The Complement System Contributes to Functional Antibody-Mediated Responses Induced by Immunization with Plasmodium falciparum Malaria Sporozoites

Supplemental material

• Supplemental file 1 -

  Supplemental materials and methods.

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• Supplemental file 2 -

  Legends for Fig. S1 to S4.

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• Supplemental file 3 -

  Table S1. Total IgG concentrations.

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• Supplemental file 4 -

  Table S2. CSP depletion efficacy.

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• Supplemental file 5 -

  Fig. S1. Induction of IgG and IgM sporozoite-specific antibodies in control versus CPS-immunized volunteers.

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• Supplemental file 6 -

  Fig. S2. Antibody specificity of CPS-induced sporozoite-specific IgG and IgM antibodies.

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• Supplemental file 7 -

  Fig. S3. Importance of antibody-independent pathways for complement activation and sporozoite lysis.

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• Supplemental file 8 -

  Fig. S4. Correlation analysis of invasion inhibition and cumulative parasitemia or prepatent period.

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