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{"sheet":"Sheet1","index":0,"n_rows":68,"n_cols":13,"rows_kept":68,"cut":false,"hidden":false,"merged":[[0,4,1,4],[0,0,1,0],[0,5,1,12]]}
["Product Name","Max Yield (H/ATP = 4)","Max Yield (H/ATP = 3)","Max Yield(H/ATP = 5)","Percent Decrease in Yield from H/ATP=3 to H/ATP=5","Reactions added to iSyp708 to enable synthesis of compound (Red numbers indicate stoichiometric coefficients)"]
[null,"(mmol product/μmol photons)","(mmol product/μmol photons)","(mmol product/μmol photons)"]
[]
["Ethanol",4.1666999999999999E-5,4.1666999999999999E-5,4.1666999999999999E-5,{"$f":"(C4-D4)/C4","v":0},"Pyruvate + H --> Acetaldehyde + CO2","Acetaldehyde + NADPH + H --> Ethanol + NADP"]
[]
["Glycerol",3.5714000000000004E-5,3.5714000000000004E-5,3.4783000000000002E-5,{"$f":"(C6-D6)/C6","v":2.6068208545668412E-2},"sn-Glycerol-3-phosphate + H2O --> Glycerol + Phosphate"]
[]
["Sucrose",1.0309000000000001E-5,1.0416999999999999E-5,9.4120000000000007E-6,{"$f":"(C8-D8)/C8","v":9.6476912738792178E-2},"(Pathway already in model)"]
[]
["2,3-Butanediol",2.2727000000000001E-5,2.2727000000000001E-5,2.2221999999999998E-5,{"$f":"(C10-D10)/C10","v":2.222026664319984E-2},"(S)-2-Acetolactate + H -->  (R)-Acetoin + CO2","(R)-Acetoin + NADPH + H --> 2,3-Butanediol + NADP"]
[]
["L-Lactate",4.1666999999999999E-5,4.1666999999999999E-5,4.1666999999999999E-5,{"$f":"(C12-D12)/C12","v":0},"Pyruvate + NADH + H --> L-Lactate + NAD"]
[]
["D-Mannitol",1.9231000000000003E-5,1.9231000000000003E-5,1.8182E-5,{"$f":"(C14-D14)/C14","v":5.4547345431854966E-2},"D-Fructose-6-phosphate + NADH + H --> D-Mannitol-1-phosphate + NAD","D-Mannitol-1-phosphate + H2O --> D-Mannitol + Phosphate"]
[]
["Isobutyraldehyde",2.2727000000000001E-5,2.2727000000000001E-5,2.2221999999999998E-5,{"$f":"(C16-D16)/C16","v":2.222026664319984E-2},"3-Methyl-2-oxobutanoate + H --> Isobutyraldehyde + CO2"]
[]
["Isobutanol",2.0833000000000002E-5,2.0833000000000002E-5,2.0833000000000002E-5,{"$f":"(C18-D18)/C18","v":0},"3-Methyl-2-oxobutanoate + H --> Isobutyraldehyde + CO2","Isobutyraldehyde + NADPH + H --> Isobutanol + NADP"]
[]
["2-Methyl-1-Butanol",1.6667000000000002E-5,1.6667000000000002E-5,1.6667000000000002E-5,{"$f":"(C20-D20)/C20","v":0},"3-Methyl-2-oxopentanoate + H --> 2-Methylbutyraldehyde + CO2","2-Methylbutyraldehyde + NADPH + H --> 2-Methyl-1-butanol + NADP"]
[]
["3-Hydroxybutyrate",2.7210999999999997E-5,2.7778000000000001E-5,2.4845E-5,{"$f":"(C22-D22)/C22","v":0.1055871553027576},"2 Acetyl-CoA --> Acetoacetyl-CoA + CoA","Acetoacetyl-CoA + NADPH + H --> 3-Hydroxybutanoyl-CoA + NADP","3-Hydroxybutanoyl-CoA + H2O --> 3-Hydroxybutanoate + CoA + H"]
[]
["Acetone",2.9411999999999999E-5,3.1250000000000001E-5,2.6667000000000001E-5,{"$f":"(C24-D24)/C24","v":0.14665600000000001},"2 Acetyl-CoA --> Acetoacetyl-CoA + CoA","Acetoacetyl-CoA + H2O --> Acetoacetate + CoA + H","Acetoacetate + H --> Acetone + CO2"]
[]
["Isopropanol",2.7397000000000002E-5,2.7778000000000001E-5,2.5000000000000001E-5,{"$f":"(C26-D26)/C26","v":0.10000719994240044},"2 Acetyl-CoA --> Acetoacetyl-CoA + CoA","Acetoacetyl-CoA + H2O --> Acetoacetate + CoA + H","Acetoacetate + H --> Acetone + CO2","Acetone + NADPH + H --> Isopropanol + NADP"]
[]
["1-Butanol",2.0833000000000002E-5,2.0833000000000002E-5,2.0513000000000002E-5,{"$f":"(C28-D28)/C28","v":1.5360245763932237E-2},"Malonyl-CoA + Acetyl-CoA + H --> Acetoacetyl-CoA + CO2 + CoA","Acetoacetyl-CoA + NADPH + H --> 3-Hydroxybutanoyl-CoA + NADP","3-Hydroxybutanoyl-CoA --> Crotonyl-CoA + H2O","Crotonyl-CoA + NADH + H --> Butyryl-CoA + NAD","Butyryl-CoA + NADH + H --> 1-Butyraldehyde + CoA + NAD","1-Butyraldehyde + NADPH + H --> 1-Butanol + NADP"]
[]
["1,2-Propanediol",3.1250000000000001E-5,3.1250000000000001E-5,3.1250000000000001E-5,{"$f":"(C30-D30)/C30","v":0},"Dihydroxyacetonephosphate --> Methylglyoxyl + Phosphate","Methylglyoxyl + NADPH + H --> Acetol + NADP","Acetol + NADPH + H --> 1,2-Propanediol + NADP"]
[]
["L-Lysine (Growth on nitrate)",1.1364E-5,1.1364000000000002E-5,1.1364000000000002E-5,{"$f":"(C32-D32)/C32","v":0},"(Complete pathway already in model.)"]
[]
["L-Lysine (Growth on ammonium)",1.7857000000000002E-5,1.7857000000000002E-5,1.7857000000000002E-5,{"$f":"(C34-D34)/C34","v":0},"(Complete pathway already in model.)"]
[]
[]
["Terpenes via MEP Pathway"]
["Isoprene",1.7857000000000002E-5,1.7857000000000002E-5,1.7021000000000002E-5,{"$f":"(C38-D38)/C38","v":4.6816374530996248E-2},"Dimethylallyl diphosphate --> Isoprene + Diphosphate"]
[]
["Limonene",8.9290000000000004E-6,8.9289999999999987E-6,8.5109999999999986E-6,{"$f":"(C40-D40)/C40","v":4.6813752939858899E-2},"Geranyl diphosphate --> Limonene + Disphosphate"]
[]
["Bisabolene",5.9519999999999999E-6,5.9519999999999999E-6,5.6740000000000002E-6,{"$f":"(C42-D42)/C42","v":4.670698924731178E-2},"Farnesyl diphosphate --> Bisabolene + Diphosphate"]
[]
["Squalene",2.9409999999999999E-6,2.9409999999999999E-6,2.8169999999999999E-6,{"$f":"(C44-D44)/C44","v":4.2162529751785111E-2},"2 Farnesyl diphsophate --> Presqualene diphosphate + Diphosphate","Presqualene diphosphate + NADPH + H --> Sqalene + Diphosphate + NADP"]
[]
[]
["Terpenes via MVA Pathway"]
["Isoprene",1.6948999999999996E-5,1.7857000000000002E-5,1.5384999999999999E-5,{"$f":"(C48-D48)/C48","v":0.13843310746485984},"2 Acetyl-CoA --> Acetoacetyl-CoA + CoA","Acetoacetyl-CoA + Acetyl-CoA + H2O --> HMG-CoA + CoA + H","HMG-CoA + 2 NADPH + 2 H --> Mevalonate + CoA + 2 NADP","Mevalonate + ATP --> Mevalonate-5-phosphate + ADP + H","Mevalonate-5-phosphate + ATP --> Mevalonate-5-diphosphate + ADP","Mevalonate-5-diphosphate + ATP --> Isopentenyl diphosphate + CO2 + ADP + Phosphate","Dimethylallyl diphosphate --> Isoprene + Diphosphate"]
[]
["Limonene",8.4749999999999993E-6,8.9289999999999987E-6,7.6920000000000002E-6,{"$f":"(C50-D50)/C50","v":0.13853735020718991},"2 Acetyl-CoA --> Acetoacetyl-CoA + CoA","Acetoacetyl-CoA + Acetyl-CoA + H2O --> HMG-CoA + CoA + H","HMG-CoA + 2 NADPH + 2 H --> Mevalonate + CoA + 2 NADP","Mevalonate + ATP --> Mevalonate-5-phosphate + ADP + H","Mevalonate-5-phosphate + ATP --> Mevalonate-5-diphosphate + ADP","Mevalonate-5-diphosphate + ATP --> Isopentenyl diphosphate + CO2 + ADP + Phosphate","Geranyl diphosphate --> Limonene + Disphosphate"]
[]
["Bisabolene",5.6499999999999993E-6,5.9519999999999999E-6,5.1279999999999999E-6,{"$f":"(C52-D52)/C52","v":0.13844086021505378},"2 Acetyl-CoA --> Acetoacetyl-CoA + CoA","Acetoacetyl-CoA + Acetyl-CoA + H2O --> HMG-CoA + CoA + H","HMG-CoA + 2 NADPH + 2 H --> Mevalonate + CoA + 2 NADP","Mevalonate + ATP --> Mevalonate-5-phosphate + ADP + H","Mevalonate-5-phosphate + ATP --> Mevalonate-5-diphosphate + ADP","Mevalonate-5-diphosphate + ATP --> Isopentenyl diphosphate + CO2 + ADP + Phosphate","Farnesyl diphosphate --> Bisabolene + Diphosphate"]
[]
["Squalene",2.8050000000000002E-6,2.9409999999999999E-6,2.548E-6,{"$f":"(C54-D54)/C54","v":0.13362801768106083},"2 Acetyl-CoA --> Acetoacetyl-CoA + CoA","Acetoacetyl-CoA + Acetyl-CoA + H2O --> HMG-CoA + CoA + H","HMG-CoA + 2 NADPH + 2 H --> Mevalonate + CoA + 2 NADP","Mevalonate + ATP --> Mevalonate-5-phosphate + ADP + H","Mevalonate-5-phosphate + ATP --> Mevalonate-5-diphosphate + ADP","Mevalonate-5-diphosphate + ATP --> Isopentenyl diphosphate + CO2 + ADP + Phosphate","2 Farnesyl diphsophate --> Presqualene diphosphate + Diphosphate","Presqualene diphosphate + NADPH + H --> Sqalene + Diphosphate + NADP"]
[]
[]
["Fatty Acids and Alcohols"]
["Octanoic Acid",1.1364E-5,1.1364000000000002E-5,1.0638E-5,{"$f":"(C58-D58)/C58","v":6.3885955649419318E-2},"Octanoyl-ACP + H2O --> Octanoic Acid + ACP + H"]
[]
["Octanol",1.0417E-5,1.0416999999999999E-5,9.8770000000000005E-6,{"$f":"(C60-D60)/C60","v":5.1838341173082295E-2},"Octanoyl-ACP + H2O --> Octanoic Acid + ACP + H","Octanoic Acid + ATP + CoA --> Octanoyl-CoA + AMP + Diphosphate","Octanoyl-CoA + 2 NADPH + 2 H --> Octanol + CoA + 2 NADP"]
[]
["Dodecanoic Acid",7.3529999999999997E-6,7.3530000000000006E-6,6.9439999999999999E-6,{"$f":"(C62-D62)/C62","v":5.5623555011559994E-2},"Dodecanoyl-ACP + H2O --> Dodecanoic Acid + ACP + H"]
[]
["Dodecanol",6.9439999999999999E-6,6.9439999999999999E-6,6.6119999999999995E-6,{"$f":"(C64-D64)/C64","v":4.7811059907834158E-2},"Dodecanoyl-ACP + H2O --> Dodecanoic Acid + ACP + H","Dodecanoic Acid + ATP + CoA --> Dodecanoyl-CoA + AMP + Diphosphate","Dodecanoyl-CoA + 2 NADPH + 2 H --> Dodecanol + CoA + 2 NADP"]
[]
["Hexadecanoic Acid",5.4349999999999996E-6,5.4349999999999996E-6,5.1549999999999998E-6,{"$f":"(C66-D66)/C66","v":5.1517939282428683E-2},"Palmitoyl-ACP + H2O --> Hexadecanoic Acid + ACP + H"]
[]
["Hexadecanol",5.2079999999999999E-6,5.2079999999999999E-6,4.9690000000000002E-6,{"$f":"(C68-D68)/C68","v":4.5890937019969227E-2},"Palmitoyl-ACP + H2O --> Hexadecanoic Acid + ACP + H","Hexadecanoic Acid + ATP + CoA --> Hexadecanoyl-CoA + AMP + Diphosphate","Hexadecanoyl-CoA + 2 NADPH + 2 H --> Hexadecanol + CoA + 2 NADP"]