Pathway_id	Pathway_name	Pathway_class	Annotated	Significant	SymbolList	Expected	classic_fisher	FDR
hsa03050	Proteasome	Folding, sorting and degradation	44	22	PSMD11,PSMC4,PSMD2,PSMD12,PSMA5,PSMD6,PSMB4,PSMC5,PSMA6,PSMA3,PSMA1,PSMC2,PSMC6,PSMC1,PSME4,PSMA2,PSMA4,POMP,SHFM1,PSMD1,PSME3,PSMB9	9.0046511627907	1.152656e-05	0.002502951
hsa03040	Spliceosome	Transcription	126	46	U2SURP,CRNKL1,TRA2B,BUD31,HSPA8,DHX15,MAGOHB,PLRG1,HNRNPK,BCAS2,SF3B2,RBMXL1,SRSF7,TCERG1,TRA2A,SNRPB2,DDX39B,RBM25,HNRNPU,USP39,SF3B3,CTNNBL1,CCDC12,THOC2,SNRPF,SNRPE,DDX42,THOC1,AQR,U2AF1,PRPF38B,HNRNPC,PRPF40A,LSM6,LSM5,HNRNPM,NCBP2,SF3B1,PRPF18,ACIN1,RBMX,DDX23,HNRNPA3,PPIE,SNRNP40,SRSF5	25.7860465116279	1.925347e-05	0.002502951
hsa05016	Huntington*s disease	Neurodegenerative diseases	181	59	POLR2G,COX7A2L,DNAI1,BBC3,MT-ATP6,CLTA,DCTN1,ATP5H,SDHD,TBPL2,NDUFB3,COX6A1,DCTN4,PLCB4,ATP5G3,NDUFA7,MT-CO1,POLR2J3,DNAH3,HDAC1,SLC25A31,POLR2E,HAP1,DNAI2,UQCRH,UQCRC2,COX5A,PLCB2,NDUFS8,ATP5B,POLR2I,CASP8,NDUFB4,DNALI1,UQCRB,ITPR1,NDUFB5,MT-CO3,VDAC3,CLTC,DNAH2,CREB5,NDUFB10,PLCB1,POLR2K,SP1,TBPL1,GRM5,HDAC2,POLR2H,COX6B2,SDHC,MT-CO2,NDUFA3,NDUFA9,DCTN2,ATP5E,BAX,NDUFB9	37.0418604651163	6.998954e-05	0.006065760
hsa05169	Epstein-Barr virus infection	Infectious diseases: Viral	197	62	CD44,POLR2G,IRAK1,PIK3R5,NCOR2,RBPJ,YWHAQ,USP7,ENTPD8,BCL2,PIK3CB,PSMD11,HSPA8,YWHAZ,PSMC4,TAB2,PSMD2,PSMD12,CSNK2A2,MAP2K4,PIK3CD,GSK3B,TBPL2,EIF2AK2,MDM2,TYK2,HLA-DPB1,PSMD6,ATF2,MAPK8,PIK3R2,MAP2K7,GTF2B,POLR2J3,PSMC5,HDAC1,POLR3F,POLR2E,MAP2K3,CSNK2A1,ITGAL,TRADD,CCNA1,TBK1,PSMC2,POLR2I,PSMC6,PIK3R3,CHUK,POLR3C,PSMC1,POLR2K,PIK3CA,TBPL1,XPO1,HDAC2,POLR1D,SHFM1,POLR2H,PSMD1,FCER2,AKT1	40.3162790697674	1.446815e-04	0.009404295
hsa03013	RNA transport	Translation	153	49	NUP155,SUMO1,EIF4G3,EIF1,NUP37,ELAC2,RGPD5,MAGOHB,EIF3D,THOC7,XPOT,NUP35,AAAS,EIF4E,EIF5B,PRMT5,NUPL2,EIF3J,NUP107,RNPS1,NUP205,DDX39B,DDX20,RAE1,EIF3B,THOC2,CYFIP1,EIF2S3,THOC1,STRAP,EIF3F,NUP50,SEH1L,FXR1,EIF4B,NUP98,SUMO2,SENP2,EIF4A1,SAP18,XPO1,NCBP2,NXF3,ACIN1,NUP54,EIF4A2,PABPC1,EIF4G2,RANBP2	31.3116279069767	4.490221e-04	0.023349152
hsa04510	Focal adhesion	Cell communication	203	61	PAK1,TLN1,COL4A5,PIK3R5,MYL12A,PTK2,BCL2,PIK3CB,TNXB,PPP1R12A,PDGFRB,PXN,EGF,XIAP,ITGA6,ITGB8,VEGFA,LAMA1,PIK3CD,ITGA2,PIP5K1C,GSK3B,SHC2,PARVG,EGFR,MYLK,MAPK8,PIK3R2,PPP1CB,ARHGAP5,LAMC2,ITGA7,ACTN1,ACTG1,BRAF,SOS1,PTEN,RAP1A,RAC2,ITGB4,COL4A3,PIK3R3,PPP1CC,ZYX,ITGB6,ITGAV,BCAR1,PAK3,CDC42,CHAD,PPP1R12B,RAP1B,PIK3CA,IGF1R,AKT1,COL6A1,RELN,COL6A6,VAV1,PAK2,BIRC3	41.5441860465116	6.480338e-04	0.028081464
hsa04120	Ubiquitin mediated proteolysis	Folding, sorting and degradation	137	44	KLHL13,UBE2G1,DDB1,ANAPC4,BRCA1,BIRC7,TRIP12,UBE2W,CUL4B,NEDD4L,XIAP,CUL3,PIAS1,WWP1,ANAPC10,CDC27,BIRC6,RCHY1,MDM2,TCEB1,UBE2Z,UBE2E2,CDC23,UBE3A,MGRN1,FZR1,UBE2F,FANCL,ANAPC7,UBA3,UBE2B,UBE4A,UBE2G2,CUL1,UBA6,PPIL2,UBE2E1,ANAPC5,FBXW11,UBA2,SAE1,UBE3C,UBE2J2,BIRC3	28.0372093023256	8.067546e-04	0.029965171
hsa00670	One carbon pool by folate	Metabolism of cofactors and vitamins	18	10	MTHFD2L,DHFR,MTHFD1,TYMS,ALDH1L1,SHMT2,GART,AMT,FTCD,ATIC	3.68372093023256	1.081151e-03	0.035137401
hsa00230	Purine metabolism	Nucleotide metabolism	164	50	POLR2G,PNPT1,GDA,ENTPD8,NT5C3B,PDE4D,NTPCR,AMPD3,POLD4,NME4,ENTPD6,PDE5A,PDE6B,NME5,POLR2J3,GUK1,ADCY4,IMPDH1,POLR3F,POLD3,PDE1B,POLR2E,APRT,POLA2,PDE6D,POLR2I,POLA1,PDE9A,NME6,PDE8A,GART,AK2,POLR3C,ADCY10,ADA,PDE2A,PRIM1,NUDT9,POLR2K,NME7,ENTPD4,HPRT1,ADK,POLR1D,POLR2H,NT5C2,PKM,RRM2B,GMPS,ATIC	33.5627906976744	1.366153e-03	0.039466647
hsa04012	ErbB signaling pathway	Signal transduction	85	29	PAK1,PIK3R5,PTK2,PIK3CB,EGF,MAP2K4,PIK3CD,GSK3B,SHC2,EGFR,MAPK8,PIK3R2,MAP2K7,NCK1,BRAF,SOS1,KRAS,NRAS,PIK3R3,MTOR,PAK3,RPS6KB2,CAMK2G,PIK3CA,CAMK2A,TGFA,AKT1,PAK2,RPS6KB1	17.3953488372093	2.198179e-03	0.053815476
hsa05214	Glioma	Cancers: Specific types	63	23	PIK3R5,PIK3CB,PDGFRB,EGF,PIK3CD,CALM2,SHC2,MDM2,EGFR,PIK3R2,BRAF,SOS1,PTEN,KRAS,NRAS,PIK3R3,MTOR,CAMK2G,PIK3CA,CAMK2A,IGF1R,TGFA,AKT1	12.893023255814	2.276809e-03	0.053815476
hsa04010	MAPK signaling pathway	Signal transduction	255	70	PAK1,CACNA2D1,FGFR1,MAP3K3,MKNK1,HSPA8,RPS6KA6,PDGFRB,JUND,EGF,CACNA1H,TAB2,LAMTOR3,PLA2G4C,NF1,FGF12,MAP2K4,TGFB1,CD14,CACNA1C,NTRK2,EGFR,RASA2,ATF2,MAPK8,MAP2K7,MAP3K12,FGF5,RASGRP4,RAPGEF2,MAP4K2,RPS6KA1,MAPK8IP3,IL1B,JMJD7-PLA2G4B,CACNG6,GNA12,MAP2K3,BRAF,MEF2C,SOS1,RAP1A,RAC2,CACNB3,FAS,RASGRP2,KRAS,NRAS,MAP4K1,RRAS2,CHUK,TGFBR1,CDC42,ATF4,GADD45G,CACNB4,MAPKAPK5,MAP2K5,RAP1B,PPM1B,IL1R2,MAP3K2,CACNA1A,CACNA1S,AKT1,DUSP16,CACNA2D4,PLA2G4B,DUSP9,PAK2	52.1860465116279	3.859373e-03	0.072711464
hsa04141	Protein processing in endoplasmic reticulum	Folding, sorting and degradation	164	48	UBE2G1,DAD1,BCL2,TRAM1,HSPA8,NFE2L2,SEC63,DNAJC1,DNAJB11,EIF2AK2,UGGT2,SEC24B,MAPK8,MAP2K7,MBTPS2,SSR2,NPLOC4,SSR1,UBE2E2,RPN2,SEC61B,SEC24A,EDEM3,CKAP4,SEC24D,SEC23B,DDOST,CRYAB,SEC31B,SSR3,MAN1C1,DNAJA1,ATXN3,ERLEC1,ATF4,SEC31A,UBE2G2,CUL1,PREB,MARCH6,UBE2E1,SIL1,HSP90B1,HSPH1,DNAJB12,BAX,UBE2J2,DNAJC10	33.5627906976744	4.194892e-03	0.072711464
hsa05215	Prostate cancer	Cancers: Specific types	88	29	FGFR1,PIK3R5,BCL2,PIK3CB,GSTP1,PDGFRB,EGF,PIK3CD,GSK3B,MDM2,EGFR,PIK3R2,CCNE2,BRAF,SOS1,PTEN,KRAS,NRAS,PIK3R3,MTOR,CHUK,ATF4,CREB5,PIK3CA,IGF1R,HSP90B1,TGFA,AKT1,TCF7	18.0093023255814	3.928794e-03	0.072711464
hsa03015	mRNA surveillance pathway	Translation	88	29	CSTF1,PPP2R3B,MAGOHB,SMG1,PABPN1,WDR33,PAPOLG,CPSF6,PPP2R2A,PPP1CB,RNPS1,DDX39B,NUDT21,CSTF3,MSI1,PPP1CC,PPP2R5C,PPP2R2C,SAP18,FIP1L1,PPP2R1A,NCBP2,MSI2,NXF3,ACIN1,SMG6,PPP2R3C,PABPC1,PPP2R5E	18.0093023255814	3.928794e-03	0.072711464
hsa05212	Pancreatic cancer	Cancers: Specific types	66	23	PIK3R5,PIK3CB,PLD1,EGF,VEGFA,PIK3CD,TGFB1,RALB,SMAD2,EGFR,MAPK8,PIK3R2,BRAF,RAC2,KRAS,PIK3R3,CHUK,TGFBR1,CDC42,SMAD4,PIK3CA,TGFA,AKT1	13.506976744186	4.495196e-03	0.073046927
hsa05213	Endometrial cancer	Cancers: Specific types	52	19	PIK3R5,PIK3CB,EGF,PIK3CD,GSK3B,CTNNA1,EGFR,PIK3R2,BRAF,SOS1,PTEN,KRAS,NRAS,PIK3R3,CTNNA3,PIK3CA,CDH1,AKT1,TCF7	10.6418604651163	5.263341e-03	0.080498162
hsa00240	Pyrimidine metabolism	Nucleotide metabolism	102	32	POLR2G,PNPT1,ENTPD8,NT5C3B,TYMS,POLD4,NME4,ENTPD6,DTYMK,NME5,POLR2J3,UPRT,POLR3F,POLD3,POLR2E,POLA2,POLR2I,POLA1,NME6,DPYS,POLR3C,TK1,PRIM1,POLR2K,NME7,CMPK1,ENTPD4,POLR1D,POLR2H,NT5C2,RRM2B,DCTD	20.8744186046512	5.888031e-03	0.085049331
hsa00790	Folate biosynthesis	Metabolism of cofactors and vitamins	13	7	QDPR,DHFR,ALPP,MOCS1,GGH,ALPL,PTS	2.66046511627907	7.927721e-03	0.103060371
hsa04810	Regulation of actin cytoskeleton	Cell motility	211	58	PAK1,FGFR1,PIK3R5,MYL12A,PTK2,PIK3CB,PPP1R12A,PDGFRB,PXN,EGF,FGF12,ITGA6,ITGB8,PIK3CD,ITGA2,ARPC1A,PIP5K1C,CD14,EGFR,MYLK,PIK3R2,PPP1CB,ARPC1B,FGF5,FGD3,ITGA7,ACTN1,GNA12,LIMK1,ACTG1,BRAF,ITGAL,SOS1,ARHGEF12,RAC2,ITGB4,CYFIP1,MYH9,KRAS,NRAS,PIK3R3,PFN2,PPP1CC,RRAS2,GSN,ITGB6,ITGAV,PIP5K1A,MYH10,BCAR1,PAK3,CDC42,PPP1R12B,PIK3CA,CHRM2,ARHGEF1,VAV1,PAK2	43.1813953488372	7.861663e-03	0.103060371
hsa05210	Colorectal cancer	Cancers: Specific types	62	21	PIK3R5,BCL2,PIK3CB,PIK3CD,TGFB1,GSK3B,SMAD2,MAPK8,PIK3R2,BRAF,RAC2,KRAS,PIK3R3,TGFBR1,SMAD4,PIK3CA,AKT1,TCF7,DCC,APPL1,BAX	12.6883720930233	9.309078e-03	0.106162632
hsa04722	Neurotrophin signaling pathway	Nervous system	117	35	IRAK1,MAP3K3,PIK3R5,FRS2,BCL2,PIK3CB,RPS6KA6,PIK3CD,CALM2,GSK3B,SHC2,NTRK2,MAPK8,PIK3R2,MAP2K7,RPS6KA1,MAGED1,BRAF,SOS1,RAP1A,KRAS,NRAS,PIK3R3,CDC42,NTRK3,ATF4,CAMK2G,MAP2K5,RAP1B,PIK3CA,CAMK2A,SH2B3,AKT1,IRAK4,BAX	23.9441860465116	9.302603e-03	0.106162632
hsa05142	Chagas disease (American trypanosomiasis)	Infectious diseases: Parasitic	101	31	IRAK1,PIK3R5,PIK3CB,MAP2K4,PIK3CD,TGFB1,SMAD2,PLCB4,MAPK8,PPP2R2A,PIK3R2,CD247,CFLAR,IL1B,PLCB2,FAS,CASP8,PIK3R3,CHUK,TGFBR1,PPP2R2C,ACE,PLCB1,PIK3CA,FADD,PPP2R1A,CD3G,GNA14,TLR9,AKT1,IRAK4	20.6697674418605	9.391310e-03	0.106162632
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	Cardiovascular diseases	74	24	CACNA2D1,ITGA6,ITGB8,ITGA2,DAG1,PKP2,CACNA1C,CTNNA1,ITGA7,ACTN1,CACNG6,ACTG1,CACNB3,ITGB4,DSG2,ITGB6,DES,ITGAV,CTNNA3,CACNB4,CACNA1S,RYR2,TCF7,CACNA2D4	15.1441860465116	1.026103e-02	0.111161145
hsa04070	Phosphatidylinositol signaling system	Signal transduction	79	25	PIK3R5,PIK3CB,OCRL,INPP5B,PIK3CD,CDS2,CALM2,PIP5K1C,PLCB4,PIK3R2,DGKA,PTEN,PLCB2,PIK3C3,PIK3R3,DGKZ,PIP5K1A,INPP1,ITPR1,PLCD4,DGKG,PLCB1,PIK3CA,PLCD3,INPP5A	16.1674418604651	1.242321e-02	0.124232087
hsa03008	Ribosome biogenesis in eukaryotes	Translation	71	23	RCL1,NAT10,NOP58,NOP10,CSNK2A2,BMS1,MPHOSPH10,XRN1,CSNK2A1,EIF6,WDR43,WDR75,UTP14A,DROSHA,HEATR1,NOP56,XPO1,FBL,NXF3,SPATA5,NVL,REXO2,GNL2	14.5302325581395	1.200420e-02	0.124232087
hsa04915	Estrogen signaling pathway	Endocrine system	96	29	PIK3R5,PIK3CB,HSPA8,FKBP4,GABBR1,ESR1,PIK3CD,CALM2,SHC2,PLCB4,EGFR,ATF2,PIK3R2,ADCY4,SOS1,PLCB2,KRAS,NRAS,PIK3R3,ITPR1,ATF4,CREB5,PLCB1,SP1,PIK3CA,HSP90B1,NOS3,OPRM1,AKT1	19.646511627907	1.475180e-02	0.142054403
hsa05211	Renal cell carcinoma	Cancers: Specific types	65	21	PAK1,PIK3R5,PIK3CB,VEGFA,PIK3CD,TGFB1,TCEB1,PIK3R2,BRAF,SOS1,RAP1A,KRAS,NRAS,PIK3R3,PAK3,CDC42,RAP1B,PIK3CA,TGFA,AKT1,PAK2	13.3023255813953	1.645951e-02	0.147568061
hsa04670	Leukocyte transendothelial migration	Immune system	117	34	PIK3R5,MYL12A,SIPA1,PTK2,PIK3CB,PXN,THY1,PIK3CD,CTNNA1,PIK3R2,CYBB,ARHGAP5,CTNND1,ACTN1,ACTG1,ITGAL,RAP1A,PTK2B,JAM3,CLDN4,CLDN11,RAC2,CLDN7,PIK3R3,BCAR1,CDC42,CTNNA3,RAPGEF4,PECAM1,RAP1B,PIK3CA,CXCL12,NOX1,VAV1	23.9441860465116	1.616703e-02	0.147568061
hsa05202	Transcriptional misregulation in cancer	Cancers: Overview	164	45	PAX7,ZEB1,WHSC1,PTK2,MLF1,FUS,TSPAN7,KDM6A,PBX1,ETV7,ASPSCR1,RUNX1T1,BAIAP3,FUT8,CD14,MDM2,CCNT1,NCOR1,HDAC1,TAF15,ETV1,BMP2K,MEF2C,CCNA1,RXRA,HOXA10,LMO2,CCNT2,DOT1L,HMGA2,SS18,SP1,IL1R2,IGF1R,HDAC2,LYL1,PROM1,HOXA9,JMJD1C,ETV5,PAX3,SIX1,ETV6,CSF1R,BIRC3	33.5627906976744	1.834595e-02	0.158998245
hsa04912	GnRH signaling pathway	Endocrine system	90	27	MAP3K3,PLD1,PLA2G4C,MAP2K4,CALM2,CACNA1C,PLCB4,EGFR,MAPK8,MAP2K7,ADCY4,JMJD7-PLA2G4B,MAP2K3,SOS1,PLCB2,PTK2B,KRAS,NRAS,ITPR1,CDC42,ATF4,CAMK2G,PLCB1,MAP3K2,CAMK2A,CACNA1S,PLA2G4B	18.4186046511628	1.993515e-02	0.167198030
hsa05010	Alzheimer*s disease	Neurodegenerative diseases	166	45	COX7A2L,MT-ATP6,ATP5H,SDHD,MME,CALM2,GSK3B,ATP2A3,NDUFB3,COX6A1,CACNA1C,PLCB4,NAE1,ATP5G3,NDUFA7,MT-CO1,IL1B,UQCRH,UQCRC2,RYR3,COX5A,PLCB2,FAS,NDUFS8,ATP5B,APBB1,CASP8,NDUFB4,UQCRB,ITPR1,ADAM10,NDUFB5,MT-CO3,NDUFB10,PLCB1,FADD,APH1A,CACNA1S,COX6B2,SDHC,MT-CO2,NDUFA3,NDUFA9,ATP5E,NDUFB9	33.9720930232558	2.259638e-02	0.180518482
hsa00514	Other types of O-glycan biosynthesis	Glycan biosynthesis and metabolism	29	11	LFNG,POGLUT1,ST6GAL1,PLOD3,OGT,FUT9,ST6GAL2,ST3GAL3,POFUT1,POMT2,MFNG	5.93488372093023	2.291196e-02	0.180518482
hsa04520	Adherens junction	Cell communication	68	21	FGFR1,CSNK2A2,SMAD2,CTNNA1,EGFR,FARP2,PTPN6,ACP1,CTNND1,ACTN1,ACTG1,CSNK2A1,RAC2,TGFBR1,CDC42,SMAD4,CTNNA3,CDH1,IGF1R,SSX2IP,TCF7	13.9162790697674	2.733720e-02	0.192099246
hsa05100	Bacterial invasion of epithelial cells	Infectious diseases: Bacterial	76	23	PIK3R5,CLTA,PTK2,PIK3CB,PXN,PIK3CD,ARPC1A,SHC2,CTNNA1,SEPT2,PIK3R2,ARPC1B,ACTG1,PIK3R3,SEPT9,BCAR1,CDC42,CTNNA3,CLTC,DNM3,PIK3CA,CDH1,SEPT1	15.553488372093	2.729517e-02	0.192099246
hsa04150	mTOR signaling pathway	Signal transduction	60	19	PIK3R5,PIK3CB,RPS6KA6,VEGFA,PIK3CD,EIF4E,PIK3R2,RPS6KA1,BRAF,RRAGB,PTEN,PIK3R3,MTOR,RPS6KB2,EIF4B,PIK3CA,ULK2,AKT1,RPS6KB1	12.2790697674419	2.696536e-02	0.192099246
hsa05203	Viral carcinogenesis	Cancers: Overview	189	50	DDB1,PIK3R5,GTF2H2,RBPJ,HDAC7,YWHAQ,USP7,PIK3CB,YWHAZ,PXN,HNRNPK,PIK3CD,TBPL2,EIF2AK2,MDM2,RASA2,ATF2,HDAC8,PIK3R2,CCNE2,GTF2B,HDAC1,UBE3A,ACTN1,UBR4,KAT2B,TRADD,CCNA1,ATP6V0D1,CASP8,KRAS,NRAS,HDAC9,PIK3R3,HIST1H2BN,GSN,CDC42,VDAC3,ATF4,PSMC1,POLB,CREB5,PIK3CA,TBPL1,HDAC2,PKM,GTF2H3,BAX,RBL1,HDAC6	38.6790697674419	2.629476e-02	0.192099246
hsa05221	Acute myeloid leukemia	Cancers: Specific types	57	18	PIK3R5,PIK3CB,RUNX1T1,PIK3CD,PIK3R2,BRAF,CCNA1,SOS1,KRAS,NRAS,PIK3R3,MTOR,CHUK,RPS6KB2,PIK3CA,AKT1,TCF7,RPS6KB1	11.6651162790698	3.165161e-02	0.213111505
hsa04720	Long-term potentiation	Nervous system	69	21	PPP1R12A,RPS6KA6,CALM2,CACNA1C,PLCB4,PPP1CB,RPS6KA1,BRAF,RAP1A,PLCB2,KRAS,NRAS,PPP1CC,ITPR1,ATF4,CAMK2G,PPP1R12B,PLCB1,RAP1B,CAMK2A,GRM5	14.1209302325581	3.196673e-02	0.213111505
hsa04110	Cell cycle	Cell growth and death	124	34	ANAPC4,YWHAQ,ATR,CDC6,YWHAZ,TGFB1,GSK3B,ANAPC10,WEE1,CDC27,SMAD2,CDC14B,MDM2,CCNB2,CCNE2,CDK7,MCM2,CDC23,HDAC1,ORC4,FZR1,CCNA1,SMC1A,DBF4,ANAPC7,E2F5,SMAD4,CUL1,GADD45G,HDAC2,ANAPC5,BUB1B,TTK,RBL1	25.3767441860465	3.718007e-02	0.224809712
hsa03460	Fanconi anemia pathway	Replication and repair	50	16	POLK,BRCA1,ATR,FANCA,UBE2T,TELO2,RPA3,FANCD2,POLI,FANCL,RAD51C,REV1,RMI1,BRIP1,FANCI,PMS2	10.2325581395349	3.676085e-02	0.224809712
hsa04664	Fc epsilon RI signaling pathway	Immune system	70	21	PIK3R5,PIK3CB,BTK,PLA2G4C,MAP2K4,PIK3CD,LAT,MAPK8,PIK3R2,MAP2K7,JMJD7-PLA2G4B,MAP2K3,SOS1,RAC2,KRAS,NRAS,PIK3R3,PIK3CA,AKT1,PLA2G4B,VAV1	14.3255813953488	3.715898e-02	0.224809712
hsa04914	Progesterone-mediated oocyte maturation	Endocrine system	86	25	ANAPC4,PIK3R5,PIK3CB,CPEB1,RPS6KA6,PIK3CD,SPDYA,ANAPC10,CDC27,CCNB2,MAPK8,PIK3R2,CDC23,RPS6KA1,ADCY4,BRAF,FZR1,CCNA1,KRAS,PIK3R3,ANAPC7,PIK3CA,IGF1R,ANAPC5,AKT1	17.6	3.550424e-02	0.224809712
hsa04370	VEGF signaling pathway	Signal transduction	67	20	PIK3R5,PTK2,PIK3CB,PXN,PLA2G4C,VEGFA,PIK3CD,SHC2,PIK3R2,JMJD7-PLA2G4B,NFATC1,RAC2,KRAS,NRAS,PIK3R3,CDC42,PIK3CA,NOS3,AKT1,PLA2G4B	13.7116279069767	4.338270e-02	0.256352289
hsa03440	Homologous recombination	Replication and repair	28	10	RAD54B,POLD4,RPA3,POLD3,XRCC3,RAD52,RAD51C,RAD54L,SHFM1,SSBP1	5.73023255813953	4.462640e-02	0.257841423
hsa04114	Oocyte meiosis	Cell growth and death	109	30	ANAPC4,YWHAQ,CPEB1,AURKA,YWHAZ,RPS6KA6,SPDYA,CALM2,ANAPC10,CDC27,CCNB2,CCNE2,PPP1CB,CDC23,RPS6KA1,ADCY4,SMC1A,PPP1CC,ANAPC7,PPP2R5C,ITPR1,CAMK2G,STAG3,CUL1,CAMK2A,PPP2R1A,IGF1R,ANAPC5,FBXW11,PPP2R5E	22.306976744186	4.597847e-02	0.259878303
hsa04662	B cell receptor signaling pathway	Immune system	76	22	PIK3R5,PIK3CB,BTK,CD79B,PIK3CD,GSK3B,BLNK,PIK3R2,PTPN6,CD22,SOS1,MALT1,NFATC1,RAC2,KRAS,NRAS,PIK3R3,CHUK,PIK3CA,CD81,AKT1,VAV1	15.553488372093	4.858852e-02	0.268787560