Supplementary table S5.3,,,,,,,,,,,,,,,,,,,, Gene Name,Breast Cancer Driver,Effect,Severity,Genomic Location,Ref,Alt,Amino Acid,cDNA Location,Alt Tumour,VAF Tumour,Tumour Depth,Alt Normal,VAF Normal,Normal Depth,Functional Class,All Mutation Changes,dbSNP,COSMIC,COSMIC IDs,CGC ARHGEF19,,NON_SYNONYMOUS_CODING,MODERATE,1:16532775,C,T,p.Gly400Ser,c.1198C>T,31,0.242,128,0,0,122,MISSENSE,p.Gly400Ser/c.1198C>T:p.Gly83Ser/c.247C>T:p.Gly88Ser/c.262C>T,.,NA,NA,NA ARMC6,,NON_SYNONYMOUS_CODING,MODERATE,19:19166113,G,A,p.Ala18Thr,c.52G>A,10,0.031,327,0,0,117,MISSENSE,p.Ala18Thr/c.52G>A:p.Ala262Thr/c.784G>A:p.Ala330Thr/c.988G>A:p.Ala355Thr/c.1063G>A:p.Ala44Thr/c.130G>A,.,x2 ids,3403977:3403978,NA ARRDC5,,NON_SYNONYMOUS_CODING,MODERATE,19:4891323,G,A,p.Ala255Val,c.764G>A,45,0.188,239,0,0,160,MISSENSE,p.Ala255Val/c.764G>A,.,NA,NA,NA ASXL2,,NON_SYNONYMOUS_CODING,MODERATE,2:25978935,C,T,p.Glu302Lys,c.904C>T,42,0.433,97,0,0,117,MISSENSE,p.Glu302Lys/c.904C>T:p.Glu330Lys/c.988C>T:p.Glu70Lys/c.208C>T,.,x2 ids,418770:418771,NA C2orf54,,NON_SYNONYMOUS_CODING,MODERATE,2:241829552,G,T,p.Thr106Lys,c.317G>T,22,0.214,103,0,0,73,MISSENSE,p.Thr106Lys/c.317G>T:p.Thr255Lys/c.764G>T:p.Thr87Lys/c.260G>T,rs370614463,NA,NA,NA DNAH9,,SYNONYMOUS_CODING,LOW,17:11711079,G,A,p.Pro2817Pro,c.8451G>A,13,0.213,61,0,0,88,SILENT,p.Pro2817Pro/c.8451G>A,rs142271550,NA,NA,NA KRT33B,,SYNONYMOUS_CODING,LOW,17:39521225,T,C,p.Thr301Thr,c.903T>C,12,0.13,92,1,0.02,51,SILENT,p.Thr301Thr/c.903T>C,.,NA,NA,NA PC,,NON_SYNONYMOUS_CODING,MODERATE,11:66620277,G,A,p.Pro515Leu,c.1544G>A,22,0.156,141,0,0,91,MISSENSE,p.Pro515Leu/c.1544G>A,.,NA,NA,NA SLFNL1,,NON_SYNONYMOUS_CODING,MODERATE,1:41486311,C,A,p.Val8Leu,c.22C>A,18,0.281,64,0,0,67,MISSENSE,p.Val8Leu/c.22C>A,.,NA,NA,NA VWA7,,STOP_GAINED,HIGH,6:31734429,G,A,p.Arg659*,c.1975G>A,37,0.245,151,0,0,104,NONSENSE,p.Arg659*/c.1975G>A,.,NA,NA,NA SETDB1,,FRAME_SHIFT,HIGH,1:150933397,AC,A,p.X954X,c.2860*>-C,58,0.187,310,0,0,280,FRAME_SHIFT,p.X954X/c.2860*>-C,.,NA,NA,NA