This PDF file includes:

• fig. S1. Confocal microphotographs of glycan expressions in IVD at post-injury day 29.
  
• fig. S2. Glycosignatures of IVD post-implantation of HA hydrogel at day 29.
  
• fig. S3. Number of extracted proteins in the disc.
  
• fig. S4. IPA revealed canonical “acute-phase signaling” in AF and NP tissues from the data set of differentially expressed proteins in our experimental groups.
  
• fig. S5. Inflammation network in the injured disc analyzed by IPA.
  
• fig. S6. Dysregulation of ECM proteins in the disc.

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