Molecular mechanism for inhibition of twinfilin by phosphoinositides

Supporting Information

• Supplementary information - Supporting molecular dynamics simulation results, supporting table, supporting figures, and supporting movie legends
• Movie S1 - A simulation of the C-terminal tail alone starting from random coil conformation.
• Movie S2 - A simulation of the C-terminal tail starting from the helical conformation.
• Movie S3 - A simulation of twinfilin with the tail in an α-helical conformation and phosphoinositide-rich membrane.
• Movie S4 - A simulation of twinfilin without its tail and phosphoinositide-rich membrane.
• Movie S5 - A simulation of twinfilin with the tail in a coil conformation and phosphoinositide-rich membrane.
• Movie S6 - A simulation of twinfilin with the tail in a β-sheet conformation and phosphoinositide-rich membrane.
• Movie S7 - A simulation of the twinfilin's C-terminal tail alone and phosphoinositide-rich membrane.