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{"sheet":"Clinicopathological data","index":0,"n_rows":112,"n_cols":36,"rows_kept":112,"cut":false,"hidden":false,"merged":[]}
["Supplemental Table S2. Clinicopathological data."]
[]
["PatientID","EAD","AgeAtSurgery (years)","iPSA (ng/mL)","cT","cTcoded","GleasonSumBiopsy","GleasonSumBiopsyDetail","GleasonSumBiopsyCoded","NbPosBiopsies","TotalNbBiopsies","RiskClassEAU","RiskClassDAmico","GleasonSumRP","GleasonSumRPDetail","GleasonSumRPCoded","pT","pTcoded","pN","nLN","nLN1","MaxTypeLN1","TumorVolcc","TumorVolPCT","SurgialMargin","SVInvasion","CapsInvasion","CapsBreakthrough","BVInvasion","PNInvasion","BiochemRelapse","TimeToBCR(months)","ClinicalFailure","TimeToCF(months)","Death","DeathRemark"]
[1476467,88800685,51.775342465753425,10.44,"2c",0,6,"3+3",0,3,10,2,2,7,"3+4",0,"2c",0,0,22,0,0,2.0499999999999998,3.47,0,0,0,0,0,1,0,63.978082191780814,0,63.978082191780814]
[1479754,88904016,73.917808219178085,8.24,"2c",0,7,"3+4",0,3,10,1,2,7,"4+3",0,"2c",0,1,42,1,1,0.86,0.88,1,1,0,0,0,1,0,72.164383561643831,0,72.164383561643831]
[1482057,75396168,73.158904109589045,3.3,"3a",1,7,"3+4",0,3,3,2,2,7,"3+4",0,"3a",1,0,30,0,0,2.69,7.09,0,0,1,1,0,1,0,72.164383561643831,0,72.164383561643831,0]
[1483520,73533002,68.580821917808223,1.49,"3a",1,8,"4+4",1,7,10,2,2,7,"4+3",0,"3a",1,0,22,0,0,0.91,3.65,0,0,1,1,0,1,1,17.621917808219177,0,77.68767123287671,0]
[1483737,84335207,66.936986301369856,5.2,"3a",1,7,"3+4",0,4,10,2,2,7,"4+3",0,"2c",0,0,32,0,0,2.34,7.3,0,0,0,0,0,1,0,57.731506849315068,0,57.731506849315068,0]
[1485659,84745918,66.112328767123287,9.8000000000000007,"3a",1,7,"4+3",0,1,8,2,2,7,"4+3",0,"3a",1,1,26,4,4,2.13,8.52,0,0,1,1,0,1,0,74.432876712328778,0,74.432876712328778,0]
[1486313,71852172,73.61643835616438,8.1300000000000008,"2c",0,7,"3+4",0,2,2,2,2,7,"4+3",0,"2c",0,1,25,1,2,5.37,5.42,0,0,1,0,0,1,0,53.983561643835621,0,53.983561643835621,0]
[1487875,62040738,55.586301369863016,6.25,"4a",1,7,"4+3",0,6,6,2,2,9,"4+5",1,"3b",1,1,32,9,4,16.28,37,1,1,1,1,0,1,1,23.835616438356162,0,74.465753424657535,0]
[1489718,83460394,62.115068493150687,7.6,"2c",0,9,"5+4",1,9,10,2,2,7,"4+3",0,"3a",1,0,33,0,0,2.21,6.1,0,0,1,1,0,1,0,75.386301369863006,0,75.386301369863006,0]
[1491118,87407326,63.983561643835614,57,"3a",1,7,"3+4",0,2,2,2,2,7,"4+3",0,"2c",0,0,21,0,0,10.71,15.75,0,0,0,0,0,1,1,40.635616438356166,0,40.635616438356166,0]
[1491247,71278345,57.273972602739725,9.6999999999999993,"3a",1,8,"3+4+5",1,2,6,2,2,8,"4+4",1,"2c",0,1,13,1,4,1.34,2.98,0,0,0,0,0,1,1,5.4575342465753423,0,5.4575342465753423,0]
[1495655,85940310,60.936986301369863,21.75,"3a",1,8,"4+4",1,2,2,2,2,8,"4+4",1,"3a",1,1,18,6,4,4.62,3.53,1,1,1,1,1,1,0,73.841095890410969,0,73.841095890410969,0]
[1495834,62122023,58.624657534246573,70.89,"2c",0,7,"3+4",0,12,24,2,2,7,"4+3",0,"4a",1,0,11,0,0,9.8800000000000008,19.38,1,1,1,1,0,0,0,71.736986301369868,0,71.736986301369868,0]
[1496112,62301353,64.115068493150687,24.89,"3a",1,5,"3+2",0,1,2,2,2,8,"4+4",1,"2b",0,0,11,0,0,1.3,4.3499999999999996,0,0,0,0,0,1,0,26.926027397260274,0,26.926027397260274,0]
[1497222,62208202,60.589041095890408,3.1,"3a",1,7,"3+4",0,2,10,2,2,7,"4+3",0,"3a",1,0,10,0,0,0.91,2.83,0,0,0,0,0,1,1,65.39178082191782,0,73.117808219178073,0]
[1498805,80003395,62.797260273972604,10.6,"3b",1,7,"3+4",0,2,2,2,2,8,"4+4",1,"3b",1,1,20,2,4,11.73,25.49,0,0,1,1,0,1,0,60.065753424657537,0,60.065753424657537,0]
[1502769,87457776,60.506849315068493,8.67,"3a",1,7,"3+4",0,1,4,2,2,7,"4+3",0,"2c",0,1,20,1,3,0.99,1.87,0,0,1,0,0,1,0,70.093150684931516,0,70.093150684931516,0]
[1503477,76518885,66.964383561643842,8.23,"3a",1,8,"4+4",1,7,10,2,2,9,"4+5",1,"3a",1,1,19,3,4,3.54,8.6300000000000008,0,0,1,1,0,1,0,67.561643835616437,0,67.561643835616437,0]
[1504502,76153501,60.578082191780823,6.8,"3a",1,8,"4+4",1,1,2,2,2,9,"4+5",1,"3b",1,1,24,2,3,7.6,13.6,0,0,1,1,0,1,0,69.863013698630141,1,67.660273972602738,0]
[1505425,62451778,53.641095890410959,14.9,"3a",1,7,"4+3",0,5,9,2,2,7,"4+3",0,"3a",1,1,21,2,2,10.59,24.06,0,0,1,1,0,1,0,21.172602739726027,0,21.172602739726027,0]
[1508582,80178007,49.230136986301368,12.3,"1c",0,7,"4+3",0,1,10,1,1,7,"3+4",0,"2c",0,1,16,1,2,1.1000000000000001,1.97,0,0,0,0,0,1,0,64.602739726027394,0,64.602739726027394,0]
[1509407,83919605,70.290410958904104,12.4,"3b",1,9,"4+5",1,5,6,2,2,9,"4+5",1,"3b",1,1,23,4,4,5.8,16,0,0,1,1,0,1,0,63.846575342465755,0,63.846575342465755,0]
[1510542,74511700,72.361643835616434,46.75,"2c",0,7,"4+3",0,8,10,2,2,7,"4+3",0,"2c",0,0,21,0,0,9.6300000000000008,16.05,0,0,0,0,0,1,1,24.887671232876713,0,69.271232876712332,0]
[1511701,78519204,73.287671232876718,10.6,"3a",1,8,"4+4",1,2,10,2,2,8,"4+4",1,"3b",1,1,17,2,2,2.36,1.67,0,0,1,1,0,1,0,66.575342465753437,0,66.575342465753437,0]
[1515054,82803594,69.947945205479456,13.3,"3a",1,9,"4+5",1,5,8,2,2,9,"4+5",1,"3b",1,1,23,4,4,6.5,12.5,0,0,1,1,0,1,0,67.528767123287665,0,67.528767123287665,0]
[1522499,62747894,68.336986301369862,12.99,"3a",1,9,"4+5",1,2,4,2,2,9,"4+5",1,"4a",1,0,13,0,0,3.37,7.33,1,1,1,1,0,1,0,65.490410958904107,0,65.490410958904107,0]
[1522678,74581711,68.61917808219178,11.35,"2c",0,8,"3+4+5",1,2,7,2,2,9,"4+5",1,"2c",0,0,35,0,0,1.72,3.6,0,0,0,0,0,1,0,65.68767123287671,0,65.68767123287671,0]
[1524834,74663162,71.517808219178079,10.4,"2c",0,7,"3+4",0,8,8,1,2,7,"3+4",0,"2c",0,0,16,0,0,1.85,6.6,0,0,0,0,0,1,0,63.945205479452056,0,63.945205479452056,0]
[1525881,78158821,67.961643835616442,5.8,"3a",1,8,"4+4",1,5,10,2,2,7,"4+3",0,"3b",1,1,19,2,3,5.05,20.21,0,0,1,1,1,1,0,63.747945205479454,0,63.747945205479454,0]
[1527150,80991458,57.917808219178085,14.4,"3a",1,7,"4+3",0,5,10,2,2,7,"4+3",0,"3a",1,1,19,3,2,4.07,10.43,1,1,1,1,0,1,1,45.764383561643832,0,60.263013698630132,0]
[1529453,62883830,64.756164383561639,10.14,"3a",1,8,"4+4",1,3,6,2,2,9,"5+4",1,"3a",1,0,22,0,0,4.3,10.57,1,1,1,1,0,1,0,2.1041095890410961,0,2.1041095890410961,0]
[1530369,63028898,62.871232876712327,13.8,"3a",1,7,"4+3",0,3,6,2,2,7,"4+3",0,"3a",1,0,13,0,0,3.03,4.74,0,0,1,1,0,1,0,62.104109589041101,0,62.104109589041101,0]
[1535211,75940098,55.150684931506852,8.23,"3a",1,7,"3+4",0,7,11,2,2,7,"3+4",0,"2c",0,0,16,0,0,4.21,7.02,0,0,0,0,1,1,0,56.31780821917809,0,56.31780821917809,0]
[1535318,83430702,69.260273972602747,13.5,"3a",1,9,"4+5",1,4,10,2,2,8,"4+4",1,"3b",1,1,10,1,2,1.72,5.05,0,0,0,0,0,1,0,59.145205479452059,0,59.145205479452059,0]
[1535493,63158729,72.649315068493152,23,"2c",0,8,"4+4",1,16,20,2,2,7,"4+3",0,"2c",0,0,12,0,0,8.83,17.649999999999999,1,1,0,0,0,1,0,60.756164383561639,0,60.756164383561639,0]
[1536075,88365424,68.421917808219177,8.2799999999999994,"3a",1,7,"4+3",0,3,6,2,2,7,"4+3",0,"2c",0,0,7,0,0,0.99,2.99,0,0,0,0,0,1,0,9.3041095890410972,0,9.3041095890410972,0]
[1536812,62882808,51.92876712328767,11,"3a",1,7,"4+3",0,4,8,2,2,7,"4+3",0,"3a",1,0,14,0,0,3.03,8.65,0,0,1,1,1,1,0,59.473972602739728,0,59.473972602739728,0]
[1539103,74491184,72.904109589041099,16,"3a",1,7,"4+3",0,6,10,2,2,9,"4+5",1,"3b",1,1,22,4,4,5.71,10.199999999999999,0,0,1,1,0,1,0,56.580821917808223,0,56.580821917808223,0]
[1539731,71822480,72.38356164383562,3.34,"3a",1,7,"3+4",0,4,10,2,2,7,"3+4",0,"2c",0,0,20,0,0,2.29,2.9,0,0,0,0,0,1,0,59.506849315068493,0,59.506849315068493,0]
[1539913,79841573,69.671232876712324,15.47,"3b",1,7,"4+3",0,4,4,2,2,9,"4+5",1,"3b",1,1,19,2,4,23.96,36.86,0,0,1,1,0,0,1,3.3205479452054791,0,50.038356164383558,0]
[1540696,84769009,58.665753424657531,5.37,"3a",1,7,"3+4",0,2,2,2,2,7,"4+3",0,"2c",0,0,22,0,0,1.89,3.05,0,0,0,0,0,1,0,54.312328767123283,0,54.312328767123283,0]
[1542525,76979160,52.150684931506852,10.79,"3a",1,8,"4+4",1,6,10,2,2,7,"4+3",0,"2c",0,0,23,0,0,2.64,10.57,0,0,0,0,0,1,0,58.224657534246575,0,58.224657534246575,0]
[1543171,78237617,54.939726027397263,14.97,"3a",1,7,"4+3",0,4,10,2,2,7,"3+4",0,"2c",0,1,27,1,4,3.08,6.41,1,1,0,0,0,1,0,59.342465753424655,0,59.342465753424655,0]
[1543862,63272397,71.232876712328761,12.8,"3a",1,8,"4+4",1,1,1,2,2,7,"4+3",0,"3a",1,0,20,0,0,2.09,6.15,0,0,1,1,0,1,0,6.5753424657534254E-2,0,6.5753424657534254E-2,1,"not PCa related"]
[1545275,80532807,65.879452054794527,5.07,"3a",1,7,"3+4",0,1,1,2,2,7,"3+4",0,"3a",1,0,17,0,0,2.6,6.84,1,1,1,1,0,1,0,54.246575342465761,0,54.246575342465761,0]
[1547305,70272265,66.090410958904116,11,"3a",1,8,"4+4",1,5,10,2,2,8,"4+4",1,"3a",1,1,15,1,3,4.0199999999999996,7.45,0,0,1,1,0,1,0,53.884931506849313,0,53.884931506849313,0]
[1547752,63046031,71.668493150684938,18.53,"3a",1,7,"3+4",0,4,6,2,2,7,"4+3",0,"2c",0,0,21,0,0,3,7.13,0,0,0,0,0,1,0,48.263013698630132,0,48.263013698630132,0]
[1549171,88637194,59.553424657534244,14,"2c",0,8,"4+4",1,8,10,2,2,7,"3+4",0,"2c",0,0,13,0,0,6.41,13.64,0,0,0,0,0,1,0,53.852054794520548,0,53.852054794520548,0]
[1550968,63199970,58.235616438356168,20,"3b",1,7,"4+3",0,8,14,2,2,8,"4+4",1,"3b",1,1,10,4,3,6.78,15.06,1,1,1,1,1,1,0,52.471232876712335,0,52.471232876712335,0]
[1555736,78147246,71.92876712328767,3.39,"3a",1,6,"3+3",0,1,1,2,2,7,"3+4",0,"2c",0,0,7,0,0,1.06,3.78,0,0,0,0,0,1,0,55.857534246575341,0,55.857534246575341,0]
[1559226,63601553,55.534246575342465,8.8000000000000007,"2b",0,7,"3+4",0,7,10,1,1,7,"3+4",0,"3a",1,1,21,4,2,3.85,9.18,1,1,1,1,0,1,1,10.75068493150685,0,54.279452054794525,0]
[1561397,75961714,72.802739726027397,4.21,"2b",0,9,"5+4",1,2,2,2,2,9,"4+5",1,"2c",0,0,12,0,0,0.46,2.5499999999999998,0,0,0,0,0,1,0,49.906849315068484,0,49.906849315068484,0]
[1561681,63816490,58.531506849315072,8,"3b",1,9,"4+5",1,4,16,2,2,9,"4+5",1,"3b",1,1,17,1,0,2.82,7.85,0,0,1,1,1,1,1,30.410958904109588,1,30.410958904109588,0]
[1563740,87882940,66.991780821917814,5.59,"3b",1,7,"3+4",0,7,10,2,2,7,"3+4",0,"2c",0,0,19,0,0,4.28,13.23,0,0,0,0,0,1,0,46.257534246575347,0,46.257534246575347,0]
[1565813,83269605,64.671232876712324,7.8,"3a",1,7,"3+4",0,4,10,2,2,7,"3+4",0,"2c",0,0,27,0,0,1.58,5.25,0,0,0,0,0,1,0,10.093150684931507,0,10.093150684931507,0]
[1568572,63766802,65.983561643835614,9.5,"3a",1,7,"3+4",0,1,11,2,2,7,"3+4",0,"2c",0,0,28,0,0,3.64,5.35,0,0,0,0,0,0,0,47.802739726027397,0,47.802739726027397,0]
[1569377,87483459,60.389041095890413,9,"3a",1,7,"4+3",0,6,11,2,2,7,"4+3",0,"3b",1,1,13,1,2,3.55,7.09,0,0,0,0,0,1,0,50.531506849315065,0,50.531506849315065,0]
[1570041,88031430,71.063013698630144,7.8,"3a",1,8,"4+4",1,3,10,2,2,9,"4+5",1,"3a",1,1,15,1,3,4.22,10.56,0,0,1,1,0,1,1,41.227397260273975,0,46.684931506849317,0]
[1572125,64489263,69.246575342465746,11.4,"3b",1,9,"4+3+5",1,2,2,2,2,9,"4+5",1,"3b",1,1,21,8,4,9.57,21.27,1,1,1,1,1,1,0,37.709589041095889,0,37.709589041095889,0]
[1572263,83610071,62.443835616438356,8.8000000000000007,"2c",0,9,"4+5",1,7,10,2,2,8,"4+4",1,"3b",1,1,13,1,1,3.49,6.12,0,0,1,1,0,1,0,43.956164383561642,0,43.956164383561642,0]
[1572673,87395240,67.136986301369859,11.7,"3b",1,8,"4+4",1,4,10,2,2,8,"4+4",1,"3a",1,1,39,2,4,1.36,5.05,0,0,1,1,0,1,1,49.446575342465749,0,50.564383561643837,0]
[1574337,63825590,60.936986301369863,7.39,"2b",0,8,"5+3",1,4,10,2,2,7,"3+4",0,"2c",0,0,28,0,0,0.38,0.94,0,0,0,0,0,0,0,49.709589041095889,0,49.709589041095889,0]
[1576509,88062773,62.504109589041093,6.34,"3a",1,7,"3+4",0,5,10,2,2,7,"3+4",0,"3a",1,0,26,0,0,4.24,12.57,0,0,1,1,0,1,0,43.791780821917811,0,43.791780821917811,0]
[1577828,79068789,66.556164383561651,10,"2c",0,8,"4+4",1,9,10,2,2,7,"4+3",0,"2c",0,0,25,0,0,2.5299999999999998,6.67,0,0,0,0,0,1,0,49.019178082191786,0,49.019178082191786,0]
[1577968,83160002,67.646575342465752,6.01,"3b",1,10,"5+5",1,9,10,2,2,10,"5+5",1,"3b",1,1,24,10,4,11.85,28.89,1,1,1,1,0,1,1,40.536986301369865,1,29.753424657534246,0]
[1580130,87937041,57.139726027397259,13.8,"3b",1,7,"4+3",0,7,10,2,2,8,"4+4",1,"3b",1,1,29,5,4,8.59,19.09,0,0,1,1,0,1,0,47.901369863013699,0,47.901369863013699,0]
[1583336,64647480,68.30958904109589,11.24,"2c",0,8,"4+4",1,3,10,2,2,8,"4+4",1,"2c",0,0,25,0,0,1.49,1.74,0,0,0,0,0,1,0,22.652054794520545,0,22.652054794520545,0]
[1584666,73020349,55.054794520547944,7.4,"3b",1,7,"3+4",0,3,3,2,2,8,"4+4",1,"2c",0,1,49,2,4,1.44,3.12,0,0,0,0,1,1,1,44.580821917808215,0,45.698630136986303,0]
[1585509,73675951,66.68767123287671,5.04,"3a",1,7,"3+4",0,4,10,2,2,7,"4+3",0,"3b",1,1,34,3,2,8.83,18.03,0,0,1,1,1,1,0,38.761643835616439,0,38.761643835616439,0]
[1592758,82803339,60.482191780821921,13.2,"2a",0,9,"4+5",1,1,11,2,2,9,"4+5",1,"2b",0,0,42,0,0,0.32,0.38,0,0,0,0,0,1,0,42.575342465753423,0,42.575342465753423,0]
[1592915,80157977,67.37534246575342,9.1199999999999992,"3a",1,7,"4+3",0,7,10,2,2,7,"3+4",0,"2c",0,0,41,0,0,3.59,8.36,0,0,1,0,0,1,0,43.693150684931503,0,43.693150684931503,0]
[1593046,87335832,73.161643835616445,12.5,"3a",1,9,"4+5",1,7,10,2,2,9,"5+4",1,"3b",1,1,42,3,2,7.28,19.8,1,1,1,1,1,1,0,42.673972602739724,0,42.673972602739724,0]
[1593507,64743230,69.975342465753428,12,"2c",0,7,"3+4",0,6,10,1,2,7,"3+4",0,"2c",0,0,29,0,0,2.93,6.11,0,0,0,0,0,1,0,40.668493150684931,0,40.668493150684931,0]
[1593624,82775339,67.032876712328772,12.8,"3a",1,9,"4+3+5",1,8,8,2,2,8,"4+4",1,"3a",1,1,28,1,1,5.34,14.06,1,1,1,0,0,1,0,40.898630136986306,0,40.898630136986306,0]
[1594321,62789334,69.320547945205476,25,"2a",0,9,"4+5",1,7,11,2,2,9,"4+5",1,4,1,1,34,3,4,3.49,8.7200000000000006,0,0,1,1,1,1,0,41.161643835616438,0,41.161643835616438,0]
[{"$nulls":17},{"$f":"SUM(R4:R78)","v":42}]
["iPSA","initial (before therapy) prostate-specific antigen serum levels"]
["cT","Clinical T(umor)-stage"]
["cTcoded","cT Low: cT≤2 = 0; cT High: cT>2 = 1"]
["GleasonSumBiopsy","GleasonSum as defined on prostate biopsies (before surgery)"]
["GleasonSumBiopsyDetail","Sum of primary and secondary (sometimes tertiary) Gleason grades"]
["GleasonSumBiopsyCoded","GleasonSum Biopsies Low ≤ 7 = 0; GleasonSum Biopsies High > 7 = 1"]
["NbPosBiopsies","Number of positive biopsies"]
["TotalNbBiopsies","Total number of biopsies"]
["RiskClassEAU","Risk classification according to the EAU guidelines; 1 = intermediate risk; 2 = high risk"]
["RiskClassDAmico","Risk classification according to D'Amico; 1 = intermediate risk; 2 = high risk"]
["GleasonSumRP","GleasonSum as defined on resection specimen (aftersurgery)"]
["GleasonSumRPDetail","Sum of primary and secondary (sometimes tertiary) Gleason grades as defined on resection specimen (after surgery)"]
["GleasonSumRPCoded","GleasonSum resection specimen Low ≤ 7 = 0; GleasonSum resection specimen High >7 = 1"]
["pT","Pathological T(umor)-stage"]
["pTcoded","pT Low: pT≤2 = 0; pT High: pT>2 = 1"]
["pN","pathological Nodal status; 0 = negative (no affected lymph nodes); 1 = positive (affected lymph nodes)"]
["nLN","Total number of lymph nodes removed during surgery"]
["nLN1","Number of positive lymph nodes removed during surgery"]
["MaxTypeLN1","Metastases in the lymph nodes are divided into several subcategories depending on their size (diameter)"]
[null,"Isolated tumor cells (ITC) <0,2mm = 1; micrometastases (micro) <2mm = 2; macrometastases (macro) >2mm = 3; macrometastases with extracapsular extension  (macro+ECE) = 4"]
["TumorVolcc","Tumor volume in cc"]
["TumorVolPCT","Tumor volume in percentage"]
["SurgicalMargin","0= negative (better outcome); 1 = positive (worse outcome)"]
["SVInvasion","Seminal vesicle invasion; 0 = no; 1 = yes"]
["CapsInvasion","Capsular invasion; 0 = no; 1 = yes"]
["CapsBreakthrough","Capsular Breakthrough; 0 = no; 1 = yes"]
["BVInvasion","Blood vessel invasion; 0 = no; 1 = yes"]
["PNInvasion","perineural invasion; 0 = no; 1 = yes"]
["BiochemRelapse","Biochemical relapse (BCR); 0 = no; 1 = yes"]
["TimeToBCR(months)","Time to biochemical relapse in months"]
["ClincialFailure","Clinical failure, i.e. Could tumor recurrence be detected by means of imaging; 0 = no; 1 = yes"]
["TimeToCF(months)","Time to clinical failure in months"]
["Death","Has the patient died?; 0 = no; 1 = yes"]