This PDF file includes:

• fig. S1. Selection of active compound and polymer blends for HME.
  
• fig. S2. Optimization of PVA_S/PLA_S ratio for CBS-loaded filaments.
  
• fig. S3. Thermal properties of CBS-loaded and VA-loaded filaments.
  
• fig. S4. Characterizations of polymer mixtures containing CBS or VA.
  
• fig. S5. Surface and cross-section of unloaded filaments.
  
• fig. S6. Optimization of temperature for 3D printing.
  
• fig. S7. Evaluation of the VA concentration and the weight of the mouthguards.
  
• fig. S8. Release profiles of the personalized mouthguards in vitro.
  
• table S1. Physicochemical properties of CBS and VA.
  
• table S2. Feed compositions for the prepared blend filaments and the CBS loading efficiencies for the corresponding filaments.
  
• table S3. Solubility parameter calculations of individual components of the filaments based on the Hoftyzer and Van Krevelen method and the Hoy method.
  
• table S4. Mechanical properties of pure PLA_S filaments, pure PVA_S filaments, and the CBS-loaded blend filaments.
  
• table S5. Mechanical properties of pure PLA_PG, PVA_PG filaments, and the VA-loaded blend filaments.
  
• table S6. Optimization of the filament temperature and composition for the VA-free region in the mouthguard.
  
• table S7. AUC of VA concentrations in saliva after each cycle of wearing of the three different mouthguards.
  
• Methods
  
• References (49, 50)

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Other Supplementary Material for this manuscript includes the following:

• movie S1 (.mp4 format). Movie summarizing the different steps involved in the preparation of the 3D-printed compound-eluting mouthguards.