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["Supplementary Table S1a. Drug and compound collection used in the drug sensitvity and resistance testing assay"]
[]
["Drug_Name","start conc.","max. conc. Tested","Trade names","Mechanism/Targets","High phase/Approval status","Active/inactive in clinic","Prodrug Idenitifier","Supplier","Supplier Ref"]
["JQ1",1,10000,null,"BET family inhibitor","Probe","Inactive",null,"SGC","SGCBD01(+)"]
["1-methyl-D-tryptophan aq",0.5,5000,null,"Indolamine 2,3-dioxygenase 1 and 2 inhibitor","Investigational (Ph 2)",null,null,"Sigma-Aldrich","452483"]
["15D-PGJ2",0.08,800,null,"Endogenous PPARγ ligand, prostaglandin, NFkB signaling inhibitor","Probe","Inactive",null,"Merck","538927-2"]
["2-methoxyestradiol",1,10000,null,"Angiogenesis inhibitor","Investigational (Ph 2)","Inactive",null,"Cayman Chemical Company","13021"]
["4-hydroxytamoxifen",1,10000,null,"Selective estrogen receptor modulator","Investigational as a gel preparation",null,null,"Santa Cruz Biotechnology","sc-3542"]
["8-amino-adenosine",5,50000,null,"Nucleoside analog, RNA synthesis inhibitor","Probe",null,null,"Northwestern University","NWU 8NH2"]
["Abiraterone",0.5,5000,null,"P450 17alpha-hydroxylase-17,20-lyase inhibitor","Approved",null,null,"Selleck","S1123"]
["ABT-751",1,10000,null,"Mitotic inhibitor. Colchicine site binding microtubule depolymerizer.","Investigational (Ph 2)","Inactive",null,"Selleck","S1165"]
["Afatinib",0.1,1000,"Gilotrif, Giotrif","EGFR inhibitor","Approved",null,null,"Selleck","S1011"]
["AG490",10,100000,null,"JAK inhibitor","Probe",null,null,"Merck",658411]
["Alisertib",1,10000,null,"Aurora A inhibitor","Investigational (Ph 3)",null,null,"ChemieTek","CT-M8237"]
["Allopurinol",1,10000,"Zyloprim","Xanthine oxidase inhibitor","Approved",null,null,"National Cancer Institute","NSC 1390-R/3"]
["Alvespimycin",0.1,1000,null,"HSP90 inhibitor","Investigational (Ph 2)","Inactive",null,"Selleck","S1142"]
["Alvocidib",1,10000,null,"CDK inhibitor","Investigational (Ph 2)",null,null,"Selleck","S1230"]
["Aminoglutethimide",1,10000,null,"Anti-steroid, aromatase inhibitor","Approved",null,null,"Sigma-Aldrich","A9657"]
["Amonafide",1,10000,null,"Topoisomerase II inhibitor / DNA intercalator","Investigational (Ph 3)","Inactive",null,"Selleck","S1367"]
["Anagrelide",1,10000,"Agrylin, Xagrid","PDE-3, PLA2 inhibitor","Approved",null,null,"Tocris Biosciences","2432"]
["Anastrozole",1,10000,null,"Aromatase inhibitor","Approved",null,null,"National Cancer Institute","NSC 719344-F/2"]
["Apitolisib",1,10000,null,"PI3K/mTOR inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-G0980"]
["APR-246",1,10000,null,"p53 activator, thioredoxin reductase 1 inhibitor","Investigational (Ph 1)",null,null,"Tocris Biosciences","3710"]
["ARN 509",1,10000,null,"AR antagonist","Investigational (Ph 2)",null,null,"Axon Medchem","Axon 1979"]
["Arsenic(III) oxide",0.25,2500,null,"Thioredoxin reductase inhibitor; cytotoxic chemotherapeutic","Approved",null,null,"Sigma-Aldrich","202673"]
["AT 101",10,100000,null,"Bcl-2 family inhibitor","Investigational (Ph 2)",null,null,"Selleck","S2812"]
["AT-406",1,10000,null,"XIAP, cIAP1, cIAP2 inhibitor","Investigational (Ph 1)",null,null,"Selleck","S2754"]
["AT9283",0.1,1000,null,"Aurora A & B, Jak2, Flt, Abl inhibitor","Investigational (Ph 2)",null,null,"Selleck","S1134"]
["Atorvastatin",1,10000,"Lipitor","HMG CoA reductase inhibitor","Approved",null,null,"ChemieTek","CT-ATOR"]
["Auranofin",0.25,2500,null,"Antirheumatic agent","Approved",null,null,"Sigma-Aldrich","A6733"]
["AVN944",1,10000,null,"IMPDH inhibitor","Investigational (Ph 2)","Inactive",null,"ChemieTek","CT-AVN944"]
["Axitinib",1,10000,"Inlyta","VEGFR, PDGFR, KIT inhibitor","Approved",null,null,"LC Laboratories","A-1107"]
["AZ 3146",1,10000,null,"Mps1 kinase (TTK) inhibitor","Probe","Inactive",null,"Tocris Biosciences","3994"]
["Azacitidine",1,10000,"Vidaza","Nucleoside analog DNA methyl transferase inhibitor","Approved",null,"Prodrug, activated in the cells","National Cancer Institute","NSC 102816-P/21"]
["AZD1152-HQPA",0.1,1000,null,"Aurora B inhibitor","Investigational (Ph 3)","Inactive",null,"ChemieTek","CT-A1152H"]
["AZD1480",0.1,1000,null,"JAK1/2, FGFR inhibitor","Investigational (Ph 1)",null,null,"ChemieTek","CT-A1480"]
["AZD2014",1,10000,null,"mTOR inhibitor, ATP-competitive","Investigational (Ph 1)",null,null,"Selleck","S2783"]
["AZD4547",0.1,1000,null,"FGFR inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-A4547"]
["AZD7762",0.1,1000,null,"Chk1 inhibitor","Investigational (Ph 1)","Inactive",null,"Axon Medchem","Axon 1399"]
["AZD8055",1,10000,null,"mTOR inhibitor","Investigational (Ph 1)",null,null,"ChemieTek","CT-A8055-3"]
["Belinostat",1,10000,null,"HDAC inhibitor","Approved",null,null,"ChemieTek","CT-BELI"]
["Bendamustine",1,10000,null,"Nitrogen mustard alkylating agent","Approved",null,"Prodrug, activated in the liver","National Cancer Institute","NSC 138783"]
["Bexarotene",1,10000,null,"Antineoplastic agent; retinoid specifically selective for retinoid X receptors","Approved",null,null,"Santa Cruz Biotechnology","sc-217753"]
["BI 2536",0.1,1000,null,"PLK1 inhibitor","Investigational (Ph 2)","Inactive",null,"Selleck","S1109"]
["Bicalutamide",1,10000,"Casodex, Cosudex, Calutide, Kalumid","Nonsteriodal antiandrogen","Approved",null,null,"ChemieTek","CT-BIC"]
["BIIB021",1,10000,null,"HSP90 inhibitor","Investigational (Ph 2)","Inactive",null,"Selleck","S1175"]
["Bimatoprost",0.55,5500,"Latisse, Lumigan, Prostamide","Prostaglandin analog","Approved",null,null,"Selleck","S1407"]
["Binimetinib",0.1,1000,null,"MEK1/2 inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-A162"]
["Bleomycin",1,10000,null,"Glycopeptide antibiotic; causes DNA breaks","Approved",null,null,"Selleck","S1214"]
["BMS-754807",1,10000,null,"IGF1R inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-BMS75"]
["BMS-911543",1,10000,null,"JAK2 inhibitor","Investigational (Ph 1)","Inactive",null,"ChemieTek","CT-BMS911"]
["Bortezomib",0.1,1000,"Velcade, Cytomib","Proteasome inhibitor (26S subunit)","Approved",null,null,"National Cancer Institute","NSC 681239-L/9"]
["Bosutinib",1,10000,"Bosulif","Abl, Src inhibitor","Approved",null,null,"LC Laboratories","B-1788"]
["Brivanib",0.1,1000,null,"VEGFR inhibitor","Investigational (Ph 3)",null,null,"Selleck","S1084"]
["Bryostatin 1",0.01,100,null,"PKC activator","Investigational (Ph 1)",null,null,"Santa Cruz Biotechnology","sc-201407-4 "]
["Buparlisib",1,10000,null,"PI3K inhibitor, pan-class I","Investigational (Ph 2)",null,null,"Selleck","S2247"]
["Busulfan",10,100000,null,"Alkylating antineoplastic agent","Approved",null,"Prodrug, activated in the liver","Sigma-Aldrich","B2635"]
["C646",2.5,25000,null,"p300/CREB-binding protein (CBP) inhibitor","Probe","Inactive",null,"Axon Medchem","Axon 1781"]
["Cabozantinib",0.1,1000,"Cometriq","VEGFR2, Met, FLT3, Tie2, Kit and Ret inhibitor","Approved",null,null,"ChemieTek","CT-XL184"]
["Camptotechin",0.5,5000,null,"Topoisomerase I inhibitor","Probe","Inactive",null,"Tocris Biosciences","1100"]
["Canertinib",1,10000,null,"pan-HER inhibitor","Investigational (Ph 3)","Inactive",null,"LC Laboratories","C-1201"]
["Capecitabine",1,10000,null,"5-FU prodrug","Approved",null,"Prodrug, activated in the liver and tumor","LC Laboratories","C-2799"]
["Carboplatin",1,10000,null,"Platinum-based antineoplastic agent","Approved",null,null,"Selleck","S1215-2"]
["Carfilzomib",0.1,1000,"Kyprolis","Proteasome inhibitor (20S subunit)","Approved",null,null,"ChemieTek","CT-CARF"]
["Carmustine",1,10000,null,"Alkylating agent","Approved",null,"Prodrug, activated in the liver","National Cancer Institute","NSC 409962-T/3"]
["Cediranib",0.1,1000,"Recentin","KDR/Flt/VEGFR inhibitor","Investigational (Ph 3)",null,null,"Selleck","S1017"]
["Celecoxib",1,10000,null,"Selective COX-2 inhibitor","Approved",null,null,"National Cancer Institute","NSC 719627-M/1"]
["Chlorambucil",1,10000,null,"Nitrogen mustard alkylating agent","Approved",null,"Prodrug, activated in the liver","National Cancer Institute","NSC 3088-N/6"]
["Chloroquine",10,100000,null,"Antimalaria agent; chemo/radio sensitizer","Approved",null,null,"Sigma-Aldrich","C6628"]
["Cisplatin",0.1,1000,null,"Platinum-based antineoplastic agent","Approved",null,null,"Selleck","S1166-2"]
["Cladribine",0.1,1000,"Leustatin","Antimetabolite; Purine analog","Approved",null,"Prodrug, activated in the cells","National Cancer Institute","NSC 105014-F/2"]
["Clofarabine",1,10000,"Evoltra, Clolar","Antimetabolite; Purine analog","Approved",null,"Prodrug, activated in the cells","National Cancer Institute","NSC 606869-X/4"]
["Clomifene",1,10000,null,"Selective estrogen receptor modulator","Approved",null,null,"Selleck","S2561"]
["CPI-613",1,10000,null,"pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase inhibitor","Investigational (Ph 2)",null,null,"Selleck","S2776"]
["Crenolanib",1,10000,null,"PDGFRA and PDGFRB inhibitor","Investigational (Ph 2)",null,null,"Selleck","S2730"]
["Crizotinib",0.1,1000,"Xalkori","ALK, c-Met inhibitor","Approved",null,null,"Selleck","S1068"]
["CUDC-101",1,10000,null,"HDAC & EGFR, Her2 inhibitor","Investigational (Ph 1)",null,null,"Selleck","S1194"]
["Cyclophosphamide",4,40000,null,"Alkylating agent","Approved",null,"Prodrug, activated in the liver","Selleck","S1217"]
["Cytarabine",1,10000,null,"Antimetabolite, interferes with DNA synthesis","Approved",null,"Prodrug, activated in the cells","National Cancer Institute","NSC 63878-P/19"]
["Dabrafenib",0.25,2500,"Tafinlar","B-Raf(V600E) inhibitor","Approved",null,null,"ChemieTek","CT-DABR"]
["Dacarbazine",1,10000,null,"Alkylating agent","Approved",null,"Prodrug, activated in the liver","National Cancer Institute","NSC 45388-R/74"]
["Dacomitinib",0.1,1000,null,"pan-HER inhibitor","Investigational (Ph 3)",null,null,"ChemieTek","CT-DACO"]
["Dactinomycin",0.1,1000,null,"RNA and DNA synthesis inhibitor","Approved",null,null,"National Cancer Institute","NSC 3053-Y/14"]
["Dactolisib",0.1,1000,null,"mTOR/(PI3K) inhibitor","Investigational (Ph 2)",null,null,"LC Laboratories","N-4288"]
["Danusertib",1,10000,null,"Aurora, Ret, TrkA, FGFR-1 inhibitor","Investigational (Ph 2)","Inactive",null,"Selleck","S1107"]
["Daporinad",0.1,1000,null,"NAMPT inhibitor","Probe","Inactive",null,"Axon Medchem","Axon 1546"]
["Dasatinib",0.1,1000,"Sprycel","Abl, Src, Kit, EphR... Inhibitor","Approved",null,null,"LC Laboratories","D-3307"]
["Daunorubicin",0.1,1000,null,"Topoisomerase II inhibitor","Approved",null,null,"National Cancer Institute","NSC 82151-A/44"]
["Decitabine",1,10000,null,"Nucleoside analog DNA methyl transferase inhibitor","Approved",null,"Prodrug, activated in the cells","Selleck","S1200"]
["Deferoxamine",1,10000,null,"Iron chelator","Approved (non-oncology)",null,null,"Sigma-Aldrich","D9533"]
["Dexamethasone",1,10000,"Decadron, Dexpak","Immunosuppresant; glucocorticoid","Approved",null,null,"Selleck","S1322"]
["Dinaciclib",0.1,1000,null,"CDK inhibitor","Investigational (Ph 3)",null,null,"ChemieTek","CT-DINA"]
["Docetaxel",0.1,1000,"Taxotere, Docecad","Mitotic inhibitor, taxane microtubule stabilizer","Approved",null,null,"LC Laboratories","D-1000"]
["Doramapimod",1,10000,null,"p38MAPK inhibitor","Investigational (Ph 1)","Inactive",null,"Axon Medchem","Axon 1358"]
["Dovitinib",1,10000,null,"FGFR inhibitor","Investigational (Ph 3)",null,null,"Selleck","S1018"]
["Doxorubicin",0.1,1000,"Adriamycin","Topoisomerase II inhibitor","Approved",null,null,"Sigma-Aldrich","D1515"]
["EMD1214063",0.1,1000,null,"c-Met inhibitor","Investigational (Ph 1)",null,null,"ChemieTek","CT-EMD063"]
["Entinostat",1,10000,null,"HDAC inhibitor","Investigational (Ph 2)",null,null,"LC Laboratories","E-3866"]
["Enzalutamide",1,10000,"Xtandi","AR antagonist","Approved",null,null,"Axon Medchem","Axon 1613"]
["Enzastaurin",1,10000,null,"PKCbeta inhibitor","Investigational (Ph 3)",null,null,"LC Laboratories","E-4506"]
["Erlotinib",1,10000,"Tarceva","EGFR inhibitor","Approved",null,null,"National Cancer Institute","NSC 718781-R/4"]
["Estramustine",1,10000,null,"Alkylating agent","Approved",null,"Prodrug, activated in the liver","Sigma-Aldrich","E0407"]
["Etoposide",1,10000,null,"Topoisomerase II inhibitor","Approved",null,null,"National Cancer Institute","NSC 141540-H/184"]
["Everolimus",0.01,100,"Afinitor, Certican, Zortress","binds FKBP12, causes inhibition of mTORC1","Approved",null,null,"LC Laboratories","E-4040"]
["Exemestane",1,10000,null,"Aromatase inhibitor","Approved",null,null,"National Cancer Institute","NSC 713563-U/2"]
["Fasudil",5,50000,null,"ROCK, PKA, PKG, PRK inhibitor, prodrug","Approved (Japan)",null,"Prodrug, activated in the liver","LC Laboratories","H-2330"]
["FG-4592",1,10000,null,"HIF prolyl hydroxylase inhibitor","Investigational (Ph 2)",null,null,"Selleck","S1007"]
["Finasteride",1,10000,null,"type II 5-alpha reductase inhibitor","Approved",null,null,"Tocris Biosciences","3293"]
["Fingolimod",1,10000,"Gilenya","S1PR antagonist","Approved",null,null,"LC Laboratories","F-4633"]
["Floxuridine",1,10000,null,"Antimetabolite; Analog of 5-fluorouracil","Approved",null,"Prodrug, activated in the cells","National Cancer Institute","NSC 27640-Z/31"]
["Fludarabine",1,10000,"Fludara","Antimetabolite; Purine analog","Approved",null,"Prodrug, activated in the cells","National Cancer Institute","NSC 312887-C/7"]
["Fluorouracil",1,10000,null,"Antimetabolite","Approved",null,"Prodrug, activated in the cells","National Cancer Institute","NSC 19893-G/4"]
["Flutamide",1,10000,null,"Nonsteroidal antiandrogen","Approved",null,null,"Tocris Biosciences","4094"]
["Foretinib",0.1,1000,null,"MET, VEGFR2 inhibitor","Investigational (Ph 2)",null,null,"Selleck","S1111"]
["Fostamatinib",0.25,2500,null,"Syk inhibitor","Investigational (Ph 2)",null,null,"Selleck","S2206-3"]
["Fulvestrant",0.1,1000,null,"Estrogen receptor antagonist","Approved",null,null,"Selleck","S1191"]
["Galiellalactone",5,50000,null,"STAT3-DNA interaction inhibitor","Probe","Inactive",null,"Santa Cruz Biotechnology","sc-202165-6"]
["Galunisertib",0.1,1000,null,"TGF-B/Smad inhibitor","Investigational (Ph 2)",null,null,"Selleck","S2230"]
["Gandotinib",1,10000,null,"JAK2 inhibitor","Investigational (Ph 2)","Inactive",null,"Selleck","S2179"]
["GDC-0068",1,10000,null,"Akt inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-G0068"]
["Gefitinib",1,10000,"Iressa","EGFR inhibitor","Approved",null,null,"LC Laboratories","G-4408"]
["Gemcitabine",0.1,1000,"Gemsar, Gemzar","Antimetabolite; Nucleoside analog","Approved",null,"Prodrug, activated in the cells","National Cancer Institute","NSC 613327-S/2"]
["Goserelin",1,10000,null,"Gonadotropin releasing hormone superagonist","Approved",null,null,"Tocris Biosciences","3592"]
["GSK-J4",10,100000,null,"JMJD3 (histone demethylase) inhibitor","Probe","Inactive",null,"Selleck","S7070-2"]
["GSK2636771",1,10000,null,"PI3K beta selective inhibitor","Investigational (Ph 1)",null,null,"ChemieTek","CT-GSK263"]
["GSK269962",1,10000,null,"ROCK1 and ROCK2 inhibitor","Probe","Inactive",null,"Tocris Biosciences","4009"]
["GSK343",1,10000,null,"EZH2 inhibitor","Probe","Inactive",null,"SGC","SGCGSK343"]
["GSK650394",1,10000,null,"SGK1 & 2 inhibitor","Probe","Inactive",null,"Tocris Biosciences","3572"]
["Hydroxyurea",10,100000,"Myelostat","Antineoplastic agent","Approved",null,"Prodrug, activated in the cells","Sigma-Aldrich","H8627"]
["I-BET151",1,10000,null,"BET family inhibitor","Probe","Inactive",null,"ChemieTek","CT-BET151"]
["Ibrutinib",0.1,1000,"Imbruvica","Btk inhibitor","Approved",null,null,"Selleck","S2680"]
["Idarubicin",0.1,1000,"Zavedos, Idamycin","Topoisomerase II inhibitor","Approved",null,null,"Sigma-Aldrich","I1656"]
["Idelalisib",1,10000,"Zydelig","PI3K inhibitor, p110δ-selective","Approved",null,null,"ChemieTek","CT-CAL101"]
["Ifosfamide",1,10000,null,"Nitrogen mustard alkylating agent","Approved",null,"Prodrug, activated in the liver","National Cancer Institute","NSC 109724-X/4"]
["Imatinib",1,10000,"Gleevec, Glivec","Abl, Kit, PDGFRB inhibitor","Approved",null,null,"LC Laboratories","C-5508"]
["Imiquimod",0.25,2500,null,"Immunomodulatory agent, TLR7 agonist","Approved",null,null,"National Cancer Institute","NSC 369100-F/4"]
["Indibulin",1,10000,null,"Mitoric inhibitor. Microtubule depolymerizer","Investigational (Ph 2)","Inactive",null,"Tocris Biosciences","3728"]
["Iniparib",1,10000,null,"PARP inhibitor","Investigational (Ph 3)","Inactive",null,"Axon Medchem","Axon 1566"]
["INK128",0.1,1000,null,"mTOR inhibitor","Investigational (Ph 1)",null,null,"ChemieTek","CT-INK128"]
["IOX-2",5,50000,null,"PHD2 inhibitor","Probe","Inactive",null,"Tocris Biosciences","4451"]
["Irinotecan",1,10000,"Camptosar","Topoisomerase I inhibitor.  Camptothecin prodrug analog","Approved",null,"Prodrug, activated in the liver","LC Laboratories","I-4122"]
["Ixabepilone",0.1,1000,"Ixempra","Mitotic inhibitor. Epothilone microtubule stabilizer.","Approved",null,null,"National Cancer Institute","NSC 747973-W/3"]
["Lapatinib",0.1,1000,"Tykerb, Tyverb","HER2, EGFR inhibitor","Approved",null,null,"LC Laboratories","L-4804"]
["Lasofoxifene",0.1,1000,"Oporia","Selective estrogen receptor modulator","Approved",null,null,"Santa Cruz Biotechnology","sc-211721"]
["Lenalidomide",1,10000,"Revlimid","Immunomodulatory","Approved",null,null,"LC Laboratories","L-5499"]
["Lestaurtinib",0.1,1000,null,"FLT3, JAK2, TrkA, TrkB, TrkC inhibitor","Investigational (Ph 3)",null,null,"LC Laboratories","L-6307"]
["Letrozole",1,10000,"Femara","Aromatase inhibitor","Approved",null,null,"National Cancer Institute","NSC 719345-G/2"]
["Levamisole",1,10000,null,"Immunomodulatory agent","Approved",null,null,"Sigma-Aldrich","L9756"]
["Linifanib",0.1,1000,null,"VEGFR, PDGFR, CSF-1R, FLT3 inhibitor","Investigational (Ph 3)",null,null,"Selleck","S1003"]
["Linsitinib",1,10000,null,"IGF1R, IR inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-O906"]
["LLL12",3,30000,null,"STAT3 SH2 domain inhibitor","Probe",null,null,"Merck",573131]
["Lomeguatrib",1,10000,null,"O6-methylguanine-DNA methyltransferase inhibitor","Investigational (Ph 2)","Inactive",null,"Tocris Biosciences","4359"]
["Lomustine",1,10000,null,"Alkylating nitrosourea compound","Approved",null,"Prodrug, activated in the liver","National Cancer Institute","NSC 79037-R/12"]
["Luminespib ",0.1,1000,null,"HSP90 inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-AUY922"]
["Masitinib",1,10000,null,"KIT inhibitor","Investigational (Ph 3)",null,null,"LC Laboratories","M-7007"]
["Mechlorethamine",10,100000,"Mustargen","Nitrogen mustard alkylating agent","Approved",null,"Prodrug, activated in the liver","Sigma-Aldrich","122564"]
["Megestrol acetate",1,10000,"Megace","Progestogen","Approved",null,null,"National Cancer Institute","NSC 71423-Q/12"]
["Melphalan",1.25,12500,null,"Nitrogen mustard alkylating agent","Approved",null,"Prodrug, activated in the liver","Sigma-Aldrich","M2011"]
["Mepacrine",5,50000,null,"Unclear. PLA2 inhibitor. NF-kB inhibitor, p53 activator","Approved",null,null,"Sigma-Aldrich","Q3251"]
["Mercaptopurine",1,10000,null,"Antimetabolite","Approved",null,"Prodrug, activated in the cells","National Cancer Institute","NSC 755-Z/13"]
["Metformin",10,100000,null,"AMPK activator","Approved (non-oncology)",null,null,"Tocris Biosciences","2864"]
["Methotrexate",5,50000,null,"Antimetabolite; Anti-folate agent","Approved",null,null,"Selleck","S1210"]
["Methylprednisolone",1,10000,null,"Immunosuppressant","Approved",null,null,"Santa Cruz Biotechnology","sc-205749"]
["MGCD-265",1,10000,null,"MET, VEGFR-1, -2, -3, RON, TIE2 inhib","Investigational (Ph 2)",null,null,"Selleck","S1361"]
["Midostaurin",1,10000,null,"PKC, PKA, S6K and EGFR inhibitor","Investigational (Ph 3)",null,null,"LC Laboratories","P-7600"]
["Mitomycin C",1,10000,null,"Antineoplastic anatibiotic; DNA crosslinker","Approved",null,null,"National Cancer Institute","NSC 26980-J/65"]
["Mitotane",1,10000,null,"Antineoplastic agent","Approved",null,null,"National Cancer Institute","NSC 38721-U/3"]
["Mitoxantrone",0.1,1000,null,"Topoisomerase II inhibitor","Approved",null,null,"National Cancer Institute","NSC 279836-C/2"]
["MK-0752",0.1,1000,null,"gamma-secretase/notch inhibitor","Investigational (Ph 2)",null,null,"Selleck","S2660"]
["MK-2206",0.1,1000,null,"AKT inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-MK2206"]
["MK1775",1,10000,null,"Wee1 inhibitor","Investigational (Ph 2)",null,null,"Axon Medchem","Axon 1494"]
["Mocetinostat",1,10000,null,"HDAC inhibitor (HDAC1 & 2-selective)","Investigational (Ph 2)",null,null,"Selleck","S1122"]
["Momelotinib",1,10000,null,"JAK1 & 2 inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-CYT387"]
["Motesanib",1,10000,null,"VEGFR, PDGFR, Ret, Kit inhibitor","Investigational (Ph 2)",null,null,"Selleck","S1032"]
["Navitoclax",1,10000,null,"Bcl-2/Bcl-xL inhibitor","Investigational (Ph 2)",null,null,"Selleck","S1001-2"]
["Nelarabine",1,10000,"Arranon,  Atriance","Nucleoside analog, DNA, RNA synth inhibitor","Approved",null,"Prodrug, activated selectively in T-cells","SequoiaResearchProducts","SRP003328n"]
["Neratinib",0.1,1000,null,"EGFR inhibitor","Investigational (Ph 3)",null,null,"Selleck","S2150(2)"]
["Nilotinib",1,10000,"Tasigna","Abl inhibitor","Approved",null,null,"LC Laboratories","N-8207"]
["Nilutamide",1,10000,null,"Nonsteroidal antiandrogen","Approved",null,null,"Santa Cruz Biotechnology","sc-203644"]
["Nintedanib",1,10000,"Vargatef, Ofev","VEGFR, PDGFR, FGFR inhibitor","Approved",null,null,"Selleck","S1010"]
["Niraparib",1,10000,null,"PARP inhibitor","Investigational (Ph 1)",null,null,"ChemieTek","CT-MK4827"]
["Nutlin-3",1,10000,null,"MDM2 inhibitor","Probe","Inactive",null,"Selleck","S1061"]
["NVP-BGJ398",0.1,1000,null,"FGFR inhibitor","Investigational (Ph 1)",null,null,"ChemieTek","CT-BGJ398"]
["Obatoclax",1,10000,null,"Bcl-2 family inhibitor","Investigational (Ph 3)","Inactive",null,"Selleck","S1057"]
["Olaparib",1,10000,"Lynparza","PARP inhibitor","Approved",null,null,"LC Laboratories","O-9201"]
["Omacetaxine",1,10000,"Synribo","Protein synthesis inhib (80 S ribosome)","Approved",null,null,"Santa Cruz Biotechnology","sc-202652"]
["Omipalisib",0.1,1000,null,"PI3K/mTOR inhibitor","Investigational (Ph 1)",null,null,"Selleck","S2658"]
["OSI-027",1,10000,null,"mTOR inhibitor","Investigational (Ph 2)","Inactive",null,"ChemieTek","CT-O027"]
["Oxaliplatin",1,10000,null,"Platinum-based antineoplastic agent","Approved",null,null,"Selleck","S1224-2"]
["PAC-1",1,10000,null,"procaspase-3 activator","Investigational (Ph 1)",null,null,"Selleck","S2738"]
["Paclitaxel",0.1,1000,"Taxol","Mitotic inhibitor, taxane microtubule stabilizer","Approved",null,null,"National Cancer Institute","NSC 125973-L/68"]
["Palbociclib",1,10000,"Ibrance","CDK inhibitor (Cdk4/6)","Approved",null,null,"Selleck","S1116"]
["Panobinostat",0.1,1000,"Farydak, Faridak","HDAC inhibitor","Approved",null,null,"LC Laboratories","P-3703"]
["Patupilone",0.1,1000,null,"Mitotic inhibitor, epothilone microtubule stabilizer","Investigational (Ph 3)","Inactive",null,"LC Laboratories","E-5500-2"]
["Pazopanib",1,10000,"Votrient","VEGFR inhibitor","Approved",null,null,"LC Laboratories","P-6706"]
["Pemetrexed",1,10000,"Alimta","Dihydrofolate reductase inhibitor","Approved",null,null,"LC Laboratories","P-7177"]
["Pentostatin",1,10000,null,"Antimetabolite; Purine analog","Approved",null,"Prodrug, activated in the cells","National Cancer Institute","NSC 218321-O/48"]
["Perifosine",0.25,2500,null,"AKT/PI3K inhibitor","Investigational (Ph 3)",null,null,"Selleck","S1037"]
["Pevonedistat",1,10000,null,"NAE inhibitor","Investigational (Ph 1)",null,null,"ChemieTek","CT-M4924"]
["PF 431396",1,10000,null,"FAK/PYK2 inhibitor","Probe","Inactive",null,"Tocris Biosciences","4278"]
["PF-00477736",1,10000,null,"Chk1 inhibitor","Investigational (Ph 1)","Inactive",null,"Axon Medchem","Axon 1379-2"]
["PF-04691502",1,10000,null,"PI3K/mTOR inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-PF1502"]
["PF-04708671",1,10000,null,"p70S6K inhibitor","Probe","Inactive",null,"Sigma-Aldrich","PZ0143"]
["PF-3845",1,10000,null,"FAAH inhibitor","Probe","Inactive",null,"Selleck","S2666"]
["PF-4800567",1,10000,null,"CK1epsilon inhibitor","Probe","Inactive",null,"Tocris Biosciences","4281"]
["PF-670462",1,10000,null,"CK1epsilon and CK1delta inhibitor","Probe","Inactive",null,"Tocris Biosciences","3316"]
["PFI-1",1,10000,null,"Selective chemical probe for BET Bromodomains","Probe","Inactive",null,"SGC","SGCPFI"]
["Pictilisib",1,10000,null,"PI3K inhibitor, pan-class I","Investigational (Ph 2)",null,null,"LC Laboratories","G-9252"]
["Pilaralisib",0.25,2500,null,"PI3K inhibitor.  Pan-class I","Investigational (Ph 2)",null,null,"Medchemexpress","HY-16526"]
["Pilocarpine",4,40000,"Salagen","Non-selective muscarinic receptor agonist","Approved",null,null,"Tocris Biosciences","0694"]
["Pimasertib",1,10000,null,"MEK1/2 inhibitor","Investigational (Ph 2)",null,null,"Selleck","S1475"]
["Pipobroman",1,10000,null,"Alkylating agent","Approved",null,"Prodrug, activated in the liver","National Cancer Institute","NSC 25154-X/2"]
["Plerixafor",1,10000,"Mozobil","CXCR4 antagonist","Approved",null,null,"Cayman Chemical Company","10011332-2"]
["Plicamycin",1,10000,null,"RNA synthesis inhibitor","Approved",null,null,"Santa Cruz Biotechnology","sc-200909-5"]
["Pomalidomide",1,10000,null,"Immunomodulatory agent, anti-angiogenic","Approved",null,null,"Sigma-Aldrich","P0018"]
["Ponatinib",0.1,1000,"Iclusig","Broad TK inhibitor","Approved",null,null,"Selleck","S1490"]
["Pravastatin",1,10000,null,"HMG CoA reductase inhibitor","Approved (non-oncology)",null,null,"Tocris Biosciences","2318"]
["Prednisolone",1,10000,null,"Immunomodulatory agent","Approved",null,null,"Santa Cruz Biotechnology","sc-205815"]
["Prednisone",1,10000,null,"Immunomodulatory agent","Approved",null,"Prodrug, activated in the liver","Santa Cruz Biotechnology","sc-205816"]
["Procarbazine",1,10000,null,"Alkylating agent","Approved",null,"Prodrug, activated in the liver","National Cancer Institute","NSC 77213-K/6"]
["Quisinostat",0.1,1000,null,"HDAC inhibitor","Investigational (Ph 2)",null,null,"Active Biochem","A-1162"]
["Quizartinib",0.1,1000,null,"FLT3 inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-AC220"]
["Rabusertib",0.1,1000,null,"Chk1 inhibitor","Investigational (Ph 2)",null,null,"Selleck","S2626"]
["RAF265",0.1,1000,null,"C-Raf inhibitor","Investigational (Ph 2)",null,null,"Selleck","S2161"]
["Ralimetinib",1,10000,null,"p38MAPK inhibitor","Investigational (Ph 2)",null,null,"Selleck","S1494"]
["Raloxifene",1,10000,null,"Selective estrogen receptor modulator","Approved",null,null,"National Cancer Institute","NSC 747974-X/1"]
["RD162",1,10000,null,"AR antagonist","Probe","Inactive",null,"Axon Medchem","Axon 1532"]
["Rebastinib",0.1,1000,null,"Allosteric ABL, FLT3, TIE2, TRKA inhibitor","Investigational (Ph 1)","Inactive",null,"ChemieTek","CT-DCC20"]
["Refametinib",1,10000,null,"MEK1/2 inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-R119"]
["Regorafenib",1,10000,"Stivarga","B-Raf, c-Kit, VEGFR2 inhibitor","Approved",null,null,"Selleck","S1178"]
["Ridaforolimus",0.01,100,null,"binds FKBP12, causes inhibition of mTORC1","Investigational (Ph 3)",null,null,"Active Biochem","A-1004"]
["Rofecoxib",1,10000,"Vioxx","COX-2 inhibitor","Approved",null,null,"ChemieTek","CT-RX001"]
["Ruboxistaurin",1,10000,null,"PKCbeta inhibitor","Investigational (Ph 3)","Inactive",null,"Axon Medchem","Axon 1401-2"]
["Rucaparib",1,10000,null,"PARP inhibitor","Investigational (Ph 2)",null,null,"Axon Medchem","Axon 1529"]
["Ruxolitinib",1,10000,"Jakafi, Jakavi","JAK1&2 inhibitor","Approved",null,null,"ChemieTek","CT-INCB"]
["Saracatinib",1,10000,null,"Src, Abl inhibitor","Investigational (Ph 3)","Inactive",null,"LC Laboratories","S-8906"]
["SB 743921",0.01,100,null,"Mitotic inhibitor. Eg5/KSP inhibitor","Investigational (Ph 2)","Inactive",null,"Selleck","S2182"]
["SCH772984",1,10000,null,"ERK1 & 2 inhibitor","Probe",null,null,"ChemieTek","CT-SCH772"]
["Seliciclib",1,10000,null,"CDK2/7/9 inhibitor","Investigational (Ph 2)",null,null,"LC Laboratories","R-1234"]
["Selumetinib",1,10000,null,"MEK1/2 inhibitor","Investigational (Ph 3)",null,null,"Selleck","S1008"]
["Serdemetan",1,10000,null,"HDM2-p53 antagonist","Investigational (Ph 1)","Inactive",null,"Selleck","S1172"]
["SGC0946",1,10000,null,"DOT1L inhibitor","Probe","Inactive",null,"Selleck","S7079"]
["Simvastatin",1,10000,"Zocor","HMG CoA reductase inhibitor","Approved (non-oncology)",null,null,"Sigma-Aldrich","S6196"]
["Sirolimus",0.01,100,"Rapamune","binds FKBP12, causes inhibition of mTORC1","Approved",null,null,"LC Laboratories","R-5000"]
["SNS-032",1,10000,null,"CDK inhibitor","Investigational (Ph 2)","Inactive",null,"Selleck","S1145"]
["Sonidegib",1,10000,null,"Smothened (Hh) inhib","Investigational (Ph 2)",null,null,"ChemieTek","CT-LDE225"]
["Sonolisib",1,10000,null,"PI3K inhibitor, pan-class I. Irreversible","Investigational (Ph 2)",null,null,"Active Biochem","PX-866"]
["Sorafenib",0.1,1000,"Nevaxar","B-Raf, FGFR-1, VEGFR-2 & -3, PDGFR-beta, KIT, and FLT3 inhib","Approved",null,null,"LC Laboratories","S-8502"]
["Sotrastaurin",1,10000,null,"PKC inhibitor","Investigational (Ph 2)",null,null,"Axon Medchem","Axon 1635-2"]
["STA-21",3,30000,null,"STAT3 SH2 domain inhibitor","Probe",null,null,"Santa Cruz Biotechnology","sc-200757"]
["Stattic",5,50000,null,"STAT3 SH2 domain inhibitor","Probe","Inactive",null,"Tocris Biosciences","2798-3"]
["StemRegenin 1",1,10000,null,"AHR antagonist, stem cell regenerating","Probe","Inactive",null,"ChemieTek","CT-SR1"]
["Streptozocin",1,10000,null,"Alkylating glucosamine-nitrosourea agent","Approved",null,"Prodrug, activated in the liver","National Cancer Institute","NSC 37917-V/5"]
["Sunitinib",0.1,1000,"Sutent","Broad TK inhibitor","Approved",null,null,"LC Laboratories","S-8803"]
["Tacedinaline",0.1,1000,null,"HDAC inhibitor","Investigational (Ph 3)","Inactive",null,"LC Laboratories","C-2606"]
["Tacrolimus",1,10000,"Prograf, Advagraf, Protopic","Binds FKBP12, causes inhibition of calcineurin","Approved",null,null,"Tocris Biosciences","3631"]
["TAK-733",0.1,1000,null,"MEK1/2 inhibitor","Investigational (Ph 1)",null,null,"Selleck","S2617"]
["TAK-901",0.1,1000,null,"Aurora B inhibitor","Investigational (Ph 1)",null,null,"Selleck","S2718"]
["Tamatinib",1,10000,null,"Syk inhibitor","Investigational (Ph 1)","Inactive",null,"Selleck","S2194-2"]
["Tamoxifen",1,10000,null,"Estrogen receptor antagonist","Approved",null,"Prodrug, activated in the liver","National Cancer Institute","NSC 180973-S/203"]
["Tandutinib",0.1,1000,null,"FLT3, PDGFR, KIT inhibitor","Investigational (Ph 2)","Inactive",null,"LC Laboratories","T-7802"]
["Tanespimycin",1,10000,null,"HSP90 inhibitor","Investigational (Ph 2)",null,null,"Selleck","S1141"]
["Tarenflurbil",1,10000,null,"Gamma-secretase inhibitor","Investigational (Ph 3)","Inactive",null,"Cayman Chemical Company","70255"]
["Temozolomide",1,10000,null,"Alkylating agent","Approved",null,"Prodrug, activated in the liver","National Cancer Institute","NSC 362856-R/31"]
["Temsirolimus",0.01,100,"Torisel","binds FKBP12, causes inhibition of mTORC1","Approved",null,null,"LC Laboratories","T-8040"]
["Teniposide",1,10000,null,"Topoisomerase II inhibitor","Approved",null,null,"National Cancer Institute","NSC 122819-I/52"]
["TGX-221",1,10000,null,"PI3K beta selective inhibitor","Probe","Inactive",null,"ChemieTek","CT-TGX221"]
["Thalidomide",1,10000,null,"Immunosuppresant","Approved",null,null,"National Cancer Institute","NSC 66847-R/5"]
["Thio-TEPA",5,50000,null,"Alkylating agent","Approved",null,"Prodrug, activated in the liver","Sigma-Aldrich","T6069"]
["Thioguanine",1,10000,null,"Antimetabolite; Purine analog","Approved",null,"Prodrug, activated in the cells","National Cancer Institute","NSC 752-W/47"]
["Tipifarnib",1,10000,null,"Farnesyltransferase inhibitor","Investigational (Ph 3)",null,null,"Selleck","S1453"]
["Tivantinib",0.1,1000,null,"MET inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-ARQ197"]
["Tivozanib",1,10000,null,"VEGFR1, 2, 3, c-Kit, PDGFRB inhibitor","Investigational (Ph 3)",null,null,"ChemieTek","CT-AV951"]
["Tofacitinib",0.5,5000,"Xeljanz, Jakvinus","JAK3, JAK2(V617F) inhibitor","Approved",null,null,"LC Laboratories","T-1377"]
["Topotecan",1,10000,null,"Topoisomerase I inhibitor.  Camptothecin analog","Approved",null,null,"National Cancer Institute","NSC 609699-Y/16"]
["Toremifene",1,10000,"Fareston, Acapodene","selective estrogen receptor modulator","Approved",null,null,"Santa Cruz Biotechnology","sc-253712"]
["Tosedostat",1,10000,null,"Aminopeptidase inhibitor","Investigational (Ph 3)",null,null,"Tocris Biosciences","3595"]
["Trametinib",0.025,250,"Mekinist","MEK1/2 inhibitor","Approved",null,null,"ChemieTek","CT-GSK112"]
["Tretinoin",1,10000,null,"Retinoic acid receptor agonist","Approved",null,null,"National Cancer Institute","NSC 122758-Q/6"]
["Tubacin",1,10000,null,"HDAC6 inhibitor","Probe","Inactive",null,"Selleck","S2239"]
["Tubastatin A",1,10000,null,"HDAC6 inhibitor","Probe","Inactive",null,"ChemieTek","CT-TUBA"]
["UCN-01",1,10000,null,"PKCbeta, PDK1, Chk, Cdk2 inhibitor","Investigational (Ph 2)","Inactive",null,"Sigma-Aldrich","U6508-4"]
["UNC0638",1,10000,null,"G9a/GLP inhibitor","Probe","Inactive",null,"Tocris Biosciences","4343"]
["UNC0642",1,10000,null,"G9a/GLP inhibitor","Probe","Inactive",null,"Tocris Biosciences","5132"]
["UNC1215",2,30000,null,"L3MBTL3 inhibitor","Probe","Inactive",null,"Tocris Biosciences","4666"]
["Uramustine",1,10000,null,"Alkylating agent","Approved",null,"Prodrug, activated in the liver","National Cancer Institute","NSC 34462-Q/2"]
["Valproic acid",100,1000000,null,"HDAC inhibitor","Approved",null,null,"Sigma-Aldrich","P4543"]
["Valrubicin",0.5,5000,"Valstar","Topoisomerase II inhibitor","Approved",null,null,"National Cancer Institute","NSC 246131-R/4"]
["Vandetanib",0.1,1000,"Caprelsa","VEGFR,EGFR, RET inhibitor","Approved",null,null,"LC Laboratories","V-9402"]
["Varespladib",1,10000,null,"Secretory phospholipase A2 inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-VARE"]
["Vatalanib",1,10000,null,"VEGFR-1 & -2 inhibitor","Investigational (Ph 3)",null,null,"LC Laboratories","V-8303"]
["Veliparib",1,10000,null,"PARP inhibitor","Investigational (Ph 3)",null,null,"Selleck","S1004"]
["Vemurafenib",1,10000,"Zelboraf","B-Raf(V600E) inhibitor","Approved",null,null,"ChemieTek","CT-P4032"]
["Venetoclax",1,10000,"Venclexta","Bcl-2-selective inhibitor","Approved",null,null,"ChemieTek","CT-A199"]
["VER 155008",1,10000,null,"HSP70 inhibitor","Probe","Inactive",null,"Axon Medchem","Axon 1608"]
["Vinblastine",0.1,1000,null,"Mitotic inhibitor. Vinca alkaloid microtubule depolymerizer","Approved",null,null,"National Cancer Institute","NSC 49842-J44"]
["Vincristine",0.1,1000,null,"Mitotic inhibitor. Vinca alkaloid microtubule depolymerizer","Approved",null,null,"Selleck","S1241"]
["Vinorelbine",1,10000,null,"Mitotic inhibitor. Vinca alkaloid microtubule depolymerizer","Approved",null,null,"Selleck","S4269"]
["Vismodegib",1,10000,"Erivedge","Smothened (Hh) inhibitor","Approved",null,null,"LC Laboratories","V-4050"]
["Volasertib",0.1,1000,null,"PLK1 inhibitor","Investigational (Ph 3)",null,null,"ChemieTek","CT-BI6727"]
["Vorinostat",1,10000,"Zolinza","HDAC inhibitor","Approved",null,null,"LC Laboratories","V-8477"]
["Voxtalisib",1,10000,null,"mTOR/PI3K inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-XL765c"]
["VX-11E",0.25,2500,null,"ERK1 & 2 inhibitor","Probe","Inactive",null,"ChemieTek","CT-VX11e"]
["XAV-939",1,10000,null,"Tankyrase-1 and -2","Probe","Inactive",null,"Selleck","S1180"]
["YM155",1,10000,null,"Survivin inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-YM155"]
["ZSTK474",1,10000,null,"PI3K gamma selective inhibitor","Investigational (Ph 1)",null,null,"LC Laboratories","Z-1066"]
["KX2-391",1,10000,null,"non-ATP competitive Src inhibitor","Investigational (Ph 2)",null,null,"Selleck","S2700"]
["Omacetaxine",1,10000,null,"Protein synthesis inhib (80 S ribosome)","Approved",null,null,"Santa Cruz Biotechnology","sc-202652"]
["Icotinib",1,10000,null,"EGFR inhibitor","Investigational (Ph 2)"]

{"sheet":"62 compounds","index":1,"n_rows":65,"n_cols":10,"rows_kept":65,"cut":false,"hidden":false,"merged":[]}
["Supplementary Table 1B. Drug and compound collection used in the drug sensitvity and resistance testing assay"]
[]
["Drug_Name","start conc.","max. conc. Tested","Trade names","Mechanism/Targets","High phase/Approval status","Active/inactive in clinic","Prodrug Idenitifier","Supplier","Supplier Ref"]
["JQ1",1,10000,null,"BET family inhibitor","Probe","Inactive",null,"SGC","SGCBD01(+)"]
["AG490",10,100000,null,"JAK inhibitor","Probe",null,null,"Merck",658411]
["Alvocidib",1,10000,null,"CDK inhibitor","Investigational (Ph 2)",null,null,"Selleck","S1230"]
["Auranofin",0.25,2500,null,"Antirheumatic agent","Approved",null,null,"Sigma-Aldrich","A6733"]
["Axitinib",1,10000,"Inlyta","VEGFR, PDGFR, KIT inhibitor","Approved",null,null,"LC Laboratories","A-1107"]
["AZD1480",0.1,1000,null,"JAK1/2, FGFR inhibitor","Investigational (Ph 1)",null,null,"ChemieTek","CT-A1480"]
["AZD8055",1,10000,null,"mTOR inhibitor","Investigational (Ph 1)",null,null,"ChemieTek","CT-A8055-3"]
["BIIB021",1,10000,null,"HSP90 inhibitor","Investigational (Ph 2)","Inactive",null,"Selleck","S1175"]
["BMS-754807",1,10000,null,"IGF1R inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-BMS75"]
["Bosutinib",1,10000,"Bosulif","Abl, Src inhibitor","Approved",null,null,"LC Laboratories","B-1788"]
["Clomifene",1,10000,null,"Selective estrogen receptor modulator","Approved",null,null,"Selleck","S2561"]
["Crenolanib",1,10000,null,"PDGFRA and PDGFRB inhibitor","Investigational (Ph 2)",null,null,"Selleck","S2730"]
["Cyclophosphamide",4,40000,null,"Alkylating agent","Approved",null,"Prodrug, activated in the liver","Selleck","S1217"]
["Dactinomycin",0.1,1000,null,"RNA and DNA synthesis inhibitor","Approved",null,null,"National Cancer Institute","NSC 3053-Y/14"]
["Dactolisib",0.1,1000,null,"mTOR/(PI3K) inhibitor","Investigational (Ph 2)",null,null,"LC Laboratories","N-4288"]
["Danusertib",1,10000,null,"Aurora, Ret, TrkA, FGFR-1 inhibitor","Investigational (Ph 2)","Inactive",null,"Selleck","S1107"]
["Dexamethasone",1,10000,"Decadron, Dexpak","Immunosuppresant; glucocorticoid","Approved",null,null,"Selleck","S1322"]
["Everolimus",0.01,100,"Afinitor, Certican, Zortress","binds FKBP12, causes inhibition of mTORC1","Approved",null,null,"LC Laboratories","E-4040"]
["Fasudil",5,50000,null,"ROCK, PKA, PKG, PRK inhibitor, prodrug","Approved (Japan)",null,"Prodrug, activated in the liver","LC Laboratories","H-2330"]
["Fostamatinib",0.25,2500,null,"Syk inhibitor","Investigational (Ph 2)",null,null,"Selleck","S2206-3"]
["Galiellalactone",5,50000,null,"STAT3-DNA interaction inhibitor","Probe","Inactive",null,"Santa Cruz Biotechnology","sc-202165-6"]
["Gandotinib",1,10000,null,"JAK2 inhibitor","Investigational (Ph 2)","Inactive",null,"Selleck","S2179"]
["GDC-0068",1,10000,null,"Akt inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-G0068"]
["I-BET151",1,10000,null,"BET family inhibitor","Probe","Inactive",null,"ChemieTek","CT-BET151"]
["Icotinib",1,10000,null,"EGFR inhibitor","Investigational (Ph 2)",null,null,"Selleck","S2922"]
["Idelalisib",1,10000,"Zydelig","PI3K inhibitor, p110δ-selective","Approved",null,null,"ChemieTek","CT-CAL101"]
["INK128",0.1,1000,null,"mTOR inhibitor","Investigational (Ph 1)",null,null,"ChemieTek","CT-INK128"]
["KX2-391",1,10000,null,"non-ATP competitive Src inhibitor","Investigational (Ph 2)",null,null,"Selleck","S2700"]
["Lestaurtinib",0.1,1000,null,"FLT3, JAK2, TrkA, TrkB, TrkC inhibitor","Investigational (Ph 3)",null,null,"LC Laboratories","L-6307"]
["LLL12",3,30000,null,"STAT3 SH2 domain inhibitor","Probe",null,null,"Merck",573131]
["Luminespib ",0.1,1000,null,"HSP90 inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-AUY922"]
["Methotrexate",5,50000,null,"Antimetabolite; Anti-folate agent","Approved",null,null,"Selleck","S1210"]
["Methylprednisolone",1,10000,null,"Immunosuppressant","Approved",null,null,"Santa Cruz Biotechnology","sc-205749"]
["MK-2206",0.1,1000,null,"AKT inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-MK2206"]
["MK1775",1,10000,null,"Wee1 inhibitor","Investigational (Ph 2)",null,null,"Axon Medchem","Axon 1494"]
["Momelotinib",1,10000,null,"JAK1 & 2 inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-CYT387"]
["Navitoclax",1,10000,null,"Bcl-2/Bcl-xL inhibitor","Investigational (Ph 2)",null,null,"Selleck","S1001-2"]
["Omac§etaxine",1,10000,"Santa Cruz Biotechnology","Protein synthesis inhib (80 S ribosome)","Approved",null,null,"Santa Cruz Biotechnology","sc-202652"]
["Omipalisib",0.1,1000,null,"PI3K/mTOR inhibitor","Investigational (Ph 1)",null,null,"Selleck","S2658"]
["Palbociclib",1,10000,"Ibrance","CDK inhibitor (Cdk4/6)","Approved",null,null,"Selleck","S1116"]
["Panobinostat",0.1,1000,"Farydak, Faridak","HDAC inhibitor","Approved",null,null,"LC Laboratories","P-3703"]
["PF-04691502",1,10000,null,"PI3K/mTOR inhibitor","Investigational (Ph 2)",null,null,"ChemieTek","CT-PF1502"]
["PFI-1",1,10000,null,"Selective chemical probe for BET Bromodomains","Probe","Inactive",null,"SGC","SGCPFI"]
["Pictilisib",1,10000,null,"PI3K inhibitor, pan-class I","Investigational (Ph 2)",null,null,"LC Laboratories","G-9252"]
["Pimasertib",1,10000,null,"MEK1/2 inhibitor","Investigational (Ph 2)",null,null,"Selleck","S1475"]
["Ponatinib",0.1,1000,"Iclusig","Broad TK inhibitor","Approved",null,null,"Selleck","S1490"]
["Prednisolone",1,10000,null,"Immunomodulatory agent","Approved",null,null,"Santa Cruz Biotechnology","sc-205815"]
["Quisinostat",0.1,1000,null,"HDAC inhibitor","Investigational (Ph 2)",null,null,"Active Biochem","A-1162"]
["Regorafenib",1,10000,"Stivarga","B-Raf, c-Kit, VEGFR2 inhibitor","Approved",null,null,"Selleck","S1178"]
["Ruboxistaurin",1,10000,null,"PKCbeta inhibitor","Investigational (Ph 3)","Inactive",null,"Axon Medchem","Axon 1401-2"]
["Ruxolitinib",1,10000,"Jakafi, Jakavi","JAK1&2 inhibitor","Approved",null,null,"ChemieTek","CT-INCB"]
["Saracatinib",1,10000,null,"Src, Abl inhibitor","Investigational (Ph 3)","Inactive",null,"LC Laboratories","S-8906"]
["SNS-032",1,10000,null,"CDK inhibitor","Investigational (Ph 2)","Inactive",null,"Selleck","S1145"]
["Sorafenib",0.1,1000,"Nevaxar","B-Raf, FGFR-1, VEGFR-2 & -3, PDGFR-beta, KIT, and FLT3 inhib","Approved",null,null,"LC Laboratories","S-8502"]
["STA-21",3,30000,null,"STAT3 SH2 domain inhibitor","Probe",null,null,"Santa Cruz Biotechnology","sc-200757"]
["Stattic",5,50000,null,"STAT3 SH2 domain inhibitor","Probe","Inactive",null,"Tocris Biosciences","2798-3"]
["Tamatinib",1,10000,null,"Syk inhibitor","Investigational (Ph 1)","Inactive",null,"Selleck","S2194-2"]
["Temsirolimus",0.01,100,"Torisel","binds FKBP12, causes inhibition of mTORC1","Approved",null,null,"LC Laboratories","T-8040"]
["Tofacitinib",0.5,5000,"Xeljanz, Jakvinus","JAK3, JAK2(V617F) inhibitor","Approved",null,null,"LC Laboratories","T-1377"]
["UCN-01",1,10000,null,"PKCbeta, PDK1, Chk, Cdk2 inhibitor","Investigational (Ph 2)","Inactive",null,"Sigma-Aldrich","U6508-4"]
["Venetoclax",1,10000,"Venclexta","Bcl-2-selective inhibitor","Approved",null,null,"ChemieTek","CT-A199"]
["ZSTK474",1,10000,null,"PI3K gamma selective inhibitor","Investigational (Ph 1)",null,null,"LC Laboratories","Z-1066"]