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{"sheet":"Supplementary Table 1","index":0,"n_rows":375,"n_cols":4,"rows_kept":375,"cut":false,"hidden":false,"merged":[]}
["Ingenuity.Canonical.Pathways","P.value","Ratio","Molecules"]
["Sirtuin Signaling Pathway",9.1201083935591004E-5,0.88100000000000001,"NDUFA10,VDAC3,ATP5F1,PGAM1,PRKAA1,NDUFB7,MT-ND3,PPARA,NDUFA5,SDHB,TUBA1A,NDUFA8,ATG3,NDUFA9,ATP5A1,NDUFS7,MAPK12,SOD1,NDUFA2,CPT1B,NDUFAB1,CYC1,SOD2,SOD3,VDAC2,SLC25A4,TUBA1B,TUBA4A,NDUFA11,NDUFS6,PGAM2,PPIF,IDH2,VDAC1,GOT2,NDUFA12,PGK1,PFKM,UQCRFS1,NDUFS8,NDUFV2,MAPK3,SDHA,TIMM10,NDUFV1,PDHA1,NDUFS1,NDUFB10,NDUFS2,NAMPT,LDHA,LDHB"]
["Sertoli Cell-Sertoli Cell Junction Signaling",6.7608297539198197E-4,0.95799999999999996,"MAPK14,VCL,MAPK12,ACTC1,ACTA2,ACTN1,ILK,PRKAR1A,TUBB4A,TUBB2A,TUBA1A,ACTB,ITGB1,ACTN2,TUBA1B,TUBA4A,MAP2K3,ACTA1,Actn3,RAC1,MAPK3,PRKAR2A,SPTAN1"]
["Germ Cell-Sertoli Cell Junction Signaling",1.0964781961431899E-3,0.92900000000000005,"MAPK14,VCL,ACTC1,ACTA2,ILK,TUBB2A,TUBA1A,CFL1,ACTB,ITGB1,GRB2,ACTN2,MAP2K3,MAPK3,MAPK12,ACTN1,CFL2,RHOA,TUBB4A,GSN,TUBA1B,TUBA4A,ACTA1,MAP2K6,Actn3,RAC1"]
["Actin Cytoskeleton Signaling",2.0417379446695302E-3,0.875,"VCL,ACTC1,ACTA2,TLN2,MYH3,CFL1,PFN1,MYH4,MYL1,ACTB,ITGB1,KNG1,GRB2,ACTN2,MYLK2,F2,MAPK3,MYH1,MYH7,TLN1,FLNA,MSN,ACTN1,MYH10,CFL2,RHOA,MYL6,GSN,MYLPF,MYH8,ACTA1,TTN,Actn3,RAC1,PFN2"]
["Mitochondrial Dysfunction",3.0902954325135899E-3,0.83599999999999997,"NDUFA10,VDAC3,VDAC1,COX5A,ATP5F1,OGDH,NDUFA12,NDUFB7,MT-ND3,NDUFA5,PRDX3,SDHB,NDUFA8,COX6B1,TXN2,CAT,GSR,NDUFA9,ATP5A1,UQCRFS1,NDUFS8,NDUFV2,Atp5e,UQCRC1,MT-CO1,PARK7,NDUFS7,MAPK12,SDHA,ACO2,NDUFV1,NDUFA2,CPT1B,PDHA1,NDUFAB1,CYC1,NDUFS1,NDUFB10,SOD2,NDUFS2,VDAC2,NDUFA11,AIFM1,NDUFS6,ATP5H,GPD2"]
["FAK Signaling",3.2359365692962798E-3,1,"EGFR,VCL,TLN1,ACTC1,ACTA2,TLN2,ACTB,ITGB1,GRB2,ACTA1,RAC1,CAPNS1,MAPK3,CAPN2"]
["Oxidative Phosphorylation",3.38844156139202E-3,0.88200000000000001,"NDUFA10,COX5A,ATP5F1,NDUFA12,NDUFB7,MT-ND3,NDUFA5,SDHB,NDUFA8,COX6B1,NDUFA9,ATP5A1,UQCRFS1,NDUFS8,NDUFV2,Atp5e,UQCRC1,MT-CO1,NDUFS7,SDHA,NDUFV1,NDUFA2,NDUFAB1,NDUFS1,NDUFB10,CYC1,NDUFS2,NDUFA11,ATP5H,NDUFS6"]
["Regulation of Cellular Mechanics by Calpain Protease",7.4131024130091802E-3,1,"EGFR,VCL,TLN1,ITGB1,GRB2,ACTN2,ACTN1,TLN2,Actn3,CAPNS1,MAPK3,CAPN2"]
["ILK Signaling",8.9125093813374606E-3,0.84599999999999997,"FLNB,VCL,ACTC1,ACTA2,ILK,MYH3,CFL1,MYH4,MYL1,ACTB,ITGB1,GRB2,ACTN2,PPP2R1A,FLNC,MAPK3,PPP2CA,FERMT2,MYH1,MYH7,FLNA,MAPK12,ACTN1,MYH10,CFL2,RHOA,MYL6,MYH8,ACTA1,MAP2K6,Actn3,ITGB4,NACA"]
["Remodeling of Epithelial Adherens Junctions",9.1201083935591003E-3,0.94099999999999995,"VCL,ACTC1,ACTA2,ACTN1,NME1,TUBB4A,TUBB2A,TUBA1A,RAB7A,CLIP1,ACTB,ACTN2,TUBA1B,TUBA4A,ACTA1,Actn3"]
["Integrin Signaling",1.4791083881682101E-2,0.86199999999999999,"VCL,ACTC1,ACTA2,TLN2,ILK,ITGA7,PFN1,ACTB,ITGB1,GRB2,ACTN2,MYLK2,CAPNS1,MAPK3,CAPN2,TLN1,ACTN1,RHOA,GSN,ACTA1,TTN,Actn3,RAC1,PFN2,ITGB4"]
["Breast Cancer Regulation by Stathmin1",1.6595869074375599E-2,0.9,"CAMK2B,PPP1CA,CAMK2A,PRKAR1A,RHOA,TUBB4A,TUBB2A,TUBA1A,CAMK2G,GRB2,PPP2R1A,TUBA1B,TUBA4A,PPP1R3A,RAC1,MAPK3,PRKAR2A,PPP2CA"]
["Clathrin-mediated Endocytosis Signaling",2.2908676527677699E-2,0.89500000000000002,"TF,CSNK2B,CLTC,ACTC1,ACTA2,AP1B1,RAB7A,HSPA8,ACTB,ITGB1,GRB2,CLTB,ACTA1,RAC1,ITGB4,F2,ALB"]
["Paxillin Signaling",2.2908676527677699E-2,0.89500000000000002,"MAPK14,VCL,TLN1,MAPK12,ACTC1,ACTA2,ACTN1,TLN2,ITGA7,ACTB,ITGB1,GRB2,ACTN2,ACTA1,Actn3,RAC1,ITGB4"]
["Crosstalk between Dendritic Cells and Natural Killer Cells",2.5118864315095801E-2,1,"CAMK2B,TLN1,ACTB,CAMK2G,ACTC1,ACTA2,ACTA1,TLN2,CAMK2A"]
["Amyloid Processing",2.5118864315095801E-2,1,"MAPK14,CSNK2B,MAPK12,MAPT,CAPNS1,PRKAR1A,MAPK3,CAPN2,PRKAR2A"]
["Role of Tissue Factor in Cancer",2.6302679918953801E-2,0.92900000000000005,"EGFR,MAPK14,MAPK12,CFL2,FGG,CFL1,ITGB1,FGB,GRB2,RAC1,F2,MAPK3,P4HB"]
["Caveolar-mediated Endocytosis Signaling",3.7153522909717303E-2,0.92300000000000004,"FLNB,EGFR,FLNA,ACTB,ITGB1,ACTC1,FLNC,ACTA2,ACTA1,ITGB4,ITGA7,ALB"]
["Glycolysis I",3.7153522909717303E-2,0.92300000000000004,"TPI1,ENO3,PGAM1,PGK1,ALDOA,PKM,GAPDH,PFKM,PGAM2,ENO1,GPI,PFKL"]
["HIF1α Signaling",3.8018939632056097E-2,1,"MAPK14,COPS5,MAPK12,LDHA,ELOC,GRB2,MAPK3,LDHB"]
["Chemokine Signaling",3.8018939632056097E-2,1,"CAMK2B,MAPK14,CFL1,CAMK2G,MAPK12,CAMK2A,MAPK3,RHOA"]
["Regulation of Actin-based Motility by Rho",4.2657951880159299E-2,0.88200000000000001,"ACTC1,ACTA2,RHOA,MYL6,CFL1,PFN1,MYL1,GSN,ACTB,ITGB1,MYLPF,ARHGDIA,ACTA1,RAC1,PFN2"]
["Gap Junction Signaling",4.2657951880159299E-2,0.88200000000000001,"EGFR,ACTC1,GJC3,ACTA2,PRKAR1A,TUBB4A,TUBB2A,TUBA1A,ACTB,GRB2,TUBA1B,TUBA4A,ACTA1,MAPK3,PRKAR2A"]
["Amyotrophic Lateral Sclerosis Signaling",5.24807460249773E-2,0.91700000000000004,"GLUL,CAT,SOD1,CACNA1S,GRB2,GPX1,PRPH,RAC1,NEFL,CAPNS1,CAPN2"]
["CDK5 Signaling",5.24807460249773E-2,0.91700000000000004,"MAPK14,ITGB1,MAPK12,PPP1CA,PPP2R1A,MAPT,PPP1R3A,PRKAR1A,MAPK3,PRKAR2A,PPP2CA"]
["Gluconeogenesis I",5.24807460249773E-2,0.91700000000000004,"ENO3,PGAM1,PGK1,ME1,GAPDH,MDH2,ALDOA,PGAM2,ENO1,MDH1,GPI"]
["Acute Phase Response Signaling",5.3703179637025297E-2,0.82099999999999995,"CFB,MAPK14,TF,C3,CP,MAPK12,KLKB1,APOH,SERPINA3,PLG,FGG,SOD2,C4A/C4B,FGB,GRB2,MAP2K3,C9,HPX,AHSG,MAP2K6,F2,ALB,MAPK3"]
["AMPK Signaling",5.6234132519034898E-2,0.83299999999999996,"MAPK14,PPM1B,PRKAA1,MAPK12,CPT1B,EEF2,PRKAR1A,RAB7A,ACTB,GYS1,CKM,GRB2,PPP2R1A,MAP2K3,CPT2,PFKM,PRKAR2A,PFKL,AK1,PPP2CA"]
["LXR/RXR Activation",5.7543993733715701E-2,0.875,"GC,TF,C3,APOH,HADH,CD36,C4A/C4B,VTN,KNG1,C9,HPX,AHSG,ECHS1,ALB"]
["Virus Entry via Endocytic Pathways",5.7543993733715701E-2,0.875,"FLNB,FLNA,CLTC,ACTC1,ACTA2,AP1B1,ACTB,ITGB1,GRB2,FLNC,CLTB,ACTA1,RAC1,ITGB4"]
["Coagulation System",5.7543993733715701E-2,1,"KNG1,FGB,KLKB1,PLG,SERPINC1,F2,FGG"]
["PEDF Signaling",5.7543993733715701E-2,1,"SOD2,MAPK14,MAPK12,GRB2,RAC1,MAPK3,RHOA"]
["PTEN Signaling",5.7543993733715701E-2,1,"EGFR,CSNK2B,ITGB1,GRB2,ILK,RAC1,MAPK3"]
["FGF Signaling",5.7543993733715701E-2,1,"MAPK14,MAPK12,GRB2,MAP2K3,MAP2K6,RAC1,MAPK3"]
["Protein Kinase A Signaling",6.16595001861482E-2,0.78600000000000003,"FLNB,CAMK2B,PYGM,YWHAQ,TNNI2,DUSP3,TNNI1,PYGB,MYH4,MYL1,PGP,RYR1,PHKB,FLNC,MYLK2,MAPK3,PRKAR2A,YWHAG,FLNA,PPP1CA,MYH10,CAMK2A,PRKAR1A,RHOA,MYL6,ACP1,GYS1,MYLPF,CAMK2G,PPP1R3A,PHKG1,TTN,YWHAZ"]
["Epithelial Adherens Junction Signaling",6.3095734448019303E-2,0.80600000000000005,"VCL,ACTC1,ACTA2,TUBB2A,MYH3,TUBA1A,CLIP1,MYH4,MYL1,ACTB,ACTN2,EGFR,MYH1,MYH7,ACTN1,MYH10,RHOA,TUBB4A,MYL6,TUBA1B,TUBA4A,MYH8,ACTA1,Actn3,RAC1"]
["Tight Junction Signaling",6.7608297539198198E-2,0.81499999999999995,"MYH1,MYH7,VCL,ACTC1,YKT6,ACTA2,MYH10,PRKAR1A,RHOA,MYH3,MYL6,MYH4,MYL1,ACTB,PPP2R1A,MYH8,VAPA,ACTA1,RAC1,PRKAR2A,PPP2CA,SPTAN1"]
["Regulation of eIF4 and p70S6K Signaling",7.2443596007499E-2,0.82599999999999996,"RPS27L,EIF3G,MAPK14,MAPK12,RPS5,RPS2,RPS14,RPSA,RPS20,RPS12,RPS3,RPS17,ITGB1,GRB2,PPP2R1A,AGO2,RPS21,MAPK3,PPP2CA"]
["Unfolded protein response",7.4131024130091802E-2,0.90900000000000003,"CALR,HSPA9,HSPA4,HSPA1A/HSPA1B,DNAJA2,HSPA8,CANX,HSPH1,VCP,P4HB"]
["VEGF Signaling",7.4131024130091802E-2,0.90900000000000003,"VCL,ACTB,ACTC1,GRB2,ACTN2,ACTA2,ACTN1,ACTA1,Actn3,MAPK3"]
["Glucocorticoid Receptor Signaling",7.5857757502918399E-2,0.84199999999999997,"HSPA1A/HSPA1B,MAPK14,PRKAA1,MAPK12,JAK3,FKBP4,FGG,ANXA1,HSPA9,HSPA4,HSPA8,ACTB,GRB2,HSP90AB1,RAC1,MAPK3"]
["CTLA4 Signaling in Cytotoxic T Lymphocytes",8.7096358995608095E-2,1,"CLTC,GRB2,PPP2R1A,CLTB,AP1B1,PPP2CA"]
["Semaphorin Signaling in Neurons",8.7096358995608095E-2,1,"CFL1,ITGB1,RAC1,CFL2,MAPK3,RHOA"]
["MSP-RON Signaling Pathway",8.7096358995608095E-2,1,"ACTB,ACTC1,KLKB1,GRB2,ACTA2,ACTA1"]
["Intrinsic Prothrombin Activation Pathway",8.7096358995608095E-2,1,"KNG1,FGB,KLKB1,SERPINC1,F2,FGG"]
["Telomerase Signaling",8.7096358995608095E-2,1,"EGFR,GRB2,PPP2R1A,HSP90AB1,MAPK3,PPP2CA"]
["Glutaryl-CoA Degradation",8.7096358995608095E-2,1,"PARK7,HSD17B4,ACAT1,HADHA,HADH,HADHB"]
["Tryptophan Degradation III (Eukaryotic)",8.7096358995608095E-2,1,"PARK7,HSD17B4,ACAT1,HADHA,HADH,HADHB"]
["RhoA Signaling",9.7723722095581098E-2,0.83299999999999996,"ACTC1,MSN,ACTA2,CFL2,RHOA,MYL6,CFL1,PFN1,MYL1,ACTB,MYLPF,ACTA1,TTN,PFN2,MYLK2"]
["Glioma Signaling",0.102329299228075,0.9,"CAMK2B,EGFR,CAMK2G,GRB2,IDH3G,IDH1,CAMK2A,IDH2,MAPK3"]
["HIPPO signaling",0.102329299228075,0.9,"YWHAQ,YWHAG,NF2,PPP1CA,PPP2R1A,CUL1,PPP1R3A,YWHAZ,PPP2CA"]
["TCA Cycle II (Eukaryotic)",0.103038612044162,0.85699999999999998,"IDH3A,SDHB,DLD,OGDH,SDHA,CS,IDH3G,ACO2,MDH2,SUCLA2,SUCLG1,MDH1"]
["PI3K/AKT Signaling",0.103038612044162,0.85699999999999998,"YWHAQ,YWHAG,GYS1,ITGB1,JAK3,GRB2,PPP2R1A,HSP90AB1,ILK,YWHAZ,MAPK3,PPP2CA"]
["RhoGDI Signaling",0.117489755493953,0.81,"CDH13,GDI1,ACTC1,MSN,GDI2,ACTA2,CFL2,RHOA,MYL6,CFL1,MYL1,ACTB,ITGB1,MYLPF,ARHGDIA,ACTA1,RAC1"]
["IL-15 Signaling",0.13061708881318401,1,"MAPK14,MAPK12,JAK3,GRB2,MAPK3"]
["iCOS-iCOSL Signaling in T Helper Cells",0.13061708881318401,1,"CAMK2B,CAMK2G,GRB2,RAC1,CAMK2A"]
["Ovarian Cancer Signaling",0.13061708881318401,1,"EGFR,GRB2,PRKAR1A,MAPK3,PRKAR2A"]
["Glioma Invasiveness Signaling",0.13061708881318401,1,"VTN,GRB2,PLG,MAPK3,RHOA"]
["Mouse Embryonic Stem Cell Pluripotency",0.13061708881318401,1,"MAPK14,MAPK12,JAK3,GRB2,MAPK3"]
["Ephrin A Signaling",0.13061708881318401,1,"CFL1,GRB2,RAC1,CFL2,RHOA"]
["Isoleucine Degradation I",0.13061708881318401,1,"DLD,ACAT1,HADHA,ECHS1,HADHB"]
["GM-CSF Signaling",0.13061708881318401,1,"CAMK2B,CAMK2G,GRB2,CAMK2A,MAPK3"]
["mTOR Signaling",0.133967668742593,0.79200000000000004,"RPS27L,EIF3G,PRKAA1,EIF4B,RPS5,RPS2,RPS14,RPSA,RPS20,RHOA,RPS12,RPS3,RPS17,GRB2,PPP2R1A,RPS21,RAC1,MAPK3,PPP2CA"]
["Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes",0.14125375446227501,0.88900000000000001,"TLN1,ACTB,ACTC1,ACTA2,ACTA1,TLN2,RAC1,MAPK3"]
["HMGB1 Signaling",0.14125375446227501,0.88900000000000001,"MAPK14,MAPK12,GRB2,MAP2K3,MAP2K6,RAC1,MAPK3,RHOA"]
["Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis",0.14125375446227501,0.88900000000000001,"MAPK14,GSN,ITGB1,MAPK12,GRB2,MAP2K3,MAP2K6,MAPK3"]
["Insulin Receptor Signaling",0.14125375446227501,0.88900000000000001,"ASIC1,GYS1,PPP1CA,GRB2,PPP1R3A,PRKAR1A,MAPK3,PRKAR2A"]
["IGF-1 Signaling",0.14125375446227501,0.88900000000000001,"YWHAQ,YWHAG,CSNK2B,GRB2,YWHAZ,PRKAR1A,MAPK3,PRKAR2A"]
["IL-6 Signaling",0.14125375446227501,0.88900000000000001,"MAPK14,CSNK2B,HSPB7,MAPK12,GRB2,MAP2K3,MAP2K6,MAPK3"]
["Neuroinflammation Signaling Pathway",0.14125375446227501,0.88900000000000001,"SOD2,GLUL,MAPK14,MAPK12,JAK3,GRB2,MAPT,MAPK3"]
["PPARα/RXRα Activation",0.14791083881682099,0.8,"MAPK14,PRKAA1,GOT2,PPARA,GPD1,ACAA1,CPT1B,PRKAR1A,CD36,GRB2,MAP2K3,HSP90AB1,MAP2K6,MAPK3,PRKAR2A,GPD2"]
["GNRH Signaling",0.14791083881682099,0.8,"CAMK2B,EGFR,MAPK14,MAPK12,CACNA1S,CAMK2A,PRKAR1A,CACNB1,CAMK2G,CACNA2D1,GRB2,MAP2K3,MAP2K6,RAC1,MAPK3,PRKAR2A"]
["ERK/MAPK Signaling",0.14791083881682099,0.8,"YWHAQ,YWHAG,TLN1,PPP1CA,TLN2,PRKAR1A,HSPB7,ITGB1,GRB2,PPP2R1A,PPP1R3A,YWHAZ,RAC1,MAPK3,PRKAR2A,PPP2CA"]
["FXR/RXR Activation",0.16292960326397199,0.81200000000000006,"GC,TF,C3,MAPK12,PPARA,APOH,C4A/C4B,VTN,KNG1,C9,HPX,AHSG,ALB"]
["Calcium Signaling",0.16443717232149299,0.75,"CAMK2B,TNNC2,ATP2A3,TNNI2,ACTC1,ATP2A1,CACNA1S,TNNI1,ACTA2,MYH3,TRDN,CACNB1,MYH4,MYL1,RYR1,Tpm1,Tpm2,MAPK3,PRKAR2A,MYH1,MYH7,MYH10,CAMK2A,PRKAR1A,CALR,MYL6,CAMK2G,CACNA2D1,MYH8,ACTA1"]
["Agrin Interactions at Neuromuscular Junction",0.17864875748520501,0.83299999999999996,"EGFR,ACTB,ITGB1,MAPK12,ACTC1,ACTA2,ACTA1,RAC1,MAPK3,LAMA2"]
["EIF2 Signaling",0.18323144223712101,0.75,"RPS27L,EIF3G,EIF5B,ACTC1,ACTA2,RPL23,RPS5,RPS20,RPL12,RPL5,ACTB,GRB2,AGO2,WARS,RPS21,RPL14,RPL18A,MAPK3,RPL30,PPP1CA,RPS2,RPS14,RPSA,RPS12,RPS3,RPS17,ACTA1"]
["CD40 Signaling",0.193196831701692,0.875,"MAPK14,MAPK12,JAK3,GRB2,MAP2K3,MAP2K6,MAPK3"]
["Regulation of the Epithelial-Mesenchymal Transition Pathway",0.193196831701692,0.875,"EGFR,JAK3,GRB2,MAP2K3,MAP2K6,MAPK3,RHOA"]
["Dopamine Receptor Signaling",0.193196831701692,0.875,"PPP1CA,PPP2R1A,PPP1R3A,QDPR,PRKAR1A,PRKAR2A,PPP2CA"]
["G-Protein Coupled Receptor Signaling",0.193196831701692,0.875,"CAMK2B,CAMK2G,GRB2,CAMK2A,PRKAR1A,MAPK3,PRKAR2A"]
["Melanocyte Development and Pigmentation Signaling",0.196336027683605,1,"GRB2,PRKAR1A,MAPK3,PRKAR2A"]
["Estrogen-Dependent Breast Cancer Signaling",0.196336027683605,1,"EGFR,HSD17B4,GRB2,MAPK3"]
["Extrinsic Prothrombin Activation Pathway",0.196336027683605,1,"FGB,SERPINC1,F2,FGG"]
["Actin Nucleation by ARP-WASP Complex",0.196336027683605,1,"ITGB1,GRB2,RAC1,RHOA"]
["Acetyl-CoA Biosynthesis I (Pyruvate Dehydrogenase Complex)",0.196336027683605,1,"PDHB,DLAT,DLD,PDHA1"]
["Superoxide Radicals Degradation",0.196336027683605,1,"SOD2,SOD3,CAT,SOD1"]
["Colanic Acid Building Blocks Biosynthesis",0.196336027683605,1,"MPI,PMM2,UGP2,GPI"]
["Aspartate Degradation II",0.196336027683605,1,"GOT2,MDH2,GOT1,MDH1"]
["IL-2 Signaling",0.196336027683605,1,"CSNK2B,JAK3,GRB2,MAPK3"]
["PPAR Signaling",0.196336027683605,1,"GRB2,PPARA,HSP90AB1,MAPK3"]
["Colorectal Cancer Metastasis Signaling",0.231739464996848,0.81799999999999995,"EGFR,MAPK12,JAK3,GRB2,RAC1,PRKAR1A,MAPK3,PRKAR2A,RHOA"]
["tRNA Charging",0.231739464996848,0.81799999999999995,"NARS,EPRS,CARS,LARS,RARS,VARS,IARS,WARS,IARS2"]
["Superpathway of Inositol Phosphate Compounds",0.231739464996848,0.81799999999999995,"DUSP28,EGFR,NUDT3,ACP1,ATP1A1,PPP1CA,GRB2,CA3,DUSP13"]
["3-phosphoinositide Biosynthesis",0.231739464996848,0.81799999999999995,"DUSP28,EGFR,NUDT3,ACP1,ATP1A1,PPP1CA,GRB2,CA3,DUSP13"]
["p70S6K Signaling",0.25822601906345999,0.78600000000000003,"EGFR,YWHAQ,YWHAG,GRB2,PPP2R1A,MAPT,YWHAZ,EEF2,F2,MAPK3,PPP2CA"]
["Neuregulin Signaling",0.261818300821899,0.85699999999999998,"EGFR,ITGB1,DCN,GRB2,HSP90AB1,MAPK3"]
["IL-17 Signaling",0.261818300821899,0.85699999999999998,"MAPK14,MAPK12,GRB2,MAP2K3,MAP2K6,MAPK3"]
["Pancreatic Adenocarcinoma Signaling",0.261818300821899,0.85699999999999998,"EGFR,MAPK12,JAK3,GRB2,RAC1,MAPK3"]
["RANK Signaling in Osteoclasts",0.261818300821899,0.85699999999999998,"MAPK14,GSN,MAPK12,GRB2,MAP2K6,MAPK3"]
["PI3K Signaling in B Lymphocytes",0.261818300821899,0.85699999999999998,"CAMK2B,C3,CAMK2G,RAC1,CAMK2A,MAPK3"]
["Role of IL-17A in Arthritis",0.261818300821899,0.85699999999999998,"MAPK14,MAPK12,GRB2,MAP2K3,MAP2K6,MAPK3"]
["Valine Degradation I",0.261818300821899,0.85699999999999998,"BCKDHA,DLD,ALDH6A1,HADHA,ECHS1,HADHB"]
["EGF Signaling",0.261818300821899,0.85699999999999998,"EGFR,MAPK14,CSNK2B,MAPK12,GRB2,MAPK3"]
["cAMP-mediated signaling",0.261818300821899,0.85699999999999998,"CAMK2B,CAMK2G,CAMK2A,PRKAR1A,MAPK3,PRKAR2A"]
["p38 MAPK Signaling",0.261818300821899,0.85699999999999998,"MAPK14,HSPB7,MAPK12,MAP2K3,MAPT,MAP2K6"]
["TGF-β Signaling",0.261818300821899,0.85699999999999998,"MAPK14,MAPK12,GRB2,MAP2K3,MAP2K6,MAPK3"]
["PDGF Signaling",0.261818300821899,0.85699999999999998,"CAV3,ACP1,CSNK2B,JAK3,GRB2,MAPK3"]
["BMP signaling pathway",0.261818300821899,0.85699999999999998,"MAPK14,MAPK12,GRB2,PRKAR1A,MAPK3,PRKAR2A"]
["Sumoylation Pathway",0.261818300821899,0.85699999999999998,"GDI1,UBA2,MAPK12,ARHGDIA,GDI2,RHOA"]
["Osteoarthritis Pathway",0.261818300821899,0.85699999999999998,"NAMPT,ITGB1,PRKAA1,DCN,ANXA2,RAC1"]
["IL-7 Signaling Pathway",0.261818300821899,0.85699999999999998,"MAPK14,MAPK12,JAK3,GRB2,IGHM,MAPK3"]
["B Cell Receptor Signaling",0.27797132677592901,0.76500000000000001,"CAMK2B,MAPK14,MAPK12,CAMK2A,CFL2,CFL1,CAMK2G,GRB2,IGHM,MAP2K3,MAP2K6,RAC1,MAPK3"]
["Axonal Guidance Signaling",0.28054336379517097,0.73299999999999998,"CFL2,PRKAR1A,RHOA,TUBB2A,TUBB4A,MYL6,TUBA1A,CFL1,PFN1,COPS5,AFG3L2,MYL1,ITGB1,MYLPF,GRB2,TUBA1B,TUBA4A,RAC1,PFN2,ADAM28,MAPK3,PRKAR2A"]
["Xenobiotic Metabolism Signaling",0.28054336379517097,0.73299999999999998,"CAMK2B,MAPK14,MAPK12,ALDH6A1,GSTM3,CES1,ESD,CAMK2A,ALDH4A1,SOD3,GSTM1,GSTM5,CAT,CAMK2G,GRB2,PPP2R1A,ALDH2,MAP2K3,HSP90AB1,MAP2K6,MAPK3,PPP2CA"]
["Molecular Mechanisms of Cancer",0.29376496519615303,0.75,"CAMK2B,MAPK14,MAPK12,JAK3,CAMK2A,PRKAR1A,RHOA,ITGB1,CAMK2G,GRB2,MAP2K3,MAP2K6,RAC1,MAPK3,PRKAR2A"]
["Role of PKR in Interferon Induction and Antiviral Response",0.29512092266663897,1,"MAPK14,MAP2K3,MAP2K6"]
["TREM1 Signaling",0.29512092266663897,1,"ITGB1,GRB2,MAPK3"]
["Oncostatin M Signaling",0.29512092266663897,1,"JAK3,GRB2,MAPK3"]
["Mitotic Roles of Polo-Like Kinase",0.29512092266663897,1,"PPP2R1A,HSP90AB1,PPP2CA"]
["Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency",0.29512092266663897,1,"JAK3,GRB2,MAPK3"]
["Prostate Cancer Signaling",0.29512092266663897,1,"GRB2,HSP90AB1,MAPK3"]
["Endometrial Cancer Signaling",0.29512092266663897,1,"GRB2,ILK,MAPK3"]
["Non-Small Cell Lung Cancer Signaling",0.29512092266663897,1,"EGFR,GRB2,MAPK3"]
["Hereditary Breast Cancer Signaling",0.29512092266663897,1,"ACTB,GRB2,NPM1"]
["Cyclins and Cell Cycle Regulation",0.29512092266663897,1,"PPP2R1A,CUL1,PPP2CA"]
["IL-17A Signaling in Fibroblasts",0.29512092266663897,1,"MAPK14,MAPK12,MAPK3"]
["Role of JAK1 and JAK3 in γc Cytokine Signaling",0.29512092266663897,1,"JAK3,GRB2,MAPK3"]
["iNOS Signaling",0.29512092266663897,1,"MAPK14,MAPK12,JAK3"]
["ErbB2-ErbB3 Signaling",0.29512092266663897,1,"JAK3,GRB2,MAPK3"]
["Pyrimidine Ribonucleotides De Novo Biosynthesis",0.29512092266663897,1,"NME1,AK1,ANXA1"]
["Glycogen Degradation III",0.29512092266663897,1,"PYGM,PGM1,PYGB"]
["Glycogen Degradation II",0.29512092266663897,1,"PYGM,PGM1,PYGB"]
["Mevalonate Pathway I",0.29512092266663897,1,"ACAT1,HADHA,HADHB"]
["Phenylalanine Degradation IV (Mammalian, via Side Chain)",0.29512092266663897,1,"GOT2,ALDH2,GOT1"]
["Pyrimidine Ribonucleotides Interconversion",0.29512092266663897,1,"NME1,AK1,ANXA1"]
["2-oxobutanoate Degradation I",0.29512092266663897,1,"DLD,PCCA,PCCB"]
["Glycerol-3-phosphate Shuttle",0.29512092266663897,1,"GPD1L,GPD1,GPD2"]
["Rapoport-Luebering Glycolytic Shunt",0.29512092266663897,1,"PGAM1,PGAM2,TIGAR"]
["Superpathway of Geranylgeranyldiphosphate Biosynthesis I (via Mevalonate)",0.29512092266663897,1,"ACAT1,HADHA,HADHB"]
["GDP-mannose Biosynthesis",0.29512092266663897,1,"MPI,PMM2,GPI"]
["Superpathway of Cholesterol Biosynthesis",0.29512092266663897,1,"ACAT1,HADHA,HADHB"]
["Role of p14/p19ARF in Tumor Suppression",0.29512092266663897,1,"GRB2,RAC1,NPM1"]
["JAK/Stat Signaling",0.29512092266663897,1,"JAK3,GRB2,MAPK3"]
["Th1 and Th2 Activation Pathway",0.29512092266663897,1,"JAK3,GRB2,MAP2K6"]
["Th1 Pathway",0.29512092266663897,1,"JAK3,GRB2,MAP2K6"]
["α-Adrenergic Signaling",0.297166603173803,0.8,"PYGM,PYGB,GYS1,PHKB,PHKG1,PRKAR1A,MAPK3,PRKAR2A"]
["CCR3 Signaling in Eosinophils",0.297166603173803,0.8,"MAPK14,CFL1,MAPK12,GRB2,RAC1,CFL2,MAPK3,RHOA"]
["Cholecystokinin/Gastrin-mediated Signaling",0.297166603173803,0.8,"EGFR,MAPK14,MAPK12,GRB2,MAP2K3,MAP2K6,MAPK3,RHOA"]
["Opioid Signaling Pathway",0.30619634336906798,0.73899999999999999,"CAMK2B,CLTC,MAPK12,CACNA1S,CAMK2A,PRKAR1A,AP1B1,CACNB1,RYR1,CAMK2G,CACNA2D1,MAP2K3,CLTB,MAP2K6,RAC1,MAPK3,PRKAR2A"]
["Signaling by Rho Family GTPases",0.316227766016838,0.73099999999999998,"CDH13,MAPK12,ACTC1,MSN,DES,ACTA2,CFL2,RHOA,MYL6,CFL1,CLIP1,MYL1,ACTB,ITGB1,MYLPF,GRB2,ACTA1,RAC1,MAPK3"]
["PAK Signaling",0.31988951096913998,0.76900000000000002,"MYL6,CFL1,MYL1,MAPK12,ITGB1,MYLPF,GRB2,RAC1,CFL2,MAPK3"]
["eNOS Signaling",0.31988951096913998,0.76900000000000002,"HSPA1A/HSPA1B,HSPA9,HSPA4,HSPA8,PRKAA1,KNG1,GRB2,HSP90AB1,PRKAR1A,PRKAR2A"]
["Nitric Oxide Signaling in the Cardiovascular System",0.31988951096913998,0.76900000000000002,"ATP2A3,PRKAA1,KNG1,ATP2A1,CACNA1S,GRB2,HSP90AB1,PRKAR1A,MAPK3,PRKAR2A"]
["Aldosterone Signaling in Epithelial Cells",0.33651156937549098,0.75,"ASIC1,HSPA1A/HSPA1B,HSPA9,HSPA4,HSPB7,HSPA8,HSPD1,GRB2,HSPH1,HSP90AB1,AHCY,MAPK3"]
["NRF2-mediated Oxidative Stress Response",0.34514373933585601,0.71099999999999997,"MAPK14,ACTC1,ACTA2,STIP1,GSTM1,CCT7,ACTB,GSTM5,CAT,GSR,GRB2,MAP2K3,MAPK3,USP14,CBR1,TXN,SOD1,GSTM3,TXNRD1,SOD2,SOD3,DNAJA2,AKR1A1,ACTA1,VCP,MAP2K6,FTH1"]
["Production of Nitric Oxide and Reactive Oxygen Species in Macrophages",0.34833731503601201,0.73699999999999999,"MAPK14,MAPK12,JAK3,PPP1CA,PPARA,RHOA,CAT,GRB2,PPP2R1A,PPP1R3A,RAC1,ALB,MAPK3,PPP2CA"]
["Ceramide Signaling",0.34994516702835698,0.83299999999999996,"GRB2,PPP2R1A,CTSD,MAPK3,PPP2CA"]
["Type I Diabetes Mellitus Signaling",0.34994516702835698,0.83299999999999996,"MAPK14,MAPK12,HSPD1,MAP2K3,MAP2K6"]
["IL-17A Signaling in Airway Cells",0.34994516702835698,0.83299999999999996,"MAPK14,MAPK12,JAK3,GRB2,MAPK3"]
["Ethanol Degradation II",0.34994516702835698,0.83299999999999996,"ACSL1,ALDH2,ADH5,AKR1A1,ALDH4A1"]
["STAT3 Pathway",0.34994516702835698,0.83299999999999996,"EGFR,MAPK14,MAPK12,RAC1,MAPK3"]
["PCP pathway",0.34994516702835698,0.83299999999999996,"PFN1,MAPK12,RAC1,PFN2,RHOA"]
["Toll-like Receptor Signaling",0.34994516702835698,0.83299999999999996,"MAPK14,MAPK12,PPARA,MAP2K3,MAP2K6"]
["Macropinocytosis Signaling",0.34994516702835698,0.83299999999999996,"ITGB1,GRB2,RAC1,ITGB4,RHOA"]
["LPS-stimulated MAPK Signaling",0.37497300224548402,0.77800000000000002,"MAPK14,MAPK12,GRB2,MAP2K3,MAP2K6,RAC1,MAPK3"]
["Neuropathic Pain Signaling In Dorsal Horn Neurons",0.37497300224548402,0.77800000000000002,"CAMK2B,CAMK2G,GRB2,CAMK2A,PRKAR1A,MAPK3,PRKAR2A"]
["Renin-Angiotensin Signaling",0.37497300224548402,0.77800000000000002,"MAPK14,MAPK12,GRB2,RAC1,PRKAR1A,MAPK3,PRKAR2A"]
["Rac Signaling",0.37497300224548402,0.77800000000000002,"CFL1,ITGB1,GRB2,RAC1,CFL2,MAPK3,RHOA"]
["ErbB Signaling",0.37497300224548402,0.77800000000000002,"EGFR,MAPK14,MAPK12,GRB2,MAP2K3,MAP2K6,MAPK3"]
["Netrin Signaling",0.37497300224548402,0.77800000000000002,"CACNB1,RYR1,CACNA2D1,CACNA1S,RAC1,PRKAR1A,PRKAR2A"]
["D-myo-inositol-5-phosphate Metabolism",0.37497300224548402,0.77800000000000002,"DUSP28,NUDT3,ACP1,ATP1A1,PPP1CA,CA3,DUSP13"]
["D-myo-inositol (1,4,5,6)-Tetrakisphosphate Biosynthesis",0.37497300224548402,0.77800000000000002,"DUSP28,NUDT3,ACP1,ATP1A1,PPP1CA,CA3,DUSP13"]
["D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis",0.37497300224548402,0.77800000000000002,"DUSP28,NUDT3,ACP1,ATP1A1,PPP1CA,CA3,DUSP13"]
["3-phosphoinositide Degradation",0.37497300224548402,0.77800000000000002,"DUSP28,NUDT3,ACP1,ATP1A1,PPP1CA,CA3,DUSP13"]
["Salvage Pathways of Pyrimidine Ribonucleotides",0.37497300224548402,0.77800000000000002,"APOBEC2,PRKAA1,MAP2K3,NME1,MAP2K6,MAPK3,AK1"]
["Superpathway of Methionine Degradation",0.37497300224548402,0.77800000000000002,"DLD,GOT2,PCCA,PCCB,GOT1,MAT2A,AHCY"]
["Melatonin Signaling",0.390840895792402,0.75,"CAMK2B,CAMK2G,MAP2K3,MAP2K6,RORB,CAMK2A,PRKAR1A,MAPK3,PRKAR2A"]
["Neuroprotective Role of THOP1 in Alzheimer's Disease",0.390840895792402,0.75,"KNG1,SERPINA3,LONP1,MAPT,CFD,PLG,PRKAR1A,PRKAR2A,CMA1"]
["PKCθ Signaling in T Lymphocytes",0.390840895792402,0.75,"CAMK2B,CACNB1,CAMK2G,CACNA2D1,CACNA1S,GRB2,RAC1,CAMK2A,MAPK3"]
["Cardiac β-adrenergic Signaling",0.390840895792402,0.75,"ATP2A3,PPP1CA,ATP2A1,CACNA1S,PPP2R1A,PPP1R3A,PRKAR1A,PRKAR2A,PPP2CA"]
["Thrombin Signaling",0.40926065973001102,0.72199999999999998,"CAMK2B,EGFR,MAPK14,MAPK12,CAMK2A,RHOA,MYL6,MYL1,MYLPF,CAMK2G,GRB2,F2,MAPK3"]
["Lymphotoxin β Receptor Signaling",0.44360864393143301,1,"GRB2,MAPK3"]
["IL-9 Signaling",0.44360864393143301,1,"JAK3,GRB2"]
["CNTF Signaling",0.44360864393143301,1,"GRB2,MAPK3"]
["Cell Cycle Regulation by BTG Family Proteins",0.44360864393143301,1,"PPP2R1A,PPP2CA"]
["Role of CHK Proteins in Cell Cycle Checkpoint Control",0.44360864393143301,1,"PPP2R1A,PPP2CA"]
["Melanoma Signaling",0.44360864393143301,1,"GRB2,MAPK3"]
["Bladder Cancer Signaling",0.44360864393143301,1,"EGFR,MAPK3"]
["Chronic Myeloid Leukemia Signaling",0.44360864393143301,1,"GRB2,MAPK3"]
["Role of PI3K/AKT Signaling in the Pathogenesis of Influenza",0.44360864393143301,1,"GRB2,MAPK3"]
["MIF-mediated Glucocorticoid Regulation",0.44360864393143301,1,"MIF,MAPK3"]
["Glucose and Glucose-1-phosphate Degradation",0.44360864393143301,1,"PGM1,HK2"]
["Pyruvate Fermentation to Lactate",0.44360864393143301,1,"LDHA,LDHB"]
["Sucrose Degradation V (Mammalian)",0.44360864393143301,1,"TPI1,ALDOA"]
["NADH Repair",0.44360864393143301,1,"NAXE,GAPDH"]
["Pyrimidine Deoxyribonucleotides De Novo Biosynthesis I",0.44360864393143301,1,"NME1,AK1"]
["Methylglyoxal Degradation I",0.44360864393143301,1,"GLO1,HAGH"]
["Branched-chain α-keto acid Dehydrogenase Complex",0.44360864393143301,1,"BCKDHA,DLD"]
["Eumelanin Biosynthesis",0.44360864393143301,1,"DDT,MIF"]
["Glycerol Degradation I",0.44360864393143301,1,"GPD1,GPD2"]
["Methylmalonyl Pathway",0.44360864393143301,1,"PCCA,PCCB"]
["Glycine Cleavage Complex",0.44360864393143301,1,"GCSH,DLD"]
["Retinol Biosynthesis",0.44360864393143301,1,"CES1,ESD"]
["4-hydroxyproline Degradation I",0.44360864393143301,1,"GOT2,ALDH4A1"]
["Arginine Degradation I (Arginase Pathway)",0.44360864393143301,1,"OAT,ALDH4A1"]
["GDP-glucose Biosynthesis",0.44360864393143301,1,"PGM1,HK2"]
["L-cysteine Degradation I",0.44360864393143301,1,"GOT2,GOT1"]
["Formaldehyde Oxidation II (Glutathione-dependent)",0.44360864393143301,1,"ADH5,ESD"]
["UDP-N-acetyl-D-galactosamine Biosynthesis II",0.44360864393143301,1,"HK2,GPI"]
["Glutamate Degradation II",0.44360864393143301,1,"GOT2,GOT1"]
["Aspartate Biosynthesis",0.44360864393143301,1,"GOT2,GOT1"]
["Cell Cycle: G1/S Checkpoint Regulation",0.44360864393143301,1,"RPL5,CUL1"]
["IL-4 Signaling",0.44360864393143301,1,"JAK3,GRB2"]
["Phototransduction Pathway",0.44360864393143301,1,"PRKAR1A,PRKAR2A"]
["Sonic Hedgehog Signaling",0.44360864393143301,1,"PRKAR1A,PRKAR2A"]
["Th2 Pathway",0.44360864393143301,1,"JAK3,GRB2"]
["IL-10 Signaling",0.46025657358135602,0.8,"MAPK14,MAPK12,MAP2K3,MAP2K6"]
["p53 Signaling",0.46025657358135602,0.8,"MAPK14,GRB2,ST13,TIGAR"]
["PXR/RXR Activation",0.46025657358135602,0.8,"GSTM1,PPARA,PRKAR1A,PRKAR2A"]
["Lipid Antigen Presentation by CD1",0.46025657358135602,0.8,"CALR,PSAP,CANX,AP1B1"]
["ATM Signaling",0.46025657358135602,0.8,"MAPK14,MAPK12,PPP2R1A,PPP2CA"]
["ERK5 Signaling",0.46025657358135602,0.8,"EGFR,YWHAQ,YWHAG,YWHAZ"]
["Sphingosine-1-phosphate Signaling",0.46025657358135602,0.8,"GRB2,RAC1,MAPK3,RHOA"]
["HER-2 Signaling in Breast Cancer",0.46025657358135602,0.8,"EGFR,ITGB1,GRB2,ITGB4"]
["Leptin Signaling in Obesity",0.46025657358135602,0.8,"GRB2,PRKAR1A,MAPK3,PRKAR2A"]
["Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes",0.46025657358135602,0.8,"MAPK12,GRB2,RAC1,MAPK3"]
["IL-17A Signaling in Gastric Cells",0.46025657358135602,0.8,"EGFR,MAPK14,MAPK12,MAPK3"]
["nNOS Signaling in Neurons",0.46025657358135602,0.8,"PFKM,CAMK2A,CAPNS1,CAPN2"]
["Ketogenesis",0.46025657358135602,0.8,"ACAT1,HMGCL,HADHA,HADHB"]
["Serotonin Degradation",0.46025657358135602,0.8,"ALDH2,ADH5,AKR1A1,ALDH4A1"]
["Ketolysis",0.46025657358135602,0.8,"ACAT1,HADHA,OXCT1,HADHB"]
["Noradrenaline and Adrenaline Degradation",0.46025657358135602,0.8,"ALDH2,ADH5,AKR1A1,ALDH4A1"]
["Ethanol Degradation IV",0.46025657358135602,0.8,"ACSL1,CAT,ALDH2,ALDH4A1"]
["Neurotrophin/TRK Signaling",0.46025657358135602,0.8,"GRB2,MAP2K3,MAP2K6,MAPK3"]
["IL-1 Signaling",0.466659380314289,0.75,"MAPK14,MAPK12,MAP2K3,MAP2K6,PRKAR1A,PRKAR2A"]
["Glioblastoma Multiforme Signaling",0.466659380314289,0.75,"EGFR,NF2,GRB2,RAC1,MAPK3,RHOA"]
["nNOS Signaling in Skeletal Muscle Cells",0.466659380314289,0.75,"CACNB1,RYR1,CACNA2D1,CACNA1S,DMD,SNTA1"]
["Ephrin B Signaling",0.466659380314289,0.75,"CFL1,ACP1,RAC1,CFL2,MAPK3,RHOA"]
["Gustation Pathway",0.466659380314289,0.75,"ASIC1,CACNB1,CACNA2D1,CACNA1S,PRKAR1A,PRKAR2A"]
["Complement System",0.470977326396953,0.72699999999999998,"CFB,C4A/C4B,CFI,C3,C1QBP,C9,CFD,CFH"]
["Ephrin Receptor Signaling",0.470977326396953,0.72699999999999998,"CFL1,ACP1,ITGB1,GRB2,RAC1,CFL2,MAPK3,RHOA"]
["14-3-3-mediated Signaling",0.47533522594280497,0.70599999999999996,"TUBB4A,TUBB2A,YWHAQ,TUBA1A,YWHAG,MAPK12,GRB2,TUBA1B,TUBA4A,MAPT,YWHAZ,MAPK3"]
["Role of NFAT in Cardiac Hypertrophy",0.47752927365769099,0.7,"CAMK2B,MAPK14,MAPK12,CACNA1S,CAMK2A,PRKAR1A,CACNB1,CAMK2G,CACNA2D1,GRB2,MAP2K3,MAP2K6,MAPK3,PRKAR2A"]
["Leukocyte Extravasation Signaling",0.47863009232263798,0.69599999999999995,"MAPK14,VCL,MAPK12,ACTC1,MSN,ACTA2,ACTN1,RHOA,MYL6,ACTB,ITGB1,GRB2,ACTN2,ACTA1,Actn3,RAC1"]
["Huntington's Disease Signaling",0.47973344863668899,0.69199999999999995,"HSPA1A/HSPA1B,EGFR,ATP5F1,CLTC,SDHA,YKT6,SDHB,HSPA9,HSPA4,HSPA8,GRB2,ATP5A1,CLTB,CTSD,CAPNS1,TGM2,MAPK3,CAPN2"]
["Cardiac Hypertrophy Signaling",0.54200089040162402,0.68400000000000005,"MAPK14,MAPK12,CACNA1S,PRKAR1A,RHOA,MYL6,MYL1,MYLPF,GRB2,MAP2K3,MAP2K6,MAPK3,PRKAR2A"]
["Aryl Hydrocarbon Receptor Signaling",0.545757861091271,0.68799999999999994,"GSTM1,HSPB7,GSTM5,ALDH6A1,GSTM3,ALDH2,HSP90AB1,CTSD,ALDH4A1,TGM2,MAPK3"]
["Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis",0.545757861091271,0.68799999999999994,"CAMK2B,MAPK14,CAMK2G,GRB2,MAP2K3,MAP2K6,MIF,RAC1,CAMK2A,RHOA,MAPK3"]
["Gα12/13 Signaling",0.55080769640540295,0.69199999999999995,"CDH13,MYL6,MYL1,MAPK12,MYLPF,GRB2,F2,RHOA,MAPK3"]
["G Beta Gamma Signaling",0.55080769640540295,0.69199999999999995,"CAV3,EGFR,CACNB1,CACNA1S,CACNA2D1,GRB2,PRKAR1A,MAPK3,PRKAR2A"]
["Cdc42 Signaling",0.55080769640540295,0.69199999999999995,"MYL6,MAPK14,CFL1,CLIP1,MYL1,MAPK12,ITGB1,MYLPF,CFL2"]
["Tec Kinase Signaling",0.55080769640540295,0.69199999999999995,"ACTB,MAPK12,ITGB1,JAK3,ACTC1,GRB2,ACTA2,ACTA1,RHOA"]
["Fc Epsilon RI Signaling",0.55847019473683102,0.7,"MAPK14,MAPK12,GRB2,MAP2K3,MAP2K6,RAC1,MAPK3"]
["Acute Myeloid Leukemia Signaling",0.55847019473683102,0.7,"GRB2,IDH3G,MAP2K3,IDH1,MAP2K6,IDH2,MAPK3"]
["Myc Mediated Apoptosis Signaling",0.57016427228074795,0.71399999999999997,"YWHAQ,YWHAG,MAPK12,GRB2,YWHAZ"]
["Role of MAPK Signaling in the Pathogenesis of Influenza",0.57016427228074795,0.71399999999999997,"MAPK14,MAPK12,MAP2K3,MAP2K6,MAPK3"]
["Apoptosis Signaling",0.57016427228074795,0.71399999999999997,"AIFM1,CAPNS1,MAPK3,CAPN2,SPTAN1"]
["Natural Killer Cell Signaling",0.59156163417547403,0.75,"GRB2,RAC1,MAPK3"]
["MIF Regulation of Innate Immunity",0.59156163417547403,0.75,"MAPK12,MIF,MAPK3"]
["IL-22 Signaling",0.59156163417547403,0.75,"MAPK14,MAPK12,MAPK3"]
["CD27 Signaling in Lymphocytes",0.59156163417547403,0.75,"MAPK12,MAP2K3,MAP2K6"]
["IL-3 Signaling",0.59156163417547403,0.75,"GRB2,RAC1,MAPK3"]
["CD28 Signaling in T Helper Cells",0.59156163417547403,0.75,"MAPK12,GRB2,RAC1"]
["Role of JAK family kinases in IL-6-type Cytokine Signaling",0.59156163417547403,0.75,"MAPK14,MAPK12,MAPK3"]
["Tryptophan Degradation X (Mammalian, via Tryptamine)",0.59156163417547403,0.75,"ALDH2,AKR1A1,ALDH4A1"]
["Leucine Degradation I",0.59156163417547403,0.75,"MCCC2,HMGCL,IVD"]
["Methylglyoxal Degradation III",0.59156163417547403,0.75,"AKR1B1,AKR1B10,AKR1A1"]
["Oxidative Ethanol Degradation III",0.59156163417547403,0.75,"ACSL1,ALDH2,ALDH4A1"]
["Parkinson's Signaling",0.59156163417547403,0.75,"MAPK14,PARK7,MAPK12"]
["T Cell Receptor Signaling",0.59156163417547403,0.75,"GRB2,RAC1,MAPK3"]
["Cellular Effects of Sildenafil (Viagra)",0.59429215861557305,0.66700000000000004,"MYH1,MYH7,ACTC1,CACNA1S,ACTA2,MYH10,PRKAR1A,MYH3,MYL6,MYH4,MYL1,ACTB,MYLPF,MYH8,ACTA1,PRKAR2A"]
["CREB Signaling in Neurons",0.61801640013841597,0.66700000000000004,"CAMK2B,CACNB1,CAMK2G,CACNA1S,CACNA2D1,GRB2,CAMK2A,PRKAR1A,MAPK3,PRKAR2A"]
["RAR Activation",0.63095734448019303,0.66700000000000004,"MAPK14,CSNK2B,ACTB,MAPK12,PSMC5,RAC1,PRKAR1A,PRKAR2A"]
["IL-8 Signaling",0.63095734448019303,0.66700000000000004,"EGFR,MAPK12,GRB2,CSTB,LASP1,RAC1,MAPK3,RHOA"]
["Androgen Signaling",0.63095734448019303,0.66700000000000004,"CALR,HSPA4,CACNB1,CACNA2D1,CACNA1S,PRKAR1A,MAPK3,PRKAR2A"]
["IL-12 Signaling and Production in Macrophages",0.65012969034309098,0.66700000000000004,"RAB7A,MAPK14,MAPK12,GRB2,ALB,MAPK3"]
["Death Receptor Signaling",0.65012969034309098,0.66700000000000004,"HSPB7,ACTB,ACTC1,ACTA2,ACTA1,SPTAN1"]
["Role of BRCA1 in DNA Damage Response",0.66680676921362203,1,"ACTB"]
["IL-15 Production",0.66680676921362203,1,"JAK3"]
["Angiopoietin Signaling",0.66680676921362203,1,"GRB2"]
["Cardiomyocyte Differentiation via BMP Receptors",0.66680676921362203,1,"MYH7"]
["Docosahexaenoic Acid (DHA) Signaling",0.66680676921362203,1,"GRB2"]
["Human Embryonic Stem Cell Pluripotency",0.66680676921362203,1,"GRB2"]
["DNA Methylation and Transcriptional Repression Signaling",0.66680676921362203,1,"MECP2"]
["Small Cell Lung Cancer Signaling",0.66680676921362203,1,"GRB2"]
["Thyroid Cancer Signaling",0.66680676921362203,1,"MAPK3"]
["Granzyme A Signaling",0.66680676921362203,1,"NME1"]
["Tumoricidal Function of Hepatic Natural Killer Cells",0.66680676921362203,1,"AIFM1"]
["Role of IL-17F in Allergic Inflammatory Airway Diseases",0.66680676921362203,1,"MAPK3"]
["Asparagine Degradation I",0.66680676921362203,1,"ASRGL1"]
["Arginine Biosynthesis IV",0.66680676921362203,1,"OAT"]
["Diphthamide Biosynthesis",0.66680676921362203,1,"EEF2"]
["Proline Biosynthesis II (from Arginine)",0.66680676921362203,1,"OAT"]
["Trehalose Degradation II (Trehalase)",0.66680676921362203,1,"HK2"]
["Protein Citrullination",0.66680676921362203,1,"PADI2"]
["β-alanine Degradation I",0.66680676921362203,1,"ALDH6A1"]
["Ubiquinol-10 Biosynthesis (Eukaryotic)",0.66680676921362203,1,"BCKDHA"]
["Superpathway of Citrulline Metabolism",0.66680676921362203,1,"OAT"]
["Pentose Phosphate Pathway (Oxidative Branch)",0.66680676921362203,1,"PGD"]
["PRPP Biosynthesis I",0.66680676921362203,1,"PRPS1"]
["Tetrahydrofolate Salvage from 5,10-methenyltetrahydrofolate",0.66680676921362203,1,"GART"]
["Tetrapyrrole Biosynthesis II",0.66680676921362203,1,"ALAD"]
["Choline Biosynthesis III",0.66680676921362203,1,"PHKA1"]
["Spermine Biosynthesis",0.66680676921362203,1,"SMS"]
["Oleate Biosynthesis II (Animals)",0.66680676921362203,1,"ALDH6A1"]
["Arginine Degradation VI (Arginase 2 Pathway)",0.66680676921362203,1,"OAT"]
["5-aminoimidazole Ribonucleotide Biosynthesis I",0.66680676921362203,1,"GART"]
["Proline Degradation",0.66680676921362203,1,"ALDH4A1"]
["S-methyl-5-thio-α-D-ribose 1-phosphate Degradation",0.66680676921362203,1,"APIP"]
["Phenylethylamine Degradation I",0.66680676921362203,1,"ALDH2"]
["Phosphatidylcholine Biosynthesis I",0.66680676921362203,1,"PHKA1"]
["Glutamine Biosynthesis I",0.66680676921362203,1,"GLUL"]
["NAD Phosphorylation and Dephosphorylation",0.66680676921362203,1,"ACP1"]
["Citrulline Biosynthesis",0.66680676921362203,1,"OAT"]
["Superpathway of D-myo-inositol (1,4,5)-trisphosphate Metabolism",0.66680676921362203,1,"IMPA1"]
["L-cysteine Degradation III",0.66680676921362203,1,"GOT1"]
["D-glucuronate Degradation I",0.66680676921362203,1,"AKR1A1"]
["D-myo-inositol (1,4,5)-trisphosphate Degradation",0.66680676921362203,1,"IMPA1"]
["Heme Biosynthesis II",0.66680676921362203,1,"ALAD"]
["Hypusine Biosynthesis",0.66680676921362203,1,"EIF5A"]
["Myo-inositol Biosynthesis",0.66680676921362203,1,"IMPA1"]
["Thyroid Hormone Biosynthesis",0.66680676921362203,1,"CTSD"]
["Adenine and Adenosine Salvage VI",0.66680676921362203,1,"ADK"]
["NAD Biosynthesis III",0.66680676921362203,1,"NAMPT"]
["Lactose Degradation III",0.66680676921362203,1,"PSAP"]
["Phenylalanine Degradation I (Aerobic)",0.66680676921362203,1,"QDPR"]
["D-mannose Degradation",0.66680676921362203,1,"MPI"]
["Acetate Conversion to Acetyl-CoA",0.66680676921362203,1,"ACSL1"]
["Adipogenesis pathway",0.66680676921362203,1,"FABP4"]
["Glutamate Receptor Signaling",0.66680676921362203,1,"GLUL"]
["Cancer Drug Resistance By Drug Efflux",0.66680676921362203,1,"MAPK3"]
["Hepatic Cholestasis",0.680769358693741,0.66700000000000004,"MAPK12,PPARA,PRKAR1A,PRKAR2A"]
["TR/RXR Activation",0.680769358693741,0.66700000000000004,"ATP2A1,GRB2,ME1,ENO1"]
["FLT3 Signaling in Hematopoietic Progenitor Cells",0.680769358693741,0.66700000000000004,"MAPK14,MAPK12,GRB2,MAPK3"]
["Renal Cell Carcinoma Signaling",0.680769358693741,0.66700000000000004,"ELOC,GRB2,RAC1,MAPK3"]
["GDNF Family Ligand-Receptor Interactions",0.680769358693741,0.66700000000000004,"MAPK12,GRB2,RAC1,MAPK3"]
["Pyridoxal 5'-phosphate Salvage Pathway",0.680769358693741,0.66700000000000004,"PRKAA1,MAP2K3,MAP2K6,MAPK3"]
["Gαi Signaling",0.680769358693741,0.66700000000000004,"GRB2,PRKAR1A,MAPK3,PRKAR2A"]
["Gαq Signaling",0.680769358693741,0.66700000000000004,"GYS1,GRB2,MAPK3,RHOA"]
["Gαs Signaling",0.680769358693741,0.66700000000000004,"RYR1,PRKAR1A,MAPK3,PRKAR2A"]
["UVC-Induced MAPK Signaling",0.680769358693741,0.66700000000000004,"EGFR,MAPK14,MAPK12,MAPK3"]
["Cell Cycle: G2/M DNA Damage Checkpoint Regulation",0.680769358693741,0.66700000000000004,"YWHAQ,YWHAG,CUL1,YWHAZ"]
["GABA Receptor Signaling",0.680769358693741,0.66700000000000004,"CACNB1,CACNA2D1,CACNA1S,AP1B1"]
["Wnt/β-catenin Signaling",0.680769358693741,0.66700000000000004,"CSNK2B,PPP2R1A,ILK,PPP2CA"]
["NF-κB Signaling",0.680769358693741,0.66700000000000004,"EGFR,CSNK2B,GRB2,MAP2K6"]
["Erythropoietin Signaling",0.74131024130091705,0.66700000000000004,"GRB2,MAPK3"]
["Thrombopoietin Signaling",0.74131024130091705,0.66700000000000004,"GRB2,MAPK3"]
["B Cell Activating Factor Signaling",0.74131024130091705,0.66700000000000004,"MAPK14,MAPK12"]
["Factors Promoting Cardiogenesis in Vertebrates",0.74131024130091705,0.66700000000000004,"MYH7,MAPK14"]
["Maturity Onset Diabetes of Young (MODY) Signaling",0.74131024130091705,0.66700000000000004,"CACNA1S,GAPDH"]
["Growth Hormone Signaling",0.74131024130091705,0.66700000000000004,"GRB2,MAPK3"]
["Prolactin Signaling",0.74131024130091705,0.66700000000000004,"GRB2,MAPK3"]
["Primary Immunodeficiency Signaling",0.74131024130091705,0.66700000000000004,"JAK3,IGHM"]
["April Mediated Signaling",0.74131024130091705,0.66700000000000004,"MAPK14,MAPK12"]
["VEGF Family Ligand-Receptor Interactions",0.74131024130091705,0.66700000000000004,"GRB2,MAPK3"]
["ErbB4 Signaling",0.74131024130091705,0.66700000000000004,"GRB2,MAPK3"]
["Dopamine Degradation",0.74131024130091705,0.66700000000000004,"ALDH2,ALDH4A1"]
["Creatine-phosphate Biosynthesis",0.74131024130091705,0.66700000000000004,"CKMT2,CKM"]
["2-ketoglutarate Dehydrogenase Complex",0.74131024130091705,0.66700000000000004,"DLD,OGDH"]
["NAD Salvage Pathway II",0.74131024130091705,0.66700000000000004,"NT5C3A,ACP1"]
["Triacylglycerol Degradation",0.74131024130091705,0.66700000000000004,"PRDX6,CES1"]
["Thioredoxin Pathway",0.74131024130091705,0.66700000000000004,"TXN,TXNRD1"]
["Calcium Transport I",0.74131024130091705,0.66700000000000004,"ATP2A3,ATP2A1"]
["Pentose Phosphate Pathway",0.74131024130091705,0.66700000000000004,"PGD,TALDO1"]
["Histamine Degradation",0.74131024130091705,0.66700000000000004,"ALDH2,ALDH4A1"]
["Glycogen Biosynthesis II (from UDP-D-Glucose)",0.74131024130091705,0.66700000000000004,"GYS1,UGP2"]
["Putrescine Degradation III",0.74131024130091705,0.66700000000000004,"ALDH2,ALDH4A1"]
["Fatty Acid α-oxidation",0.74131024130091705,0.66700000000000004,"ALDH2,ALDH4A1"]
["Methionine Degradation I (to Homocysteine)",0.74131024130091705,0.66700000000000004,"MAT2A,AHCY"]
["Cysteine Biosynthesis III (mammalia)",0.74131024130091705,0.66700000000000004,"MAT2A,AHCY"]
["Estrogen Receptor Signaling",0.74131024130091705,0.66700000000000004,"GRB2,MAPK3"]
["Antigen Presentation Pathway",0.74131024130091705,0.66700000000000004,"CALR,CANX"]
["GPCR-Mediated Integration of Enteroendocrine Signaling Exemplified by an L Cell",0.74131024130091705,0.66700000000000004,"PRKAR1A,PRKAR2A"]