Pathway_id	Pathway_name	Pathway_class	Annotated	Significant	SymbolList	Expected	classic_fisher	FDR
hsa05205	Proteoglycans in cancer	Cancers: Overview	224	52	CD44,MMP2,PLCE1,PRKCG,FGFR1,PDCD4,PTK2,EZR,FGF1,TIAM1,PXN,WNT6,FGF12,PRKACB,PIK3CD,MYC,RPS6,EGFR,HOXD10,HOXC10,THBS1,PTPN6,TWIST2,CAV2,TLR2,ACTG1,WNT7B,AKT3,SOS2,KRAS,PIK3R3,FZD7,ANK2,ITGAV,HOXA10,ITPR1,PTCH1,ITPR2,FGF14,EIF4B,IGF2,ERBB3,IQGAP1,FGF2,WNT10A,MAPK3,PDK1,AKT1,ITGB3,ARAF,PRKCA,ITPR3	28.48949478749	7.431711e-06	0.00190995
hsa04270	Vascular smooth muscle contraction	Circulatory system	118	29	KCNMA1,PLA2G2C,PRKCG,GNAS,EDNRA,PRKACB,GNA13,CACNA1C,CALML5,PLA2G2D,MYL9,PRKCH,JMJD7-PLA2G4B,ADORA2A,ADCY5,MYH11,ITPR1,ITPR2,PLA2G2F,PLA2G5,CALML3,CALCRL,MAPK3,KCNMB2,ARAF,PLA2G4B,ADCY9,PRKCA,ITPR3	15.007858861267	2.829959e-04	0.03636497
hsa05223	Non-small cell lung cancer	Cancers: Specific types	54	15	PRKCG,RASSF5,RARB,PIK3CD,EGFR,AKT3,SOS2,KRAS,PIK3R3,PDPK1,MAPK3,AKT1,ARAF,CDKN2A,PRKCA	6.86800320769848	2.297417e-03	0.12092932
hsa05202	Transcriptional misregulation in cancer	Cancers: Overview	164	34	ZEB1,FEV,PTK2,MLF1,MEIS1,FLI1,MYC,NR4A3,FOXO1,FUT8,SMAD1,RUNX2,MAF,HOXA11,PAX5,EYA1,HOXA10,LMO2,SUPT3H,PER2,HPGD,CCNT2,DOT1L,HMGA2,RARA,DUSP6,SIX4,HDAC2,HOXA9,JMJD1C,SIX1,ETV6,CEBPB,ARNT2	20.8583801122694	2.352710e-03	0.12092932
hsa04724	Glutamatergic synapse	Nervous system	114	26	PRKCG,GNAS,GNB4,GNAO1,DLGAP1,PRKACB,GRIN2A,CACNA1C,GNG7,GRM7,SLC1A3,SHANK2,JMJD7-PLA2G4B,GRM8,ADCY5,SLC1A2,SLC38A2,ITPR1,ITPR2,HOMER2,MAPK3,GNB5,PLA2G4B,ADCY9,PRKCA,ITPR3	14.499117882919	1.871438e-03	0.12092932
hsa04713	Circadian entrainment	Environmental adaptation	94	22	PRKCG,GNAS,GNB4,GNAO1,CACNA1H,PRKACB,GRIN2A,CACNA1C,CALML5,GNG7,RYR3,ADCY5,ITPR1,PER2,PER3,MTNR1A,CALML3,MAPK3,GNB5,ADCY9,PRKCA,ITPR3	11.9554129911788	2.895854e-03	0.12403907
hsa05222	Small cell lung cancer	Cancers: Specific types	86	20	PTK2,BCL2,BIRC7,RARB,LAMB3,PTGS2,ITGA6,CDKN2B,LAMA1,PIK3CD,MYC,LAMA3,CCNE2,AKT3,LAMA2,COL4A3,PIK3R3,ITGAV,AKT1,LAMA4	10.9379310344828	4.756490e-03	0.12888470
hsa04151	PI3K-Akt signaling pathway	Signal transduction	342	60	FGFR1,PPP2R3B,PTK2,YWHAQ,BCL2,FGF1,GNB4,LAMB3,OSM,FGF12,ITGA6,ITGB8,LAMA1,PIK3CD,MYC,LAMA3,RPS6,EGFR,NR4A1,IL4,THBS1,CCNE2,GNG7,IL4R,G6PC,TLR2,AKT3,LAMA2,PHLPP2,OSMR,THBS3,SOS2,KRAS,COL4A3,PIK3R3,ITGAV,PDPK1,PPP2R5C,RBL2,MCL1,CCND3,FGF14,ANGPT2,EIF4B,BCL2L11,IL3RA,FGF2,PPP2R1A,COL2A1,MAPK3,THBS2,CHRM2,GNB5,AKT1,ITGB3,COL6A1,KITLG,LAMA4,PRKCA,IL7	43.497353648757	5.014969e-03	0.12888470
hsa04510	Focal adhesion	Cell communication	203	39	PRKCG,MYL12A,PTK2,BCL2,LAMB3,PXN,ITGA6,ITGB8,LAMA1,PIK3CD,LAMA3,DOCK1,MYL12B,TLN2,EGFR,THBS1,MYL9,CAV2,ACTN1,ACTG1,AKT3,LAMA2,RAP1A,THBS3,SOS2,COL4A3,PIK3R3,ITGAV,PDPK1,CCND3,COL2A1,MAPK3,THBS2,AKT1,ITGB3,COL6A1,LAMA4,JUN,PRKCA	25.8186046511628	4.845351e-03	0.12888470
hsa04912	GnRH signaling pathway	Endocrine system	90	21	MMP2,GNAS,GNRHR,PRKACB,CACNA1C,CALML5,EGFR,MAP2K7,JMJD7-PLA2G4B,SOS2,ADCY5,KRAS,ITPR1,ITPR2,CALML3,MAPK3,PLA2G4B,JUN,ADCY9,PRKCA,ITPR3	11.4466720128308	3.710490e-03	0.12888470
hsa04730	Long-term depression	Nervous system	60	15	PRKCG,GNAS,GNAO1,GNA13,CRH,JMJD7-PLA2G4B,KRAS,ITPR1,ITPR2,PPP2R1A,MAPK3,ARAF,PLA2G4B,PRKCA,ITPR3	7.63111467522053	6.807971e-03	0.15905897
hsa00601	Glycosphingolipid biosynthesis - lacto and neolacto series	Glycan biosynthesis and metabolism	25	8	B3GALT5,GCNT2,FUT3,FUT7,B4GALT1,ST8SIA1,ST3GAL6,ST3GAL3	3.17963111467522	9.787036e-03	0.19480716
hsa04725	Cholinergic synapse	Nervous system	112	23	PRKCG,BCL2,GNB4,GNAO1,PRKACB,PIK3CD,CACNA1C,GNG7,CHRNA3,AKT3,ADCY5,KRAS,CHRNB4,PIK3R3,ITPR1,ITPR2,MAPK3,CHRM2,GNB5,AKT1,ADCY9,PRKCA,ITPR3	14.244747393745	1.256627e-02	0.19480716
hsa05200	Pathways in cancer	Cancers: Overview	324	55	MMP2,PRKCG,FGFR1,BIRC5,MSH6,PTK2,BCL2,BIRC7,RASSF5,FGF1,RARB,LAMB3,WNT6,PTGS2,FGF12,ITGA6,CDKN2B,LAMA1,PIK3CD,MYC,LAMA3,FOXO1,EGFR,CCNE2,EPAS1,WNT7B,AKT3,RALBP1,LAMA2,SOS2,KRAS,COL4A3,PIK3R3,FZD7,ITGAV,BMP4,PTCH1,CTNNA3,FGF14,RARA,FGF2,WNT10A,MAPK3,HDAC2,CTBP2,CUL2,AKT1,KITLG,LAMA4,ARAF,CDKN2A,JUN,BAX,PRKCA,ARNT2	41.2080192461909	1.364408e-02	0.19480716
hsa04720	Long-term potentiation	Nervous system	69	16	PRKCG,PRKACB,GRIN2A,RPS6KA2,CACNA1C,CALML5,RAP1A,KRAS,ITPR1,ITPR2,CALML3,MAPK3,ARAF,PRKCA,RPS6KA3,ITPR3	8.77578187650361	1.125581e-02	0.19480716
hsa04664	Fc epsilon RI signaling pathway	Immune system	70	16	PIK3CD,IL4,MAP2K7,LCP2,JMJD7-PLA2G4B,AKT3,SOS2,KRAS,PIK3R3,FCER1A,GAB2,MAPK3,PDK1,AKT1,PLA2G4B,PRKCA	8.90296712109062	1.292454e-02	0.19480716
hsa05110	Vibrio cholerae infection	Infectious diseases: Bacterial	53	13	PRKCG,GNAS,ATP6V1C1,PRKACB,ACTG1,ATP6V0D1,SLC12A2,TJP1,TCIRG1,PDIA4,ADCY9,ATP6V1B1,PRKCA	6.74081796311147	1.336794e-02	0.19480716
hsa04910	Insulin signaling pathway	Endocrine system	137	27	PRKACB,PIK3CD,SOCS3,FOXO1,CALML5,RPS6,SOCS1,G6PC,SREBF1,AKT3,SOS2,LIPE,KRAS,PIK3R3,FLOT2,PPP1R3B,PRKAR1A,PDPK1,PTPN1,PYGL,CALML3,HK2,MAPK3,FLOT1,AKT1,PRKAB1,ARAF	17.4243785084202	1.250540e-02	0.19480716
hsa04972	Pancreatic secretion	Digestive system	95	20	KCNMA1,PLA2G2C,PRKCG,GNAS,FXYD2,SCTR,PLA2G2D,RAP1A,ADCY5,SLC12A2,RAB27B,TPCN2,ITPR1,ITPR2,PLA2G2F,PLA2G5,ADCY9,PRKCA,ITPR3,RAB8A	12.0825982357658	1.472282e-02	0.19914546
hsa04915	Estrogen signaling pathway	Endocrine system	96	20	MMP2,GNAS,GNAO1,PRKACB,PIK3CD,CALML5,EGFR,AKT3,SOS2,ADCY5,KRAS,PIK3R3,ITPR1,ITPR2,CALML3,MAPK3,AKT1,JUN,ADCY9,ITPR3	12.2097834803528	1.645355e-02	0.21142809
hsa00071	Fatty acid metabolism	Lipid metabolism	44	11	ALDH2,ADH5,ACAA2,ACOX3,ACADM,ADH4,CPT1A,ACSL5,ACADS,ADH1A,ADH6	5.59615076182839	1.914246e-02	0.23426725
hsa04960	Aldosterone-regulated sodium reabsorption	Excretory system	39	10	PRKCG,FXYD2,SCNN1B,PIK3CD,SCNN1G,KRAS,PIK3R3,PDPK1,MAPK3,PRKCA	4.96022453889334	2.101334e-02	0.24547402
hsa05213	Endometrial cancer	Cancers: Specific types	52	12	PIK3CD,MYC,EGFR,AKT3,SOS2,KRAS,PIK3R3,PDPK1,CTNNA3,MAPK3,AKT1,ARAF	6.61363271852446	2.717313e-02	0.24941055
hsa04727	GABAergic synapse	Nervous system	88	18	SLC6A11,PRKCG,GNB4,GNAO1,GABRG3,PRKACB,CACNA1C,SLC6A1,GNG7,GPHN,ADCY5,SLC38A2,GABRR1,GNB5,GABARAPL2,GAD1,ADCY9,PRKCA	11.1923015236568	2.633760e-02	0.24941055
hsa05214	Glioma	Cancers: Specific types	63	14	PRKCG,PIK3CD,CALML5,EGFR,AKT3,SOS2,KRAS,PIK3R3,CALML3,MAPK3,AKT1,ARAF,CDKN2A,PRKCA	8.01267040898156	2.442985e-02	0.24941055
hsa04320	Dorso-ventral axis formation	Development	24	7	EGFR,SOS2,ETS2,PIWIL1,KRAS,MAPK3,ETV6	3.05244587008821	2.578370e-02	0.24941055
hsa04141	Protein processing in endoplasmic reticulum	Folding, sorting and degradation	164	30	BAK1,BCL2,NFE2L2,UBQLN2,RPN1,MAN1A2,ATXN3L,AMFR,DNAJC5B,MAP2K7,MAN1B1,UBE2E3,MBTPS1,BAG1,HSPA4L,STUB1,MAN1C1,PLAA,SEC31A,UBE2D1,SEC23A,ERP29,BAG2,ATF6,UBQLN1,UBXN6,PDIA4,ERN1,BAX,UBE2J2	20.8583801122694	2.395753e-02	0.24941055
hsa04810	Regulation of actin cytoskeleton	Cell motility	211	37	FGFR1,MYL12A,PTK2,EZR,FGF1,TIAM1,PXN,FGF12,ITGA6,ITGB8,ITGB2,PIK3CD,GNA13,DOCK1,DIAPH3,MYL12B,ITGAD,EGFR,MYL9,ACTN1,ACTG1,CYFIP2,ITGAL,DIAPH2,SOS2,KRAS,PIK3R3,PFN2,GSN,ITGAV,FGF14,IQGAP1,FGF2,MAPK3,CHRM2,ITGB3,ARAF	26.8360866078589	2.459031e-02	0.24941055
hsa05414	Dilated cardiomyopathy	Cardiovascular diseases	90	18	SLC8A1,GNAS,ITGA6,ITGB8,PRKACB,CACNA2D2,CACNA1C,CACNB2,ACTG1,LAMA2,ADCY5,ITGAV,TPM4,SGCA,TTN,ITGB3,CACNA2D4,ADCY9	11.4466720128308	3.238389e-02	0.24949206
hsa04668	TNF signaling pathway	Signal transduction	109	21	LIF,TAB2,PTGS2,PIK3CD,SOCS3,TNFAIP3,MAP2K7,ITCH,CFLAR,NOD2,AKT3,PIK3R3,CCL2,MAGI2,RIPK1,ICAM1,MAPK3,AKT1,BCL3,CEBPB,JUN	13.863191659984	3.219852e-02	0.24949206
hsa05032	Morphine addiction	Substance dependence	90	18	PRKCG,GNAS,PDE4C,GNB4,GNAO1,GABRG3,PRKACB,PDE7B,PDE7A,PDE10A,GNG7,GRK6,ADCY5,GABRR1,GNB5,PDE8B,ADCY9,PRKCA	11.4466720128308	3.238389e-02	0.24949206
hsa04012	ErbB signaling pathway	Signal transduction	85	17	PRKCG,PTK2,PIK3CD,MYC,EGFR,MAP2K7,NCK1,AKT3,SOS2,KRAS,PIK3R3,ERBB3,MAPK3,AKT1,ARAF,JUN,PRKCA	10.8107457898957	3.688988e-02	0.24949206
hsa04722	Neurotrophin signaling pathway	Nervous system	117	22	BCL2,PIK3CD,RPS6KA2,CALML5,MAP2K7,NTF3,AKT3,RAP1A,BDNF,SOS2,KRAS,PRDM4,TP73,RIPK2,PIK3R3,CALML3,MAPK3,PDK1,AKT1,JUN,BAX,RPS6KA3	14.88067361668	3.688482e-02	0.24949206
hsa04150	mTOR signaling pathway	Signal transduction	60	13	PRKCG,RICTOR,PIK3CD,RPS6KA2,RPS6,AKT3,PIK3R3,PDPK1,EIF4B,MAPK3,AKT1,PRKCA,RPS6KA3	7.63111467522053	3.566648e-02	0.24949206
hsa04670	Leukocyte transendothelial migration	Immune system	117	22	MMP2,PRKCG,MYL12A,PTK2,RHOH,RASSF5,EZR,PXN,THY1,ITGB2,PIK3CD,MYL12B,ESAM,MYL9,ACTN1,ACTG1,ITGAL,RAP1A,PIK3R3,CTNNA3,ICAM1,PRKCA	14.88067361668	3.688482e-02	0.24949206
hsa00592	alpha-Linolenic acid metabolism	Lipid metabolism	25	7	PLA2G2C,ACOX3,PLA2G2D,JMJD7-PLA2G4B,PLA2G2F,PLA2G5,PLA2G4B	3.17963111467522	3.200462e-02	0.24949206
hsa05034	Alcoholism	Substance dependence	141	26	GNAS,HIST1H2BJ,GNB4,GNAO1,HIST1H4I,H2BFWT,GRIN2A,HIST1H2AG,CALML5,CRH,HIST1H2BK,GNG7,PKIA,SLC6A3,BDNF,SOS2,ADORA2A,ADCY5,KRAS,CALML3,MAPK3,HDAC2,GNB5,HIST1H2AH,ARAF,H2AFY	17.9331194867682	3.100094e-02	0.24949206
hsa04970	Salivary secretion	Digestive system	85	17	KCNMA1,PRKCG,GNAS,FXYD2,MUC5B,PRKACB,CALML5,RYR3,ADCY5,SLC12A2,PRB2,ITPR1,ITPR2,CALML3,ADCY9,PRKCA,ITPR3	10.8107457898957	3.688988e-02	0.24949206
hsa00564	Glycerophospholipid metabolism	Lipid metabolism	86	17	PLA2G2C,PLA2G2D,JMJD7-PLA2G4B,LPIN1,PGS1,PTDSS2,LPCAT1,CRLS1,LPGAT1,CHKB,LPCAT2,CHKA,PLA2G2F,DGKI,PLA2G5,ADPRM,PLA2G4B	10.9379310344828	4.075949e-02	0.26859458
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	Cardiovascular diseases	74	15	SLC8A1,ITGA6,ITGB8,CACNA2D2,CACNA1C,CACNB2,ACTN1,ACTG1,LAMA2,DSG2,ITGAV,CTNNA3,SGCA,ITGB3,CACNA2D4	9.41170809943865	4.328037e-02	0.27807639
hsa05210	Colorectal cancer	Cancers: Specific types	62	13	BIRC5,MSH6,BCL2,PIK3CD,MYC,AKT3,KRAS,PIK3R3,MAPK3,AKT1,ARAF,JUN,BAX	7.88548516439455	4.526433e-02	0.28373008
hsa04540	Gap junction	Cell communication	88	17	PRKCG,GNAS,TUBB,PRKACB,TUBB2B,EGFR,SOS2,ADCY5,KRAS,ITPR1,TJP1,ITPR2,TUBB2A,MAPK3,ADCY9,PRKCA,ITPR3	11.1923015236568	4.936140e-02	0.30204475