Hepatocyte-specific deletion of BAP31 promotes SREBP1C activation, promotes hepatic lipid accumulation, and worsens IR in mice

Supplemental Data

• cover letter with response to comments (.docx, 102 KB) - cover letter with response to comments
• Supplemental Figure S1 (.docx, 384 KB) - Supplemental Figure S1. Generation of BAP31 floxed mice.
• Supplemental Figure S2. (.docx, 3.3 MB) - Supplemental Figure S2. BAP31-deletion in hepatocytes increases body weight gain and liver weight in mice fed high-fat diet for 36 days.
• Supplemental Figure S3. (.docx, 3.4 MB) - Supplemental Figure S3. BAP31-deletion in hepatocytes increases hepatic triglycerides in mice fed high-fat diet for 36 days.
• Supplemental Figure S4. (.docx, 1.2 MB) - Supplemental Figure S4. BAP31-deletion in hepatocytes increases lipogenic gene expression in lives from mice fed high-fat diet for 36 days.
• Supplemental Figure S5. (.docx, 3.9 MB) - Supplemental Figure S5. BAP31-deletion in hepatocytes fails to modulate Akt phosphorylation in white adipose tissue.
• Supplemental Figure S6. (.docx, 3.5 MB) - Supplemental Figure S6. BAP31-deletion in hepatocytes increases white adipose tissue mass in mice fed high-fat diet for 36 days.
• Supplemental Figure S7. (.docx, 17.3 MB) - Supplemental Figure S7. BAP31-deletion in hepatocytes increases white adipose tissue mass in mice fed high-fat diet for 96 days.
• Supplemental Figure S8. (.docx, 2.4 MB) - Supplemental Figure S8. The transcription levels of genes in white adipose tissue from WT and MT mice fed the standard chow diet or high-fat diet for 96 days.
• Supplemental materials (.docx, 12 KB) - Supplemental materials Targeting construct and targeting procedure for the generation of BAP31 floxed mice.
• Supplemental Table S1 (.docx, 18 KB) - Supplementary Table 1. Primer sequences for real-time PCR
• Supplemental Table S2 (.docx, 14 KB) - Supplemental Table S2: List of antibodies used in this study