,,,Serum Hcys (log-transformed),,,,,,,,Urinary %InAs,,,,,,Urinary %MMA,,,,,,Urinary %DMA,,,,
Gene,LD block,SNP,Beta,SE,CL95_L,CL95_H,pvalue,FDR1,FDR2,,B,SE,pvalue,FDR1,FDR2,,B,SE,pvalue,FDR1,FDR2,,B,SE,pvalue,FDR1,FDR2
AS3MT,1,rs10748835,-0.00516892,0.016740932,-0.03801381,0.02767597,0.757558373,0.938155134,,,0.010925066,0.017396055,0.529990985,0.827929097,0.7816114,,0.01421623,0.015845516,0.369624569,0.867151099,,,-0.013377946,0.016037769,0.404195017,0.775405465,0.7164963
AS3MT,1,rs3740393,0.007642595,0.020932165,-0.033424104,0.048709295,0.715090198,0.938155134,8.94E-01,,-0.005693482,0.021806485,0.794022148,0.935953998,,,-0.024120366,0.020160018,0.23152269,0.752448744,0.57880672,,0.016312699,0.020256237,0.420636569,0.775405465,
BHMT,2,rs3733890,0.02460177,0.01886884,-0.012417173,0.061620714,0.19253713,0.834327563,5.78E-01,,-0.02221893,0.019600115,0.256957243,0.703543658,0.5462182,,-0.003415115,0.017855895,0.848322061,0.951398401,0.90891649,,0.013719046,0.018055141,0.447349307,0.775405465,0.7164963
FOLR1,3,rs1540087,-0.004460737,0.032028391,-0.06729762,0.058376146,0.889256277,0.938155134,,,-0.028255275,0.033208004,0.394848599,0.789697197,,,0.014665365,0.030001942,0.624973479,0.951398401,,,0.002614105,0.030465015,0.931620018,0.9921763,
FOLR1,3,rs2071010,-0.00088381,0.023071578,-0.046147813,0.044380192,0.969448866,0.969448866,,,-0.004053191,0.023656029,0.863957537,0.935953998,,,-0.022355178,0.021822448,0.305640703,0.867151099,0.65494436,,0.018110017,0.021938252,0.409088035,0.775405465,0.7164963
FOLR1,3,rs7109250,-0.004074087,0.031489397,-0.065853012,0.057704838,0.897078419,0.938155134,9.02E-01,,-0.028634855,0.032595216,0.379673128,0.789697197,0.6327885,,0.022462455,0.029363136,0.44427851,0.867151099,,,-0.000825184,0.029866958,0.97795832,0.9921763,
FOLR2,4,rs2298444,-0.027128915,0.017162817,-0.06080047,0.00654264,0.114207778,0.742350559,5.42E-01,,-0.022663568,0.017632742,0.198683398,0.703543658,0.5462182,,-0.003939284,0.01602177,0.805782321,0.951398401,0.90891649,,0.019051117,0.016231357,0.240505989,0.775405465,0.601265
FOLR2,5,rs514933,0.006427218,0.017213218,-0.027344161,0.040198596,0.708925316,0.938155134,8.94E-01,,0.01887346,0.017619898,0.284104387,0.703543658,,,0.010765078,0.015970739,0.50027948,0.867151099,,,-0.016208737,0.016263097,0.318930789,0.775405465,
FOLR2,5,rs651646,0.005574099,0.01661227,-0.027017501,0.038165699,0.737274316,0.938155134,,,0.024419922,0.016890897,0.148248873,0.703543658,0.5462182,,0.02506053,0.015531607,0.106631987,0.752448744,0.57880672,,-0.027883286,0.015633242,0.074490399,0.484187596,0.372452
FOLR2,5,rs651933,0.005123007,0.016820961,-0.027878702,0.038124716,0.760753329,0.938155134,,,0.021987291,0.017191768,0.20091715,0.703543658,,,0.019595573,0.015543147,0.207409351,0.752448744,,,-0.024166179,0.015840743,0.127116711,0.661006896,
MTHFD1,6,rs11627387,0.01542536,0.018895192,-0.021645618,0.052496337,0.414452515,0.938155134,,,-0.007341827,0.019513733,0.706739231,0.935953998,0.8803888,,0.001903165,0.017790191,0.914806155,0.951398401,,,-0.00017686,0.018036421,0.9921763,0.9921763,
MTHFD1,6,rs2236224,0.006232744,0.017418085,-0.027940428,0.040405916,0.720531938,0.938155134,,,-0.003251758,0.018037289,0.856932964,0.935953998,,,0.011137143,0.01646718,0.498835182,0.867151099,0.83139197,,-0.004671221,0.016638465,0.778903449,0.920522258,0.7789034
MTHFD1,6,rs2236225,0.016291054,0.016654031,-0.016382556,0.048964663,0.328166311,0.938155134,6.67E-01,,-0.000633119,0.017252762,0.97072684,0.97072684,,,0.005385707,0.015752072,0.732422636,0.951398401,,,-0.003532007,0.015919343,0.824415931,0.931948443,
MTHFD1,7,rs1950902,-0.02402277,0.025673707,-0.074391634,0.026346093,0.349612794,0.938155134,6.67E-01,,0.031265129,0.02605983,0.230238712,0.703543658,0.5462182,,-0.010637226,0.02409495,0.658871938,0.951398401,0.90891649,,-0.015901375,0.024200574,0.511138463,0.803790074,0.7164963
MTHFR,8,rs1476413,-0.009901654,0.016625093,-0.042518281,0.022714973,0.551561982,0.938155134,,,-0.012061843,0.017283863,0.485260185,0.827929097,,,-0.014294717,0.015763186,0.364490444,0.867151099,,,0.016146654,0.015955728,0.311554314,0.775405465,
MTHFR,8,rs1801131,-0.034307741,0.017268766,-0.06818813,-0.000427352,0.0471839*,0.50646576,,,-0.033093919,0.017934993,0.065006265,0.563387629,0.3250313,,-0.021631607,0.016254292,0.183246839,0.752448744,,,0.036072363,0.016498151,0.028782784,0.374176198,
MTHFR,8,rs1801133,0.292282273,0.024041397,0.245115626,0.33944892,3.38E-32,8.79E-31,5.07E-31,,0.026742655,0.025677564,0.297653086,0.703543658,,,0.070038596,0.023142752,0.002475069,0.064351801,0.03712604,,-0.060160465,0.023606617,0.01082004,0.281321048,0.1623006
MTR,9,rs1805087,-0.014018602,0.018554848,-0.050421256,0.022384052,0.450080274,0.938155134,7.50E-01,,0.038879724,0.018873741,0.039399458,0.51219296,0.2954959,,0.012059279,0.017312775,0.486082094,0.867151099,0.83139197,,-0.034310814,0.017462335,0.049431962,0.42841034,0.3707397
MTRR,10,rs1801394,0.023601532,0.016163862,-0.008110337,0.055313401,0.144507066,0.751436744,5.42E-01,,0.000837834,0.016894932,0.960448419,0.97072684,0.9604484,,0.02024979,0.015442567,0.189757488,0.752448744,0.57880672,,-0.008779215,0.015583962,0.573197038,0.813782116,0.7164963
SHMT1,11,rs1979277,-0.020965223,0.022703222,-0.065507239,0.023576792,0.35595824,0.938155134,6.67E-01,,0.050239495,0.023214807,0.03045558,0.51219296,0.2954959,,-0.007478396,0.021479754,0.727719868,0.951398401,0.90891649,,-0.030751249,0.021566823,0.153909038,0.666939166,0.5771589
SLC19A1,12,rs1888530,-0.031261635,0.016504118,-0.063641209,0.001117939,0.058438357,0.50646576,4.38E-01,,-0.0096048,0.017048775,0.573181683,0.827929097,0.7816114,,-0.02048007,0.015583696,0.188779409,0.752448744,0.57880672,,0.018810179,0.015746474,0.232257221,0.775405465,0.601265
SLC46A1,13,rs1128162,-0.002104991,0.017103997,-0.03566214,0.031452159,0.902072244,0.938155134,9.02E-01,,0.004014821,0.017814842,0.82169626,0.935953998,0.8803888,,0.000960736,0.016280916,0.95294418,0.95294418,0.95294418,,-0.005762975,0.016452365,0.726126734,0.899014051,0.7789034
TCN2,14,rs1801198,-0.004117142,0.017612101,-0.038670227,0.030435944,0.815204173,0.938155134,9.02E-01,,0.004271474,0.018140665,0.813848584,0.935953998,0.8803888,,-0.020593084,0.016686822,0.217168388,0.752448744,0.57880672,,0.01066274,0.016796852,0.525555049,0.803790074,0.7164963
TYMS,15,rs1001761,-0.005668066,0.016679748,-0.03839221,0.027056079,0.734052624,0.938155134,,,0.011512176,0.017292161,0.50557387,0.827929097,,,-0.0019838,0.015780909,0.899962397,0.951398401,,,-0.007783387,0.015969722,0.625986243,0.813782116,
TYMS,15,rs2847149,-0.002307258,0.016591431,-0.034857922,0.030243405,0.889422957,0.938155134,,,0.009949589,0.017115115,0.561015759,0.827929097,,,0.00170899,0.01568507,0.913236999,0.951398401,,,-0.007966995,0.015850461,0.615220983,0.813782116,
TYMS,15,rs502396,0.007872656,0.016395714,-0.024294058,0.04003937,0.631195262,0.938155134,8.94E-01,,0.017893731,0.016957053,0.291316394,0.703543658,0.5462182,,0.005464334,0.015457657,0.723711084,0.951398401,0.90891649,,-0.01507594,0.01565216,0.33545424,0.775405465,0.7789034
,,,,,,,,,,,,,,,,,,,,,,,,,,,
,,,*Association for rs1801131 with Hcys was attenuated after adjustment for rs1801133.,,,,,,,,,,,,,,,,,,,,,,,,
,,,FDR1: false discovery rate adjustment for all 26 SNPs; FDR2: false discovery rate adjustment for top SNPs in 15 linkage disequilibrium blocks.,,,,,,,,,,,,,,,,,,,,,,,,