{"text_format":"2","workbook":"xlsx","n_sheets":3,"sheets":["pregnancy categories","gene targets","GTT rationale"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"pregnancy categories","index":0,"n_rows":134,"n_cols":6,"rows_kept":134,"cut":false,"hidden":false,"merged":[[1,0,1,5]]}
["Table S1a: Drug categories"]
["Pregnancy categories from the Australian Therapeutic Goods Agency and the US FDA are as shown. Australia subdivides the B category into B1, B2, and B3, as explained in the text.  'na' indicates the medication is not rated in that country. Medications recommended by textbooks (Tarascon and FM Obstetrics) are indicated by a Y. Blank indicates not mentioned."]
[]
[]
[]
["Drug Name","Australian category","FDA","Tarascon 2012","FM Obstetrics Petrie 2008","Mechanistic category"]
["acetaminophen","A","C","Y","Y","NSAID"]
["agomelatine","B1","na",null,null,"Melatonin receptor agonist"]
["alglucosidase alfa","B1","na",null,null,"Pompe disease"]
["alosetron","na","B",null,"Y","5-HT3 antagonist (IBS)"]
["amitriptyline","C","C",null,"Y","Tricyclic antidepressent"]
["anakinra","B1","B",null,null,"IL-1 receptor antagonist"]
["aprepitant","B1","B",null,null,"Substance P / NK1 receptor antagonist"]
["atropine","A","C",null,null,"Antimuscarinic"]
["beclomethasone","C","C","Y",null,"Corticosteroid"]
["benzhexol","B1","C",null,null,"Antimuscarinic"]
["betamethasone","A","C",null,null,"Corticosteroid"]
["bisoprolol","C","C",null,"Y","Beta blocker"]
["bromocriptine","A","B",null,null,"Dopamine D2 agonist"]
["brompheniramine","A","C",null,null,"Antihistamine"]
["bupropion","B2","C","Y",null,"Atypical antidepressent"]
["buspirone","B1","B","Y","Y","5-HT 1 agonist"]
["cabergoline","B1","B",null,null,"Dopamine D2 agonist"]
["caffeine","A","C",null,null,"Phosphodiesterase inhibitor, adenosine reuptake inhibitor"]
["calcium carbimide","A","na",null,null,"Aldehyde dehydrogenase inhibitor"]
["carglumic acid","B1","na",null,null,"Ammonia cycle activator"]
["carvedilol","C","C",null,"Y","Beta blocker"]
["cetirizine","B2","B",null,"Y","Antihistamine"]
["chloral hydrate","A","na",null,null,"GABA-A agonist"]
["chlormethiazole","A","na",null,null,"GABA-A agonist"]
["chloroquine","A","na",null,null,"Autophagy inhibitor"]
["chlorpheniramine","A","B","Y","Y","Antihistamine"]
["cimetidine","B1","B","Y","Y","H2 blocker"]
["clemastine","A","B",null,null,"Antihistamine"]
["clofibrate","B1","C",null,null,"Fibrate"]
["clonidine","B3","C",null,"Y","A2 agonist"]
["clopidogrel","B1","B",null,null,"P2Y12 antagoinist (ADP receptor)"]
["codeine","A","C","Y",null,"Opiate"]
["corticotrophin","A","na",null,null,"ACTH"]
["cortisone","A","na",null,null,"Corticosteroid"]
["cyproheptadine","A","B",null,null,"Antihistamine"]
["desipramine","C","C","Y","Y","Tricyclic antidepressent"]
["dexamethasone","A","C",null,null,"Corticosteroid"]
["dextromethorphan","A","C","Y","Y","Serotonin transporter, Norepinephrine tranporter, Mu opiate, Sigma"]
["digoxin","A","C",null,"Y","Cardiac glycoside"]
["dihydrocodeine","A","C",null,null,"Opiate"]
["dimethyl fumarate","B1","C",null,null,"Oxidative stress pathway activator"]
["diphenhydramine","A","B","Y","Y","Antihistamine"]
["diphenoxylate","C","C",null,"Y","Opiate"]
["dipyridamole","B1","B",null,null,"Phosphodiesterase inhibitor, adenosine reuptake inhibitor"]
["dolasetron","B1","B",null,null,"5-HT3 antagonist (n/v)"]
["doxepin","C","B","Y",null,"Tricyclic antidepressent"]
["doxylamine","A","B","Y","Y","Antihistamine"]
["duloxetine","B3","C",null,"Y","SNRI"]
["eletriptan","B1","C",null,"Y","Triptan (5-HT1B and -D agnoist)"]
["ephedrine","A","na",null,null,"Norepinephrine transporter inhibitor"]
["epoprostenol","B1","B",null,null,"Prostaglandin"]
["erythromycin","A","B","Y","Y","Motilin agonist"]
["evolocumab","B1","na",null,null,"Anti-PCSK9"]
["famotidine","B1","B","Y","Y","H2 blocker"]
["fexofenadine","B2","C",null,"Y","Antihistamine"]
["gabapentin","B1","C",null,null,"GABA synthesis and calcium channel blocker"]
["galantamine","B1","B",null,null,"Central nicotinic receptor agonist"]
["glyburide","C","B",null,"Y","Sulfonylurea"]
["granisetron","B1","B",null,null,"5-HT3 antagonist (n/v)"]
["hydralazine","C","C","Y","Y","direct vasodilator"]
["hydrocortisone","A","C",null,null,"Corticosteroid"]
["hydroxyzine","A","C",null,null,"Antihistamine"]
["imipramine","C","C",null,"Y","Tricyclic antidepressent"]
["insulin aspart","A","C","Y",null,"Insulin"]
["insulin detemir","A","B","Y",null,"Insulin"]
["insulin lispro","A","C","Y",null,"Insulin"]
["isoniazid","A","C",null,"Y","MAOI inhibitor, p450 inhibitor"]
["isoprenaline","A","C",null,null,"Beta agonist and TAAR1 agonist"]
["isosorbide dinitrate","B1","C",null,null,"Nitrate"]
["labetalol","C","C","Y","Y","Beta blocker"]
["lansoprazole","B3","B",null,"Y","Proton pump inhibitor"]
["lidocaine","A","B",null,null,"Antiarrhythmic class Ib"]
["loratadine","B1","B",null,"Y","Antihistamine"]
["lurasidone","B1","B",null,null,"Atypical antipsychotic"]
["maraviroc","B1","B",null,null,"HIV CCR5 inhibitor"]
["meclizine","Na","B","Y","Y","Antihistamine"]
["memantine","B2","B",null,null,"NMDA receptor antagonist"]
["meperidine","C","C","Y",null,"Opiate"]
["mepolizumab","B1","N",null,null,"Anti-IL5"]
["metformin","C","B",null,"Y","AMPK inhibition (indirect / incomplete)"]
["methadone","C","C","Y",null,"Opiate"]
["methyldopa","A","B","Y","Y","DOPA decarboxylase inhibitor and a2 agonist"]
["methylnaltrexone","B1","B",null,null,"Opiate"]
["methylprednisolone","A","C",null,null,"Corticosteroid"]
["metoclopramide","A","B","Y","Y","Dopamine D2 antagonist (nausea)"]
["mexiletine","B1","C",null,null,"Antiarrhythmic class Ib"]
["mirtazapine","B3","C",null,"Y","Atypical antidepressent"]
["montelukast","B1","B",null,"Y","Leukotriene receptor antagonist"]
["naloxone","B1","C",null,null,"Opiate"]
["nifedipine","C","C","Y",null,"Calcium channel blocker (dihydropyridine)"]
["nizatidine","B3","B","Y","Y","H2 blocker"]
["nortriptyline","C","C",null,"Y","Tricyclic antidepressent"]
["omalizumab","B1","B",null,null,"Anti-IgE"]
["omeprazole","B3","C",null,"Y","Proton pump inhibitor"]
["ondansetron","B1","B","Y","Y","5-HT3 antagonist (n/v)"]
["opium alkaloids","A","C",null,null,"Opiate"]
["oxybutynin","B1","B",null,null,"M1, M2, M3 antagonist"]
["oxycodone","C","B","Y",null,"Opiate"]
["palonosetron","B1","B",null,null,"5-HT3 antagonist (n/v)"]
["pantoprazole","B3","B",null,"Y","Proton pump inhibitor"]
["pentoxifylline","B1","C",null,null,"Phosphodiesterase inhibitor, adenosine reuptake inhibitor"]
["pheniramine","A","C",null,null,"Antihistamine"]
["pizotifen","B1","Na",null,null,"5-HT2A, 2C antagonist, dirty"]
["prasugrel","B1","B",null,null,"P2Y12 antagoinist (ADP receptor)"]
["prazosin","B2","C",null,"Y","A1 blocker"]
["prednisolone","A","C",null,null,"Corticosteroid"]
["prednisone","A","C",null,null,"Corticosteroid"]
["prochlorperazine","C","C",null,"Y","Dopamine D2 antagonist (nausea)"]
["procyclidine","A","C",null,null,"Anticholinergic"]
["promethazine","C","C",null,"Y","Dopamine D2 antagonist (nausea)"]
["propranolol","C","C",null,"Y","Beta blocker"]
["rabeprazole","B1","B",null,null,"Proton pump inhibitor"]
["ranitidine","B1","B","Y","Y","H2 blocker"]
["reboxetine","B1","Na",null,null,"Norepinephrine reuptake inhbitor"]
["rizatriptan","B1","C",null,"Y","Triptan (5-HT1B and -D agnoist)"]
["sapropterin","B1","C",null,null,"PKU treatment"]
["sildenafil","B1","B",null,null,"PDE5 inhibitor"]
["sumatriptan","B3","C",null,"Y","Triptan (5-HT1B and -D agnoist)"]
["tadalafil","B1","B",null,null,"PDE5 inhibitor"]
["theophylline","A","C","Y",null,"Phosphodiesterase inhibitor, adenosine reuptake inhibitor"]
["ticlopidine","B1","C",null,null,"P2Y12 antagoinist (ADP receptor)"]
["tirofiban","B1","B",null,null,"Platelet GP IIb/IIIa inhibitor"]
["tranexamic acid","B1","B",null,null,"Fibrinolysis inhibitor"]
["trazodone","NA","C",null,"Y","Atypical antidepressent"]
["triamcinolone","A","C",null,null,"Corticosteroid"]
["triprolidine","A","C",null,"Y","Antihistamine"]
["venlafaxine","B2","C",null,"Y","SNRI"]
["zafirlukast","B1","B",null,null,"Leukotriene receptor antagonist"]

{"sheet":"gene targets","index":1,"n_rows":451,"n_cols":5,"rows_kept":451,"cut":false,"hidden":false,"merged":[[1,0,1,4],[3,0,3,4]]}
["Table S1b - Drug-gene interactions"]
["Sources beginning DB are from DrugBank.ca: Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, Chang Z, Woolsey J. DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D668-72. 16381955 "]
["Sources beginning PMID are PubMed unique identifiers."]
["Sources cited as \"PDSP\" are from the psychoactive drug screening program: Besnard J, Ruda GF, Setola V, Abecassis K, Rodriguiz RM, Huang XP, Norval S, Sassano MF, Shin AI, Webster LA, Simeons FR, Stojanovski L, Prat A, Seidah NG, Constam DB, Bickerton GR, Read KD, Wetsel WC, Gilbert IH, Roth BL, Hopkins AL. Nature. 2012 Dec 13;492(7428):215-20. doi: 10.1038/nature11691."]
["Sources beginning C are from the NCI thesaurus."]
[]
[]
[]
["Drug","Source","Gene","Gene Name","Comment"]
["acetaminophen","DB00316","PTGS1","Prostaglandin G/H synthase 1"]
["acetaminophen","DB00316","PTGS2","Prostaglandin G/H synthase 2"]
["agomelatine","DB06594","MTNR1B","Melatonin receptor type 1B"]
["agomelatine","DB06594","MTNR1A","Melatonin receptor type 1A"]
["agomelatine","DB06594","HTR2C","5-hydroxytryptamine receptor 2C"]
["alglucosidase alfa","DB01272","M6PR","Cation-dependent mannose-6-phosphate receptor"]
["alglucosidase alfa","PMID: 20393176","GAA","Acid alpha-glucosidase"]
["alosetron","PDSP","HTR3B","Serotonin 5-HT receptor 3B"]
["alosetron","PDSP","HTR3C","Serotonin 5-HT receptor 3C"]
["alosetron","PDSP","HTR3D","Serotonin 5-HT receptor 3D"]
["alosetron","PDSP","HTR3E","Serotonin 5-HT receptor 3E"]
["alosetron","DB00969","HTR3A","5-hydroxytryptamine receptor 3A"]
["amitriptyline","PDSP","ADRA1A","Alpha adrenergic receptor 1A"]
["amitriptyline","PDSP","ADRA1B","Alpha adrenergic receptor 1B"]
["amitriptyline","PDSP","HTR2C","Serotonin 5-HT receptor 2C"]
["amitriptyline","DB00321","HTR2A","5-hydroxytryptamine receptor 2A"]
["amitriptyline","DB00321","SLC6A2","Sodium-dependent noradrenaline transporter"]
["amitriptyline","DB00321","SLC6A4","Sodium-dependent serotonin transporter"]
["amitriptyline","PDSP","HRH1","Histamine receptor H1"]
["anakinra","DB00026","IL1R1","Interleukin-1 receptor type 1"]
["anakinra","PMID: 11053099","IL1RAP","IL-1 Receptor adapter protein"]
["aprepitant","DB00673","TACR1","Substance-P receptor"]
["atropine","DB00572","CHRM3","Muscarinic acetylcholine receptor M3"]
["atropine","DB00572","CHRM1","Muscarinic acetylcholine receptor M1"]
["atropine","DB00572","CHRM5","Muscarinic acetylcholine receptor M5"]
["atropine","DB00572","CHRM4","Muscarinic acetylcholine receptor M4"]
["atropine","DB00572","CHRM2","Muscarinic acetylcholine receptor M2"]
["beclomethasone","DB00394","NR3C1","Glucocorticoid receptor","as beclomethazone dipropionate"]
["benzhexol","DB00376","CHRM1","Muscarinic acetylcholine receptor type 1","as Trihexyphenidyl"]
["betamethasone","DB00443","NR3C1","Glucocorticoid receptor"]
["bisoprolol","PDSP","ADRB2","Beta adrenergic receptor B2"]
["bisoprolol","DB00612","ADRB1","Beta-1 adrenergic receptor"]
["bromocriptine","DB01200","DRD3","D(3) dopamine receptor"]
["bromocriptine","DB01200","DRD2","D(2) dopamine receptor"]
["brompheniramine","DB00835","HRH1","Histamine H1 receptor"]
["bupropion","DB01156","SLC6A2","Sodium-dependent noradrenaline transporter"]
["bupropion","DB01156","SLC6A3","Sodium-dependent dopamine transporter"]
["buspirone","DB00490","HTR1A","5-hydroxytryptamine receptor 1A"]
["buspirone","DB00490","DRD2","D(2) dopamine receptor"]
["cabergoline","PDSP","DRD3","Dopamine D4 receptor"]
["cabergoline","PDSP","HTR1D","Serotonin 5-HT receptor 1D"]
["cabergoline","DB00248","DRD2","D(2) dopamine receptor"]
["cabergoline","PMID: 21518772","HTR2B","Serotonin 5-HT receptor 2B"]
["caffeine","DB00201","ADORA1","Adenosine receptor A1"]
["caffeine","DB00201","ADORA2A","Adenosine receptor A2a"]
["caffeine","PMID: 11692087","PDE1A","Phosphodiesterase 1A","specificity unclear"]
["caffeine","PMID: 11692087","PDE1B","Phosphodiesterase 1B","specificity unclear"]
["caffeine","PMID: 11692087","PDE1C","Phosphodiesterase 1C","specificity unclear"]
["caffeine","PMID: 11692087","PDE2A","Phosphodiesterase 2A","specificity unclear"]
["caffeine","PMID: 11692087","PDE3A","Phosphodiesterase 3A","specificity unclear"]
["caffeine","PMID: 11692087","PDE3B","Phosphodiesterase 3B","specificity unclear"]
["caffeine","PMID: 11692087","PDE4A","Phosphodiesterase 4A","specificity unclear"]
["caffeine","PMID: 11692087","PDE4B","Phosphodiesterase 4B","specificity unclear"]
["caffeine","PMID: 11692087","PDE4C","Phosphodiesterase 4C","specificity unclear"]
["caffeine","PMID: 11692087","PDE4D","Phosphodiesterase 4D","specificity unclear"]
["caffeine","PMID: 11692087","PDE5A","Phosphodiesterase 5A","specificity unclear"]
["caffeine","PMID: 11692087","PDE6A","Phosphodiesterase 6A","specificity unclear"]
["caffeine","PMID: 11692087","PDE6B","Phosphodiesterase 6B","specificity unclear"]
["caffeine","PMID: 11692087","PDE6C","Phosphodiesterase 6C","specificity unclear"]
["caffeine","PMID: 11692087","PDE6D","Phosphodiesterase 6D","specificity unclear"]
["caffeine","PMID: 11692087","PDE6G","Phosphodiesterase 6G","specificity unclear"]
["caffeine","PMID: 11692087","PDE6H","Phosphodiesterase 6H","specificity unclear"]
["caffeine","PMID: 11692087","PDE7A","Phosphodiesterase 7A","specificity unclear"]
["caffeine","PMID: 11692087","PDE7B","Phosphodiesterase 7B","specificity unclear"]
["caffeine","PMID: 11692087","PDE8A","Phosphodiesterase 8A","specificity unclear"]
["caffeine","PMID: 11692087","PDE8B","Phosphodiesterase 8B","specificity unclear"]
["caffeine","PMID: 11692087","PDE9A","Phosphodiesterase 9A","specificity unclear"]
["caffeine","PMID: 11692087","PDE10A","Phosphodiesterase 10A","specificity unclear"]
["caffeine","PMID: 11692087","PDE11A","Phosphodiesterase 11A","specificity unclear"]
["caffeine","PMID: 11692087","PDE12","Phosphodiesterase 12","specificity unclear"]
["calcium carbimide","PMID: 4041987","ALDH1A1","Acetaldehyde dehydrogenase"]
["calcium carbimide","PMID: 4041987","ALDH1B1","Acetaldehyde dehydrogenase"]
["calcium carbimide","PMID: 4041987","ALDH2","Acetaldehyde dehydrogenase"]
["carglumic acid","DB06775","CPS1","Carbamoyl-phosphate synthase [ammonia], mitochondrial"]
["carglumic acid","PMID: 21403788","NAGS","n-acetylglutamine synthase"]
["carvedilol","PDSP","ADRA1B","Alpha adrenergic receptor 1B"]
["carvedilol","PDSP","ADRA1D","Alpha adrenergic receptor 1D"]
["carvedilol","PDSP","ADRB2","Beta adrenergic receptor B2"]
["carvedilol","DB01136","ADRB1","Beta-1 adrenergic receptor"]
["carvedilol","DB01136","ADRA1A","Alpha-1A adrenergic receptor\r"]
["cetirizine","DB00341","HRH1","Histamine receptor H1"]
["chloral hydrate"," C28922 ","GABBR1","GABA receptor R1"]
["chloral hydrate"," C28922 ","GABBR2","GABA receptor R2"]
["chloral hydrate"," C28922 ","GABRA1","GABA receptor A1"]
["chloral hydrate"," C28922 ","GABRA2","GABA receptor A2"]
["chloral hydrate"," C28922 ","GABRA3","GABA receptor A3"]
["chloral hydrate"," C28922 ","GABRA4","GABA receptor A4"]
["chloral hydrate"," C28922 ","GABRA5","GABA receptor A5"]
["chloral hydrate"," C28922 ","GABRA6","GABA receptor A6"]
["chloral hydrate"," C28922 ","GABRB1","GABA receptor B1"]
["chloral hydrate"," C28922 ","GABRB2","GABA receptor B2"]
["chloral hydrate"," C28922 ","GABRB3","GABA receptor B3"]
["chloral hydrate"," C28922 ","GABRG1","GABA receptor G1"]
["chloral hydrate"," C28922 ","GABRG3","GABA receptor G3"]
["chloral hydrate"," C28922 ","GABRR1","GABA receptor R1"]
["chloral hydrate"," C28922 ","GABRR2","GABA receptor R2"]
["chlormethiazole","PMID: 14530209","GABBR1","GABA receptor R1"]
["chlormethiazole","PMID: 14530209","GABBR2","GABA receptor R2"]
["chlormethiazole","PMID: 14530209","GABRA1","GABA receptor A1"]
["chlormethiazole","PMID: 14530209","GABRA2","GABA receptor A2"]
["chlormethiazole","PMID: 14530209","GABRA3","GABA receptor A3"]
["chlormethiazole","PMID: 14530209","GABRA4","GABA receptor A4"]
["chlormethiazole","PMID: 14530209","GABRA5","GABA receptor A5"]
["chlormethiazole","PMID: 14530209","GABRA6","GABA receptor A6"]
["chlormethiazole","PMID: 14530209","GABRB1","GABA receptor B1"]
["chlormethiazole","PMID: 14530209","GABRB2","GABA receptor B2"]
["chlormethiazole","PMID: 14530209","GABRB3","GABA receptor B3"]
["chlormethiazole","PMID: 14530209","GABRG1","GABA receptor G1"]
["chlormethiazole","PMID: 14530209","GABRG3","GABA receptor G3"]
["chlormethiazole","PMID: 14530209","GABRR1","GABA receptor R1"]
["chlormethiazole","PMID: 14530209","GABRR2","GABA receptor R2"]
["chloroquine","PMID: 25343023","MAP1LC3A","LC3-I"]
["chloroquine","PMID: 25343023","MAP1LC3B","LC3-I"]
["chloroquine","PMID: 25343023","ATG5","ATG5"]
["chloroquine","PMID: 25343023","LAMP1","LAMP1"]
["chloroquine","PMID: 25343023","LAMP2","LAMP2"]
["chloroquine","PMID: 25343023","LAMP3","LAMP3"]
["chloroquine","PMID: 25343023","PSAP","CEREBROSIDE SULFATASE ACTIVATOR  Saposin B"]
["chlorpheniramine","DB01114  ","HRH1","Histamine receptor H1"]
["cimetidine","DB00501","HRH2","Histamine H2 receptor"]
["clemastine","DB00283","HRH1","Histamine H1 receptor"]
["clofibrate","DB00636","PPARA","Peroxisome proliferator-activated receptor alpha"]
["clonidine","DB00575","ADRA2A","Alpha-2A adrenergic receptor\r"]
["clonidine","DB00575","ADRA2C","Alpha-2C adrenergic receptor\r"]
["clonidine","DB00575","ADRA2B","Alpha-2B adrenergic receptor\r"]
["clopidogrel","DB00758","P2RY12","P2Y purinoceptor 12"]
["codeine","DB00318","OPRD1","Delta-type opioid receptor"]
["codeine","DB00318","OPRK1","Kappa-type opioid receptor"]
["codeine","DB00318","OPRM1","Mu-type opioid receptor"]
["corticotrophin","DB01285","MC2R","Melanocortin 2 receptor (ACTH receptor)"]
["cortisone","DB01380","NR3C1","Glucocorticoid receptor"]
["cyproheptadine","DB00434","HRH1","Histamine H1 receptor"]
["cyproheptadine","DB00434","HTR2A","5-hydroxytryptamine receptor 2A"]
["cyproheptadine","DB00434","HTR2C","5-hydroxytryptamine receptor 2C"]
["desipramine","DB01151","HTR2A","5-hydroxytryptamine receptor 2A"]
["desipramine","DB01151","SLC6A2","Sodium-dependent noradrenaline transporter"]
["desipramine","DB01151","SLC6A4","Sodium-dependent serotonin transporter"]
["dexamethasone","DB01234","NR3C1","Glucocorticoid receptor"]
["dextromethorphan","PDSP","OPRM1","Mu opiate receptor"]
["dextromethorphan","PDSP","SLC6A2","Norepinephrine transporter"]
["dextromethorphan","PDSP","SLC6A4","Serotonion transporter"]
["dextromethorphan","DB00514","SIGMAR1","Sigma non-opioid intracellular receptor 1\r"]
["dextromethorphan","DB00514","GRIN3A","Glutamate receptor ionotropic, NMDA 3A\r"]
["digoxin"," C28990","ATP1A2","Sodium-potassium ATPase"]
["digoxin"," C28990","ATP1A3","Sodium-potassium ATPase"]
["digoxin"," C28990","ATP1A4","Sodium-potassium ATPase"]
["digoxin"," C28990","ATP1B1","Sodium-potassium ATPase"]
["digoxin"," C28990","ATP1B2","Sodium-potassium ATPase"]
["digoxin"," C28990","ATP1B3","Sodium-potassium ATPase"]
["digoxin"," C28990","ATP1B4","Sodium-potassium ATPase"]
["digoxin","DB00390","ATP1A1","Sodium/potassium-transporting ATPase subunit alpha-1"]
["dihydrocodeine","PMID: 16777416","OPRM1","Mu opiate receptor"]
["dimethyl fumarate","PMID: 25584071 ","NFE2L2","Nuclear Factor, Erythroid 2-Like 2"]
["dimethyl fumarate","DB08908","KEAP1","Kelch-like ECH-associated protein 1"]
["diphenhydramine","DB01075","HRH1","Histamine H1 receptor"]
["diphenoxylate","DB01081","OPRM1","Mu-type opioid receptor"]
["dipyridamole","DB00975","PDE5A","cGMP-specific 3',5'-cyclic phosphodiesterase"]
["dipyridamole","DB00975","PDE10A","cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A"]
["dipyridamole","DB00975","PDE4A","cAMP-specific 3',5'-cyclic phosphodiesterase 4A"]
["dipyridamole","DB00975","ADA","Adenosine deaminase"]
["dipyridamole","PMID: 24021350","SLC29A1","Adenosine transporter A1"]
["dipyridamole","PMID: 16873718","SLC29A4","Adenosine transporter A4"]
["dipyridamole","PMID: 12838422","SLC29A3","Adenosine transporter A3"]
["dipyridamole","PMID: 9716350","PDE6A","Phosphodiesterase 6A"]
["dipyridamole","PMID: 9716350","PDE6B","Phosphodiesterase 6B"]
["dipyridamole","PMID: 9716350","PDE6C","Phosphodiesterase 6C"]
["dipyridamole","PMID: 9716350","PDE6D","Phosphodiesterase 6D"]
["dipyridamole","PMID: 9716350","PDE6G","Phosphodiesterase 6G"]
["dipyridamole","PMID: 9716350","PDE6H","Phosphodiesterase 6H"]
["dolasetron","PDSP","HTR3A","Serotonin 5-HT receptor 3A"]
["dolasetron","PDSP","HTR3B","Serotonin 5-HT receptor 3B"]
["dolasetron","PDSP","HTR3C","Serotonin 5-HT receptor 3C"]
["dolasetron","PDSP","HTR3D","Serotonin 5-HT receptor 3D"]
["dolasetron","PDSP","HTR3E","Serotonin 5-HT receptor 3E"]
["dolasetron","DB00757","HTR3A","5-hydroxytryptamine receptor 3A"]
["doxepin","DB01142","CHRM3","Muscarinic acetylcholine receptor M3"]
["doxepin","DB01142","CHRM1","Muscarinic acetylcholine receptor M1"]
["doxepin","DB01142","HRH2","Histamine H2 receptor"]
["doxepin","DB01142","CHRM5","Muscarinic acetylcholine receptor M5"]
["doxepin","DB01142","HTR1A","5-hydroxytryptamine receptor 1A"]
["doxepin","DB01142","HTR2B","5-hydroxytryptamine receptor 2B"]
["doxepin","DB01142","CHRM4","Muscarinic acetylcholine receptor M4"]
["doxepin","DB01142","HRH1","Histamine H1 receptor"]
["doxepin","DB01142","HTR2A","5-hydroxytryptamine receptor 2A"]
["doxepin","DB01142","SLC6A2","Sodium-dependent noradrenaline transporter"]
["doxepin","DB01142","HTR2C","5-hydroxytryptamine receptor 2C"]
["doxepin","DB01142","CHRM2","Muscarinic acetylcholine receptor M2"]
["doxepin","DB01142","SLC6A4","Sodium-dependent serotonin transporter"]
["doxylamine","DB00366","HRH1","Histamine H1 receptor"]
["duloxetine","DB00476","SLC6A2","Sodium-dependent noradrenaline transporter"]
["duloxetine","DB00476","SLC6A4","Sodium-dependent serotonin transporter"]
["eletriptan","DB00216","HTR1F","5-hydroxytryptamine receptor 1F"]
["eletriptan","DB00216","HTR1D","5-hydroxytryptamine receptor 1D"]
["eletriptan","DB00216","HTR1B","5-hydroxytryptamine receptor 1B"]
["eletriptan","PMID: 20404009, PDSP","HTR1A","Serotonin 5-HT receptor 1A"]
["ephedrine","PMID: 12954796","SLC6A2","Norepinephrine transporter"]
["epoprostenol","DB01240","P2RY12","P2Y purinoceptor 12"]
["epoprostenol","DB01240","PTGIS","Prostacyclin synthase"]
["epoprostenol","DB01240","PTGIR","Prostacyclin receptor"]
["erythromycin","PMID: 8470625","MLNR","Motilin receptor"]
["evolocumab","DB09303","PCSK9","PCSK9"]
["famotidine","DB00927","HRH2","Histamine H2 receptor"]
["fexofenadine","DB00950","HRH1","Histamine H1 receptor"]
["gabapentin","DB00996","CACNA2D1","Voltage-dependent calcium channel subunit alpha-2/delta-1"]
["gabapentin","DB00996","CACNA1B","Voltage-dependent N-type calcium channel subunit alpha-1B"]
["gabapentin","DB00996","CACNA2D2","Voltage-dependent calcium channel subunit alpha-2/delta-2"]
["gabapentin","PMID: 9686247","BCAT2","Branched Chain Amino-Acid Transaminase 2"]
["gabapentin","PMID: 9686247","BCAT1","Branched Chain Amino-Acid Transaminase 1"]
["gabapentin","PMID: 9686247","GAD1","Glutamate decarboxylase 1"]
["gabapentin","PMID: 9686247","GAD2","Glutamate decarboxylase 2"]
["galantamine","DB00674","ACHE","Acetylcholinesterase"]
["galantamine","PMID: 12481195","CHRNA4","Nicotinic acetylcholine receptor A4"]
["galantamine","PMID: 12481195","CHRNA7","Nicotinic acetylcholine receptor A7"]
["galantamine","PMID: 12481195","CHRNB2","Nicotinic acetylcholine receptor B2"]
["glyburide","DB01016","ABCC8","ATP-binding cassette sub-family C member 8"]
["glyburide","PMID: 21923736","ABCC9","Sulfonylurea receptor"]
["glyburide","PMID: 7502040","KCNJ11","Potassium inward rectifier Kir6.2"]
["granisetron","PDSP","HTR3B","Serotonin 5-HT receptor 3B"]
["granisetron","PDSP","HTR3C","Serotonin 5-HT receptor 3C"]
["granisetron","PDSP","HTR3D","Serotonin 5-HT receptor 3D"]
["granisetron","PDSP","HTR3E","Serotonin 5-HT receptor 3E"]
["granisetron","DB00889","HTR3A","5-hydroxytryptamine receptor 3A"]
["hydralazine","DB01275","AOC3","Membrane primary amine oxidase"]
["hydralazine","PMID: 26196301","PTGIR","Prostaglandin I2 receptor"]
["hydrocortisone","DB00741","ANXA1","Annexin A1"]
["hydrocortisone","DB00741","NR3C1","Glucocorticoid receptor"]
["hydroxyzine","DB00557","HRH1","Histamine H1 receptor"]
["imipramine","DB00458","SLC6A2","Sodium-dependent noradrenaline transporter"]
["imipramine","DB00458","SLC6A4","Sodium-dependent serotonin transporter"]
["insulin aspart","DB01306","INSR","Insulin receptor"]
["insulin detemir","DB01307","INSR","Insulin receptor"]
["insulin lispro","DB00046","INSR","Insulin receptor"]
["isoniazid","PMID: 11158730","CYP2C19","Cytochrome p450 2C19"]
["isoniazid","PMID: 11158730","CYP3A4","Cytochrome p450 3A4"]
["isoniazid","PMID: 11158730","CYP3A5","Cytochrome p450 3A5"]
["isoniazid","PMID: 11158730","CYP3A7","Cytochrome p450 3A7"]
["isoniazid","PMID: 11158730","CYP3A43","Cytochrome p450 3A43"]
["isoprenaline","DB01064","ADRB1","Beta-1 adrenergic receptor"]
["isoprenaline","DB01064","ADRB2","Beta-2 adrenergic receptor"]
["isoprenaline","DB01064","ADRB3","Beta-3 adrenergic receptor"]
["isosorbide dinitrate","DB00883","NPR1","Atrial natriuretic peptide receptor 1"]
["isosorbide dinitrate","PMID: 6115052","GUCY2C","Guanylate cyclase 2C"]
["isosorbide dinitrate","PMID: 6115052","GUCY2D","Guanylate cyclase 2D"]
["isosorbide dinitrate","PMID: 6115052","GUCY2F","Guanylate cyclase 2F"]
["labetalol","DB00598","ADRB1","Beta-1 adrenergic receptor"]
["labetalol","DB00598","ADRA1A","Alpha-1A adrenergic receptor\r"]
["labetalol","DB00598","ADRA1B","Alpha-1B adrenergic receptor\r"]
["labetalol","DB00598","ADRB2","Beta-2 adrenergic receptor"]
["labetalol","DB00598","ADRA1D","Alpha-1D adrenergic receptor\r"]
["lansoprazole","DB00448","ATP4A","Potassium-transporting ATPase alpha chain 1"]
["lidocaine","DB00281","SCN10A","Sodium channel protein type 10 subunit alpha"]
["lidocaine","DB00281","SCN5A","Sodium channel protein type 5 subunit alpha"]
["lidocaine","DB00281","SCN9A","Sodium channel protein type 9 subunit alpha"]
["loratadine","DB00455","HRH1","Histamine H1 receptor"]
["lurasidone","PDSP","ADRA2C","Alpha adrenergic receptor 2C"]
["lurasidone","DB08815","HTR2A","5-hydroxytryptamine receptor 2A"]
["lurasidone","DB08815","DRD2","D(2) dopamine receptor"]
["lurasidone","PMID: 20404009, PDSP","HTR1A","Serotonin 5-HT receptor 1A"]
["lurasidone","PMID: 20404009","HTR7","Serotonin 5-HT receptor 7"]
["maraviroc","DB04835","CCR5","C-C chemokine receptor type 5"]
["meclizine","DB00737","HRH1","Histamine H1 receptor"]
["memantine","DB01043","GRIN2B","Glutamate receptor ionotropic, NMDA 2B"]
["memantine","DB01043","GRIN3A","Glutamate receptor ionotropic, NMDA 3A\r"]
["memantine","DB01043","GRIN2A","Glutamate receptor ionotropic, NMDA 2A\r"]
["memantine","PMID: 10465680","GRIN1","NMDA receptor 1"]
["memantine","PMID: 10465680","GRIN2C","NMDA receptor 2C"]
["memantine","PMID: 10465680","GRIN2D","NMDA receptor 2D"]
["meperidine","DB00454","OPRK1","Kappa-type opioid receptor","as Pethidine"]
["mepolizumab","DB06612","IL5","Interleukin-5"]
["mepolizumab","DB06612","IL5RA","IL-5 receptor","IL-5 targets IL-5 receptor"]
["mepolizumab","DB06612","CSF2RB","IL-5 coreceptor","IL-5 targets IL-5 receptor"]
["metformin","PMC4627534","PRKAA1","Protein kinase A -A1"]
["metformin","PMC4627534","PRKAA2","Protein kinase A -A2"]
["metformin","PMC4627534","PRKAB2","Protein kinase A -B2"]
["metformin","PMC4627534","PRKAG1","Protein kinase A -G1"]
["metformin","PMC4627534","PRKAG2","Protein kinase A -G2"]
["metformin","PMC4627534","PRKAG3","Protein kinase A -G3"]
["metformin","DB00331","PRKAB1","5'-AMP-activated protein kinase subunit beta-1"]
["methadone","DB00333","CHRNA10","Neuronal acetylcholine receptor subunit alpha-10"]
["methadone","DB00333","OPRD1","Delta-type opioid receptor"]
["methadone","DB00333","GRIN3A","Glutamate receptor ionotropic, NMDA 3A\r"]
["methadone","DB00333","OPRM1","Mu-type opioid receptor"]
["methyldopa","PDSP","ADRA2B","Alpha adrenergic receptor 2B"]
["methyldopa","PDSP","ADRA2C","Alpha adrenergic receptor 2C"]
["methyldopa","PDSP","DDC","Dopa decarboxylase"]
["methyldopa","DB00968","ADRA2A","Alpha-2A adrenergic receptor\r"]
["methylnaltrexone","DB06800","OPRM1","Mu-type opioid receptor"]
["methylprednisolone","DB00959","NR3C1","Glucocorticoid receptor"]
["metoclopramide","PDSP","DRD3","Dopamine D3 receptor"]
["metoclopramide","PDSP","HTR3A","Serotonin 5-HT receptor 3A"]
["metoclopramide","PDSP","HTR3B","Serotonin 5-HT receptor 3B"]
["metoclopramide","PDSP","HTR3C","Serotonin 5-HT receptor 3C"]
["metoclopramide","PDSP","HTR3D","Serotonin 5-HT receptor 3D"]
["metoclopramide","PDSP","HTR3E","Serotonin 5-HT receptor 3E"]
["metoclopramide","PDSP","HTR4","Serotonin 5-HT receptor 4"]
["metoclopramide","DB01233","CHRM1","Muscarinic acetylcholine receptor M1"]
["metoclopramide","DB01233","DRD2","D(2) dopamine receptor"]
["mexiletine","DB00379","SCN5A","Sodium channel protein type 5 subunit alpha"]
["mirtazapine","DB00370","ADRA2A","Alpha-2A adrenergic receptor\r"]
["mirtazapine","DB00370","HTR3A","5-hydroxytryptamine receptor 3A"]
["mirtazapine","DB00370","HTR2A","5-hydroxytryptamine receptor 2A"]
["mirtazapine","PDSP","HTR2C","Serotonin 5-HT receptor 2C"]
["mirtazapine","PMID: 20404009, PDSP","HTR1A","Serotonin 5-HT receptor 1A"]
["montelukast","DB00471","CYSLTR1","Cysteinyl leukotriene receptor 1"]
["naloxone","DB01183","OPRD1","Delta-type opioid receptor"]
["naloxone","DB01183","OPRK1","Kappa-type opioid receptor"]
["naloxone","DB01183","OPRM1","Mu-type opioid receptor"]
["nifedipine","DB01115","CACNA1C","Voltage-dependent L-type calcium channel subunit alpha-1C"]
["nifedipine","DB01115","CACNA2D1","Voltage-dependent calcium channel subunit alpha-2/delta-1"]
["nifedipine","DB01115","CACNB2","Voltage-dependent L-type calcium channel subunit beta-2"]
["nifedipine","DB01115","CACNA1S","Voltage-dependent L-type calcium channel subunit alpha-1S"]
["nifedipine","DB01115","CACNA1D","Voltage-dependent L-type calcium channel subunit alpha-1D"]
["nizatidine","DB00585","HRH2","Histamine H2 receptor"]
["nortriptyline","PDSP","HTR2C","Serotonin 5-HT receptor 2C"]
["nortriptyline","DB00540","HTR2A","5-hydroxytryptamine receptor 2A"]
["nortriptyline","DB00540","SLC6A2","Sodium-dependent noradrenaline transporter"]
["nortriptyline","DB00540","SLC6A4","Sodium-dependent serotonin transporter"]
["nortryptiline","PDSP","HRH1","Histamine receptor H1"]
["omalizumab","DB00043","FCER1A","High affinity immunoglobulin epsilon receptor subunit alpha","need IgE targets, not omalizumab targets per se"]
["omalizumab","DB00043","MS4A2","High affinity immunoglobulin epsilon receptor subunit beta","need IgE targets, not omalizumab targets per se"]
["omalizumab","PMID: 27194387","FCER1G","IgE receptor 1G","need IgE targets, not omalizumab targets per se"]
["omalizumab","PMID: 27194387","FCER2","IgE receptor 2","need IgE targets, not omalizumab targets per se"]
["omeprazole","DB00338","ATP4A","Potassium-transporting ATPase alpha chain 1"]
["ondansetron","PDSP","HTR3B","Serotonin 5-HT receptor 3B"]
["ondansetron","PDSP","HTR3C","Serotonin 5-HT receptor 3C"]
["ondansetron","PDSP","HTR3D","Serotonin 5-HT receptor 3D"]
["ondansetron","PDSP","HTR3E","Serotonin 5-HT receptor 3E"]
["ondansetron","DB00904","HTR3A","5-hydroxytryptamine receptor 3A"]
["opium alkaloids","PMID: 15189164","OPRM1","Mu opiate receptor"]
["oxybutynin","DB01062","CHRM3","Muscarinic acetylcholine receptor M3"]
["oxybutynin","DB01062","CHRM1","Muscarinic acetylcholine receptor M1"]
["oxybutynin","DB01062","CHRM2","Muscarinic acetylcholine receptor M2"]
["oxycodone","DB00497","OPRD1","Delta-type opioid receptor"]
["oxycodone","DB00497","OPRK1","Kappa-type opioid receptor"]
["oxycodone","DB00497","OPRM1","Mu-type opioid receptor"]
["palonosetron","DB00377","HTR3A","5-hydroxytryptamine receptor 3A"]
["palonosetron","PDSP","HTR3A","Serotonin 5-HT receptor 3A"]
["palonosetron","PDSP","HTR3B","Serotonin 5-HT receptor 3B"]
["palonosetron","PDSP","HTR3C","Serotonin 5-HT receptor 3C"]
["palonosetron","PDSP","HTR3D","Serotonin 5-HT receptor 3D"]
["palonosetron","PDSP","HTR3E","Serotonin 5-HT receptor 3E"]
["pantoprazole","DB00213","ATP4A","Potassium-transporting ATPase alpha chain 1"]
["pentoxifylline","DB00806","ADORA1","Adenosine receptor A1"]
["pentoxifylline","DB00806","PDE5A","cGMP-specific 3',5'-cyclic phosphodiesterase"]
["pentoxifylline","DB00806","PDE4B","cAMP-specific 3',5'-cyclic phosphodiesterase 4B"]
["pentoxifylline","DB00806","ADORA2A","Adenosine receptor A2a"]
["pentoxifylline","DB00806","PDE4A","cAMP-specific 3',5'-cyclic phosphodiesterase 4A"]
["pentoxifylline","PMID: 8135854","PDE1A","Phosphodiesterase 1A"]
["pentoxifylline","PMID: 8135854","PDE1B","Phosphodiesterase 1B"]
["pentoxifylline","PMID: 8135854","PDE1C","Phosphodiesterase 1C"]
["pentoxifylline","PMID: 8135854","PDE3A","Phosphodiesterase 3A"]
["pentoxifylline","PMID: 8135854","PDE3B","Phosphodiesterase 3B"]
["pentoxifylline","PMID: 8135854","PDE4C","Phosphodiesterase 4C"]
["pentoxifylline","PMID: 8135854","PDE4D","Phosphodiesterase 4D"]
["pheniramine","DB01620","HRH1","Histamine H1 receptor"]
["pizotifen","PDSP","HTR2C","Serotonin 5-HT receptor 2C"]
["pizotifen","20404009, PDSP","HTR2A","Serotonin 5-HT receptor 2A"]
["prasugrel","DB06209","P2RY12","P2Y purinoceptor 12"]
["prazosin","DB00457","ADRA1A","Alpha-1A adrenergic receptor\r"]
["prazosin","DB00457","ADRA1B","Alpha-1B adrenergic receptor\r"]
["prazosin","DB00457","ADRA1D","Alpha-1D adrenergic receptor\r"]
["prednisolone","DB00860","NR3C1","Glucocorticoid receptor"]
["prednisone","DB00635","NR3C1","Glucocorticoid receptor"]
["prochlorperazine","PDSP","DRD3","Dopamine D3 receptor"]
["prochlorperazine","PDSP","DRD4","Dopamine D4 receptor"]
["prochlorperazine","PDSP","HRH1","Histamine receptor H1"]
["prochlorperazine","DB00433","DRD2","D(2) dopamine receptor"]
["prochlorperazine","PMID: 20404009, PDSP","HTR2A","Serotonin 5-HT receptor 2A"]
["procyclidine","DB00387","CHRM3","Muscarinic acetylcholine receptor M3"]
["procyclidine","DB00387","CHRM1","Muscarinic acetylcholine receptor M1"]
["procyclidine","DB00387","CHRM4","Muscarinic acetylcholine receptor M4"]
["procyclidine","DB00387","CHRM2","Muscarinic acetylcholine receptor M2"]
["promethazine","PMID: 20404009, PDSP","DRD2","Dopamine D2 receptor"]
["promethazine","DB01069","HRH1","Histamine H1 receptor"]
["promethazine","PMID: 20404009, PDSP","HTR2A","Serotonin 5-HT receptor 2A"]
["propranolol","PDSP","ADRB2","Beta adrenergic receptor B2"]
["propranolol","DB00571","ADRB1","Beta-1 adrenergic receptor"]
["rabeprazole","DB01129","ATP4A","Potassium-transporting ATPase alpha chain 1"]
["ranitidine","DB00863","HRH2","Histamine H2 receptor"]
["reboxetine","DB00234","SLC6A2","Sodium-dependent noradrenaline transporter"]
["rizatriptan","DB00953","HTR1F","5-hydroxytryptamine receptor 1F"]
["rizatriptan","DB00953","HTR1D","5-hydroxytryptamine receptor 1D"]
["rizatriptan","DB00953","HTR1B","5-hydroxytryptamine receptor 1B"]
["rizatriptan","20404009, PDSP","HTR1A","Serotonin 5-HT receptor 1A"]
["sapropterin","DB00360","TPH1","Tryptophan 5-hydroxylase 1"]
["sapropterin","DB00360","NOS3","Nitric oxide synthase, endothelial"]
["sapropterin","DB00360","TH","Tyrosine 3-monooxygenase"]
["sapropterin","DB00360","PAH","Phenylalanine-4-hydroxylase"]
["sapropterin","PMID: 19323589","NOS1","Nitric oxide synthase 1"]
["sapropterin","PMID: 19323589","NOS2","Nitric oxide synthase 2"]
["sapropterin","PMID: 19323589","TPH2","Tryptophan hydroxylase 2"]
["sildenafil","DB00203","PDE5A","cGMP-specific 3',5'-cyclic phosphodiesterase"]
["sumatriptan","DB00669","HTR1A","5-hydroxytryptamine receptor 1A"]
["sumatriptan","DB00669","HTR1F","5-hydroxytryptamine receptor 1F"]
["sumatriptan","DB00669","HTR1D","5-hydroxytryptamine receptor 1D"]
["sumatriptan","DB00669","HTR1B","5-hydroxytryptamine receptor 1B"]
["tadalafil","DB00820","PDE5A","cGMP-specific 3',5'-cyclic phosphodiesterase"]
["theophylline","DB00277","ADORA1","Adenosine receptor A1"]
["theophylline","DB00277","PDE5A","cGMP-specific 3',5'-cyclic phosphodiesterase"]
["theophylline","DB00277","ADORA2B","Adenosine receptor A2b"]
["theophylline","DB00277","PDE3A","cGMP-inhibited 3',5'-cyclic phosphodiesterase A"]
["theophylline","DB00277","PDE4B","cAMP-specific 3',5'-cyclic phosphodiesterase 4B"]
["theophylline","DB00277","ADORA2A","Adenosine receptor A2a"]
["theophylline","DB00277","PDE4A","cAMP-specific 3',5'-cyclic phosphodiesterase 4A"]
["theophylline","DB00277","HDAC2","HDAC2    Histone deacetylase 2\r"]
["theophylline","PMID: 9476844","PDE1A","Phosphodiesterase 1A","specificity unclear"]
["theophylline","PMID: 9476844","PDE1B","Phosphodiesterase 1B","specificity unclear"]
["theophylline","PMID: 9476844","PDE1C","Phosphodiesterase 1C","specificity unclear"]
["theophylline","PMID: 9476844","PDE2A","Phosphodiesterase 2A","specificity unclear"]
["theophylline","PMID: 9476844","PDE3B","Phosphodiesterase 3B","specificity unclear"]
["theophylline","PMID: 9476844","PDE4C","Phosphodiesterase 4C","specificity unclear"]
["theophylline","PMID: 9476844","PDE4D","Phosphodiesterase 4D","specificity unclear"]
["theophylline","PMID: 9476844","PDE6A","Phosphodiesterase 6A","specificity unclear"]
["theophylline","PMID: 9476844","PDE6B","Phosphodiesterase 6B","specificity unclear"]
["theophylline","PMID: 9476844","PDE6C","Phosphodiesterase 6C","specificity unclear"]
["theophylline","PMID: 9476844","PDE6D","Phosphodiesterase 6D","specificity unclear"]
["theophylline","PMID: 9476844","PDE6G","Phosphodiesterase 6G","specificity unclear"]
["theophylline","PMID: 9476844","PDE6H","Phosphodiesterase 6H","specificity unclear"]
["theophylline","PMID: 9476844","PDE7A","Phosphodiesterase 7A","specificity unclear"]
["theophylline","PMID: 9476844","PDE7B","Phosphodiesterase 7B","specificity unclear"]
["theophylline","PMID: 9476844","PDE8A","Phosphodiesterase 8A","specificity unclear"]
["theophylline","PMID: 9476844","PDE8B","Phosphodiesterase 8B","specificity unclear"]
["theophylline","PMID: 9476844","PDE9A","Phosphodiesterase 9A","specificity unclear"]
["theophylline","PMID: 9476844","PDE10A","Phosphodiesterase 10A","specificity unclear"]
["theophylline","PMID: 9476844","PDE11A","Phosphodiesterase 11A","specificity unclear"]
["theophylline","PMID: 9476844","PDE12","Phosphodiesterase 12","specificity unclear"]
["ticlopidine","DB00208","P2RY12","P2Y purinoceptor 12"]
["tirofiban","DB00775","ITGA2B","Integrin alpha-IIb"]
["tirofiban","DB00775","ITGB3","Integrin beta-3"]
["tranexamic acid","DB00302","PLG","Plasminogen"]
["tranexamic acid","PMID: 26258658","PLAT","Tissue plasminogen activator (tPA)"]
["trazodone","PDSP","ADRA1A","Alpha adrenergic receptor 1A"]
["trazodone","PDSP","HTR1D","Serotonin 5-HT receptor 1D"]
["trazodone","DB00656","HTR1A","5-hydroxytryptamine receptor 1A"]
["trazodone","DB00656","HTR2A","5-hydroxytryptamine receptor 2A"]
["trazodone","DB00656","HTR2C","5-hydroxytryptamine receptor 2C"]
["trazodone","DB00656","SLC6A4","Sodium-dependent serotonin transporter"]
["triamcinolone","DB00620","NR3C1","Glucocorticoid receptor"]
["triprolidine","DB00427","HRH1","Histamine H1 receptor"]
["venlafaxine","DB00285","SLC6A2","Sodium-dependent noradrenaline transporter"]
["venlafaxine","DB00285","SLC6A4","Sodium-dependent serotonin transporter"]
["zafirlukast","DB00549","CYSLTR1","Cysteinyl leukotriene receptor 1"]

{"sheet":"GTT rationale","index":2,"n_rows":68,"n_cols":4,"rows_kept":68,"cut":false,"hidden":false,"merged":[]}
["Table S1c: GTT rationale"]
["Categories are as given in table S1a."]
[]
["Mechanistic category","Example drug","Tested","Reason for not testing"]
["5-HT 1 agonist","buspirone","Yes"]
["H2 blocker","cimetidine","Yes"]
["Sulfonylurea","glyburide","Yes"]
["Insulin","insulin aspart","Yes"]
["Proton pump inhibitor","lansoprazole","Yes"]
["AMPK inhibition (indirect / incomplete)","metformin","Yes"]
["Tricyclic antidepressent","amitriptyline","Yes"]
["Corticosteroid","beclomethasone","Yes"]
["Beta blocker","bisoprolol","Yes"]
["Atypical antidepressent","bupropion","Yes"]
["A2 agonist","clonidine","Yes"]
["5-HT3 antagonist (n/v)","dolasetron","Yes"]
["SNRI","duloxetine","Yes"]
["Triptan (5-HT1B and -D agnoist)","eletriptan","Yes"]
["DOPA decarboxylase inhibitor and a2 agonist","methyldopa","Yes"]
["Dopamine D2 antagonist (nausea)","metoclopramide","Yes"]
["Leukotriene receptor antagonist","montelukast","Yes"]
["Calcium channel blocker (dihydropyridine)","nifedipine","Yes"]
["A1 blocker","prazosin","Yes"]
["Norepinephrine reuptake inhbitor","reboxetine","Yes"]
["NSAID","acetaminophen","No","OTC"]
["Melatonin receptor agonist","agomelatine","No","Not FDA approved"]
["Pompe disease","alglucosidase alfa","No","Not enough patients"]
["5-HT3 antagonist (IBS)","alosetron","No","Not enough patients"]
["IL-1 receptor antagonist","anakinra","No","Not enough patients"]
["Substance P / NK1 receptor antagonist","aprepitant","No","Not enough patients"]
["Antimuscarinic","atropine","No","OTC"]
["Dopamine D2 agonist","bromocriptine","No","Not enough patients"]
["Antihistamine","brompheniramine","No","OTC"]
["Phosphodiesterase inhibitor, adenosine reuptake inhibitor","caffeine","No","OTC"]
["Aldehyde dehydrogenase inhibitor","calcium carbimide","No","Not FDA approved"]
["Ammonia cycle activator","carglumic acid","No","Not enough patients"]
["GABA-A agonist","chloral hydrate","No","Not enough patients"]
["Autophagy inhibitor","chloroquine","No","Not enough patients"]
["Fibrate","clofibrate","No","Not enough patients"]
["P2Y12 antagoinist (ADP receptor)","clopidogrel","No","Not enough patients"]
["Opiate","codeine","No","Marks comorbidities"]
["ACTH","corticotrophin","No","Not enough patients"]
["Serotonin transporter, Norepinephrine tranporter, Mu opiate, Sigma","dextromethorphan","No","OTC"]
["Cardiac glycoside","digoxin","No","Not enough patients"]
["Oxidative stress pathway activator","dimethyl fumarate","No","Not enough patients"]
["Norepinephrine transporter inhibitor","ephedrine","No","OTC"]
["Prostaglandin","epoprostenol","No","Not enough patients"]
["Motilin agonist","erythromycin","No","Not enough patients"]
["Anti-PCSK9","evolocumab","No","Not enough patients"]
["GABA synthesis and calcium channel blocker","gabapentin","No","Used to treat diabetic neuropathy"]
["Central nicotinic receptor agonist","galantamine","No","Not enough patients"]
["direct vasodilator","hydralazine","No","Not enough patients"]
["MAOI inhibitor, p450 inhibitor","isoniazid","No","Not enough patients"]
["Beta agonist and TAAR1 agonist","isoprenaline","No","Not enough patients"]
["Nitrate","isosorbide dinitrate","No","Not enough patients"]
["Antiarrhythmic class Ib","lidocaine","No","Not enough patients"]
["Atypical antipsychotic","lurasidone","No","Not enough patients"]
["HIV CCR5 inhibitor","maraviroc","No","Not enough patients"]
["NMDA receptor antagonist","memantine","No","Not enough patients"]
["Anti-IL5","mepolizumab","No","Not enough patients"]
["Anti-IgE","omalizumab","No","Not enough patients"]
["M1, M2, M3 antagonist","oxybutynin","No","Not enough patients"]
["5-HT2A, 2C antagonist, dirty","pizotifen","No","Not enough patients"]
["Anticholinergic","procyclidine","No","Not enough patients"]
["PKU treatment","sapropterin","No","Not enough patients"]
["PDE5 inhibitor","sildenafil","No","Not enough patients"]
["Platelet GP IIb/IIIa inhibitor","tirofiban","No","Not enough patients"]
["Fibrinolysis inhibitor","tranexamic acid","No","Not enough patients"]