-453274 Regulation of mitotic cell cycle R-HSA-453276 Assembly of the primary cilium R-HSA-5617833 Anchoring of the basal body to the plasma membrane R-HSA-5620912 RHO GTPases Activate Formins R-HSA-5663220 Mitotic Prophase R-HSA-68875 Mitotic Prometaphase R-HSA-68877 Mitotic Metaphase/Anaphase Transition R-HSA-68881 Mitotic Anaphase R-HSA-68882 Mitotic Telophase/Cytokinesis R-HSA-68884 M Phase R-HSA-68886 Cyclin A/B1 associated events during G2/M transition R-HSA-69273 G2/M Transition R-HSA-69275 Cell Cycle, Mitotic R-HSA-69278",GO:0000776 kinetochore 17617734 18477460 18615013 21041660 23455478 IDA GO:0000785 chromatin IEA GO:0000795 synaptonemal complex IEA GO:0000922 spindle pole 18331714 21041660 IDA GO:0000942 condensed nuclear chromosome outer kinetochore 18195732 IDA GO:0005634 nucleus 18615013 IDA GO:0005654 nucleoplasm TAS GO:0005730 nucleolus IDA GO:0005737 cytoplasm IDA GO:0005813 centrosome 8991084 12524548 18477460 18615013 21041660 21399614 23455478 IDA GO:0005819 spindle 12939256 17351640 IDA GO:0005829 cytosol TAS GO:0005876 spindle microtubule colocalizes_with 21041660 IDA GO:0015630 microtubule cytoskeleton 21041660 IDA GO:0030496 midbody 19468300 IDA GO:0051233 spindle midzone 19468302 21041660 IDA,mitotic sister chromatid segregation GO:0000070 23455478 IMP G2/M transition of mitotic cell cycle GO:0000086 19160488 IDA G2/M transition of mitotic cell cycle GO:0000086 TAS negative regulation of transcription from RNA polymerase II promoter GO:0000122 18174154 IMP mitotic cytokinesis GO:0000281 19468302 IDA cytokinesis GO:0000910 17351640 IDA cytokinesis GO:0000910 12939256 IMP microtubule bundle formation GO:0001578 12939256 IDA protein phosphorylation GO:0006468 19468300 22701722 IDA sister chromatid cohesion GO:0007062 TAS mitotic nuclear division GO:0007067 18615013 IDA mitotic nuclear division GO:0007067 18477460 IMP mitotic nuclear envelope disassembly GO:0007077 TAS mitotic spindle assembly checkpoint GO:0007094 23455478 IMP regulation of mitotic cell cycle GO:0007346 17495026 IMP cell proliferation GO:0008283 8127874 TAS positive regulation of peptidyl-threonine phosphorylation GO:0010800 21041660 IMP female meiosis chromosome segregation GO:0016321 IEA protein ubiquitination GO:0016567 16885022 IDA peptidyl-serine phosphorylation GO:0018105 16885022 IDA regulation of mitotic metaphase/anaphase transition GO:0030071 21041660 IMP anaphase-promoting complex-dependent catabolic process GO:0031145 TAS G2 DNA damage checkpoint GO:0031572 18662541 IDA protein destabilization GO:0031648 16885022 IDA positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 19473992 IMP protein ubiquitination involved in ubiquitin-dependent protein catabolic process GO:0042787 TAS negative regulation of apoptotic process GO:0043066 18174154 IMP regulation of protein binding GO:0043393 21041660 IMP homologous chromosome segregation GO:0045143 IEA establishment of protein localization GO:0045184 18331714 IMP negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045736 21041660 IMP positive regulation of proteolysis GO:0045862 16885022 IDA centrosome organization GO:0051297 8991084 18477460 IMP positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition GO:0051437 TAS regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle GO:0051439 TAS positive regulation of ubiquitin-protein transferase activity GO:0051443 19473992 IMP regulation of cell cycle GO:0051726 TAS synaptonemal complex disassembly GO:0070194 IEA protein localization to chromatin GO:0071168 21111234 IDA positive regulation of protein localization to nucleus GO:1900182 TAS regulation of mitotic spindle assembly GO:1901673 22621898 IDA regulation of cell cycle G2/M phase transition GO:1902749 TAS positive regulation of ubiquitin protein ligase activity GO:1904668 15148369 IDA,protein kinase activity GO:0004672 17146433 19596235 22854038 IDA protein serine/threonine kinase activity GO:0004674 18378770 20577264 EXP protein serine/threonine kinase activity GO:0004674 12524548 12939256 15148369 17351640 18174154 18477460 19160488 19468300 19468302 IDA protein serine/threonine kinase activity GO:0004674 19473992 21041660 23455478 IMP protein serine/threonine kinase activity GO:0004674 TAS protein binding GO:0005515 12493754 12524548 12939256 15148369 15654075 16439210 16753148 16760428 16980960 17146433 17310276 17351640 17495026 18174154 18329369 18331714 18477460 18521620 18615013 19160488 19468300 19468302 19473992 19596235 19833129 20360068 20534861 20577264 20890306 21642957 21887822 21988832 22609948 22653443 23455478 25852190 26496610 26638075 IPI ATP binding GO:0005524 IEA microtubule binding GO:0008017 12939256 IDA anaphase-promoting complex binding GO:0010997 18662541 IPI kinase activity GO:0016301 TAS protein kinase binding GO:0019901 12639966 18615013 21041660 IPI,hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04110 Cell cycle - Homo sapiens (human) hsa04114 Oocyte meiosis - Homo sapiens (human) hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human),CHEMBL CHEMBL3092468,O00141,Serine/threonine-protein kinase Sgk1,1.0,PRIMARY,NO,Nc1n[nH]c2nc(cnc12)c3ccc(NS(=O)(=O)c4cc(Cl)ccc4F)cc3,3,8,"InChI=1S/C17H12ClFN6O2S/c18-10-3-6-12(19)14(7-10)28(26,27)25-11-4-1-9(2-5-11)13-8-21-15-16(20)23-24-17(15)22-13/h1-8,25H,(H3,20,22,23,24)",DDKHTWASHUKHLD-UHFFFAOYSA-N,"c(""Serine/threonine-protein kinase Sgk1"", ""Serine/threonine-protein kinase Sgk2"", ""Serine/threonine-protein kinase Sgk3"", ""AMP-activated protein kinase, AMPK"")",6446,SGK1,R-HSA-2672351 Stimuli-sensing channels R-HSA-382551 Transmembrane transport of small molecules R-HSA-983712 Ion channel transport,IBA GO:0005634 nucleus IDA GO:0005654 nucleoplasm IBA GO:0005737 cytoplasm IDA GO:0005737 cytoplasm IEA GO:0005739 mitochondrion IEA GO:0005789 endoplasmic reticulum membrane TAS GO:0005829 cytosol IEA GO:0005886 plasma membrane IEA GO:0043005 neuron projection IEA GO:0048471 perinuclear region of cytoplasm,regulation of cell growth 20919962 GO:0001558 TAS protein phosphorylation 9114008 GO:0006468 TAS sodium ion transport 10884438 GO:0006814 TAS cellular sodium ion homeostasis GO:0006883 IBA apoptotic process GO:0006915 IEA response to stress 9114008 GO:0006950 TAS cellular response to DNA damage stimulus GO:0006974 IEA microtubule depolymerization GO:0007019 IEA long-term memory 20530112 GO:0007616 TAS regulation of blood pressure 16460280 GO:0008217 TAS visual learning GO:0008542 IEA positive regulation of sodium ion transport GO:0010765 IBA peptidyl-serine phosphorylation GO:0018105 IBA positive regulation of cell growth GO:0030307 IEA regulation of cell migration 20919962 GO:0030334 TAS negative regulation of microtubule polymerization GO:0031115 IEA positive regulation of transporter activity 20530112 GO:0032411 TAS ion transmembrane transport GO:0034220 TAS intracellular signal transduction GO:0035556 IBA regulation of cell proliferation 20530112 GO:0042127 TAS regulation of apoptotic process 20530112 GO:0042981 TAS negative regulation of apoptotic process GO:0043066 IEA glucocorticoid mediated signaling pathway GO:0043402 IEA neuron projection morphogenesis GO:0048812 IBA positive regulation of dendrite morphogenesis GO:0050775 IEA regulation of catalytic activity 20530112 GO:0050790 TAS regulation of sequence-specific DNA binding transcription factor activity 20530112 GO:0051090 TAS regulation of cell cycle GO:0051726 IEA regulation of gastric acid secretion 20530112 GO:0060453 TAS renal sodium ion absorption 16460280 GO:0070294 TAS,protein serine/threonine kinase activity GO:0004674 TAS protein serine/threonine/tyrosine kinase activity 22797923 GO:0004712 IDA calcium channel regulator activity 20530112 GO:0005246 TAS protein binding 20237237 GO:0005515 IPI ATP binding GO:0005524 IEA potassium channel regulator activity 20530112 GO:0015459 TAS sodium channel regulator activity 20530112 GO:0017080 TAS chloride channel regulator activity 20530112 GO:0017081 TAS 3-phosphoinositide-dependent protein kinase binding GO:0043423 IEA cofactor binding GO:0048037 IEA tau protein binding GO:0048156 IEA,hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human),CHEMBL CHEMBL2158866,Q96Q15,Serine/threonine-protein kinase SMG1,1.0,PRIMARY,NO,CCN(CC)S(=O)(=O)c1cc(Nc2nccc(n2)c3ccnc(c3)c4ccc(NC(=O)NC)cc4)ccc1Cl,8,10,"InChI=1S/C27H28ClN7O3S/c1-4-35(5-2)39(37,38)25-17-21(10-11-22(25)28)32-26-31-15-13-23(34-26)19-12-14-30-24(16-19)18-6-8-20(9-7-18)33-27(36)29-3/h6-17H,4-5H2,1-3H3,(H2,29,33,36)(H,31,32,34)",RZFJBSIAXYEPBX-UHFFFAOYSA-N,"c(""MDA-MB-468"", ""Unchecked"", ""Glycogen synthase kinase-3 beta"", ""Glycogen synthase kinase-3 alpha"", ""Cyclin-dependent kinase 1"", ""Cyclin-dependent kinase 2"", ""PI3-kinase p110-alpha subunit"", ""PI3-kinase p110-gamma subunit"", ""Serine/threonine-protein kinase mTOR"", ""Serine/threonine-protein kinase SMG1"")",23049,SMG1,Gene Expression R-HSA-74160 Nonsense-Mediated Decay (NMD) R-HSA-927802 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) R-HSA-975957,14636577 15175154 IDA GO:0005634 nucleus 14636577 15175154 IDA GO:0005737 cytoplasm TAS GO:0005829 cytosol,"11544179 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IDA 11331269 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay NAS 16488880 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS 17916692 GO:0000723 telomere maintenance IMP GO:0006281 DNA repair IBA 16488880 GO:0006406 mRNA export from nucleus TAS 15175154 GO:0006950 response to stress IDA 11544179 15175154 GO:0018105 peptidyl-serine phosphorylation IDA 14636577 GO:0018105 peptidyl-serine phosphorylation TAS 11331269 11544179 GO:0046777 protein autophosphorylation IDA 11331269 GO:0046854 phosphatidylinositol phosphorylation IDA",14636577 GO:0004672 protein kinase activity TAS 11544179 GO:0004674 protein serine/threonine kinase activity EXP 11544179 15175154 19417104 GO:0004674 protein serine/threonine kinase activity IDA 11331269 GO:0004674 protein serine/threonine kinase activity NAS 11544179 16452507 18256688 19417104 20371770 20864032 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA 17916692 GO:0042162 telomeric DNA binding IDA 22681889 GO:0044822 poly(A) RNA binding IDA GO:0046872 metal ion binding IEA,hsa03015 mRNA surveillance pathway - Homo sapiens (human),CHEMBL CHEMBL1774995,P08908,Serotonin 1a (5-HT1a) receptor,1.0,ORTHOGONAL,NO,Oc1ccccc1N2CCN(CCN(C(=O)C34C5C6C3C7C4C5C67I)c8ccccn8)CC2,23,26,"InChI=1S/C26H27IN4O2/c27-26-21-18-22(26)20-23(26)19(21)25(18,20)24(33)31(17-7-3-4-8-28-17)14-11-29-9-12-30(13-10-29)15-5-1-2-6-16(15)32/h1-8,18-23,32H,9-14H2",IUEHDTRLKKNLDW-UHFFFAOYSA-N,"c(""Dopamine D2 receptor"", ""Beta-3 adrenergic receptor"", ""Beta-2 adrenergic receptor"", ""Beta-1 adrenergic receptor"", ""Alpha-2c adrenergic receptor"", ""Serotonin 5a (5-HT5a) receptor"", ""Serotonin 1d (5-HT1d) receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Dopamine D4 receptor"", ""Alpha-1d adrenergic receptor"", ""Alpha-1b adrenergic receptor"", ""Alpha-1a adrenergic receptor"", ""Serotonin 7 (5-HT7) receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Unchecked"", ""Sigma opioid receptor"", ""Serotonin transporter"", ""Alpha-2b adrenergic receptor"", ""Alpha-2a adrenergic receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Serotonin 3a (5-HT3a) receptor"", ""Serotonin 2c (5-HT2c) receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 1e (5-HT1e) receptor"")",3350,5HT1A,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375280 Amine ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-390666 Serotonin receptors R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 22957663 IDA,behavioral fear response ISS GO:0001662 G-protein coupled receptor signaling pathway IMP 22957663 GO:0007186 adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA 8393041 GO:0007198 serotonin receptor signaling pathway ISS GO:0007210 cell proliferation IEA GO:0008283 positive regulation of cell proliferation TAS 1330092 GO:0008284 regulation of serotonin secretion ISS GO:0014062 exploration behavior ISS GO:0035640 regulation of dopamine metabolic process ISS GO:0042053 vasoconstriction IEA GO:0042310 serotonin metabolic process ISS GO:0042428 regulation of hormone secretion IEA GO:0046883 regulation of behavior IEA GO:0050795,G-protein coupled serotonin receptor activity IDA 8393041 GO:0004993 G-protein coupled serotonin receptor activity IMP 22957663 GO:0004993 protein binding IPI 22035699 GO:0005515,cAMP signaling pathway - Homo sapiens (human) hsa04024 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Serotonergic synapse - Homo sapiens (human) hsa04726,CHEMBL CHEMBL2164354,P08908,Serotonin 1a (5-HT1a) receptor,1.0,PRIMARY,NO,O=C(C1CCCCC1)N(CCN2CCC(=CC2)c3ccccc3)c4ccccn4,31,46,"InChI=1S/C25H31N3O/c29-25(23-11-5-2-6-12-23)28(24-13-7-8-16-26-24)20-19-27-17-14-22(15-18-27)21-9-3-1-4-10-21/h1,3-4,7-10,13-14,16,23H,2,5-6,11-12,15,17-20H2",YUOLKUGHNOWKJF-UHFFFAOYSA-N,"c(""Unchecked"", ""Sigma opioid receptor"", ""Dopamine D3 receptor"", ""Dopamine D2 receptor"", ""Muscarinic acetylcholine receptor M5"", ""Muscarinic acetylcholine receptor M4"", ""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M1"", ""Histamine H3 receptor"", ""Dopamine transporter"", ""Dopamine D5 receptor"", ""Dopamine D1 receptor"", ""Beta-3 adrenergic receptor"", ""Beta-1 adrenergic receptor"", ""Beta-2 adrenergic receptor"", ""Alpha-2b adrenergic receptor"", ""Alpha-2a adrenergic receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Serotonin 5a (5-HT5a) receptor"", ""Serotonin 3a (5-HT3a) receptor"", ""Serotonin 2c (5-HT2c) receptor"", ""Serotonin 1d (5-HT1d) receptor"", ""Serotonin 1e (5-HT1e) receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Dopamine D4 receptor"", ""Alpha-1b adrenergic receptor"", ""Alpha-1a adrenergic receptor"", ""Serotonin 7 (5-HT7) receptor"", ""Serotonin 2b (5-HT2b) receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 1a (5-HT1a) receptor"")",3350,5HT1A,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375280 Amine ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-390666 Serotonin receptors R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 22957663 IDA,behavioral fear response ISS GO:0001662 G-protein coupled receptor signaling pathway IMP 22957663 GO:0007186 adenylate cyclase-inhibiting serotonin receptor signaling pathway IDA 8393041 GO:0007198 serotonin receptor signaling pathway ISS GO:0007210 cell proliferation IEA GO:0008283 positive regulation of cell proliferation TAS 1330092 GO:0008284 regulation of serotonin secretion ISS GO:0014062 exploration behavior ISS GO:0035640 regulation of dopamine metabolic process ISS GO:0042053 vasoconstriction IEA GO:0042310 serotonin metabolic process ISS GO:0042428 regulation of hormone secretion IEA GO:0046883 regulation of behavior IEA GO:0050795,G-protein coupled serotonin receptor activity IDA 8393041 GO:0004993 G-protein coupled serotonin receptor activity IMP 22957663 GO:0004993 protein binding IPI 22035699 GO:0005515,cAMP signaling pathway - Homo sapiens (human) hsa04024 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Serotonergic synapse - Homo sapiens (human) hsa04726,CHEMBL CHEMBL425190,P28221,Serotonin 1d (5-HT1d) receptor,1.0,PRIMARY,NO,Cc1ccc2c(OCCN3CCN(Cc4cccc5cccnc45)CC3)cccc2n1,17,22,"InChI=1S/C26H28N4O/c1-20-10-11-23-24(28-20)8-3-9-25(23)31-18-17-29-13-15-30(16-14-29)19-22-6-2-5-21-7-4-12-27-26(21)22/h2-12H,13-19H2,1H3",RMCSKUADBRROSI-UHFFFAOYSA-N,"c(""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 2c (5-HT2c) receptor"", ""Serotonin 4 (5-HT4) receptor"", ""Serotonin 5a (5-HT5a) receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Serotonin 7 (5-HT7) receptor"", ""Alpha-1b adrenergic receptor"", ""Beta-2 adrenergic receptor"", ""Dopamine D2 receptor"", ""Dopamine D3 receptor"", ""Dopamine D4 receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Serotonin 1d (5-HT1d) receptor"", ""Serotonin 1 receptors; 5-HT1B & 5-HT1D"", ""Serotonin 1e (5-HT1e) receptor"", ""Serotonin 1f (5-HT1f) receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 2b (5-HT2b) receptor"")",3352,5HT1D,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Amine ligand-binding receptors R-HSA-375280 GPCR downstream signaling R-HSA-388396 Serotonin receptors R-HSA-390666 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,plasma membrane GO:0005886 TAS integral component of plasma membrane 1652050 GO:0005887 IDA,"GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 1565658 TAS GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway 1652050 IMP GO:0007210 serotonin receptor signaling pathway IEA GO:0007268 chemical synaptic transmission IEA GO:0009636 response to toxic substance IEA GO:0014827 intestine smooth muscle contraction 9186750 IMP GO:0040012 regulation of locomotion IEA GO:0042310 vasoconstriction IEA GO:0050795 regulation of behavior IEA",GO:0004993 G-protein coupled serotonin receptor activity 1652050 IMP GO:0051378 serotonin binding IEA,hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04726 Serotonergic synapse - Homo sapiens (human),CHEMBL CHEMBL3617550,P30939,Serotonin 1f (5-HT1f) receptor,1.0,PRIMARY,YES,CN1CCC(CC1)C(=O)c2cccc(NC(=O)c3ccc(F)cc3)c2F,4,6,"InChI=1S/C20H20F2N2O2/c1-24-11-9-13(10-12-24)19(25)16-3-2-4-17(18(16)22)23-20(26)14-5-7-15(21)8-6-14/h2-8,13H,9-12H2,1H3,(H,23,26)",SGSLWTIFTLMNRI-UHFFFAOYSA-N,"c(""Serotonin 1f (5-HT1f) receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Serotonin 1d (5-HT1d) receptor"")",3355,5HT1F,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Amine ligand-binding receptors R-HSA-375280 GPCR downstream signaling R-HSA-388396 Serotonin receptors R-HSA-390666 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,GO:0005886 plasma membrane TAS 21422162 GO:0005887 integral component of plasma membrane IMP,"G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 TAS 8380639 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 IMP 21422162 serotonin receptor signaling pathway GO:0007210 IEA chemical synaptic transmission GO:0007268 TAS 8380639",G-protein coupled serotonin receptor activity GO:0004993 8380639 IDA G-protein coupled serotonin receptor activity GO:0004993 21422162 IMP serotonin binding GO:0051378 8380639 IDA,cAMP signaling pathway - Homo sapiens (human) hsa04024 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Serotonergic synapse - Homo sapiens (human) hsa04726,CHEMBL CHEMBL570274,P28335,Serotonin 2c (5-HT2c) receptor,1.0,ORTHOGONAL,YES,C[C@@H]1CNCCN1C2=NN(CCOc3ccccc3C(F)(F)F)C(=O)C=C2,5,13,"InChI=1S/C18H21F3N4O2/c1-13-12-22-8-9-24(13)16-6-7-17(26)25(23-16)10-11-27-15-5-3-2-4-14(15)18(19,20)21/h2-7,13,22H,8-12H2,1H3/t13-/m1/s1",RUBIIBKQQMGNHO-CYBMUJFWSA-N,"c(""Serotonin 2c (5-HT2c) receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 2b (5-HT2b) receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Serotonin 1d (5-HT1d) receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Bradykinin B2 receptor"", ""GABA-A receptor; agonist GABA site"")",3358,5HT2C,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375280 Amine ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-390666 Serotonin receptors R-HSA-416476 G alpha (q) signalling events R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,cytosol IEA GO:0005829 plasma membrane IDA 12970106 18703043 GO:0005886 plasma membrane TAS GO:0005886 integral component of plasma membrane IMP 18703043 GO:0005887,ISS GO:0001662 behavioral fear response IDA 12970106 cGMP biosynthetic process GO:0006182 IDA 19057895 cellular calcium ion homeostasis GO:0006874 IDA 12970106 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 ISS GO:0007208 phospholipase C-activating serotonin receptor signaling pathway IMP 18703043 serotonin receptor signaling pathway GO:0007210 TAS 9241279 chemical synaptic transmission GO:0007268 IEA GO:0007626 locomotory behavior ISS GO:0007631 feeding behavior IDA 19057895 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 ISS GO:0031644 regulation of neurological system process ISS GO:0032098 regulation of appetite IDA 18703043 response to drug GO:0042493 ISS GO:0043397 regulation of corticotropin-releasing hormone secretion IEA GO:0045600 positive regulation of fat cell differentiation IMP 18703043 release of sequestered calcium ion into cytosol GO:0051209 ISS GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IDA 19057895 positive regulation of ERK1 and ERK2 cascade GO:0070374,"Gq/11-coupled serotonin receptor activity 18703043 GO:0001587 IDA G-protein coupled serotonin receptor activity 7582481 GO:0004993 IDA drug binding 12970106 15831837 18703043 GO:0008144 IDA serotonin binding 7582481 15831837 19057895 GO:0051378 IDA 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding 19057895 GO:0071886 IDA",Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Gap junction - Homo sapiens (human) hsa04540 Serotonergic synapse - Homo sapiens (human) hsa04726 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04750,CHEMBL CHEMBL3416063,P28335,Serotonin 2c (5-HT2c) receptor,1.0,PRIMARY,YES,Cl.NC[C@H]1C[C@@H]1c2cc(F)ccc2OCC=C,9,12,"InChI=1S/C13H16FNO.ClH/c1-2-5-16-13-4-3-10(14)7-12(13)11-6-9(11)8-15;/h2-4,7,9,11H,1,5-6,8,15H2;1H/t9-,11+;/m1./s1",MNIAWGCBQVLINM-XQKZEKTMSA-N,"c(""Serotonin 2c (5-HT2c) receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Serotonin 7 (5-HT7) receptor"", ""Alpha-2a adrenergic receptor"", ""Alpha-2b adrenergic receptor"", ""Alpha-2c adrenergic receptor"", ""Dopamine D3 receptor"", ""Unchecked"")",3358,5HT2C,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375280 Amine ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-390666 Serotonin receptors R-HSA-416476 G alpha (q) signalling events R-HSA-500792 GPCR ligand binding R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK,cytosol IEA GO:0005829 plasma membrane IDA 12970106 18703043 GO:0005886 plasma membrane TAS GO:0005886 integral component of plasma membrane IMP 18703043 GO:0005887,ISS GO:0001662 behavioral fear response IDA 12970106 cGMP biosynthetic process GO:0006182 IDA 19057895 cellular calcium ion homeostasis GO:0006874 IDA 12970106 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007200 ISS GO:0007208 phospholipase C-activating serotonin receptor signaling pathway IMP 18703043 serotonin receptor signaling pathway GO:0007210 TAS 9241279 chemical synaptic transmission GO:0007268 IEA GO:0007626 locomotory behavior ISS GO:0007631 feeding behavior IDA 19057895 positive regulation of phosphatidylinositol biosynthetic process GO:0010513 ISS GO:0031644 regulation of neurological system process ISS GO:0032098 regulation of appetite IDA 18703043 response to drug GO:0042493 ISS GO:0043397 regulation of corticotropin-releasing hormone secretion IEA GO:0045600 positive regulation of fat cell differentiation IMP 18703043 release of sequestered calcium ion into cytosol GO:0051209 ISS GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IDA 19057895 positive regulation of ERK1 and ERK2 cascade GO:0070374,"Gq/11-coupled serotonin receptor activity 18703043 GO:0001587 IDA G-protein coupled serotonin receptor activity 7582481 GO:0004993 IDA drug binding 12970106 15831837 18703043 GO:0008144 IDA serotonin binding 7582481 15831837 19057895 GO:0051378 IDA 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding 19057895 GO:0071886 IDA",Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Gap junction - Homo sapiens (human) hsa04540 Serotonergic synapse - Homo sapiens (human) hsa04726 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04750,CHEMBL CHEMBL1258452,Q13639,Serotonin 4 (5-HT4) receptor,1.0,ORTHOGONAL,NO,CCCCN1CCC(COC(=O)c2ccc(N)c(OC)c2)CC1,30,47,"InChI=1S/C18H28N2O3/c1-3-4-9-20-10-7-14(8-11-20)13-23-18(21)15-5-6-16(19)17(12-15)22-2/h5-6,12,14H,3-4,7-11,13,19H2,1-2H3",DZZIAERGLDKTBT-UHFFFAOYSA-N,"c(""Unchecked"", ""Serotonin 4 (5-HT4) receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Serotonin 1d (5-HT1d) receptor"", ""Serotonin 1e (5-HT1e) receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 2b (5-HT2b) receptor"", ""Serotonin 2c (5-HT2c) receptor"", ""Serotonin 3a (5-HT3a) receptor"", ""Serotonin 5a (5-HT5a) receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Serotonin 7 (5-HT7) receptor"", ""Serotonin transporter"", ""Alpha-1a adrenergic receptor"", ""Alpha-1d adrenergic receptor"", ""Alpha-1b adrenergic receptor"", ""Alpha-2a adrenergic receptor"", ""Alpha-2b adrenergic receptor"", ""Alpha-2c adrenergic receptor"", ""Dopamine transporter"", ""Delta opioid receptor"", ""Dopamine D5 receptor"", ""GABA-A receptor; agonist GABA site"", ""Kappa opioid receptor"", ""Muscarinic acetylcholine receptor M1"", ""Mu opioid receptor"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M4"", ""Muscarinic acetylcholine receptor M5"", ""Norepinephrine transporter"" )",3360,5HT4R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Amine ligand-binding receptors R-HSA-375280 GPCR downstream signaling R-HSA-388396 Serotonin receptors R-HSA-390666 G alpha (s) signalling events R-HSA-418555 GPCR ligand binding R-HSA-500792,GO:0005737 cytoplasm 15925089 IDA GO:0005768 endosome IEA GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane IEA GO:0016020 membrane 16102731 IDA,"9351641 TAS GO:0007186 G-protein coupled receptor signaling pathway 9603189 TAS GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA GO:0007210 serotonin receptor signaling pathway IBA GO:0007214 gamma-aminobutyric acid signaling pathway IEA GO:0007268 chemical synaptic transmission IEA GO:0032098 regulation of appetite",16102731 GO:0004993 G-protein coupled serotonin receptor activity IDA,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04726 Serotonergic synapse - Homo sapiens (human),CHEMBL CHEMBL1632158,Q13639,Serotonin 4 (5-HT4) receptor,1.0,PRIMARY,NO,COC(=O)CCCCCN1CCC(CNC(=O)c2c3OCCCn3c4ccccc24)CC1,41,45,"InChI=1S/C25H35N3O4/c1-31-22(29)10-3-2-6-13-27-15-11-19(12-16-27)18-26-24(30)23-20-8-4-5-9-21(20)28-14-7-17-32-25(23)28/h4-5,8-9,19H,2-3,6-7,10-18H2,1H3,(H,26,30)",RNXYMZNGMNWKMC-UHFFFAOYSA-N,"c(""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 1d (5-HT1d) receptor"", ""Histamine H2 receptor"", ""Serotonin 3a (5-HT3a) receptor"", ""Muscarinic acetylcholine receptor M2"", ""Alpha-2b adrenergic receptor"", ""Histamine H1 receptor"", ""Sigma opioid receptor"", ""Serotonin 2b (5-HT2b) receptor"", ""Serotonin 4 (5-HT4) receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Serotonin 1e (5-HT1e) receptor"", ""Serotonin 2c (5-HT2c) receptor"", ""Serotonin 5a (5-HT5a) receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Serotonin 7 (5-HT7) receptor"", ""Alpha-1a adrenergic receptor"", ""Alpha-1b adrenergic receptor"", ""Alpha-1d adrenergic receptor"", ""Alpha-2a adrenergic receptor"", ""Alpha-2c adrenergic receptor"", ""Beta-1 adrenergic receptor"", ""Beta-2 adrenergic receptor"", ""Beta-3 adrenergic receptor"", ""Dopamine D1 receptor"", ""Dopamine D2 receptor"", ""Dopamine D3 receptor"", ""Dopamine D4 receptor"", ""Dopamine D5 receptor"", ""Histamine H3 receptor"", ""Histamine H4 receptor"", ""Muscarinic acetylcholine receptor M1"", ""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M4"", ""Muscarinic acetylcholine receptor M5"", ""Delta opioid receptor"", ""Kappa opioid receptor"", ""Mu opioid receptor"", ""Unchecked"", ""Dopamine transporter"", ""Serotonin transporter"")",3360,5HT4R,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Amine ligand-binding receptors R-HSA-375280 GPCR downstream signaling R-HSA-388396 Serotonin receptors R-HSA-390666 G alpha (s) signalling events R-HSA-418555 GPCR ligand binding R-HSA-500792,GO:0005737 cytoplasm 15925089 IDA GO:0005768 endosome IEA GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane IEA GO:0016020 membrane 16102731 IDA,"9351641 TAS GO:0007186 G-protein coupled receptor signaling pathway 9603189 TAS GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IEA GO:0007210 serotonin receptor signaling pathway IBA GO:0007214 gamma-aminobutyric acid signaling pathway IEA GO:0007268 chemical synaptic transmission IEA GO:0032098 regulation of appetite",16102731 GO:0004993 G-protein coupled serotonin receptor activity IDA,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04726 Serotonergic synapse - Homo sapiens (human),CHEMBL CHEMBL191460,P47898,Serotonin 5a (5-HT5a) receptor,1.0,PRIMARY,NO,CN(C)CCN(Cc1ccc(cc1)c2ccc(CNCCc3ccccc3)cc2)C(=O)CCC4CCCC4.OC(=O)C(F)(F)F.OC(=O)C(F)(F)F,15,15,"InChI=1S/C34H45N3O.2C2HF3O2/c1-36(2)24-25-37(34(38)21-16-28-10-6-7-11-28)27-31-14-19-33(20-15-31)32-17-12-30(13-18-32)26-35-23-22-29-8-4-3-5-9-29;2*3-2(4,5)1(6)7/h3-5,8-9,12-15,17-20,28,35H,6-7,10-11,16,21-27H2,1-2H3;2*(H,6,7)",GQTXLMGFFOLOLU-UHFFFAOYSA-N,"c(""Serotonin 5a (5-HT5a) receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Serotonin 7 (5-HT7) receptor"", ""Dopamine D2 receptor"", ""Dopamine D3 receptor"", ""Dopamine D4 receptor"", ""Alpha-1b adrenergic receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Serotonin 1d (5-HT1d) receptor"", ""Serotonin 1e (5-HT1e) receptor"", ""Serotonin 1f (5-HT1f) receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 2b (5-HT2b) receptor"", ""Serotonin 2c (5-HT2c) receptor"")",3361,5HT5A,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375280 Amine ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-390666 Serotonin receptors R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,rough endoplasmic reticulum GO:0005791 IEA Golgi apparatus GO:0005794 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 IEA dendrite GO:0030425 IEA perikaryon GO:0043204 IEA,"G-protein coupled receptor signaling pathway GO:0007186 7988681 TAS G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 IEA serotonin receptor signaling pathway GO:0007210 IEA cAMP-mediated signaling GO:0019933 IEA hippocampus development GO:0021766 IEA response to estradiol GO:0032355 IEA",G-protein coupled serotonin receptor activity IDA 7988681 GO:0004993,Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Serotonergic synapse - Homo sapiens (human) hsa04726,CHEMBL CHEMBL260994,P34969,Serotonin 7 (5-HT7) receptor,1.0,ORTHOGONAL,NO,Clc1ccc(cc1)N2CCN(CCCCC3C(=O)Nc4ccccc34)CC2,7,14,"InChI=1S/C22H26ClN3O/c23-17-8-10-18(11-9-17)26-15-13-25(14-16-26)12-4-3-6-20-19-5-1-2-7-21(19)24-22(20)27/h1-2,5,7-11,20H,3-4,6,12-16H2,(H,24,27)",JAOXKCOCADFHNG-UHFFFAOYSA-N,"c(""Serotonin 7 (5-HT7) receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 2c (5-HT2c) receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Alpha-1a adrenergic receptor"", ""Dopamine D1 receptor"", ""Dopamine D2 receptor"", ""Unchecked"")",3363,5HT7R,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375280 Amine ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-390666 Serotonin receptors R-HSA-418555 G alpha (s) signalling events R-HSA-500792 GPCR ligand binding,TAS GO:0005886 plasma membrane TAS 8226867 integral component of plasma membrane GO:0005887,"smooth muscle contraction GO:0006939 IEA G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 8226867 GO:0007187 TAS serotonin receptor signaling pathway GO:0007210 IEA chemical synaptic transmission GO:0007268 IEA circadian rhythm GO:0007623 IEA blood circulation 8226867 GO:0008015 TAS vasoconstriction GO:0042310 IEA",GO:0004993 G-protein coupled serotonin receptor activity IEA,hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04726 Serotonergic synapse - Homo sapiens (human),CHEMBL CHEMBL12264,P34969,Serotonin 7 (5-HT7) receptor,1.0,PRIMARY,NO,C[C@H](CCN1CCC(C)CC1)N(C)S(=O)(=O)c2cccc(C)c2,13,21,"InChI=1S/C18H30N2O2S/c1-15-8-11-20(12-9-15)13-10-17(3)19(4)23(21,22)18-7-5-6-16(2)14-18/h5-7,14-15,17H,8-13H2,1-4H3/t17-/m1/s1",AGVNHDNTFYHZNL-QGZVFWFLSA-N,"c(""Serotonin 7 (5-HT7) receptor"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Serotonin 1d (5-HT1d) receptor"", ""Serotonin 1e (5-HT1e) receptor"", ""Serotonin 1f (5-HT1f) receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Serotonin 2b (5-HT2b) receptor"", ""Serotonin 2c (5-HT2c) receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Alpha-1b adrenergic receptor"", ""Dopamine D2 receptor"", ""Dopamine D3 receptor"")",3363,5HT7R,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375280 Amine ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-390666 Serotonin receptors R-HSA-418555 G alpha (s) signalling events R-HSA-500792 GPCR ligand binding,TAS GO:0005886 plasma membrane TAS 8226867 integral component of plasma membrane GO:0005887,"smooth muscle contraction GO:0006939 IEA G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 8226867 GO:0007187 TAS serotonin receptor signaling pathway GO:0007210 IEA chemical synaptic transmission GO:0007268 IEA circadian rhythm GO:0007623 IEA blood circulation 8226867 GO:0008015 TAS vasoconstriction GO:0042310 IEA",GO:0004993 G-protein coupled serotonin receptor activity IEA,hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04726 Serotonergic synapse - Homo sapiens (human),CHEMBL CHEMBL2391147,Q99720,Sigma opioid receptor,1.0,PRIMARY,NO,C[C@H]1[C@H](CC(=O)N1CC(=O)N)c2ccccc2,16,23,"InChI=1S/C13H16N2O2/c1-9-11(10-5-3-2-4-6-10)7-13(17)15(9)8-12(14)16/h2-6,9,11H,7-8H2,1H3,(H2,14,16)/t9-,11-/m0/s1",ZTGRWYMPQCQTHD-ONGXEEELSA-N,"c(""Serotonin transporter"", ""Dopamine transporter"", ""Unchecked"", ""Vasopressin V1a receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Nociceptin receptor"", ""Melanocortin receptor 4"", ""Interleukin-8 receptor B"", ""Endothelin receptor ET-B"", ""Dopamine D3 receptor"", ""Dopamine D2 receptor"", ""Cholecystokinin B receptor"", ""Cholecystokinin A receptor"", ""Calcitonin gene-related peptide type 1 receptor"", ""Bradykinin B2 receptor"", ""Adenosine A1 receptor"", ""Sigma opioid receptor"")",10280,SGMR1,,9341151 IDA GO:0005635 nuclear envelope IEA GO:0005637 nuclear inner membrane IEA GO:0005640 nuclear outer membrane IEA GO:0005789 endoplasmic reticulum membrane IEA GO:0005811 lipid particle 8954936 TAS GO:0005887 integral component of plasma membrane 9453537 TAS GO:0016021 integral component of membrane IEA GO:0030054 cell junction IEA GO:0030426 growth cone IEA GO:0045211 postsynaptic membrane,GO:0006869 lipid transport IEA GO:0007399 nervous system development IEA GO:0038003 opioid receptor signaling pathway IEA 21842496 GO:0043523 regulation of neuron apoptotic process IMP,opioid receptor activity GO:0004985 IEA drug binding GO:0008144 TAS 8954936,,CHEMBL CHEMBL2059863,Q99835,Smoothened homolog,1.0,ORTHOGONAL,NO,Cc1ccc(cc1NC(=O)c2ccc(OCc3ccccn3)cc2)c4ncc([nH]4)C(F)(F)F,2,3,"InChI=1S/C24H19F3N4O2/c1-15-5-6-17(22-29-13-21(31-22)24(25,26)27)12-20(15)30-23(32)16-7-9-19(10-8-16)33-14-18-4-2-3-11-28-18/h2-13H,14H2,1H3,(H,29,31)(H,30,32)",BQZARCIQCQXWNH-UHFFFAOYSA-N,"c(""Smoothened homolog"", ""MAP kinase p38 alpha"")",6608,SMO,"R-HSA-162582 Signal Transduction R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-372790 Signaling by GPCR R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-500792 GPCR ligand binding R-HSA-5358351 Signaling by Hedgehog R-HSA-5617833 Assembly of the primary cilium R-HSA-5620920 Cargo trafficking to the periciliary membrane R-HSA-5620922 BBSome-mediated cargo-targeting to cilium R-HSA-5632684 Hedgehog ,on, state R-HSA-5635838 Activation of SMO",Golgi apparatus GO:0005794 11278759 IDA colocalizes_with plasma membrane GO:0005886 19304771 IDA caveola GO:0005901 11278759 IDA colocalizes_with integral component of membrane GO:0016021 IBA endocytic vesicle membrane GO:0030666 TAS intracellular membrane-bounded organelle GO:0043231 11278759 IDA ciliary membrane GO:0060170 TAS extracellular exosome GO:0070062 19056867 23533145 IDA primary cilium GO:0072372 21931618 TAS ciliary tip GO:0097542 TAS,negative regulation of transcription from RNA polymerase II promoter IEA GO:0000122 vasculogenesis IEA GO:0001570 osteoblast differentiation IEA GO:0001649 in utero embryonic development IEA GO:0001701 cell fate specification IEA GO:0001708 neural crest cell migration IEA GO:0001755 heart looping ISS GO:0001947 positive regulation of neuroblast proliferation IEA GO:0002052 positive regulation of mesenchymal cell proliferation IEA GO:0002053 determination of left/right asymmetry in lateral mesoderm ISS GO:0003140 type B pancreatic cell development IEA GO:0003323 G-protein coupled receptor signaling pathway IEA GO:0007186 smoothened signaling pathway IEP 17850284 GO:0007224 smoothened signaling pathway IMP 9422511 19304771 21177415 GO:0007224 positive regulation of hh target transcription factor activity ISS GO:0007228 ventral midline determination ISS GO:0007371 midgut development ISS GO:0007494 anterior/posterior pattern specification IEA GO:0009952 positive regulation of gene expression ISS GO:0010628 negative regulation of gene expression ISS GO:0010629 dentate gyrus development IEA GO:0021542 cerebellar cortex morphogenesis IEA GO:0021696 thalamus development IEA GO:0021794 dorsal/ventral neural tube patterning IEA GO:0021904 smoothened signaling pathway involved in ventral spinal cord patterning IEA GO:0021910 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IEA GO:0021938 central nervous system neuron differentiation IEA GO:0021953 cerebral cortex development IEA GO:0021987 negative regulation of epithelial cell differentiation IEA GO:0030857 hair follicle morphogenesis IEA GO:0031069 protein localization to nucleus IEA GO:0034504 multicellular organism growth IEA GO:0035264 NOT non-canonical Wnt signaling pathway IBA GO:0035567 positive regulation of multicellular organism growth IEA GO:0040018 positive regulation of protein import into nucleus IEA GO:0042307 odontogenesis of dentin-containing tooth IEA GO:0042475 negative regulation of apoptotic process IEA GO:0043066 negative regulation of DNA binding ISS GO:0043392 positive regulation of smoothened signaling pathway IEA GO:0045880 positive regulation of transcription from RNA polymerase II promoter IEA GO:0045944 positive regulation of organ growth IEA GO:0046622 astrocyte activation IEA GO:0048143 skeletal muscle fiber development IEA GO:0048741 forebrain morphogenesis ISS GO:0048853 homeostasis of number of cells within a tissue IEA GO:0048873 positive regulation of epithelial cell proliferation IEA GO:0050679 protein stabilization IEA GO:0050821 myoblast migration IEA GO:0051451 negative regulation of hair follicle development IEA GO:0051799 NOT canonical Wnt signaling pathway IBA GO:0060070 detection of cell density by contact stimulus involved in contact inhibition IMP 9422511 GO:0060248 atrial septum morphogenesis IEA GO:0060413 mammary gland epithelial cell differentiation IEA GO:0060644 epithelial-mesenchymal cell signaling IEA GO:0060684 somite development ISS GO:0061053 pancreas morphogenesis IEA GO:0061113 left/right axis specification IEA GO:0070986 cellular response to cholesterol ISS GO:0071397 renal system development IEP 17850284 GO:0072001 mesenchymal to epithelial transition involved in metanephric renal vesicle formation ISS GO:0072285 positive regulation of branching involved in ureteric bud morphogenesis ISS GO:0090190 regulation of stem cell population maintenance IEA GO:2000036 regulation of heart morphogenesis ISS GO:2000826,IBA GO:0004930 G-protein coupled receptor activity IPI 9811851 patched binding GO:0005113 IPI 19592253 protein binding GO:0005515 IDA 19304771 21177415 drug binding GO:0008144 IBA GO:0017147 Wnt-protein binding IBA NOT GO:0042813 Wnt-activated receptor activity,Hedgehog signaling pathway - Homo sapiens (human) hsa04340 Pathways in cancer - Homo sapiens (human) hsa05200 Proteoglycans in cancer - Homo sapiens (human) hsa05205 Basal cell carcinoma - Homo sapiens (human) hsa05217,CHEMBL CHEMBL254129,Q99835,Smoothened homolog,1.0,PRIMARY,NO,C[C@@H]1CN[C@@H]2[C@@H](C1)O[C@]3(CC[C@H]4[C@@H]5CC=C6C[C@@H](O)CC[C@]6(C)[C@H]5CC4=C3C)[C@@H]2C,3,102,"InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1",QASFUMOKHFSJGL-LAFRSMQTSA-N,"c(""A549"", ""Unchecked"", ""Smoothened homolog"", ""Runt-related transcription factor 1/Core-binding factor subunit beta"", ""Vitamin D receptor"", ""Sonic hedgehog protein"", ""DJM-1"", ""COLO-829"", ""DOHH-2"", ""ALL-PO"", ""ATN-1"", ""BB30-HNC"", ""CTV-1"", ""697"", ""BC1 cell line"", ""8-MG-BA"", ""BE-13"", ""CESS"", ""D-247MG"", ""D-392MG"", ""D-502MG"", ""A388"", ""D-542MG"", ""DEL"", ""GI-1"", ""IST-SL2"", ""RPMI 8402"", ""LOX IMVI"", ""LP-1"", ""OS-RC-2"", ""RS4-11"", ""MHH-PREB-1"", ""OVCAR-4"", ""LS-513"", ""SK-NEP-1"", ""EVSA-T"", ""ML-2"", ""L-363"", ""HCC1599"", ""KARPAS-45"", ""LAMA-84"", ""KE-37"", ""MRK-nu-1"", ""EOL1"", ""MS-1"", ""NOS-1"", ""SR"", ""MV4-11"", ""NTERA-2-cl-D1"", ""no-10"", ""no-11"", ""OCI-AML2"", ""GCIY"", ""LC4-1"", ""NALM-6"", ""IST-MES1"", ""Nuclear factor erythroid 2-related factor 2"", ""DNA-(apurinic or apyrimidinic site) lyase"")",6608,SMO,"R-HSA-162582 Signal Transduction R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-372790 Signaling by GPCR R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-500792 GPCR ligand binding R-HSA-5358351 Signaling by Hedgehog R-HSA-5617833 Assembly of the primary cilium R-HSA-5620920 Cargo trafficking to the periciliary membrane R-HSA-5620922 BBSome-mediated cargo-targeting to cilium R-HSA-5632684 Hedgehog ,on, state R-HSA-5635838 Activation of SMO",Golgi apparatus GO:0005794 11278759 IDA colocalizes_with plasma membrane GO:0005886 19304771 IDA caveola GO:0005901 11278759 IDA colocalizes_with integral component of membrane GO:0016021 IBA endocytic vesicle membrane GO:0030666 TAS intracellular membrane-bounded organelle GO:0043231 11278759 IDA ciliary membrane GO:0060170 TAS extracellular exosome GO:0070062 19056867 23533145 IDA primary cilium GO:0072372 21931618 TAS ciliary tip GO:0097542 TAS,negative regulation of transcription from RNA polymerase II promoter IEA GO:0000122 vasculogenesis IEA GO:0001570 osteoblast differentiation IEA GO:0001649 in utero embryonic development IEA GO:0001701 cell fate specification IEA GO:0001708 neural crest cell migration IEA GO:0001755 heart looping ISS GO:0001947 positive regulation of neuroblast proliferation IEA GO:0002052 positive regulation of mesenchymal cell proliferation IEA GO:0002053 determination of left/right asymmetry in lateral mesoderm ISS GO:0003140 type B pancreatic cell development IEA GO:0003323 G-protein coupled receptor signaling pathway IEA GO:0007186 smoothened signaling pathway IEP 17850284 GO:0007224 smoothened signaling pathway IMP 9422511 19304771 21177415 GO:0007224 positive regulation of hh target transcription factor activity ISS GO:0007228 ventral midline determination ISS GO:0007371 midgut development ISS GO:0007494 anterior/posterior pattern specification IEA GO:0009952 positive regulation of gene expression ISS GO:0010628 negative regulation of gene expression ISS GO:0010629 dentate gyrus development IEA GO:0021542 cerebellar cortex morphogenesis IEA GO:0021696 thalamus development IEA GO:0021794 dorsal/ventral neural tube patterning IEA GO:0021904 smoothened signaling pathway involved in ventral spinal cord patterning IEA GO:0021910 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IEA GO:0021938 central nervous system neuron differentiation IEA GO:0021953 cerebral cortex development IEA GO:0021987 negative regulation of epithelial cell differentiation IEA GO:0030857 hair follicle morphogenesis IEA GO:0031069 protein localization to nucleus IEA GO:0034504 multicellular organism growth IEA GO:0035264 NOT non-canonical Wnt signaling pathway IBA GO:0035567 positive regulation of multicellular organism growth IEA GO:0040018 positive regulation of protein import into nucleus IEA GO:0042307 odontogenesis of dentin-containing tooth IEA GO:0042475 negative regulation of apoptotic process IEA GO:0043066 negative regulation of DNA binding ISS GO:0043392 positive regulation of smoothened signaling pathway IEA GO:0045880 positive regulation of transcription from RNA polymerase II promoter IEA GO:0045944 positive regulation of organ growth IEA GO:0046622 astrocyte activation IEA GO:0048143 skeletal muscle fiber development IEA GO:0048741 forebrain morphogenesis ISS GO:0048853 homeostasis of number of cells within a tissue IEA GO:0048873 positive regulation of epithelial cell proliferation IEA GO:0050679 protein stabilization IEA GO:0050821 myoblast migration IEA GO:0051451 negative regulation of hair follicle development IEA GO:0051799 NOT canonical Wnt signaling pathway IBA GO:0060070 detection of cell density by contact stimulus involved in contact inhibition IMP 9422511 GO:0060248 atrial septum morphogenesis IEA GO:0060413 mammary gland epithelial cell differentiation IEA GO:0060644 epithelial-mesenchymal cell signaling IEA GO:0060684 somite development ISS GO:0061053 pancreas morphogenesis IEA GO:0061113 left/right axis specification IEA GO:0070986 cellular response to cholesterol ISS GO:0071397 renal system development IEP 17850284 GO:0072001 mesenchymal to epithelial transition involved in metanephric renal vesicle formation ISS GO:0072285 positive regulation of branching involved in ureteric bud morphogenesis ISS GO:0090190 regulation of stem cell population maintenance IEA GO:2000036 regulation of heart morphogenesis ISS GO:2000826,IBA GO:0004930 G-protein coupled receptor activity IPI 9811851 patched binding GO:0005113 IPI 19592253 protein binding GO:0005515 IDA 19304771 21177415 drug binding GO:0008144 IBA GO:0017147 Wnt-protein binding IBA NOT GO:0042813 Wnt-activated receptor activity,Hedgehog signaling pathway - Homo sapiens (human) hsa04340 Pathways in cancer - Homo sapiens (human) hsa05200 Proteoglycans in cancer - Homo sapiens (human) hsa05205 Basal cell carcinoma - Homo sapiens (human) hsa05217,CHEMBL CHEMBL3319620,Q9Y4D2,Sn1-specific diacylglycerol lipase alpha,1.0,PRIMARY,NO,CC1(C)CCc2cc(ccc2O1)S(=O)(=O)N(CC(=O)O)Cc3ccc(Oc4ccccc4)cc3,2,3,"InChI=1S/C26H27NO6S/c1-26(2)15-14-20-16-23(12-13-24(20)33-26)34(30,31)27(18-25(28)29)17-19-8-10-22(11-9-19)32-21-6-4-3-5-7-21/h3-13,16H,14-15,17-18H2,1-2H3,(H,28,29)",FOEGBOXMDBPYEV-UHFFFAOYSA-N,"c(""Sn1-specific diacylglycerol lipase alpha"", ""Monoacylglycerol lipase ABHD6"")",747,DGLA,"Hemostasis R-HSA-109582 Effects of PIP2 hydrolysis R-HSA-114508 Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 GPCR downstream signaling R-HSA-388396 G alpha (q) signalling events R-HSA-416476 Arachidonate production from DAG R-HSA-426048 Platelet activation, signaling and aggregation R-HSA-76002 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907",plasma membrane GO:0005886 TAS integral component of membrane GO:0016021 IEA varicosity GO:0043196 IEA,GO:0007405 neuroblast proliferation IEA GO:0019369 arachidonic acid metabolic process 14610053 IDA GO:0042136 neurotransmitter biosynthetic process 14610053 IDA GO:0046340 diacylglycerol catabolic process 14610053 IDA GO:0071926 endocannabinoid signaling pathway IEA,IEA GO:0046872 metal ion binding TAS GO:0047372 acylglycerol lipase activity,hsa04723 Retrograde endocannabinoid signaling - Homo sapiens (human),CHEMBL CHEMBL250699,Q9Y5Y9,Sodium channel protein type X alpha subunit,1.0,PRIMARY,NO,COc1cc(NC(=O)c2oc(cc2)c3ccc(Cl)cc3)cc(OC)c1,49,107,"InChI=1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)",VHKBTPQDHDSBSP-UHFFFAOYSA-N,"c(""Sodium channel protein type IX alpha subunit"", ""Unchecked"", ""Sodium channel protein type X alpha subunit"", ""Sodium channel protein type II alpha subunit"", ""Sodium channel protein type III alpha subunit"", ""Sodium channel protein type V alpha subunit"", ""Translocator protein"", ""Cholecystokinin A receptor"", ""Dopamine D1 receptor"", ""Serotonin 2a (5-HT2a) receptor"", ""Adenosine A1 receptor"", ""Adenosine A2a receptor"", ""Adenosine A3 receptor"", ""Alpha-2a adrenergic receptor"", ""Alpha-1b adrenergic receptor"", ""Alpha-2b adrenergic receptor"", ""Endothelin receptor ET-A"", ""Cannabinoid CB1 receptor"", ""Cannabinoid CB2 receptor"", ""Dopamine D2 receptor"", ""Dopamine D3 receptor"", ""Dopamine D5 receptor"", ""Interleukin-8 receptor B"", ""C-C chemokine receptor type 1"", ""Histamine H1 receptor"", ""Histamine H2 receptor"", ""Muscarinic acetylcholine receptor M1"", ""Muscarinic acetylcholine receptor M2"", ""Muscarinic acetylcholine receptor M3"", ""Muscarinic acetylcholine receptor M4"", ""Muscarinic acetylcholine receptor M5"", ""Delta opioid receptor"", ""Kappa opioid receptor"", ""Mu opioid receptor"", ""Nociceptin receptor"", ""P2X purinoceptor 2"", ""Purinergic receptor P2Y2"", ""Serotonin 1a (5-HT1a) receptor"", ""Serotonin 1b (5-HT1b) receptor"", ""Serotonin 2c (5-HT2c) receptor"", ""Serotonin 3a (5-HT3a) receptor"", ""Serotonin 5a (5-HT5a) receptor"", ""Serotonin 6 (5-HT6) receptor"", ""Serotonin 7 (5-HT7) receptor"", ""Sigma opioid receptor"", ""Vanilloid receptor"", ""P2X purinoceptor 3"", ""Voltage-gated N-type calcium channel alpha-1B subunit"", ""Voltage-gated potassium channel subunit Kv7.2"", ""Voltage-gated potassium channel subunit Kv7.3"")",6336,SCNAA,Developmental Biology R-HSA-1266738 L1CAM interactions R-HSA-373760 Axon guidance R-HSA-422475 Interaction between L1 and Ankyrins R-HSA-445095,9839820 GO:0001518 voltage-gated sodium channel complex IDA 19056867 GO:0070062 extracellular exosome IDA GO:0071439 clathrin complex IEA,regulation of heart rate GO:0002027 IMP 20062061 21041692 sensory perception GO:0007600 TAS 9839820 neuronal action potential GO:0019228 IBA sensory perception of pain GO:0019233 IEA regulation of ion transmembrane transport GO:0034765 IDA 9839820 sodium ion transmembrane transport GO:0035725 IDA 9839820 odontogenesis of dentin-containing tooth GO:0042475 IEA regulation of cardiac muscle contraction GO:0055117 IMP 20062061 regulation of postsynaptic membrane potential GO:0060078 IEA regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 IMP 20062061 21041692 membrane depolarization during action potential GO:0086010 IBA AV node cell action potential GO:0086016 IMP 24998131 bundle of His cell action potential GO:0086043 IMP 24998131,voltage-gated sodium channel activity GO:0005248 9839820 IDA ion channel binding GO:0044325 24998131 IPI,,CHEMBL CHEMBL3318586,Q99884,Sodium-dependent proline transporter,1.0,PRIMARY,NO,Clc1cccc(c1)c2ccc(cc2)C(=O)N3C4CCC3CN(C4)c5ncccn5,2,3,"InChI=1S/C23H21ClN4O/c24-19-4-1-3-18(13-19)16-5-7-17(8-6-16)22(29)28-20-9-10-21(28)15-27(14-20)23-25-11-2-12-26-23/h1-8,11-13,20-21H,9-10,14-15H2",FNHAFYQTHUKPIU-UHFFFAOYSA-N,"c(""Sodium-dependent proline transporter"", ""Dopamine transporter"", ""Unchecked"")",6534,SC6A7,"R-HSA-1430728 Metabolism R-HSA-382551 Transmembrane transport of small molecules R-HSA-425366 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds R-HSA-425407 SLC-mediated transmembrane transport R-HSA-425428 Amine compound SLC transporters R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters R-HSA-71288 Creatine metabolism R-HSA-71291 Metabolism of amino acids and derivatives",plasma membrane TAS GO:0005886 integral component of plasma membrane TAS 7651355 GO:0005887 membrane TAS 7651355 GO:0016020,TAS 7651355 transport GO:0006810 IEA GO:0006836 neurotransmitter transport TAS 7651355 proline transport GO:0015824 IEA GO:0035524 proline transmembrane transport,proline:sodium symporter activity GO:0005298 TAS neurotransmitter:sodium symporter activity GO:0005328 IEA L-proline transmembrane transporter activity GO:0015193 IBA,,CHEMBL CHEMBL2159094,P13866,Sodium/glucose cotransporter 1,1.0,ORTHOGONAL,NO,OC[C@H]1O[C@@H](Oc2n[nH]c(c2Cc3ccccc3OCc4ccccc4)C(F)(F)F)[C@H](O)[C@@H](O)[C@@H]1O,2,4,"InChI=1S/C24H25F3N2O7/c25-24(26,27)21-15(10-14-8-4-5-9-16(14)34-12-13-6-2-1-3-7-13)22(29-28-21)36-23-20(33)19(32)18(31)17(11-30)35-23/h1-9,17-20,23,30-33H,10-12H2,(H,28,29)/t17-,18-,19+,20-,23+/m1/s1",VRWBPJPUNCXWHA-MZSWFSNMSA-N,"c(""Unchecked"", ""Sodium/glucose cotransporter 2"", ""Sodium/glucose cotransporter 1"")",6523,SC5A1,"Metabolism R-HSA-1430728 Hexose transport R-HSA-189200 Transmembrane transport of small molecules R-HSA-382551 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds R-HSA-425366 SLC-mediated transmembrane transport R-HSA-425407 Na+-dependent glucose transporters R-HSA-428808 Inositol transporters R-HSA-429593 Metabolism of carbohydrates R-HSA-71387",GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 8563765 TAS GO:0005911 cell-cell junction IEA GO:0016324 apical plasma membrane IEA GO:0031526 brush border membrane IEA GO:0070062 extracellular exosome 19056867 23376485 IDA,IBA GO:0001951 intestinal D-glucose absorption IEA GO:0006814 sodium ion transport TAS GO:0008645 hexose transport 8563765 IMP GO:0015758 glucose transport IEA GO:1904659 glucose transmembrane transport,8563765 GO:0005412 glucose:sodium symporter activity IDA GO:0005412 glucose:sodium symporter activity TAS 18455122 GO:0005515 protein binding IPI,hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human) hsa04976 Bile secretion - Homo sapiens (human) hsa04978 Mineral absorption - Homo sapiens (human),CHEMBL CHEMBL2323695,P13866,Sodium/glucose cotransporter 1,1.0,PRIMARY,NO,CC(C)c1[nH]nc(O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)c1Cc3ccc(CCCC(=O)NC(C)(C)C(=O)N4CCNCC4)cc3C,2,4,"InChI=1S/C32H49N5O8/c1-18(2)25-22(29(36-35-25)45-30-28(42)27(41)26(40)23(17-38)44-30)16-21-10-9-20(15-19(21)3)7-6-8-24(39)34-32(4,5)31(43)37-13-11-33-12-14-37/h9-10,15,18,23,26-28,30,33,38,40-42H,6-8,11-14,16-17H2,1-5H3,(H,34,39)(H,35,36)/t23-,26-,27+,28-,30+/m1/s1",HZIRWWOSGYBPSU-RHBSMATHSA-N,"c(""Unchecked"", ""Sodium/glucose cotransporter 2"", ""Sodium/glucose cotransporter 1"")",6523,SC5A1,"Metabolism R-HSA-1430728 Hexose transport R-HSA-189200 Transmembrane transport of small molecules R-HSA-382551 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds R-HSA-425366 SLC-mediated transmembrane transport R-HSA-425407 Na+-dependent glucose transporters R-HSA-428808 Inositol transporters R-HSA-429593 Metabolism of carbohydrates R-HSA-71387",GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 8563765 TAS GO:0005911 cell-cell junction IEA GO:0016324 apical plasma membrane IEA GO:0031526 brush border membrane IEA GO:0070062 extracellular exosome 19056867 23376485 IDA,IBA GO:0001951 intestinal D-glucose absorption IEA GO:0006814 sodium ion transport TAS GO:0008645 hexose transport 8563765 IMP GO:0015758 glucose transport IEA GO:1904659 glucose transmembrane transport,8563765 GO:0005412 glucose:sodium symporter activity IDA GO:0005412 glucose:sodium symporter activity TAS 18455122 GO:0005515 protein binding IPI,hsa04973 Carbohydrate digestion and absorption - Homo sapiens (human) hsa04976 Bile secretion - Homo sapiens (human) hsa04978 Mineral absorption - Homo sapiens (human),CHEMBL CHEMBL496138,P31639,Sodium/glucose cotransporter 2,1.0,ORTHOGONAL,NO,CCc1ccc(Cc2cc(ccc2Cl)[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)cc1,2,8,"InChI=1S/C21H25ClO5/c1-2-12-3-5-13(6-4-12)9-15-10-14(7-8-16(15)22)21-20(26)19(25)18(24)17(11-23)27-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1",QPNWHIMAZBIEMR-ADAARDCZSA-N,"c(""Sodium/glucose cotransporter 2"", ""Sodium/glucose cotransporter 1"", ""Unchecked"")",6524,SC5A2,"R-HSA-1430728 Metabolism R-HSA-189200 Hexose transport R-HSA-382551 Transmembrane transport of small molecules R-HSA-425366 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds R-HSA-425407 SLC-mediated transmembrane transport R-HSA-428808 Na+-dependent glucose transporters R-HSA-429593 Inositol transporters R-HSA-71387 Metabolism of carbohydrates",plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 IBA integral component of membrane GO:0016021 TAS 8244402 brush border membrane GO:0031526 IEA extracellular exosome GO:0070062 IDA 19056867 23376485,carbohydrate metabolic process GO:0005975 8244402 TAS transport GO:0006810 8244402 TAS sodium ion transport GO:0006814 IEA glucose transmembrane transport GO:1904659 IEA,low-affinity glucose:sodium symporter activity TAS 8244402 GO:0005362 glucose:sodium symporter activity TAS GO:0005412,,CHEMBL CHEMBL1762505,P31639,Sodium/glucose cotransporter 2,1.0,PRIMARY,NO,FC(F)(F)CCn1c(CCc2ccc(Cl)cc2)nnc1CN3C(=O)COc4c(Cl)cc(Cl)cc34,3,9,"InChI=1S/C22H18Cl3F3N4O2/c23-14-4-1-13(2-5-14)3-6-18-29-30-19(31(18)8-7-22(26,27)28)11-32-17-10-15(24)9-16(25)21(17)34-12-20(32)33/h1-2,4-5,9-10H,3,6-8,11-12H2",SQEQQCICFNBUOP-UHFFFAOYSA-N,"c(""Unchecked"", ""Sodium/glucose cotransporter 2"", ""Sodium/glucose cotransporter 1"", ""Sodium/myo-inositol cotransporter 2"")",6524,SC5A2,"R-HSA-1430728 Metabolism R-HSA-189200 Hexose transport R-HSA-382551 Transmembrane transport of small molecules R-HSA-425366 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds R-HSA-425407 SLC-mediated transmembrane transport R-HSA-428808 Na+-dependent glucose transporters R-HSA-429593 Inositol transporters R-HSA-71387 Metabolism of carbohydrates",plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 IBA integral component of membrane GO:0016021 TAS 8244402 brush border membrane GO:0031526 IEA extracellular exosome GO:0070062 IDA 19056867 23376485,carbohydrate metabolic process GO:0005975 8244402 TAS transport GO:0006810 8244402 TAS sodium ion transport GO:0006814 IEA glucose transmembrane transport GO:1904659 IEA,low-affinity glucose:sodium symporter activity TAS 8244402 GO:0005362 glucose:sodium symporter activity TAS GO:0005412,,CHEMBL CHEMBL71723,P30872,Somatostatin receptor 1,1.0,ORTHOGONAL,NO,NC[C@@H]1CCC[C@H](CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)N4CCC5(CC4)C=Cc6ccccc56)C1,5,5,"InChI=1S/C33H41N5O2/c34-20-23-6-5-7-24(18-23)21-36-31(39)30(19-26-22-35-29-11-4-2-9-27(26)29)37-32(40)38-16-14-33(15-17-38)13-12-25-8-1-3-10-28(25)33/h1-4,8-13,22-24,30,35H,5-7,14-21,34H2,(H,36,39)(H,37,40)/t23-,24+,30+/m1/s1",DAMXHAMKVXERLM-QEGDFHJFSA-N,"c(""Somatostatin receptor 2"", ""Somatostatin receptor 1"", ""Somatostatin receptor 3"", ""Somatostatin receptor 4"", ""Somatostatin receptor 5"")",6751,SSR1,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,IEA GO:0005737 cytoplasm TAS GO:0005886 plasma membrane TAS 1346068 integral component of plasma membrane GO:0005887 IBA GO:0043005 neuron projection,"cell surface receptor signaling pathway 1346068 GO:0007166 TAS G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 8405411 GO:0007187 TAS glutamate receptor signaling pathway GO:0007215 IEA neuropeptide signaling pathway GO:0007218 IEA cell-cell signaling 1346068 GO:0007267 TAS chemical synaptic transmission GO:0007268 IBA spermatogenesis GO:0007283 IEA response to nutrient 1346068 GO:0007584 TAS digestion 1346068 GO:0007586 TAS negative regulation of cell proliferation 9886848 GO:0008285 TAS cerebellum development GO:0021549 IEA forebrain development GO:0030900 IEA somatostatin signaling pathway GO:0038170 IEA response to starvation GO:0042594 IEA cellular response to estradiol stimulus GO:0071392 IBA",GO:0004994 somatostatin receptor activity 1346068 IDA GO:0042923 neuropeptide binding IBA,hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL556949,P30872,Somatostatin receptor 1,1.0,PRIMARY,NO,CC(C)NCc1ccc(C[C@@H]2NC(=O)[C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@H](Cc6ccccc6)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc7ccccc7)NC(=O)[C@@H](NC2=O)[C@@H](C)O)[C@@H](C)O)C(=O)O)NC(=O)[C@@H](N)Cc8ccc(O)cc8)cc1,5,6,"InChI=1S/C83H105N15O17S2/c1-47(2)86-42-55-29-27-54(28-30-55)40-64-77(108)97-70(48(3)100)81(112)93-65(39-52-22-12-7-13-23-52)78(109)98-71(49(4)101)82(113)94-67(44-99)79(110)96-69(83(114)115)46-117-116-45-68(95-72(103)59(85)36-53-31-33-57(102)34-32-53)80(111)88-61(26-16-17-35-84)73(104)89-62(37-50-18-8-5-9-19-50)74(105)90-63(38-51-20-10-6-11-21-51)75(106)92-66(76(107)91-64)41-56-43-87-60-25-15-14-24-58(56)60/h5-15,18-25,27-34,43,47-49,59,61-71,86-87,99-102H,16-17,26,35-42,44-46,84-85H2,1-4H3,(H,88,111)(H,89,104)(H,90,105)(H,91,107)(H,92,106)(H,93,112)(H,94,113)(H,95,103)(H,96,110)(H,97,108)(H,98,109)(H,114,115)/t48-,49-,59+,61+,62+,63+,64+,65+,66-,67+,68+,69+,70+,71+/m1/s1",UKGIKHPFMXOGRF-RABWJYHCSA-N,"c(""Somatostatin receptor 1"", ""Somatostatin receptor 2"", ""Somatostatin receptor 3"", ""Somatostatin receptor 4"", ""Somatostatin receptor 5"")",6751,SSR1,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding,IEA GO:0005737 cytoplasm TAS GO:0005886 plasma membrane TAS 1346068 integral component of plasma membrane GO:0005887 IBA GO:0043005 neuron projection,"cell surface receptor signaling pathway 1346068 GO:0007166 TAS G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 8405411 GO:0007187 TAS glutamate receptor signaling pathway GO:0007215 IEA neuropeptide signaling pathway GO:0007218 IEA cell-cell signaling 1346068 GO:0007267 TAS chemical synaptic transmission GO:0007268 IBA spermatogenesis GO:0007283 IEA response to nutrient 1346068 GO:0007584 TAS digestion 1346068 GO:0007586 TAS negative regulation of cell proliferation 9886848 GO:0008285 TAS cerebellum development GO:0021549 IEA forebrain development GO:0030900 IEA somatostatin signaling pathway GO:0038170 IEA response to starvation GO:0042594 IEA cellular response to estradiol stimulus GO:0071392 IBA",GO:0004994 somatostatin receptor activity 1346068 IDA GO:0042923 neuropeptide binding IBA,hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL305279,P30874,Somatostatin receptor 2,1.0,ORTHOGONAL,NO,NCC1CCCC(CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)N4CCC5(CC4)C=Cc6ccccc56)C1,5,5,"InChI=1S/C33H41N5O2/c34-20-23-6-5-7-24(18-23)21-36-31(39)30(19-26-22-35-29-11-4-2-9-27(26)29)37-32(40)38-16-14-33(15-17-38)13-12-25-8-1-3-10-28(25)33/h1-4,8-13,22-24,30,35H,5-7,14-21,34H2,(H,36,39)(H,37,40)/t23?,24?,30-/m0/s1",DAMXHAMKVXERLM-YFIBMDDPSA-N,"c(""Somatostatin receptor 2"", ""Somatostatin receptor 1"", ""Somatostatin receptor 3"", ""Somatostatin receptor 4"", ""Somatostatin receptor 5"")",6752,SSR2,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,IEA GO:0005737 cytoplasm TAS GO:0005886 plasma membrane 7914078 TAS GO:0005887 integral component of plasma membrane IBA GO:0043005 neuron projection,"GO:0006937 regulation of muscle contraction IEA 7914078 GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA GO:0007218 neuropeptide signaling pathway IEA 1346068 GO:0007267 cell-cell signaling TAS GO:0007268 chemical synaptic transmission IBA GO:0007283 spermatogenesis IEA 1346068 GO:0007584 response to nutrient TAS 1346068 GO:0007586 digestion TAS 9892014 GO:0008285 negative regulation of cell proliferation TAS GO:0021549 cerebellum development IEA GO:0030432 peristalsis IEA GO:0030900 forebrain development IEA GO:0038170 somatostatin signaling pathway IEA GO:0042594 response to starvation IEA GO:0071385 cellular response to glucocorticoid stimulus IBA GO:0071392 cellular response to estradiol stimulus IBA",somatostatin receptor activity GO:0004994 IEA protein binding GO:0005515 IPI 10551867 16917505 22651821 PDZ domain binding GO:0030165 IPI 10551867 neuropeptide binding GO:0042923 IBA,hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04971 Gastric acid secretion - Homo sapiens (human),CHEMBL CHEMBL3144285,P30874,Somatostatin receptor 2,1.0,PRIMARY,NO,C[C@@H](O)[C@H](NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC[C@]3(O)OC[C@H](O)[C@@H](O[C@@H]4O[C@@H](CO)[C@@H](O)[C@H](O)[C@@H]4O)[C@@H]3O)C(=O)N[C@@H](Cc5ccc(O)c(I)c5)C(=O)N[C@H](Cc6c[nH]c7ccccc67)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1)C(=O)O,5,5,"InChI=1S/C61H83IN10O22S2/c1-28(74)45-58(88)70-41(57(87)72-46(29(2)75)59(89)90)26-96-95-25-40(69-53(83)37(19-30-10-4-3-5-11-30)65-27-61(91)51(81)50(43(77)24-92-61)94-60-49(80)48(79)47(78)44(23-73)93-60)56(86)67-38(20-31-15-16-42(76)34(62)18-31)54(84)68-39(21-32-22-64-35-13-7-6-12-33(32)35)55(85)66-36(52(82)71-45)14-8-9-17-63/h3-7,10-13,15-16,18,22,28-29,36-41,43-51,60,64-65,73-81,91H,8-9,14,17,19-21,23-27,63H2,1-2H3,(H,66,85)(H,67,86)(H,68,84)(H,69,83)(H,70,88)(H,71,82)(H,72,87)(H,89,90)/t28-,29-,36+,37+,38+,39-,40+,41+,43+,44+,45+,46+,47-,48+,49+,50-,51+,60+,61+/m1/s1",RXSDHHRIGJKEOJ-GZJBUCRJSA-N,"c(""Somatostatin receptor 1"", ""Somatostatin receptor 2"", ""Somatostatin receptor 3"", ""Somatostatin receptor 4"", ""Somatostatin receptor 5"")",6752,SSR2,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,IEA GO:0005737 cytoplasm TAS GO:0005886 plasma membrane 7914078 TAS GO:0005887 integral component of plasma membrane IBA GO:0043005 neuron projection,"GO:0006937 regulation of muscle contraction IEA 7914078 GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA GO:0007218 neuropeptide signaling pathway IEA 1346068 GO:0007267 cell-cell signaling TAS GO:0007268 chemical synaptic transmission IBA GO:0007283 spermatogenesis IEA 1346068 GO:0007584 response to nutrient TAS 1346068 GO:0007586 digestion TAS 9892014 GO:0008285 negative regulation of cell proliferation TAS GO:0021549 cerebellum development IEA GO:0030432 peristalsis IEA GO:0030900 forebrain development IEA GO:0038170 somatostatin signaling pathway IEA GO:0042594 response to starvation IEA GO:0071385 cellular response to glucocorticoid stimulus IBA GO:0071392 cellular response to estradiol stimulus IBA",somatostatin receptor activity GO:0004994 IEA protein binding GO:0005515 IPI 10551867 16917505 22651821 PDZ domain binding GO:0030165 IPI 10551867 neuropeptide binding GO:0042923 IBA,hsa04024 cAMP signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04971 Gastric acid secretion - Homo sapiens (human),CHEMBL CHEMBL2069499,P32745,Somatostatin receptor 3,1.0,ORTHOGONAL,NO,CCCCC1(CCCC)N[C@H](Cc2c1[nH]c3ccccc23)c4nc(c[nH]4)c5ccccc5,5,12,"InChI=1S/C28H34N4/c1-3-5-16-28(17-6-4-2)26-22(21-14-10-11-15-23(21)30-26)18-24(32-28)27-29-19-25(31-27)20-12-8-7-9-13-20/h7-15,19,24,30,32H,3-6,16-18H2,1-2H3,(H,29,31)/t24-/m1/s1",FOBFICSYUINKAA-XMMPIXPASA-N,"c(""Somatostatin receptor 3"", ""Somatostatin receptor 1"", ""Somatostatin receptor 2"", ""Somatostatin receptor 4"", ""Somatostatin receptor 5"", ""Unchecked"")",6753,SSR3,R-HSA-162582 Signal Transduction R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding R-HSA-5617833 Assembly of the primary cilium R-HSA-5620920 Cargo trafficking to the periciliary membrane R-HSA-5620922 BBSome-mediated cargo-targeting to cilium,cytoplasm GO:0005737 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 1337145 TAS nonmotile primary cilium GO:0031513 ISS neuron projection GO:0043005 IBA ciliary membrane GO:0060170 TAS,"G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8405411 GO:0007187 cell-cell signaling TAS 1337145 GO:0007267 chemical synaptic transmission IBA GO:0007268 spermatogenesis IEA GO:0007283 negative regulation of cell proliferation TAS 8961277 GO:0008285 hormone-mediated apoptotic signaling pathway TAS 8961277 GO:0008628 cerebellum development IEA GO:0021549 forebrain development IEA GO:0030900 somatostatin signaling pathway IEA GO:0038170 response to starvation IEA GO:0042594 cellular response to glucocorticoid stimulus IEA GO:0071385 cellular response to estradiol stimulus IEA GO:0071392",IEA GO:0004994 somatostatin receptor activity IEA GO:0005102 receptor binding IPI 19071123 22651821 protein binding GO:0005515 IBA GO:0042923 neuropeptide binding,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL2204935,P32745,Somatostatin receptor 3,1.0,PRIMARY,NO,Cc1onc(n1)[C@@]2(N[C@H](Cc3c2[nH]c4ccccc34)c5nc(c[nH]5)c6ccc(F)cc6)c7cnn(C)c7,5,24,"InChI=1S/C27H23FN8O/c1-15-31-26(35-37-15)27(17-12-30-36(2)14-17)24-20(19-5-3-4-6-21(19)32-24)11-22(34-27)25-29-13-23(33-25)16-7-9-18(28)10-8-16/h3-10,12-14,22,32,34H,11H2,1-2H3,(H,29,33)/t22-,27-/m1/s1",NTIFDLOQPKMIJK-AJTFRIOCSA-N,"c(""Somatostatin receptor 3"", ""Unchecked"", ""Somatostatin receptor 5"", ""Somatostatin receptor 4"", ""Somatostatin receptor 2"", ""Somatostatin receptor 1"")",6753,SSR3,R-HSA-162582 Signal Transduction R-HSA-1852241 Organelle biogenesis and maintenance R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-500792 GPCR ligand binding R-HSA-5617833 Assembly of the primary cilium R-HSA-5620920 Cargo trafficking to the periciliary membrane R-HSA-5620922 BBSome-mediated cargo-targeting to cilium,cytoplasm GO:0005737 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 1337145 TAS nonmotile primary cilium GO:0031513 ISS neuron projection GO:0043005 IBA ciliary membrane GO:0060170 TAS,"G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS 8405411 GO:0007187 cell-cell signaling TAS 1337145 GO:0007267 chemical synaptic transmission IBA GO:0007268 spermatogenesis IEA GO:0007283 negative regulation of cell proliferation TAS 8961277 GO:0008285 hormone-mediated apoptotic signaling pathway TAS 8961277 GO:0008628 cerebellum development IEA GO:0021549 forebrain development IEA GO:0030900 somatostatin signaling pathway IEA GO:0038170 response to starvation IEA GO:0042594 cellular response to glucocorticoid stimulus IEA GO:0071385 cellular response to estradiol stimulus IEA GO:0071392",IEA GO:0004994 somatostatin receptor activity IEA GO:0005102 receptor binding IPI 19071123 22651821 protein binding GO:0005515 IBA GO:0042923 neuropeptide binding,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL3421842,P31391,Somatostatin receptor 4,1.0,PRIMARY,NO,Cc1cc2ccccc2c(n1)C(C)(C)NC(=O)[C@H]3[C@@H]4CNC[C@H]34,5,6,"InChI=1S/C19H23N3O/c1-11-8-12-6-4-5-7-13(12)17(21-11)19(2,3)22-18(23)16-14-9-20-10-15(14)16/h4-8,14-16,20H,9-10H2,1-3H3,(H,22,23)/t14-,15+,16+",GSKQCADKMBMWTN-ZSHCYNCHSA-N,"c(""Somatostatin receptor 1"", ""Somatostatin receptor 4"", ""Somatostatin receptor 5"", ""Somatostatin receptor 3"", ""Somatostatin receptor 2"")",6754,SSR4,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,cytoplasm GO:0005737 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane 8100352 GO:0005887 TAS neuron projection GO:0043005 IBA,"GO:0007186 G-protein coupled receptor signaling pathway 9892014 TAS GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 8405411 TAS GO:0007268 chemical synaptic transmission IBA GO:0008285 negative regulation of cell proliferation 9892014 TAS GO:0016477 cell migration IEA GO:0019369 arachidonic acid metabolic process IEA GO:0030815 negative regulation of cAMP metabolic process IEA GO:0030900 forebrain development IEA GO:0038170 somatostatin signaling pathway IEA GO:0043410 positive regulation of MAPK cascade IEA GO:0071385 cellular response to glucocorticoid stimulus IBA",IEA GO:0004994 somatostatin receptor activity IBA GO:0042923 neuropeptide binding,hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL1080585,P35346,Somatostatin receptor 5,1.0,ORTHOGONAL,NO,CCOc1cc(CN2CCC(CC2)Nc3oc4ccc(cc4n3)C(=O)O)cc(OCC)c1Cl,5,7,"InChI=1S/C24H28ClN3O5/c1-3-31-20-11-15(12-21(22(20)25)32-4-2)14-28-9-7-17(8-10-28)26-24-27-18-13-16(23(29)30)5-6-19(18)33-24/h5-6,11-13,17H,3-4,7-10,14H2,1-2H3,(H,26,27)(H,29,30)",DDDLCIAZEXUUFD-UHFFFAOYSA-N,"c(""Somatostatin receptor 5"", ""Somatostatin receptor 1"", ""Unchecked"", ""Somatostatin receptor 2"", ""Somatostatin receptor 3"", ""Somatostatin receptor 4"")",6755,SSR5,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,GO:0005634 nucleus IDA GO:0005737 cytoplasm IEA GO:0005886 plasma membrane IDA GO:0005886 plasma membrane TAS 7908405 GO:0005887 integral component of plasma membrane TAS GO:0043005 neuron projection IBA,"G-protein coupled receptor signaling pathway GO:0007186 TAS 9892014 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 TAS 7908405 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 IEA chemical synaptic transmission GO:0007268 IBA negative regulation of cell proliferation GO:0008285 TAS 9892014 positive regulation of cytokinesis GO:0032467 IMP 22888021 somatostatin signaling pathway GO:0038170 IEA glucose homeostasis GO:0042593 IEA regulation of insulin secretion GO:0050796 IBA cellular response to glucocorticoid stimulus GO:0071385 IBA",somatostatin receptor activity GO:0004994 IEA neuropeptide binding GO:0042923 IBA,cAMP signaling pathway - Homo sapiens (human) hsa04024 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL236788,P35346,Somatostatin receptor 5,1.0,PRIMARY,NO,CCOc1cc(CN2CCC(CC2)Nc3oc4ccc(cc4n3)S(=O)(=O)N)cc(OCC)c1N,6,15,"InChI=1S/C23H31N5O5S/c1-3-31-20-11-15(12-21(22(20)24)32-4-2)14-28-9-7-16(8-10-28)26-23-27-18-13-17(34(25,29)30)5-6-19(18)33-23/h5-6,11-13,16H,3-4,7-10,14,24H2,1-2H3,(H,26,27)(H2,25,29,30)",OFGZKSUTEKHHAS-UHFFFAOYSA-N,"c(""Somatostatin receptor 5"", ""Unchecked"", ""Somatostatin receptor 1"", ""Somatostatin receptor 2"", ""Somatostatin receptor 3"", ""Somatostatin receptor 4"", ""Histamine H1 receptor"")",6755,SSR5,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 GPCR ligand binding R-HSA-500792,GO:0005634 nucleus IDA GO:0005737 cytoplasm IEA GO:0005886 plasma membrane IDA GO:0005886 plasma membrane TAS 7908405 GO:0005887 integral component of plasma membrane TAS GO:0043005 neuron projection IBA,"G-protein coupled receptor signaling pathway GO:0007186 TAS 9892014 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 TAS 7908405 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007193 IEA chemical synaptic transmission GO:0007268 IBA negative regulation of cell proliferation GO:0008285 TAS 9892014 positive regulation of cytokinesis GO:0032467 IMP 22888021 somatostatin signaling pathway GO:0038170 IEA glucose homeostasis GO:0042593 IEA regulation of insulin secretion GO:0050796 IBA cellular response to glucocorticoid stimulus GO:0071385 IBA",somatostatin receptor activity GO:0004994 IEA neuropeptide binding GO:0042923 IBA,cAMP signaling pathway - Homo sapiens (human) hsa04024 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL210352,P21453,Sphingosine 1-phosphate receptor Edg-1,1.0,ORTHOGONAL,NO,CC(C)Cc1ccc(cc1)c2onc(n2)c3ccc(cc3)[C@H]4CC[C@@H](CC(=O)O)N4,5,5,"InChI=1S/C24H27N3O3/c1-15(2)13-16-3-5-19(6-4-16)24-26-23(27-30-24)18-9-7-17(8-10-18)21-12-11-20(25-21)14-22(28)29/h3-10,15,20-21,25H,11-14H2,1-2H3,(H,28,29)/t20-,21+/m0/s1",SJSQQBATFXLXQC-LEWJYISDSA-N,"c(""Sphingosine 1-phosphate receptor Edg-5"", ""Sphingosine 1-phosphate receptor Edg-1"", ""Sphingosine 1-phosphate receptor Edg-3"", ""Sphingosine 1-phosphate receptor Edg-6"", ""Sphingosine 1-phosphate receptor Edg-8"")",1901,S1PR1,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-419408 Lysosphingolipid and LPA receptors R-HSA-500792 GPCR ligand binding,endosome IEA GO:0005768 cytosol IEA GO:0005829 plasma membrane TAS GO:0005886 external side of plasma membrane IEA GO:0009897 integral component of membrane IEA GO:0016021 intrinsic component of plasma membrane IDA 22344443 GO:0031226 membrane raft IEA GO:0045121,IEA GO:0001525 angiogenesis ISS GO:0001955 blood vessel maturation ISS GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis IDA 22344443 sphingosine-1-phosphate signaling pathway GO:0003376 ISS GO:0006935 chemotaxis TAS 9488656 10555146 cell adhesion GO:0007155 TAS 8626678 G-protein coupled receptor signaling pathway GO:0007186 IEA GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA GO:0007420 brain development ISS GO:0016477 cell migration IEA GO:0019226 transmission of nerve impulse ISS GO:0030032 lamellipodium assembly IEA GO:0030155 regulation of cell adhesion IEA GO:0030182 neuron differentiation IEA GO:0030335 positive regulation of cell migration ISS GO:0030500 regulation of bone mineralization ISS GO:0031532 actin cytoskeleton reorganization IEA GO:0043547 positive regulation of GTPase activity ISS GO:0045124 regulation of bone resorption IEA GO:0045446 endothelial cell differentiation IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0048661 positive regulation of smooth muscle cell proliferation IEA GO:0050927 positive regulation of positive chemotaxis IEA GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA GO:0051497 negative regulation of stress fiber assembly ISS GO:0061384 heart trabecula morphogenesis ISS GO:0072678 T cell migration,G-protein coupled receptor binding 24851274 GO:0001664 IPI G-protein coupled receptor activity 8626678 GO:0004930 TAS sphingosine-1-phosphate receptor activity 22344443 GO:0038036 IDA sphingolipid binding GO:0046625 IEA,FoxO signaling pathway - Homo sapiens (human) hsa04068 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL377855,P21453,Sphingosine 1-phosphate receptor Edg-1,1.0,PRIMARY,NO,OC(=O)CC1CNC(C1)c2ccc(OCc3cc(c4ccccc4)c(s3)C(F)(F)F)cc2,5,6,"InChI=1S/C24H22F3NO3S/c25-24(26,27)23-20(16-4-2-1-3-5-16)12-19(32-23)14-31-18-8-6-17(7-9-18)21-10-15(13-28-21)11-22(29)30/h1-9,12,15,21,28H,10-11,13-14H2,(H,29,30)",UNTMCOZQSGVJBE-UHFFFAOYSA-N,"c(""PBL"", ""Sphingosine 1-phosphate receptor Edg-8"", ""Sphingosine 1-phosphate receptor Edg-6"", ""Sphingosine 1-phosphate receptor Edg-3"", ""Sphingosine 1-phosphate receptor Edg-5"", ""Sphingosine 1-phosphate receptor Edg-1"")",1901,S1PR1,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-419408 Lysosphingolipid and LPA receptors R-HSA-500792 GPCR ligand binding,endosome IEA GO:0005768 cytosol IEA GO:0005829 plasma membrane TAS GO:0005886 external side of plasma membrane IEA GO:0009897 integral component of membrane IEA GO:0016021 intrinsic component of plasma membrane IDA 22344443 GO:0031226 membrane raft IEA GO:0045121,IEA GO:0001525 angiogenesis ISS GO:0001955 blood vessel maturation ISS GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis IDA 22344443 sphingosine-1-phosphate signaling pathway GO:0003376 ISS GO:0006935 chemotaxis TAS 9488656 10555146 cell adhesion GO:0007155 TAS 8626678 G-protein coupled receptor signaling pathway GO:0007186 IEA GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA GO:0007420 brain development ISS GO:0016477 cell migration IEA GO:0019226 transmission of nerve impulse ISS GO:0030032 lamellipodium assembly IEA GO:0030155 regulation of cell adhesion IEA GO:0030182 neuron differentiation IEA GO:0030335 positive regulation of cell migration ISS GO:0030500 regulation of bone mineralization ISS GO:0031532 actin cytoskeleton reorganization IEA GO:0043547 positive regulation of GTPase activity ISS GO:0045124 regulation of bone resorption IEA GO:0045446 endothelial cell differentiation IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0048661 positive regulation of smooth muscle cell proliferation IEA GO:0050927 positive regulation of positive chemotaxis IEA GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA GO:0051497 negative regulation of stress fiber assembly ISS GO:0061384 heart trabecula morphogenesis ISS GO:0072678 T cell migration,G-protein coupled receptor binding 24851274 GO:0001664 IPI G-protein coupled receptor activity 8626678 GO:0004930 TAS sphingosine-1-phosphate receptor activity 22344443 GO:0038036 IDA sphingolipid binding GO:0046625 IEA,FoxO signaling pathway - Homo sapiens (human) hsa04068 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL224720,P21453,Sphingosine 1-phosphate receptor Edg-1,1.0,PRIMARY,YES,FC(F)(F)c1cccc(c1)c2noc(n2)c3cc(c4ccccc4)c(s3)C(F)(F)F,5,11,"InChI=1S/C20H10F6N2OS/c21-19(22,23)13-8-4-7-12(9-13)17-27-18(29-28-17)15-10-14(11-5-2-1-3-6-11)16(30-15)20(24,25)26/h1-10H",OYMNPJXKQVTQTR-UHFFFAOYSA-N,"c(""Sphingosine 1-phosphate receptor Edg-1"", ""Sphingosine 1-phosphate receptor Edg-5"", ""Sphingosine 1-phosphate receptor Edg-3"", ""Sphingosine 1-phosphate receptor Edg-6"", ""Sphingosine 1-phosphate receptor Edg-8"", ""Arachidonate 15-lipoxygenase"", ""DNA polymerase kappa"")",1901,S1PR1,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-388396 GPCR downstream signaling R-HSA-418594 G alpha (i) signalling events R-HSA-419408 Lysosphingolipid and LPA receptors R-HSA-500792 GPCR ligand binding,endosome IEA GO:0005768 cytosol IEA GO:0005829 plasma membrane TAS GO:0005886 external side of plasma membrane IEA GO:0009897 integral component of membrane IEA GO:0016021 intrinsic component of plasma membrane IDA 22344443 GO:0031226 membrane raft IEA GO:0045121,IEA GO:0001525 angiogenesis ISS GO:0001955 blood vessel maturation ISS GO:0003245 cardiac muscle tissue growth involved in heart morphogenesis IDA 22344443 sphingosine-1-phosphate signaling pathway GO:0003376 ISS GO:0006935 chemotaxis TAS 9488656 10555146 cell adhesion GO:0007155 TAS 8626678 G-protein coupled receptor signaling pathway GO:0007186 IEA GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA GO:0007420 brain development ISS GO:0016477 cell migration IEA GO:0019226 transmission of nerve impulse ISS GO:0030032 lamellipodium assembly IEA GO:0030155 regulation of cell adhesion IEA GO:0030182 neuron differentiation IEA GO:0030335 positive regulation of cell migration ISS GO:0030500 regulation of bone mineralization ISS GO:0031532 actin cytoskeleton reorganization IEA GO:0043547 positive regulation of GTPase activity ISS GO:0045124 regulation of bone resorption IEA GO:0045446 endothelial cell differentiation IEA GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA GO:0048661 positive regulation of smooth muscle cell proliferation IEA GO:0050927 positive regulation of positive chemotaxis IEA GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA GO:0051497 negative regulation of stress fiber assembly ISS GO:0061384 heart trabecula morphogenesis ISS GO:0072678 T cell migration,G-protein coupled receptor binding 24851274 GO:0001664 IPI G-protein coupled receptor activity 8626678 GO:0004930 TAS sphingosine-1-phosphate receptor activity 22344443 GO:0038036 IDA sphingolipid binding GO:0046625 IEA,FoxO signaling pathway - Homo sapiens (human) hsa04068 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080,CHEMBL CHEMBL3401388,O95136,Sphingosine 1-phosphate receptor Edg-5,1.0,PRIMARY,NO,CCC(CC)CC1(O)CCN(CC1)C(=O)Nc2cc(Oc3ccncc3)cc(Oc4ccc(F)cc4)c2,5,9,"InChI=1S/C29H34FN3O4/c1-3-21(4-2)20-29(35)11-15-33(16-12-29)28(34)32-23-17-26(36-24-7-5-22(30)6-8-24)19-27(18-23)37-25-9-13-31-14-10-25/h5-10,13-14,17-19,21,35H,3-4,11-12,15-16,20H2,1-2H3,(H,32,34)",BGDQNJZBOQYYEC-UHFFFAOYSA-N,"c(""Sphingosine 1-phosphate receptor Edg-5"", ""Lysophosphatidic acid receptor Edg-2"", ""Sphingosine 1-phosphate receptor Edg-3"", ""Lysophosphatidic acid receptor Edg-4"", ""Sphingosine 1-phosphate receptor Edg-1"", ""Sphingosine 1-phosphate receptor Edg-6"", ""Sphingosine 1-phosphate receptor Edg-8"")",9294,S1PR2,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 GPCR downstream signaling R-HSA-388396 G alpha (i) signalling events R-HSA-418594 Lysosphingolipid and LPA receptors R-HSA-419408 GPCR ligand binding R-HSA-500792,GO:0005886 plasma membrane 24851274 IDA GO:0005886 plasma membrane TAS GO:0016021 integral component of membrane IEA,10617617 TAS GO:0000187 activation of MAPK activity 23106337 IMP GO:0003376 sphingosine-1-phosphate signaling pathway 10617617 TAS GO:0007186 G-protein coupled receptor signaling pathway 10617617 TAS GO:0008284 positive regulation of cell proliferation 23106337 IMP GO:0010800 positive regulation of peptidyl-threonine phosphorylation 23106337 IMP GO:0031532 actin cytoskeleton reorganization 23106337 IMP GO:0046847 filopodium assembly IEA GO:0090394 negative regulation of excitatory postsynaptic potential 24851274 IMP GO:1903142 positive regulation of establishment of endothelial barrier,24851274 GO:0001664 G-protein coupled receptor binding IPI 8087418 GO:0004930 G-protein coupled receptor activity TAS 24851274 GO:0005178 integrin binding IPI 24851274 GO:0005515 protein binding IPI 10617617 GO:0008289 lipid binding TAS 23106337 GO:0038036 sphingosine-1-phosphate receptor activity IMP,hsa04071 Sphingolipid signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human),CHEMBL CHEMBL2407198,Q9NYA1,Sphingosine kinase 1,1.0,PRIMARY,NO,OC[C@H]1C[C@@H](O)CCN1CCc2ccc(Nc3nc(cs3)C4CCCCC4)cc2,2,4,"InChI=1S/C23H33N3O2S/c27-15-20-14-21(28)11-13-26(20)12-10-17-6-8-19(9-7-17)24-23-25-22(16-29-23)18-4-2-1-3-5-18/h6-9,16,18,20-21,27-28H,1-5,10-15H2,(H,24,25)/t20-,21+/m1/s1",LRTJNSSXHCYTOU-RTWAWAEBSA-N,"c(""Unchecked"", ""Sphingosine kinase 2"", ""Sphingosine kinase 1"")",8877,SPHK1,R-HSA-1430728 Metabolism R-HSA-162582 Signal Transduction R-HSA-1660661 Sphingolipid de novo biosynthesis R-HSA-194138 Signaling by VEGF R-HSA-390466 Chaperonin-mediated protein folding R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis R-HSA-391251 Protein folding R-HSA-392499 Metabolism of proteins R-HSA-428157 Sphingolipid metabolism R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-5218921 VEGFR2 mediated cell proliferation R-HSA-556833 Metabolism of lipids and lipoproteins,nucleus GO:0005634 IEA cytoplasm GO:0005737 IDA 15623571 19854831 21075214 cytosol GO:0005829 TAS 10863092 plasma membrane GO:0005886 IDA 19854831 21075214 synaptic vesicle GO:0008021 IEA axon GO:0030424 IEA,blood vessel development GO:0001568 IEA positive regulation of neurotransmitter secretion GO:0001956 IEA sphingosine-1-phosphate signaling pathway GO:0003376 IEA protein folding GO:0006457 TAS sphingosine metabolic process GO:0006670 20577214 IDA inflammatory response GO:0006954 IEA signal transduction GO:0007165 10751414 TAS brain development GO:0007420 IEA female pregnancy GO:0007565 IEA cellular response to starvation GO:0009267 IEA positive regulation of peptidyl-threonine phosphorylation GO:0010800 23106337 IMP regulation of tumor necrosis factor-mediated signaling pathway GO:0010803 20577214 IDA positive regulation of neuron projection development GO:0010976 IEA response to amine GO:0014075 IEA cyclooxygenase pathway GO:0019371 IEA calcium-mediated signaling GO:0019722 10947957 IDA sphingolipid biosynthetic process GO:0030148 TAS positive regulation of cell growth GO:0030307 12441135 IDA positive regulation of cell migration GO:0030335 12441135 IDA positive regulation of protein ubiquitination GO:0031398 20577214 IDA response to magnesium ion GO:0032026 IEA response to progesterone GO:0032570 IEA regulation of interleukin-1 beta production GO:0032651 IEA response to ATP GO:0033198 IEA intracellular signal transduction GO:0035556 10947957 TAS positive regulation of NF-kappaB import into nucleus GO:0042346 20577214 IMP negative regulation of apoptotic process GO:0043066 15623571 IDA negative regulation of apoptotic process GO:0043066 10947957 TAS positive regulation of angiogenesis GO:0045766 12441135 IDA positive regulation of mitotic cell cycle GO:0045931 12441135 IDA positive regulation of smooth muscle contraction GO:0045987 12847068 IDA sphingosine biosynthetic process GO:0046512 23106337 IGI sphingosine biosynthetic process GO:0046512 23106337 IMP sphingoid catabolic process GO:0046521 10863092 NAS lipid phosphorylation GO:0046834 IEA positive regulation of fibroblast proliferation GO:0048146 15623571 IDA positive regulation of NF-kappaB transcription factor activity GO:0051092 20577214 IMP cellular response to hydrogen peroxide GO:0070301 IEA response to interleukin-1 GO:0070555 IEA cellular response to growth factor stimulus GO:0071363 IEA,magnesium ion binding IDA 10947957 GO:0000287 magnesium ion binding ISS GO:0000287 DNA binding IDA 12393916 GO:0003677 protein binding IPI 12080051 16888242 17064696 17124500 19854831 20838377 GO:0005515 calmodulin binding IDA 10947957 12393916 GO:0005516 ATP binding IDA 12393916 GO:0005524 sphinganine kinase activity IDA 12393916 15623571 GO:0008481 sphinganine kinase activity TAS GO:0008481 D-erythro-sphingosine kinase activity IDA 10863092 20577214 GO:0017050 D-erythro-sphingosine kinase activity TAS GO:0017050 sphingosine-1-phosphate receptor activity IMP 23106337 GO:0038036 protein phosphatase 2A binding IPI 21075214 GO:0051721,Sphingolipid metabolism - Homo sapiens (human) hsa00600 Calcium signaling pathway - Homo sapiens (human) hsa04020 Sphingolipid signaling pathway - Homo sapiens (human) hsa04071 VEGF signaling pathway - Homo sapiens (human) hsa04370 Fc gamma R-mediated phagocytosis - Homo sapiens (human) hsa04666 Tuberculosis - Homo sapiens (human) hsa05152,CHEMBL CHEMBL118446,P18405,Steroid 5-alpha-reductase 1,1.0,PRIMARY,NO,CC1=C2CCc3cc(Cl)ccc3N2CCC1=O,2,6,"InChI=1S/C14H14ClNO/c1-9-12-4-2-10-8-11(15)3-5-13(10)16(12)7-6-14(9)17/h3,5,8H,2,4,6-7H2,1H3",DWGUKGCMIQALCV-UHFFFAOYSA-N,"c(""Steroid 5-alpha-reductase 1"", ""Steroid 5-alpha-reductase 2"")",6715,S5A1,Metabolism R-HSA-1430728 Androgen biosynthesis R-HSA-193048 Metabolism of steroid hormones and vitamin D R-HSA-196071 Steroid hormones R-HSA-209943 Metabolism of lipids and lipoproteins R-HSA-556833,TAS GO:0005789 endoplasmic reticulum membrane IEA GO:0016021 integral component of membrane IEA GO:0043025 neuronal cell body IEA GO:0043209 myelin sheath IEA GO:0048471 perinuclear region of cytoplasm IEA GO:0070852 cell body fiber,"urogenital system development GO:0001655 IEA liver development GO:0001889 IEA androgen biosynthetic process GO:0006702 TAS sex determination 1686016 GO:0007530 NAS male gonad development GO:0008584 IEA cellular response to starvation GO:0009267 IEA response to muscle activity GO:0014850 IEA diterpenoid metabolic process GO:0016101 IEA spinal cord development GO:0021510 IEA hippocampus development GO:0021766 IEA thalamus development GO:0021794 IEA hypothalamus development GO:0021854 IEA pituitary gland development GO:0021983 IEA cerebral cortex development GO:0021987 IEA cell differentiation GO:0030154 IEA male genitalia development GO:0030539 IEA female genitalia development GO:0030540 IEA response to follicle-stimulating hormone GO:0032354 IEA cellular response to insulin stimulus GO:0032869 IEA serotonin metabolic process GO:0042428 IEA progesterone metabolic process GO:0042448 IEA response to drug GO:0042493 IEA circadian sleep/wake cycle, REM sleep GO:0042747 IEA oxidation-reduction process GO:0055114 IEA bone development GO:0060348 IEA response to growth hormone GO:0060416 IEA response to fungicide GO:0060992 IEA cellular response to cAMP GO:0071320 IEA cellular response to growth factor stimulus GO:0071363 IEA cellular response to estradiol stimulus GO:0071392 IEA cellular response to testosterone stimulus GO:0071394 IEA cellular response to dexamethasone stimulus GO:0071549 IEA cellular response to epinephrine stimulus GO:0071872 IEA",GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity 17986282 IDA GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity TAS GO:0009055 electron carrier activity 1686016 TAS GO:0033218 amide binding IEA GO:0047751 cholestenone 5-alpha-reductase activity IEA GO:0070402 NADPH binding IEA,hsa00140 Steroid hormone biosynthesis - Homo sapiens (human),CHEMBL CHEMBL710,P31213,Steroid 5-alpha-reductase 2,1.0,PRIMARY,NO,CC(C)(C)NC(=O)[C@H]1CC[C@H]2[C@@H]3CC[C@H]4NC(=O)C=C[C@]4(C)[C@H]3CC[C@]12C,4,133,"InChI=1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1",DBEPLOCGEIEOCV-WSBQPABSSA-N,"c(""Steroid 5-alpha-reductase 1"", ""Steroid 5-alpha-reductase 2"", ""3-beta-hydroxysteroid dehydrogenase/delta 5-->4-isomerase type I"", ""Unchecked"", ""3-keto-steroid reductase"", ""DU-145"", ""Prelamin-A/C"", ""Nuclear factor NF-kappa-B p105 subunit"", ""MAP kinase ERK2"", ""Bloom syndrome protein"", ""Thrombopoietin"", ""Histone-lysine N-methyltransferase, H3 lysine-9 specific 3"", ""Geminin"", ""Androgen Receptor"", ""Nuclear factor erythroid 2-related factor 2"", ""Peroxisome proliferator-activated receptor delta"")",6716,S5A2,Metabolism R-HSA-1430728 Androgen biosynthesis R-HSA-193048 Metabolism of steroid hormones and vitamin D R-HSA-196071 Steroid hormones R-HSA-209943 Metabolism of lipids and lipoproteins R-HSA-556833,TAS GO:0005789 endoplasmic reticulum membrane IEA GO:0016021 integral component of membrane IEA GO:0043025 neuronal cell body IEA GO:0070852 cell body fiber,GO:0006702 androgen biosynthetic process TAS GO:0006706 steroid catabolic process IEA 1944596 GO:0007267 cell-cell signaling TAS 1944596 GO:0008209 androgen metabolic process IDA 1944596 GO:0008584 male gonad development IMP GO:0018879 biphenyl metabolic process IEA GO:0018894 dibenzo-p-dioxin metabolic process IEA GO:0018963 phthalate metabolic process IEA GO:0021766 hippocampus development IEA GO:0021854 hypothalamus development IEA GO:0030154 cell differentiation IEA GO:0030539 male genitalia development IEA GO:0030540 female genitalia development IEA GO:0031667 response to nutrient levels IEA GO:0032354 response to follicle-stimulating hormone IEA GO:0033574 response to testosterone IEA GO:0042493 response to drug IEA GO:0043434 response to peptide hormone IEA GO:0055114 oxidation-reduction process IEA GO:0060348 bone development IEA,3-oxo-5-alpha-steroid 4-dehydrogenase activity GO:0003865 TAS sterol 5-alpha reductase activity GO:0009917 IDA 1944596 amide binding GO:0033218 IEA cholestenone 5-alpha-reductase activity GO:0047751 IEA,hsa00140 Steroid hormone biosynthesis - Homo sapiens (human) hsa05215 Prostate cancer - Homo sapiens (human),CHEMBL CHEMBL3235682,P08842,Steryl-sulfatase,1.0,PRIMARY,NO,NS(=O)(=O)Oc1ccc(Sc2ccc(OS(=O)(=O)N)cc2)cc1,3,8,"InChI=1S/C12H12N2O6S3/c13-22(15,16)19-9-1-5-11(6-2-9)21-12-7-3-10(4-8-12)20-23(14,17)18/h1-8H,(H2,13,15,16)(H2,14,17,18)",HRUVZHPJVFCBHT-UHFFFAOYSA-N,"c(""Steryl-sulfatase"", ""Estrogen receptor alpha"", ""Estrogen receptor beta"")",412,STS,"Metabolism R-HSA-1430728 Gamma carboxylation, hypusine formation and arylsulfatase activation R-HSA-163841 Glycosphingolipid metabolism R-HSA-1660662 The activation of arylsulfatases R-HSA-1663150 Metabolism of proteins R-HSA-392499 Sphingolipid metabolism R-HSA-428157 Metabolism of lipids and lipoproteins R-HSA-556833 Post-translational protein modification R-HSA-597592",nuclear envelope GO:0005635 IEA lysosome GO:0005764 2668275 TAS endosome GO:0005768 2668275 TAS endoplasmic reticulum GO:0005783 2668275 TAS endoplasmic reticulum lumen GO:0005788 TAS endoplasmic reticulum membrane GO:0005789 TAS Golgi apparatus GO:0005794 2668275 TAS plasma membrane GO:0005886 2668275 TAS membrane GO:0016020 2668275 TAS integral component of membrane GO:0016021 IEA intracellular membrane-bounded organelle GO:0043231 6957717 TAS,glycosphingolipid metabolic process TAS GO:0006687 steroid catabolic process TAS 6957717 GO:0006706 female pregnancy IEA GO:0007565 learning or memory IEA GO:0007611 positive regulation of cell proliferation IEA GO:0008284 epidermis development TAS 9252398 GO:0008544 response to pH IEA GO:0009268 response to peptide hormone IEA GO:0043434 skin development IEA GO:0043588 response to estrogen IEA GO:0043627 post-translational protein modification TAS GO:0043687,TAS GO:0004773 steryl-sulfatase activity IDA 15962010 sulfuric ester hydrolase activity GO:0008484 IEA GO:0046872 metal ion binding,Steroid hormone biosynthesis - Homo sapiens (human) hsa00140,CHEMBL CHEMBL2179834,P29122,Subtilisin/kexin type 6,1.0,PRIMARY,NO,CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N,2,12,"InChI=1S/C49H94N16O9/c1-26(2)22-35(58-31(11)66)43(70)62-37(24-28(5)6)45(72)64-38(25-29(7)8)46(73)63-36(23-27(3)4)44(71)60-34(18-15-21-57-49(54)55)42(69)65-39(30(9)10)47(74)61-33(16-12-13-19-50)41(68)59-32(40(51)67)17-14-20-56-48(52)53/h26-30,32-39H,12-25,50H2,1-11H3,(H2,51,67)(H,58,66)(H,59,68)(H,60,71)(H,61,74)(H,62,70)(H,63,73)(H,64,72)(H,65,69)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35+,36-,37-,38-,39-/m0/s1",ZOSNPKYKQJPYEO-OZKMNFSDSA-N,"c(""LNCaP"", ""DU-145"", ""Unchecked"", ""Furin"", ""Subtilisin/kexin type 6"")",5046,PCSK6,R-HSA-1181150 Signaling by NODAL R-HSA-1266738 Developmental Biology R-HSA-162582 Signal Transduction R-HSA-166520 Signalling by NGF R-HSA-167060 NGF processing,extracellular space 8906861 GO:0005615 IDA endoplasmic reticulum GO:0005783 IEA Golgi lumen GO:0005796 TAS cell surface 12535616 GO:0009986 IDA membrane GO:0016020 IEA extracellular matrix 12535616 GO:0031012 IDA,"GO:0007354 zygotic determination of anterior/posterior axis, embryo IEA GO:0007368 determination of left/right symmetry IEA GO:0009100 glycoprotein metabolic process 8218226 IDA GO:0016485 protein processing 8218226 9242664 9738469 IDA GO:0016486 peptide hormone processing 9242664 IDA GO:0030510 regulation of BMP signaling pathway 10467177 TAS GO:0032455 nerve growth factor processing TAS GO:0032902 nerve growth factor production 8615794 IDA GO:0032940 secretion by cell 8615794 IDA",9242664 IDA GO:0004175 endopeptidase activity 8218226 8615794 8906861 IDA GO:0004252 serine-type endopeptidase activity 12535616 IDA GO:0008201 heparin binding 8615794 IDA GO:0048406 nerve growth factor binding,,CHEMBL CHEMBL1272,Q09428,Sulfonylurea receptor 1,1.0,PRIMARY,NO,CCOc1cc(CC(=O)N[C@@H](CC(C)C)c2ccccc2N3CCCCC3)ccc1C(=O)O,3,29,"InChI=1S/C27H36N2O4/c1-4-33-25-17-20(12-13-22(25)27(31)32)18-26(30)28-23(16-19(2)3)21-10-6-7-11-24(21)29-14-8-5-9-15-29/h6-7,10-13,17,19,23H,4-5,8-9,14-16,18H2,1-3H3,(H,28,30)(H,31,32)/t23-/m0/s1",FAEKWTJYAYMJKF-QHCPKHFHSA-N,"c(""Sulfonylurea receptor 1"", ""Homo sapiens"", ""Solute carrier family 22 member 1"", ""Unchecked"", ""Prelamin-A/C"", ""MAP kinase ERK2"", ""Nuclear factor erythroid 2-related factor 2"", ""Histone acetyltransferase GCN5"", ""P-glycoprotein 1"", ""Vitamin D receptor"", ""HepG2"", ""Androgen Receptor"", ""Rap guanine nucleotide exchange factor 4"", ""Guanine nucleotide-binding protein G(s), subunit alpha"")",6833,ABCC8,Neuronal System R-HSA-112316 ATP sensitive Potassium channels R-HSA-1296025 Inwardly rectifying K+ channels R-HSA-1296065 Potassium Channels R-HSA-1296071 Metabolism R-HSA-1430728 Integration of energy metabolism R-HSA-163685 Transmembrane transport of small molecules R-HSA-382551 ABC-family proteins mediated transport R-HSA-382556 Regulation of insulin secretion R-HSA-422356,GO:0005886 plasma membrane TAS 20610380 GO:0008076 voltage-gated potassium channel complex IDA GO:0030672 synaptic vesicle membrane IEA GO:0042383 sarcolemma IEA,potassium ion transport GO:0006813 TAS 7502040 signal transduction GO:0007165 IEA response to pH GO:0009268 IEA response to zinc ion GO:0010043 IEA response to lipopolysaccharide GO:0032496 IEA response to insulin GO:0032868 IEA response to drug GO:0042493 IEA positive regulation of potassium ion transport GO:0043268 IEA negative regulation of insulin secretion GO:0046676 IEA regulation of insulin secretion GO:0050796 TAS transmembrane transport GO:0055085 TAS cellular response to organic substance GO:0071310 IEA potassium ion transmembrane transport GO:0071805 IEA anion transmembrane transport GO:0098656 IEA,potassium channel activity GO:0005267 24814349 25720052 IMP ATP binding GO:0005524 IEA sulfonylurea receptor activity GO:0008281 IEA ATP-activated inward rectifier potassium channel activity GO:0015272 TAS syntaxin binding GO:0019905 IEA anion transmembrane-transporting ATPase activity GO:0043225 TAS ion channel binding GO:0044325 20610380 IPI,ABC transporters - Homo sapiens (human) hsa02010 Insulin secretion - Homo sapiens (human) hsa04911 Type II diabetes mellitus - Homo sapiens (human) hsa04930,CHEMBL CHEMBL336434,O14746,Telomerase reverse transcriptase,1.0,PRIMARY,NO,CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc5cc(NC(=O)CCN6CCCC6)ccc25)cc1,2,55,"InChI=1S/C35H43N7O2/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39)",RKPYSYRMIXRZJT-UHFFFAOYSA-N,"c(""Telomerase reverse transcriptase"", ""Unchecked"", ""Nucleic Acid"", ""IMR-90"", ""DU-145"", ""MCF7"", ""A549"", ""Protection of telomeres protein 1"", ""HGC-27"", ""HT-29"")",7015,TERT,R-HSA-157579 Telomere Maintenance R-HSA-162582 Signal Transduction R-HSA-1640170 Cell Cycle R-HSA-171319 Telomere Extension By Telomerase R-HSA-180786 Extension of Telomeres R-HSA-195721 Signaling by Wnt R-HSA-201681 TCF dependent signaling in response to WNT R-HSA-201722 formation of the beta-catenin:TCF transactivating complex R-HSA-73886 Chromosome Maintenance,"telomerase catalytic core complex IDA 9398860 9443919 16507993 17940095 18082603 GO:0000333 telomerase catalytic core complex IMP 11313459 GO:0000333 telomerase catalytic core complex IPI 19701182 GO:0000333 chromosome, telomeric region IC 12135483 GO:0000781 nuclear telomere cap complex IC 15632080 GO:0000783 nuclear chromosome, telomeric region IDA 25589350 GO:0000784 nucleus IDA 21829167 24415760 GO:0005634 nucleoplasm IDA 19567472 GO:0005654 nucleoplasm TAS GO:0005654 telomerase holoenzyme complex IDA 12135483 18082603 GO:0005697 telomerase holoenzyme complex IPI 19701182 GO:0005697 nucleolus IDA 22226966 GO:0005730 nucleolus NAS 26194824 GO:0005730 colocalizes_with PML body IDA 19567472 GO:0016605 RNA-directed RNA polymerase complex IPI 19701182 GO:0031379 mitochondrial nucleoid IDA 21937513 GO:0042645 TERT-RMRP complex IDA 19701182 GO:1990572","TAS 12135483 telomere maintenance GO:0000723 IDA 19701182 transcription, RNA-templated GO:0001172 IDA 9398860 RNA-dependent DNA biosynthetic process GO:0006278 IDA 9443919 16043710 17940095 19701182 21531765 telomere maintenance via telomerase GO:0007004 IMP 9454332 telomere maintenance via telomerase GO:0007004 NAS 2805070 telomere maintenance via telomerase GO:0007004 TAS GO:0007004 telomere maintenance via telomerase IDA 21937513 mitochondrion organization GO:0007005 IDA 11927518 negative regulation of gene expression GO:0010629 IDA 16043710 DNA strand elongation GO:0022616 IGI 19571879 positive regulation of Wnt signaling pathway GO:0030177 IDA 19701182 production of siRNA involved in RNA interference GO:0030422 IDA 24415760 26194824 regulation of protein stability GO:0031647 IMP 26194824 regulation of protein stability GO:0031647 IDA 24415760 positive regulation of protein binding GO:0032092 IDA 19701182 RNA biosynthetic process GO:0032774 IEA GO:0042635 positive regulation of hair cycle IDA 11927518 positive regulation of nitric-oxide synthase activity GO:0051000 IDA 25589350 establishment of protein localization to telomere GO:0070200 IMP 11313459 cellular response to hypoxia GO:0071456 IDA 9398860 19701182 DNA biosynthetic process GO:0071897 IMP 9454332 replicative senescence GO:0090399 IMP 25569094 positive regulation of pri-miRNA transcription from RNA polymerase II promoter GO:1902895 IDA 19701182 negative regulation of production of siRNA involved in RNA interference GO:1903704 IDA 24415760 positive regulation of protein localization to nucleolus GO:1904751 TAS GO:1904837 beta-catenin-TCF complex assembly IEA GO:2000648 positive regulation of stem cell proliferation IDA 11927518 negative regulation of cellular senescence GO:2000773 IMP 11313459 negative regulation of cellular senescence GO:2000773 IMP 10449030 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240",tRNA binding 21937513 GO:0000049 IDA transcription coactivator binding 19571879 GO:0001223 IPI DNA binding 21937513 GO:0003677 IDA telomerase activity 12135483 16043710 21531765 GO:0003720 IDA telomerase activity contributes_to 9443919 16507993 17940095 18082603 GO:0003720 IDA telomerase activity GO:0003720 TAS telomerase RNA reverse transcriptase activity 15632080 17940095 GO:0003721 IDA telomerase RNA reverse transcriptase activity contributes_to 9398860 19701182 GO:0003721 IDA telomerase RNA reverse transcriptase activity contributes_to 11313459 GO:0003721 IMP telomerase RNA reverse transcriptase activity 14991929 GO:0003721 TAS RNA binding 19701182 GO:0003723 IPI RNA-directed DNA polymerase activity 21937513 GO:0003964 IDA RNA-directed RNA polymerase activity contributes_to 19701182 GO:0003968 IDA protein binding 11701125 12377759 12699629 15044100 15381700 15857955 17237767 17940095 18082603 18358808 19179534 19487455 19567472 21119197 21829167 22226966 24550003 25172512 25589350 GO:0005515 IPI nucleotidyltransferase activity 19701182 GO:0016779 IDA telomeric DNA binding 9288757 GO:0042162 TAS protein homodimerization activity 11432839 GO:0042803 IDA metal ion binding GO:0046872 IEA telomerase RNA binding 11432839 GO:0070034 IDA telomerase RNA binding 16507993 17940095 18082603 19701182 20351177 GO:0070034 IPI,HTLV-I infection - Homo sapiens (human) hsa05166,CHEMBL CHEMBL181361,P36897,TGF-beta receptor type I,1.0,PRIMARY,NO,Nc1nc(c2ccccn2)c(s1)c3ccc4ncccc4n3,189,408,"InChI=1S/C16H11N5S/c17-16-21-14(12-4-1-2-8-19-12)15(22-16)13-7-6-10-11(20-13)5-3-9-18-10/h1-9H,(H2,17,21)",NQQBKOGAKSBCSI-UHFFFAOYSA-N,"c(""TGF-beta receptor type I"", ""MAP kinase p38"", ""HEK293"", ""Serine/threonine-protein kinase AKT"", ""Serine/threonine-protein kinase AKT2"", ""Serine/threonine-protein kinase AKT3"", ""G protein-coupled receptor kinase 6"", ""G protein-coupled receptor kinase 7"", ""Serine/threonine-protein kinase MRCK-A"", ""Ribosomal protein S6 kinase alpha 5"", ""Ribosomal protein S6 kinase alpha 4"", ""Ribosomal protein S6 kinase 1"", ""3-phosphoinositide dependent protein kinase-1"", ""cAMP-dependent protein kinase alpha-catalytic subunit"", ""Protein kinase C alpha"", ""Protein kinase C beta"", ""Protein kinase C eta"", ""Protein kinase C gamma"", ""Protein kinase C iota"", ""Protein kinase C theta"", ""Protein kinase C mu"", ""Serine/threonine-protein kinase D2"", ""Protein kinase C nu"", ""cGMP-dependent protein kinase 1 beta"", ""cGMP-dependent protein kinase 2"", ""Serine/threonine-protein kinase PRKX"", ""Rho-associated protein kinase 1"", ""Rho-associated protein kinase 2"", ""Ribosomal protein S6 kinase alpha 1"", ""Ribosomal protein S6 kinase alpha 3"", ""Ribosomal protein S6 kinase alpha 2"", ""Ribosomal protein S6 kinase alpha 6"", ""Serine/threonine-protein kinase Sgk1"", ""Serine/threonine-protein kinase Sgk2"", ""Serine/threonine-protein kinase Sgk3"", ""AMP-activated protein kinase, alpha-1 subunit"", ""NUAK family SNF1-like kinase 1"", ""BR serine/threonine-protein kinase 2"", ""CaM kinase II alpha"", ""CaM kinase II delta"", ""Serine/threonine-protein kinase Chk1"", ""Serine/threonine-protein kinase Chk2"", ""Death-associated protein kinase 1"", ""Serine/threonine-protein kinase DCLK2"", ""MAP kinase-activated protein kinase 2"", ""MAP kinase-activated protein kinase 3"", ""Serine/threonine-protein kinase MARK1"", ""Serine/threonine-protein kinase c-TAK1"", ""MAP/microtubule affinity-regulating kinase 4"", ""Maternal embryonic leucine zipper kinase"", ""MAP kinase-interacting serine/threonine-protein kinase MNK1"", ""MAP kinase signal-integrating kinase 2"", ""Phosphorylase kinase gamma subunit 1"", ""Phosphorylase kinase gamma subunit 2"", ""Serine/threonine-protein kinase PIM1"", ""Serine/threonine-protein kinase PIM3"", ""MAP kinase-activated protein kinase 5"", ""Serine/threonine-protein kinase SIK1"", ""Serine/threonine-protein kinase SIK2"", ""Serine/threonine-protein kinase TBK1"", ""Testis-specific serine/threonine-protein kinase 1"", ""Testis-specific serine/threonine-protein kinase 2"", ""Casein kinase I alpha"", ""Casein kinase I gamma 1"", ""Casein kinase I gamma 2"", ""Casein kinase I isoform gamma-3"", ""Cyclin-dependent kinase 1"", ""Cyclin-dependent kinase 2"", ""Cyclin-dependent kinase 3"", ""Cyclin-dependent kinase 4"", ""Cyclin-dependent kinase 5"", ""Cyclin-dependent kinase 6"", ""Dual specificity protein kinase CLK3"", ""Dual-specificity tyrosine-phosphorylation regulated kinase 1A"", ""Dual specificity tyrosine-phosphorylation-regulated kinase 1B"", ""Dual-specificity tyrosine-phosphorylation regulated kinase 2"", ""Glycogen synthase kinase-3 alpha"", ""Glycogen synthase kinase-3 beta"", ""Homeodomain-interacting protein kinase 1"", ""Homeodomain-interacting protein kinase 4"", ""c-Jun N-terminal kinase 2"", ""MAP kinase ERK2"", ""MAP kinase ERK1"", ""Serine/threonine-protein kinase SRPK3"", ""MAP kinase p38 beta"", ""MAP kinase p38 delta"", ""PI3-kinase p110-alpha subunit"", ""PI3-kinase p110-delta subunit"", ""PI4-kinase beta subunit"", ""Casein kinase II alpha"", ""Inhibitor of nuclear factor kappa B kinase alpha subunit"", ""Inhibitor of nuclear factor kappa B kinase beta subunit"", ""Inhibitor of nuclear factor kappa B kinase epsilon subunit"", ""Serine/threonine-protein kinase Nek1"", ""Serine/threonine-protein kinase NEK2"", ""Serine/threonine-protein kinase NEK6"", ""Serine/threonine-protein kinase NEK7"", ""Serine/threonine-protein kinase NEK9"", ""Serine/threonine-protein kinase PLK1"", ""Dual specificity protein kinase TTK"", ""Serine/threonine-protein kinase Aurora-A"", ""Serine/threonine-protein kinase Aurora-B"", ""Serine/threonine-protein kinase Aurora-C"", ""Serine/threonine-protein kinase 10"", ""Mitogen-activated protein kinase kinase kinase kinase 2"", ""Mitogen-activated protein kinase kinase kinase kinase 4"", ""Dual specificity mitogen-activated protein kinase kinase 1"", ""Misshapen-like kinase 1"", ""Serine/threonine-protein kinase MST1"", ""Serine/threonine-protein kinase MST2"", ""Serine/threonine-protein kinase PAK 1"", ""Serine/threonine-protein kinase PAK 2"", ""Serine/threonine-protein kinase PAK 3"", ""Serine/threonine-protein kinase PAK7"", ""Tyrosine-protein kinase ABL"", ""ALK tyrosine kinase receptor"", ""Tyrosine-protein kinase ABL2"", ""Tyrosine-protein kinase BLK"", ""Tyrosine-protein kinase BRK"", ""Tyrosine-protein kinase BTK"", ""Tyrosine-protein kinase CSK"", ""Discoidin domain-containing receptor 2"", ""Epidermal growth factor receptor erbB1"", ""Ephrin type-A receptor 2"", ""Ephrin type-A receptor 3"", ""Ephrin type-A receptor 4"", ""Ephrin type-B receptor 2"", ""Ephrin type-B receptor 3"", ""Ephrin type-B receptor 4"", ""Receptor protein-tyrosine kinase erbB-2"", ""Receptor protein-tyrosine kinase erbB-4"", ""Tyrosine-protein kinase FER"", ""Tyrosine-protein kinase FES"", ""Fibroblast growth factor receptor 1"", ""Fibroblast growth factor receptor 2"", ""Fibroblast growth factor receptor 3"", ""Tyrosine-protein kinase FGR"", ""Vascular endothelial growth factor receptor 1"", ""Tyrosine-protein kinase receptor FLT3"", ""Vascular endothelial growth factor receptor 3"", ""Macrophage colony stimulating factor receptor"", ""Tyrosine-protein kinase HCK"", ""Insulin-like growth factor I receptor"", ""Insulin receptor"", ""Insulin receptor-related protein"", ""Tyrosine-protein kinase ITK/TSK"", ""Tyrosine-protein kinase JAK1"", ""Vascular endothelial growth factor receptor 2"", ""Stem cell growth factor receptor"", ""Tyrosine-protein kinase LCK"", ""Leukocyte tyrosine kinase receptor"", ""Tyrosine-protein kinase Lyn"", ""Proto-oncogene tyrosine-protein kinase MER"", ""Hepatocyte growth factor receptor"", ""Muscle, skeletal receptor tyrosine protein kinase"", ""Platelet-derived growth factor receptor alpha"", ""Platelet-derived growth factor receptor beta"", ""Tyrosine-protein kinase FRK"", ""Protein tyrosine kinase 2 beta"", ""Tyrosine-protein kinase receptor RET"", ""Macrophage-stimulating protein receptor"", ""Proto-oncogene tyrosine-protein kinase ROS"", ""Tyrosine-protein kinase SRC"", ""Tyrosine-protein kinase TEC"", ""Tyrosine-protein kinase TIE-2"", ""Non-receptor tyrosine-protein kinase TNK1"", ""Tyrosine kinase non-receptor protein 2"", ""Nerve growth factor receptor Trk-A"", ""Neurotrophic tyrosine kinase receptor type 2"", ""NT-3 growth factor receptor"", ""Tyrosine-protein kinase TXK"", ""Tyrosine-protein kinase receptor TYRO3"", ""Tyrosine-protein kinase ZAP-70"", ""Serine/threonine-protein kinase B-raf"", ""Serine/threonine-protein kinase RAF"", ""Leucine-rich repeat serine/threonine-protein kinase 2"", ""Serine/threonine-protein kinase MRCK beta"", ""Pyruvate dehydrogenase kinase isoform 1"", ""AMP-activated protein kinase, alpha-2 subunit"", ""BR serine/threonine-protein kinase 1"", ""CaM kinase I delta"", ""MAP/microtubule affinity-regulating kinase 2"", ""Serine/threonine-protein kinase PIM2"", ""Dual specificity protein kinase CLK2"", ""MAP kinase p38 alpha"", ""MAP kinase p38 gamma"", ""Tyrosine-protein kinase BMX"", ""Fibroblast growth factor receptor 4"", ""Tyrosine-protein kinase JAK2"", ""Tyrosine-protein kinase YES"", ""Interleukin-1 receptor-associated kinase 4"", ""Unchecked"")",7046,TGFR1,R-HSA-162582 Signal Transduction R-HSA-1643685 Disease R-HSA-170834 Signaling by TGF-beta Receptor Complex R-HSA-2173788 Downregulation of TGF-beta receptor signaling R-HSA-2173789 TGF-beta receptor signaling activates SMADs R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-3304349 Loss of Function of SMAD2/3 in Cancer R-HSA-3304351 Signaling by TGF-beta Receptor Complex in Cancer R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3315487 SMAD2/3 MH2 Domain Mutants in Cancer R-HSA-3642278 Loss of Function of TGFBR2 in Cancer R-HSA-3645790 TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3656532 TGFBR1 KD Mutants in Cancer R-HSA-3656534 Loss of Function of TGFBR1 in Cancer R-HSA-5663202 Diseases of signal transduction,GO:0005768 endosome IEA GO:0005886 plasma membrane 17878231 25893292 IDA GO:0005886 plasma membrane TAS GO:0005923 bicellular tight junction 15761148 IDA GO:0009986 cell surface 25893292 IDA GO:0043235 receptor complex 8774881 14517293 IDA GO:0045121 membrane raft 25893292 IDA GO:0070022 transforming growth factor beta receptor homodimeric complex 1326540 IC,"18625725 IDA GO:0000186 activation of MAPKK activity ISS GO:0001501 skeletal system development IEA GO:0001525 angiogenesis ISS GO:0001701 in utero embryonic development ISS GO:0001822 kidney development IEA GO:0001824 blastocyst development 15761148 IDA GO:0001837 epithelial to mesenchymal transition IEA GO:0001937 negative regulation of endothelial cell proliferation ISS GO:0001938 positive regulation of endothelial cell proliferation IEA GO:0002088 lens development in camera-type eye 14517293 IDA GO:0006355 regulation of transcription, DNA-templated 15702480 IMP GO:0006355 regulation of transcription, DNA-templated 12015308 12065756 IDA GO:0006468 protein phosphorylation IEA GO:0006915 apoptotic process 9759503 TAS GO:0007050 cell cycle arrest 14633705 IDA GO:0007165 signal transduction 1326540 IC GO:0007179 transforming growth factor beta receptor signaling pathway 9389648 11157754 IDA GO:0007179 transforming growth factor beta receptor signaling pathway 1333888 IMP GO:0007179 transforming growth factor beta receptor signaling pathway TAS GO:0007179 transforming growth factor beta receptor signaling pathway ISS GO:0007507 heart development 14633705 IMP GO:0008284 positive regulation of cell proliferation ISS GO:0008354 germ cell migration IEA GO:0008584 male gonad development IEA GO:0009791 post-embryonic development ISS GO:0009952 anterior/posterior pattern specification ISS GO:0010717 regulation of epithelial to mesenchymal transition 9311995 9389648 IDA GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 15761148 IDA GO:0018105 peptidyl-serine phosphorylation 19736306 IDA GO:0018107 peptidyl-threonine phosphorylation IEA GO:0023014 signal transduction by protein phosphorylation ISS GO:0030199 collagen fibril organization 18625725 IDA GO:0030307 positive regulation of cell growth 19736306 IDA GO:0030335 positive regulation of cell migration TAS GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 18758450 IDA GO:0031396 regulation of protein ubiquitination ISS GO:0032331 negative regulation of chondrocyte differentiation ISS GO:0032924 activin receptor signaling pathway ISS GO:0035556 intracellular signal transduction 9759503 TAS GO:0042060 wound healing ISS GO:0042118 endothelial cell activation 9759503 TAS GO:0043062 extracellular structure organization IEA GO:0043393 regulation of protein binding IEA GO:0043542 endothelial cell migration 9311995 9389648 IDA GO:0045893 positive regulation of transcription, DNA-templated ISS GO:0048538 thymus development ISS GO:0048663 neuron fate commitment ISS GO:0048701 embryonic cranial skeleton morphogenesis ISS GO:0048705 skeletal system morphogenesis 9759503 TAS GO:0048762 mesenchymal cell differentiation ISS GO:0048844 artery morphogenesis 18625725 IMP GO:0048870 cell motility 18625725 IMP GO:0051272 positive regulation of cellular component movement IEA GO:0051491 positive regulation of filopodium assembly 18625725 IDA GO:0051897 positive regulation of protein kinase B signaling ISS GO:0060017 parathyroid gland development ISS GO:0060021 palate development ISS GO:0060037 pharyngeal system development ISS GO:0060317 cardiac epithelial to mesenchymal transition 11157754 12015308 18625725 19736306 IDA GO:0060389 pathway-restricted SMAD protein phosphorylation 9389648 IDA GO:0060391 positive regulation of SMAD protein import into nucleus 17878231 IDA GO:0070723 response to cholesterol 19494318 IDA GO:0071560 cellular response to transforming growth factor beta stimulus 18758450 IDA GO:2001235 positive regulation of apoptotic signaling pathway 18625725 IMP GO:2001237 negative regulation of extrinsic apoptotic signaling pathway","19736306 GO:0004672 protein kinase activity IDA 12065756 18625725 GO:0004674 protein serine/threonine kinase activity IDA GO:0004702 receptor signaling protein serine/threonine kinase activity IEA 1326540 GO:0005024 transforming growth factor beta-activated receptor activity IC 12015308 14633705 GO:0005024 transforming growth factor beta-activated receptor activity IDA 18625725 GO:0005024 transforming growth factor beta-activated receptor activity IMP 1333888 GO:0005024 transforming growth factor beta-activated receptor activity IMP contributes_to 8752209 GO:0005025 transforming growth factor beta receptor activity, type I IDA GO:0005057 receptor signaling protein activity ISS 11157754 GO:0005114 type II transforming growth factor beta receptor binding IDA 1333888 GO:0005114 type II transforming growth factor beta receptor binding IPI 8622651 10025408 11278302 11279102 12015308 14517293 14580334 15702480 15761148 17099224 18243111 18625725 18758450 18974388 19732720 20856203 22344298 24263861 24658140 25893292 GO:0005515 protein binding IPI 12065756 GO:0005524 ATP binding IDA 14517293 GO:0019838 growth factor binding IPI contributes_to 12065756 18625725 GO:0046332 SMAD binding IDA 8980228 9311995 GO:0046332 SMAD binding IPI GO:0046872 metal ion binding IEA 11157754 14633705 GO:0050431 transforming growth factor beta binding IDA 1333888 GO:0050431 transforming growth factor beta binding IMP contributes_to 1326540 GO:0050431 transforming growth factor beta binding IPI 11278251 GO:0070411 I-SMAD binding IPI",hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) hsa04068 FoxO signaling pathway - Homo sapiens (human) hsa04144 Endocytosis - Homo sapiens (human) hsa04350 TGF-beta signaling pathway - Homo sapiens (human) hsa04380 Osteoclast differentiation - Homo sapiens (human) hsa04390 Hippo signaling pathway - Homo sapiens (human) hsa04520 Adherens junction - Homo sapiens (human) hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05161 Hepatitis B - Homo sapiens (human) hsa05166 HTLV-I infection - Homo sapiens (human) hsa05200 Pathways in cancer - Homo sapiens (human) hsa05210 Colorectal cancer - Homo sapiens (human) hsa05212 Pancreatic cancer - Homo sapiens (human) hsa05220 Chronic myeloid leukemia - Homo sapiens (human),CHEMBL CHEMBL25889,P04818,Thymidylate synthase,1.0,PRIMARY,NO,Cc1nc(O)c2cc(CN(CC#C)c3ccc(cc3)C(=O)NC(CCC(=O)O)C(=O)O)ccc2n1,5,27,"InChI=1S/C25H24N4O6/c1-3-12-29(14-16-4-9-20-19(13-16)24(33)27-15(2)26-20)18-7-5-17(6-8-18)23(32)28-21(25(34)35)10-11-22(30)31/h1,4-9,13,21H,10-12,14H2,2H3,(H,28,32)(H,30,31)(H,34,35)(H,26,27,33)",PMTUUSDTAKQWQJ-UHFFFAOYSA-N,"c(""Thymidylate synthase"", ""CCRF-CEM"", ""GC3/M"", ""GC3/MTK-"", ""SW480"", ""MCF7"", ""Manca"", ""MOLT-4"", ""Folylpoly-gamma-glutamate synthetase"", ""Unchecked"", ""Dihydrofolate reductase"", ""GAR transformylase"", ""AICAR transformylase"", ""Lymphoma cell line"")",7298,TYSY,Metabolism R-HSA-1430728 Metabolism of nucleotides R-HSA-15869 Pyrimidine biosynthesis R-HSA-500753 Pyrimidine metabolism R-HSA-73848,nucleus GO:0005634 IDA 21876188 nucleoplasm GO:0005654 TAS nucleolus GO:0005730 IEA cytoplasm GO:0005737 IDA 21876188 mitochondrion GO:0005739 IDA 21876188 mitochondrial inner membrane GO:0005743 IDA 21876188 mitochondrial matrix GO:0005759 IDA 21876188 cytosol GO:0005829 TAS,G1/S transition of mitotic cell cycle GO:0000082 TAS regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083 TAS nucleobase-containing compound metabolic process GO:0006139 2987839 TAS dTMP biosynthetic process GO:0006231 15093541 IDA dTTP biosynthetic process GO:0006235 IEA aging GO:0007568 IEA circadian rhythm GO:0007623 IEA cell proliferation GO:0008283 15093541 NAS deoxyribonucleoside monophosphate biosynthetic process GO:0009157 2987839 TAS response to toxic substance GO:0009636 IEA cell growth GO:0016049 15093541 NAS immortalization of host cell by virus GO:0019088 IEA uracil metabolic process GO:0019860 IEA organ regeneration GO:0031100 IEA methylation GO:0032259 IEA response to progesterone GO:0032570 IEA response to vitamin A GO:0033189 IEA response to cytokine GO:0034097 IEA tetrahydrofolate interconversion GO:0035999 15093541 IDA response to drug GO:0042493 IEA response to ethanol GO:0045471 IEA dUMP metabolic process GO:0046078 IEA pyrimidine nucleoside biosynthetic process GO:0046134 TAS response to organophosphorus GO:0046683 16079077 IEP developmental growth GO:0048589 IEA cartilage development GO:0051216 IEA response to glucocorticoid GO:0051384 IEA response to folic acid GO:0051593 IEA intestinal epithelial cell maturation GO:0060574 IEA DNA biosynthetic process GO:0071897 15093541 IC,nucleotide binding IEA GO:0000166 mRNA binding IEA GO:0003729 thymidylate synthase activity IDA 15093541 GO:0004799 thymidylate synthase activity TAS GO:0004799 folic acid binding IC 15093541 GO:0005542 drug binding IEA GO:0008144 protein homodimerization activity IEA GO:0042803 cofactor binding IEA GO:0048037,Pyrimidine metabolism - Homo sapiens (human) hsa00240 One carbon pool by folate - Homo sapiens (human) hsa00670,CHEMBL CHEMBL125946,P10828,Thyroid hormone receptor beta-1,1.0,PRIMARY,NO,Oc1ccc(Oc2c(Cl)cc(cc2Cl)N3N=CC(=O)NC3=O)cc1S(=O)(=O)N4C5CCC4CC6(CCCO6)C5,2,5,"InChI=1S/C25H24Cl2N4O7S/c26-18-8-16(30-24(34)29-22(33)13-28-30)9-19(27)23(18)38-17-4-5-20(32)21(10-17)39(35,36)31-14-2-3-15(31)12-25(11-14)6-1-7-37-25/h4-5,8-10,13-15,32H,1-3,6-7,11-12H2,(H,29,33,34)",JHJHCOACTCIKNP-UHFFFAOYSA-N,"c(""Thyroid hormone receptor beta-1"", ""Thyroid hormone receptor"", ""Thyroid hormone receptor alpha"")",7068,THB,R-HSA-212436 Generic Transcription Pathway R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-74160 Gene Expression,IEA GO:0000790 nuclear chromatin IDA GO:0005634 nucleus TAS GO:0005654 nucleoplasm 23376485 IDA GO:0070062 extracellular exosome,"negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA transcription, DNA-templated 1618799 GO:0006351 TAS transcription initiation from RNA polymerase II promoter GO:0006367 TAS sensory perception of sound GO:0007605 IEA negative regulation of female receptivity GO:0007621 IEA regulation of heart contraction GO:0008016 IEA female courtship behavior GO:0008050 IEA organ morphogenesis GO:0009887 IEA intracellular receptor signaling pathway GO:0030522 IEA steroid hormone mediated signaling pathway GO:0043401 IEA positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA Type I pneumocyte differentiation GO:0060509 IEA","DNA binding GO:0003677 TAS 1618799 transcription factor activity, sequence-specific DNA binding GO:0003700 NAS 1618799 steroid hormone receptor activity GO:0003707 IEA transcription corepressor activity GO:0003714 TAS 1618799 thyroid hormone receptor activity GO:0004887 IDA 15466465 protein binding GO:0005515 IPI 7870181 15100213 15625236 zinc ion binding GO:0008270 IEA enzyme binding GO:0019899 IPI 12039952 chromatin DNA binding GO:0031490 IEA sequence-specific DNA binding GO:0043565 IEA thyroid hormone binding GO:0070324 IDA 15466465",hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human),CHEMBL CHEMBL3398488,Q9NYK1,Toll-like receptor 7,1.0,PRIMARY,NO,Cl.CCCCOc1nc(N)c2NC(=O)N(CCCCCC3CCNCC3)c2n1,2,3,"InChI=1S/C19H32N6O2.ClH/c1-2-3-13-27-18-23-16(20)15-17(24-18)25(19(26)22-15)12-6-4-5-7-14-8-10-21-11-9-14;/h14,21H,2-13H2,1H3,(H,22,26)(H2,20,23,24);1H",JAXMUSKZAMULNG-UHFFFAOYSA-N,"c(""Toll-like receptor 8"", ""Unchecked"", ""Toll-like receptor 7"")",51284,TLR7,Trafficking and processing of endosomal TLR R-HSA-1679131 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Toll-Like Receptors Cascades R-HSA-168898 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 MyD88 dependent cascade initiated on endosome R-HSA-975155,Golgi membrane GO:0000139 TAS cytoplasm GO:0005737 19740627 IDA lysosome GO:0005764 ISS endosome GO:0005768 ISS endoplasmic reticulum GO:0005783 ISS endoplasmic reticulum membrane GO:0005789 TAS plasma membrane GO:0005886 19740627 IDA integral component of plasma membrane GO:0005887 IBA endosome membrane GO:0010008 TAS early phagosome GO:0032009 ISS endolysosome membrane GO:0036020 TAS receptor complex GO:0043235 23382219 IDA,GO:0001774 microglial cell activation IEA GO:0001932 regulation of protein phosphorylation IEA GO:0002224 toll-like receptor signaling pathway TAS GO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA GO:0006954 inflammatory response IBA 19740627 GO:0007252 I-kappaB phosphorylation IDA 19740627 GO:0032722 positive regulation of chemokine production IDA GO:0032755 positive regulation of interleukin-6 production IEA 19740627 GO:0032757 positive regulation of interleukin-8 production IDA GO:0034154 toll-like receptor 7 signaling pathway IBA GO:0034162 toll-like receptor 9 signaling pathway TAS 19740627 GO:0042346 positive regulation of NF-kappaB import into nucleus IDA 16286015 GO:0045078 positive regulation of interferon-gamma biosynthetic process IDA GO:0045087 innate immune response IEA 16286015 GO:0045356 positive regulation of interferon-alpha biosynthetic process IDA 16286015 GO:0045359 positive regulation of interferon-beta biosynthetic process IDA 16188996 GO:0045416 positive regulation of interleukin-8 biosynthetic process IMP 19740627 GO:0050729 positive regulation of inflammatory response IC 16188996 GO:0051607 defense response to virus IMP 19593445 GO:0071260 cellular response to mechanical stimulus IEP,IDA 16111635 double-stranded RNA binding GO:0003725 IBA GO:0003727 single-stranded RNA binding ISS GO:0003727 single-stranded RNA binding IBA GO:0004872 receptor activity IEA GO:0004888 transmembrane signaling receptor activity IEA GO:0008144 drug binding ISS GO:0035197 siRNA binding,hsa04620 Toll-like receptor signaling pathway - Homo sapiens (human) hsa05162 Measles - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human),CHEMBL CHEMBL3357070,Q9NR96,Toll-like receptor 9,1.0,PRIMARY,NO,OCCN1CCN(CC1)c2ccc(cc2)c3ncc4CCN(CCCN5CCOCC5)c4n3,3,6,"InChI=1S/C25H36N6O2/c32-17-14-29-10-12-30(13-11-29)23-4-2-21(3-5-23)24-26-20-22-6-9-31(25(22)27-24)8-1-7-28-15-18-33-19-16-28/h2-5,20,32H,1,6-19H2",VQQGQCSLCPMKAG-UHFFFAOYSA-N,"c(""PBMC"", ""Unchecked"", ""Toll-like receptor 8"", ""Toll-like receptor 7"", ""Toll-like receptor 9"")",54106,TLR9,PI3K Cascade R-HSA-109704 IRS-mediated signalling R-HSA-112399 Signal Transduction R-HSA-162582 Trafficking and processing of endosomal TLR R-HSA-1679131 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168138 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168181 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Toll-Like Receptors Cascades R-HSA-168898 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975110 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975138 MyD88 dependent cascade initiated on endosome R-HSA-975155,GO:0000139 Golgi membrane TAS 11130078 GO:0005576 extracellular region NAS 19740627 GO:0005737 cytoplasm IDA GO:0005764 lysosome ISS GO:0005768 endosome ISS GO:0005783 endoplasmic reticulum ISS GO:0005789 endoplasmic reticulum membrane TAS 19740627 GO:0005886 plasma membrane IDA GO:0010008 endosome membrane TAS GO:0016021 integral component of membrane IEA 17128265 GO:0016323 basolateral plasma membrane IDA 17128265 GO:0016324 apical plasma membrane IDA GO:0032009 early phagosome ISS GO:0036020 endolysosome membrane TAS,toll-like receptor signaling pathway TAS GO:0002224 response to molecule of bacterial origin TAS 15356140 GO:0002237 MyD88-dependent toll-like receptor signaling pathway IEA GO:0002755 inflammatory response IEA GO:0006954 I-kappaB phosphorylation IDA 19740627 GO:0007252 NOT axonogenesis IBA GO:0007409 positive regulation of gene expression IDA 24409285 GO:0010628 maintenance of gastrointestinal epithelium ISS GO:0030277 negative regulation of NF-kappaB transcription factor activity IDA 17128265 GO:0032088 tumor necrosis factor production IDA 23826189 GO:0032640 negative regulation of interleukin-6 production ISS GO:0032715 negative regulation of interleukin-8 production IDA 17128265 GO:0032717 positive regulation of chemokine production IDA 19740627 GO:0032722 positive regulation of granulocyte macrophage colony-stimulating factor production IDA 24409285 GO:0032725 positive regulation of interferon-beta production ISS GO:0032728 positive regulation of interleukin-10 production ISS GO:0032733 positive regulation of interleukin-12 production ISS GO:0032735 positive regulation of interleukin-18 production ISS GO:0032741 positive regulation of interleukin-6 production IDA 19740627 24409285 GO:0032755 positive regulation of interleukin-8 production IDA 17128265 19740627 24409285 GO:0032757 positive regulation of tumor necrosis factor production ISS GO:0032760 negative regulation of toll-like receptor signaling pathway IDA 17128265 GO:0034122 positive regulation of toll-like receptor signaling pathway IDA 17128265 GO:0034123 toll-like receptor 9 signaling pathway TAS GO:0034162 phosphatidylinositol-3-phosphate biosynthetic process IEA GO:0036092 positive regulation of NF-kappaB import into nucleus IDA 19740627 GO:0042346 defense response to bacterium NAS 11130078 GO:0042742 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA 17128265 GO:0043123 positive regulation of JUN kinase activity IDA 17128265 GO:0043507 positive regulation of interferon-gamma biosynthetic process IDA 16286015 GO:0045078 innate immune response TAS 15356140 GO:0045087 positive regulation of interferon-alpha biosynthetic process IDA 16286015 GO:0045356 positive regulation of interferon-beta biosynthetic process IDA 16286015 GO:0045359 positive regulation of transcription from RNA polymerase II promoter ISS GO:0045944 positive regulation of JNK cascade IC 17128265 GO:0046330 regulation of cytokine secretion IEA GO:0050707 positive regulation of inflammatory response IC 19740627 GO:0050729 defense response to Gram-negative bacterium IMP 22427638 GO:0050829 positive regulation of NF-kappaB transcription factor activity IDA 17128265 GO:0051092 positive regulation of nitric-oxide synthase biosynthetic process ISS GO:0051770 negative regulation of calcium-transporting ATPase activity IDA 24610369 GO:1901895,transmembrane signaling receptor activity GO:0004888 IEA interleukin-1 receptor binding GO:0005149 12925853 IPI 1-phosphatidylinositol-3-kinase activity GO:0016303 TAS siRNA binding GO:0035197 15723075 IMP,Toll-like receptor signaling pathway - Homo sapiens (human) hsa04620 Chagas disease (American trypanosomiasis) - Homo sapiens (human) hsa05142 African trypanosomiasis - Homo sapiens (human) hsa05143 Malaria - Homo sapiens (human) hsa05144 Tuberculosis - Homo sapiens (human) hsa05152 Measles - Homo sapiens (human) hsa05162 Herpes simplex infection - Homo sapiens (human) hsa05168,CHEMBL CHEMBL3299022,O75762,Transient receptor potential cation channel subfamily A member 1,1.0,ORTHOGONAL,NO,FC(F)(F)c1ccccc1c2cc3cn[nH]c3cc2OCC4CC4,4,7,"InChI=1S/C18H15F3N2O/c19-18(20,21)15-4-2-1-3-13(15)14-7-12-9-22-23-16(12)8-17(14)24-10-11-5-6-11/h1-4,7-9,11H,5-6,10H2,(H,22,23)",BZTMKWCWKFEAKS-UHFFFAOYSA-N,"c(""Transient receptor potential cation channel subfamily A member 1"", ""Vanilloid receptor"", ""Transient receptor potential cation channel subfamily V member 3"", ""Transient receptor potential cation channel subfamily M member 8"", ""Unchecked"")",8989,TRPA1,R-HSA-2672351 Stimuli-sensing channels R-HSA-3295583 TRP channels R-HSA-382551 Transmembrane transport of small molecules R-HSA-983712 Ion channel transport,intracellular IEA GO:0005622 plasma membrane TAS GO:0005886 integral component of plasma membrane IMP 20547126 25855297 GO:0005887 stereocilium bundle IEA GO:0032421,GO:0006811 ion transport 10066796 TAS GO:0007166 cell surface receptor signaling pathway IEA GO:0009409 response to cold IEA GO:0010033 response to organic substance 20547126 IMP GO:0014070 response to organic cyclic compound IEA GO:0019233 sensory perception of pain 20547126 IMP GO:0042493 response to drug IEA GO:0042542 response to hydrogen peroxide IEA GO:0048265 response to pain IEA GO:0050955 thermoception IEA GO:0050966 detection of mechanical stimulus involved in sensory perception of pain IEA GO:0050968 detection of chemical stimulus involved in sensory perception of pain IEA GO:0051209 release of sequestered calcium ion into cytosol IEA GO:0051289 protein homotetramerization 25855297 IDA GO:0070588 calcium ion transmembrane transport 20547126 25855297 IMP GO:0070588 calcium ion transmembrane transport TAS,calcium channel activity GO:0005262 TAS channel activity 10066796 GO:0015267 TAS calcium-release channel activity 20547126 GO:0015278 IDA calcium-release channel activity 25855297 GO:0015278 IMP temperature-gated cation channel activity 20547126 GO:0097604 IDA,hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human),CHEMBL CHEMBL3298923,O75762,Transient receptor potential cation channel subfamily A member 1,1.0,PRIMARY,NO,Cc1cc2[nH]ncc2cc1c3ccccc3C(F)(F)F,4,9,"InChI=1S/C15H11F3N2/c1-9-6-14-10(8-19-20-14)7-12(9)11-4-2-3-5-13(11)15(16,17)18/h2-8H,1H3,(H,19,20)",NXFIEIXVSJMOQL-UHFFFAOYSA-N,"c(""Transient receptor potential cation channel subfamily A member 1"", ""Vanilloid receptor"", ""Transient receptor potential cation channel subfamily V member 3"", ""Transient receptor potential cation channel subfamily M member 8"", ""Unchecked"")",8989,TRPA1,R-HSA-2672351 Stimuli-sensing channels R-HSA-3295583 TRP channels R-HSA-382551 Transmembrane transport of small molecules R-HSA-983712 Ion channel transport,intracellular IEA GO:0005622 plasma membrane TAS GO:0005886 integral component of plasma membrane IMP 20547126 25855297 GO:0005887 stereocilium bundle IEA GO:0032421,GO:0006811 ion transport 10066796 TAS GO:0007166 cell surface receptor signaling pathway IEA GO:0009409 response to cold IEA GO:0010033 response to organic substance 20547126 IMP GO:0014070 response to organic cyclic compound IEA GO:0019233 sensory perception of pain 20547126 IMP GO:0042493 response to drug IEA GO:0042542 response to hydrogen peroxide IEA GO:0048265 response to pain IEA GO:0050955 thermoception IEA GO:0050966 detection of mechanical stimulus involved in sensory perception of pain IEA GO:0050968 detection of chemical stimulus involved in sensory perception of pain IEA GO:0051209 release of sequestered calcium ion into cytosol IEA GO:0051289 protein homotetramerization 25855297 IDA GO:0070588 calcium ion transmembrane transport 20547126 25855297 IMP GO:0070588 calcium ion transmembrane transport TAS,calcium channel activity GO:0005262 TAS channel activity 10066796 GO:0015267 TAS calcium-release channel activity 20547126 GO:0015278 IDA calcium-release channel activity 25855297 GO:0015278 IMP temperature-gated cation channel activity 20547126 GO:0097604 IDA,hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human),CHEMBL CHEMBL3353597,Q7Z2W7,Transient receptor potential cation channel subfamily M member 8,1.0,ORTHOGONAL,NO,OC(=O)c1ccc(cc1)S(=O)(=O)N(Cc2ccc(OC(F)(F)F)cc2)c3ncc(cc3Cl)C(F)(F)F,3,4,"InChI=1S/C21H13ClF6N2O5S/c22-17-9-14(20(23,24)25)10-29-18(17)30(11-12-1-5-15(6-2-12)35-21(26,27)28)36(33,34)16-7-3-13(4-8-16)19(31)32/h1-10H,11H2,(H,31,32)",IJGQFZYYEHCCIZ-UHFFFAOYSA-N,"c(""Transient receptor potential cation channel subfamily M member 8"", ""Transient receptor potential cation channel subfamily A member 1"", ""Transient receptor potential cation channel subfamily V member 4"")",79054,TRPM8,Stimuli-sensing channels R-HSA-2672351 TRP channels R-HSA-3295583 Transmembrane transport of small molecules R-HSA-382551 Ion channel transport R-HSA-983712,endoplasmic reticulum membrane GO:0005789 IEA plasma membrane GO:0005886 IDA 25559186 plasma membrane GO:0005886 TAS external side of plasma membrane GO:0009897 IEA integral component of membrane GO:0016021 IEA membrane raft GO:0045121 IEA,IEA GO:0006874 cellular calcium ion homeostasis IEA GO:0009409 response to cold IEA GO:0016048 detection of temperature stimulus IEA GO:0050955 thermoception IEA GO:0051289 protein homotetramerization IEA GO:0070207 protein homotrimerization TAS GO:0070588 calcium ion transmembrane transport,GO:0005262 calcium channel activity TAS 25559186 GO:0005515 protein binding IPI GO:0042803 protein homodimerization activity IEA,Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04750,CHEMBL CHEMBL2443061,Q7Z2W7,Transient receptor potential cation channel subfamily M member 8,1.0,PRIMARY,NO,O[C@@H]1CC2(CCN(CC2)C(=O)Nc3ccc(OC(F)(F)F)cc3)Oc4c(Cl)cccc14,5,5,"InChI=1S/C21H20ClF3N2O4/c22-16-3-1-2-15-17(28)12-20(31-18(15)16)8-10-27(11-9-20)19(29)26-13-4-6-14(7-5-13)30-21(23,24)25/h1-7,17,28H,8-12H2,(H,26,29)/t17-/m1/s1",UQEATFAWAKBMKD-QGZVFWFLSA-N,"c(""Transient receptor potential cation channel subfamily A member 1"", ""Transient receptor potential cation channel subfamily V member 4"", ""Transient receptor potential cation channel subfamily V member 3"", ""Vanilloid receptor"", ""Transient receptor potential cation channel subfamily M member 8"")",79054,TRPM8,Stimuli-sensing channels R-HSA-2672351 TRP channels R-HSA-3295583 Transmembrane transport of small molecules R-HSA-382551 Ion channel transport R-HSA-983712,endoplasmic reticulum membrane GO:0005789 IEA plasma membrane GO:0005886 IDA 25559186 plasma membrane GO:0005886 TAS external side of plasma membrane GO:0009897 IEA integral component of membrane GO:0016021 IEA membrane raft GO:0045121 IEA,IEA GO:0006874 cellular calcium ion homeostasis IEA GO:0009409 response to cold IEA GO:0016048 detection of temperature stimulus IEA GO:0050955 thermoception IEA GO:0051289 protein homotetramerization IEA GO:0070207 protein homotrimerization TAS GO:0070588 calcium ion transmembrane transport,GO:0005262 calcium channel activity TAS 25559186 GO:0005515 protein binding IPI GO:0042803 protein homodimerization activity IEA,Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04750,CHEMBL CHEMBL1081262,P55072,Transitional endoplasmic reticulum ATPase,1.0,PRIMARY,NO,Oc1ccc(Nc2nc(cs2)c3cccs3)cc1,2,16,"InChI=1S/C13H10N2OS2/c16-10-5-3-9(4-6-10)14-13-15-11(8-18-13)12-2-1-7-17-12/h1-8,16H,(H,14,15)",CYHUWUQCNGKSKF-UHFFFAOYSA-N,"c(""Transitional endoplasmic reticulum ATPase"", ""Unchecked"", ""Microtubule-associated protein tau"", ""Aldehyde dehydrogenase 1A1"", ""Menin/Histone-lysine N-methyltransferase MLL"", ""Histone-lysine N-methyltransferase, H3 lysine-9 specific 3"", ""HepG2"", ""Geminin"", ""Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1"")",7415,TERA,"Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template R-HSA-110313 Translesion Synthesis by POLH R-HSA-110320 Signal Transduction R-HSA-162582 Disease R-HSA-1643685 Cellular responses to stress R-HSA-2262752 HSF1 activation R-HSA-3371511 Cellular response to heat stress R-HSA-3371556 Hedgehog ligand biogenesis R-HSA-5358346 Signaling by Hedgehog R-HSA-5358351 Hh mutants that don,t undergo autocatalytic processing are degraded by ERAD R-HSA-5362768 Hh mutants abrogate ligand secretion R-HSA-5387390 Diseases of signal transduction R-HSA-5663202 DNA Damage Bypass R-HSA-73893 DNA Repair R-HSA-73894",IDA 9452483 proteasome complex GO:0000502 IDA 10855792 21630459 nucleus GO:0005634 TAS 16130169 nucleus GO:0005634 IDA GO:0005654 nucleoplasm TAS GO:0005654 nucleoplasm IDA GO:0005737 cytoplasm IDA 15215856 24089527 endoplasmic reticulum GO:0005783 IDA 17872946 endoplasmic reticulum membrane GO:0005789 IDA 23297223 lipid particle GO:0005811 IDA 10855792 15215856 cytosol GO:0005829 TAS 16186510 cytosol GO:0005829 ISS GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex TAS 16186510 VCP-NPL4-UFD1 AAA ATPase complex GO:0034098 IDA 22120668 site of double-strand break GO:0035861 IDA 15215856 17872946 Derlin-1 retrotranslocation complex GO:0036513 IEA GO:0043209 myelin sheath ISS GO:0043231 intracellular membrane-bounded organelle IDA 16275660 perinuclear region of cytoplasm GO:0048471 IDA 19056867 20458337 23376485 23533145 extracellular exosome GO:0070062 ISS GO:1990730 VCP-NSFL1C complex,"16140914 NAS GO:0006281 DNA repair 10855792 22120668 IDA GO:0006302 double-strand break repair 23498975 IMP GO:0006734 NADH metabolic process IEA GO:0006888 ER to Golgi vesicle-mediated transport ISS GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 16140914 22120668 23042605 IDA GO:0006974 cellular response to DNA damage stimulus 23498975 IMP GO:0010918 positive regulation of mitochondrial membrane potential 22120668 IDA GO:0016567 protein ubiquitination 15215856 NAS GO:0016567 protein ubiquitination 22607976 IMP GO:0018279 protein N-linked glycosylation via asparagine 22379090 IMP GO:0019079 viral genome replication 23042605 IMP GO:0019985 translesion synthesis 17872946 IDA GO:0030433 ER-associated ubiquitin-dependent protein catabolic process 22607976 IMP GO:0030433 ER-associated ubiquitin-dependent protein catabolic process 15215856 TAS GO:0030433 ER-associated ubiquitin-dependent protein catabolic process 15215856 TAS GO:0030968 endoplasmic reticulum unfolded protein response 15215856 IDA GO:0030970 retrograde protein transport, ER to cytosol 25660456 IMP GO:0030970 retrograde protein transport, ER to cytosol 18775313 IDA GO:0031334 positive regulation of protein complex assembly 9452483 IDA GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA GO:0034214 protein hexamerization 25088257 IDA GO:0036503 ERAD pathway 16130169 TAS GO:0042981 regulation of apoptotic process 15743842 NAS GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 15215856 TAS GO:0045184 establishment of protein localization 11483959 18775313 IDA GO:0045732 positive regulation of protein catabolic process IEA GO:0046034 ATP metabolic process IEA GO:0051260 protein homooligomerization IEA GO:0070842 aggresome assembly TAS GO:0070987 error-free translesion synthesis 24089527 IMP GO:0071712 ER-associated misfolded protein catabolic process 23498975 IMP GO:0072389 flavin adenine dinucleotide catabolic process 22970133 IDA GO:1903006 positive regulation of protein K63-linked deubiquitination 22970133 IDA GO:1903007 positive regulation of Lys63-specific deubiquitinase activity 23498975 IMP GO:1903715 regulation of aerobic respiration 23498975 IMP GO:1903862 positive regulation of oxidative phosphorylation 23498975 IMP GO:2001171 positive regulation of ATP biosynthetic process",protein binding IPI 9452483 10364224 10855792 15161933 15215856 15743842 16186510 16275660 16449189 16525503 17314412 17525332 17681147 17872946 18654987 18656546 18775313 19818707 19822669 20414249 21135095 21343306 21900206 21949850 21988832 22120668 22795130 22902628 22948820 23042605 23042607 24089527 25814554 26496610 GO:0005515 ATP binding IEA GO:0005524 lipid binding IEA GO:0008289 ATPase activity TAS 15215856 GO:0016887 protein phosphatase binding IPI 10364224 GO:0019903 protein domain specific binding IPI 15362974 GO:0019904 polyubiquitin binding IDA 11483959 GO:0031593 ubiquitin protein ligase binding IPI 22590560 GO:0031625 deubiquitinase activator activity IDA 22970133 GO:0035800 K48-linked polyubiquitin binding IEA GO:0036435 MHC class I protein binding IEA GO:0042288 identical protein binding IEA GO:0042802 ADP binding IEA GO:0043531 ubiquitin-like protein ligase binding IPI 16186510 GO:0044389 poly(A) RNA binding IDA 22681889 GO:0044822 BAT3 complex binding IPI 21636303 GO:1904288 ubiquitin-specific protease binding IPI 22590560 22970133 GO:1990381,Protein processing in endoplasmic reticulum - Homo sapiens (human) hsa04141 Legionellosis - Homo sapiens (human) hsa05134,CHEMBL CHEMBL428647,Q13509,Tubulin beta-3 chain,1.0,PRIMARY,NO,CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(=O)C)[C@H]2[C@H](OC(=O)c4ccccc4)[C@]5(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c6ccccc6)c7ccccc7)C(=C1C5(C)C)C,14,3002,"InChI=1S/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)49)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37+,38-,40-,45+,46-,47+/m0/s1",RCINICONZNJXQF-MZXODVADSA-N,"c(""Tubulin beta-1 chain"", ""SK-OV-3"", ""MCF7"", ""A549"", ""HCT-116"", ""Unchecked"", ""Homo sapiens"", ""HL-60"", ""DU-145"", ""NCI-H460"", ""HT-29"", ""MES-SA/DxS"", ""EVSA-T"", ""WiDr"", ""IGROV-1"", ""M19-MEL"", ""A498"", ""NCI-H226"", ""ADMET"", ""CCD 19Lu"", ""Lu-99 cell line"", ""CCRF-CEM"", ""NSCLC"", ""Lewis lung carcinoma cell line"", ""PC-6"", ""MDA-MB-435"", ""MCF7S"", ""MCF7R"", ""KB"", ""SF-268"", ""RKO"", ""LT12 tumor cell line"", ""K562"", ""PG-49 cell line"", ""A121"", ""BeWo"", ""A2780"", ""MOLT-4"", ""SR"", ""HOP-62"", ""NCI-H522"", ""COLO 205"", ""HCC 2998"", ""HCT-15"", ""KM12"", ""SF-295"", ""SF-539"", ""SNB-19"", ""U-251"", ""PC-3"", ""M14"", ""SK-MEL-2"", ""SK-MEL-5"", ""UACC-62"", ""OVCAR-3"", ""OVCAR-8"", ""786-0"", ""RXF 393"", ""UO-31"", ""NCI/ADR-RES"", ""Hs-578T"", ""BT-549"", ""J774.2"", ""NCI-H1299"", ""DLKP cell line"", ""MES-SA"", ""OV-1063"", ""MEXF514"", ""RXF 944"", ""Coronary artery smooth muscle cell line"", ""Tubulin"", ""DLD-1"", ""Bel-7402"", ""ECa-109 cell line"", ""U-937"", ""KB 3-1"", ""HeLa"", ""SW480"", ""Integrin alpha-V/beta-3"", ""LOX IMVI"", ""LNCaP"", ""Prostatic carcinoma cells"", ""TSU"", ""P-glycoprotein 1"", ""MCF7-DOX"", ""PA-1"", ""WRL68"", ""COLO 320DM"", ""Caco-2"", ""A-431"", ""HUVEC"", ""HepG2"", ""NCI-H295R"", ""ARO"", ""PT-45"", ""U-87 MG"", ""SiHa"", ""MX1"", ""Panel (12 tumour cell lines)"", ""Panel NCI-60 (60 carcinoma cell lines)"", ""NCI-H630"", ""MKN-45"", ""Jurkat"", ""Apoptosis regulator Bcl-2"", ""Apoptosis regulator Bcl-X"", ""1A9"", ""1A9/ptx-10"", ""ACHN"", ""NCI-H69"", ""T47D"", ""WI-38"", ""WI-38 VA13"", ""M21"", ""1A9/ptx-22"", ""NCI-H322M"", ""RPMI-8226"", ""SNB-75"", ""UACC-257"", ""SK-MEL-28"", ""U-937/GTB"", ""HEK293"", ""OE19"", ""OE33"", ""SW-620"", ""HT-1080"", ""BGC-823"", ""L2987"", ""MDA-MB-231"", ""LoVo"", ""HGC-27"", ""PANC-1"", ""HCT-8"", ""SNU-398"", ""SJSA-1"", ""SK-BR-3"", ""ASPC1"", ""SK-MES-1"", ""HEp-2"", ""Solute carrier family 22 member 1"", ""NCI-H358"", ""SMMC-7721"", ""NCI-H838"", ""DMS-114"", ""U2OS"", ""Col2"", ""Lu1"", ""SW626"", ""NB-4"", ""SH-SY5Y"", ""UACC-812"", ""RL"", ""SW48"", ""SGC-7901"", ""IMR-32"", ""Huh-7"", ""SK-MEL"", ""ZR-75-1"", ""DG-75"", ""769-P"", ""A-375"", ""OS-RC-2"", ""CWR22R"", ""CFPAC-1"", ""Menin/Histone-lysine N-methyltransferase MLL"", ""Prelamin-A/C"", ""ATP-dependent DNA helicase Q1"", ""Ras-related protein Rab-9A"", ""Survival motor neuron protein"", ""Serine/threonine-protein kinase mTOR"", ""Thyroid hormone receptor beta-1"", ""Microtubule-associated protein tau"", ""Hypoxia-inducible factor 1 alpha"", ""Peripheral myelin protein 22"", ""Niemann-Pick C1 protein"", ""Ubiquitin carboxyl-terminal hydrolase 2"", ""Bloom syndrome protein"", ""Thrombopoietin"", ""Cellular tumor antigen p53"", ""Endoplasmic reticulum-associated amyloid beta-peptide-binding protein"", ""Neuropeptide S receptor"", ""Geminin"", ""Nuclear factor erythroid 2-related factor 2"", ""ATPase family AAA domain-containing protein 5"", ""Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1"", ""NCI-N87"", ""LLC cell line"", ""HaCaT"", ""SK-N-SH"", ""Ataxin-2"", ""Chromobox protein homolog 1"", ""Androgen Receptor"", ""Peroxisome proliferator-activated receptor delta"", ""Estrogen receptor alpha"", ""Regulator of G-protein signaling 4"", ""Peroxisome proliferator-activated receptor gamma"", ""Mothers against decapentaplegic homolog 3"", ""Vitamin D receptor"", ""Glucocorticoid receptor"", ""Ubiquitin carboxyl-terminal hydrolase 1"", ""Retinoid X receptor alpha"", ""Cholecystokinin A receptor"", ""Melanocortin receptor 5"", ""Delta opioid receptor"", ""Tyrosine-protein kinase FYN"", ""Receptor protein-tyrosine kinase erbB-2"", ""Neurokinin 2 receptor"", ""SW1573"", ""OVCAR-5"", ""SN12C"", ""MDA-N"", ""NCI-H23"", ""HOP-92"", ""Malme-3M"", ""DMS-273"", ""TK-10"", ""XF498"", ""OVCAR-4"", ""KM-20L2"", ""EKVX"", ""LXFL 529"", ""CAKI-1"", ""SNB-78"", ""HOP-18"", ""SN12K1"", ""AGS"", ""MGC-803"", ""Multidrug resistance-associated protein 7"", ""Multidrug resistance-associated protein 1"", ""Bile salt export pump"", ""BXPC-3"", ""NCI-H2126"", ""MIA PaCa-2"", ""NUGC-3"", ""SW780"", ""OVCAR"", ""THP-1"", ""SK-HEP1"", ""Isocitrate dehydrogenase [NADP] cytoplasmic"", ""Alpha-synuclein"", ""DSH1"", ""Daudi"", ""DU-4475"", ""EHEB"", ""EM-2"", ""ES1"", ""ES5"", ""ES3"", ""ES4"", ""EB-3"", ""EB2"", ""EC-GI-10"", ""ECC4"", ""C2BBe1"", ""COLO-800"", ""DJM-1"", ""A704"", ""COLO-824"", ""COLO-829"", ""ACN"", ""C8166"", ""CA46"", ""DMS-79"", ""DOHH-2"", ""ALL-PO"", ""COR-L279"", ""COR-L88"", ""DMS-153"", ""AM-38"", ""CAL-148"", ""CP66-MEL"", ""ARH-77"", ""ATN-1"", ""CP67-MEL"", ""CPC-N"", ""CTB-1"", ""BB30-HNC"", ""CTV-1"", ""CW-2"", ""697"", ""BB49-HNC"", ""BB65-RCC"", ""BC1 cell line"", ""BC-3"", ""CAS-1"", ""Calu-6"", ""8-MG-BA"", ""BE-13"", ""A101D"", ""CESS"", ""CGTH-W-1"", ""D-247MG"", ""CHP-126"", ""D-263MG"", ""D283 Med"", ""A253 cell line"", ""BL-41"", ""BL-70"", ""BOKU"", ""CMK"", ""COLO-320-HSR"", ""D-336MG"", ""A3-KAW"", ""COLO-668"", ""D-502MG"", ""A388"", ""A4-Fuk"", ""BT-474"", ""BV-173"", ""DB"", ""Becker"", ""COLO-684"", ""DEL"", ""NCI-H1838"", ""NCI-H187"", ""NCI-H526"", ""OMC-1"", ""SK-MEL-1"", ""TGW"", ""GI-1"", ""GI-ME-N"", ""IST-SL1"", ""IST-SL2"", ""KS-1"", ""LNCaP-Clone-FGC"", ""LOUCY"", ""MFM-223"", ""NB13"", ""NB14"", ""NCI-H1882"", ""NCI-H1963"", ""NCI-H64"", ""ONS-76"", ""OPM-2"", ""RPMI 8402"", ""RPMI-8866"", ""SW684"", ""GOTO"", ""J-RT3-T3-5"", ""KU812 cell line"", ""KURAMOCHI"", ""LP-1"", ""MHH-CALL-2"", ""NB17"", ""NB5"", ""RS4-11"", ""TUR"", ""GR-ST"", ""JAR"", ""KY821"", ""LS-1034"", ""LS-123"", ""MHH-NB-11"", ""MHH-PREB-1"", ""NB6"", ""NB69"", ""NCI-H2081"", ""NCI-H716"", ""NCI-H719"", ""NCI-H720"", ""SK-MM-2"", ""SW872"", ""U-266"", ""ES6"", ""ES7"", ""GT3TKB"", ""JVM-2"", ""JVM-3"", ""LS-411N"", ""LS-513"", ""NB7"", ""NCI-H209"", ""NCI-H747"", ""Raji"", ""Ramos-2G6-4C10"", ""SK-N-DZ"", ""SK-N-FI"", ""SW 954"", ""U-698-M"", ""ES8"", ""HAL-01"", ""JIYOYE"", ""LU-134-A"", ""NCCIT"", ""NCI-H1092"", ""NCI-H2107"", ""NCI-H748"", ""NCI-H82"", ""P30-OHK"", ""P31-FUJ"", ""SBC-1"", ""SK-NEP-1"", ""SW 962"", ""SW982"", ""ETK-1"", ""HC-1"", ""HCC1187"", ""HT"", ""K052"", ""K5"", ""KALS-1"", ""LU-139"", ""LU-165"", ""ML-2"", ""MLMA"", ""NCI-H1155"", ""NCI-H128"", ""NCI-H2141"", ""NCI-H2171"", ""NCI-H889"", ""SCC-15"", ""SK-PN-DW"", ""EW-1"", ""EW-11"", ""KARPAS-299"", ""KARPAS-422"", ""L-363"", ""Lu-65"", ""LXF-289 cell line"", ""MMAC-SF"", ""MN-60"", ""NCI-H1304"", ""NCI-H1355"", ""NCI-H2196"", ""SNU1"", ""SCC-3"", ""SK-UT-1"", ""EW-12"", ""EW-13"", ""HCC1599"", ""HT-144"", ""KARPAS-45"", ""Kasumi 1"", ""L-428"", ""L-540"", ""LAMA-84"", ""MOLT-13"", ""MOLT-16"", ""NCI-H1395"", ""SNU-16"", ""SNU-5"", ""NEC8"", ""PF-382"", ""SKM-1"", ""TALL-1"", ""VA-ES-BJ"", ""EW-16"", ""EW-18"", ""KE-37"", ""KG-1"", ""LAN-6"", ""MC-CAR"", ""MONO-MAC-6"", ""NCI-H1417"", ""NCI-H1436"", ""NH-12"", ""PSN1"", ""QIMR-WIL"", ""SCH"", ""SCLC-21H"", ""SF-126"", ""TE-1"", ""EW-24"", ""EW-3"", ""HCC2157"", ""HCC2218"", ""HuTu80"", ""KGN"", ""KINGS-1"", ""LB1047-RCC"", ""LB2241-RCC"", ""MC116"", ""MPP-89"", ""MRK-nu-1"", ""NCI-H1522"", ""NKM-1"", ""NMC-G1"", ""RCC10RGB"", ""SNU-C1"", ""TE-10"", ""TE-11"", ""WSU-NHL"", ""EOL1"", ""KLE"", ""KM-H2"", ""LB2518-MEL"", ""LB373-MEL-D"", ""MDA-MB-134-VI"", ""MS-1"", ""MSTO-211H"", ""NCI-H1581"", ""NOMO-1"", ""NOS-1"", ""REH"", ""SNU-C2B"", ""ST486"", ""TE-12"", ""TE-15"", ""YT"", ""HCE-4"", ""LB647-SCLC"", ""LB771-HNC"", ""MV4-11"", ""MZ1-PC"", ""NCI-H1648"", ""NCI-H345"", ""NTERA-2-cl-D1"", ""RH-1"", ""SH-4"", ""SHP77"", ""SU-DHL-1"", ""SUP-T1"", ""TE-441-T"", ""TE-5"", ""no-10"", ""no-11"", ""HCE-T"", ""IA-LM"", ""KMOE-2"", ""KMS-12-PE"", ""KNS-42"", ""LB831-BLC"", ""LB996-RCC"", ""MZ2-MEL"", ""MZ7-mel"", ""NCI-H1650"", ""NCI-H446"", ""SIG-M5"", ""SIMA"", ""TE-6"", ""TE-8"", ""GAK"", ""HD-MY-Z"", ""HDLM-2"", ""KNS-81-FD"", ""LC-1F"", ""LC-2-ad"", ""MEG-01"", ""Mo"", ""NCI-H1694"", ""NCI-H510A"", ""OCI-AML2"", ""RL95-2"", ""TE-9"", ""GB-1"", ""GCIY"", ""HEL"", ""IM-9"", ""IMR-5"", ""LC4-1"", ""NALM-6"", ""NB1"", ""NCI-H1770"", ""NCI-H524"", ""OCUB-M"", ""RPMI-6666"", ""SK-LMS-1"", ""TGBC1TKB"", ""TGBC24TKB"", ""GDM-1"", ""HH"", ""IST-MEL1"", ""IST-MES1"", ""KP-N-RT-BM-1"", ""KP-N-YS"", ""MFH-ino"", ""NB10"", ""SNU-387"", ""A2058"", ""Tubulin beta-3 chain"", ""2008"", ""A375"", ""A431"", ""U251"", ""Epidermal growth factor receptor erbB1"", ""Fibroblast growth factor receptor 1"", ""Tyrosine-protein kinase ABL"", ""Tyrosine-protein kinase SRC"", ""RD"", ""MDA-MB-468"", ""NCI-H1975"", ""HCC1937"")",10381,TBB3,R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC R-HSA-389958 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC R-HSA-389977 Post-chaperonin tubulin folding pathway R-HSA-390466 Chaperonin-mediated protein folding R-HSA-391251 Protein folding R-HSA-392499 Metabolism of proteins,21630459 IDA GO:0005634 nucleus IEA GO:0005737 cytoplasm 21525035 IDA GO:0005874 microtubule IEA GO:0030424 axon ISS GO:0030425 dendrite IEA GO:0043025 neuronal cell body 23533145 IDA GO:0070062 extracellular exosome IEA GO:0071944 cell periphery,microtubule-based process GO:0007017 IEA mitotic nuclear division GO:0007067 IEA axon guidance 20074521 GO:0007411 IMP,GO:0003924 GTPase activity IEA GO:0005200 structural constituent of cytoskeleton IEA GO:0005515 protein binding 21044950 24021646 IPI GO:0005525 GTP binding IEA GO:0042277 peptide binding IEA,hsa04145 Phagosome - Homo sapiens (human) hsa04540 Gap junction - Homo sapiens (human) hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human),CHEMBL CHEMBL2178804,O60674,Tyrosine-protein kinase JAK2,1.0,PRIMARY,NO,Cn1cc(NC(=O)c2cnn3ccc(N)nc23)c(n1)c4cc(Cl)ccc4Cl,6,16,"InChI=1S/C17H13Cl2N7O/c1-25-8-13(15(24-25)10-6-9(18)2-3-12(10)19)22-17(27)11-7-21-26-5-4-14(20)23-16(11)26/h2-8H,1H3,(H2,20,23)(H,22,27)",NNGCTIVKZKXWGS-UHFFFAOYSA-N,"c(""NT-3 growth factor receptor"", ""Neurotrophic tyrosine kinase receptor type 2"", ""Nerve growth factor receptor Trk-A"", ""Proto-oncogene tyrosine-protein kinase ROS"", ""Tyrosine-protein kinase FYN"", ""Unchecked"", ""Tyrosine-protein kinase JAK2"")",3717,JAK2,"Interleukin-6 signaling R-HSA-1059683 Hemostasis R-HSA-109582 MAPK3 (ERK1) activation R-HSA-110056 IRS-mediated signalling R-HSA-112399 RAF-independent MAPK1/3 activation R-HSA-112409 MAPK1 (ERK2) activation R-HSA-112411 SOS-mediated signalling R-HSA-112412 GPVI-mediated activation cascade R-HSA-114604 Prolactin receptor signaling R-HSA-1170546 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 SHC1 events in ERBB2 signaling R-HSA-1250196 SHC1 events in ERBB4 signaling R-HSA-1250347 Nuclear signaling by ERBB4 R-HSA-1251985 Developmental Biology R-HSA-1266738 Cytokine Signaling in Immune system R-HSA-1280215 Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Prolonged ERK activation events R-HSA-169893 Frs2-mediated activation R-HSA-170968 ARMS-mediated activation R-HSA-170984 Signaling by EGFR R-HSA-177929 GRB2 events in EGFR signaling R-HSA-179812 SHC1 events in EGFR signaling R-HSA-180336 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signalling to p38 via RIT and RIN R-HSA-187706 Signaling by FGFR R-HSA-190236 Signaling by VEGF R-HSA-194138 GRB2 events in ERBB2 signaling R-HSA-1963640 DAP12 interactions R-HSA-2172127 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Signaling by Leptin R-HSA-2586552 FCERI mediated MAPK activation R-HSA-2871796 RMTs methylate histone arginines R-HSA-3214858 Chromatin modifying enzymes R-HSA-3247509 Signaling by GPCR R-HSA-372790 NCAM signaling for neurite out-growth R-HSA-375165 GPCR downstream signaling R-HSA-388396 G beta:gamma signalling through PI3Kgamma R-HSA-392451 G-protein beta:gamma signalling R-HSA-397795 Axon guidance R-HSA-422475 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signaling by Interleukins R-HSA-449147 Interleukin-2 signaling R-HSA-451927 Chromatin organization R-HSA-4839726 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 VEGFR2 mediated cell proliferation R-HSA-5218921 Downstream signaling of activated FGFR1 R-HSA-5654687 FRS-mediated FGFR1 signaling R-HSA-5654693 Downstream signaling of activated FGFR2 R-HSA-5654696 FRS-mediated FGFR2 signaling R-HSA-5654700 FRS-mediated FGFR3 signaling R-HSA-5654706 Downstream signaling of activated FGFR3 R-HSA-5654708 FRS-mediated FGFR4 signaling R-HSA-5654712 Downstream signaling of activated FGFR4 R-HSA-5654716 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 RAF activation R-HSA-5673000 RAF/MAP kinase cascade R-HSA-5673001 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Platelet activation, signaling and aggregation R-HSA-76002 Interferon gamma signaling R-HSA-877300 Regulation of IFNG signaling R-HSA-877312 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 Interleukin receptor SHC signaling R-HSA-912526 Interferon Signaling R-HSA-913531 Growth hormone receptor signaling R-HSA-982772 Factors involved in megakaryocyte development and platelet production R-HSA-983231",nucleus GO:0005634 10502458 19783980 IDA nucleoplasm GO:0005654 TAS cytoplasm GO:0005737 10502458 IDA cytosol GO:0005829 TAS cytoskeleton GO:0005856 IEA caveola GO:0005901 ISS nuclear matrix GO:0016363 IEA extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA endosome lumen GO:0031904 TAS membrane raft GO:0045121 ISS,"GO:0000165 MAPK cascade TAS GO:0000186 activation of MAPKK activity IEA GO:0002250 adaptive immune response IEA 9670957 GO:0006468 protein phosphorylation TAS GO:0006915 apoptotic process ISS GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process ISS 9670957 GO:0006928 movement of cell or subcellular component TAS GO:0007165 signal transduction ISS GO:0007167 enzyme linked receptor protein signaling pathway ISS GO:0007186 G-protein coupled receptor signaling pathway IEA GO:0007204 positive regulation of cytosolic calcium ion concentration IEA 9670957 GO:0007259 JAK-STAT cascade TAS GO:0007260 tyrosine phosphorylation of STAT protein IBA GO:0007260 tyrosine phosphorylation of STAT protein ISS GO:0007262 STAT protein import into nucleus ISS 9590174 GO:0007498 mesoderm development TAS GO:0007596 blood coagulation TAS GO:0008284 positive regulation of cell proliferation IEA GO:0008285 negative regulation of cell proliferation ISS GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IEA GO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA 10925297 GO:0010811 positive regulation of cell-substrate adhesion IDA GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISS GO:0016477 cell migration IBA GO:0018108 peptidyl-tyrosine phosphorylation ISS 8609418 GO:0019221 cytokine-mediated signaling pathway IDA GO:0019221 cytokine-mediated signaling pathway ISS GO:0022408 negative regulation of cell-cell adhesion IEA 10925297 GO:0030041 actin filament polymerization NAS GO:0030154 cell differentiation ISS GO:0030218 erythrocyte differentiation IBA GO:0030218 erythrocyte differentiation ISS GO:0030335 positive regulation of cell migration IEA GO:0031103 axon regeneration IEA GO:0031959 mineralocorticoid receptor signaling pathway IEA GO:0032024 positive regulation of insulin secretion IEA GO:0032496 response to lipopolysaccharide ISS GO:0032516 positive regulation of phosphoprotein phosphatase activity IEA GO:0032731 positive regulation of interleukin-1 beta production IEA GO:0032760 positive regulation of tumor necrosis factor production ISS GO:0033160 positive regulation of protein import into nucleus, translocation IEA GO:0033194 response to hydroperoxide IEA 8609418 GO:0033209 tumor necrosis factor-mediated signaling pathway IDA 8609418 GO:0034612 response to tumor necrosis factor IDA 19783980 GO:0035409 histone H3-Y41 phosphorylation IDA GO:0035556 intracellular signal transduction ISS 7528775 GO:0035722 interleukin-12-mediated signaling pathway IDA GO:0038083 peptidyl-tyrosine autophosphorylation IBA GO:0042127 regulation of cell proliferation IBA GO:0042503 tyrosine phosphorylation of Stat3 protein IEA GO:0042506 tyrosine phosphorylation of Stat5 protein IEA GO:0042508 tyrosine phosphorylation of Stat1 protein IEA GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein ISS GO:0042523 positive regulation of tyrosine phosphorylation of Stat5 protein ISS GO:0042977 activation of JAK2 kinase activity ISS GO:0042981 regulation of apoptotic process IBA GO:0043388 positive regulation of DNA binding IEA GO:0043392 negative regulation of DNA binding ISS GO:0043524 negative regulation of neuron apoptotic process IEA GO:0043547 positive regulation of GTPase activity IEA GO:0045087 innate immune response IBA GO:0045429 positive regulation of nitric oxide biosynthetic process IEA GO:0045597 positive regulation of cell differentiation IEA GO:0045822 negative regulation of heart contraction IEA 16280321 GO:0046677 response to antibiotic IDA GO:0046777 protein autophosphorylation ISS GO:0048008 platelet-derived growth factor receptor signaling pathway IEA 10925297 GO:0050727 regulation of inflammatory response IDA GO:0050729 positive regulation of inflammatory response IEA GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation ISS GO:0050867 positive regulation of cell activation IEA GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity IEA GO:0051770 positive regulation of nitric-oxide synthase biosynthetic process ISS GO:0060333 interferon-gamma-mediated signaling pathway TAS GO:0060334 regulation of interferon-gamma-mediated signaling pathway TAS 10925297 GO:0060396 growth hormone receptor signaling pathway IDA GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway ISS GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway TAS GO:0060399 positive regulation of growth hormone receptor signaling pathway ISS GO:0061180 mammary gland epithelium development ISS 7528775 GO:0070671 response to interleukin-12 IDA GO:0097191 extrinsic apoptotic signaling pathway ISS GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ISS",GO:0004672 protein kinase activity 9670957 NAS GO:0004713 protein tyrosine kinase activity 9111318 15143187 20304997 EXP GO:0004713 protein tyrosine kinase activity 23061660 IDA GO:0004713 protein tyrosine kinase activity ISS GO:0004713 protein tyrosine kinase activity TAS GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS GO:0005088 Ras guanyl-nucleotide exchange factor activity TAS GO:0005102 receptor binding 11201744 IPI GO:0005131 growth hormone receptor binding IBA GO:0005131 growth hormone receptor binding ISS GO:0005143 interleukin-12 receptor binding ISS GO:0005515 protein binding 11679576 11694501 11970898 15821101 16437163 17474147 18692472 21806020 24931576 IPI GO:0005524 ATP binding IEA GO:0008022 protein C-terminus binding IEA GO:0019901 protein kinase binding 10925297 IDA GO:0020037 heme binding 21036157 IDA GO:0031702 type 1 angiotensin receptor binding IEA GO:0033130 acetylcholine receptor binding IEA GO:0035401 histone kinase activity (H3-Y41 specific) 19783980 IDA GO:0042169 SH2 domain binding 9727029 IPI GO:0042393 histone binding 19783980 IDA GO:0043548 phosphatidylinositol 3-kinase binding IEA GO:0043560 insulin receptor substrate binding IEA GO:0046872 metal ion binding IEA GO:0051428 peptide hormone receptor binding IEA,hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa04920 Adipocytokine signaling pathway - Homo sapiens (human) hsa05140 Leishmaniasis - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05152 Tuberculosis - Homo sapiens (human) hsa05162 Measles - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05168 Herpes simplex infection - Homo sapiens (human),CHEMBL CHEMBL173453,P12931,Tyrosine-protein kinase SRC,1.0,ORTHOGONAL,NO,Nc1ncnc2c1c(cn2c3ccc(CNCCO)cc3)c4ccccc4,4,7,"InChI=1S/C21H21N5O/c22-20-19-18(16-4-2-1-3-5-16)13-26(21(19)25-14-24-20)17-8-6-15(7-9-17)12-23-10-11-27/h1-9,13-14,23,27H,10-12H2,(H2,22,24,25)",WGNQPAWFLWLKBL-UHFFFAOYSA-N,"c(""Epidermal growth factor receptor erbB1"", ""Tyrosine-protein kinase ABL"", ""Cyclin-dependent kinase 1"", ""Tyrosine-protein kinase SRC"", ""Tyrosine-protein kinase CSK"")",6714,SRC,"Hemostasis R-HSA-109582 IRS-mediated signalling R-HSA-112399 SOS-mediated signalling R-HSA-112412 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 SHC1 events in ERBB2 signaling R-HSA-1250196 SHC1 events in ERBB4 signaling R-HSA-1250347 Developmental Biology R-HSA-1266738 Cytokine Signaling in Immune system R-HSA-1280215 Adaptive Immune System R-HSA-1280218 Spry regulation of FGF signaling R-HSA-1295596 Signaling by SCF-KIT R-HSA-1433557 Regulation of KIT signaling R-HSA-1433559 Cell-Cell communication R-HSA-1500931 Gap junction trafficking and regulation R-HSA-157858 Signal Transduction R-HSA-162582 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Prolonged ERK activation events R-HSA-169893 Frs2-mediated activation R-HSA-170968 ARMS-mediated activation R-HSA-170984 p38MAPK events R-HSA-171007 Signaling by EGFR R-HSA-177929 GRB2 events in EGFR signaling R-HSA-179812 GAB1 signalosome R-HSA-180292 SHC1 events in EGFR signaling R-HSA-180336 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signalling to p38 via RIT and RIN R-HSA-187706 Signaling by FGFR R-HSA-190236 c-src mediated regulation of Cx43 function and closure of gap junctions R-HSA-191647 Regulation of gap junction activity R-HSA-191650 Signaling by VEGF R-HSA-194138 Signaling by Rho GTPases R-HSA-194315 RHO GTPase Effectors R-HSA-195258 GRB2 events in ERBB2 signaling R-HSA-1963640 Membrane Trafficking R-HSA-199991 Cell surface interactions at the vascular wall R-HSA-202733 PECAM1 interactions R-HSA-210990 DAP12 interactions R-HSA-2172127 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Signaling by Leptin R-HSA-2586552 EPH-Ephrin signaling R-HSA-2682334 FCERI mediated MAPK activation R-HSA-2871796 Integrin alphaIIb beta3 signaling R-HSA-354192 GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 p130Cas linkage to MAPK signaling for integrins R-HSA-372708 Signaling by GPCR R-HSA-372790 Netrin-1 signaling R-HSA-373752 L1CAM interactions R-HSA-373760 NCAM signaling for neurite out-growth R-HSA-375165 Costimulation by the CD28 family R-HSA-388841 CD28 co-stimulation R-HSA-389356 CTLA4 inhibitory signaling R-HSA-389513 Signal regulatory protein (SIRP) family interactions R-HSA-391160 EPHB-mediated forward signaling R-HSA-3928662 EPHA-mediated growth cone collapse R-HSA-3928663 Ephrin signaling R-HSA-3928664 EPH-ephrin mediated repulsion of cells R-HSA-3928665 DCC mediated attractive signaling R-HSA-418885 Netrin mediated repulsion signals R-HSA-418886 Axon guidance R-HSA-422475 GP1b-IX-V activation signalling R-HSA-430116 Recycling pathway of L1 R-HSA-437239 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signaling by Interleukins R-HSA-449147 Interleukin-2 signaling R-HSA-451927 Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 VEGFR2 mediated cell proliferation R-HSA-5218921 CLEC7A (Dectin-1) signaling R-HSA-5607764 C-type lectin receptors (CLRs) R-HSA-5621481 Vesicle-mediated transport R-HSA-5653656 Downstream signaling of activated FGFR1 R-HSA-5654687 FRS-mediated FGFR1 signaling R-HSA-5654693 Downstream signaling of activated FGFR2 R-HSA-5654696 FRS-mediated FGFR2 signaling R-HSA-5654700 FRS-mediated FGFR3 signaling R-HSA-5654706 Downstream signaling of activated FGFR3 R-HSA-5654708 FRS-mediated FGFR4 signaling R-HSA-5654712 Downstream signaling of activated FGFR4 R-HSA-5654716 Negative regulation of FGFR1 signaling R-HSA-5654726 Negative regulation of FGFR2 signaling R-HSA-5654727 Negative regulation of FGFR3 signaling R-HSA-5654732 Negative regulation of FGFR4 signaling R-HSA-5654733 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 RHO GTPases Activate Formins R-HSA-5663220 RAF activation R-HSA-5673000 RAF/MAP kinase cascade R-HSA-5673001 MAP2K and MAPK activation R-HSA-5674135 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Platelet activation, signaling and aggregation R-HSA-76002 Platelet Aggregation (Plug Formation) R-HSA-76009 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 Interleukin receptor SHC signaling R-HSA-912526",IEA GO:0005634 nucleus IDA 16441665 cytoplasm GO:0005737 IDA 19767770 mitochondrion GO:0005739 IDA 12615910 mitochondrial inner membrane GO:0005743 IDA 20605918 lysosome GO:0005764 IDA 20605918 late endosome GO:0005770 IDA 19767770 cytosol GO:0005829 TAS GO:0005829 cytosol IEA GO:0005884 actin filament IDA 20605918 plasma membrane GO:0005886 TAS GO:0005886 plasma membrane IDA 17848177 caveola GO:0005901 IEA GO:0014069 postsynaptic density IBA GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA GO:0032587 ruffle membrane IEA GO:0043005 neuron projection IEA GO:0048471 perinuclear region of cytoplasm IDA 19056867 20458337 23376485 extracellular exosome GO:0070062,"GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS GO:0007049 cell cycle IEA 9020193 10734107 GO:0007165 signal transduction TAS 9924018 GO:0007172 signal complex assembly TAS GO:0007173 epidermal growth factor receptor signaling pathway IBA GO:0007173 epidermal growth factor receptor signaling pathway TAS 24036928 GO:0007179 transforming growth factor beta receptor signaling pathway IMP 24036928 GO:0007229 integrin-mediated signaling pathway IMP GO:0007417 central nervous system development IBA GO:0008283 cell proliferation IEA GO:0009612 response to mechanical stimulus IEA GO:0009615 response to virus IEA GO:0010447 response to acidic pH IEA 21724833 GO:0010632 regulation of epithelial cell migration IMP 18054784 GO:0010634 positive regulation of epithelial cell migration IMP GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway IEA GO:0010907 positive regulation of glucose metabolic process IEA GO:0014911 positive regulation of smooth muscle cell migration IEA GO:0016032 viral process IEA GO:0016337 single organismal cell-cell adhesion IEA GO:0018105 peptidyl-serine phosphorylation IEA 22732588 GO:0018108 peptidyl-tyrosine phosphorylation IDA 21724833 GO:0022407 regulation of cell-cell adhesion IMP GO:0030168 platelet activation TAS GO:0030520 intracellular estrogen receptor signaling pathway IBA GO:0030900 forebrain development IEA GO:0031295 T cell costimulation TAS GO:0031648 protein destabilization IEA GO:0031667 response to nutrient levels IEA GO:0031954 positive regulation of protein autophosphorylation IEA GO:0032148 activation of protein kinase B activity IEA 21531765 GO:0032211 negative regulation of telomere maintenance via telomerase IMP 19767770 GO:0032463 negative regulation of protein homooligomerization IMP GO:0032869 cellular response to insulin stimulus IEA GO:0033146 regulation of intracellular estrogen receptor signaling pathway IEA 19267251 GO:0033625 positive regulation of integrin activation TAS GO:0034332 adherens junction organization IEA GO:0034446 substrate adhesion-dependent cell spreading IEA GO:0034614 cellular response to reactive oxygen species IEA 15248232 GO:0035556 intracellular signal transduction IDA GO:0036035 osteoclast development IBA GO:0036120 cellular response to platelet-derived growth factor stimulus IEA GO:0038083 peptidyl-tyrosine autophosphorylation IBA GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS GO:0038128 ERBB2 signaling pathway TAS GO:0042127 regulation of cell proliferation IBA GO:0042493 response to drug IEA GO:0042542 response to hydrogen peroxide IEA GO:0043065 positive regulation of apoptotic process IEA 19767770 GO:0043066 negative regulation of apoptotic process IMP 19267251 GO:0043114 regulation of vascular permeability TAS 24036928 GO:0043149 stress fiber assembly IMP 19767770 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP GO:0043393 regulation of protein binding IEA GO:0043406 positive regulation of MAP kinase activity IEA GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA GO:0045056 transcytosis IEA GO:0045087 innate immune response IBA 19267251 GO:0045124 regulation of bone resorption TAS GO:0045453 bone resorption ISS GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA GO:0045892 negative regulation of transcription, DNA-templated IEA GO:0045893 positive regulation of transcription, DNA-templated IEA GO:0046628 positive regulation of insulin receptor signaling pathway IEA 16441665 GO:0046777 protein autophosphorylation IDA GO:0048008 platelet-derived growth factor receptor signaling pathway IBA GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS GO:0048011 neurotrophin TRK receptor signaling pathway IEA GO:0048013 ephrin receptor signaling pathway TAS GO:0048477 oogenesis IEA GO:0050715 positive regulation of cytokine secretion IEA 18054784 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IC GO:0050847 progesterone receptor signaling pathway IBA GO:0050847 progesterone receptor signaling pathway ISS GO:0050900 leukocyte migration TAS GO:0051385 response to mineralocorticoid IEA GO:0051602 response to electrical stimulus IEA GO:0051726 regulation of cell cycle IBA GO:0051895 negative regulation of focal adhesion assembly ISS 19767770 GO:0051897 positive regulation of protein kinase B signaling IMP 19767770 GO:0051902 negative regulation of mitochondrial depolarization IMP 21531765 GO:0051974 negative regulation of telomerase activity IMP GO:0060065 uterus development IEA GO:0060444 branching involved in mammary gland duct morphogenesis IEA GO:0060491 regulation of cell projection assembly IEA GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA 19281832 GO:0070555 response to interleukin-1 IMP GO:0071222 cellular response to lipopolysaccharide IEA GO:0071375 cellular response to peptide hormone stimulus ISS GO:0071393 cellular response to progesterone stimulus ISS GO:0071398 cellular response to fatty acid IEA GO:0071456 cellular response to hypoxia IEA GO:0071498 cellular response to fluid shear stress IEA GO:0071801 regulation of podosome assembly IBA GO:0071803 positive regulation of podosome assembly IEA 19059439 GO:0071902 positive regulation of protein serine/threonine kinase activity IDA GO:0086098 angiotensin-activated signaling pathway involved in heart process ISS GO:0090263 positive regulation of canonical Wnt signaling pathway IEA 18054784 GO:2000394 positive regulation of lamellipodium morphogenesis IMP GO:2000573 positive regulation of DNA biosynthetic process IEA 21724833 GO:2000641 regulation of early endosome to late endosome transport IMP 22402981 GO:2000811 negative regulation of anoikis IMP 19767770 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP 19767770 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway IMP 21724833 GO:2001286 regulation of caveolin-mediated endocytosis IMP",18616680 GO:0004672 protein kinase activity IDA GO:0004672 protein kinase activity TAS 1381360 9799234 10861086 11448999 12923167 15735019 16921024 17030621 18697750 GO:0004713 protein tyrosine kinase activity EXP 16441665 19059439 GO:0004713 protein tyrosine kinase activity IDA GO:0004713 protein tyrosine kinase activity TAS 19267251 GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS 9020193 GO:0005070 SH3/SH2 adaptor activity TAS GO:0005080 protein kinase C binding IEA 19332538 GO:0005102 receptor binding IPI GO:0005158 insulin receptor binding IEA 19267251 GO:0005178 integrin binding TAS 7478590 7537265 8070403 8681387 8849729 9148935 9162084 9600099 9763511 10521452 10542110 10698938 10801826 11007774 11149930 11741929 11923305 11940572 12857726 14963108 15143158 15546919 15735685 15749833 15866871 16115959 16169070 16273093 16291744 16374509 16479011 16511561 16537444 16636290 16741966 16899217 16964398 16966330 17038317 17092689 17094785 17141222 17170700 17178840 17284441 17318191 17412687 17474147 17491594 17525734 17936276 17974954 18070987 18155796 18273061 18328427 18377662 18464795 18662404 19262695 19372587 19419966 19661922 19732724 19903481 19910644 20100835 20158519 20624308 20935677 21034468 21075308 21278788 21685945 22402981 22439932 22581261 23065768 23397142 23564345 23954233 24034250 24658140 24728074 25117710 25241761 25814554 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0008022 protein C-terminus binding IEA GO:0016301 kinase activity TAS 21724833 GO:0019899 enzyme binding IPI 19059439 GO:0019900 kinase binding IPI 21036157 GO:0020037 heme binding IDA GO:0030331 estrogen receptor binding IEA 8070403 GO:0042169 SH2 domain binding IPI 8953041 12538589 GO:0044325 ion channel binding IPI 12925710 GO:0046875 ephrin receptor binding IPI 16441665 GO:0051219 phosphoprotein binding IPI GO:0051427 hormone receptor binding IBA 16479011 GO:0070851 growth factor receptor binding IPI 25006397 GO:0097110 scaffold protein binding IPI,hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04144 Endocytosis - Homo sapiens (human) hsa04370 VEGF signaling pathway - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04520 Adherens junction - Homo sapiens (human) hsa04530 Tight junction - Homo sapiens (human) hsa04540 Gap junction - Homo sapiens (human) hsa04611 Platelet activation - Homo sapiens (human) hsa04727 GABAergic synapse - Homo sapiens (human) hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04912 GnRH signaling pathway - Homo sapiens (human) hsa04915 Estrogen signaling pathway - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04921 Oxytocin signaling pathway - Homo sapiens (human) hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human) hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) hsa05131 Shigellosis - Homo sapiens (human) hsa05152 Tuberculosis - Homo sapiens (human) hsa05161 Hepatitis B - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05219 Bladder cancer - Homo sapiens (human),CHEMBL CHEMBL170984,P12931,Tyrosine-protein kinase SRC,1.0,PRIMARY,NO,COc1cc2c(Nc3c(Cl)ccc4OCOc34)ncnc2cc1OCC5CCN(C)CC5,6,9,"InChI=1S/C23H25ClN4O4/c1-28-7-5-14(6-8-28)11-30-20-10-17-15(9-19(20)29-2)23(26-12-25-17)27-21-16(24)3-4-18-22(21)32-13-31-18/h3-4,9-10,12,14H,5-8,11,13H2,1-2H3,(H,25,26,27)",UYKYCBACTCRLLP-UHFFFAOYSA-N,"c(""Tyrosine-protein kinase SRC"", ""Vascular endothelial growth factor receptor 2"", ""A549"", ""Vascular endothelial growth factor receptor 1"", ""Fibroblast growth factor receptor 1"", ""Tyrosine-protein kinase TIE-2"", ""Tyrosine-protein kinase CSK"")",6714,SRC,"Hemostasis R-HSA-109582 IRS-mediated signalling R-HSA-112399 SOS-mediated signalling R-HSA-112412 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 SHC1 events in ERBB2 signaling R-HSA-1250196 SHC1 events in ERBB4 signaling R-HSA-1250347 Developmental Biology R-HSA-1266738 Cytokine Signaling in Immune system R-HSA-1280215 Adaptive Immune System R-HSA-1280218 Spry regulation of FGF signaling R-HSA-1295596 Signaling by SCF-KIT R-HSA-1433557 Regulation of KIT signaling R-HSA-1433559 Cell-Cell communication R-HSA-1500931 Gap junction trafficking and regulation R-HSA-157858 Signal Transduction R-HSA-162582 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Prolonged ERK activation events R-HSA-169893 Frs2-mediated activation R-HSA-170968 ARMS-mediated activation R-HSA-170984 p38MAPK events R-HSA-171007 Signaling by EGFR R-HSA-177929 GRB2 events in EGFR signaling R-HSA-179812 GAB1 signalosome R-HSA-180292 SHC1 events in EGFR signaling R-HSA-180336 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signalling to p38 via RIT and RIN R-HSA-187706 Signaling by FGFR R-HSA-190236 c-src mediated regulation of Cx43 function and closure of gap junctions R-HSA-191647 Regulation of gap junction activity R-HSA-191650 Signaling by VEGF R-HSA-194138 Signaling by Rho GTPases R-HSA-194315 RHO GTPase Effectors R-HSA-195258 GRB2 events in ERBB2 signaling R-HSA-1963640 Membrane Trafficking R-HSA-199991 Cell surface interactions at the vascular wall R-HSA-202733 PECAM1 interactions R-HSA-210990 DAP12 interactions R-HSA-2172127 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Signaling by Leptin R-HSA-2586552 EPH-Ephrin signaling R-HSA-2682334 FCERI mediated MAPK activation R-HSA-2871796 Integrin alphaIIb beta3 signaling R-HSA-354192 GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-354194 p130Cas linkage to MAPK signaling for integrins R-HSA-372708 Signaling by GPCR R-HSA-372790 Netrin-1 signaling R-HSA-373752 L1CAM interactions R-HSA-373760 NCAM signaling for neurite out-growth R-HSA-375165 Costimulation by the CD28 family R-HSA-388841 CD28 co-stimulation R-HSA-389356 CTLA4 inhibitory signaling R-HSA-389513 Signal regulatory protein (SIRP) family interactions R-HSA-391160 EPHB-mediated forward signaling R-HSA-3928662 EPHA-mediated growth cone collapse R-HSA-3928663 Ephrin signaling R-HSA-3928664 EPH-ephrin mediated repulsion of cells R-HSA-3928665 DCC mediated attractive signaling R-HSA-418885 Netrin mediated repulsion signals R-HSA-418886 Axon guidance R-HSA-422475 GP1b-IX-V activation signalling R-HSA-430116 Recycling pathway of L1 R-HSA-437239 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signaling by Interleukins R-HSA-449147 Interleukin-2 signaling R-HSA-451927 Thrombin signalling through proteinase activated receptors (PARs) R-HSA-456926 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 VEGFR2 mediated cell proliferation R-HSA-5218921 CLEC7A (Dectin-1) signaling R-HSA-5607764 C-type lectin receptors (CLRs) R-HSA-5621481 Vesicle-mediated transport R-HSA-5653656 Downstream signaling of activated FGFR1 R-HSA-5654687 FRS-mediated FGFR1 signaling R-HSA-5654693 Downstream signaling of activated FGFR2 R-HSA-5654696 FRS-mediated FGFR2 signaling R-HSA-5654700 FRS-mediated FGFR3 signaling R-HSA-5654706 Downstream signaling of activated FGFR3 R-HSA-5654708 FRS-mediated FGFR4 signaling R-HSA-5654712 Downstream signaling of activated FGFR4 R-HSA-5654716 Negative regulation of FGFR1 signaling R-HSA-5654726 Negative regulation of FGFR2 signaling R-HSA-5654727 Negative regulation of FGFR3 signaling R-HSA-5654732 Negative regulation of FGFR4 signaling R-HSA-5654733 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 RHO GTPases Activate Formins R-HSA-5663220 RAF activation R-HSA-5673000 RAF/MAP kinase cascade R-HSA-5673001 MAP2K and MAPK activation R-HSA-5674135 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Platelet activation, signaling and aggregation R-HSA-76002 Platelet Aggregation (Plug Formation) R-HSA-76009 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 Interleukin receptor SHC signaling R-HSA-912526",IEA GO:0005634 nucleus IDA 16441665 cytoplasm GO:0005737 IDA 19767770 mitochondrion GO:0005739 IDA 12615910 mitochondrial inner membrane GO:0005743 IDA 20605918 lysosome GO:0005764 IDA 20605918 late endosome GO:0005770 IDA 19767770 cytosol GO:0005829 TAS GO:0005829 cytosol IEA GO:0005884 actin filament IDA 20605918 plasma membrane GO:0005886 TAS GO:0005886 plasma membrane IDA 17848177 caveola GO:0005901 IEA GO:0014069 postsynaptic density IBA GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA GO:0032587 ruffle membrane IEA GO:0043005 neuron projection IEA GO:0048471 perinuclear region of cytoplasm IDA 19056867 20458337 23376485 extracellular exosome GO:0070062,"GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS GO:0007049 cell cycle IEA 9020193 10734107 GO:0007165 signal transduction TAS 9924018 GO:0007172 signal complex assembly TAS GO:0007173 epidermal growth factor receptor signaling pathway IBA GO:0007173 epidermal growth factor receptor signaling pathway TAS 24036928 GO:0007179 transforming growth factor beta receptor signaling pathway IMP 24036928 GO:0007229 integrin-mediated signaling pathway IMP GO:0007417 central nervous system development IBA GO:0008283 cell proliferation IEA GO:0009612 response to mechanical stimulus IEA GO:0009615 response to virus IEA GO:0010447 response to acidic pH IEA 21724833 GO:0010632 regulation of epithelial cell migration IMP 18054784 GO:0010634 positive regulation of epithelial cell migration IMP GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway IEA GO:0010907 positive regulation of glucose metabolic process IEA GO:0014911 positive regulation of smooth muscle cell migration IEA GO:0016032 viral process IEA GO:0016337 single organismal cell-cell adhesion IEA GO:0018105 peptidyl-serine phosphorylation IEA 22732588 GO:0018108 peptidyl-tyrosine phosphorylation IDA 21724833 GO:0022407 regulation of cell-cell adhesion IMP GO:0030168 platelet activation TAS GO:0030520 intracellular estrogen receptor signaling pathway IBA GO:0030900 forebrain development IEA GO:0031295 T cell costimulation TAS GO:0031648 protein destabilization IEA GO:0031667 response to nutrient levels IEA GO:0031954 positive regulation of protein autophosphorylation IEA GO:0032148 activation of protein kinase B activity IEA 21531765 GO:0032211 negative regulation of telomere maintenance via telomerase IMP 19767770 GO:0032463 negative regulation of protein homooligomerization IMP GO:0032869 cellular response to insulin stimulus IEA GO:0033146 regulation of intracellular estrogen receptor signaling pathway IEA 19267251 GO:0033625 positive regulation of integrin activation TAS GO:0034332 adherens junction organization IEA GO:0034446 substrate adhesion-dependent cell spreading IEA GO:0034614 cellular response to reactive oxygen species IEA 15248232 GO:0035556 intracellular signal transduction IDA GO:0036035 osteoclast development IBA GO:0036120 cellular response to platelet-derived growth factor stimulus IEA GO:0038083 peptidyl-tyrosine autophosphorylation IBA GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS GO:0038128 ERBB2 signaling pathway TAS GO:0042127 regulation of cell proliferation IBA GO:0042493 response to drug IEA GO:0042542 response to hydrogen peroxide IEA GO:0043065 positive regulation of apoptotic process IEA 19767770 GO:0043066 negative regulation of apoptotic process IMP 19267251 GO:0043114 regulation of vascular permeability TAS 24036928 GO:0043149 stress fiber assembly IMP 19767770 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP GO:0043393 regulation of protein binding IEA GO:0043406 positive regulation of MAP kinase activity IEA GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA GO:0045056 transcytosis IEA GO:0045087 innate immune response IBA 19267251 GO:0045124 regulation of bone resorption TAS GO:0045453 bone resorption ISS GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity IEA GO:0045892 negative regulation of transcription, DNA-templated IEA GO:0045893 positive regulation of transcription, DNA-templated IEA GO:0046628 positive regulation of insulin receptor signaling pathway IEA 16441665 GO:0046777 protein autophosphorylation IDA GO:0048008 platelet-derived growth factor receptor signaling pathway IBA GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS GO:0048011 neurotrophin TRK receptor signaling pathway IEA GO:0048013 ephrin receptor signaling pathway TAS GO:0048477 oogenesis IEA GO:0050715 positive regulation of cytokine secretion IEA 18054784 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IC GO:0050847 progesterone receptor signaling pathway IBA GO:0050847 progesterone receptor signaling pathway ISS GO:0050900 leukocyte migration TAS GO:0051385 response to mineralocorticoid IEA GO:0051602 response to electrical stimulus IEA GO:0051726 regulation of cell cycle IBA GO:0051895 negative regulation of focal adhesion assembly ISS 19767770 GO:0051897 positive regulation of protein kinase B signaling IMP 19767770 GO:0051902 negative regulation of mitochondrial depolarization IMP 21531765 GO:0051974 negative regulation of telomerase activity IMP GO:0060065 uterus development IEA GO:0060444 branching involved in mammary gland duct morphogenesis IEA GO:0060491 regulation of cell projection assembly IEA GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA 19281832 GO:0070555 response to interleukin-1 IMP GO:0071222 cellular response to lipopolysaccharide IEA GO:0071375 cellular response to peptide hormone stimulus ISS GO:0071393 cellular response to progesterone stimulus ISS GO:0071398 cellular response to fatty acid IEA GO:0071456 cellular response to hypoxia IEA GO:0071498 cellular response to fluid shear stress IEA GO:0071801 regulation of podosome assembly IBA GO:0071803 positive regulation of podosome assembly IEA 19059439 GO:0071902 positive regulation of protein serine/threonine kinase activity IDA GO:0086098 angiotensin-activated signaling pathway involved in heart process ISS GO:0090263 positive regulation of canonical Wnt signaling pathway IEA 18054784 GO:2000394 positive regulation of lamellipodium morphogenesis IMP GO:2000573 positive regulation of DNA biosynthetic process IEA 21724833 GO:2000641 regulation of early endosome to late endosome transport IMP 22402981 GO:2000811 negative regulation of anoikis IMP 19767770 GO:2001237 negative regulation of extrinsic apoptotic signaling pathway IMP 19767770 GO:2001243 negative regulation of intrinsic apoptotic signaling pathway IMP 21724833 GO:2001286 regulation of caveolin-mediated endocytosis IMP",18616680 GO:0004672 protein kinase activity IDA GO:0004672 protein kinase activity TAS 1381360 9799234 10861086 11448999 12923167 15735019 16921024 17030621 18697750 GO:0004713 protein tyrosine kinase activity EXP 16441665 19059439 GO:0004713 protein tyrosine kinase activity IDA GO:0004713 protein tyrosine kinase activity TAS 19267251 GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS 9020193 GO:0005070 SH3/SH2 adaptor activity TAS GO:0005080 protein kinase C binding IEA 19332538 GO:0005102 receptor binding IPI GO:0005158 insulin receptor binding IEA 19267251 GO:0005178 integrin binding TAS 7478590 7537265 8070403 8681387 8849729 9148935 9162084 9600099 9763511 10521452 10542110 10698938 10801826 11007774 11149930 11741929 11923305 11940572 12857726 14963108 15143158 15546919 15735685 15749833 15866871 16115959 16169070 16273093 16291744 16374509 16479011 16511561 16537444 16636290 16741966 16899217 16964398 16966330 17038317 17092689 17094785 17141222 17170700 17178840 17284441 17318191 17412687 17474147 17491594 17525734 17936276 17974954 18070987 18155796 18273061 18328427 18377662 18464795 18662404 19262695 19372587 19419966 19661922 19732724 19903481 19910644 20100835 20158519 20624308 20935677 21034468 21075308 21278788 21685945 22402981 22439932 22581261 23065768 23397142 23564345 23954233 24034250 24658140 24728074 25117710 25241761 25814554 GO:0005515 protein binding IPI GO:0005524 ATP binding IEA GO:0008022 protein C-terminus binding IEA GO:0016301 kinase activity TAS 21724833 GO:0019899 enzyme binding IPI 19059439 GO:0019900 kinase binding IPI 21036157 GO:0020037 heme binding IDA GO:0030331 estrogen receptor binding IEA 8070403 GO:0042169 SH2 domain binding IPI 8953041 12538589 GO:0044325 ion channel binding IPI 12925710 GO:0046875 ephrin receptor binding IPI 16441665 GO:0051219 phosphoprotein binding IPI GO:0051427 hormone receptor binding IBA 16479011 GO:0070851 growth factor receptor binding IPI 25006397 GO:0097110 scaffold protein binding IPI,hsa04012 ErbB signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04062 Chemokine signaling pathway - Homo sapiens (human) hsa04144 Endocytosis - Homo sapiens (human) hsa04370 VEGF signaling pathway - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa04520 Adherens junction - Homo sapiens (human) hsa04530 Tight junction - Homo sapiens (human) hsa04540 Gap junction - Homo sapiens (human) hsa04611 Platelet activation - Homo sapiens (human) hsa04727 GABAergic synapse - Homo sapiens (human) hsa04750 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human) hsa04912 GnRH signaling pathway - Homo sapiens (human) hsa04915 Estrogen signaling pathway - Homo sapiens (human) hsa04917 Prolactin signaling pathway - Homo sapiens (human) hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human) hsa04921 Oxytocin signaling pathway - Homo sapiens (human) hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human) hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) hsa05131 Shigellosis - Homo sapiens (human) hsa05152 Tuberculosis - Homo sapiens (human) hsa05161 Hepatitis B - Homo sapiens (human) hsa05203 Viral carcinogenesis - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human) hsa05219 Bladder cancer - Homo sapiens (human),CHEMBL CHEMBL373882,Q02763,Tyrosine-protein kinase TIE-2,1.0,PRIMARY,NO,CNc1ncnc(n1)c2cccnc2Oc3ccc(F)c(c3)C(=O)Nc4cc(ccc4N(C)CCCN(C)C)C(F)(F)F,28,32,"InChI=1S/C29H30F4N8O2/c1-34-28-37-17-36-25(39-28)20-7-5-12-35-27(20)43-19-9-10-22(30)21(16-19)26(42)38-23-15-18(29(31,32)33)8-11-24(23)41(4)14-6-13-40(2)3/h5,7-12,15-17H,6,13-14H2,1-4H3,(H,38,42)(H,34,36,37,39)",HHKGVQGXRGQBBA-UHFFFAOYSA-N,"c(""Vascular endothelial growth factor receptor 2"", ""Tyrosine-protein kinase TIE-2"", ""Unchecked"", ""Serine/threonine-protein kinase AKT"", ""Cyclin-dependent kinase 5"", ""c-Jun N-terminal kinase 3"", ""MAP kinase p38 alpha"", ""Tyrosine-protein kinase ITK/TSK"", ""Tyrosine-protein kinase ABL"", ""Tyrosine-protein kinase SRC"", ""Tyrosine-protein kinase ZAP-70"", ""Tyrosine-protein kinase SYK"", ""Ephrin type-B receptor 4"", ""Insulin receptor"", ""Hepatocyte growth factor receptor"", ""Tyrosine-protein kinase receptor RET"", ""Platelet-derived growth factor receptor beta"", ""Macrophage colony stimulating factor receptor"", ""Nerve growth factor receptor Trk-A"", ""Epidermal growth factor receptor erbB1"", ""Insulin-like growth factor I receptor"", ""Tyrosine-protein kinase JAK3"", ""Tyrosine-protein kinase CSK"", ""Tyrosine-protein kinase LCK"", ""Tyrosine-protein kinase Lyn"", ""Tyrosine-protein kinase FGR"", ""Tyrosine-protein kinase BTK"", ""Tyrosine-protein kinase FES"", ""Serine/threonine-protein kinase Aurora-A"", ""Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)"" )",7010,TIE2,"Hemostasis R-HSA-109582 IRS-mediated signalling R-HSA-112399 SOS-mediated signalling R-HSA-112412 Signaling by ERBB2 R-HSA-1227986 Signaling by ERBB4 R-HSA-1236394 SHC1 events in ERBB2 signaling R-HSA-1250196 SHC1 events in ERBB4 signaling R-HSA-1250347 Developmental Biology R-HSA-1266738 Cytokine Signaling in Immune system R-HSA-1280215 Signaling by SCF-KIT R-HSA-1433557 Signal Transduction R-HSA-162582 Signalling by NGF R-HSA-166520 Signalling to RAS R-HSA-167044 Innate Immune System R-HSA-168249 Immune System R-HSA-168256 Prolonged ERK activation events R-HSA-169893 Frs2-mediated activation R-HSA-170968 ARMS-mediated activation R-HSA-170984 Signaling by EGFR R-HSA-177929 GRB2 events in EGFR signaling R-HSA-179812 SHC1 events in EGFR signaling R-HSA-180336 Downstream signal transduction R-HSA-186763 Signaling by PDGF R-HSA-186797 NGF signalling via TRKA from the plasma membrane R-HSA-187037 Signalling to ERKs R-HSA-187687 Signalling to p38 via RIT and RIN R-HSA-187706 Signaling by FGFR R-HSA-190236 Signaling by VEGF R-HSA-194138 GRB2 events in ERBB2 signaling R-HSA-1963640 Cell surface interactions at the vascular wall R-HSA-202733 Tie2 Signaling R-HSA-210993 DAP12 interactions R-HSA-2172127 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-2404192 DAP12 signaling R-HSA-2424491 IGF1R signaling cascade R-HSA-2428924 IRS-related events triggered by IGF1R R-HSA-2428928 Fc epsilon receptor (FCERI) signaling R-HSA-2454202 Signaling by Leptin R-HSA-2586552 FCERI mediated MAPK activation R-HSA-2871796 Signaling by GPCR R-HSA-372790 NCAM signaling for neurite out-growth R-HSA-375165 Axon guidance R-HSA-422475 VEGFA-VEGFR2 Pathway R-HSA-4420097 Signaling by Interleukins R-HSA-449147 Interleukin-2 signaling R-HSA-451927 Interleukin-3, 5 and GM-CSF signaling R-HSA-512988 VEGFR2 mediated cell proliferation R-HSA-5218921 Downstream signaling of activated FGFR1 R-HSA-5654687 FRS-mediated FGFR1 signaling R-HSA-5654693 Downstream signaling of activated FGFR2 R-HSA-5654696 FRS-mediated FGFR2 signaling R-HSA-5654700 FRS-mediated FGFR3 signaling R-HSA-5654706 Downstream signaling of activated FGFR3 R-HSA-5654708 FRS-mediated FGFR4 signaling R-HSA-5654712 Downstream signaling of activated FGFR4 R-HSA-5654716 Signaling by FGFR1 R-HSA-5654736 Signaling by FGFR2 R-HSA-5654738 Signaling by FGFR3 R-HSA-5654741 Signaling by FGFR4 R-HSA-5654743 RAF/MAP kinase cascade R-HSA-5673001 MAPK family signaling cascades R-HSA-5683057 MAPK1/MAPK3 signaling R-HSA-5684996 Insulin receptor signalling cascade R-HSA-74751 Signaling by Insulin receptor R-HSA-74752 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907 Interleukin receptor SHC signaling R-HSA-912526",stress fiber GO:0001725 18425119 IDA colocalizes_with extracellular region GO:0005576 IEA cytoplasm GO:0005737 IEA actin filament GO:0005884 18425119 IDA colocalizes_with plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 19689429 IDA microvillus GO:0005902 19424712 IDA cell-cell junction GO:0005911 18425120 IDA focal adhesion GO:0005925 IEA basal plasma membrane GO:0009925 18425120 IDA cell surface GO:0009986 19689429 IDA basolateral plasma membrane GO:0016323 19424712 IDA apical plasma membrane GO:0016324 19424712 IDA membrane raft GO:0045121 19615361 IDA,GO:0000165 MAPK cascade TAS GO:0001525 angiogenesis ISS GO:0001666 response to hypoxia IEA 15284220 GO:0001934 positive regulation of protein phosphorylation IDA 18425120 GO:0001934 positive regulation of protein phosphorylation IMP GO:0001935 endothelial cell proliferation ISS 18425120 GO:0001938 positive regulation of endothelial cell proliferation TAS GO:0001958 endochondral ossification IEA 14665640 GO:0002040 sprouting angiogenesis IMP 8382358 GO:0007165 signal transduction TAS 15284220 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IDA 8980225 GO:0007267 cell-cell signaling TAS GO:0007507 heart development ISS 15284220 GO:0010595 positive regulation of endothelial cell migration IDA 12816861 18425120 GO:0010595 positive regulation of endothelial cell migration IMP 12816861 18425120 19223473 GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IMP 18425120 GO:0016525 negative regulation of angiogenesis IMP 11513602 GO:0018108 peptidyl-tyrosine phosphorylation IDA GO:0031100 organ regeneration IEA 18425119 GO:0032878 regulation of establishment or maintenance of cell polarity IMP 18425119 GO:0034446 substrate adhesion-dependent cell spreading IMP 18366015 GO:0043066 negative regulation of apoptotic process TAS 18366015 18425120 GO:0043114 regulation of vascular permeability TAS GO:0043434 response to peptide hormone IEA GO:0043547 positive regulation of GTPase activity IEA 12816861 18425120 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IMP GO:0043627 response to estrogen IEA 15284220 GO:0045766 positive regulation of angiogenesis IDA 18425120 GO:0045766 positive regulation of angiogenesis IMP 11513602 GO:0046777 protein autophosphorylation IDA 15284220 19223473 GO:0048014 Tie signaling pathway IDA 18366015 GO:0050728 negative regulation of inflammatory response TAS GO:0050900 leukocyte migration TAS 19424712 GO:0051259 protein oligomerization IDA GO:0051591 response to cAMP IEA 18425120 GO:0051894 positive regulation of focal adhesion assembly IMP 19615361 GO:0051897 positive regulation of protein kinase B signaling IDA 18425120 GO:0051897 positive regulation of protein kinase B signaling IMP 18366015 GO:0060216 definitive hemopoiesis TAS GO:0060347 heart trabecula formation ISS 19615361 GO:0070374 positive regulation of ERK1 and ERK2 cascade IDA 18425120 GO:0070374 positive regulation of ERK1 and ERK2 cascade IMP 19223473 GO:1902533 positive regulation of intracellular signal transduction IMP 12816861 GO:2000251 positive regulation of actin cytoskeleton reorganization IMP 18425120 GO:2000351 regulation of endothelial cell apoptotic process TAS GO:2000352 negative regulation of endothelial cell apoptotic process ISS,protein kinase activity GO:0004672 TAS 8382358 protein tyrosine kinase activity GO:0004713 IDA 11513602 protein tyrosine kinase activity GO:0004713 TAS transmembrane receptor protein tyrosine kinase activity GO:0004714 IEA receptor activity GO:0004872 TAS 10766762 Ras guanyl-nucleotide exchange factor activity GO:0005088 TAS protein binding GO:0005515 IPI 8980223 19167335 19451274 19922791 20708158 ATP binding GO:0005524 IEA growth factor binding GO:0019838 IEA,Ras signaling pathway - Homo sapiens (human) hsa04014 Rap1 signaling pathway - Homo sapiens (human) hsa04015 HIF-1 signaling pathway - Homo sapiens (human) hsa04066 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04151 Rheumatoid arthritis - Homo sapiens (human) hsa05323,CHEMBL CHEMBL2387223,P29597,Tyrosine-protein kinase TYK2,1.0,PRIMARY,NO,F[C@@H]1C[C@@H]1C(=O)Nc2cc(NC(=O)c3c(F)cc(cc3Cl)C#N)ccn2,6,16,"InChI=1S/C17H11ClF2N4O2/c18-11-3-8(7-21)4-13(20)15(11)17(26)23-9-1-2-22-14(5-9)24-16(25)10-6-12(10)19/h1-5,10,12H,6H2,(H2,22,23,24,25,26)/t10-,12+/m0/s1",NKALKXMQBFLGQI-CMPLNLGQSA-N,"c(""Tyrosine-protein kinase LCK"", ""Cyclin-dependent kinase 5"", ""Unchecked"", ""Ribosomal protein S6 kinase alpha 3"", ""Ribosomal protein S6 kinase alpha 6"", ""Ribosomal protein S6 kinase alpha 2"", ""Tyrosine-protein kinase TYK2"")",7297,TYK2,R-HSA-1059683 Interleukin-6 signaling R-HSA-110056 MAPK3 (ERK1) activation R-HSA-112409 RAF-independent MAPK1/3 activation R-HSA-112411 MAPK1 (ERK2) activation R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-162582 Signal Transduction R-HSA-168256 Immune System R-HSA-449147 Signaling by Interleukins R-HSA-5683057 MAPK family signaling cascades R-HSA-5684996 MAPK1/MAPK3 signaling R-HSA-909733 Interferon alpha/beta signaling R-HSA-912694 Regulation of IFNA signaling R-HSA-913531 Interferon Signaling,nucleus 10502458 GO:0005634 IDA cytoplasm 10502458 GO:0005737 IDA cytosol GO:0005829 TAS cytoskeleton GO:0005856 IEA extrinsic component of cytoplasmic side of plasma membrane GO:0031234 IBA extracellular exosome 20458337 GO:0070062 IDA,protein phosphorylation TAS 2216457 GO:0006468 transmembrane receptor protein tyrosine kinase signaling pathway IBA GO:0007169 cell migration IBA GO:0016477 cell differentiation IBA GO:0030154 intracellular signal transduction IEA GO:0035556 peptidyl-tyrosine autophosphorylation IBA GO:0038083 regulation of cell proliferation IBA GO:0042127 innate immune response IBA GO:0045087 type I interferon signaling pathway TAS GO:0060337 regulation of type I interferon-mediated signaling pathway TAS GO:0060338,EXP 1386289 8232552 protein tyrosine kinase activity GO:0004713 TAS GO:0004713 protein tyrosine kinase activity IEA GO:0004715 non-membrane spanning protein tyrosine kinase activity IPI 10502458 growth hormone receptor binding GO:0005131 IPI 21516116 22939624 25416956 protein binding GO:0005515 IEA GO:0005524 ATP binding IEA GO:0031702 type 1 angiotensin receptor binding,hsa04380 Osteoclast differentiation - Homo sapiens (human) hsa04630 Jak-STAT signaling pathway - Homo sapiens (human) hsa05145 Toxoplasmosis - Homo sapiens (human) hsa05160 Hepatitis C - Homo sapiens (human) hsa05162 Measles - Homo sapiens (human) hsa05164 Influenza A - Homo sapiens (human) hsa05168 Herpes simplex infection - Homo sapiens (human) hsa05169 Epstein-Barr virus infection - Homo sapiens (human),CHEMBL CHEMBL1394231,Q13336,Urea transporter 1,1.0,PRIMARY,NO,CCc1ccc(cc1)S(=O)(=O)c2nnn3c4ccsc4c(NCc5cccs5)nc23,2,14,"InChI=1S/C20H17N5O2S3/c1-2-13-5-7-15(8-6-13)30(26,27)20-19-22-18(21-12-14-4-3-10-28-14)17-16(9-11-29-17)25(19)24-23-20/h3-11H,2,12H2,1H3,(H,21,22)",UYFZCWXRMHSLTC-UHFFFAOYSA-N,"c(""Microtubule-associated protein tau"", ""Unchecked"", ""Relaxin receptor 1"", ""Bromodomain adjacent to zinc finger domain protein 2B"", ""HepG2"", ""Glucagon-like peptide 1 receptor"", ""Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1"", ""Urea transporter 1"", ""Ubiquitin carboxyl-terminal hydrolase 1"")",6563,UT1,"R-HSA-382551 Transmembrane transport of small molecules R-HSA-425366 Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds R-HSA-425407 SLC-mediated transmembrane transport R-HSA-425428 Amine compound SLC transporters",GO:0005730 nucleolus IDA GO:0005886 plasma membrane TAS 19865084 GO:0005887 integral component of plasma membrane IDA GO:0016323 basolateral plasma membrane IEA GO:0043231 intracellular membrane-bounded organelle IDA,GO:0006833 water transport IEA GO:0015840 urea transport 7989337 TAS GO:0055085 transmembrane transport TAS GO:0071918 urea transmembrane transport 19865084 IDA,IEA GO:0005372 water transmembrane transporter activity TAS GO:0015204 urea transmembrane transporter activity 19865084 IDA GO:0015265 urea channel activity,,CHEMBL CHEMBL294199,Q8NER1,Vanilloid receptor,1.0,PRIMARY,YES,COc1cc(CNC(=O)CCCC\C=C\C(C)C)ccc1O,7,76,"InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+",YKPUWZUDDOIDPM-SOFGYWHQSA-N,"c(""Tyrosyl-tRNA synthetase"", ""Vanilloid receptor"", ""Cyclooxygenase-1"", ""Cannabinoid CB1 receptor"", ""Cannabinoid CB2 receptor"", ""Menin/Histone-lysine N-methyltransferase MLL"", ""Prelamin-A/C"", ""Endoplasmic reticulum-associated amyloid beta-peptide-binding protein"", ""Survival motor neuron protein"", ""Microtubule-associated protein tau"", ""Aldehyde dehydrogenase 1A1"", ""Arachidonate 15-lipoxygenase"", ""MAP kinase ERK2"", ""Lymphoblastoid cells"", ""Unchecked"", ""Beta-glucocerebrosidase"", ""Runt-related transcription factor 1/Core-binding factor subunit beta"", ""Androgen Receptor"", ""Chromobox protein homolog 1"", ""DNA polymerase iota"", ""Peroxisome proliferator-activated receptor gamma"", ""Nuclear factor erythroid 2-related factor 2"", ""Glutaminase kidney isoform, mitochondrial"", ""Nuclear receptor ROR-gamma"", ""Peroxisome proliferator-activated receptor delta"", ""DNA-(apurinic or apyrimidinic site) lyase"", ""Transthyretin"")",7442,TRPV1,Stimuli-sensing channels R-HSA-2672351 TRP channels R-HSA-3295583 Transmembrane transport of small molecules R-HSA-382551 Ion channel transport R-HSA-983712,intracellular IEA GO:0005622 plasma membrane TAS GO:0005886 integral component of plasma membrane TAS 9349813 GO:0005887 integral component of membrane IDA 123456 GO:0016021 cell junction IEA GO:0030054 intrinsic component of plasma membrane ISS GO:0031226 dendritic spine membrane IEA GO:0032591 postsynaptic membrane ISS GO:0045211,transport GO:0006810 TAS 9349813 cell surface receptor signaling pathway GO:0007166 TAS 9349813 chemosensory behavior GO:0007635 TAS 9349813 thermoception GO:0050955 IDA 123456 release of sequestered calcium ion into cytosol GO:0051209 IEA calcium ion transmembrane transport GO:0070588 ISS calcium ion transmembrane transport GO:0070588 TAS cellular response to alkaloid GO:0071312 ISS cellular response to ATP GO:0071318 ISS,transmembrane signaling receptor activity GO:0004888 ISS excitatory extracellular ligand-gated ion channel activity GO:0005231 ISS calcium channel activity GO:0005262 TAS calmodulin binding GO:0005516 IEA ATP binding GO:0005524 ISS calcium-release channel activity GO:0015278 ISS phosphoprotein binding GO:0051219 19801576 IPI,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Inflammatory mediator regulation of TRP channels - Homo sapiens (human) hsa04750,CHEMBL CHEMBL347537,P35968,Vascular endothelial growth factor receptor 2,1.0,PRIMARY,NO,O=C(Nc1cccc(c1)c2cncc3ccccc23)c4ccccc4NCc5ccncc5,14,16,"InChI=1S/C28H22N4O/c33-28(25-10-3-4-11-27(25)31-17-20-12-14-29-15-13-20)32-23-8-5-7-21(16-23)26-19-30-18-22-6-1-2-9-24(22)26/h1-16,18-19,31H,17H2,(H,32,33)",IGMQBINYIPIDJQ-UHFFFAOYSA-N,"c(""Vascular endothelial growth factor receptor 1"", ""Vascular endothelial growth factor receptor 2"", ""Vascular endothelial growth factor receptor 3"", ""Platelet-derived growth factor receptor beta"", ""Stem cell growth factor receptor"", ""Macrophage colony stimulating factor receptor"", ""Fibroblast growth factor receptor 1"", ""Epidermal growth factor receptor erbB1"", ""Cyclin-dependent kinase 1"", ""Tyrosine-protein kinase TIE-2"", ""Macrophage-stimulating protein receptor"", ""Insulin-like growth factor I receptor"", ""Tyrosine-protein kinase SRC"", ""Tyrosine-protein kinase ABL"", ""Unchecked"")",3791,VGFR2,R-HSA-1266738 Developmental Biology R-HSA-1474244 Extracellular matrix organization R-HSA-162582 Signal Transduction R-HSA-194138 Signaling by VEGF R-HSA-194306 Neurophilin interactions with VEGF and VEGFR R-HSA-194313 VEGF ligand-receptor interactions R-HSA-195399 VEGF binds to VEGFR leading to receptor dimerization R-HSA-216083 Integrin cell surface interactions R-HSA-2682334 EPH-Ephrin signaling R-HSA-3928663 EPHA-mediated growth cone collapse R-HSA-422475 Axon guidance R-HSA-4420097 VEGFA-VEGFR2 Pathway R-HSA-5218921 VEGFR2 mediated cell proliferation,"GO:0005576 extracellular region IEA GO:0005634 nucleus IEA GO:0005768 endosome 23262137 IDA GO:0005769 early endosome ISS GO:0005783 endoplasmic reticulum 23529610 IDA GO:0005794 Golgi apparatus 23262137 IDA GO:0005886 plasma membrane 23262137 IDA GO:0005886 plasma membrane ISS GO:0005886 plasma membrane TAS GO:0005887 integral component of plasma membrane 10102632 IDA GO:0016023 cytoplasmic, membrane-bounded vesicle IEA GO:0030054 cell junction ISS GO:0045121 membrane raft 23262137 IDA GO:0097443 sorting endosome ISS",TAS 10022831 angiogenesis GO:0001525 ISS GO:0001570 vasculogenesis IDA 19033661 positive regulation of protein phosphorylation GO:0001934 IMP 10022831 11387210 positive regulation of endothelial cell proliferation GO:0001938 ISS GO:0002042 cell migration involved in sprouting angiogenesis ISS GO:0003158 endothelium development TAS 1417831 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 IDA 7929439 positive regulation of cell proliferation GO:0008284 IMP 15215251 positive regulation of cell proliferation GO:0008284 IDA 7929439 regulation of cell shape GO:0008360 IMP 10022831 positive regulation of endothelial cell migration GO:0010595 IDA 9804796 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 IEA GO:0016032 viral process IGI 23798385 positive regulation of macroautophagy GO:0016239 IDA 10037737 10102632 peptidyl-tyrosine phosphorylation GO:0018108 IEA GO:0023014 signal transduction by protein phosphorylation TAS GO:0030198 extracellular matrix organization IDA 7929439 positive regulation of cell migration GO:0030335 IMP 15215251 positive regulation of cell migration GO:0030335 ISS GO:0035162 embryonic hemopoiesis IMP 15215251 calcium-mediated signaling using intracellular calcium source GO:0035584 IDA 10102632 11387210 19033661 23529610 cellular response to vascular endothelial growth factor stimulus GO:0035924 IMP 15215251 cellular response to vascular endothelial growth factor stimulus GO:0035924 IDA 21885851 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway GO:0038033 ISS GO:0038083 peptidyl-tyrosine autophosphorylation IMP 15215251 negative regulation of apoptotic process GO:0043066 IDA 11387210 positive regulation of MAPK cascade GO:0043410 IMP 15215251 positive regulation of angiogenesis GO:0045766 IDA 10037737 10102632 19033661 protein autophosphorylation GO:0046777 IDA 10102632 11387210 15215251 vascular endothelial growth factor receptor signaling pathway GO:0048010 IMP 23529610 vascular endothelial growth factor receptor signaling pathway GO:0048010 TAS GO:0048010 vascular endothelial growth factor receptor signaling pathway IDA 7929439 positive regulation of positive chemotaxis GO:0050927 IDA 10600473 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 IMP 9837777 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 IDA 12820653 positive regulation of focal adhesion assembly GO:0051894 IGI 23798385 positive regulation of mitochondrial depolarization GO:0051901 IMP 15215251 positive regulation of ERK1 and ERK2 cascade GO:0070374 IGI 23798385 positive regulation of mitochondrial fission GO:0090141 IDA 9804796 negative regulation of endothelial cell apoptotic process GO:2000352 ISS GO:2001214 positive regulation of vasculogenesis,protein tyrosine kinase activity 7999104 9398617 10037737 15962004 GO:0004713 EXP protein tyrosine kinase activity 10037737 GO:0004713 IDA transmembrane receptor protein tyrosine kinase activity 1417831 GO:0004714 TAS receptor signaling protein tyrosine kinase activity 10022831 GO:0004716 TAS vascular endothelial growth factor-activated receptor activity 1417831 10022831 10102632 11387210 15215251 GO:0005021 IDA integrin binding 10022831 GO:0005178 IPI protein binding 1417831 16530705 16763549 16966330 17222790 18377662 18662404 18936167 19033661 20224550 20660291 21130043 21596751 21893193 22789536 22897854 23374253 23397142 23529610 23583373 24529377 GO:0005515 IPI ATP binding GO:0005524 IEA growth factor binding 1417831 10022831 GO:0019838 IPI Hsp90 protein binding 19267251 GO:0051879 TAS,hsa04014 Ras signaling pathway - Homo sapiens (human) hsa04015 Rap1 signaling pathway - Homo sapiens (human) hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human) hsa04144 Endocytosis - Homo sapiens (human) hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human) hsa04370 VEGF signaling pathway - Homo sapiens (human) hsa04510 Focal adhesion - Homo sapiens (human) hsa05205 Proteoglycans in cancer - Homo sapiens (human),CHEMBL CHEMBL3416861,P37288,Vasopressin V1a receptor,1.0,ORTHOGONAL,NO,Clc1ccc2c(c[nH]c2c1)C(=O)N3CCC4(CC3)OCc5ccccc45,3,6,"InChI=1S/C21H19ClN2O2/c22-15-5-6-16-17(12-23-19(16)11-15)20(25)24-9-7-21(8-10-24)18-4-2-1-3-14(18)13-26-21/h1-6,11-12,23H,7-10,13H2",FPWHCHLKTSMBLA-UHFFFAOYSA-N,"c(""Unchecked"", ""Oxytocin receptor"", ""Vasopressin V2 receptor"", ""Vasopressin V1a receptor"")",552,V1AR,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 Vasopressin-like receptors R-HSA-388479 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,endosome GO:0005768 TAS 10858434 cytosol GO:0005829 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 TAS 8838314 cytoplasmic vesicle GO:0031410 IEA,IBA GO:0001992 regulation of systemic arterial blood pressure by vasopressin IEA GO:0002125 maternal aggressive behavior IEA GO:0003084 positive regulation of systemic arterial blood pressure 8106369 TAS GO:0006091 generation of precursor metabolites and energy IEA GO:0007186 G-protein coupled receptor signaling pathway 8106369 TAS GO:0007202 activation of phospholipase C activity IEA GO:0007204 positive regulation of cytosolic calcium ion concentration IEA GO:0007621 negative regulation of female receptivity IEA GO:0007625 grooming behavior 8106369 TAS GO:0008015 blood circulation IEA GO:0008284 positive regulation of cell proliferation IEA GO:0010460 positive regulation of heart rate IEA GO:0014049 positive regulation of glutamate secretion IEA GO:0014902 myotube differentiation IEA GO:0019722 calcium-mediated signaling IEA GO:0021537 telencephalon development IEA GO:0030307 positive regulation of cell growth IEA GO:0031394 positive regulation of prostaglandin biosynthetic process IEA GO:0032849 positive regulation of cellular pH reduction IBA GO:0032870 cellular response to hormone stimulus IEA GO:0035176 social behavior IEA GO:0035815 positive regulation of renal sodium excretion IEA GO:0042631 cellular response to water deprivation IBA GO:0042711 maternal behavior IEA GO:0042713 sperm ejaculation IEA GO:0043084 penile erection IBA GO:0045907 positive regulation of vasoconstriction IEA GO:0051412 response to corticosterone IEA GO:0051970 negative regulation of transmission of nerve impulse IBA GO:1901652 response to peptide,GO:0005000 vasopressin receptor activity IEA 10858434 GO:0005080 protein kinase C binding TAS 18402937 GO:0005515 protein binding IPI GO:0017046 peptide hormone binding IEA GO:0031894 V1A vasopressin receptor binding IEA GO:0042277 peptide binding IBA,Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Vascular smooth muscle contraction - Homo sapiens (human) hsa04270,CHEMBL CHEMBL1774023,P37288,Vasopressin V1a receptor,1.0,PRIMARY,NO,Clc1ccc(C[C@@H](NC(=O)Cc2ccc(Cl)cc2)C(=O)N[C@H]3C[C@H]4CC[C@@H](C3)N4)cc1,4,6,"InChI=1S/C24H27Cl2N3O2/c25-17-5-1-15(2-6-17)11-22(29-23(30)12-16-3-7-18(26)8-4-16)24(31)28-21-13-19-9-10-20(14-21)27-19/h1-8,19-22,27H,9-14H2,(H,28,31)(H,29,30)/t19-,20+,21+,22-/m1/s1",VYUFUXRLJDFDIC-CLAROIROSA-N,"c(""Vasopressin V1a receptor"", ""Vasopressin V1b receptor"", ""Vasopressin V2 receptor"", ""Oxytocin receptor"")",552,V1AR,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 Vasopressin-like receptors R-HSA-388479 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,endosome GO:0005768 TAS 10858434 cytosol GO:0005829 IEA plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 TAS 8838314 cytoplasmic vesicle GO:0031410 IEA,IBA GO:0001992 regulation of systemic arterial blood pressure by vasopressin IEA GO:0002125 maternal aggressive behavior IEA GO:0003084 positive regulation of systemic arterial blood pressure 8106369 TAS GO:0006091 generation of precursor metabolites and energy IEA GO:0007186 G-protein coupled receptor signaling pathway 8106369 TAS GO:0007202 activation of phospholipase C activity IEA GO:0007204 positive regulation of cytosolic calcium ion concentration IEA GO:0007621 negative regulation of female receptivity IEA GO:0007625 grooming behavior 8106369 TAS GO:0008015 blood circulation IEA GO:0008284 positive regulation of cell proliferation IEA GO:0010460 positive regulation of heart rate IEA GO:0014049 positive regulation of glutamate secretion IEA GO:0014902 myotube differentiation IEA GO:0019722 calcium-mediated signaling IEA GO:0021537 telencephalon development IEA GO:0030307 positive regulation of cell growth IEA GO:0031394 positive regulation of prostaglandin biosynthetic process IEA GO:0032849 positive regulation of cellular pH reduction IBA GO:0032870 cellular response to hormone stimulus IEA GO:0035176 social behavior IEA GO:0035815 positive regulation of renal sodium excretion IEA GO:0042631 cellular response to water deprivation IBA GO:0042711 maternal behavior IEA GO:0042713 sperm ejaculation IEA GO:0043084 penile erection IBA GO:0045907 positive regulation of vasoconstriction IEA GO:0051412 response to corticosterone IEA GO:0051970 negative regulation of transmission of nerve impulse IBA GO:1901652 response to peptide,GO:0005000 vasopressin receptor activity IEA 10858434 GO:0005080 protein kinase C binding TAS 18402937 GO:0005515 protein binding IPI GO:0017046 peptide hormone binding IEA GO:0031894 V1A vasopressin receptor binding IEA GO:0042277 peptide binding IBA,Calcium signaling pathway - Homo sapiens (human) hsa04020 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Vascular smooth muscle contraction - Homo sapiens (human) hsa04270,CHEMBL CHEMBL1684573,P47901,Vasopressin V1b receptor,1.0,ORTHOGONAL,NO,COc1cccc(c1)C2=Nc3ccc(OCCCN4CCCCC4)cc3C(=O)N2CC(=O)NC(C)C,4,5,"InChI=1S/C28H36N4O4/c1-20(2)29-26(33)19-32-27(21-9-7-10-22(17-21)35-3)30-25-12-11-23(18-24(25)28(32)34)36-16-8-15-31-13-5-4-6-14-31/h7,9-12,17-18,20H,4-6,8,13-16,19H2,1-3H3,(H,29,33)",NQOZPTYIJQUKTJ-UHFFFAOYSA-N,"c(""Vasopressin V1b receptor"", ""Vasopressin V1a receptor"", ""Vasopressin V2 receptor"", ""Oxytocin receptor"")",553,V1BR,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 Vasopressin-like receptors R-HSA-388479 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,TAS 10858434 endosome GO:0005768 TAS GO:0005886 plasma membrane TAS 7805841 integral component of plasma membrane GO:0005887,regulation of systemic arterial blood pressure by vasopressin GO:0001992 IBA G-protein coupled receptor signaling pathway GO:0007186 IEA activation of phospholipase C activity GO:0007202 7805841 TAS positive regulation of cytosolic calcium ion concentration GO:0007204 7929452 TAS cellular response to hormone stimulus GO:0032870 IBA positive regulation of vasoconstriction GO:0045907 IBA response to peptide GO:1901652 IBA,vasopressin receptor activity IEA GO:0005000 protein kinase C binding TAS 10858434 GO:0005080 peptide binding IBA GO:0042277,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04270 Vascular smooth muscle contraction - Homo sapiens (human),CHEMBL CHEMBL1765669,P47901,Vasopressin V1b receptor,1.0,PRIMARY,NO,CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)C(O)CSSC[C@H](NC(=O)[C@H](CC(=O)N)NC1=O)C(=O)N4CCC[C@H]4C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)O,4,7,"InChI=1S/C47H66N10O13S2/c1-26(2)19-31-41(64)54-34(22-38(49)60)44(67)56-35(47(70)57-18-8-12-36(57)45(68)51-30(11-6-7-17-48)40(63)50-23-39(61)62)24-71-72-25-37(59)46(69)55-33(21-28-13-15-29(58)16-14-28)43(66)53-32(42(65)52-31)20-27-9-4-3-5-10-27/h3-5,9-10,13-16,26,30-37,58-59H,6-8,11-12,17-25,48H2,1-2H3,(H2,49,60)(H,50,63)(H,51,68)(H,52,65)(H,53,66)(H,54,64)(H,55,69)(H,56,67)(H,61,62)/t30-,31-,32-,33-,34-,35-,36-,37?/m0/s1",RCKPKSSQWGXFSM-GOCTXPOLSA-N,"c(""Vasopressin V1a receptor"", ""Vasopressin V1b receptor"", ""Vasopressin V2 receptor"", ""Oxytocin receptor"", ""Unchecked"")",553,V1BR,Signal Transduction R-HSA-162582 Signaling by GPCR R-HSA-372790 Class A/1 (Rhodopsin-like receptors) R-HSA-373076 Peptide ligand-binding receptors R-HSA-375276 GPCR downstream signaling R-HSA-388396 Vasopressin-like receptors R-HSA-388479 G alpha (q) signalling events R-HSA-416476 GPCR ligand binding R-HSA-500792 Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-881907,TAS 10858434 endosome GO:0005768 TAS GO:0005886 plasma membrane TAS 7805841 integral component of plasma membrane GO:0005887,regulation of systemic arterial blood pressure by vasopressin GO:0001992 IBA G-protein coupled receptor signaling pathway GO:0007186 IEA activation of phospholipase C activity GO:0007202 7805841 TAS positive regulation of cytosolic calcium ion concentration GO:0007204 7929452 TAS cellular response to hormone stimulus GO:0032870 IBA positive regulation of vasoconstriction GO:0045907 IBA response to peptide GO:1901652 IBA,vasopressin receptor activity IEA GO:0005000 protein kinase C binding TAS 10858434 GO:0005080 peptide binding IBA GO:0042277,hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04270 Vascular smooth muscle contraction - Homo sapiens (human),CHEMBL CHEMBL2172288,P30518,Vasopressin V2 receptor,1.0,ORTHOGONAL,NO,OC(=O)c1cc(NC(=S)NCCOCCOCCOCCn2cc(CNC(=O)CCC(=O)NC3CCCN(C(=O)c4ccc(NC(=O)c5ccccc5c6ccccc6)cc4)c7ccccc37)nn2)ccc1C8=C9C=CC(=O)C=C9Oc%10cc(O)ccc8%10,4,9,"InChI=1S/C66H63N9O12S/c76-47-21-24-53-58(38-47)87-59-39-48(77)22-25-54(59)62(53)50-23-20-45(37-55(50)65(82)83)70-66(88)67-28-31-84-33-35-86-36-34-85-32-30-74-41-46(72-73-74)40-68-60(78)26-27-61(79)71-56-14-8-29-75(57-15-7-6-13-52(56)57)64(81)43-16-18-44(19-17-43)69-63(80)51-12-5-4-11-49(51)42-9-2-1-3-10-42/h1-7,9-13,15-25,37-39,41,56,76H,8,14,26-36,40H2,(H,68,78)(H,69,80)(H,71,79)(H,82,83)(H2,67,70,88)",BHGIBKQRMXLQED-UHFFFAOYSA-N,"c(""Vasopressin V2 receptor"", ""Unchecked"", ""Oxytocin receptor"", ""Vasopressin V1b receptor"", ""Vasopressin V1a receptor"")",554,V2R,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-382551 Transmembrane transport of small molecules R-HSA-388396 GPCR downstream signaling R-HSA-388479 Vasopressin-like receptors R-HSA-418555 G alpha (s) signalling events R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-445717 Aquaporin-mediated transport R-HSA-500792 GPCR ligand binding,10858434 TAS GO:0005768 endosome 10880054 TAS GO:0005783 endoplasmic reticulum 10880054 TAS GO:0005794 Golgi apparatus TAS GO:0005886 plasma membrane 1303257 TAS GO:0005887 integral component of plasma membrane 8882880 NAS GO:0016021 integral component of membrane,regulation of systemic arterial blood pressure by vasopressin GO:0001992 IBA positive regulation of systemic arterial blood pressure GO:0003084 IEA renal water homeostasis GO:0003091 TAS adenylate cyclase-modulating G-protein coupled receptor signaling pathway 10880054 GO:0007188 TAS activation of adenylate cyclase activity 9224808 GO:0007190 TAS I-kappaB kinase/NF-kappaB signaling GO:0007249 IEA excretion 1303257 GO:0007588 TAS hemostasis 10880054 GO:0007599 TAS positive regulation of cell proliferation GO:0008284 IEA positive regulation of gene expression GO:0010628 ISS telencephalon development GO:0021537 IEA positive regulation of protein ubiquitination 19372219 GO:0031398 NAS interferon-gamma production GO:0032609 IEA cellular response to hormone stimulus GO:0032870 IBA response to cytokine GO:0034097 IEA negative regulation of urine volume GO:0035811 IEA negative regulation of renal sodium excretion GO:0035814 IEA positive regulation of vasoconstriction GO:0045907 IBA response to peptide GO:1901652 IBA,GO:0005000 vasopressin receptor activity 8882880 TAS GO:0005515 protein binding 12409230 23236378 IPI GO:0042277 peptide binding IBA,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Vasopressin-regulated water reabsorption - Homo sapiens (human) hsa04962,CHEMBL CHEMBL2172289,P30518,Vasopressin V2 receptor,1.0,PRIMARY,NO,CCN1\C(=C\C=C\C=C\C2=[N+](CC)c3ccc(cc3C2(C)C)S(=O)(=O)[O-])\C(C)(CCCC(=O)NCCn4cc(CNC(=O)CCC(=O)NC5CCCN(C(=O)c6ccc(NC(=O)c7ccccc7c8ccccc8)cc6)c9ccccc59)nn4)c%10cc(ccc1%10)S(=O)(=O)O,4,9,"InChI=1S/C71H76N10O11S2/c1-6-79-61-36-34-52(93(87,88)89)44-57(61)70(3,4)63(79)27-12-9-13-28-64-71(5,58-45-53(94(90,91)92)35-37-62(58)80(64)7-2)40-18-29-65(82)72-41-43-78-47-51(76-77-78)46-73-66(83)38-39-67(84)75-59-25-19-42-81(60-26-17-16-24-56(59)60)69(86)49-30-32-50(33-31-49)74-68(85)55-23-15-14-22-54(55)48-20-10-8-11-21-48/h8-17,20-24,26-28,30-37,44-45,47,59H,6-7,18-19,25,29,38-43,46H2,1-5H3,(H5-,72,73,74,75,82,83,84,85,86,87,88,89,90,91,92)",JLDUHYJPNRGFMT-UHFFFAOYSA-N,"c(""Vasopressin V2 receptor"", ""Unchecked"", ""Oxytocin receptor"", ""Vasopressin V1b receptor"", ""Vasopressin V1a receptor"")",554,V2R,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-382551 Transmembrane transport of small molecules R-HSA-388396 GPCR downstream signaling R-HSA-388479 Vasopressin-like receptors R-HSA-418555 G alpha (s) signalling events R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-445717 Aquaporin-mediated transport R-HSA-500792 GPCR ligand binding,10858434 TAS GO:0005768 endosome 10880054 TAS GO:0005783 endoplasmic reticulum 10880054 TAS GO:0005794 Golgi apparatus TAS GO:0005886 plasma membrane 1303257 TAS GO:0005887 integral component of plasma membrane 8882880 NAS GO:0016021 integral component of membrane,regulation of systemic arterial blood pressure by vasopressin GO:0001992 IBA positive regulation of systemic arterial blood pressure GO:0003084 IEA renal water homeostasis GO:0003091 TAS adenylate cyclase-modulating G-protein coupled receptor signaling pathway 10880054 GO:0007188 TAS activation of adenylate cyclase activity 9224808 GO:0007190 TAS I-kappaB kinase/NF-kappaB signaling GO:0007249 IEA excretion 1303257 GO:0007588 TAS hemostasis 10880054 GO:0007599 TAS positive regulation of cell proliferation GO:0008284 IEA positive regulation of gene expression GO:0010628 ISS telencephalon development GO:0021537 IEA positive regulation of protein ubiquitination 19372219 GO:0031398 NAS interferon-gamma production GO:0032609 IEA cellular response to hormone stimulus GO:0032870 IBA response to cytokine GO:0034097 IEA negative regulation of urine volume GO:0035811 IEA negative regulation of renal sodium excretion GO:0035814 IEA positive regulation of vasoconstriction GO:0045907 IBA response to peptide GO:1901652 IBA,GO:0005000 vasopressin receptor activity 8882880 TAS GO:0005515 protein binding 12409230 23236378 IPI GO:0042277 peptide binding IBA,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Vasopressin-regulated water reabsorption - Homo sapiens (human) hsa04962,CHEMBL CHEMBL363910,P30518,Vasopressin V2 receptor,1.0,PRIMARY,YES,Cc1ccn(n1)c2ccc(C(=O)N3Cc4cccn4Cc5ccccc35)c(Cl)c2,3,18,"InChI=1S/C23H19ClN4O/c1-16-10-12-28(25-16)18-8-9-20(21(24)13-18)23(29)27-15-19-6-4-11-26(19)14-17-5-2-3-7-22(17)27/h2-13H,14-15H2,1H3",JXKQHDZUZGKDGO-UHFFFAOYSA-N,"c(""Unchecked"", ""Vasopressin V2 receptor"", ""Vasopressin V1a receptor"", ""Oxytocin receptor"")",554,V2R,R-HSA-162582 Signal Transduction R-HSA-372790 Signaling by GPCR R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-375276 Peptide ligand-binding receptors R-HSA-382551 Transmembrane transport of small molecules R-HSA-388396 GPCR downstream signaling R-HSA-388479 Vasopressin-like receptors R-HSA-418555 G alpha (s) signalling events R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-445717 Aquaporin-mediated transport R-HSA-500792 GPCR ligand binding,10858434 TAS GO:0005768 endosome 10880054 TAS GO:0005783 endoplasmic reticulum 10880054 TAS GO:0005794 Golgi apparatus TAS GO:0005886 plasma membrane 1303257 TAS GO:0005887 integral component of plasma membrane 8882880 NAS GO:0016021 integral component of membrane,regulation of systemic arterial blood pressure by vasopressin GO:0001992 IBA positive regulation of systemic arterial blood pressure GO:0003084 IEA renal water homeostasis GO:0003091 TAS adenylate cyclase-modulating G-protein coupled receptor signaling pathway 10880054 GO:0007188 TAS activation of adenylate cyclase activity 9224808 GO:0007190 TAS I-kappaB kinase/NF-kappaB signaling GO:0007249 IEA excretion 1303257 GO:0007588 TAS hemostasis 10880054 GO:0007599 TAS positive regulation of cell proliferation GO:0008284 IEA positive regulation of gene expression GO:0010628 ISS telencephalon development GO:0021537 IEA positive regulation of protein ubiquitination 19372219 GO:0031398 NAS interferon-gamma production GO:0032609 IEA cellular response to hormone stimulus GO:0032870 IBA response to cytokine GO:0034097 IEA negative regulation of urine volume GO:0035811 IEA negative regulation of renal sodium excretion GO:0035814 IEA positive regulation of vasoconstriction GO:0045907 IBA response to peptide GO:1901652 IBA,GO:0005000 vasopressin receptor activity 8882880 TAS GO:0005515 protein binding 12409230 23236378 IPI GO:0042277 peptide binding IBA,Neuroactive ligand-receptor interaction - Homo sapiens (human) hsa04080 Vasopressin-regulated water reabsorption - Homo sapiens (human) hsa04962,CHEMBL CHEMBL129530,Q16572,Vesicular acetylcholine transporter,1.0,PRIMARY,NO,O[C@@H]1CCN(Cc2ccc(F)cc2)C[C@H]1N3CCC(CC3)c4ccccc4,2,10,"InChI=1S/C23H29FN2O/c24-21-8-6-18(7-9-21)16-25-13-12-23(27)22(17-25)26-14-10-20(11-15-26)19-4-2-1-3-5-19/h1-9,20,22-23,27H,10-17H2/t22-,23-/m1/s1",HPZHSYBCGLDRCT-DHIUTWEWSA-N,"c(""Vesicular acetylcholine transporter"", ""Unchecked"", ""Sigma opioid receptor"")",6572,VACHT,Neurotransmitter Release Cycle R-HSA-112310 Transmission across Chemical Synapses R-HSA-112315 Neuronal System R-HSA-112316 Acetylcholine Neurotransmitter Release Cycle R-HSA-264642,plasma membrane GO:0005886 TAS integral component of plasma membrane GO:0005887 8071310 TAS membrane GO:0016020 8071310 TAS clathrin-sculpted acetylcholine transport vesicle membrane GO:0060201 TAS presynapse GO:0098793 IEA,GO:0007269 neurotransmitter secretion TAS 8071310 GO:0015870 acetylcholine transport TAS GO:0072488 ammonium transmembrane transport IEA,acetylcholine transmembrane transporter activity GO:0005277 TAS,hsa04721 Synaptic vesicle cycle - Homo sapiens (human) hsa04725 Cholinergic synapse - Homo sapiens (human),CHEMBL CHEMBL3609092,P22001,Voltage-gated potassium channel subunit Kv1.3,1.0,ORTHOGONAL,NO,CC[C@H](C)[C@@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc5ccccc5)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc6ccc(O)cc6)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc7cnc[nH]7)NC(=O)[C@H](CCCCN)NC3=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N2)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]8CCCN8C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC1=O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CCCNC(=N)N,2,5,"InChI=1S/C174H286N56O48S6/c1-13-88(5)130-164(271)213-116(73-129(241)242)153(260)228-135(95(12)238)168(275)226-131(89(6)14-2)169(276)230-67-37-52-127(230)163(270)207-106(47-25-31-61-179)144(251)215-118(77-232)154(261)204-110(51-36-66-194-174(188)189)146(253)219-126-85-284-282-83-124-160(267)206-108(49-34-64-192-172(184)185)140(247)200-107(48-26-32-62-180)147(254)227-134(94(11)237)167(274)222-121(138(245)195-75-128(240)224-132(92(9)235)166(273)223-122(158(265)198-91(8)170(277)278)81-280-283-84-125(161(268)225-130)221-157(264)117(76-231)214-137(244)101(181)42-33-63-191-171(182)183)80-279-281-82-123(218-145(252)105(46-24-30-60-178)201-149(256)112(69-96-38-17-15-18-39-96)208-136(243)90(7)197-165(272)133(93(10)236)229-162(126)269)159(266)205-104(45-23-29-59-177)142(249)212-115(72-99-74-190-86-196-99)152(259)217-119(78-233)155(262)203-102(43-21-27-57-175)139(246)199-103(44-22-28-58-176)141(248)210-114(71-98-53-55-100(239)56-54-98)150(257)202-109(50-35-65-193-173(186)187)143(250)209-111(68-87(3)4)148(255)216-120(79-234)156(263)211-113(151(258)220-124)70-97-40-19-16-20-41-97/h15-20,38-41,53-56,74,86-95,101-127,130-135,231-239H,13-14,21-37,42-52,57-73,75-85,175-181H2,1-12H3,(H,190,196)(H,195,245)(H,197,272)(H,198,265)(H,199,246)(H,200,247)(H,201,256)(H,202,257)(H,203,262)(H,204,261)(H,205,266)(H,206,267)(H,207,270)(H,208,243)(H,209,250)(H,210,248)(H,211,263)(H,212,249)(H,213,271)(H,214,244)(H,215,251)(H,216,255)(H,217,259)(H,218,252)(H,219,253)(H,220,258)(H,221,264)(H,222,274)(H,223,273)(H,224,240)(H,225,268)(H,226,275)(H,227,254)(H,228,260)(H,229,269)(H,241,242)(H,277,278)(H4,182,183,191)(H4,184,185,192)(H4,186,187,193)(H4,188,189,194)/t88-,89-,90-,91-,92+,93+,94+,95+,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,130-,131-,132-,133-,134-,135-/m0/s1",SYGMFDWVXIFOBU-CVHNOKNFSA-N,"c(""Voltage-gated potassium channel subunit Kv1.3"", ""Voltage-gated potassium channel subunit Kv1.1"", ""Unchecked"")",3738,KCNA3,R-HSA-112316 Neuronal System R-HSA-1296071 Potassium Channels R-HSA-1296072 Voltage gated Potassium channels,plasma membrane GO:0005886 TAS voltage-gated potassium channel complex GO:0008076 IEA axon GO:0030424 IEA membrane raft GO:0045121 IEA,potassium ion transport TAS 1373731 GO:0006813 regulation of ion transmembrane transport IEA GO:0034765 protein homooligomerization IEA GO:0051260 potassium ion transmembrane transport IEA GO:0071805,TAS 1373731 voltage-gated ion channel activity GO:0005244 IBA GO:0005251 delayed rectifier potassium channel activity IEA GO:0015271 outward rectifier potassium channel activity,,CHEMBL CHEMBL378104,P22001,Voltage-gated potassium channel subunit Kv1.3,1.0,PRIMARY,NO,COc1cc(O)cc(O)c1C(=O)\C=C\c2ccccc2,2,53,"InChI=1S/C16H14O4/c1-20-15-10-12(17)9-14(19)16(15)13(18)8-7-11-5-3-2-4-6-11/h2-10,17,19H,1H3/b8-7+",NYSZJNUIVUBQMM-BQYQJAHWSA-N,"c(""Unchecked"", ""PANC-1"", ""DLD-1"", ""AGS"", ""Voltage-gated potassium channel subunit Kv1.3"", ""Microtubule-associated protein tau"", ""Menin/Histone-lysine N-methyltransferase MLL"", ""Neuropeptide S receptor"", ""Lysine-specific demethylase 4A"", ""Bromodomain adjacent to zinc finger domain protein 2B"", ""DNA polymerase iota"", ""Mothers against decapentaplegic homolog 3"", ""Geminin"", ""DNA dC->dU-editing enzyme APOBEC-3G"", ""Ataxin-2"", ""Parathyroid hormone receptor"", ""Guanine nucleotide-binding protein G(s), subunit alpha"", ""Rap guanine nucleotide exchange factor 3"", ""HCT-116"")",3738,KCNA3,R-HSA-112316 Neuronal System R-HSA-1296071 Potassium Channels R-HSA-1296072 Voltage gated Potassium channels,plasma membrane GO:0005886 TAS voltage-gated potassium channel complex GO:0008076 IEA axon GO:0030424 IEA membrane raft GO:0045121 IEA,potassium ion transport TAS 1373731 GO:0006813 regulation of ion transmembrane transport IEA GO:0034765 protein homooligomerization IEA GO:0051260 potassium ion transmembrane transport IEA GO:0071805,TAS 1373731 voltage-gated ion channel activity GO:0005244 IBA GO:0005251 delayed rectifier potassium channel activity IEA GO:0015271 outward rectifier potassium channel activity,,CHEMBL CHEMBL3115194,O43497,Voltage-gated T-type calcium channel alpha-1G subunit,1.0,PRIMARY,NO,COC(=O)C(CCC(=O)N(C)CCCc1nc2ccccc2[nH]1)(C(C)C)c3ccc(Br)cc3,2,4,"InChI=1S/C26H32BrN3O3/c1-18(2)26(25(32)33-4,19-11-13-20(27)14-12-19)16-15-24(31)30(3)17-7-10-23-28-21-8-5-6-9-22(21)29-23/h5-6,8-9,11-14,18H,7,10,15-17H2,1-4H3,(H,28,29)",GLOKEGVIMFVYSX-UHFFFAOYSA-N,"c(""Unchecked"", ""Voltage-gated L-type calcium channel alpha-1C subunit"", ""Voltage-gated T-type calcium channel alpha-1G subunit"")",8913,CAC1G,R-HSA-1266738 Developmental Biology R-HSA-375165 NCAM signaling for neurite out-growth R-HSA-419037 NCAM1 interactions R-HSA-422475 Axon guidance,GO:0005891 voltage-gated calcium channel complex ISS,GO:0006810 transport 9495342 TAS GO:0007268 chemical synaptic transmission IEA GO:0010045 response to nickel cation IEA GO:0034765 regulation of ion transmembrane transport IEA GO:0042391 regulation of membrane potential 21084288 IDA GO:0045956 positive regulation of calcium ion-dependent exocytosis IBA GO:0060371 regulation of atrial cardiac muscle cell membrane depolarization IEA GO:0070509 calcium ion import 21084288 IDA GO:0070588 calcium ion transmembrane transport IEA GO:0086010 membrane depolarization during action potential IBA GO:0086015 SA node cell action potential ISS GO:0086016 AV node cell action potential ISS GO:0086018 SA node cell to atrial cardiac muscle cell signalling ISS GO:0086027 AV node cell to bundle of His cell signaling ISS GO:0086045 membrane depolarization during AV node cell action potential ISS GO:0086046 membrane depolarization during SA node cell action potential ISS GO:0086091 regulation of heart rate by cardiac conduction ISS,21084288 IDA GO:0008332 low voltage-gated calcium channel activity ISS GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential ISS GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential 21084288 IPI GO:0097110 scaffold protein binding,MAPK signaling pathway - Homo sapiens (human) hsa04010 Calcium signaling pathway - Homo sapiens (human) hsa04020 Circadian entrainment - Homo sapiens (human) hsa04713 Type II diabetes mellitus - Homo sapiens (human) hsa04930,CHEMBL CHEMBL1210766,O95180,Voltage-gated T-type calcium channel alpha-1H subunit,1.0,PRIMARY,NO,Fc1cc(F)cc(NC(=O)N2CCC3(CC2)C(N(C3=O)c4cccc(Cl)c4)c5ccccn5)c1,2,3,"InChI=1S/C25H21ClF2N4O2/c26-16-4-3-5-20(12-16)32-22(21-6-1-2-9-29-21)25(23(32)33)7-10-31(11-8-25)24(34)30-19-14-17(27)13-18(28)15-19/h1-6,9,12-15,22H,7-8,10-11H2,(H,30,34)",YCIFLEOHCOBQNX-UHFFFAOYSA-N,"c(""Vanilloid receptor"", ""Voltage-gated T-type calcium channel alpha-1H subunit"")",8912,CAC1H,Developmental Biology R-HSA-1266738 NCAM signaling for neurite out-growth R-HSA-375165 NCAM1 interactions R-HSA-419037 Axon guidance R-HSA-422475,voltage-gated calcium channel complex IEA GO:0005891 integral component of membrane IDA 21084288 GO:0016021,transport GO:0006810 TAS 9670923 muscle contraction GO:0006936 TAS 9670923 muscle organ development GO:0007517 NAS 9670923 myoblast fusion GO:0007520 TAS 10861024 regulation of heart contraction GO:0008016 TAS 9670923 aldosterone biosynthetic process GO:0032342 IMP 19342457 cellular response to hormone stimulus GO:0032870 IEP 19342457 cortisol biosynthetic process GO:0034651 IMP 19342457 regulation of ion transmembrane transport GO:0034765 IEA cellular response to potassium ion GO:0035865 IEP 19342457 regulation of membrane potential GO:0042391 IDA 21084288 calcium ion import GO:0070509 IDA 21084288 calcium ion transmembrane transport GO:0070588 IEA membrane depolarization during action potential GO:0086010 IBA positive regulation of acrosome reaction GO:2000344 IMP 20394732,low voltage-gated calcium channel activity GO:0008332 21084288 IDA metal ion binding GO:0046872 IEA scaffold protein binding GO:0097110 21084288 IPI,hsa04010 MAPK signaling pathway - Homo sapiens (human) hsa04020 Calcium signaling pathway - Homo sapiens (human) hsa04713 Circadian entrainment - Homo sapiens (human),CHEMBL