Compound,SMILES,TRPC6 EC50 (¦ÌM),TRPC4¦Â+MOR IC50 (¦ÌM),TRPC3 EC50 (¦ÌM),TRPC7 EC50 (¦ÌM),CAS
6a,CC(OC(N1CCC(C(O)=O)CC1)=O)(C)C,,,,,84358-13-4
6b,O=C(N1CCC(C(O)=O)CC1)OCC,,,,,118133-15-6
6c,O=C(N1CCC(C(O)=O)CC1)OCC2=CC=CC=C2,,,,,10314-98-4
7a,CC(CC1)(C(OCC)=O)CCN1C(OCC)=O,,,,,1589567-86-1
7b,CC(CC1)(C(OCC)=O)CCN1C(OC(C)(C)C)=O,,,,,189442-87-3
8a,O=C(CC(OCC)=O)C(CC1)(C)CCN1C(OCC)=O,,,,,1589567-88-3
8b,O=C(CC(OCC)=O)C(CC1)(C)CCN1C(OC(C)(C)C)=O,,,,,1603907-56-7
8c,O=C(CC(OCC)=O)C(CC1)CCN1C(OCC2=CC=CC=C2)=O,,,,,167414-75-7
8d,O=C(CC(OCC)=O)C(CC1)CCN1C(OC(C)(C)C)=O,,,,,479630-08-5
11a,NC1=C(C2=CC=C(F)C=C2)C(C)=NN1,,,,,62538-16-3
11b,NC1=C(C2=CC=C(Cl)C=C2)C(C)=NN1,,,,,214416-39-4
11c,NC1=C(C2=CC=C(C(F)(F)F)C=C2)C(C)=NN1,,,,,1221133-66-9
11d,NC1=C(C2=CC=C([N+]([O-])=O)C=C2)C(C)=NN1,,,,,1312444-79-3
4a,OC1=CC(C2CCN(C(C3=CN=C(Br)C=C3)=O)CC2)=NC4=C(C5=CC=C(F)C=C5)C(C)=NN14,12.3 ± 1.2,~10,,,
4b,OC1=CC(C2(C)CCN(S(C3=CC=C(OC)C=C3)(=O)=O)CC2)=NC4=C(C5=CC=C(F)C=C5)C(C)=NN14,NA,NA,,,
4c,OC1=CC(C2(C)CCN(C(CC)=O)CC2)=NC3=C(C4=CC=C(F)C=C4)C(C)=NN13,NA,NA,,,
4d,OC1=CC(C2(C)CCN(C(C(C)(C)C)=O)CC2)=NC3=C(C4=CC=C(F)C=C4)C(C)=NN13,NA,NA,,,
4e,OC1=CC(C2(C)CCN(S(C3=C(F)C=CC=C3F)(=O)=O)CC2)=NC4=C(C5=CC=C([N+]([O-])=O)C=C5)C(C)=NN14,NA,NA,,,
4f,OC1=CC(C2(C)CCN(C(CC3=CC=C(OC)C(OC)=C3)=O)CC2)=NC4=C(C5=CC=C([N+]([O-])=O)C=C5)C(C)=NN14,NA,NA,,,
4g,OC1=CC(C2(C)CCN(C(OCC)=O)CC2)=NC3=C(C4=CC=C([N+]([O-])=O)C=C4)C(C)=NN13,~8,NA,,,
4h,OC1=CC(C2(C)CCN(C(OC(C)(C)C)=O)CC2)=NC3=C(C4=CC=C(F)C=C4)C(C)=NN13,NA,NA,,,
4i,OC1=CC(C2CCN(C(OCC)=O)CC2)=NC3=C(C4=CC=C([N+]([O-])=O)C=C4)C(C)=NN13,~2,NA,,,
4j,OC1=CC(C2CCN(C(CC)=O)CC2)=NC3=C(C4=CC=C(F)C=C4)C(C)=NN13,28.8 ± 8.3,~35,,,
4k,CC1=NN2C(O)=CC(C3CCN(C(C(C)(C)C)=O)CC3)=NC2=C1C4=CC=C(F)C=C4,NA,NA,,,
4l,OC1=CC(C2CCN(C(OC(C)(C)C)=O)CC2)=NC3=C(C4=CC=C(Cl)C=C4)C(C)=NN13,NA,NA,,,
4m,OC1=CC(C2CCN(C(OCC3=CC=CC=C3)=O)CC2)=NC4=C(C5=CC=C(Cl)C=C5)C(C)=NN14,7.79 ± 0.05,NA,0.138 ± 0.023,2.05 ± 0.02,
4n,OC1=CC(C2CCN(C(OCC)=O)CC2)=NC3=C(C4=CC=C(C(F)(F)F)C=C4)C(C)=NN13,1.39 ± 0.01,NA,0.019 ± 0.002,0.89 ± 0.01,
4o,OC1=CC(C2CCN(C(OCC)=O)CC2)=NC3=C(C4=CC=C(F)C=C4)C(C)=NN13,4.66 ± 0.03,NA,0.450 ± 0.087,6.28 ± 0.02,
4p,OC1=CC(C2CCN(C(OCC3=CC=CC=C3)=O)CC2)=NC4=C(C5=CC=C(F)C=C5)C(C)=NN14,3.91 ± 0.02,NA,0.236 ± 0.047,3.24 ± 0.01,