{"text_format":"2","workbook":"xlsx","n_sheets":5,"sheets":["global","medIQR","quantile","cyclic_loess","super-delta"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"global","index":0,"n_rows":14,"n_cols":7,"rows_kept":14,"cut":false,"hidden":false,"merged":[]}
["Category","Term","Count","p-value","Benjamini adjusted p-value",null,"Comments"]
["KEGG_PATHWAY","Butanoate metabolism",7,0.031,0.4,null,"Common for all 5 procedures"]
["KEGG_PATHWAY","mismatch repair",8,0.0061,0.15]
["KEGG_PATHWAY","Valine, leucine and isoleucine degradation",8,0.088,0.69,null,"Only for global and medIQR normalization"]
["KEGG_PATHWAY","PPAR signaling pathway",9,0.064,0.6]
["KEGG_PATHWAY","Bladder Cancer",10,0.015,0.26]
["KEGG_PATHWAY","Glycolysis/Gluconeogenesis",11,0.0058,0.17]
["KEGG_PATHWAY","DNA replication",13,7.5E-005,0.0062,"***"]
["KEGG_PATHWAY","P53 signaling pathway",13,0.0099,0.21]
["KEGG_PATHWAY","Progesterone-mediated oocyte maturation",14,0.0035,0.14]
["KEGG_PATHWAY","Small cell lung cancer",14,0.018,0.29]
["KEGG_PATHWAY","Purine metabolism",18,0.039,0.45]
["KEGG_PATHWAY","Oocyte meiosis",21,0.0001,0.0056,"***"]
["KEGG_PATHWAY","Cell cycle",40,3.2E-013,5.2E-011,"***"]

{"sheet":"medIQR","index":1,"n_rows":14,"n_cols":7,"rows_kept":14,"cut":false,"hidden":false,"merged":[]}
["Category","Term","Count","p-value","Benjamini adjusted p-value",null,"Comments"]
["KEGG_PATHWAY","Butanoate metabolism",7,0.029,0.38,null,"Common for all 4 procedures"]
["KEGG_PATHWAY","mismatch repair",8,0.0056,0.14]
["KEGG_PATHWAY","Valine, leucine and isoleucine degradation",8,0.082,0.66,null,"Only for global and medIQR normalization"]
["KEGG_PATHWAY","PPAR signaling pathway",9,0.059,0.6]
["KEGG_PATHWAY","Bladder Cancer",10,0.013,0.27]
["KEGG_PATHWAY","Glycolysis/Gluconeogenesis",11,0.0052,0.16]
["KEGG_PATHWAY","P53 signaling pathway",12,0.023,0.34]
["KEGG_PATHWAY","DNA replication",13,6.4E-005,0.0053,"***"]
["KEGG_PATHWAY","Progesterone-mediated oocyte maturation",14,0.0031,0.12]
["KEGG_PATHWAY","Small cell lung cancer",14,0.016,0.28]
["KEGG_PATHWAY","Purine metabolism",17,0.064,0.6]
["KEGG_PATHWAY","Oocyte meiosis",21,8.1E-005,0.0045,"***"]
["KEGG_PATHWAY","Cell cycle",40,1.8E-013,3E-011,"***"]

{"sheet":"quantile","index":2,"n_rows":14,"n_cols":7,"rows_kept":14,"cut":false,"hidden":false,"merged":[]}
["Category","Term","Count","p-value","Benjamini adjusted p-value",null,"Comments"]
["KEGG_PATHWAY","Butanoate metabolism",6,0.097,0.73,null,"Common for all 4 procedures"]
["KEGG_PATHWAY","mismatch repair",8,0.0064,0.16]
["KEGG_PATHWAY","PPAR signaling pathway",9,0.067,0.65]
["KEGG_PATHWAY","Bladder Cancer",10,0.016,0.31]
["KEGG_PATHWAY","Pathogenic Escherichia coli infection",10,0.081,0.69,null,"Unique for quantile and cyclic-loess normalization"]
["KEGG_PATHWAY","Glycolysis/Gluconeogenesis",11,0.0062,0.19]
["KEGG_PATHWAY","P53 signaling pathway",12,0.027,0.37]
["KEGG_PATHWAY","DNA replication",13,8.3E-005,0.0069,"***"]
["KEGG_PATHWAY","Progesterone-mediated oocyte maturation",14,0.0038,0.15]
["KEGG_PATHWAY","Small cell lung cancer",14,0.02,0.34]
["KEGG_PATHWAY","Purine metabolism",19,0.022,0.34]
["KEGG_PATHWAY","Oocyte meiosis",21,0.00012,0.0065,"***"]
["KEGG_PATHWAY","Cell cycle",40,4.4E-013,7.3E-011,"***"]

{"sheet":"cyclic_loess","index":3,"n_rows":17,"n_cols":7,"rows_kept":17,"cut":false,"hidden":false,"merged":[]}
["Category","Term","Count","p-value","Benjamini adjusted p-value",null,"Comments"]
["KEGG_PATHWAY","Butanoate metabolism",7,0.033,0.43,null,"Common for all 5 procedures"]
["KEGG_PATHWAY","Mismatch repair",8,0.0068,0.15]
["KEGG_PATHWAY","Valine, leucine and isoleucine degradation",8,0.095,0.64]
["KEGG_PATHWAY","PPAR signaling pathway",9,0.07,0.63]
["KEGG_PATHWAY","Pathogenic Escherichia coli infection",10,0.085,0.65,null,"Unique for quantile and cyclic-loess normalization"]
["KEGG_PATHWAY","Bladder cancer",11,0.0053,0.16]
["KEGG_PATHWAY","Glycolysis / Gluconeogenesis",11,0.0066,0.17]
["KEGG_PATHWAY","DNA replication",13,9.1E-005,0.0075,"***"]
["KEGG_PATHWAY","P53 signaling pathway",13,0.011,0.21]
["KEGG_PATHWAY","Calcium signaling pathway",13,0.094,0.66,null,"Unique"]
["KEGG_PATHWAY","Progesterone-mediated oocyte maturation",14,0.0042,0.16]
["KEGG_PATHWAY","Small cell lung cancer",14,0.021,0.32]
["KEGG_PATHWAY","Purine metabolism",18,0.046,0.51]
["KEGG_PATHWAY","Oocyte meiosis",21,0.00013,0.0074,"***"]
["KEGG_PATHWAY","Pathways in cancer",32,0.081,0.66,null,"Unique"]
["KEGG_PATHWAY","Cell cycle",41,1.1E-013,1.8E-011,"***"]

{"sheet":"super-delta","index":4,"n_rows":15,"n_cols":7,"rows_kept":15,"cut":false,"hidden":false,"merged":[]}
["Category","Term","Count","p-value","Benjamini adjusted p-value",null,"Comments"]
["KEGG_PATHWAY","Biosynthesis of unsaturated fatty acids",6,0.06,0.66,null,"Unique for super-delta"]
["KEGG_PATHWAY","Butanoate metabolism",7,0.06,0.63,null,"Common for all 4 procedures"]
["KEGG_PATHWAY","Type II diabetes mellitus",7,0.089,0.71,null,"Unique for super-delta"]
["KEGG_PATHWAY","mismatch repair",8,0.014,0.3]
["KEGG_PATHWAY","PPAR signaling pathway",10,0.062,0.6]
["KEGG_PATHWAY","Bladder Cancer",11,0.014,0.34]
["KEGG_PATHWAY","Glycolysis/Gluconeogenesis",12,0.0059,0.23]
["KEGG_PATHWAY","DNA replication",13,0.00036,0.031,"**"]
["KEGG_PATHWAY","p53 signaling pathway",14,0.014,0.38]
["KEGG_PATHWAY","Progesterone-mediated oocyte maturation",14,0.014,0.38]
["KEGG_PATHWAY","Small cell lung cancer",15,0.028,0.46]
["KEGG_PATHWAY","Purine metabolism",20,0.045,0.59]
["KEGG_PATHWAY","Oocyte meiosis",21,0.0009,0.051,"*"]
["KEGG_PATHWAY","Cell cycle",42,2.6E-012,4.5E-010,"***"]