TABLE 2.
IC50s of SB258585 calculated for Huh-7.5 cells infected with the indicated JFH1-based HCV genotype 1 to 6 recombinant viruses with strain-specific core-NS2a
| Virus (genotype) | IC50 (μM) |
|---|---|
| H77 (1a) | 15.03 |
| TN (1a) | 12.44 |
| DH6 (1a) | 6.971 |
| J4 (1b) | 8.468 |
| DH1 (1b) | 5.585 |
| DH5 (1b) | 11.65 |
| J6 (2a) | 11.15 |
| T9 (2a) | 17.79 |
| J8 (2b) | 12.54 |
| DH8 (2b) | 13.93 |
| DH10 (2b) | 7.108 |
| S83 (2c) | 7.919 |
| S52 (3a) | 7.436 |
| DBN (3a) | 17.06 |
| DH11 (3a) | 14.01 |
| ED43 (4a) | 7.591 |
| SA13 (5a) | 7.237 |
| HK6a (6a) | 5.234 |
| J6ΔHVR1 (2a) | 8.235 |
a
IC50, 50% inhibitory concentration.