Unique Phenotypic Characteristics of Recently Transmitted HIV-1 Subtype C Envelope Glycoprotein gp120: Use of CXCR6 Coreceptor by Transmitted Founder Viruses

Supplemental material

• Supplemental file 1 -

  Fig. S1 (Maximum likelihood phylogenetic tree of Env V1–V3 region obtained from pediatric and adult samples.)

  Fig. S2 (Highlighter plot of amino acid diversity in variable region (V1–V3) of 65 infectious viral variants.)

  Fig. S3 (Phylogeny and highlighter analysis of the variable regions (V1–V3) of the env amplicon and per-infectious-particle infectivity of the corresponding viral variants.)

  Fig. S4 (Neutralization sensitivity of viruses to a panel of bNAbs, VRC01, PG09, PG16, and PGT121, targeting different epitopes on HIV-1 gp120 and a pool of mAbs, QUAD (equal ratio of 4 nAbs).)

  Fig. S5 (Neutralization potency of monoclonal antibodies against 65 infectious viruses.)

  Table S1 (Length of amino acid sequences and incorporation of PNGs in V1–V3 region of Env of recombinant viruses.)

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