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{"sheet":"Supplementary information","index":0,"n_rows":5,"n_cols":2,"rows_kept":5,"cut":false,"hidden":false,"merged":[]}
[]
["GWAS mental disorders","Overview of sample sizes, number of total, genome-wide significant SNPs, and relevant results of GWAS and GWAMA for BMI, mental disorders, and related quantitative phenotypes"]
["GWAS metabolites","Overview of sample sizes, metabolic traits and subcategories thereof, investigated compartment, and number of genome-wide significant SNPs in GWAS and GWAMA on metabolic traits "]
["Gene information","Information on gene functions"]
["Associations","Associations (p < 0.05) of human metabolism SNPs with BMI, mental disorders, and related quantitative phenotypes"]

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["Supplemental Tab 1: Overview of sample sizes, number of total, genome-wide significant SNPs, and relevant results of GWAS and GWAMA for BMI, mental disorders, and related quantitative phenotypes."]
[]
["Author","Trait","Number of subjects ","Number of controls","Genome wide significant identified loci           (P ≤ 5×10-8)","Number of SNPs ","Number of SNPs p ≤ 0.05","Effect chanceA ","Full summary statistics publically available"]
["Locke et al. 2015","Body Mass Index",339224,null,97,2554623,181905,"7.1%","yes"]
["Okbay et al. 2016","Educational attainment","293723 + replication study 111349 ",null,74,81468849,837322,"10.3%","yes"]
["Okbay et al. 2016","Neuroticism",170911,null,11,6524432,540840,"8.3%","yes"]
["Lambert et al. 2013","Alzheimer",17008,37154,19,7055544,438696,"6.2%","yes"]
["Ripke et al. 2014","Schizophrenia",36989,113075,108,8624491,990228,"11.5%","yes"]
["Okbay et al. 2016","Well-being",298420,null,3,2268674,157714,"7.0%","yes"]
["Pappa et al. 2016","Aggressive behavior ",18988,null,0,2188528,113720,"5.2%","yes"]
["Otowa et al. 2016","Anxiety disorders",18186,null,1,6330995,340614,"5.4%","yes"]
["Okbay et al. 2016","Depressive Symptoms",161460,null,2,6524474,419949,"6.4%","yes"]
["Ripke et al. 2013","Major depressive disorder",9240,9519,0,1235109,69867,"5.7%","yes"]
["Sklar et al. 2013","Bipolar disorder",7481,9250,2,2427220,168699,"7.0%","yes"]
["The Autism Spectrum Disorders Working Group of The Psychiatric Genomics Consortium 2017","Autism spectrum disorder",5305,"5305 pseudocontrols",1,8642525,456396,"5.3%","yes"]
["Benke et al. 2014","Internalizing problems",4596,null,0,2821734,144906,"5.1%","yes"]
["Neale et al. 2010","Attention Deficit/Hyperactivity Disorder","2064 trios + 896 cases",2455,0,1206461,63807,"5.3%","yes"]
["AProportion of SNPs p<0.05"]

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["Supplemental Tab 2: Overview of sample sizes, metabolic traits and subcategories thereof, investigated compartment, and number of genome-wide significant SNPs in GWAS and GWAMA on metabolic traits "]
[]
["First Author","Journal, Year","Number of subjects (n)","Metabolic traits","Metabolic sub-categories","Compartment","Genome-wide significant identified loci  (P ≤ 5×10-8)","max R2","lowest p-value","Full summary statistics publically available"]
["Gieger C","PLoS Genetics, 2008","284 males","Metabolite levels / ratios","Sugar molecules, biogenic amines, prostaglandins, acylcarnitines, sphingolipids, glycerophospholipids","Blood",5,"met levels: 12.0 % (ratios: 28.6 %)","met levels: 1.95 x 10-9 (ratios: 2.4 x 10-22)","no"]
["Hazra A","Human Molecular Genetics, 2009","3,305 females, 1,458 males","Folate pathway vitamin levels","Folate, vitamin B12, homocystein","Blood",7,"not reported","1.40 x 10-15","no"]
["Chasman DI","PLoS Genetics, 2009","17,296 females","Lipid metabolism phenotypes","Lipoprotein measures","Blood","43 (10 novel)","8.9 %","3.3 x 10-93","no"]
["Illig T","Nature Genetics, 2010","1,809 (422 replication)","Metabolite levels / ratios","Amino acids, hexose, forms of carnitine, sphingomyelins,  N-hydroxylacyloylsphingosylphosphocholine, phosphatidylcholines, lyso-phosphatidylcholines","Blood",15,"met ratios: 36.3 % ","met ratios: 6.5 x 10-179","no"]
["Kamatani Y","Nature Genetics, 2010",14.805999999999999,"Hematological and biochemical traits","Number of white blood cells, red blood cell traits, plateled counts, urate, lipids, Gamma glutamyl transferase, Alkaline phosphatase, Aspartate aminotransferase, Alanine aminotransferase, Creatine kinase, Total protein, Albumin, Blood urea nitrogen, Serum Creatinin, ","Blood","89 (46 novel) ","3.79 %","2.82 x 10-66","no"]
["Chambers JC","Nature Genetics, 2010","23,812 (16,626 replication)","Creatinine levels","Serum creatinine","Blood","5 (4 novel)","not reported","1.2 x 10-15","no"]
["Köttgen A","Nature Genetics, 2010","67,093 (22,982 replication)","Chronic kidney disease","Serum creatinine, cystatin C, CKD (=eGFRcrea <60 ml/min/1.73m2)","Blood","28 (23 novel)","not reported","2.3 x 10-138","no"]
["Wang TJ","Lancet, 2010","16,125 (17,744 replication)","Vitamin D insufficiency","25-OH vitamin D","Blood",4,"not reported","1.9 x  10-109","no"]
["Böger CA","J Am Soc Nephrol, 2011",63.152999999999999,"Urinary albumin excretion ratios","Microalbuminuria, albumin-to-creatinine ratio","Urine",1,"0.15 %","1.1 x 10-11","no"]
["Suhre K","Nature Gen, 2011","862 males (2031 males and females replication) ","Urinary metabolites / ratios",null,"Urine",5,"33.4 %","2.1 x 10-182","no"]
["Suhre K","Nature, 2011",2.82,"Metabolic traits","Amino acids, acylcarnitines, sphingomyelins, glycerophospholipids, carbohydrates, vitamins, lipids, nucleotides, peptide, xenobiotics, steroids","Blood","37 (15 novel)","not reported","4.4 x 10-305","no"]
["Kim YJ","Nature Genetics, 2011","12,545 (30,395 replication)","Metabolite levels","Liver enzymes, plasma lipids, renal-function-related traits, glycemic traits, ","Blood","33 SNPs (10 novel)","not reported ","2.9 x 10-126","no"]
["Nicholson G","PLoS Genetics, 2011","144 female twins + 69","Metabolite levels",null,"Blood, urine",4,0.64,"2.8 x 10-23","no"]
["Kettunen J","Nature Genetics, 2012",8.33,"Metabolite levels /ratios ","Lipoproteins, lipids, amino acids, low-molecular-weight metabolites","Blood","31 (11 novel)",0.25,"8.0 x 10-262","no"]
["Pierce BL","PLoS Genetics, 2012",1.3129999999999999,"Arsenic metabolism","Arsenic metabol concentrations","Urine",1,"not reported","2.7 x 10-9 ","no"]
["Inouye M","PLoS Genetics, 2012",6.6079999999999997,"Metabolite levels","Lipoproteins, lipids, amino acids and other small molecules","Blood","34 (7 novel)","not reported","3.9 x10-264","no"]
["Hong MG","Human Mutation, 2013","402 (489 replication)","Metabolite levels",null,"Blood","7 (4 novel)",0.46,"2.4 x 10-91","no"]
["Xie W","Diabetes, 2013","1,004 (342 replication)","Metabolite levels / ratio","insulin sensitivity-related metabolites","Blood","5 (3 novel)","12.9 %","3.3 x10-50","no"]
["Yu B","Genetic Epidemiology, 2013",1.26,"Metabolite levels","pyroglutamine, dihydroxy docosatrienoic acid, X-11787 (risk factors of incident heart failure)","Blood",2,"not reported","9.6 x 10-24","no"]
["An P","Metabolism, 2014","4,088 (8,231 replication)","Glycated hemoglobin levels","HbA1c","Blood",4,"not reported","1.8 x 10-11","no"]
["Olden M","J Am Soc Nephrol, 2014",10.884,"Urinary uromodulin levels","Uromodulin","Urine",1,"1.2 %","7.9 x 10-73","no"]
["Rueedi R","PLoS Genetics, 2014","835 (601 replication)","Urinary metabolites (H-NMR features)",null,"Urine","11 (2 novel)","27.8%","3.4 x 10-209","no"]
["Yu B","Plos Genetics, 2014",1.26,"Serum metabolite levels",null,"Blood","19 (13 novel)",0.2,"4 x 10-66","no"]
["Williams SR","Plos Genetics, 2014",4.8099999999999996,"Methionine metabolism","Plasma homocysteine levels (post-methionine load test)","Blood",5,"not reported","1.6 x 10-63","no"]
["Shin SY","Nature Genetics, 2014",7.8239999999999998,"Blood metabolite levels / ratios",null,"Blood","145 (84 novel)",0.62,"3.0 x 10-860","yes"]
["Korostishevsky M","European Journal of Human Genetics, 2016","3,953 female twins (101 singletons, 1,156 dizygotic, and 770 monozygotic twin pairs)","Blood metabolite levels","Metabolites associated with appendicular lean mass","Blood",4,"10.5 %","2.1 x 10-59","no"]
["Ruth KS","European Journal of Human Genetics, 2016","2,913 twins","Sex hormone levels","dehydroepiandrosterone sulphate (DHEAS), oestradiol, free androgen index (FAI), follicle-stimulating hormone (FSH), luteinizing hormone (LH), prolactin, progesterone, sex hormone-binding globulin and testosterone","Blood","8 (3 novel)","not reported","1.2 x10-15","no"]
["Draisma HH","Nature Communication, 2015","7,478 (1,182 replication)","Metabolite levels","Acylcarnitins, amino acids, glycerophospholipids, sphingolipids, hexose","Blood","59 (5 novel)","12.9 %","2.0 x 10-175 ","yes"]
["Wojczynski MK","Metabolism, 2015","872 (843 replication)","Postprandial triglyceride response to high fat diet meal",null,"Blood",1,"not reported","1.3 x 10-9","no"]
["Raffler J","PLoS Genetics, 2015","3,861 (1,691 replication)","Urinary metabolites",null,"Urine (+ blood)","22 (15 novel)","not reported","<1.0 x 10-307","yes"]
["Teumer A","Diabetes, 2016",51.886000000000003,"Urinary metabolites / ratios","albumin, creatinine, microalbuminuria, albumin-to-creatinine ratio","Urine",1,0.31,"1.3 x 10-10","yes"]
["Pattaro C","Nature Communication, 2016","133,413 (42,166 replication)","Estimated glomerular filtration rate","Serum creatinine, serum cystatin","Blood","53 (24 novel)","not reported","9.5 x 10-43","yes"]
[]
["  "]

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["Supplemental Tab 3: Information on gene functionsA"]
[]
["Gene name abbreviation","Gene product","Gene product function","Most associated metabolite or ratioB","Associated disease and/or inborn error metabolism[i] "]
[]
["SDCCAG8","SDCCAG8 (Serologically Defined Colon Cancer Antigen 8) ","Related pathways are regulation of PLK1 activity at G2/M transition; participation in organelle biogenesis and maintenance. SDCCAG8 plays a structural role in the centrosomal architecture, it is located at the ends of both centrioles and co-localizes to centrosomes throughout the cell cycle. SDCCAG8 is also localized to cell-cell junctions. A role for this protein in DNA damage repair is also suggested ","Estimated Glomerular filtration rate (creatinine); eGFRcrea","Associated diseases are Senior-Loken syndrome (a nephronophthisis-related ciliopathy) and Bardet-Biedl syndrome. "]
["ALMS1","ALMS1 (ALMS1, Centrosome And Basal Body Associated Protein) ","Related pathways are regulation of PLK1 activity at G2/M transition, participation in organelle biogenesis and maintenance. Involved in intracellular transport and proper formation of primary cilia (PC)","N-acetylated compounds","Associated diseases encompass Alstrom syndrome and acanthosis nigricans. Depletion of Alms1 in mice caused defective ciliogenesis."]
["NAT8","NAT8 (N-Acetyltransferase 8 (Putative))","Related pathways are cytochrome P450 - arranged by substrate type and glutathione metabolism. Transfers acyl groups other than amino-acyl groups e.g. N-acetylation of S-benzyl-L-cysteine in the presence of acetyl-CoA to form mercapturic acids which are water soluble and can be readily excreted in urine or bile, as a final step in a major route for detoxification of a wide variety of reactive electrophiles. NAT8 was not found to be active against other L-amino acids. About 100-fold lower activity was found with leukotriene E4 as substrate; weak lysine N-acetyl-transferase activity. Thereby, potential involvement in regulation of apoptosis. May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and subsequent expression regulation. Based on the expression pattern and structure, NAT8 seems to play an important role in the development and maintenance of normal kidney and liver structure and function. \nOverexpression of wildtype or catalytically inactive NAT8 caused cell death in HEK293T cells, suggesting that toxicity is not linked to NAT8 catalytic activity.\n","N-acetylornithine","Associated diseases include hemorrhagic cystitis"]
[]
[]
["ALMS1P","ALMS1P1 (ALMS1, Centrosome And Basal Body Associated Protein Pseudogene 1) ","Pseudogene","N-acetylornithine","Diseases associated with ALMS1P1 include Alstrom syndrome "]
["RAB3GAP1","RAB3GAP1 (RAB3 GTPase Activating Protein Catalytic Subunit 1) ","GTPase activator activity and Rab guanyl-nucleotide exchange factor activity. Related pathways are vesicle-mediated transport and COPI (coat protein complex I)-independent Golgi-to-ER retrograde traffic. Involved in regulated exocytosis of neurotransmitters and hormones. RAB3GAP, is involved in regulation of RAB3 activity and converts active RAB3-GTP to the inactive form ","1,5 –anhydroglucitol (1,5-AG)","Associated diseases include Warburg Micro syndrome 1 and Martsolf syndrome"]
["GCKR","GCKR (Glucokinase Regulator) ","Metabolism and transport of the SLBP (stem-loop binding protein) independent mature mRNA. ","Glucose/mannose","Diseases associated with GCKR include maturity-onset diabetes of the young and transient cerebral ischemia. A common GCKR variant (P446L; rs1260326; 600842.0001) is associated with triglyceride and fasting plasma glucose levels in the general population"]
[null,null,"GCKR is highly expressed relative to GCK in human liver and has very low expression in human pancreatic islets relative to GCK. Altered GCK regulation in liver may promote hepatic glucose metabolism and elevation of concentrations of malonyl-CoA (a substrate for de novo lipogenesis), raise of triglycerides and reduction of glucose levels "]
["CPS1","CPS1 (Carbamoyl-Phosphate Synthase 1) ","Involved in calcium ion binding and phospholipid binding. Related pathways are arginine metabolism and biosynthesis. Rate-limiting enzyme that catalyzes the first step of the hepatic urea cycle by synthesizing carbamoyl phosphate from ammonia, bicarbonate, and two molecules of ATP. Mitochondrial isozyme = CPS I; cytoplasmic enzyme = CPS II. CPS I catalyzes the conversion of ammonia and bicarbonate to carbamyl phosphate by utilizing N-acetylglutamate as a cofactor. ","Glycine","Associated diseases include carbamoylphosphate synthetase I deficiency and a neonatal form of pulmonary hypertension"]
["ETV5","ETV5 (ETS Variant 5). ","Transcription factor, sequence-specific DNA binding (containing the consensus nucleotide core sequence 5'-GGAA-3'). Related pathways are transcriptional misregulation in cancer and IL12-mediated signaling events. ","eGFRcrea","Diseases associated with ETV5 include Sertoli Cell-Only syndrome. Its orthologue has been linked to both obesity and bipolar disorder5"]
["HMGCR","HMGCR (3-Hydroxy-3-Methylglutaryl-CoA Reductase).","Involved in statin pathway, catalyzing a rate-limiting step in cholesterol biosynthesis. Participates also in the production of a wide variety of other compounds and plays a role in integrated breast cancer pathways. A cholesterol-independent role for the enzyme is suggested: Regulation of primordial germ cell migration. Sterol-induced binding of its sterol-sensing domain to the endoplasmic reticulum (ER) protein INSIG1 leads to accelerated degradation that could be blocked by proteasome inhibitors","LDLc","Diseases associated with HMGCR include Marek disease and hyperlipidemia, familial combined."]
["SLC16A10","SLC16A10 (Solute Carrier Family 16 Member 10) ","Plasma membrane amino acid transporter mediating transport of aromatic amino acids (Na(+)-independent transport of tryptophan, tyrosine, phenylalanine, and L-DOPA) across the plasma membrane. Involved in transport of sugars (incl. glucose), metal ions, bile salts, organic acids, amine compounds. Part of thyroid hormone signaling pathway.","Tyrosin","TAT1 (Slc16a10) defective mice (tat1−/−) grow and reproduce normally and show no gross phenotype. They show increased plasma, muscle and kidney aromatic amino acid concentrations under both normal and high protein diet6."]
["ZNF204P","ZNF204P (Zinc Finger Protein 204, Pseudogene) ","Pseudogene","eGFRcrea"]
["SLC17A1","SLC17A1 (Solute Carrier Family 17 Member 1). ","Symporter activity and phosphate ion transmembrane transporter activity. Part of the uricosurics pathway located in the proximal convoluted renal tubule essential for phosphate homeostasis. Involved in transport of sugars (incl. glucose), metal ions, bile salts, organic acids, and amine compounds","4-androsten-3beta, dehydroisoandrosterone sulfate (DHEA-S)","Associated diseases include gout and hyperuricemia."]
["LOC157273","LOC157273 (Uncharacterized) ","RNA gene affiliated with the non-coding-RNA class","m-HDL-FC (free cholesterol)"]
["TBC1D13","TBC1D13 (TBC1 Domain Family Member 13) ","GTPase activator activity and involved in vesicle-mediated transport. Seems to inhibit insulin-stimulated Glut4 translocation to the plasma membrane in mouse adipocytes. Interacts with constitutively active Rab1 and Rab10 (Rab GTPases); did not function as a GTPase-activating protein GAP for these GTPases","Indoleacetate"]
["C10orf32, C10orf32-ASMT","Official name: BORCS7-ASMT No gene product: Locus represents naturally occurring read-through transcription between the neighboring C10orf32 (chromosome 10 open reading frame 32) and AS3MT (arsenic, +3 oxidation state, methyltransferase) genes","The transcript is a candidate for nonsense-mediated mRNA decay (NMD), unlikely to produce a protein product.","DMA% (Dimethylarsinic acid %)"]
["NADSYN1","Nicotinamide adenine dinucleotide (NAD) synthetase ","NAD synthetase can use both glutamine and ammonia as amide donors and catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide. The product NAD functions as coenzyme in many metabolic redox reactions. It is also a precursor for several cell signaling molecules, and serves as a substrate for protein posttranslational modification reactions.","Vitamin D insufficiency"]
["SH2B3","SH2B3 (SH2B Adaptor Protein 3); also named lymphocyte adaptor protein (LNK)","Overall function includes signal transduction and phosphate ion binding. Pathways in which SH2B3 is involved are erythropoiesis with the erythropoietin-induced Jak-STAT pathway as well as megakaryocyte development and platelet production. SH2B3 controls hematopoietic stem cell (HSC) quiescence and self-renewal. SH2B3 is highly expressed in multipotent cells in bone marrow, lymph nodes, but also non-hemopoietic tissues such as testis, brain, and muscle.","Kinurenine","Associated diseases include thrombocythemia 1 and myelo-fibrosis with myeloid metaplasia. Somatic mutations in the SH2B3 gene were associated with isolated erythrocytosis."]
["UNC119B","Uncoordinated (Unc)-119 Lipid Binding Chaperone B ","Lipid binding and involvement in coordination of the trafficking of myristoylated proteins. Related pathways are organelle biogenesis, maintenance and cargo trafficking ","Butyrylcarnitine"]
["ACADS","ACADS (Acyl-CoA Dehydrogenase, C-2 To C-3 Short Chain) ","ACADS (mainly expressed in fat tissue, small intestine, and liver, but also brain regions as e.g. hippocampus); it is a key enzyme of a metabolic pathway involving fatty acid beta-oxidation and regulation of theta oscillations during sleep. In mice a deficiency in short-chain acyl-CoA dehydrogenase caused a marked slowing in the theta frequency during paradoxical sleep. ACADS interacts also with glyoxalase-1, a gene involved in the detoxification of metabolic by-products ","C3/C4 ratio","Associated diseases include short chain acyl CoA dehydrogenase deficiency (SCADD) a rare disorder of fatty acid catabolism (fatty acid oxidation disorder) and ethylmalonic encephalopathy."]
["LOC105370690","Uncharacterized LOC105370690","LOC105370690 is an RNA gene affiliated with the non-coding RNA class","Asparagine"]
["PDILT","PDILT (Protein Disulfide Isomerase Like, Testis Expressed)","Protein disulfide isomerase (PDI) and peptidyl-proline 4-dioxygenase activity. PDIs are endoplasmic reticulum (ER) proteins, catalyzing protein folding and interchange of thiol-disulfide reactions, i.e.  reaction of a thiol (RSH) with a disulfide (R'SSR') to form a new disulfide (RSSR') and a thiol (R'SH) with substituent exchange. PDILT functions probably as a chaperone and has no oxidoreductase activity in vitro. This gene's expression seems to be limited to the testis. ","Urinary uromodulin levels"]
["PDXDC1","PDXDC1 (Pyridoxal Dependent Decarboxylase Domain Containing 1) ","Pyridoxal phosphate (active form of vitamin B6) binding and carboxylyase activity. Cadherin binding and therewith involved in cell-cell adhesion. Expression in all human tissues examined thus far. Northern blot analysis detected PDXDC1 expression in all human tissues and cell lines examined","Phosphatidycholin aa C38:2 (Glycerophospho-lipid levels)"]
["NTAN1","NTAN1 (N-Terminal Asparagine Amidase) ","Protein-N-terminal asparagine, but not N-terminal glutamine amidohydrolase activity. Converting asparagine to aspartate by enzymatic deamidation. Required for the ubiquitin-dependent turnover of intracellular proteins. By enzymatic deamidation, NTAN1 converts the tertiary destabilizing N-terminal residue asparagine to the secondary destabilizing residue aspartate.","Linoleic acid/PUFA","Associated diseases include tendinitis"]
["SLC7A6","SLC7A6 (Solute Carrier Family 7 Member 6). ","SLC7A6 is an organic solute transmembrane transporter protein expressed in all tissues tested except liver. Functional annotations encompass transport of glucose and other sugars, bile salts and organic acids, metal ions, amine compounds and L-amino acids. ","Lysine/glutaroyl carnitine","Associated diseases are lysinuric protein intolerance"]
["FBXL20","F-Box and Leucine-rich repeat protein 20 ","F-box proteins modulate inflammation and innate immunity. Related pathways for FBXL20 are immune system and class I MHC mediated antigen processing and presentation. Part of the substrate-recognition components of ubiquitin ligase complexes.","Glomerular filtration rate (creatinine)","Association with a variety of neurodegenerative diseases. Abnormal expression of FBXL20 is hypothesized to play a role in the development of epilepsy7. A defect in SCRAPPER (F-box protein subunit of SCF type E3 ubiquitin ligase) coded by FBXL20 could lead to neurodegenerative phenotypes. Heterozygous Scrapper knockout [SCR (+/-)] mice showed behavioral phenotypes suggesting that molecular degradation conferred by SCRAPPER might play a role in fear memory formation"]
["CDK12","CDK12 (Cyclin Dependent Kinase 12). Protein tyrosine kinase activity","CDKs transfer phosphorus-containing groups and play regulatory roles in e.g. cell-cycle progression, transcription and translation. CDK12 seems involved in gene expression and formation of HIV elongation complex in the absence of HIV Tat. Might also be involved in regulation of MAP kinase activity, estrogen signaling, and processes related to DNA replication, recombination, and repair. The CYCK-CDK12 complex has a role in maintenance of genomic stability by regulating the expression of DNA damage response genes","Urinary histidine/τ-methylhistidine","Involved in many pathological processes. CDK12 inhibitors are considered as anti-cancer agents8"]
["ELL","ELL (Elongation Factor For RNA Polymerase II)","Increases the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Related pathways are HIV life-cycle and transcription-coupled nucleotide excision repair and oncogenesis","Myo-inositol","Associated diseases include acute myeloid leukemia"]
["BCL3","BCL3 (B-Cell CLL/Lymphoma 3) ","Part of the regulation of transcriptional activation of NF-kappa-B target genes. Inhibits the nuclear translocation of the NF-kappa-B p50 subunit (cytoplasm) and functions as transcriptional activator of NF-kappa-B target genes (nucleus). It is hypothesized that BCL3 is inducible by immunologic adjuvants and confers a survival advantage to T cells both in vivo and in vitro. Constitutive BCL3 phosphorylation by GSK3 regulates BCL3 turnover and transcriptional activity. BCL3 seems inducible by DNA damage. BCL3 is as an essential negative regulator of Toll-like receptor (TLR) signaling. Bcl3-deficient mice and cells were found to be hypersensitive to TLR activation and unable to control responses to lipopolysaccharides. Other related pathways are cytokine receptor signaling pathways and TNF signaling pathways","LDLc fasting","Associated diseases are lymphoma and chronic lymphocytic leukemia."]
[]
["APOE","APOE (Apolipoprotein E) ","Involved in metabolism of fat-soluble vitamins and statin pathway. Essential for the catabolism of triglyceride-rich lipoprotein constituents; mediates binding, internalization, and catabolism. Major apoprotein of the chylomicron; can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.","L-LDL-FC","Diseases associated with APOE include lipoprotein glomerulopathy and sea-blue histiocyte disease. Mutations in APOE result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III) resulting in increased plasma cholesterol and triglycerides as a consequence of impaired clearance of chylomicron and VLDL remnants. The APOE*4 allele is genetically associated with the common late onset familial and sporadic forms of Alzheimer disease (AD) and gene dose is a major risk factor. Risk for AD increased from 20% to 90% and mean age at onset decreased from about 84 to 68 years with increasing number of APOE*4 alleles. Homozygosity for APOE*4 seems sufficient to cause AD by age 80. The pathogenetic mechanism is not known."]
["APOC1","APOC1 (Apolipoprotein C1)","Member of the apolipoprotein C1 family expressed primarily in the liver and activated upon differentiation of monocytes into macrophages. Central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. Interferes directly with fatty acid uptake, inhibits cholesteryl ester transfer protein (CETP) in plasma and lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein. Associates with HDL and triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Also involved in statin pathway.","LDL-C","Associated diseases include adermatoglyphia"]
["RASIP1","RASIP1 (Ras Interacting Protein 1)","Involved in formation of vascular structures that develop via both vasculogenesis and angiogenesis. Critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion. Essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Assumed to function as negative regulator of amino acid starvation-induced autophagy. RASIP1 exhibits a higher affinity for Ras-GTP than Ras-GDP. Usually Ras effectors localize to the plasma membrane, but RASIP1 localizes to perinuclear, juxta-Golgi vesicles in intact cells and is recruited to Golgi membranes by activated Ras.","FUT2 - Fucose","Seems to be associated with risk for T1DM9 and ischemic stroke10"]
["A Information was retrieved from GeneCards (www.genecards.org)1; OMIM® - Online Mendelian Inheritance in Man® (www.omim.org)2; Entrez Gene (www.ncbi.nlm.nih.gov/gene)3; and UniProt: the Universal Protein Resource (www.uniprot.org)4, or otherwise as cited"]
["B Metabolite (ratio) with lowest p-value in GWAS"]
[]
["References\n1. Safran, M. et al. GeneCards Version 3: the human gene integrator. Database (Oxford) 2010, baq020 (2010).\n2. Amberger, J.S., Bocchini, C.A., Schiettecatte, F., Scott, A.F. & Hamosh, A. OMIM.org: Online Mendelian Inheritance in Man (OMIM(R)), an online catalog of human genes and genetic disorders. Nucleic Acids Res 43, D789-98 (2015).\n3. Maglott, D., Ostell, J., Pruitt, K.D. & Tatusova, T. Entrez Gene: gene-centered information at NCBI. Nucleic Acids Res 39, D52-7 (2011).\n4. The UniProt, C. UniProt: the universal protein knowledgebase. Nucleic Acids Res 45, D158-D169 (2017).\n5. Williams, M.J. et al. The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder. PLoS Genet 12, e1006104 (2016).\n6. Mariotta, L. et al. T-type amino acid transporter TAT1 (Slc16a10) is essential for extracellular aromatic amino acid homeostasis control. J Physiol 590, 6413-24 (2012).\n7. Fu, P. et al. Abnormal Expression of FBXL20 in Refractory Epilepsy Patients and a Pilocarpine-Induced Rat Model. Neurochem Res 41, 3020-3031 (2016).\n8. Zhang, T. et al. Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. Nat Chem Biol 12, 876-84 (2016).\n9. Qiu, Y.H., Deng, F.Y., Li, M.J. & Lei, S.F. Identification of novel risk genes associated with type 1 diabetes mellitus using a genome-wide gene-based association analysis. J Diabetes Investig 5, 649-56 (2014).\n10. Cotlarciuc, I. et al. Effect of genetic variants associated with plasma homocysteine levels on stroke risk. Stroke 45, 1920-4 (2014).\n\n"]

{"sheet":"Associations p<0.05","index":4,"n_rows":406,"n_cols":27,"rows_kept":406,"cut":false,"hidden":false,"merged":[[1,5,2,5],[1,0,2,0],[1,1,2,1],[1,2,2,2],[1,3,2,3],[1,4,2,4],[1,25,2,25],[1,26,2,26],[1,6,2,6],[1,7,2,7],[1,8,2,8],[1,9,2,9],[1,10,1,23],[1,24,2,24]]}
["Supplemental Tab 4: Associations (p < 0.05) of human metabolism SNPs with BMI, mental disorders, and related quantitative phenotypes"]
["Region 1Mb ","SNP","CHR","Chr region (cytogenetic bands)","Position","Mapped Gene","Effect allele (metabolite)","Metabolite/marker/trait  (Source: GWAS Catalog)","Metabolite/marker/trait  (Source: paper)","p-value of metabolite","p-value ",{"$nulls":13},"Effect directions/info proxy-SNP","First Autor","Pubmed ID"]
[{"$nulls":10},"BMI","Education attaintment","Neuroticism","Alzheimer's desease","Schizophrenia","Wellbeing","Aggressive behavior","Anxiety ","Depressive symptoms","MDD","Bipolar disorder","Autism spectrum disorder","Internalizing problems","ADHD"]
[1,"rs12085006",1,"1p36.22",11898666,"LOC390997 - LOC105376742"," ","Folate pathway vitamin levels",null,null," "," "," ",null," "," ",null," "," "," ",null," ",null,1.7819999999999999E-2,"proxy rs1999594","Hazra A","19744961"]
[2,"rs1800615",1,"1p36.21","15505786","CASP9"," ","Glomerular filtration rate (creatinine)",null,null,1.5310000000000001E-2," "," ",null," "," ",null," "," "," ",null," ",null," ",null,"Pattaro C","26831199"]
[2,"rs12124078",1,"1p36.21","15543404","DNAJC16"," ","Glomerular filtration rate in non diabetics (creatinine)",null,null,1.5310000000000001E-2," "," ",null," "," ",null," "," "," ",null," ",null," ",null,"Pattaro C","26831199"]
[3,"rs1697421",1,"1p36.12","21496799","NBPF3 - ALPL"," ","Blood metabolite ratios",null,"3,00E-014"," "," "," ",1.4999999999999999E-2," "," ",null," "," "," ",null," ",null,3.3849999999999998E-2,null,"Shin SY","24816252"]
[4,"rs1053941",1,"1p34.1","45618711","NASP"," ","Blood metabolite levels",null,null," ",1.7299999999999999E-2,1.176E-2,null," "," ",null," "," "," ",null," ",4.2000000000000003E-2," ",null,"Shin SY","24816252"]
[5,"rs7542172",1,"1p33","46525009","DMBX1 - LOC105378696"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null,9.0779999999999993E-3," "," ",null," ",null," ",null,"Shin SY","24816252"]
[5,"rs6678639",1,"1p33","46866294","CYP4Z2P"," ","Blood metabolite ratios",null,null," "," "," ",null," "," ",null," ",1.6029999999999999E-2," ",null," ",null," ",null,"Shin SY","24816252"]
[5,"rs6663731",1,"1p33","46881755","CYP4Z2P"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null," ",1.515E-2," ",null," ",null," ",null,"Shin SY","24816252"]
[5,"rs9333029",1,"1p33","46930490","CYP4A11"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null," ",1.163E-2," ",null," ",null," ",null,"Shin SY","24816252"]
[5,"rs9332998",1,"1p33","46938514","CYP4A11"," ","Metabolic traits",null,null," "," "," ",null," "," ",null," ",1.6490000000000001E-2," ",null," ",null," ",null,"Suhre K","21886157"]
[6,"rs13375749",1,"1p32.3","53230210","MAGOH"," ","Blood metabolite levels",null,"3,00E-028"," "," "," ",null," "," ",null," ",2.5469999999999998E-3," ",null," ",3.9E-2," ",null,"Shin SY","24816252"]
[8,"rs72669744",1,"1p32.2","55650832","MIR4422 - LOC105378740",null,"Lipid metabolism phenotypes",null,null,4.3249999999999997E-2,{"$nulls":13},"proxy rs17112601","Kettunen J","22286219"]
[9,"rs10889332",1,"1p31.3",62485187,"DOCK7",null,"Metabolite levels",null,8.0000000000000006E-15,null,null,null,3.95E-2,{"$nulls":11},"Inouye M",22916037]
[9,"rs1168029",1,"1p31.3","62503731","DOCK7",null,"Lipid metabolism phenotypes",null,2.9999999999999998E-13,null,null,null,4.8000000000000001E-2,{"$nulls":11},"Kettunen J",22286219]
[9,"rs6679002",1,"1p31.3",62734265,"DOCK7 - ATG4C","G","Blood metabolite levels",null,"2,00E-015",null,null,null,2.8570000000000002E-2,{"$nulls":11},"Shin SY",24816252]
[10,"rs211718",1,"1p31.1",75640990,"SLC44A5","C","Metabolite levels",null,"1,00E-063",{"$nulls":10},1.38E-2,{"$nulls":4},"Illig T",20037589]
[10,"rs211718",1,"1p31.1",75640990,"SLC44A5","C","Metabolic traits",null,"2,00E-071",{"$nulls":10},1.38E-2,{"$nulls":4},"Suhre K",21886157]
[10,"rs7552404",1,"1p31.1",75670261,"SLC44A5","A","Blood metabolite levels","decanoylcarnitine","3,00E-043",{"$nulls":10},6.5120000000000004E-3,{"$nulls":4},"Shin SY",24816252]
[10,"rs7552404",1,"1p31.1",75670261,"SLC44A5","A","Acylcarnitine levels",null,"2,00E-049",{"$nulls":10},6.5120000000000004E-3,{"$nulls":4},"Draisma HH","26068415"]
[10,"rs4949874",1,"1p31.1",75696204,"SLC44A5","C","Blood metabolite ratios",null,"2,00E-172",{"$nulls":10},1.2070000000000001E-2,{"$nulls":4},"Shin SY",24816252]
[10,"rs11161521",1,"1p31.1",75750645,"ACADM","C","Blood metabolite levels",null,"1,00E-063",{"$nulls":10},1.2460000000000001E-2,{"$nulls":4},"Shin SY",24816252]
[11,"rs599839",1,"1p13.3","109279544","CELSR2 - PSRC1"," ","Metabolite levels",null,null,4.2509999999999999E-2," "," ",null," "," ",null," "," "," ",null," ",null," ",null,"KIM, YJ","21909109"]
[11,"rs12136063",1,"1p13.3","109471548","SYPL2"," ","Glomerular filtration rate (creatinine)",null,"5,00E-008",1.5310000000000001E-2,1.7909999999999999E-4," ",null," "," ",null," "," "," ",1.8319999999999999E-2,8.4790000000000004E-3,null," ",null,"Pattaro C","26831199"]
[11,"rs1466788",1,"1p13.3","110076108","ALX3 - LINC01397"," ","Blood metabolite levels",null,null," ",6.4050000000000001E-4," ",null,5.7629999999999999E-3,1.15E-3,null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[13,"rs1163251",1,"1p12",119667132,"ZNF697 - LOC105378937","C","Blood metabolite levels",null,"7,00E-027",{"$nulls":10},4.8510000000000003E-3,{"$nulls":4},"Shin SY",24816252]
[13,"rs478093",1,"1p12","119712503","PHGDH"," ","Metabolite levels",null,null," "," "," ",null," "," ",null,1.9400000000000001E-3," "," ",null," ",null," ",null,"Xie W","23378610"]
[13,"rs477992",1,"1p12","119714953","PHGDH"," ","Metabolic traits",null,null," "," "," ",null," "," ",null,5.293E-3," "," ",null," ",null," ",null,"Suhre K","21886157"]
[15,"rs267734",1,"1q21.3","150979001","CERS2 - LOC105371438"," ","Glomerular filtration rate (creatinine)",null,null," "," ",0.01,null,5.3610000000000003E-3," ",null," "," "," ",null," ",null," ",null,"Pattaro C, Köttgen A","20383146, 2683119"]
[15,"rs267734",1,"1q21.3",150979001,"CERS2 - LOC105371438","T","Glomerular filtration rate in non diabetics (creatinine)",null,"3,00E-012",{"$nulls":6},3.9980000000000002E-2,{"$nulls":8},"Pattaro C",26831199]
[15,"rs267734",1,"1q21.3",150979001,"CERS2 - LOC105371438","T","Chronic kidney disease","Chronic kidney disease","1,00E-012",{"$nulls":6},3.9980000000000002E-2,{"$nulls":8},"Köttgen A",20383146]
[15,"rs267734",1,"1q21.3",150979001,"CERS2 - LOC105371438","T","Glomerular filtration rate (creatinine)","Glomerular filtration rate (creatinine)","4,00E-013",{"$nulls":6},3.9980000000000002E-2,{"$nulls":8},"Pattaro C",26831199]
[15,"rs12566232",1,"1q21.3","151867362","THEM5 - THEM4"," ","Blood metabolite levels",null,null," "," ",1.8579999999999999E-2,null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[15,"rs6685187",1,"1q21.3","151886412","THEM4"," "," ",null,null," "," ",1.3789999999999999E-4,null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[15,"rs10788817",1,"1q21.3","151910380","THEM4 - KRT8P28"," ","Serum metabolite levels",null,null," "," ",3.4729999999999999E-4,null," ",4.0899999999999999E-2,null," "," "," ",null," ",null," ",null,"YU,B","24625756"]
[15,"rs10494270",1,"1q21.3","151934697","THEM4 - KRT8P28"," ","Acylcarnitine levels",null,null," "," ",2.1989999999999999E-2,null," "," ",null," "," "," ",null," ",null," ",null,"Draisma HH","26068415"]
[15,"rs6693388",1,"1q21.3","151958169","KRT8P28 - S100A10"," ","Blood metabolite ratios",null,null," "," ",2.9219999999999999E-2,null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[20,"rs2802729",1,"1q43","243338461","SDCCAG8","A","Glomerular filtration rate (creatinin in serum)","eGFRcrea",2E-8," ",1.9E-3," ",null,6.0800000000000002E-6,2.8199999999999999E-2,1.8469999999999999E-3," "," "," ",3.2309999999999998E-2," ",null," ","A: eGFRcrea ↓; Schizo ↓","Pattaro C","26831199"]
[21,"rs807601",2,"2p24.3","15652890","DDX1 - LOC101926966"," ","Glomerular filtration rate (creatinin in serum)","eGFRcrea",null," "," "," ",null," "," ",null," "," "," ",null," ",null,9.8459999999999997E-4,null,"Pattaro C","26831199"]
[22,"rs6754295",2,"2p24.1","20983311","LOC101928271 - APOB"," ","Lipid metabolism phenotypes",null,null," ",2.4850000000000001E-2," ",null," "," ",null," ",1.0959999999999999E-2," ",null," ",null," ",null,"Chasman DI","19936222"]
[22,"rs676210",2,"2p24.1","21008652","APOB"," ","Lipid metabolism phenotypes",null,"9,00E-056"," ",4.3299999999999998E-2," ",5.3600000000000002E-3," "," ",null," ",3.8830000000000003E-2," ",null," ",null," ",null,"Chasman DI","19936222"]
[22,"rs673548",2,"2p24.1","21014672","APOB"," ","Lipid metabolism phenotypes",null,null," ",3.9489999999999997E-2," ",null," "," ",null," ",3.7019999999999997E-2,4.6339999999999999E-2,null," ",null," ",null,"Inouye M, Chasman DI","22916037, 19936222"]
[22,"rs673548",2,"2p24.1",21014672,"APOB","A","Metabolite levels",null,"1,00E-013",null,null,null,1.184E-2,{"$nulls":11},"Inouye M, Chasman DI","22916037, 19936222"]
[22,"rs673548",2,"2p24.1",21014672,"APOB","A","Lipid metabolism phenotypes",null,"5,00E-042",null,null,null,1.184E-2,{"$nulls":11},"Inouye M, Chasman DI","22916037, 19936222"]
[22,"rs1367117",2,"2p24.1","21041028","APOB"," ","Lipid metabolism phenotypes",null,null," ",3.0380000000000001E-2," ",null," "," ",null," "," "," ",null," ",null," ",null,"Chasman DI",19936222]
[22,"rs312985",2,"2p24.1",21155933,"TDRD15 - LOC105374317","A","Lipid metabolism phenotypes",null,"1,00E-017",{"$nulls":10},2.4199999999999999E-2,{"$nulls":4},"Chasman DI",19936222]
[22,"rs506585",2,"2p24.1",21174310,"TDRD15 - LOC105374317","A","Lipid metabolism phenotypes",null,"2,00E-022",{"$nulls":10},1.9689999999999999E-2,{"$nulls":4},"Chasman DI",19936222]
[23,"rs1395",2,"2p23.3","27201768","SLC5A6","A","Blood metabolite levels",null,"8,00E-011"," "," "," ",null," "," ",null," "," "," ",null,1.4489999999999999E-2,2.9340000000000001E-2," ",null,"Shin SY","24816252"]
[23,"rs1260326",2,"2p23.3","27508073","GCKR","A","Lipid metabolism phenotypes ","HDL total ",6.2999999999999994E-36,9.2E-5,{"$nulls":4},5.1599999999999997E-3,{"$nulls":4},2.3119999999999998E-3,null,null,null,"A: metab ↑;BMI ↓","Chasman DI",19936222]
[23,"rs1260326",2,"2p23.3","27508073","GCKR","?","Metabolite levels ","S-HDL-P",9.9999999999999998E-13,9.2E-5,{"$nulls":4},5.1599999999999997E-3,{"$nulls":4},2.3119999999999998E-3,null,null,null,"?","Inouye M",22916037]
[23,"rs1260326",2,"2p23.3","27508073","GCKR","C","Blood metabolite levels","Mannose",5.9999999999999998E-56,9.2E-5,{"$nulls":4},5.1599999999999997E-3,{"$nulls":4},2.3119999999999998E-3,null,null,null,"C: metab ↑; BMI ↑","Korostishevsky M",25898920]
[23,"rs1260326",2,"2p23.3","27508073","GCKR","T","Glomerular filtration rate (creatinin in serum)","eGFRcre",2.9999999999999998E-14,9.2E-5,{"$nulls":4},5.1599999999999997E-3,{"$nulls":4},2.3119999999999998E-3,null,null,null,"T: eGFRcrea ↑; BMI ↓","Köttgen A, Pattaro C","20383146, 2683119"]
[23,"rs1260326",2,"2p23.3","27508073","GCKR","T","Blood metabolite ratios","glucose/mannose",3E-148,9.2E-5," "," ",null," ",5.1599999999999997E-3,null," "," "," ",2.3119999999999998E-3," ",null," ","T: metab ↑; BMI ↓","Shin SY","24816252"]
[23,"rs780094",2,"2p23.3","27518370","GCKR","T","Metabolic traits","glucose/mannose",null,2.05E-4," "," ",null," ",3.7200000000000002E-3,2.7660000000000001E-2," "," "," ",1.354E-3," ",null," ",null,"Suhre K","21886157"]
[23,"rs780092",2,"2p23.3","27520287","GCKR"," ","Metabolite levels",null,null," "," "," ",null,2.0240000000000002E-3," ",null," "," "," ",null," ",null," ",null,"KIM, YJ","21909109"]
[24,"rs559555",2,"2p23.1",31585905,"SRD5A2","A","Blood metabolite levels",null,"7,00E-019",{"$nulls":6},4.1770000000000002E-2,{"$nulls":8},"Shin SY",24816252]
[24,"rs559555",2,"2p23.1",31585905,"SRD5A2","A","Blood metabolite ratios",null,"1,00E-044",{"$nulls":6},4.1770000000000002E-2,{"$nulls":8},"Shin SY",24816252]
[25,"rs4299376",2,"2p21","43845437","ABCG8"," ","Lipid metabolism phenotypes",null,null," "," "," ",null," ",1.585E-2,null," "," "," ",null," ",null," ",null,"Chasman DI","19936222"]
[26,"rs895636",2,"2p21","44961214","SIX3 - LOC101926949"," ","Metabolite levels",null,null," ",1.223E-2," ",null," "," ",null," "," "," ",null," ",null," ",null,"Kim YJ","21909109"]
[28,"rs9309413",2,"2p14","68343640","LOC102724389"," ","Metabolite levels",null,null," ",1.8489999999999999E-2," ",null," "," ",null," "," "," ",null," ",null," ",null,"Gieger C","19043545"]
[29,"rs6546838",2,"2p13.1","73452153","ALMS1","A","Glomerular filtration rate (creatinin in serum)","eGFRcrea",7.9999999999999996E-20," ",2.0999999999999999E-3," ",null,1.736E-6," ",null," "," "," ",null," ",null," ","A: eGFRcrea ↓; Schizo ↓","Pattaro C","26831199"]
[29,"rs9309473",2,"2p13.1","73516855","ALMS1","G","Metabolite levels","N-acetylated compound(s): X.NH.CO.CH3",4.0999999999999999E-19," ",2.3E-3," ",null,1.511E-6," ",null," "," "," ",null," ",null," ","G: metab ↑; Schizo ↑","Nicholson G",21931564]
[29,"rs11884776",2,"2p13.1","73519796","ALMS1","C","Urinary metabolites (H-NMR features)","N-acetylated compounds",6.0000000000000001E-17," ",1.8E-3," ",null,2.5730000000000002E-6," ",null," "," "," ",null," ",null," ","C: metab ↑; Schizo ↓","Rueedi R","24586186"]
[29,"rs10469966",2,"2p13.1","73525241","ALMS1","A","Blood metabolite levels","X-12093",1E-51," ",9.3999999999999997E-4," ",null,4.4369999999999998E-7," ",null," "," "," ",null," ",null," ","A: metab ↑; Schizo ↑","Shin SY","24816252"]
[29,"rs6546847",2,"2p13.1","73558231","ALMS1","A","Urinary metabolites (H-NMR features)","N-acetylated compounds",5.3000000000000003E-161," ",4.4999999999999997E-3," ",null,2.587E-6," ",null," "," "," ",null," ",null," ","A: metab ↑; Schizo ↓","Rueedi R","24586186"]
[29,"rs13391552",2,"2p13.1","73591809","ALMS1","A","Metabolic traits","N-acetylornithine ",5.0000000000000001E-252," ",1.5E-3," ",null,3.3780000000000001E-6," ",null," "," "," ",null," ",null," ","A: metab ↓; Schizo ↑","Suhre K","21886157"]
[29,"rs6546857",2,"2p13.1","73610828","ALMS1 - NAT8","A","Metabolite levels  (X-11787)","X-11787",9.9999999999999996E-24," ",1.9E-3," ",null,6.8039999999999998E-7," ",null," "," "," ",null," ",null," ","A: metab ↑; Schizo ↓","YU B","23934736"]
[29,"rs10178409",2,"2p13.1","73628380","ALMS1 - NAT8","T","Urinary metabolites","N-acetylaspartate ",9.9999999999999999E-96," ",6.9899999999999997E-3," ",null,2.298E-5," ",null," "," "," ",null," ",null," ","T: metab ↑; Schizo ↑","Raffler J","26352407"]
[29,"rs13538",2,"2p13.1","73641201","NAT8","A","Blood metabolite ratios","N-acetylornithine/ myo-inositol",7.9999999999999995E-157," ",6.1000000000000004E-3," ",null,1.8090000000000001E-5," ",null," "," "," ",null," ",null," ","A: metab ↑; Schizo ↓","Shin SY","24816252"]
[29,"rs13538",2,"2p13.1","73641201","NAT8","G","Glomerular filtration rate (creatinin in serum)","eGFRcre",5.0000000000000002E-14,null,6.1000000000000004E-3,null,null,1.8090000000000001E-5,{"$nulls":9},"G: eGFRcrea ↑; Schizo ↑","Köttgen A",20383146]
[29,"rs13538",2,"2p13.1","73641201","NAT8","A","Metabolite levels  (X-11787)","X-11787",1.9999999999999999E-23,null,6.1000000000000004E-3,null,null,1.8090000000000001E-5,{"$nulls":9},"A: metab ↑; Schizo ↓","YU B"]
[29,"rs10206899",2,"2p13.1","73673773","ALMS1P","T","Blood metabolite levels","N-Acetylornitihine ",2E-14," ",9.4000000000000004E-3," ",null,1.9199999999999999E-5," ",null," "," "," ",null," ",null," ","T: metab ↑; Schizo ↓","Shin SY","20383145"]
[30,"rs6430553",2,"2q21.3","134873830","CCNT2-AS1, ACMSD","T","Blood metabolite levels",null,"6,00E-012",3.4450000000000001E-3," ",9.4510000000000004E-4,2.1860000000000001E-2,1.3090000000000001E-3," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[30,"rs7570971",2,"2q21.3","135080336","RAB3GAP1","A","Carbohydrates","1,5-anhydroglucitol (1,5-AG)",7.9999999999999999E-45,1.5120000000000001E-6," "," ",null," "," ",null," "," "," ",1.975E-2," ",null," ","A: metab ↓; BMI ↓","Shin SY","24816252"]
[31,"rs560887",2,"2q31.1","168906638","G6PC2"," ","Metabolite levels",null,null," "," "," ",null," "," ",null," "," "," ",null,4.1799999999999997E-2,null," ",null,"Inouye M","22916037"]
[31,"rs16856247",2,"2q31.1",168927903,"ABCB11","T","Metabolite levels",null,"2,00E-015",{"$nulls":12},1.3809999999999999E-2,null,null,"Kim YJ",21909109]
[31,"rs4667594",2,"2q31.1",169151996,"LRP2","A","Glomerular filtration rate (creatinin in serum)","Glomerular filtration rate (creatinin in serum)","4,00E-008",{"$nulls":6},1.18E-2,null,null,null,2.648E-2,{"$nulls":4},"Pattaro C",26831199]
[33,"rs3738934",2,"2q34","210009522","RPE","C","Blood metabolite levels",null,"1,00E-134"," "," "," ",1.5480000000000001E-2," "," ",null," "," "," ",null," ",null,3.4779999999999998E-2,null,"Shin SY",24816252]
[33,"rs2286963",2,"2q34","210195326","ACADL"," ","Acylcarnitine levels","Metabolite levels, Acylcarnitin","3E-60, 3E-118"," "," "," ",1.196E-2," "," ",4.5440000000000001E-2," ",4.2689999999999999E-2," ",null," ",null," ",null,"Illig T, Draisma HH","20037589, 26068415"]
[33,"rs3764913",2,"2q34","210210185","ACADL"," ","Metabolite levels",null,"4,00E-029"," "," "," ",1.108E-2," "," ",3.6560000000000002E-2," ",2.5600000000000001E-2," ",null," ",null," ",null,"Hong MG","23281178"]
[33,"rs1509569",2,"2q34","210267691","ACADL_-_MYL1"," ","Urinary metabolites (H-NMR_features)",null,"3,00E-018"," "," "," ",3.4139999999999997E-2," "," ",null," ",2.9409999999999999E-2," ",null," ",null," ",null,"Rueedi R","24586186"]
[33,"rs1047891",2,"2q34","210675783","CPS1","A","Plasma homocysteine levels (post-methionine load test)","Plasma homocysteine levels",9E-13,8.14E-5," "," ",null," "," ",null," "," "," ",null," ",null," ","A: metab ↑; BMI↑","William SR","24651765"]
[33,"rs715",2,"2q34","210678331",null,"T","Amino acid levels","Ser",3E-11,7.1300000000000003E-6,{"$nulls":13},"T: metab ↓; BMI ↓","Draisma HH",26068415]
[33,"rs715",2,"2q34",210678331,"CPS1","T","Metabolite levels","Glycine",2.9999999999999999E-50,7.1300000000000003E-6," "," ",null," "," ",null," "," "," ",null," ",null," ","T: glycine ↓; BMI ↓","Shin SY, Xie W, Raffler J","24816252, 23378610, 26352407"]
[33,"rs16844839",2,"2q34","210716521","CPS1 - LOC107985978"," ","Amino acid levels",null,null,2.1849999999999999E-3," "," ",null," "," ",null," "," "," ",null," ",null," ",null,"Draisma HH","26068415"]
[33,"rs2216405",2,"2q34","210752170","CPS1 - LOC107985978"," ","Metabolism Glycine/PCaeC38:2",null,null,2.0470000000000002E-3," "," ",null," "," ",null," ",3.9600000000000003E-2," ",3.0710000000000001E-2," ",null," ",null,"Illig, T, Suhre K","20037589, 21886157"]
[35,"rs2712184",2,"2q35",216818056,"LOC101928278","A","Glomerular filtration rate in non diabetics (creatinine)","Glomerular filtration rate in non diabetics (creatinine)","1,00E-010",{"$nulls":10},4.5920000000000002E-2,{"$nulls":4},"Pattaro C",26831199]
[36,"rs887829",2,"2q37.1",233759924,"UGT1A9, UGT1A, UGT1A6, UGT1A7, UGT1A4, UGT1A5, UGT1A10, UGT1A3, UGT1A8","C","Serum metabolite levels",null,"8,00E-023",{"$nulls":10},5.0289999999999996E-3,{"$nulls":4},"Yu B",24625756]
[36,"rs887829",2,"2q37.1",233759924,"UGT1A9, UGT1A, UGT1A6, UGT1A7, UGT1A4, UGT1A5, UGT1A10, UGT1A3, UGT1A8","C","Metabolite levels",null,"9,00E-025",{"$nulls":10},5.0289999999999996E-3,{"$nulls":4},"Hong MG",23281178]
[36,"rs887829",2,"2q37.1",233759924,"UGT1A9, UGT1A, UGT1A6, UGT1A7, UGT1A4, UGT1A5, UGT1A10, UGT1A3, UGT1A8","C","Blood metabolite levels",null,"2,00E-056",{"$nulls":10},5.0289999999999996E-3,{"$nulls":4},"Shin SY",24816252]
[36,"rs887829",2,"2q37.1",233759924,"UGT1A9, UGT1A, UGT1A6, UGT1A7, UGT1A4, UGT1A5, UGT1A10, UGT1A3, UGT1A8","C","Metabolic traits",null,"3,00E-074",{"$nulls":10},5.0289999999999996E-3,{"$nulls":4},"Suhre K",21886157]
[36,"rs4148324",2,"2q37.1",233764076,"UGT1A6, UGT1A1, UGT1A5, UGT1A8, UGT1A, UGT1A4, UGT1A3, UGT1A9, UGT1A10","G","Blood metabolite levels",null,"2,00E-116",{"$nulls":10},4.1549999999999998E-3,{"$nulls":4},"Shin SY",24816252]
[39,"rs6804368",3,"3p24.1","30712081","TGFBR2 - GADL1"," ","Blood metabolite levels",null,null," "," "," ",null," ",2.8259999999999998E-4,null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[41,"rs17279437",3,"3p21.31","45772602","SLC6A20"," ","Blood metabolite ratios",null,null," "," "," ",null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[42,"rs4687717",3,"3p21.1","53248172","TKT"," ","Blood metabolite ratios",null,null," "," "," ",null,3.8809999999999999E-3," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[43,"rs13069049",3,"3p14.1","66759518","LOC105377143 - LOC105377144"," ","Metabolite levels",null,null," ",4.9919999999999999E-2," ",null," "," ",null," "," "," ",null," ",null," ",null,"Kim YJ","21909109"]
[44,"rs17806888",3,"3p14.1","67365898","SUCLG2"," ","Blood metabolite levels",null,null,5.0540000000000003E-3,3.5400000000000001E-2," ",null," "," ",null,5.7000000000000002E-3," "," ",null," ",null," ",null,"Shin SY","24816252"]
[46,"rs2861422",3,"3q23","142005802","TFDP2"," ","Glomerular filtration rate (creatinin in serum)",null,null," ",2.2499999999999999E-2," ",null," "," ",null," "," "," ",null,1.1270000000000001E-2,null," ",null,"Pattaro C","26831199"]
[46,"rs347685",3,"3q23","142088295","TFDP2"," ","Glomerular filtration rate in non diabetics (creatinine)",null,null," ",6.9629999999999996E-3," ",null," "," ",null," "," "," ",null,6.2919999999999998E-3,null," ",null,"Pattaro C","26831199"]
[47,"rs9682041",3,"3q26.2","170374114","SKIL"," ","Glomerular filtration rate in non diabetics (creatinine)",null,null," "," ",3.3489999999999999E-2,null," ",2.6259999999999999E-2,null," ",6.2960000000000004E-3," ",null," ",null," ",null,"Pattaro C","26831199"]
[48,"rs9842133",3,"3q26.33",179946314,"PEX5L","C","Blood metabolite levels",null,"4,00E-012",{"$nulls":6},1.6980000000000001E-3,null,null,null,3.4090000000000001E-3,{"$nulls":4},"Shin SY ",24816252]
[49,"rs2270968",3,"3q27.1","183037421","MCCC1"," ","Blood metabolite levels",null,null," "," "," ",null," ",1.729E-2,null," ",4.7820000000000001E-2," ",null," ",null," ",null,"Shin SY","24816252"]
[50,"rs10513801",3,"3q27.2","186104564","ETV5","T","Glomerular filtration rate in non diabetics (creatinine)","eGFRcrea",1.0000000000000001E-9,"1.067e-21",1.9939999999999999E-5," ",null," "," ",null," "," "," ",null," ",null,2.3910000000000001E-2,"T: eGFRcrea ↑; BMI ↑; EdAtt ↑ ","Pattaro C","26831199"]
[51,"rs5030062",3,"3q27.3","186736391","KNG1"," ","Blood metabolite levels",null,null," ",4.9390000000000003E-2," ",null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[52,"rs4686914",3,"3q27.3","187999752","LOC105374266 - LOC105374268"," ","Metabolite levels",null,null,1.5310000000000001E-2," "," ",null," "," ",null," "," "," ",null," ",null," ",null,"KIM, YJ","21909109"]
[53,"rs7642243",3,"3q29","196214345","LOC105374304"," ","Blood metabolite levels",null,null," ",2.5899999999999999E-3," ",null,3.27E-2," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[54,"rs938554",4,"4p16.1","9924068","SLC2A9"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null," ",3.9719999999999998E-2," ",null," ",null," ",null,"Shin SY","24816252"]
[54,"rs737267",4,"4p16.1","9933120","SLC2A9"," ","Blood metabolite levels",null,null," "," ",3.7859999999999998E-2,null," "," ",null," "," "," ",null," ",null," ",null,"Korostishevsky M",25898920]
[54,"rs4481233",4,"4p16.1","9954455","SLC2A9"," ","Metabolic traits",null,null," "," ",3.356E-2,null," "," ",null," ",3.4729999999999997E-2," ",null," ",null," ",null,"Suhre K","21886157"]
[540,"rs3099557",4,"4p15.2","22822398","GBA3 - LOC105374524"," ","Blood metabolite levels",null,null," "," ",3.539E-3,null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[56,"rs12507628",4,"4q13.3",72779634,"ADAMTS3 - HNRNPA1P67","A","Metabolite levels",null,"3,00E-009",null,null,null,6.9259999999999999E-3,{"$nulls":11},"Inouye M",22916037]
[57,"rs2168889",4,"4q13.3","74357994","LOC105377276 - EREG"," ","Metabolite levels",null,null," "," "," ",null," "," ",null," ",3.4390000000000002E-3," ",null," ",null," ",null,"Inouye M","22916037"]
[58,"rs17319721",4,"4q21.1","76447694","SHROOM3"," ","Glomerular filtration rate in non diabetics (creatinine)",null,null," "," "," ",null," "," ",null," "," "," ",null,7.0780000000000001E-3,null," ",null,"Pattaro C","26831199"]
[59,"rs10022462",4,"4q22.1","88322666","LOC105369192","C","Blood metabolite levels",null,"5,00E-011"," "," ",4.9700000000000001E-2,null," "," ",null," "," "," ",4.0169999999999997E-2," ",null," ",null,"Shin SY","24816252"]
[61,"rs228611",4,"4q24","102640552","MANBA"," ","Glomerular filtration rate (creatinin in serum)",null,null,5.8380000000000003E-3," "," ",null," ",7.6400000000000001E-3,null," "," "," ",null," ",null," ",null,"Pattaro C","26831199"]
[62,"rs2087160",4,"4q25","110413574","LOC105377362 - ENPEP"," ","Metabolic traits",null,null," ",4.854E-2," ",null," "," ",null," "," "," ",null," ",null," ",null,"Suhre K","21886157"]
[63,"rs13122250",4,"4q32.1",155887136,"LOC105377507 - TDO2","C",null,null,"9,00E-012",{"$nulls":10},3.4020000000000002E-2,null,3.9269999999999999E-2,null,null,"Shin SY",24816252]
[64,"rs4690909",4,"4q32.1","158707999","ETFDH"," ","Blood metabolite ratios",null,null," "," "," ",null," "," ",null," ",3.6580000000000001E-2," ",null," ",null," ",null,"Shin SY","24816252"]
[64,"rs8396",4,"4q32.1","158709665","PPID"," ","Metabolite levels",null,null," "," "," ",null," "," ",null," ",2.2530000000000001E-2," ",null,2.5329999999999998E-2,null," ",null,"Illig, T, Draisma HH, Shin SY, Suhre K","20037589, 26068415, 21886157, 24816252"]
[66,"rs1912826",4,"4q35.2","186228386","KLKB1"," ","Metabolite levels",null,null," "," "," ",null," "," ",null," ",1.163E-2," ",null,2.154E-2,null," ",null,"Inouye M","22916037"]
[66,"rs4241816",4,"4q35.2","186231173","KLKB1"," ","Metabolite levels",null,null," "," "," ",null," "," ",null," ",1.265E-2," ",null,2.196E-2,null," ",null,"Kettunen J","22286219"]
[66,"rs4253252",4,"4q35.2","186236304","KLKB1"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null," ",1.3610000000000001E-2," ",null,2.3519999999999999E-2,null," ",null,"Shin SY","24816252"]
[66,"rs3733402",4,"4q35.2","186236880","KLKB1"," ","Serum metabolite levels",null,null," "," "," ",null," "," ",null," ",1.371E-2," ",null,2.2550000000000001E-2,null," ",null,"YU B","24625756"]
[66,"rs4253311",4,"4q35.2","186253529","KLKB1"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null," ",1.193E-2," ",null,2.571E-2,null," ",null,"Shin SY","24816252"]
[69,"rs468327",5,"5p13.2","35003007","AGXT2","A","Urinary metabolites (H-NMR features)",null,"4,00E-015"," "," "," ",null," "," ",null," "," "," ",null,2.4709999999999999E-2,7.2150000000000001E-3," ",null,"Rueedi R","24586186"]
[69,"rs40200",5,"5p13.2","35045640","AGXT2"," ","Urinary metabolites (H-NMR features)",null,null," "," "," ",null," "," ",null," "," "," ",null," ",null,4.1700000000000001E-2,null,"Rueedi R","24586186"]
[70,"rs10491431",5,"5p13.2","35967898","UGT3A1"," ","Blood metabolite levels",null,null," "," "," ",null,null," ",null," "," "," ",null," ",null,3.3149999999999999E-2,null,"Shin SY","24816252"]
[71,"rs11959928",5,"5p13.1","39397030","DAB2"," ","Glomerular filtration rate (creatinin in serum)",null,null," "," "," ",null,3.3529999999999997E-2," ",null," "," "," ",null," ",null," ",null,"Pattaro C","26831199"]
[72,"rs12654264",5,"5q13.3","75352778","HMGCR","T","Metabolite levels","LDLc",9.9999999999999995E-21,1.808E-8,4.3099999999999996E-3," ",null," "," ",null," ",2.426E-2," ",null," ",2.725E-2," ","T: LDLc ↓; BMI ↓","KIM, YJ","21909109"]
[73,"rs17823642",5,"5q14.1","79045474","DMGDH"," ","Metabolite levels",null,null," "," "," ",null,2.5469999999999998E-3," ",null," "," "," ",null," ",null," ",null,"Xie W","23378610"]
[73,"rs16876394",5,"5q14.1","79050946","DMGDH"," ","Blood metabolite levels",null,null," "," "," ",null,2.4480000000000001E-3," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[73,"rs6453429",5,"5q14.1","79076038","BHMT2"," ","Urinary metabolites",null,null," "," ",2.2210000000000001E-2,null," "," ",null," "," "," ",null," ",null,3.0679999999999999E-2,null,"Raffler J","26352407"]
[74,"rs7727544",5,"5q31.1","132254841","P4HA2 - PDLIM4"," ","Blood metabolite levels",null,null," ",3.8980000000000001E-2," ",null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[74,"rs270601",5,"5q31.1","132321304","SLC22A4, LOC553103"," ","Acylcarnitine levels",null,null," "," "," ",null," "," ",null,1.4999999999999999E-2," "," ",null," ",null," ",null,"Draisma HH","26068415"]
[74,"rs273913",5,"5q31.1","132325463","LOC553103, SLC22A4"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null," ",4.3790000000000003E-2," ",null," ",null," ",null,"Shin SY","24816252"]
[74,"rs6893782",5,"5q31.1","132403741","SLC22A5 - C5orf56","A","Acylcarnitine levels","Acylcarnitine levels","1,00E-017"," "," "," ",null," ",1.213E-2,4.9209999999999997E-2," "," "," ",null," ",null," ",null,"Draisma HH","26068415"]
[74,"rs2405522",5,"5q31.1","132406004","SLC22A5 - C5orf56","A","Blood metabolite levels",null,"4,00E-029"," "," "," ",null," ",1.4149999999999999E-2,4.1579999999999999E-2,3.2000000000000001E-2," "," ",null," ",null," ",null,"Shin SY","24816252"]
[75,"rs10463316",5,"5q33.1","151366473","LOC105378234","A","Metabolite levels (Pyroglutamine)","Metabolite levels (Pyroglutamine)","2,00E-010"," "," "," ",null," ",3.2669999999999998E-2,null," "," ",2.9340000000000001E-2,null," ",1.325E-2," ","proxy rs869198","YU B","23934736"]
[76,"rs2545801",5,"5q35.3","177414338","F12"," ","Metabolite levels",null,null," ",2.9250000000000002E-2," ",null," "," ",null," "," ",1.4069999999999999E-2,null," ",null," ",null,"Kettunen J","22286219"]
[76,"rs2731672",5,"5q35.3","177415473","SLC34A1 - GRK6"," ","Blood metabolite ratios",null,null," ",4.3439999999999999E-2," ",null,2.4570000000000002E-2," ",null," "," ",1.7229999999999999E-2,null," ",null," ",null,"Inouye M, Shin SY","22916037, 24816252"]
[78,"rs2295602",6,"6p24.2","11005609","ELOVL2","C","Glycerophospholipid levels",null,"2,00E-013"," "," "," ",null," "," ",null,4.9997E-2," "," ",6.6940000000000001E-4," ",null,4.8599999999999997E-2,null,"Draisma HH",26068415]
[78,"rs3798722",6,"6p24.2","11040190","ELOVL2","A","Metabolite levels",null,"4,00E-009"," "," "," ",null," "," ",null,7.4000000000000003E-3," "," ",5.1330000000000004E-3," ",null," ",null,"Inouye M",22916037]
[78,"rs9393903",6,"6p24.2","11042676","ELOVL2","A","Metabolic traits",null,"2,00E-014"," "," "," ",null," "," ",null,9.5999999999999992E-3," "," ",3.1740000000000002E-3," ",null," ",null,"Suhre K","21886157"]
[78,"rs9393915",6,"6p24.2","11072089","ELOVL2-AS1","C","Blood metabolite ratios",null,"1,00E-022"," "," "," ",null," "," ",null,6.4999999999999997E-3," "," ",3.284E-3," ",null," ",null,"Shin SY","24816252"]
[78,"rs4713169",6,"6p24.2","11084321","ELOVL2-AS1 - SMIM13","C","Blood metabolite levels",null,"3,00E-014"," "," "," ",null," "," ",null,6.4000000000000003E-3," "," ",8.564E-4," ",null," ",null,"Shin SY","24816252"]
[80,"rs11754288",6,"6p22.2","25776721","SLC17A1, SLC17A4","A","Blood metabolite levels","X-11469",null," "," ",4.4560000000000002E-2,null,2.7E-4," ",null," "," "," ",1.189E-2," ",null," ","A: metab ↑; Schizo ↑","Shin SY","24816252"]
[80,"rs2762353",6,"6p22.2","25794203","SLC17A1","A","Blood metabolite levels","4-androsten-3beta,17beta-diol disulfate 2*",2.9999999999999998E-13," "," "," ",null,9.2E-5," ",null," "," "," ",6.2740000000000001E-3," ",null," ","A; metab ↑; Schizo ↑","Shin SY","24816252"]
[80,"rs1185567",6,"6p22.2","25818360","SLC17A1","A","Blood metabolite ratios","dehydroisoandrosterone sulfate (DHEA-S)/4-androsten-3beta,17beta-diol disulfate 2*",null," "," "," ",null,1.27E-4," ",null," "," "," ",9.8569999999999994E-3," ",null," ",null,"Shin SY","24816252"]
[81,"rs7759001",6,"6p22.1","27373630","ZNF204P","A","Glomerular filtration rate (creatinin in serum)","eGFRcrea",2E-8," ",1.7909999999999999E-2," ",null,9.4599999999999996E-5," ",null," ",3.594E-2," ",2.9390000000000002E-3," ",null," ","A: eGFRcrea ↓; Schizo ↓","Pattaro C","26831199"]
[85,"rs9296404",6,"6p21.1","42958065","CNPY3-GNMT"," ","Plasma homocysteine levels (post-methionine load test)",null,null," "," "," ",null," "," ",null," "," "," ",null,2.4709999999999999E-2,null," ",null,"Williams SR","24651765"]
[85,"rs881858",6,"6p21.1","43838872","LOC107986598"," ","Glomerular filtration rate in non diabetics (creatinine)",null,null,3.0839999999999999E-2," "," ",null," "," ",null,0.02," "," ",null," ",null," ",null,"Köttgen A, Pattaro C","20383146, 2683119"]
[85,"rs9472135",6,"6p21.1","43842065","LOC107986598"," ","Glomerular filtration rate (creatinin in serum)",null,null,4.5499999999999999E-2," "," ",null," "," ",null,2.98E-2," "," ",null," ",null," ",null,"Pattaro C","26831199"]
[86,"rs9473555",6,"6p12.3","49441774","MUT","C","Folate pathway vitamin levels","Folate pathway vitamin levels","5,00E-008"," "," "," ",1.6160000000000001E-2," "," ",null," ",1.546E-2," ",null," ",null," ",null,"Hazra A","19744961"]
[87,"rs494562",6,"6q14.3","85407411","LOC101928820 - DUTP5"," ","Blood metabolite levels",null,null," ",1.8429999999999998E-2," ",null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[90,"rs9400467",6,"6q21","111102812","SLC16A10","T","Blood metabolite levels","tyrosin",7.0000000000000005E-14," "," "," ",null,6.8770000000000004E-6," ",null," "," "," ",null," ",null," ","T: Tyrosin ↓; Schizo ↓","Shin SY, Draisma HH","24816252, 26068415"]
[90,"rs6901004",6,"6q21","111233619","LOC107986521"," ","Blood metabolite levels",null,null," "," ",9.7319999999999993E-3,null,2.9099999999999998E-3," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[90,"rs7760535",6,"6q21","111425880","REV3L"," ","Metabolic traits",null,null," "," "," ",null,1.0240000000000001E-2," ",null," "," "," ",null," ",null," ",null,"Suhre K","21886157"]
[90,"rs6900341",6,"6q21","111473206","REV3L"," ","Metabolite levels",null,null," ",1.251E-2," ",null,4.346E-3," ",null," "," "," ",null," ",null," ",null,"Kettunen J","22286219"]
[91,"rs6569474",6,"6q22.33","127172466","RSPO3, LOC105377988","A","Metabolite levels",null,"1,00E-008"," "," "," ",null,4.6739999999999997E-2," ",null," "," "," ",3.5499999999999997E-2," ",null," ",null,"KIM, YJ","21909109"]
[92,"rs2279463",6,"6q25.3","160247357","SLC22A2"," ","Glomerular filtration rate in non diabetics (creatinine)",null,null,2.6970000000000001E-2," ",8.9739999999999993E-3,null," "," ",null," "," "," ",null,4.376E-2,null," ",null,"Köttgen A, Pattaro C","20383146, 2683119"]
[94,"rs6968554",7,"7p21.1","17247482","LOC101927609","A","Blood metabolite levels",null,"9,00E-014",4.3639999999999998E-3," "," ",4.4859999999999997E-2," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[95,"rs3750082",7,"7p14.3",32880315,"KBTBD2","A","Glomerular filtration rate (creatinin in serum)","Glomerular filtration rate (creatinin in serum)","3,00E-008",{"$nulls":10},1.916E-2,{"$nulls":4},"Pattaro C",26831199]
[97,"rs7809234",7,"7p12.1","50542681","DDC, DDC-AS1"," ","Blood metabolite ratios",null,null,4.5499999999999999E-2," "," ",null," "," ",null," ",2.1389999999999999E-2," ",null," ",null," ",null,"Shin SY","24816252"]
[100,"rs13247874",7,"7q11.23",73596112,"MLXIPL",{"$nulls":4},1.9699999999999999E-2,{"$nulls":13},"proxy rs1051921","Kettunen J","22286219"]
[101,"rs6465825",7,"7q11.23",77787122,"RSBN1L - TMEM60","T",null,"Chronic kidney disease","2,00E-009",{"$nulls":6},1.3950000000000001E-2,{"$nulls":8},"Köttgen A",20383146]
[101,"rs6465825",7,"7q11.23",77787122,"RSBN1L - TMEM60","T","Glomerular filtration rate in non diabetics (creatinine)","Glomerular filtration rate in non diabetics (creatinine)","5,00E-011",{"$nulls":6},1.3950000000000001E-2,{"$nulls":8},"Pattaro C",26831199]
[102,"rs848490",7,"7q21.11","77925688","PHTF2"," ","Glomerular filtration rate (creatinin in serum)",null,null," ",4.3459999999999999E-2," ",null," "," ",null," "," "," ",null," ",null," ",null,"Pattaro C","26831199"]
[103,"rs2057681",7,"7q21.3",95308945,"PON1",{"$nulls":15},4.1169999999999998E-2,null,null,null,"Hong MG"]
[104,"rs148982377",7,"7q22.1","99477415","ZNF789","C","Sex hormone levels",null,"2,00E-014"," ",3.7960000000000001E-2," ",2.8160000000000001E-2," "," ",null," "," "," ",null," ",null," ",null,"Ruth KS","26014426"]
[104,"rs12533251",7,"7q22.1","99518054","ZKSCAN5","A","Blood metabolite levels",null,"2,00E-011",1.9089999999999999E-2,4.308E-2," ",3.9280000000000002E-2," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[104,"rs34670419",7,"7q22.1","99533211","ZKSCAN5","T","Sex hormone levels",null,"2,00E-014"," ",3.7749999999999999E-2," ",3.2849999999999997E-2," "," ",null," "," "," ",null," ",null," ",null,"Ruth KS","26014426"]
[104,"rs10278040",7,"7q22.1","99543750","LOC100419451 - FAM200A"," ","Blood metabolite levels",null,null," ",3.3020000000000001E-2," ",null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[104,"rs11974702",7,"7q22.1","99566328","ZNF655"," ","Blood metabolite levels",null,null,1.6400000000000001E-2,2.836E-2," ",null," "," ",null," "," "," ",null," ",null," ","proxy rs11981478","Shin SY","24816252"]
[104,"rs7809615",7,"7q22.1","99587155","ZNF655 - GS1-259H13.2","T","Blood metabolite ratios",null,"8,00E-139",1.5720000000000001E-2,1.078E-2," ",1.2749999999999999E-2," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[104,"rs4646450",7,"7q22.1","99668695","ZSCAN25, CYP3A5"," ","Blood metabolite levels",null,null,3.125E-2," "," ",3.2849999999999997E-2," "," ",null," "," "," ",null," ",null," ",null,"Korostishevsky M","25898920"]
[104,"rs17277546",7,"7q22.1",99891948,"TRIM4","A","Metabolic traits",null,"9,00E-040",{"$nulls":10},2.1649999999999999E-2,null,4.6249999999999999E-2,null,null,"Suhre K",21886157]
[106,"rs3800993",7,"7q34","142101207","MGAM"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[107,"rs1005390",7,"7q36.1","150846633","AOC1, LOC105375567"," ","Blood metabolite ratios",null,null," "," "," ",null,2.8570000000000002E-2," ",null,4.7699999999999999E-3," "," ",null," ",null," ",null,"Shin SY","24816252"]
[109,"rs4841132",8,"8p23.1","9326086","LOC157273","n.a.","Metabolite levels","M-HDL-FC (Free cholesterol in medium HDL)",2.0000000000000001E-9," "," ",1.2440000000000001E-3,null,1.3519999999999999E-5," ",null," "," "," ",null," ",null," ",null,"Inouye M","22916037"]
[110,"rs4921913",8,"8p22","18414867","NAT2 - PSD3"," ","Blood metabolite ratios",null,null,1.32E-2," "," ",null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[110,"rs4921914",8,"8p22","18414928","NAT2 - PSD3"," ","Blood metabolite levels",null,null,1.2840000000000001E-2," "," ",null," "," ",null," "," "," ",null," ",null," ",null,"Suhre K, Shin SY, Rueedi R","21886157, 24816252, 24586186"]
[110,"rs35246381",8,"8p22",18415025,"NAT2 - PSD3",null,"Urinary metabolites",null,null,1.5980000000000001E-2,{"$nulls":14},"Raffler J"]
[111,"rs331",8,"8p21.3","19962894","LPL"," ","Lipid metabolism phenotypes",null,null," ",4.0599999999999997E-2," ",null," "," ",null," "," "," ",null," ",null," ",null,"Chasman DI","19936222"]
[111,"rs1059611",8,"8p21.3","19967052","LPL"," ","Lipid metabolism phenotypes",null,null," ",3.1849999999999999E-3," ",null," "," ",null," "," "," ",null," ",null," ",null,"Chasman DI","19936222"]
[111,"rs17482753",8,"8p21.3","19975135","LPL - LOC105379311"," ","Lipid traits",null,null," ",2.2829999999999999E-3," ",null," "," ",null," "," "," ",null," ",null,4.394E-2,null,"Keller M","24023261"]
[111,"rs12678919",8,"8p21.3","19986711","LPL - LOC105379311"," ","Metabolite levels",null,null," ",6.5669999999999999E-3," ",null," "," ",null," "," "," ",null," ",null,1.779E-2,null,"Inouye M","22916037"]
[111,"rs115849089",8,"8p21.3","20054859","LPL - LOC105379311"," ","Lipid metabolism phenotypes",null,null," ",2.434E-3," ",null," "," ",null," "," "," ",null," ",null,2.8119999999999999E-2,"proxy rs17411024","Kettunen J","22286219"]
[112,"rs3758086",8,"8p21.2","23857479","STC1 - LOC107986931"," ","Glomerular filtration rate (creatinin in serum)",null,null," "," "," ",null,4.0379999999999999E-2," ",null," "," "," ",null," ",null," ",null,"Pattaro C","26831199"]
[114,"rs2160860",8,"8p11.21","39965626","IDO2"," ","Blood metabolite levels",null,null," ",2.5460000000000001E-3," ",null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[115,"rs17641971",8,"8q11.21","48972258","LOC107986942 - C8orf22"," ","Blood metabolite levels",null,null," "," "," ",null,3.0360000000000002E-2," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[115,"rs10504073",8,"8q11.21","49112385","C8orf22 - LOC105375826"," ","Blood metabolite ratios",null,null," "," "," ",null,2.379E-3," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[116,"rs1030420",8,"8q13.1",66448490,"ADHFE1","C","Blood metabolite levels",null,"1,00E-011",{"$nulls":10},2.4289999999999999E-2,{"$nulls":4},"Shin SY",24816252]
[117,"rs6982636",8,"8q24.13","125467073","TRIB1 - LOC105375746"," ","Lipid metabolism phenotypes",null,null,1.268E-2," "," ",null," "," ",null," "," "," ",null," ",null," ",null,"Chasman DI","19936222"]
[119,"rs4744712",9,"9q21.11",68819791,"PIP5K1B",null,"Glomerular filtration rate (creatinin in serum)",{"$nulls":17},"Pattaro C, Köttgen A","20383146, 2683119"]
[121,"rs2575876",9,"9q31.1","104903458","ABCA1","A","Lipid metabolism phenotypes",null,"2,00E-011",1.312E-2," "," ",3.424E-3," "," ",null," "," "," ",null," ",null," ",null,"Kettunen J","22286219"]
[122,"rs15676",9,"9q34.11","128809748","TBC1D13","A","Blood metabolite levels","indolelactate",9.9999999999999998E-13,4.96E-3," "," ",null,4.5099999999999998E-5," ",null," "," ",3.0859999999999999E-2,null," ",null,4.53E-2,"A: metab ↑; Schizo ↑","Shin SY","24816252"]
[122,"rs7849270",9,"9q34.11","129112362","PPP2R4"," ","Blood metabolite ratios",null,null," "," "," ",null,1.268E-2,2.1950000000000001E-2,null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[122,"rs10988217",9,"9q34.11","129125837","PPP2R4"," ","Blood metabolite levels",null,null," "," "," ",null," ",4.265E-2,null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[123,"rs651007",9,"9q34.2","133278431","ABO - LCN1P2","C","Metabolite levels",null,"6,00E-009"," "," "," ",null," "," ",null," "," "," ",2.7109999999999999E-2,2.9309999999999999E-2,null," ",null,"Kim YJ","21909109"]
[123,"rs651007",9,"9q34.2",133278431,"ABO - LCN1P2","C","Blood metabolite levels",null,"6,00E-020",{"$nulls":10},2.7109999999999999E-2,{"$nulls":4},"Shin SY",24816252]
[123,"rs579459",9,"9q34.2","133278724","ABO_-_LCN1P2","C","Blood metabolite ratios","ADpSGEGDFXAEGGGVR*/X-14304--leucylalanine","1,00E-028"," "," "," ",null," "," ",null," ",4.8829999999999998E-2," ",2.1520000000000001E-2,3.2759999999999997E-2,null," ",null,"Shin SY","24586186"]
[123,"rs579459",9,"9q34.2",133278724,"ABO - LCN1P2","C","Urinary metabolites (H-NMR features)",null,"2,00E-032",{"$nulls":10},2.1520000000000001E-2,{"$nulls":4},"Rueedi R",24586186]
[123,"rs649129",9,"9q34.2","133278860","ABO - LCN1P2","C","Blood metabolite ratios",null,"9,00E-037"," "," "," ",null," "," ",null," "," "," ",2.0840000000000001E-2,3.3189999999999997E-2,null," ",null,"Shin SY","24816252"]
[123,"rs495828",9,"9q34.2","133279294","ABO - LCN1P2","G","Blood metabolite ratios",null,"6,00E-034"," "," "," ",null," "," ",null," "," "," ",2.444E-2,3.304E-2,null," ",null,"Shin SY","24816252"]
[124,"rs687289",9,"9p34.2","136137106","ABO","A","Urinary metabolites (H-NMR features)",null,"2,00E-012"," "," "," ",null," "," ",null," "," "," ",3.5340000000000003E-2,1.0019999999999999E-2,null," ",null,"Rueedi R","24586186"]
[124,"rs657152",9,"9p34.2","136139265"," "," ","Urinary metabolites (H-NMR features)",null,null," "," "," ",null," "," ",null," "," "," ",null,6.1700000000000001E-3,null," ",null,"Rueedi R","24586186"]
[124,"rs612169",9,"9p34.2",136143442,"ABO","A","Metabolic traits",null,"9,00E-040"," "," "," ",null," "," ",null," ",2.478E-2," ",4.2810000000000001E-2,2.4819999999999998E-2,null," ",null,"Suhre K","21886157"]
[125,"rs12246027",10,"10p15.3","272136","LOC107984191"," ","Blood metabolite levels",null,null," ",2.4230000000000002E-2," ",null,1.387E-3," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[125,"rs1044261",10,"10p15.3","1019770","IDI2"," ","Glomerular filtration rate (creatinin in serum)",null,null," "," ",3.2370000000000003E-2,null," "," ",null," "," "," ",null," ",null," ",null,"Pattaro C","26831199"]
[125,"rs10794720",10,"10p15.3","1110225","WDR37"," ","Chronic kidney disease","Glomerular filtr. Rate and Chronic kidney disease","5E-08, 1E-08"," "," ",3.0810000000000001E-2,null," "," ",null," ",9.7619999999999998E-3,3.499E-2,1.549E-2," ",null," ",null,"Köttgen A, Pattaro C","20383146, 2683119"]
[127,"rs10795433",10,"10p13","16927924","CUBN"," ","Urinary albumin-to-creatinine ratio",null,null," ",1.9460000000000002E-2," ",null," "," ",null," "," "," ",null," ",null," ",null,"Teumer A","26631737"]
[127,"rs1801222",10,"10p13","17114152","CUBN","A","Folate pathway vitamin levels","Folate pathway vitamin levels","3,00E-009"," ",8.4480000000000006E-3," ",null," "," ",6.7039999999999999E-3," "," "," ",null," ",null," ",null,"Hazra A","19744961"]
[129,"rs2291429",10,"10q11.21","45958881",null,null,"Blood metabolite levels",{"$nulls":11},3.5700000000000003E-2,{"$nulls":5},"Shin SY","24816252"]
[130,"rs10994860",10,"10q11.23","50885664","A1CF","T","Glomerular filtration rate in non diabetics (creatinine)","Glomerular filtration rate in non diabetics (creatinine)","1,00E-012"," "," "," ",null," "," ",2.9619999999999998E-3,3.8899999999999997E-2," "," ",null," ",null," ",null,"Pattaro C","26831199"]
[131,"rs12356193",10,"10q21.2","59653595","SLC16A9","G","Blood metabolite levels",null,"8,00E-020"," ",1.602E-2," ",3.8089999999999999E-2," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[131,"rs1171606",10,"10q21.2","59674761","SLC16A9"," ","Acylcarnitine levels",null,null," "," ",3.3439999999999998E-2,null,3.0849999999999999E-2," ",null," "," "," ",null," ",null," ",null,"Draisma HH","26068415"]
[133,"rs4986894",10,"10q23.33","94762608","CYP2C18 - CYP2C19","C","Blood metabolite levels",null,"6,00E-012"," "," "," ",null," "," ",null," "," "," ",4.237E-4," ",null," ",null,"Shin SY","24816252"]
[133,"rs1853207",10,"10q23.33","94906180","CYP2C9"," ","Blood metabolite levels",null,null," "," ",2.2419999999999999E-2,null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[133,"rs1934963",10,"10q23.33","94974919","CYP2C9"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null," ",6.2740000000000001E-3," ",null," ",null," ",null,"Shin SY","24816252"]
[135,"rs11598867",10,"10q24.2","98386327","PYROXD2"," ","Urinary metabolites",null,null," ",3.4660000000000003E-2," ",null,9.2279999999999999E-4," ",null," "," "," ",null," ",null," ",null,"Raffler J","26352407"]
[135,"rs4345897",10,"10q24.2","98387303","PYROXD2"," ","Metabolite levels",null,null," ",2.298E-2," ",null,3.2100000000000002E-3," ",null," "," "," ",null," ",null," ",null,"Hong, MG, Rueedi R","23281178, 24586186"]
[135,"rs4539242",10,"10q24.2","98388301","PYROXD2"," ","Urinary metabolites (H-NMR features)",null,null," ",2.5049999999999999E-2," ",null,8.5930000000000002E-4," ",null," "," "," ",null," ",null," ",null,"Rueedi R","24586186"]
[135,"rs2147896",10,"10q24.2","98388419","PYROXD2"," ","Urinary metabolites (H-NMR features)",null,null," ",2.6179999999999998E-2," ",null,8.1340000000000004E-4," ",null," "," "," ",null," ",null," ",null,"Rueedi R","24586186"]
[135,"rs7072216",10,"10q24.2","98397096","PYROXD2"," ","Metabolite levels",null,null," ",2.9819999999999999E-2," ",null,1.4450000000000001E-3," ",null," "," "," ",null," ",null," ",null,"Nicholson G",21931564]
[135,"rs4488133",10,"10q24.2","98399379","PYROXD2"," ","Blood metabolite levels",null,null," "," "," ",null,7.804E-4," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[137,"rs9527",10,"10q24.32","102863821","C10orf32, C10orf32-ASMT","A","Arsenic metabolism","DMA%  (dimethylarsinic acid % in urine)",3E-9," ",2.8000000000000001E-2," ",null,1.218E-5," ",null," "," "," ",null," ",null," ",null,"Pierce","22383894"]
[137,"rs4919694",10,"10q24.32","102939221","CNNM2","C","Arsenic metabolism","Arsenic metabolism","3,00E-008"," "," "," ",4.4790000000000003E-2," "," ",null," "," "," ",null,1.0059999999999999E-2,null," ",null,"Pierce BL","22383894"]
[139,"rs163160",11,"11p15.5","2768725","KCNQ1","A","Glomerular filtration rate in non diabetics (creatinine)","Glomerular filtration rate in non diabetics (creatinine)","2,00E-009"," "," "," ",null,1.8599999999999998E-2," ",2.862E-2," "," "," ",null,1.384E-2,null," ",null,"Pattaro C","26831199"]
[140,"rs10741657",11,"11p15.2","14893332","CYP2R1"," ","Vitamin D insufficiency",null,null,2.3630000000000002E-2," "," ",null,3.7920000000000002E-2," ",null," "," ",1.839E-2,null," ",null," ","proxy rs2060793","Wang TJ","20541252"]
[141,"rs2403254",11,"11p15.1","18303599","HPS5"," ","Blood metabolite levels",null,null,3.0939999999999999E-2," "," ",1.5900000000000001E-2," "," ",null," "," "," ",null," ",null," ",null,"Suhre K, Shin SY","24816252, 21886157"]
[141,"rs4150581",11,"11p15.1","18335723","GTF2H1"," ","Blood metabolite ratios",null,null,3.7620000000000001E-2," "," ",2.579E-2," "," ",null," "," "," ",null," ",null,4.4830000000000002E-2,null,"Shin SY","24816252"]
[142,"rs963837",11,"11p14.1","30727543","LOC101928316"," ","Glomerular filtration rate (creatinin in serum)",null,null," ",1.131E-4," ",null," "," ",null," "," "," ",null," ",null," ",null,"Pattaro C","26831199"]
[142,"rs3925584",11,"11p14.1","30738788","LOC101928338"," ","Glomerular filtration rate in non diabetics (creatinine)",null,null," ",3.7310000000000002E-4," ",null," "," ",null," "," "," ",null," ",null," ",null,"Pattaro C","26831199"]
[144,"rs174535",11,"11q12.2",61783884,"MYRF","C","Blood metabolite levels",null,"3,00E-036",{"$nulls":10},7.6369999999999997E-4,{"$nulls":4},"Shin SY",24816252]
[144,"rs174536",11,"11q12.2",61784455,"MYRF","A","Glycerophospholipid levels",null,"5,00E-059",{"$nulls":10},8.2209999999999998E-4,{"$nulls":4},"Draisma HH",26068415]
[144,"rs174537",11,"11q12.2","61785208","MYRF","G","Glycerophospholipid levels",null,"3,00E-019"," "," "," ",null," "," ",null," ",4.045E-3," ",8.0840000000000003E-4," ",null," ",null," ","26068415"]
[144,"rs102275",11,"11q12.2",61790331,"TMEM258","C","Glycerophospholipid levels",null,"2,00E-041",{"$nulls":10},7.2159999999999998E-4,{"$nulls":4},"Draisma HH",26068415]
[144,"rs102275",11,"11q12.2",61790331,"TMEM258","C","Metabolite levels",null,"4,00E-264",{"$nulls":10},7.2159999999999998E-4,{"$nulls":4},"Inouye M",22916037]
[144,"rs174538",11,"11q12.2","61792609","TMEM258","A","Blood metabolite levels",null,"9,00E-014"," "," "," ",null," "," ",null," ",3.3689999999999998E-2," ",4.0229999999999997E-3," ",null," ",null,"Shin SY","24816252"]
[144,"rs174541",11,"11q12.2",61798436,"FEN1 - FADS1","C","Metabolite levels",null,"3,00E-009",{"$nulls":10},2.2759999999999998E-3,null,3.952E-2,null,null,"Xie W",23378610]
[144,"rs174546",11,"11q12.2",61802358,"FADS1","C","Glycerophospholipid levels",null,"6,00E-020",{"$nulls":8},3.3600000000000001E-3,null,1.6479999999999999E-3,{"$nulls":4},"Draisma HH",26068415]
[144,"rs174547",11,"11q12.2","61803311","FADS1"," ","Lipid metabolism phenotypes",null,null," "," "," ",null," "," ",null," ",5.2490000000000002E-3," ",2.2820000000000002E-3," ",null," ",null,"Illig, T, Draisma HH, Kettunen J, Suhre K","20037589, 26068415,  22286219, 21886157"]
[144,"rs174548",11,"11q12.2","61803876","FADS1","C","Blood metabolite ratios",null,"5,00E-008"," "," "," ",null," "," ",null," ",8.1459999999999996E-4," ",3.0490000000000001E-3," ",null," ",null,"Gieger C","19043545"]
[144,"rs174548",11,"11q12.2",61803876,"FADS1","C","Blood metabolite levels",null,"1,00E-084",{"$nulls":10},3.0490000000000001E-3,{"$nulls":4},"Shin SY ",24816252]
[144,"rs174548",11,"11q12.2",61803876,"FADS1","C","Blood metabolite ratios",{"$nulls":12},3.0490000000000001E-3,{"$nulls":4},"Shin SY ",24816252]
[144,"rs174549",11,"11q12.2","61803910","FADS1"," ","Metabolite levels",null,null," "," "," ",null," "," ",null," ",1.145E-3," ",4.1240000000000001E-3," ",null," ",null,"Hong, MG","23281178"]
[144,"rs174550",11,"11q12.2","61804006","FADS1","C","Blood metabolite levels","adrenate (22:4n6)","7,00E-024"," "," "," ",null," "," ",null," ",4.6649999999999999E-3," ",1.1620000000000001E-3," ",null," ",null,"Shin SY","26068415"]
[144,"rs174550",11,"11q12.2",61804006,"FADS1","C","Glycerophospholipid levels",null,"4,00E-033",{"$nulls":10},1.1620000000000001E-3,{"$nulls":4},"Draisma HH",26068415]
[144,"rs174555",11,"11q12.2","61812288","FADS1","C","Glycerophospholipid levels",null,"1,00E-035"," "," "," ",null," "," ",null," ",1.2179999999999999E-3," ",2.5630000000000002E-3," ",null," ",null,"Draisma HH","26068415"]
[144,"rs174556",11,"11q12.2","61813163","FADS1","C","Blood metabolite levels",null,"2,00E-022"," "," "," ",null," "," ",null," ",1.3669999999999999E-3," ",3.2169999999999998E-3," ",null," ",null,"Shin SY","24816252"]
[144,"rs968567",11,"11q12.2","61828092","FADS2","C","Blood metabolite levels",null,"3,00E-019"," "," "," ",null," "," ",null," "," "," ",6.9059999999999998E-3," ",null,2.5510000000000001E-2,null,"Shin SY","24816252"]
[144,"rs968567",11,"11q12.2",61828092,"FADS2","C","Glycerophospholipid levels",null,"1,00E-018",{"$nulls":10},6.9059999999999998E-3,{"$nulls":4},"Draisma HH",26068415]
[144,"rs1535",11,"11q12.2",61830500,"FADS2","A","Glycerophospholipid levels",null,"8,00E-048",{"$nulls":10},8.6729999999999999E-4,{"$nulls":4},"Draisma HH",26068415]
[144,"rs2727271",11,"11q12.2","61835886","FADS2"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null," ",2.588E-3," ",null," ",null," ",null,"Shin SY","24816252"]
[144,"rs174576",11,"11q12.2",61836038,"FADS2","A","Glycerophospholipid levels",null,"1,00E-017",{"$nulls":10},5.1570000000000001E-4,null,4.3799999999999999E-2,null,null,"Draisma HH",26068415]
[144,"rs174578",11,"11q12.2",61838027,"FADS2","A","Blood metabolite levels",null,"3,00E-024",{"$nulls":10},8.4979999999999995E-4,null,4.1189999999999997E-2,null,null,"Shin SY",24816252]
[144,"rs174578",11,"11q12.2",61838027,"FADS2","A","Glycerophospholipid levels",null,"2,00E-043",{"$nulls":10},8.4979999999999995E-4,null,4.1189999999999997E-2,null,null,"Draisma HH",26068415]
[144,"rs174601",11,"11q12.2",61855668,"FADS2","C","Blood metabolite levels",null,"8,00E-016",{"$nulls":10},1.9070000000000001E-3,{"$nulls":4},"Shin SY",24816252]
[145,"rs4014195",11,"11q13.1","65739351","KRT8P26 - AP5B1"," ","Glomerular filtration rate (creatinin in serum)",null,null," "," "," ",null," ",2.0160000000000001E-2,null," "," "," ",null," ",null," ",null,"Pattaro C","26831199"]
[146,"rs12288023",11,"11q13.2","67653870","ACY3 - ALDH3B2"," ","Serum metabolite levels",null,null," "," ",4.2549999999999998E-2,null,4.8750000000000002E-2," ",null," "," "," ",null," ",null," ",null,"YU,B","24625756"]
[147,"rs17610395",11,"11q13.3","68794860","CPT1A"," ","Lipid metabolism phenotypes",null,null," "," "," ",null," "," ",null," "," "," ",null," ",null,4.3900000000000002E-2,null,"Kettunen J","22286219"]
[148,"rs12785878",11,"11q13.4","71456403","NADSYN1","T","Vitamin D insufficiency","Vitamin D insufficiency",2.0000000000000001E-27," "," "," ",null," "," ",null," "," "," ",null," ",null,4.0309999999999999E-5,null,"Wang TJ","20541252"]
[149,"rs10830962",11,"11q14.3","92965261","LOC105369431 - MTNR1B"," ","Metabolite levels",null,null,4.3389999999999998E-2," "," ",null," "," ",null," "," "," ",null," ",null," ",null,"KIM, YJ","21909109"]
[149,"rs10830963",11,"11q14.3","92975544","MTNR1B"," ","Metabolite levels",null,null," "," "," ",null,1.9900000000000001E-2," ",null," "," "," ",null," ",null," ",null,"Kettunen J","22286219"]
[150,"rs964184",11,"11q23.3","116778201","ZPR1"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null,4.5490000000000003E-2," "," ",null," ",null," ",null,"Shin SY","24816252"]
[153,"rs499368",12,"12p13.33",211754,"SLC6A12","T","Metabolite levels",null,"2,00E-010",null,null,null,2.248E-2,{"$nulls":11},"Xie W",23378610]
[153,"rs499368",12,"12p13.33",211754,"SLC6A12","T","Blood metabolite levels",null,"8,00E-013",null,null,null,2.248E-2,{"$nulls":11},"Shin SY",24816252]
[153,"rs11062102",12,"12p13.33","239619","SLC6A13","T","Urinary metabolites",null,"1,00E-017"," "," "," ",null," "," ",null," "," "," ",null,7.9019999999999993E-3,2.1219999999999999E-2," ",null,"Raffler J","26352407"]
[153,"rs10774021",12,"12p13.33","240132","SLC6A13"," ","Glomerular filtration rate in non diabetics (creatinine)",null,null," "," "," ",null," "," ",null," "," "," ",null,6.1110000000000001E-3,null," ",null,"Pattaro C","26831199"]
[153,"rs11613331",12,"12p13.33","242301","SLC6A13"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null," "," "," ",null,2.972E-2,null," ",null,"Shin SY","24816252"]
[153,"rs7969761",12,"12p13.33","246676","SLC6A13"," ","Blood metabolite ratios",null,null," "," "," ",null," "," ",null," "," "," ",null,2.0809999999999999E-2,null," ",null,"Shin SY","24816252"]
[155,"rs7956634",12,"12p12.3","15168260","RERG"," ","Glomerular filtration rate (creatinin in serum)",null,null," ",2.1000000000000001E-2," ",null," "," ",null," "," "," ",null," ",null," ",null,"Pattaro C","26831199"]
[156,"rs4149056",12,"12p12.1","21178615","SLCO1B1"," ","Blood metabolite ratios",null,null," "," ",1.519E-2,null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[156,"rs1871395",12,"12p12.1","21199381","SLCO1B1"," ","Blood metabolite levels",null,null," "," ",1.934E-2,null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[156,"rs12317268",12,"12p12.1","21199607","SLCO1B1"," ","Blood metabolite levels",null,null," "," ",1.439E-2,null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[156,"rs4363657",12,"12p12.1","21215788","SLCO1B1"," ","Blood metabolite levels",null,null," "," ",4.8210000000000003E-2,null," "," ",null,2.8819999999999998E-2," "," ",null," ",null," ",null,"Korostishevsky M","25898920"]
[156,"rs4149081",12,"12p12.1","21225087","SLCO1B1"," ","Metabolic traits",null,null," "," ",2.486E-2,null," "," ",null,4.2900000000000001E-2," "," ",null," ",null," ",null,"Suhre K, Shin SY","21886157"]
[156,"rs11045879",12,"12p12.1","21229685","SLCO1B1"," ","Metabolite levels",null,null," "," ",2.6960000000000001E-2,null," "," ",null,4.7690000000000003E-2," "," ",null," ",null," ",null,"Hong, MG","23281178"]
[156,"rs12829704",12,"12p12.1","21235687","SLCO1B1"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null," "," "," ",null," ",null,4.3979999999999998E-2,null,"Shin SY","24816252"]
[157,"rs2657880",12,"12q13.3",56469986,"SPRYD4","C","Metabolite levels",null,"7,00E-030",null,null,null,2.298E-2,{"$nulls":11},"Inouye M",22916037]
[157,"rs2638315",12,"12q13.3",56471272,"GLS2","C","Metabolite levels",null,"2,00E-035",null,null,null,7.1650000000000004E-3,{"$nulls":11},"Kettunen J",22286219]
[157,"rs2657879",12,"12q13.3","56471554","GLS2"," ","Blood metabolite levels",null,"2E-14, 3E-17, 6E-18",2.3910000000000001E-2," "," ",2.419E-2," "," ",null," "," "," ",null," ",null," ",null,"Suhre K, Shin SY, Draisma HH","21886157, 24816252, 26068415"]
[157,"rs2694917",12,"12q13.3",56519080,"HSPD1P4 - RBMS2","C","Blood metabolite ratios",null,"2,00E-029",null,null,null,8.5170000000000003E-3,{"$nulls":11},"Shin SY",24816252]
[157,"rs1106766",12,"12q13.3","57415673","R3HDM2"," ","Glomerular filtration rate (creatinin in serum)",null,null," "," ",4.091E-3,null,1.2959999999999999E-2,1.6070000000000001E-2,null," "," "," ",null," ",null," ",null,"Pattaro C","26831199"]
[159,"rs3184504",12,"12q24.12","111446804","SH2B3","T","Blood metabolite levels","kynurenine",5.9999999999999997E-18,9.3489999999999998E-6," "," ",null," "," ",null," "," "," ",null," ",null," ","T: kynurenine ↑; BMI ↓","Shin SY","24816252"]
[161,"rs2066938",12,"12q24.31","120722812","UNC119B","A","Blood metabolite levels","Shin: butyrylcarnitine; suhre: butyrylcarnitine /propionylcarnitine","3,1E-630 (Shin)"," ",4.4000000000000002E-6," ",null,4.6900000000000002E-4," ",null," "," "," ",null," ",null," ","A: metab  ↓; edAtt ↑","Suhre K, Shin SY","24816252, 21886157"]
[161,"rs2014355",12,"12q24.31","120737721","ACADS","T","Metabolite levels","C3/C4",4.9999999999999999E-96," ",4.9899999999999997E-6," ",null,1.0200000000000001E-3," ",null," "," "," ",null," ",null," ","T: C3/C4 ↓; edAtt  ↑","Illig, T","20037589"]
[161,"rs3916",12,"12q24.31","120739469","ACADS","G","Urinary_metabolites_(H-NMR_features)","unknown",2.4E-22," ",3.1599999999999998E-6," ",null,1.41E-3," ",null," "," "," ",null," ",null," ","n.a.","Rueedi R","24586186"]
[162,"rs4760099",12,"12q24.31",121880817,"HPD","A","Urinary metabolites",null,"2,00E-080",null,null,null,2.581E-2,{"$nulls":11},"Raffler J",26352407]
[162,"rs4760099",12,"12q24.31","122318723","HPD","A","Urinary metabolites",null,"2,00E-080",{"$nulls":10},3.8199999999999998E-2,null,null,null,"proxy rs2230681","Raffler J",26352407]
[162,"rs7314056",12,"12q24.31",121905058,"PSMD9","C","Urinary metabolites (H-NMR features)",null,"4,00E-016",{"$nulls":10},3.925E-2,{"$nulls":4},"Rueedi R","24586186"]
[162,"rs1916333",12,"12q24.31","122458637","HPD","T","Urinary metabolites",null,"7,00E-078",{"$nulls":10},1.4109999999999999E-2,null,null,null,"proxy rs1169093","Raffler J",26352407]
[163,"rs626277",13,"13q21.33","71773564","DACH1","C","Chronic kidney disease","Chronic kidney disease","3,00E-011"," "," "," ",1.503E-3,1.102E-2," ",null," "," "," ",null," ",null," ",null,"Köttgen A","20383146"]
[164,"rs8002180",13,"13q32.1","95270511","ABCC4","C","Blood metabolite levels",null,"8,00E-023"," "," "," ",null," "," ",null," ",8.7259999999999994E-3," ",1.276E-3," ",null," ",null,"Shin SY","24816252"]
[165,"rs4902243",14,"14q23.2","63767525","SYNE2"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null," "," "," ",null,4.41E-2,null," ",null,"Shin SY","24816252"]
[167,"rs2041073",14,"14q24.3","73505831","ACOT1, HEATR4","C","Blood metabolite levels",null,"3,00E-013"," "," "," ",null,2.0540000000000001E-4," ",6.7289999999999997E-3," "," "," ",2.5180000000000001E-2," ",null," ",null,"Shin SY","24816252"]
[167,"rs8018967",14,"14q24.3","73510230","ACOT1, HEATR4"," ","Blood metabolite ratios",null,null,3.8240000000000003E-2," "," ",null,3.6650000000000002E-4," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[168,"rs4144027",14,"14q32.33","103891301","LOC105370690","T","Blood metabolite levels","aspargine",9.9999999999999994E-12,1.9179999999999999E-2," "," ",null,2.3300000000000001E-5," ",null,2.0449999999999999E-2," ",3.338E-2,3.7940000000000002E-2," ",null," ","T: Aspargine ↑; Schizo ↓; proxy rs4900601","Shin SY","24816252"]
[169,"rs10518693",15,"15q15.1","40407823","IVD"," ","Metabolic traits",null,null," "," "," ",null," "," ",null," "," "," ",null,2.7439999999999999E-2,null," ",null,"Suhre K",21886157]
[169,"rs9635324",15,"15q15.1","40411012","IVD"," ","Blood metabolite ratios",null,null," "," "," ",null," "," ",null,4.317E-2," "," ",null,4.2029999999999998E-2,null," ",null,"Shin SY","24816252"]
[169,"rs476633",15,"15q15.1","41099936","INO80"," ","Glomerular filtration rate (creatinin in serum)",null,null," "," ",4.7160000000000001E-2,null," ",4.0399999999999998E-2,null," "," "," ",null," ",null," ",null,"Pattaro C","26831199"]
[169,"rs2928148",15,"15q15.1","41109352","INO80"," ","Glomerular filtration rate in non diabetics (creatinine)",null,null," "," ",3.4340000000000002E-2,null," "," ",null," "," "," ",null," ",null,3.9730000000000001E-2,"proxy rs1678750","Pattaro C","26831199"]
[170,"rs2453533",15,"15q21.1","45349027","LOC100533853 - RNU6-953P"," ","Glomerular filtration rate in non diabetics (creatinine)",null,null,1.439E-2," "," ",null," "," ",null," "," "," ",null," ",null," ",null,"Köttgen A, Pattaro C","20383146, 2683119"]
[173,"rs2467853",15,"15q21.1","45406595","SPATA5L1"," ","Glomerular filtration rate (creatinin in serum)",null,null,5.1609999999999998E-3," "," ",null," "," ",null," "," "," ",null," ",null," ",null,"Pattaro C","26831199"]
[173,"rs10468017",15,"15q21.3","58386313","LOC101928635"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null,2.8999999999999998E-3," "," ",null," ",null," ",null,"Shin SY","24816252"]
[173,"rs35853021",15,"15q21.3","58388444","LOC102724766","T","Lipid metabolism phenotypes",null,"7,00E-076"," "," "," ",2.7550000000000002E-2," "," ",null,1.0149999999999999E-2," "," ",null," ",null," ",null,"Kettunen J","22286219"]
[173,"rs1532085",15,"15q21.3","58391167","LOC101928635"," ","Metabolite levels",null,null," "," "," ",1.4749999999999999E-2," "," ",null,3.1099999999999999E-2," "," ",null," ",null," ",null,"Inouye M","22916037"]
[173,"rs1532085",15,"15q21.3",58391167,"LOC101928635","A","Lipid metabolism phenotypes",null,"4,00E-016",null,null,null,1.4749999999999999E-2,{"$nulls":11},"Chasman DI",19936222]
[173,"rs2070895",15,"15q21.3","58431740","LIPC, LOC101928635"," ","Blood metabolite levels",null,null," "," "," ",null,2.0389999999999998E-2," ",null," "," "," ",null,4.827E-2,null," ",null,"Shin SY","24816252"]
[173,"rs588136",15,"15q21.3","58438299","LIPC, LOC101928694"," ","Blood metabolite levels",null,null," "," "," ",null,2.8490000000000001E-2," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[173,"rs261342",15,"15q21.3","58438954","LIPC, LOC101928694"," ","Metabolite levels",null,null," "," "," ",null,1.35E-2," ",null," "," "," ",null," ",null," ",null,"Hong, MG","23281178"]
[174,"rs2306786",15,"15q22.2","59195731","MYO1E"," ","Metabolite levels",null,null," "," "," ",null," "," ",null,2.2159999999999999E-2," "," ",null," ",null," ",null,"Inouye M","22916037"]
[175,"rs2652822",15,"15q22.2","63130573","LACTB","T","Metabolic traits",null,"7,00E-027",4.011E-2," "," ",5.0080000000000003E-3,2.362E-3," ",null," "," "," ",null," ",null," ",null,"Suhre K","21886157"]
[175,"rs1472631",15,"15q22.2","63131540","LACTB","A","Blood metabolite levels",null,"2,00E-088",2.2113000000000001E-2," "," ",3.5070000000000001E-3,2.5769999999999999E-3," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[177,"rs2007084",15,"15q26.1","89802104","ANPEP"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[178,"rs2235649",16,"16p13.3","1787405","NUBP2"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null,3.1789999999999999E-2," "," ",null," ",null," ",null,"Shin SY","24816252"]
[179,"rs7200543",16,"16p13.11","15036113","PDXDC1","A","Glycerophospholipid levels","PC aa C38:3 (Glycerophospholipid levels)",3.0000000000000001E-17,1.03E-5," "," ",null,1.0200000000000001E-3," ",null,1.9630000000000002E-2," "," ",null," ",null," ","A: metab ↑; BMI ↑","Draisma HH",26068415]
[179,"rs7200543",16,"16p13.11","15036113","PDXDC1","G","Metabolic traits","1‐eicosatrienoylglycero‐phosphocholine / 1‐linoleoylglycero‐phosphocholine ",5.0000000000000004E-16,null," "," ",null,null," ",null,null," "," ",null," ",null," ","G: metab ↓; BMI ↓","Suhre K","21886157"]
[179,"rs6498540",16,"16p13.11","15036737","PDXDC1","A","Glycerophospholipid levels","dihomo-linolenate (20:3n3 or n6)",null,1.2800000000000001E-3," "," ",null,1.3600000000000001E-3," ",null,1.159E-2," "," ",null," ",null," ",null,"Shin SY","26068415"]
[179,"rs6498540",16,"16p13.11","15036737","PDXDC1","A","Glycerophospholipid levels","lysoPC a C20:3",{"$nulls":16},"Draisma HH",26068415]
[179,"rs2740",16,"16p13.11","15038251","PDXDC1, NTAN1","A","Blood metabolite ratios","linoleate (18:2n6)/ dihomo-linolenate (20:3n3 or n6)",null,4.6600000000000001E-3," "," ",null,1.32E-3," ",null,1.5800000000000002E-2," "," ",null," ",null," ",null,"Shin SY","24816252"]
[179,"rs11075253",16,"16p13.11","15054789","PDXDC1, NTAN1","A","Lipid metabolism phenotypes","Linoleic acid/PUFA",5E-15," ",4.6329999999999999E-5,3.5430000000000003E-2,null," "," ",null," "," ",1.9269999999999999E-2,null,2.1569999999999999E-2,null," ","A: metab ↓; EdAtt ↑","Kettunen J","22286219"]
[179,"rs1629212",16,"16p13.11","15284840","LOC105371097"," ","Glycerophospholipid levels",null,null," ",1.093E-3," ",null," "," ",null," "," "," ",null," ",null," ",null,"Draisma HH","26068415"]
[180,"rs924135",16,"16p13.11","16029602","ABCC1"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null,7.796E-3," "," ",null," ",null," ",null,"Shin SY","24816252"]
[180,"rs2062541",16,"16p13.11","16033378","ABCC1"," ","Blood metabolite ratios",null,null," "," "," ",null," "," ",null,6.6210000000000001E-3," "," ",null," ",null," ",null,"Shin SY","24816252"]
[181,"rs13329952",16,"16p12.3","20355185","UMOD"," ","Glomerular filtration rate (creatinin in serum)",null,null,5.5120000000000004E-3,1.404E-2," ",null,3.5479999999999998E-2," ",null," ",1.5730000000000001E-2," ",null," ",null," ",null,"Pattaro C","26831199"]
[181,"rs12917707",16,"16p12.3","20356368","UMOD - PDILT"," ","Urinary uromodulin levels",null,null,6.0489999999999997E-3,1.55E-2," ",null," "," ",null," ",3.6450000000000003E-2," ",null," ",null," ",null,"Köttgen A, Olden, Pattaro C","20383146, 2683119, 24578125"]
[181,"rs4494548",16,"16p12.3",20360266,"PDILT"," ","Urinary uromodulin levels",null,null," "," "," ",null," "," ",null," "," "," ",null," ",null,4.2620000000000002E-3,"proxy rs9922672","Olden M",24578125]
[181,"rs12446492",16,"16p12.3","20397055","PDILT","A","Urinary uromodulin levels","uromodulin indexed to creatinine",6.0000000000000002E-27,2.9799999999999999E-5," "," ",null," "," ",null," "," "," ",null," ",null," ","A: metab ↓; BMI ↑","Olden",24578125]
[181,"rs1394678",16,"16p12.3","20479736","ACSM2A"," ","Blood metabolite levels",null,null," "," "," ",null,4.4400000000000002E-2," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[181,"rs7499271",16,"16p12.3","20543937","ACSM2B"," ","Serum metabolite levels",null,null," "," "," ",null," "," ",null," "," "," ",null,8.5800000000000008E-3,null," ",null,"Yu B","24625756"]
[181,"rs11645002",16,"16p12.3","20606519","ACSM5P1"," ","Urinary metabolites",null,null," "," "," ",null,4.4859999999999997E-2," ",null," "," "," ",null," ",null," ",null,"Raffler J","26352407"]
[182,"rs4788439",16,"16p12.1",24920477,"ARHGAP17","T","Blood metabolite levels",null,"7,00E-013",null,null,null,2.2120000000000001E-2,{"$nulls":11},"Shin SY",24816252]
[182,"rs4787294",16,"16p12.1",24991029,"ARHGAP17","T","Blood metabolite levels",null,"1,00E-020",null,null,null,2.53E-2,{"$nulls":11},"Shin SY",24816252]
[182,"rs17702912",16,"16p12.1",24991279,"ARHGAP17","T","Urinary metabolites",null,"9,00E-066",null,null,null,2.2450000000000001E-2,{"$nulls":11},"Raffler J",26352407]
[183,"rs1864163",16,"16q13","56963321","CETP"," ","Lipid metabolism phenotypes",null,null," "," "," ",null," "," ",null,9.3329999999999993E-3," "," ",null," ",null," ",null,"Chasman DI","19936222"]
[183,"rs1532624",16,"16q13","56971567","CETP"," ","Lipid metabolism phenotypes",null,null," "," "," ",null," "," ",null,2.8910000000000002E-2,1.2200000000000001E-2," ",null," ",null," ",null,"Chasman DI","19936222"]
[183,"rs7499892",16,"16q13","56972678","CETP"," ","Lipid metabolism phenotypes",null,null," "," "," ",null," "," ",null,8.4440000000000001E-3," "," ",null," ",null," ",null,"Chasman DI","19936222"]
[184,"rs4784054",16,"16q21","58742410","GOT2 - RNU6-1155P"," ","Blood metabolite levels",null,null," "," "," ",null,2.7799999999999998E-2," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[184,"rs12709013",16,"16q21","58795886","LOC107984867"," ","Blood metabolite ratios",null,null," ",2.5430000000000001E-2," ",null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[185,"rs8056893",16,"16q22.1","68270489","SLC7A6","A","Blood metabolite levels","glutaroyl carnitine",2.0000000000000002E-30,3.0549999999999997E-5,1.252E-2,2.2759999999999999E-2,null," "," ",null," "," "," ",null," ",null," ","A: metab ↓; BMI ↓","Shin SY","24816252"]
[185,"rs8056893",16,"16q22.1",68270489,"SLC7A6","A","Blood metabolite levels",null,"2,00E-030",{"$nulls":10},2.8250000000000001E-2,{"$nulls":4},"Shin SY",24816252]
[185,"rs8056893",16,"16q22.1",68270489,"SLC7A6","A","Blood metabolite ratios",null,"3,00E-039",{"$nulls":10},2.8250000000000001E-2,{"$nulls":4},"Shin SY",24816252]
[185,"rs8056893",16,"16q22.1","68270489","SLC7A6","A","Blood metabolite ratios","lysine/ glutaroyl carnitine",3.0000000000000003E-39,{"$nulls":14},"A: metab ↑; BMI ↓","Shin SY",24816252]
[185,"rs6499165",16,"16q22.1","68292297","SLC7A6","A","Metabolic traits","glutaroyl carnitine / lysine",null,3.8299999999999999E-4," ",4.7539999999999999E-2,null," "," ",null," "," "," ",3.7909999999999999E-2," ",2.2540000000000001E-2," ",null,"Suhre K","21886157"]
[185,"rs2863979",16,"16q22.1","68297987","SLC7A6","A","Blood metabolite levels","lysine ",1.0000000000000001E-17,2.7270000000000001E-5,4.462E-2," ",null," "," ",null," "," "," ",1.66E-2," ",4.1889999999999997E-2," ","A: lysine ↑; BMI ↓","Shin SY","24816252"]
[187,"rs217181",16,"16q22.2","72080103","HPR - TXNL4B"," ","Metabolite levels",null,null," ",1.1169999999999999E-2," ",null," "," ",null," "," "," ",null," ",null," ",null,"Inouye M","22916037"]
[187,"rs10500569",16,"16q22.2","72722202","LINC01572 - KRT18P18"," ","Metabolite levels",null,null," "," "," ",null," "," ",null," ",1.1690000000000001E-2," ",null,4.539E-2,null," ",null,"Inouye M","22916037"]
[188,"rs8051149",16,"16q24.2","87845216","SLC7A5","A","Blood metabolite levels",null,8.9999999999999998E-26," "," ",5.4970000000000001E-3,null," "," ",null," "," "," ",null,3.5360000000000003E-2,null," ",null,"Shin SY","24816252"]
[189,"rs164748",16,"16q24.3","89641884","DPEP1 - CHMP1A","C","Glomerular filtration rate in non diabetics (creatinine)","Glomerular filtration rate in non diabetics (creatinine)","2,00E-008"," "," "," ",null,3.835E-4,2.683E-2,null," "," "," ",5.2009999999999999E-3," ",null," ",null,"Pattaro C","26831199"]
[190,"rs12602901",17,"17p13.2","4921330","CHRNE - GP1BA"," ","Blood metabolite levels",null,null," "," ",2.2040000000000001E-2,null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[191,"rs170149",17,"17p13.1","6692611","SLC13A5","A","Blood metabolite levels",null,"1,00E-013"," ",1.494E-2," ",null," "," ",4.573E-2," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[191,"rs2271316",17,"17p13.1","7012082","ALOX12-AS1"," ","Blood metabolite levels",null,null,3.3840000000000002E-2,4.0640000000000003E-2," ",null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[192,"rs2453580",17,"17p11.2","19535008","SLC47A1"," ","Glomerular filtration rate in non diabetics (creatinine)","Glomerular filtration rate in non diabetics (creatinine)","3,00E-013"," "," "," ",null,6.0029999999999997E-3," ",null," "," "," ",4.496E-2," ",null," ",null,"Pattaro C","26831199"]
[193,"rs9916302",17,"17q12","39343696","FBXL20","T","Glomerular filtration rate (creatinin in serum)","eGFRcrea",5E-15," ",1.9040000000000001E-5," ",null,1.2199999999999999E-3," ",null," "," "," ",null," ",null," ","T: eGFRcrea ↓; EdAtt  ↑","Pattaro C","26831199"]
[193,"rs7208487",17,"17q12","39387196","FBXL20","T","Glomerular filtration rate in non diabetics (creatinine)","eGFRcrea",null," ",2.3900000000000002E-3," ",null,4.1050000000000003E-2," ",null," "," "," ",null," ",null," ","T: eGFRcrea ↓; AN ↓?n.s.","Pattaro C","26831199"]
[193,"rs7219014",17,"17q12","39468537","CDK12","A","Urinary_metabolites","histidine/τ-methylhistidine",4.0000000000000002E-26," ",1.075E-5," ",null,2.5799999999999998E-3," ",null," "," "," ",null," ",null," ","A: metab ↓; edAtt ↓","Raffler J","26352407"]
[195,"rs4329",17,"17q23.3","63486097","ACE","G","Metabolic traits",null,"8,00E-020",1.4270000000000001E-3," "," ",3.5739999999999999E-3,1.685E-2," ",null,2.1829999999999999E-2," "," ",null," ",null," ",null,"Suhre K","21886157"]
[195,"rs4343",17,"17q23.3","63488670","ACE"," ","Blood metabolite ratios",null,"1,00E-037",7.5600000000000005E-4," "," ",4.7739999999999996E-3,6.4359999999999999E-3," ",null,2.3050000000000001E-2," "," ",null," ",null," ",null,"Shin SY","24816252"]
[195,"rs4343",17,"17q23.3",63488670,"ACE","A","Serum metabolite levels",null,"8,00E-014",{"$nulls":15},"Yu B",24625756]
[195,"rs4351",17,"17q23.3","63492371","ACE","A","Blood metabolite levels",null,"1,00E-014",1.0039999999999999E-3," "," ",3.14E-3,9.7020000000000006E-3," ",null,1.523E-2," "," ",null," ",null," ",null,"Hong, MG, Shin SY","24816252"]
[195,"rs4362",17,"17q23.3","63496400","ACE","C","Blood metabolite levels",null,"1,00E-021",2.2880000000000001E-3," "," ",2.2429999999999999E-2,2.4510000000000001E-2," ",null,2.1989999999999999E-2," "," ",null," ",null," ",null,"Shin SY","24816252"]
[196,"rs4625783",17,"17q25.3","82128519","CCDC57"," ","Blood metabolite levels",null,null,5.7245000000000004E-3,3.5639999999999998E-2," ",null,3.6209999999999999E-2," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[197,"rs7228085",18,"18q21.1","49634444","LOC105372112"," ","Lipid metabolism phenotypes",null,null," "," ",1.6539999999999999E-2,null," "," ",null," "," "," ",null," ",null," ",null,"Kettunen J","22286219"]
[197,"rs2187375",18,"18q21.1","49645913","LOC105372112"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null," ",4.8300000000000003E-2," ",null," ",null," ",null,"Shin SY","24816252"]
[198,"rs8091180",18,"18q23","79404243","NFATC1"," ","Glomerular filtration rate in non diabetics (creatinine)",null,null,4.5499999999999999E-2," "," ",null," "," ",null," "," "," ",null," ",null," ",null,"Pattaro","26831199"]
[200,"rs2738446",19,"19p13.2","11116650","LDLR","C","Metabolite levels",null,"2,00E-012"," ",1.549E-3," ",null," "," ",4.7019999999999999E-2," "," "," ",null,3.8679999999999999E-3,null," ",null,"Kim YJ","21909109"]
[201,"rs8012",19,"19p13.13","12899706","GCDH, SYCE2"," ","Blood metabolite levels",null,null," "," ",6.1240000000000001E-3,null," ",4.8509999999999998E-2,null," "," "," ",null," ",null,2.9229999999999999E-2,"proxy rs2965216","Shin SY","24816252"]
[202,"rs2108622",19,"19p13.12","15879621","CYP4F2","T","Metabolite levels",null,"9,00E-024"," "," ",4.47E-3,null," ",1.8620000000000001E-2,null," "," "," ",null," ",8.9180000000000006E-3," ",null,"Hong, MG","23281178"]
[203,"rs4808136",19,"19p13.11","18508057","ELL","A","Blood metabolite levels","myo-inositol","5,00E-014"," ",1.207E-3," ",6.3509999999999993E-5,1.506E-2,3.5300000000000002E-3,null," ",2.2669999999999999E-2," ",null," ",null," ","A: metab ↑; Alz ↑","Shin SY","24816252"]
[204,"rs12460876",19,"19q13.11","32865985","SLC7A9"," ","Glomerular filtration rate in non diabetics (creatinine)",null,null," ",4.527E-4," ",null," "," ",null," "," "," ",null," ",null," ",null,"Pattaro C","26831199"]
[204,"rs8101881",19,"19q13.11","32873722","SLC7A9 - CEP89"," ","Blood metabolite levels",null,null," ",5.2780000000000004E-4," ",null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY",24816252]
[205,"rs11666497",19,"19q13.13","37973622","SIPA1L3"," ","Glomerular filtration rate (creatinin in serum)",null,null," ",4.1169999999999998E-2," ",null," "," ",null," "," "," ",null," ",null," ",null,"Pattaro C","26831199"]
[206,"rs4803750",19,"19q13.32",44744370,"BCL3","G","Lipid metabolism phenotypes","LDL-C assay fasting",1E-27,null,null,null,9.0360000000000001E-13,{"$nulls":10},"G: metab  ↓; Alz ↓","Chasman DI","19936222"]
[206,"rs7412",19,"19q13.32",44908822,"APOE","T","Lipid metabolism phenotypes","L-LDL-FC","3,00E-058",null,null,2.307E-2,"1.234e-22",{"$nulls":10},"T: metab ↓; Alz ↓","Kettunen J","22286219"]
[206,"rs445925",19,"19q13.32","44912383","APOE - APOC1"," ","Metabolite levels",null,null," "," ",3.7089999999999998E-2,null," ",9.9570000000000006E-3,null," "," "," ",null," ",null," ",null,"Inouye M, Shin SY","22916037, 24816252"]
[206,"rs4420638",19,"19q13.32","44919689","APOC1 - APOC1P1","A","Lipid traits","LDL-C","1,00E-014",5.0109999999999998E-4," "," ","1.96e-454"," "," ",null," "," "," ",3.5270000000000003E-2," ",null," ","G: metab ↑ Alz: proxy rs56131196","Keller M","24023261"]
[207,"rs182420",19,"19q13.33","47868938","LOC102725176"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null,4.7719999999999999E-2," "," ",null," ",null," ",null,"Shin SY","24816252"]
[207,"rs2547231",19,"19q13.33","47881800","SULT2A1"," ","Blood metabolite ratios",null,null," "," "," ",null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY",24816252]
[207,"rs601338",19,"19q13.33","48703417","LOC105447645, FUT2"," ","Blood metabolite ratios",null,"3E-11, 2E-20",6.9340000000000001E-3,2.3930000000000002E-3," ",null,7.0279999999999995E-4," ",null," "," "," ",3.9330000000000002E-4," ",null," ",null,"Shin SY","24816252"]
[207,"rs602662",19,"19q13.33","48703728","LOC105447645, FUT2","A","Folate pathway vitamin levels","Folate pathway vitamin levels","2,00E-015",1.157E-2,5.8729999999999997E-3,2.7720000000000002E-2,null,9.1449999999999995E-4," ",null," ",3.39E-2,4.2419999999999999E-2,6.9019999999999997E-4," ",null," ",null,"Hazra A","19744961"]
[207,"rs503279",19,"19q13.33","48705753","MAMSTR, FUT2"," ","Metabolic traits",null,null,8.4989999999999996E-3,5.3439999999999998E-3,2.9940000000000001E-2,null,1.4419999999999999E-3," ",null," "," "," ",6.313E-4," ",null," ",null,"Suhre K, Shin SY","21886157, 24816252"]
[207,"rs2287921",19,"19q13.33","48725015","RASIP1","C","Urinary metabolites (H-NMR features)","FUT2 - Fucose","7,00E-019",2.3619999999999999E-2,1.8800000000000001E-2," ",3.7229999999999999E-2,1.139E-3," ",null," "," "," ",3.997E-6," ",null," ","C: metab ↑, BIP ↑ (Rueedi: ?)","Rueedi R","24586186"]
[207,"rs281408",19,"19q13.33","48730149","RASIP1","A","Urinary metabolites (H-NMR features)",null,"4,00E-032",4.2729999999999997E-2,2.861E-2," ",null,5.2009999999999999E-3," ",null," "," "," ",1.5909999999999999E-4," ",null," ",null,"Rueedi R","24586186"]
[208,"rs2280401",19,"19q13.33","49496752","RPS11"," ","Metabolite levels",null,null," "," "," ",null," ",2.882E-3,null," "," "," ",null," ",null," ",null,"KIM, YJ","21909109"]
[210,"rs4814176",20,"20p12.1","12978750","LOC101929486 - SPTLC3"," ","Blood metabolite ratios",null,null," "," "," ",null," ",1.417E-2,null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[210,"rs680379",20,"20p12.1","12988752","LOC101929486 - SPTLC3"," ","Glycerophospholipid levels",null,null," "," "," ",null," ",1.4930000000000001E-2,null," "," "," ",null," ",null," ",null,"Draisma HH","26068415"]
[210,"rs6088580",20,"20q11.22","34697249","PIGU - LOC105372599","C","Glomerular filtration rate (creatinin in serum)","Glomerular filtration rate (creatinin in serum)","2,00E-009",8.0809999999999996E-3,1.2319999999999999E-2," ",null,1.7770000000000001E-2," ",null," "," "," ",2.5730000000000002E-3," ",null," ",null,"Pattaro C","26831199"]
[212,"rs6065904",20,"20q13.12","45906012","PLTP"," ","Lipid metabolism phenotypes",null,null," "," ",4.6859999999999999E-2,null," "," ",null," ",9.9649999999999999E-3," ",null," ",null,8.9269999999999992E-3,null,"Kettunen J","22286219"]
[212,"rs4810479",20,"20q13.12","45916409","PLTP - PCIF1","C","Metabolite levels",null,"2,00E-042"," "," ",1.478E-2,null," "," ",null," ",3.107E-3," ",1.464E-3," ",null," ",null,"Inouye M","22916037"]
[212,"rs6065906",20,"20q13.12","45925376","PLTP - LOC107985388"," ","Lipid metabolism phenotypes",null,null," ",1.6230000000000001E-2,2.5350000000000001E-2,null," "," ",null," ",1.6819999999999999E-3," ",null," ",null,1.524E-2,null,"Chasman DI","19936222"]
[213,"rs17216707",20,"20q13.2",54115823,"BCAS1 - CYP24A1","C","Glomerular filtration rate (creatinin in serum)","Glomerular filtration rate (creatinin in serum)","9,00E-015",null,null,null,3.8370000000000001E-2,{"$nulls":11},"Pattaro C",26831199]
[214,"rs234714",21,"21q22.3","43067923","CBS"," ","Plasma homocysteine levels (post-methionine load test)",null,null," "," ",3.5290000000000002E-2,null," "," ",null," "," "," ",null," ",null," ",null,"William SR","24651765"]
[215,"rs2238732",22,"22q11.21",18927834,"PRODH","T","Amino acid levels",null,"3,00E-039",null,null,null,1.248E-2,{"$nulls":11},"Draisma HH",26068415]
[216,"rs4680",22,"22q11.21","19963748","COMT"," ","Blood metabolite levels",null,null," "," ",4.6989999999999997E-2,null," "," ",null," "," "," ",null," ",null," ",null,"Shin SY","24816252"]
[218,"rs12483959",22,"22q13.31","43930116","PNPLA3"," ","Metabolite levels",null,null," "," "," ",null,9.4149999999999998E-3," ",null,4.342E-2,1.6E-2," ",null," ",null," ",null,"KIM, YJ","21909109"]
[219,"rs131794",22,"22q13.33",50533323,"ODF3B - LOC102724608",null,"Blood metabolite levels",{"$nulls":17},"Shin SY","24816252"]
[219,"rs6151429",22,"22q13.33","50625049","ARSA"," ","Blood metabolite levels",null,null," "," "," ",null," "," ",null," "," ",2.342E-2,null," ",null," ",null,"Shin SY","24816252"]
[]
["Region 1MB: consecutive number of chromosomal regions +/-500 kb"]
["CHR: chromosom"]
["GWAS catalog:  https://www.ebi.ac.uk/gwas/"]
["Effect direction:  Upward arrows indicate positive beta-values or odds ratios >1, downward arrows negative beta-values or odds ratios <1 "]
["bold red values indicate significant results upon correction for 516 tests (p ≤ 9,7 x 10-5)"]