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{"sheet":"NC-2-VS-SI-TUG1.GeneDiffExpFilt","index":0,"n_rows":646,"n_cols":14,"rows_kept":646,"cut":false,"hidden":false,"merged":[]}
["Table S2"]
["GeneID","Length","NC-Expression","Linc00473-Expression","log2FoldChange(Linc00473/NC)","FDR","Up/Down-Regulation(Linc00473/NC)","Pvalue","Symbol","Cellular Component","Molecular Function","Biological Process","Kegg Orthology","Nr Description"]
[4322,2735,0.01,2.04,7.6724253419715,1.26039217057057e-12,"Up",7.77818e-14,"MMP13","GO:0031012//extracellular matrix","GO:0004175//endopeptidase activity;GO:0046914//transition metal ion binding","GO:0032963//collagen metabolic process;GO:0019538//protein metabolic process","K07994//matrix metalloproteinase-13 (collagenase 3) [EC:3.4.24.-]","gi|4505209|ref|NP_002418.1|//collagenase 3 preproprotein [Homo sapiens]"]
[8710,2244,0.01,2,7.64385618977472,1.6984831899631e-9,"Up",1.421698e-10,"SERPINB7","GO:0044424//intracellular part","GO:0004866//endopeptidase inhibitor activity","GO:0010466//negative regulation of peptidase activity;GO:0006508//proteolysis","K13964//serpin B7","gi|694971647|ref|XP_009432383.1|//PREDICTED: serpin B7 isoform X1 [Pan troglodytes];gi|387912532|ref|NP_001248760.1|//serpin B7 isoform 2 [Homo sapiens] "]
[3885,1713,0.01,1.92,7.58496250072116,1.92527589031897e-7,"Up",2.12532e-8,"KRT34","GO:0043234//protein complex","GO:0005488//binding","GO:0009888//tissue development","K07604//type I keratin, acidic","gi|14917119|ref|NP_066293.2|//keratin, type I cuticular Ha4 [Homo sapiens];gi|767994730|ref|XP_011523095.1|//PREDICTED: keratin, type I cuticular Ha4 isoform X1 [Homo sapiens]"]
[4207,1978,0.01,1.87,7.54689445988764,3.98435731530424e-8,"Up",4.00454e-9,"BORCS8-MEF2B","GO:0043234//protein complex","GO:0019899//enzyme binding","GO:0010467//gene expression;GO:0048513//animal organ development;GO:0006351//transcription, DNA-templated","K09261//MADS-box transcription enhancer factor 2B","gi|795435066|ref|XP_011949923.1|//PREDICTED: myocyte-specific enhancer factor 2B isoform X1 [Cercocebus atys];gi|795268533|ref|XP_011720253.1|//PREDICTED: myocyte-specific enhancer factor 2B isoform X1 [Macaca nemestrina]"]
[107986353,3507,0.01,1.31,7.03342300153745,3.43883956225218e-10,"Up",2.67876e-11,"LOC107986353","NA","NA","NA","K14316//nuclear pore complex protein Nup121","gi|768043242|ref|XP_006726288.2|//PREDICTED: putative POM121-like protein 1-like [Homo sapiens]"]
[29970,2608,0.01,1.08,6.75488750216347,2.03609937270087e-6,"Up",2.59858e-7,"SCHIP1","GO:0044424//intracellular part","GO:0005515//protein binding","GO:0008406//gonad development;GO:0008202//steroid metabolic process;GO:0022602//ovulation cycle process;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0009887//animal organ morphogenesis;GO:0060537//muscle tissue development;GO:0001667//ameboidal-type cell migration","NA","gi|7657540|ref|NP_055390.1|//schwannomin-interacting protein 1 isoform 1 [Homo sapiens];gi|308193344|ref|NP_001184036.1|//schwannomin-interacting protein 1 isoform 2 [Homo sapiens];gi|148683562|gb|EDL15509.1|//schwannomin interacting protein 1, partial [Mus musculus];gi|308193346|ref|NP_001184037.1|//schwannomin-interacting protein 1 isoform 3 [Homo sapiens]"]
[84109,2347,0.01,1.04,6.70043971814109,2.12706838709677e-5,"Up",3.1772e-6,"QRFPR","GO:0031224//intrinsic component of membrane","GO:0008188//neuropeptide receptor activity","GO:0007166//cell surface receptor signaling pathway","K08378//G protein-coupled receptor 103","gi|157738685|ref|NP_937822.2|//pyroglutamylated RFamide peptide receptor [Homo sapiens];gi|16566347|gb|AAL26488.1|AF411117_1//G protein-coupled receptor [Homo sapiens]"]
[4312,2067,0.44,43.7,6.63398594575066,2.19483602482759e-195,"Up",3.93194e-198,"MMP1","GO:0031012//extracellular matrix","GO:0004175//endopeptidase activity;GO:0046914//transition metal ion binding","GO:0032963//collagen metabolic process;GO:0002376//immune system process;GO:0019538//protein metabolic process;GO:0051704//multi-organism process;GO:0007599//hemostasis","K01388//matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]","gi|4505215|ref|NP_002412.1|//interstitial collagenase isoform 1 preproprotein [Homo sapiens];gi|54697154|gb|AAV38949.1|//matrix metalloproteinase 1 (interstitial collagenase) [Homo sapiens] "]
[4314,1906,0.19,16.48,6.43857301373963,3.4811418972973e-66,"Up",3.18266e-68,"MMP3","GO:0031012//extracellular matrix;GO:0043231//intracellular membrane-bounded organelle;GO:0032991//macromolecular complex;GO:0043005//neuron projection","GO:0004175//endopeptidase activity;GO:0005515//protein binding;GO:0046914//transition metal ion binding","GO:0032963//collagen metabolic process;GO:0009611//response to wounding;GO:0001101//response to acid chemical;GO:0019538//protein metabolic process;GO:0034097//response to cytokine;GO:0022414//reproductive process;GO:0002237//response to molecule of bacterial origin;GO:0043627//response to estrogen;GO:0031668//cellular response to extracellular stimulus","K01394//matrix metalloproteinase-3 (stromelysin 1, progelatinase) [EC:3.4.24.17]","gi|4505217|ref|NP_002413.1|//stromelysin-1 preproprotein [Homo sapiens]"]
[1565,1767,0.01,0.8,6.32192809488736,0.0009874296852071,"Up",0.000206172,"CYP2D6","GO:0043231//intracellular membrane-bounded organelle;GO:0031090//organelle membrane","GO:0005506//iron ion binding;GO:0016712//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen","GO:0006721//terpenoid metabolic process;GO:0044092//negative regulation of molecular function;GO:0009698//phenylpropanoid metabolic process;GO:0009820//alkaloid metabolic process;GO:0017144//drug metabolic process;GO:0055114//oxidation-reduction process;GO:0090346//cellular organofluorine metabolic process","K17712//cytochrome P450 family 2 subfamily D polypeptide 6 [EC:1.14.14.1]","gi|768023770|ref|XP_011528268.1|//PREDICTED: cytochrome P450 2D6 isoform X1 [Homo sapiens];gi|768023783|ref|XP_011528272.1|//PREDICTED: cytochrome P450 2D6 isoform X4 [Homo sapiens];gi|392513723|ref|NP_001020332.2|//cytochrome P450 2D6 isoform 2 [Homo sapiens];gi|768023775|ref|XP_011528270.1|//PREDICTED: cytochrome P450 2D6 isoform X2 [Homo sapiens];gi|62088564|dbj|BAD92729.1|//debrisoquine 4-hydroxylase mutant allele variant [Homo sapiens]"]
[26579,2151,0.01,0.8,6.32192809488736,0.000215139239958946,"Up",3.88468e-5,"MYEOV","NA","NA","NA","NA","gi|42794612|ref|NP_620123.2|//myeloma-overexpressed gene protein isoform 1 [Homo sapiens]"]
[9976,2052,0.01,0.76,6.24792751344359,0.000987137632653061,"Up",0.000206172,"CLEC2B","GO:0016021//integral component of membrane","GO:0030246//carbohydrate binding","NA","K10071//C-type lectin domain family 2 member B","gi|426371600|ref|XP_004052731.1|//PREDICTED: C-type lectin domain family 2 member B [Gorilla gorilla gorilla]"]
[90865,2340,0.01,0.69,6.10852445677817,0.000215212867351129,"Up",3.88468e-5,"IL33","GO:0044421//extracellular region part","GO:0005102//receptor binding","GO:0002696//positive regulation of leukocyte activation;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0031349//positive regulation of defense response;GO:0032722//positive regulation of chemokine production","K12967//interleukin 33","gi|314122337|ref|NP_001186570.1|//interleukin-33 isoform c [Homo sapiens] ;gi|930588931|ref|NP_001300975.1|//interleukin-33 isoform d [Homo sapiens];gi|313851030|ref|NP_001186569.1|//interleukin-33 isoform b [Homo sapiens] ;gi|15559209|ref|NP_254274.1|//interleukin-33 isoform a precursor [Homo sapiens];gi|930588933|ref|NP_001300977.1|//interleukin-33 isoform e [Homo sapiens]"]
[445815,7495,0.01,0.68,6.08746284125034,3.15536380782918e-11,"Up",2.1909e-12,"PALM2-AKAP2","NA","GO:0005515//protein binding","NA","K16519//A-kinase anchor protein 2","gi|6005709|ref|NP_009134.1|//PALM2-AKAP2 protein isoform 1 [Homo sapiens];gi|119579458|gb|EAW59054.1|//hCG28765, isoform CRA_d [Homo sapiens]"]
[127294,5800,0.01,0.3,4.90689059560852,0.00046035030085796,"Up",8.94936e-5,"MYOM3","NA","NA","NA","K12567//titin [EC:2.7.11.1]","gi|155969693|ref|NP_689585.3|//myomesin-3 [Homo sapiens]"]
[150094,4706,0.14,3.88,4.79255792012952,1.0125290475e-34,"Up",2.00154e-36,"SIK1","GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part","GO:0046872//metal ion binding;GO:0032559//adenyl ribonucleotide binding;GO:0004672//protein kinase activity","GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0000278//mitotic cell cycle;GO:0006464//cellular protein modification process;GO:0032501//multicellular organismal process;GO:0050793//regulation of developmental process;GO:0035556//intracellular signal transduction;GO:0006915//apoptotic process","K19008//serine/threonine-protein kinase SIK1 [EC:2.7.11.1]","gi|116256471|ref|NP_775490.2|//serine/threonine-protein kinase SIK1 [Homo sapiens];gi|768020313|ref|XP_011527776.1|//PREDICTED: serine/threonine-protein kinase SIK1 isoform X1 [Homo sapiens]"]
[11009,1845,0.99,20.82,4.39439773321981,1.4447972115e-62,"Up",1.428018e-64,"IL24","GO:0044421//extracellular region part","GO:0005102//receptor binding","GO:0012501//programmed cell death","K05444//interleukin 19/20/24","gi|297632406|ref|NP_001172087.1|//interleukin-24 isoform 5 [Homo sapiens];gi|5803086|ref|NP_006841.1|//interleukin-24 isoform 1 precursor [Homo sapiens];gi|297632401|ref|NP_001172085.1|//interleukin-24 isoform 3 precursor [Homo sapiens];gi|297632404|ref|NP_001172086.1|//interleukin-24 isoform 4 precursor [Homo sapiens]"]
[2150,2767,0.03,0.61,4.34577483684173,0.000460496629624921,"Up",8.94936e-5,"F2RL1","GO:0043231//intracellular membrane-bounded organelle;GO:0016021//integral component of membrane","GO:0008528//G-protein coupled peptide receptor activity;GO:0005515//protein binding","GO:0007596//blood coagulation;GO:0050921//positive regulation of chemotaxis;GO:0007166//cell surface receptor signaling pathway;GO:0002687//positive regulation of leukocyte migration;GO:0051480//regulation of cytosolic calcium ion concentration","K04234//coagulation factor II (thrombin) receptor-like 1","gi|1208540|gb|AAA90957.1|//protease-activated receptor 2, partial [Homo sapiens];gi|34577052|ref|NP_005233.3|//proteinase-activated receptor 2 precursor [Homo sapiens]"]
[5743,4507,0.05,0.89,4.15380533607904,3.90031088162828e-7,"Up",4.49832e-8,"PTGS2","GO:0032991//macromolecular complex;GO:0042995//cell projection;GO:0044459//plasma membrane part;GO:0044432//endoplasmic reticulum part;GO:0031090//organelle membrane","GO:0016209//antioxidant activity;GO:0016705//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0005515//protein binding;GO:0016701//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;GO:0005506//iron ion binding","GO:0003006//developmental process involved in reproduction;GO:0019229//regulation of vasoconstriction;GO:0009746//response to hexose;GO:0043271//negative regulation of ion transport;GO:0043627//response to estrogen;GO:0002237//response to molecule of bacterial origin;GO:0001819//positive regulation of cytokine production;GO:0001503//ossification;GO:0007292//female gamete generation;GO:0002042//cell migration involved in sprouting angiogenesis;GO:0022405//hair cycle process;GO:0031347//regulation of defense response;GO:0010038//response to metal ion;GO:0001516//prostaglandin biosynthetic process;GO:0007611//learning or memory;GO:0050806//positive regulation of synaptic transmission;GO:0045600//positive regulation of fat cell differentiation;GO:0006939//smooth muscle contraction;GO:0001660//fever generation;GO:0006915//apoptotic process;GO:0031960//response to corticosteroid;GO:0031328//positive regulation of cellular biosynthetic process;GO:0001963//synaptic transmission, dopaminergic;GO:0033273//response to vitamin;GO:0007049//cell cycle;GO:0048167//regulation of synaptic plasticity;GO:0008284//positive regulation of cell proliferation","K11987//prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]","gi|4506265|ref|NP_000954.1|//prostaglandin G/H synthase 2 precursor [Homo sapiens]"]
[3598,1376,0.09,1.6,4.15200309344505,0.000366109199609248,"Up",6.9454e-5,"IL13RA2","GO:0031224//intrinsic component of membrane;GO:0044421//extracellular region part","GO:0004888//transmembrane signaling receptor activity","GO:0007166//cell surface receptor signaling pathway","K05077//interleukin 13 receptor alpha-2","gi|10834992|ref|NP_000631.1|//interleukin-13 receptor subunit alpha-2 precursor [Homo sapiens]"]
[5055,1922,0.25,4.39,4.13422093976063,4.93893487684729e-15,"Up",2.4774e-16,"SERPINB2","GO:0016020//membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0044421//extracellular region part","GO:0004866//endopeptidase inhibitor activity","GO:0010466//negative regulation of peptidase activity;GO:0030195//negative regulation of blood coagulation;GO:0006508//proteolysis;GO:0043066//negative regulation of apoptotic process","K19821//plasminogen activator inhibitor 2","gi|4505595|ref|NP_002566.1|//plasminogen activator inhibitor 2 [Homo sapiens]"]
[114960,2058,0.08,1.03,3.68650052718322,0.000739655430063772,"Up",0.0001504624,"TSGA13","NA","NA","NA","K12581//CCR4-NOT transcription complex subunit 7/8;K17267//coatomer subunit gamma;K04613//vomeronasal 2 receptor;K12025//tripartite motif-containing protein 52","gi|16418411|ref|NP_443165.1|//testis-specific gene 13 protein [Homo sapiens]"]
[83851,6557,0.02,0.24,3.58496250072116,0.000827550770708283,"Up",0.000170336,"SYT16","NA","GO:0008289//lipid binding;GO:0042802//identical protein binding;GO:0046983//protein dimerization activity","NA","K19328//synaptotagmin-14/16","gi|123173752|ref|NP_114120.2|//synaptotagmin-16 [Homo sapiens];gi|767981661|ref|XP_011535523.1|//PREDICTED: synaptotagmin-16 isoform X3 [Homo sapiens];gi|767981674|ref|XP_011535529.1|//PREDICTED: synaptotagmin-16 isoform X7 [Homo sapiens];gi|767981665|ref|XP_011535524.1|//PREDICTED: synaptotagmin-16 isoform X4 [Homo sapiens];gi|767981668|ref|XP_011535525.1|//PREDICTED: synaptotagmin-16 isoform X5 [Homo sapiens];gi|767981670|ref|XP_011535526.1|//PREDICTED: synaptotagmin-16 isoform X6 [Homo sapiens];gi|767981678|ref|XP_011535531.1|//PREDICTED: synaptotagmin-16 isoform X9 [Homo sapiens];gi|767981676|ref|XP_011535530.1|//PREDICTED: synaptotagmin-16 isoform X8 [Homo sapiens];gi|767981659|ref|XP_011535522.1|//PREDICTED: synaptotagmin-16 isoform X2 [Homo sapiens]"]
[55567,6580,0.04,0.48,3.58496250072116,2.7852527961165e-5,"Up",4.25324e-6,"DNAH3","GO:0030286//dynein complex;GO:0005930//axoneme","GO:0032559//adenyl ribonucleotide binding;GO:0003774//motor activity","GO:0048870//cell motility;GO:0007017//microtubule-based process","K10408//dynein heavy chain, axonemal","gi|767988650|ref|XP_011544190.1|//PREDICTED: dynein heavy chain 3, axonemal isoform X7 [Homo sapiens];gi|578828592|ref|XP_006721125.1|//PREDICTED: dynein heavy chain 3, axonemal isoform X2 [Homo sapiens];gi|767988654|ref|XP_011544192.1|//PREDICTED: dynein heavy chain 3, axonemal isoform X8 [Homo sapiens];gi|767988642|ref|XP_011544186.1|//PREDICTED: dynein heavy chain 3, axonemal isoform X3 [Homo sapiens];gi|767988646|ref|XP_011544188.1|//PREDICTED: dynein heavy chain 3, axonemal isoform X5 [Homo sapiens];gi|767988644|ref|XP_011544187.1|//PREDICTED: dynein heavy chain 3, axonemal isoform X4 [Homo sapiens];gi|24308169|ref|NP_060009.1|//dynein heavy chain 3, axonemal [Homo sapiens];gi|568894746|ref|XP_006544358.1|//PREDICTED: LOW QUALITY PROTEIN: dynein heavy chain 3, axonemal isoform X1 [Mus musculus];gi|767988648|ref|XP_011544189.1|//PREDICTED: dynein heavy chain 3, axonemal isoform X6 [Homo sapiens];gi|767988638|ref|XP_011544184.1|//PREDICTED: dynein heavy chain 3, axonemal isoform X1 [Homo sapiens]"]
[50486,978,4.49,52.89,3.55820762530019,1.5103839307563e-75,"Up",1.110302e-77,"G0S2","NA","NA","NA","NA","gi|7657104|ref|NP_056529.1|//G0/G1 switch protein 2 [Homo sapiens]"]
[51129,1883,1.34,15.71,3.55137827483642,5.29105142959641e-45,"Up",7.28876e-47,"ANGPTL4","GO:0031012//extracellular matrix","GO:0005515//protein binding;GO:0030234//enzyme regulator activity","GO:0006950//response to stress;GO:0051004//regulation of lipoprotein lipase activity;GO:0006915//apoptotic process;GO:0048869//cellular developmental process;GO:0045765//regulation of angiogenesis;GO:0023052//signaling;GO:0055088//lipid homeostasis;GO:0006629//lipid metabolic process;GO:0051259//protein oligomerization","K08767//angiopoietin-like 4","gi|37181670|gb|AAQ88642.1|//NL2 [Homo sapiens]"]
[25907,1876,1.28,14.57,3.50878516206451,5.4326928e-40,"Up",8.82628e-42,"TMEM158","GO:0016020//membrane","GO:0005488//binding","NA","K06732//CUB domain-containing protein 1","gi|16904374|gb|AAL30845.1|AF438313_1//Ras-induced senescence 1 [Homo sapiens]"]
[116211,1071,1.66,18.19,3.45389039630456,3.10972225990783e-27,"Up",8.33716e-29,"TM4SF19","NA","NA","NA","NA","gi|325974477|ref|NP_001191827.1|//transmembrane 4 L6 family member 19 isoform 3 [Homo sapiens];gi|325974475|ref|NP_001191826.1|//transmembrane 4 L6 family member 19 isoform 2 [Homo sapiens]"]
[3576,1718,6.29,52.13,3.05098193771672,6.60113311764706e-115,"Up",2.7729e-117,"CXCL8","GO:0044421//extracellular region part","GO:0005125//cytokine activity;GO:0045236//CXCR chemokine receptor binding","GO:0002690//positive regulation of leukocyte chemotaxis;GO:0007166//cell surface receptor signaling pathway;GO:0032496//response to lipopolysaccharide;GO:0048565//digestive tract development;GO:0050927//positive regulation of positive chemotaxis;GO:0007155//cell adhesion;GO:0008283//cell proliferation;GO:0019932//second-messenger-mediated signaling;GO:0045069//regulation of viral genome replication;GO:0006952//defense response;GO:0022402//cell cycle process;GO:0048646//anatomical structure formation involved in morphogenesis;GO:0002274//myeloid leukocyte activation","K10030//interleukin 8","gi|10834978|ref|NP_000575.1|//interleukin-8 precursor [Homo sapiens]"]
[414899,862,0.43,3.53,3.03725961856908,0.000223388878854025,"Up",4.04606e-5,"BLID","GO:0043231//intracellular membrane-bounded organelle","NA","GO:0012501//programmed cell death","NA","gi|221316605|ref|NP_001001786.2|//BH3-like motif-containing cell death inducer [Homo sapiens]"]
[9076,3452,0.34,2.56,2.91253715874966,3.08636772192513e-11,"Up",2.13918e-12,"CLDN1","GO:0016021//integral component of membrane;GO:0043296//apical junction complex","GO:0005515//protein binding","GO:0016337//single organismal cell-cell adhesion;GO:0051704//multi-organism process","K06087//claudin","gi|10863887|ref|NP_066924.1|//claudin-1 [Homo sapiens]"]
[134285,1263,0.31,2.27,2.87235217690404,0.000795406470822042,"Up",0.0001631792,"TMEM171","GO:0031224//intrinsic component of membrane","NA","NA","NA","gi|239735596|ref|NP_775761.4|//transmembrane protein 171 isoform 1 [Homo sapiens];gi|239735594|ref|NP_001154814.1|//transmembrane protein 171 isoform 2 [Homo sapiens];gi|767935320|ref|XP_011541458.1|//PREDICTED: transmembrane protein 171 isoform X1 [Homo sapiens]"]
[7980,2441,21.82,156.87,2.84584646924439,0,"Up",0,"TFPI2","GO:0031012//extracellular matrix","GO:0004866//endopeptidase inhibitor activity;GO:0005198//structural molecule activity","GO:0007599//hemostasis","K02599//Notch 1;K03909//tissue factor pathway inhibitor","gi|795252577|ref|XP_011810462.1|//PREDICTED: tissue factor pathway inhibitor 2 isoform X2 [Colobus angolensis palliatus];gi|795252571|ref|XP_011810461.1|//PREDICTED: tissue factor pathway inhibitor 2 isoform X1 [Colobus angolensis palliatus]"]
[768,1561,1,7.14,2.83592407425437,1.47639144836601e-13,"Up",8.37242e-15,"CA9","GO:0031981//nuclear lumen;GO:0031224//intrinsic component of membrane;GO:0044459//plasma membrane part;GO:0005902//microvillus","GO:0016836//hydro-lyase activity;GO:0046914//transition metal ion binding","GO:0048545//response to steroid hormone;GO:0006810//transport;GO:0048729//tissue morphogenesis;GO:0006950//response to stress;GO:0044237//cellular metabolic process","K01672//carbonic anhydrase [EC:4.2.1.1]","gi|694929883|ref|XP_528593.3|//PREDICTED: carbonic anhydrase 9 isoform X4 [Pan troglodytes]"]
[57214,7128,1.08,7.52,2.79970134951417,2.66748614901961e-64,"Up",2.52116e-66,"CEMIP","GO:0044424//intracellular part","NA","NA","K19031//cell migration-inducing and hyaluronan-binding protein [EC:3.2.1.35]","gi|426380059|ref|XP_004056701.1|//PREDICTED: protein KIAA1199 homolog isoform 1 [Gorilla gorilla gorilla];gi|426380061|ref|XP_004056702.1|//PREDICTED: protein KIAA1199 homolog isoform 2 [Gorilla gorilla gorilla]"]
[1846,5665,0.67,4.61,2.78253374997157,1.00305283068493e-30,"Up",2.26164e-32,"DUSP4","GO:0031981//nuclear lumen","GO:0008138//protein tyrosine/serine/threonine phosphatase activity","GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0000165//MAPK cascade;GO:0006464//cellular protein modification process;GO:0001704//formation of primary germ layer;GO:0002224//toll-like receptor signaling pathway","K04459//dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]","gi|16950652|ref|NP_476499.1|//dual specificity protein phosphatase 4 isoform 2 [Homo sapiens];gi|1246072|gb|AAB35870.1|//threonine, tyrosine phosphatase, partial [Homo sapiens]"]
[316,4881,0.87,5.54,2.67079867020046,1.15735340895522e-28,"Up",2.87408e-30,"AOX1","GO:0044424//intracellular part","GO:0016623//oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor;GO:0000166//nucleotide binding;GO:0046914//transition metal ion binding;GO:0016726//oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor;GO:0051536//iron-sulfur cluster binding;GO:0050662//coenzyme binding","GO:0008152//metabolic process;GO:0006952//defense response","K00157//aldehyde oxidase [EC:1.2.3.1]","gi|71773480|ref|NP_001150.3|//aldehyde oxidase [Homo sapiens];gi|767917828|ref|XP_011509364.1|//PREDICTED: aldehyde oxidase isoform X1 [Homo sapiens]"]
[390,2738,38.53,239.47,2.63579084016595,0,"Up",0,"RND3","GO:0016020//membrane;GO:0012505//endomembrane system;GO:0043231//intracellular membrane-bounded organelle","GO:0032561//guanyl ribonucleotide binding;GO:0017111//nucleoside-triphosphatase activity","GO:0007010//cytoskeleton organization;GO:0035556//intracellular signal transduction;GO:0009207//purine ribonucleoside triphosphate catabolic process","K07859//Rho family GTPase 3","gi|724851156|ref|XP_010366888.1|//PREDICTED: rho-related GTP-binding protein RhoE [Rhinopithecus roxellana]"]
[3745,11856,0.07,0.43,2.61890983264449,3.5304803697479e-6,"Up",4.67154e-7,"KCNB1","GO:0005887//integral component of plasma membrane","GO:0005267//potassium channel activity;GO:0005488//binding","GO:0034220//ion transmembrane transport;GO:0030001//metal ion transport;GO:0030073//insulin secretion;GO:0015980//energy derivation by oxidation of organic compounds","K04885//potassium voltage-gated channel Shab-related subfamily B member 1","gi|186798|gb|AAA36156.1|//voltage-gated potassium channel [Homo sapiens]"]
[54206,3252,8.68,51.46,2.56768450928932,2.1121932e-171,"Up",4.9582e-174,"ERRFI1","GO:0043231//intracellular membrane-bounded organelle;GO:0009898//cytoplasmic side of plasma membrane","GO:0019900//kinase binding","GO:0007176//regulation of epidermal growth factor-activated receptor activity;GO:0048730//epidermis morphogenesis;GO:0001944//vasculature development;GO:0030856//regulation of epithelial cell differentiation;GO:0001933//negative regulation of protein phosphorylation","K08886//activated CDC42 kinase 1 [EC:2.7.10.2 2.7.11.1]","gi|10047086|ref|NP_061821.1|//ERBB receptor feedback inhibitor 1 [Homo sapiens]"]
[8639,3708,0.25,1.48,2.56559717585423,4.64792311764706e-5,"Up",7.41922e-6,"AOC3","GO:0031224//intrinsic component of membrane","GO:0016641//oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor;GO:0042802//identical protein binding;GO:0046914//transition metal ion binding;GO:0048037//cofactor binding","GO:0006807//nitrogen compound metabolic process;GO:0006952//defense response;GO:0009987//cellular process","K00276//primary-amine oxidase [EC:1.4.3.21]","gi|767996324|ref|XP_011523721.1|//PREDICTED: membrane primary amine oxidase isoform X1 [Homo sapiens];gi|4502119|ref|NP_003725.1|//membrane primary amine oxidase isoform 1 [Homo sapiens];gi|480306390|ref|NP_001264660.1|//membrane primary amine oxidase isoform 2 [Homo sapiens];gi|767996326|ref|XP_011523722.1|//PREDICTED: membrane primary amine oxidase isoform X2 [Homo sapiens]"]
[11082,2089,0.8,4.55,2.5077946401987,2.52465011932094e-10,"Up",1.929202e-11,"ESM1","NA","GO:0005102//receptor binding;GO:0019838//growth factor binding","GO:0016049//cell growth","NA","gi|426384685|ref|XP_004058887.1|//PREDICTED: endothelial cell-specific molecule 1 isoform 1 [Gorilla gorilla gorilla];gi|426384687|ref|XP_004058888.1|//PREDICTED: endothelial cell-specific molecule 1 isoform 2 [Gorilla gorilla gorilla]"]
[8325,3186,1.46,8.18,2.48613247406173,3.17936775412844e-27,"Up",8.56316e-29,"FZD8","GO:0031224//intrinsic component of membrane;GO:0043231//intracellular membrane-bounded organelle","GO:0019904//protein domain specific binding;GO:0004888//transmembrane signaling receptor activity","GO:0001932//regulation of protein phosphorylation;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0016055//Wnt signaling pathway;GO:0048667//cell morphogenesis involved in neuron differentiation;GO:0030217//T cell differentiation;GO:0045137//development of primary sexual characteristics;GO:0007417//central nervous system development","K02375//frizzled 5/8","gi|13994190|ref|NP_114072.1|//frizzled-8 precursor [Homo sapiens]"]
[9510,4670,1.65,9.13,2.46814883573841,5.5273642e-44,"Up",7.78502e-46,"ADAMTS1","GO:0031982//vesicle;GO:0005578//proteinaceous extracellular matrix","GO:0004175//endopeptidase activity;GO:0005539//glycosaminoglycan binding;GO:0046914//transition metal ion binding","GO:0022602//ovulation cycle process;GO:0008283//cell proliferation;GO:0019538//protein metabolic process;GO:0007166//cell surface receptor signaling pathway;GO:0060343//trabecula formation","K08617//a disintegrin and metalloproteinase with thrombospondin motifs 1 [EC:3.4.24.-]","gi|50845384|ref|NP_008919.3|//A disintegrin and metalloproteinase with thrombospondin motifs 1 preproprotein [Homo sapiens]"]
[8942,2037,3.28,18.04,2.4594316186373,7.46166027019867e-36,"Up",1.392032e-37,"KYNU","GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part","GO:0016823//hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances;GO:0042802//identical protein binding;GO:0048037//cofactor binding","GO:0043650//dicarboxylic acid biosynthetic process;GO:0019359//nicotinamide nucleotide biosynthetic process;GO:0006568//tryptophan metabolic process;GO:0034097//response to cytokine;GO:0033273//response to vitamin","K01556//kynureninase [EC:3.7.1.3]","gi|795415736|ref|XP_011758126.1|//PREDICTED: kynureninase isoform X1 [Macaca nemestrina];gi|74101437|ref|NP_001028170.1|//kynureninase isoform b [Homo sapiens];gi|4504937|ref|NP_003928.1|//kynureninase isoform a [Homo sapiens]"]
[100134938,1360,0.7,3.8,2.44057259138598,6.55500720541761e-6,"Up",8.9692e-7,"UPK3BL1","GO:0031224//intrinsic component of membrane","NA","NA","K06245//laminin, beta 4;K17630//Ras GTPase-activating protein 4;K17985//activating molecule in BECN1-regulated autophagy protein 1;K12025//tripartite motif-containing protein 52","gi|767948137|ref|XP_011514650.1|//PREDICTED: DNA-directed RNA polymerase II subunit RPB11-b2 isoform X8 [Homo sapiens]"]
[2012,2804,16.3,81.57,2.32316668762748,3.56760587e-217,"Up",5.28926e-220,"EMP1","GO:0031224//intrinsic component of membrane","NA","GO:0009888//tissue development;GO:0040007//growth;GO:0032501//multicellular organismal process","K19289//peripheral myelin protein 22","gi|431908359|gb|ELK11956.1|//hypothetical protein PAL_GLEAN10015630 [Pteropus alecto]"]
[10326,2226,1.16,5.68,2.29176612437711,1.60300596038835e-8,"Up",1.529926e-9,"SIRPB1","GO:0016021//integral component of membrane","GO:0019904//protein domain specific binding;GO:0005488//binding","GO:0002376//immune system process;GO:0007165//signal transduction;GO:0034330//cell junction organization;GO:0007599//hemostasis","K06551//signal-regulatory protein alpha/beta1/gamma","gi|530425576|ref|XP_005260701.1|//PREDICTED: signal-regulatory protein beta-1 isoform X7 [Homo sapiens];gi|768013236|ref|XP_011527438.1|//PREDICTED: signal-regulatory protein beta-1 isoform X5 [Homo sapiens];gi|530425574|ref|XP_005260700.1|//PREDICTED: signal-regulatory protein beta-1 isoform X6 [Homo sapiens];gi|768013228|ref|XP_011527437.1|//PREDICTED: signal-regulatory protein beta-1 isoform X3 [Homo sapiens];gi|768013224|ref|XP_011527436.1|//PREDICTED: signal-regulatory protein beta-1 isoform X2 [Homo sapiens];gi|209529703|ref|NP_001129316.1|//signal-regulatory protein beta-1 isoform 3 precursor [Homo sapiens];gi|144953876|ref|NP_006056.2|//signal-regulatory protein beta-1 isoform 1 precursor [Homo sapiens];gi|19263929|gb|AAH25286.1|//SIRPB1 protein [Homo sapiens];gi|530425570|ref|XP_005260698.1|//PREDICTED: signal-regulatory protein beta-1 isoform X4 [Homo sapiens]"]
[1848,3395,4.65,22.54,2.27718489417683,4.02036891428571e-71,"Up",3.30312e-73,"DUSP6","GO:0031981//nuclear lumen;GO:0044444//cytoplasmic part","GO:0008138//protein tyrosine/serine/threonine phosphatase activity","GO:0046620//regulation of organ growth;GO:0001714//endodermal cell fate specification;GO:0003002//regionalization;GO:0002224//toll-like receptor signaling pathway;GO:0006915//apoptotic process;GO:0043409//negative regulation of MAPK cascade;GO:0001932//regulation of protein phosphorylation;GO:0010033//response to organic substance;GO:0006470//protein dephosphorylation;GO:0008543//fibroblast growth factor receptor signaling pathway","K04459//dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]","gi|42764687|ref|NP_073143.2|//dual specificity protein phosphatase 6 isoform b [Homo sapiens];gi|42764683|ref|NP_001937.2|//dual specificity protein phosphatase 6 isoform a [Homo sapiens]"]
[10397,3156,18.76,90.64,2.27248803330514,9.737264115e-266,"Up",9.62417999999999e-269,"NDRG1","GO:0043231//intracellular membrane-bounded organelle;GO:0016020//membrane;GO:0005856//cytoskeleton","GO:0005488//binding","GO:0010035//response to inorganic substance;GO:0002274//myeloid leukocyte activation","K18266//protein NDRG1","gi|635050263|ref|XP_007999782.1|//PREDICTED: protein NDRG1 isoform X2 [Chlorocebus sabaeus];gi|767952381|ref|XP_011515093.1|//PREDICTED: protein NDRG1 isoform X1 [Homo sapiens];gi|37655183|ref|NP_006087.2|//protein NDRG1 isoform 1 [Homo sapiens]"]
[27063,1994,1.14,5.48,2.26514206879579,1.77750651089109e-10,"Up",1.330824e-11,"ANKRD1","GO:0043231//intracellular membrane-bounded organelle;GO:0043234//protein complex;GO:0030017//sarcomere","GO:0003712//transcription cofactor activity;GO:0003676//nucleic acid binding","GO:0006355//regulation of transcription, DNA-templated;GO:0006950//response to stress;GO:0023052//signaling;GO:0006629//lipid metabolic process","K15504//serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C;K11810//MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 12","gi|585640353|ref|XP_006880391.1|//PREDICTED: ankyrin repeat domain-containing protein 1 [Elephantulus edwardii]"]
[114801,3103,0.64,3.07,2.26209484537018,3.31640880672269e-9,"Up",2.92552e-10,"TMEM200A","GO:0031224//intrinsic component of membrane","NA","NA","NA","gi|29789291|ref|NP_443145.1|//transmembrane protein 200A [Homo sapiens]"]
[2827,2149,0.5,2.39,2.25701061820602,2.60339965784114e-5,"Up",3.9482e-6,"GPR3","GO:0016021//integral component of membrane","GO:0004930//G-protein coupled receptor activity","GO:0007188//adenylate cyclase-modulating G-protein coupled receptor signaling pathway","K04311//G protein-coupled receptor 3","gi|817338050|ref|XP_012295201.1|//PREDICTED: G-protein coupled receptor 3 [Aotus nancymaae]"]
[10253,2332,3.19,14.23,2.15730733276161,7.28210221357466e-27,"Up",1.988318e-28,"SPRY2","GO:0001726//ruffle;GO:0016020//membrane;GO:0015630//microtubule cytoskeleton;GO:0044444//cytoplasmic part","GO:0030295//protein kinase activator activity","GO:0043405//regulation of MAP kinase activity;GO:0048869//cellular developmental process;GO:0001763//morphogenesis of a branching structure;GO:0046578//regulation of Ras protein signal transduction;GO:0008283//cell proliferation;GO:0007173//epidermal growth factor receptor signaling pathway;GO:0001934//positive regulation of protein phosphorylation;GO:0008543//fibroblast growth factor receptor signaling pathway;GO:0035265//organ growth;GO:0006915//apoptotic process;GO:0043409//negative regulation of MAPK cascade;GO:0042471//ear morphogenesis;GO:0010467//gene expression;GO:0043410//positive regulation of MAPK cascade;GO:0034260//negative regulation of GTPase activity;GO:0050954//sensory perception of mechanical stimulus","K17383//protein sprouty homolog 2","gi|5032115|ref|NP_005833.1|//protein sprouty homolog 2 [Homo sapiens]"]
[84541,4309,0.69,3,2.12029423371771,2.6556414e-13,"Up",1.54207e-14,"KBTBD8","NA","NA","NA","K10475//kelch repeat and BTB domain-containing protein 8","gi|14017901|dbj|BAB47471.1|//KIAA1842 protein [Homo sapiens];gi|227497736|ref|NP_115894.2|//kelch repeat and BTB domain-containing protein 8 [Homo sapiens]"]
[81848,5369,0.7,2.96,2.08017034868398,4.631420525e-13,"Up",2.74658e-14,"SPRY4","GO:0016020//membrane;GO:0001726//ruffle;GO:0044424//intracellular part","GO:0005488//binding","GO:0032501//multicellular organismal process;GO:0043405//regulation of MAP kinase activity","K17385//protein sprouty homolog 4","gi|676262404|gb|KFO19378.1|//Protein sprouty like protein 4 [Fukomys damarensis];gi|23308574|ref|NP_112226.2|//protein sprouty homolog 4 isoform 1 [Homo sapiens];gi|741933930|ref|XP_010805710.1|//PREDICTED: protein sprouty homolog 4 isoform X1 [Bos taurus]"]
[122481,3371,0.37,1.56,2.0759488532333,3.5783797944664e-5,"Up",5.5926e-6,"AK7","GO:0044444//cytoplasmic part","GO:0032559//adenyl ribonucleotide binding;GO:0019201//nucleotide kinase activity;GO:0016776//phosphotransferase activity, phosphate group as acceptor","GO:0034641//cellular nitrogen compound metabolic process","K00939//adenylate kinase [EC:2.7.4.3]","gi|148727333|ref|NP_689540.2|//adenylate kinase 7 [Homo sapiens];gi|578825459|ref|XP_006720085.1|//PREDICTED: adenylate kinase 7 isoform X3 [Homo sapiens];gi|694957691|ref|XP_009426695.1|//PREDICTED: adenylate kinase 7 isoform X3 [Pan troglodytes];gi|426377965|ref|XP_004055720.1|//PREDICTED: adenylate kinase 7 [Gorilla gorilla gorilla];gi|694957689|ref|XP_009426694.1|//PREDICTED: adenylate kinase 7 isoform X2 [Pan troglodytes];gi|578825457|ref|XP_006720084.1|//PREDICTED: adenylate kinase 7 isoform X1 [Homo sapiens];gi|767979652|ref|XP_011534705.1|//PREDICTED: adenylate kinase 7 isoform X2 [Homo sapiens]"]
[7422,3456,6.61,27.22,2.0419448899963,3.18700898086956e-76,"Up",2.26406e-78,"VEGFA","GO:0031012//extracellular matrix;GO:0031091//platelet alpha granule","GO:0005172//vascular endothelial growth factor receptor binding;GO:0042802//identical protein binding;GO:0005539//glycosaminoglycan binding;GO:0046983//protein dimerization activity","GO:0030154//cell differentiation;GO:0002690//positive regulation of leukocyte chemotaxis;GO:0010595//positive regulation of endothelial cell migration;GO:0043114//regulation of vascular permeability;GO:0006915//apoptotic process;GO:0001666//response to hypoxia;GO:0001775//cell activation;GO:0050927//positive regulation of positive chemotaxis;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0045765//regulation of angiogenesis;GO:0009967//positive regulation of signal transduction;GO:0001934//positive regulation of protein phosphorylation;GO:0007599//hemostasis;GO:0001935//endothelial cell proliferation;GO:0006887//exocytosis","K05448//vascular endothelial growth factor A","gi|76781487|ref|NP_001028928.1|//vascular endothelial growth factor A isoform g [Homo sapiens];gi|76781480|ref|NP_001020537.2|//vascular endothelial growth factor A isoform a [Homo sapiens];gi|194271211|gb|ACF37105.1|//vascular endothelial growth factor [Sus scrofa];gi|731453918|ref|XP_010585726.1|//PREDICTED: vascular endothelial growth factor A, partial [Loxodonta africana];gi|511831408|ref|XP_004740378.1|//PREDICTED: vascular endothelial growth factor A [Mustela putorius furo];gi|949394728|ref|NP_001303939.1|//vascular endothelial growth factor A isoform VEGF-Ax precursor [Homo sapiens];gi|927157557|ref|XP_013833429.1|//PREDICTED: vascular endothelial growth factor A isoform X1, partial [Sus scrofa]"]
[6809,2554,15.63,64.13,2.03668162883813,6.78259011235955e-92,"Up",3.729e-94,"STX3","GO:0031224//intrinsic component of membrane;GO:0030141//secretory granule;GO:0042995//cell projection;GO:0030427//site of polarized growth;GO:0043234//protein complex;GO:0005766//primary lysosome;GO:0030054//cell junction","GO:0005515//protein binding;GO:0050543//icosatetraenoic acid binding","GO:0006979//response to oxidative stress;GO:0030030//cell projection organization;GO:0015031//protein transport;GO:0016192//vesicle-mediated transport","K08486//syntaxin 1B/2/3","gi|4759184|ref|NP_004168.1|//syntaxin-3 isoform 1 [Homo sapiens];gi|830022305|ref|XP_012615285.1|//PREDICTED: syntaxin-3 isoform X1 [Microcebus murinus];gi|530397194|ref|XP_005274255.1|//PREDICTED: syntaxin-3 isoform X2 [Homo sapiens]"]
[1847,2545,6.46,26.33,2.02710145135214,1.8260567253886e-53,"Up",2.1771e-55,"DUSP5","GO:0031981//nuclear lumen","GO:0008138//protein tyrosine/serine/threonine phosphatase activity","GO:0000165//MAPK cascade;GO:0006464//cellular protein modification process;GO:0001704//formation of primary germ layer","K04459//dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]","gi|119569944|gb|EAW49559.1|//dual specificity phosphatase 5, isoform CRA_a [Homo sapiens]"]
[22822,5913,19.63,79.39,2.01589712349383,0,"Up",0,"PHLDA1","GO:0031981//nuclear lumen;GO:0012506//vesicle membrane","GO:0005488//binding","GO:0012502//induction of programmed cell death;GO:0009101//glycoprotein biosynthetic process","K12581//CCR4-NOT transcription complex subunit 7/8;K15289//solute carrier family 35, member F5;K15696//RING finger protein 113B;K17985//activating molecule in BECN1-regulated autophagy protein 1","gi|83977459|ref|NP_031376.3|//pleckstrin homology-like domain family A member 1 [Homo sapiens]"]
[148523,1165,0.91,3.66,2.00790519808535,0.000236352487652646,"Up",4.30422e-5,"CIART","NA","NA","NA","NA","gi|675742364|ref|XP_002759912.2|//PREDICTED: circadian-associated transcriptional repressor isoform X1 [Callithrix jacchus];gi|16924247|gb|AAH17397.1|//C1orf51 protein, partial [Homo sapiens];gi|21389605|ref|NP_653298.1|//circadian-associated transcriptional repressor isoform a [Homo sapiens]"]
[2669,2195,1.17,4.69,2.00307939293197,7.1963157484787e-9,"Up",6.57484e-10,"GEM","GO:0044459//plasma membrane part","GO:0046872//metal ion binding;GO:0005515//protein binding;GO:0032561//guanyl ribonucleotide binding;GO:0017111//nucleoside-triphosphatase activity","GO:0002376//immune system process;GO:0035556//intracellular signal transduction;GO:0009207//purine ribonucleoside triphosphate catabolic process","K07846//GTP binding protein overexpressed in skeletal muscle","gi|4885263|ref|NP_005252.1|//GTP-binding protein GEM [Homo sapiens];gi|197100579|ref|NP_001126848.1|//GTP-binding protein GEM [Pongo abelii]"]
[5329,1245,24.71,97.91,1.98636120578779,2.21506249666667e-111,"Up",9.85202e-114,"PLAUR","GO:0031224//intrinsic component of membrane;GO:0031090//organelle membrane;GO:0044432//endoplasmic reticulum part","GO:0005515//protein binding;GO:0004872//receptor activity","GO:0030195//negative regulation of blood coagulation;GO:0006497//protein lipidation;GO:0006508//proteolysis;GO:0042221//response to chemical;GO:0023052//signaling;GO:0042246//tissue regeneration","K03985//plasminogen activator, urokinase receptor","gi|1093472|prf||2104201A//urokinase plasminogen activator receptor;gi|53829379|ref|NP_001005376.1|//urokinase plasminogen activator surface receptor isoform 2 precursor [Homo sapiens];gi|53829381|ref|NP_001005377.1|//urokinase plasminogen activator surface receptor isoform 3 precursor [Homo sapiens];gi|530416698|ref|XP_005259047.1|//PREDICTED: urokinase plasminogen activator surface receptor isoform X2 [Homo sapiens];gi|4505865|ref|NP_002650.1|//urokinase plasminogen activator surface receptor isoform 1 precursor [Homo sapiens];gi|666335655|ref|NP_001287966.1|//urokinase plasminogen activator surface receptor isoform 4 precursor [Homo sapiens];gi|795497252|ref|XP_011709543.1|//PREDICTED: urokinase plasminogen activator surface receptor isoform X1 [Macaca nemestrina];gi|768009558|ref|XP_011525329.1|//PREDICTED: urokinase plasminogen activator surface receptor isoform X1 [Homo sapiens];gi|768009574|ref|XP_011525332.1|//PREDICTED: urokinase plasminogen activator surface receptor isoform X4 [Homo sapiens]"]
[6515,3938,13.6,53.68,1.98077802006248,5.20001201560975e-164,"Up",1.317028e-166,"SLC2A3","GO:0031224//intrinsic component of membrane","GO:0051183//vitamin transporter activity;GO:0005355//glucose transmembrane transporter activity","GO:0051180//vitamin transport;GO:0006766//vitamin metabolic process;GO:0044238//primary metabolic process;GO:0008645//hexose transport","K08142//MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 3","gi|5902090|ref|NP_008862.1|//solute carrier family 2, facilitated glucose transporter member 3 [Homo sapiens]"]
[6422,4482,12.58,49.61,1.97949903501339,1.98017012e-172,"Up",4.40364e-175,"SFRP1","GO:0031012//extracellular matrix;GO:0016020//membrane;GO:0044444//cytoplasmic part","GO:0004175//endopeptidase activity;GO:0061135//endopeptidase regulator activity;GO:0019904//protein domain specific binding;GO:0001664//G-protein coupled receptor binding;GO:0005539//glycosaminoglycan binding;GO:0004888//transmembrane signaling receptor activity","GO:0016477//cell migration;GO:0010951//negative regulation of endopeptidase activity;GO:0008589//regulation of smoothened signaling pathway;GO:0043407//negative regulation of MAP kinase activity;GO:0034695//response to prostaglandin E;GO:0002762//negative regulation of myeloid leukocyte differentiation;GO:0050796//regulation of insulin secretion;GO:0003402//planar cell polarity pathway involved in axis elongation;GO:0008406//gonad development;GO:0043065//positive regulation of apoptotic process;GO:0032355//response to estradiol;GO:0014029//neural crest formation;GO:0071363//cellular response to growth factor stimulus;GO:0070555//response to interleukin-1;GO:0033144//negative regulation of intracellular steroid hormone receptor signaling pathway;GO:0001756//somitogenesis;GO:0031669//cellular response to nutrient levels;GO:0045597//positive regulation of cell differentiation;GO:0060688//regulation of morphogenesis of a branching structure;GO:0008285//negative regulation of cell proliferation;GO:0045577//regulation of B cell differentiation;GO:0043066//negative regulation of apoptotic process;GO:0030509//BMP signaling pathway;GO:0033280//response to vitamin D;GO:0001666//response to hypoxia;GO:0060343//trabecula formation;GO:0001933//negative regulation of protein phosphorylation;GO:0019827//stem cell population maintenance;GO:0034612//response to tumor necrosis factor;GO:0060442//branching involved in prostate gland morphogenesis;GO:0051726//regulation of cell cycle;GO:0001954//positive regulation of cell-matrix adhesion;GO:0030178//negative regulation of Wnt signaling pathway;GO:0016049//cell growth;GO:0001503//ossification;GO:0034104//negative regulation of tissue remodeling;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0044343//canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation;GO:0009798//axis specification;GO:0000737//DNA catabolic process, endonucleolytic;GO:0014020//primary neural tube formation;GO:0010165//response to X-ray;GO:0007417//central nervous system development;GO:0030177//positive regulation of Wnt signaling pathway;GO:0032233//positive regulation of actin filament bundle assembly;GO:0007423//sensory organ development;GO:0010952//positive regulation of peptidase activity;GO:0008284//positive regulation of cell proliferation","K02166//secreted frizzled-related protein 1","gi|56117838|ref|NP_003003.3|//secreted frizzled-related protein 1 precursor [Homo sapiens]"]
[7128,4649,1.31,5.04,1.94385692196247,1.21991046381093e-17,"Up",5.1018e-19,"TNFAIP3","GO:0043231//intracellular membrane-bounded organelle;GO:0005815//microtubule organizing center","GO:0046914//transition metal ion binding;GO:0019787//ubiquitin-like protein transferase activity;GO:0003676//nucleic acid binding;GO:0019783//ubiquitin-like protein-specific protease activity;GO:0016790//thiolester hydrolase activity;GO:0004869//cysteine-type endopeptidase inhibitor activity;GO:0032182//ubiquitin-like protein binding;GO:0019899//enzyme binding","GO:0002158//osteoclast proliferation;GO:0043433//negative regulation of sequence-specific DNA binding transcription factor activity;GO:0032496//response to lipopolysaccharide;GO:0034122//negative regulation of toll-like receptor signaling pathway;GO:0050864//regulation of B cell activation;GO:0002507//tolerance induction;GO:0032845//negative regulation of homeostatic process;GO:0001818//negative regulation of cytokine production;GO:0016579//protein deubiquitination;GO:0000209//protein polyubiquitination;GO:0008285//negative regulation of cell proliferation;GO:0010466//negative regulation of peptidase activity;GO:0050688//regulation of defense response to virus;GO:0043066//negative regulation of apoptotic process;GO:0009896//positive regulation of catabolic process;GO:0007249//I-kappaB kinase/NF-kappaB signaling;GO:0045765//regulation of angiogenesis;GO:0002467//germinal center formation;GO:0001782//B cell homeostasis;GO:0006461//protein complex assembly;GO:0031348//negative regulation of defense response","K11859//tumor necrosis factor, alpha-induced protein 3 [EC:3.4.19.12]","gi|332213433|ref|XP_003255830.1|//PREDICTED: tumor necrosis factor alpha-induced protein 3 isoform X3 [Nomascus leucogenys];gi|820979981|ref|XP_012361594.1|//PREDICTED: tumor necrosis factor alpha-induced protein 3 isoform X1 [Nomascus leucogenys];gi|441601849|ref|XP_004087703.1|//PREDICTED: tumor necrosis factor alpha-induced protein 3 isoform X2 [Nomascus leucogenys];gi|5454132|ref|NP_006281.1|//tumor necrosis factor alpha-induced protein 3 [Homo sapiens]"]
[4502,466,67.91,260.73,1.9408606537287,1.8254297025e-85,"Up",1.082538e-87,"MT2A","NA","GO:0005488//binding","GO:0007165//signal transduction;GO:0042221//response to chemical","K14739//metallothionein 1/2","gi|635116499|ref|XP_007981228.1|//PREDICTED: metallothionein-2-like [Chlorocebus sabaeus]"]
[8995,748,1.65,6.24,1.91908000461643,0.000511242492830189,"Up",0.0001004294,"TNFSF18","GO:0031224//intrinsic component of membrane;GO:0044421//extracellular region part","GO:0032813//tumor necrosis factor receptor superfamily binding","GO:0002376//immune system process;GO:0007154//cell communication;GO:0023052//signaling;GO:0043066//negative regulation of apoptotic process","K05479//tumor necrosis factor ligand superfamily member 18","gi|157419142|ref|NP_005083.2|//tumor necrosis factor ligand superfamily member 18 [Homo sapiens]"]
[5054,2954,11.79,43.62,1.88742605166099,3.34910448571429e-100,"Up",1.73786e-102,"SERPINE1","GO:0016020//membrane;GO:0044421//extracellular region part;GO:0031091//platelet alpha granule","GO:0004866//endopeptidase inhibitor activity;GO:0019899//enzyme binding","GO:0009888//tissue development;GO:0032496//response to lipopolysaccharide;GO:0014909//smooth muscle cell migration;GO:0042742//defense response to bacterium;GO:0001819//positive regulation of cytokine production;GO:0045807//positive regulation of endocytosis;GO:0009629//response to gravity;GO:0002540//leukotriene production involved in inflammatory response;GO:0008283//cell proliferation;GO:0002548//monocyte chemotaxis;GO:0010466//negative regulation of peptidase activity;GO:0030195//negative regulation of blood coagulation;GO:0016525//negative regulation of angiogenesis;GO:0031349//positive regulation of defense response;GO:0007569//cell aging;GO:0006915//apoptotic process;GO:0032102//negative regulation of response to external stimulus;GO:0031960//response to corticosteroid;GO:0006979//response to oxidative stress;GO:0033500//carbohydrate homeostasis;GO:0001775//cell activation;GO:0001953//negative regulation of cell-matrix adhesion;GO:0010755//regulation of plasminogen activation;GO:0009966//regulation of signal transduction;GO:0030194//positive regulation of blood coagulation;GO:0006887//exocytosis","K03982//plasminogen activator inhibitor 1","gi|635139637|ref|XP_008016670.1|//PREDICTED: plasminogen activator inhibitor 1 isoform X2 [Chlorocebus sabaeus]"]
[3673,7878,2.54,9.3,1.87240221922323,5.2095792122449e-53,"Up",6.30762e-55,"ITGA2","GO:0009986//cell surface;GO:0005887//integral component of plasma membrane","GO:0005515//protein binding;GO:0004871//signal transducer activity","GO:0009653//anatomical structure morphogenesis;GO:0031589//cell-substrate adhesion;GO:0007166//cell surface receptor signaling pathway;GO:0006935//chemotaxis;GO:0007599//hemostasis;GO:0051704//multi-organism process","K06481//integrin alpha 2","gi|116295258|ref|NP_002194.2|//integrin alpha-2 precursor [Homo sapiens];gi|119575268|gb|EAW54873.1|//integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), isoform CRA_b [Homo sapiens]"]
[6792,5327,0.26,0.95,1.86941589018986,0.000486154375489577,"Up",9.50806e-5,"CDKL5","GO:0001726//ruffle;GO:0030425//dendrite;GO:0031981//nuclear lumen;GO:0030426//growth cone","GO:0017048//Rho GTPase binding;GO:0004674//protein serine/threonine kinase activity;GO:0032559//adenyl ribonucleotide binding","GO:0016477//cell migration;GO:0006468//protein phosphorylation;GO:0030307//positive regulation of cell growth;GO:0010975//regulation of neuron projection development;GO:0031346//positive regulation of cell projection organization","K08824//cyclin-dependent kinase-like [EC:2.7.11.22]","gi|4507281|ref|NP_003150.1|//cyclin-dependent kinase-like 5 [Homo sapiens];gi|307148972|gb|ADN38258.1|//cyclin dependent kinase 5 transcript variant [Homo sapiens]"]
[8482,3376,1.52,5.53,1.86320815679112,2.993594873903e-14,"Up",1.601466e-15,"SEMA7A","GO:0031224//intrinsic component of membrane;GO:0009986//cell surface","GO:0004871//signal transducer activity;GO:0005488//binding","GO:0007166//cell surface receptor signaling pathway;GO:0030307//positive regulation of cell growth;GO:0048731//system development;GO:0048869//cellular developmental process;GO:0043410//positive regulation of MAPK cascade;GO:0031347//regulation of defense response;GO:0006935//chemotaxis;GO:0010935//regulation of macrophage cytokine production","K06529//semaphorin 7","gi|225637520|ref|NP_001139501.1|//semaphorin-7A isoform 2 precursor [Homo sapiens];gi|4504237|ref|NP_003603.1|//semaphorin-7A isoform 1 preproprotein [Homo sapiens];gi|795399484|ref|XP_011755267.1|//PREDICTED: semaphorin-7A isoform X2 [Macaca nemestrina]"]
[9732,7696,0.59,2.12,1.84527740520136,1.57953372307692e-12,"Up",9.89404e-14,"DOCK4","GO:0043232//intracellular non-membrane-bounded organelle;GO:0044444//cytoplasmic part;GO:0005902//microvillus","GO:0017048//Rho GTPase binding;GO:0019904//protein domain specific binding;GO:0032561//guanyl ribonucleotide binding;GO:0005102//receptor binding","GO:0006935//chemotaxis","K17697//dedicator of cytokinesis protein 4","gi|694923597|ref|XP_009452263.1|//PREDICTED: dedicator of cytokinesis protein 4 isoform X1 [Pan troglodytes];gi|92091572|ref|NP_055520.3|//dedicator of cytokinesis protein 4 [Homo sapiens];gi|694923601|ref|XP_009452265.1|//PREDICTED: dedicator of cytokinesis protein 4 isoform X3 [Pan troglodytes];gi|578814793|ref|XP_006716252.1|//PREDICTED: dedicator of cytokinesis protein 4 isoform X3 [Homo sapiens];gi|578814791|ref|XP_006716251.1|//PREDICTED: dedicator of cytokinesis protein 4 isoform X1 [Homo sapiens];gi|694923607|ref|XP_009452268.1|//PREDICTED: dedicator of cytokinesis protein 4 isoform X6 [Pan troglodytes];gi|694923599|ref|XP_009452264.1|//PREDICTED: dedicator of cytokinesis protein 4 isoform X2 [Pan troglodytes];gi|694923603|ref|XP_009452266.1|//PREDICTED: dedicator of cytokinesis protein 4 isoform X4 [Pan troglodytes]"]
[4907,4058,1.51,5.26,1.80051424996722,2.2273339e-15,"Up",1.089726e-16,"NT5E","GO:0031224//intrinsic component of membrane;GO:0044424//intracellular part","GO:0005506//iron ion binding;GO:0008252//nucleotidase activity","GO:0046085//adenosine metabolic process;GO:0044260//cellular macromolecule metabolic process;GO:0009112//nucleobase metabolic process;GO:0009169//purine ribonucleoside monophosphate catabolic process;GO:0006213//pyrimidine nucleoside metabolic process;GO:0031348//negative regulation of defense response","K19970//5'-nucleotidase [EC:3.1.3.5]","gi|4505467|ref|NP_002517.1|//5'-nucleotidase isoform 1 preproprotein [Homo sapiens];gi|325651886|ref|NP_001191742.1|//5'-nucleotidase isoform 2 preproprotein [Homo sapiens] "]
[23645,2399,20.99,72.98,1.79779898429233,4.30931870709677e-118,"Up",1.650468e-120,"PPP1R15A","NA","GO:0005488//binding","GO:0050794//regulation of cellular process;GO:0033554//cellular response to stress;GO:0022402//cell cycle process","K14019//protein phosphatase 1 regulatory subunit 15A","gi|157674363|ref|NP_055145.3|//protein phosphatase 1 regulatory subunit 15A [Homo sapiens]"]
[8793,3569,15.11,52.41,1.79433844847309,2.68614999857143e-126,"Up",9.29234e-129,"TNFRSF10D","GO:0031224//intrinsic component of membrane","GO:0005515//protein binding;GO:0004872//receptor activity","GO:0023052//signaling;GO:0043066//negative regulation of apoptotic process","K04722//tumor necrosis factor receptor superfamily member 10","gi|18203495|sp|Q9UBN6.1|TR10D_HUMAN//RecName: Full=Tumor necrosis factor receptor superfamily member 10D; AltName: Full=Decoy receptor 2; Short=DcR2; AltName: Full=TNF-related apoptosis-inducing ligand receptor 4; Short=TRAIL receptor 4; Short=TRAIL-R4; AltName: Full=TRAIL receptor with a truncated death domain; AltName: CD_antigen=CD264; Flags: Precursor"]
[83931,3704,7.27,25.21,1.79396884893895,3.3155757038961e-64,"Up",3.15418e-66,"STK40","GO:0031981//nuclear lumen","GO:0032559//adenyl ribonucleotide binding;GO:0004672//protein kinase activity","GO:0006464//cellular protein modification process","K16312//serine/threonine-protein kinase 40 [EC:2.7.11.1]","gi|795179869|ref|XP_011844397.1|//PREDICTED: serine/threonine-protein kinase 40 isoform X1 [Mandrillus leucophaeus];gi|543173133|ref|NP_001269475.1|//serine/threonine-protein kinase 40 isoform 1 [Homo sapiens]"]
[4501,468,7.48,25.77,1.78458236197198,3.87462021415385e-8,"Up",3.88946e-9,"MT1X","NA","NA","NA","K14739//metallothionein 1/2","gi|119603291|gb|EAW82885.1|//metallothionein 1X, isoform CRA_a, partial [Homo sapiens]"]
[56135,2796,0.17,0.58,1.77051815387723,0.000384697381205444,"Up",7.33368e-5,"PCDHAC1","GO:0016021//integral component of membrane","GO:0046872//metal ion binding","GO:0016337//single organismal cell-cell adhesion;GO:0048731//system development","K16493//protocadherin alpha","gi|5456892|gb|AAD43697.1|//protocadherin alpha C1 [Homo sapiens];gi|5456986|gb|AAD43734.1|AF152473_1//protocadherin alpha C1 short form protein [Homo sapiens]"]
[4015,5229,0.82,2.76,1.75097245216009,2.11239645490196e-10,"Up",1.597216e-11,"LOX","GO:0043231//intracellular membrane-bounded organelle;GO:0044421//extracellular region part;GO:0005578//proteinaceous extracellular matrix","GO:0046872//metal ion binding;GO:0016641//oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor;GO:0046914//transition metal ion binding;GO:0016491//oxidoreductase activity","GO:0009611//response to wounding;GO:0042221//response to chemical;GO:0048731//system development;GO:0030323//respiratory tube development;GO:0001944//vasculature development;GO:0030198//extracellular matrix organization;GO:0085029//extracellular matrix assembly;GO:0009725//response to hormone;GO:0043412//macromolecule modification","K00277//protein-lysine 6-oxidase [EC:1.4.3.13]","gi|20149540|ref|NP_002308.2|//protein-lysine 6-oxidase isoform 1 preproprotein [Homo sapiens]"]
[444,3777,53.54,180.08,1.74994891781338,3.77064386e-291,"Up",2.79514e-294,"ASPH","GO:0031224//intrinsic component of membrane;GO:0016020//membrane;GO:0005783//endoplasmic reticulum;GO:0044425//membrane part;GO:0005789//endoplasmic reticulum membrane;GO:0031227//intrinsic component of endoplasmic reticulum membrane","GO:0046872//metal ion binding;GO:0016706//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0016701//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;GO:0005198//structural molecule activity;GO:0016491//oxidoreductase activity","GO:0008152//metabolic process;GO:0006464//cellular protein modification process;GO:0003012//muscle system process","K00476//aspartate beta-hydroxylase [EC:1.14.11.16]","gi|14589862|ref|NP_115856.1|//aspartyl/asparaginyl beta-hydroxylase isoform d [Homo sapiens];gi|530388445|ref|XP_005251301.1|//PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X10 [Homo sapiens];gi|530388433|ref|XP_005251295.1|//PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X3 [Homo sapiens];gi|14589860|ref|NP_115855.1|//aspartyl/asparaginyl beta-hydroxylase isoform c [Homo sapiens];gi|530388457|ref|XP_005251307.1|//PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X15 [Homo sapiens];gi|530388453|ref|XP_005251305.1|//PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X13 [Homo sapiens];gi|530388455|ref|XP_005251306.1|//PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X14 [Homo sapiens];gi|530388429|ref|XP_005251293.1|//PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X2 [Homo sapiens];gi|530388439|ref|XP_005251298.1|//PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X7 [Homo sapiens];gi|14589864|ref|NP_115857.1|//aspartyl/asparaginyl beta-hydroxylase isoform b [Homo sapiens];gi|530388435|ref|XP_005251296.1|//PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X4 [Homo sapiens];gi|530388441|ref|XP_005251299.1|//PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X8 [Homo sapiens];gi|14589866|ref|NP_004309.2|//aspartyl/asparaginyl beta-hydroxylase isoform a [Homo sapiens];gi|530388451|ref|XP_005251304.1|//PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X12 [Homo sapiens];gi|9910364|ref|NP_064549.1|//aspartyl/asparaginyl beta-hydroxylase isoform e [Homo sapiens];gi|530388449|ref|XP_005251303.1|//PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X11 [Homo sapiens];gi|530388443|ref|XP_005251300.1|//PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X9 [Homo sapiens];gi|258613943|ref|NP_001158222.1|//aspartyl/asparaginyl beta-hydroxylase isoform f [Homo sapiens];gi|530388427|ref|XP_005251292.1|//PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X1 [Homo sapiens];gi|258613955|ref|NP_001158227.1|//aspartyl/asparaginyl beta-hydroxylase isoform k [Homo sapiens];gi|530388437|ref|XP_005251297.1|//PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X6 [Homo sapiens]"]
[3667,8743,1.71,5.66,1.72680572794598,6.06320387008547e-32,"Up",1.314668e-33,"IRS1","GO:0043231//intracellular membrane-bounded organelle;GO:0005887//integral component of plasma membrane;GO:0044444//cytoplasmic part","GO:0019904//protein domain specific binding;GO:0030674//protein binding, bridging;GO:0005102//receptor binding;GO:0019901//protein kinase binding;GO:0004714//transmembrane receptor protein tyrosine kinase activity","GO:0016477//cell migration;GO:0048732//gland development;GO:0070092//regulation of glucagon secretion;GO:0043551//regulation of phosphatidylinositol 3-kinase activity;GO:0009968//negative regulation of signal transduction;GO:0050796//regulation of insulin secretion;GO:0010828//positive regulation of glucose transport;GO:0006635//fatty acid beta-oxidation;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0051259//protein oligomerization;GO:0048017//inositol lipid-mediated signaling;GO:0032868//response to insulin;GO:0070253//somatostatin secretion;GO:0033500//carbohydrate homeostasis;GO:0005979//regulation of glycogen biosynthetic process;GO:0009967//positive regulation of signal transduction;GO:0008284//positive regulation of cell proliferation","K16172//insulin receptor substrate 1","gi|5031805|ref|NP_005535.1|//insulin receptor substrate 1 [Homo sapiens]"]
[101928841,8853,0.27,0.88,1.70454411647383,2.25614023846154e-6,"Up",2.89892e-7,"LOC101928841","NA","NA","NA","K12581//CCR4-NOT transcription complex subunit 7/8;K17985//activating molecule in BECN1-regulated autophagy protein 1;K19953//TBC1 domain family member 6","gi|767979160|ref|XP_011535761.1|//PREDICTED: uncharacterized protein LOC101928841 isoform X3 [Homo sapiens]"]
[51195,3468,0.35,1.14,1.70360699721978,0.000633506671015385,"Up",0.0001271866,"RAPGEFL1","NA","GO:0030695//GTPase regulator activity","GO:0035556//intracellular signal transduction;GO:0007166//cell surface receptor signaling pathway;GO:0048731//system development","K04351//Rap guanine nucleotide exchange factor 4","gi|205829945|sp|Q9UHV5.2|RPGFL_HUMAN//RecName: Full=Rap guanine nucleotide exchange factor-like 1; AltName: Full=Link guanine nucleotide exchange factor II; Short=Link GEFII;gi|982305631|ref|XP_015293942.1|//PREDICTED: rap guanine nucleotide exchange factor-like 1 isoform X1 [Macaca fascicularis]"]
[5270,2241,40.96,129.08,1.65597786248694,9.77510192432432e-172,"Up",2.23424e-174,"SERPINE2","GO:0044421//extracellular region part;GO:0030141//secretory granule;GO:0009897//external side of plasma membrane;GO:0045202//synapse","GO:0005515//protein binding;GO:0005539//glycosaminoglycan binding;GO:0004866//endopeptidase inhibitor activity","GO:0034111//negative regulation of homotypic cell-cell adhesion;GO:0010466//negative regulation of peptidase activity;GO:0016477//cell migration;GO:0007596//blood coagulation;GO:0045687//positive regulation of glial cell differentiation;GO:0010755//regulation of plasminogen activation","K16643//glia-derived nexin","gi|530370527|ref|XP_005246698.1|//PREDICTED: glia-derived nexin isoform X2 [Homo sapiens];gi|211904156|ref|NP_001130002.1|//glia-derived nexin isoform c precursor [Homo sapiens] "]
[57476,7308,3.42,10.71,1.64689024986436,2.09746468292683e-41,"Up",3.1874e-43,"GRAMD1B","GO:0031224//intrinsic component of membrane","NA","NA","K12581//CCR4-NOT transcription complex subunit 7/8;K02927//large subunit ribosomal protein L40e;K17985//activating molecule in BECN1-regulated autophagy protein 1;K19951//TBC1 domain family member 8/9;K01064//wingless-type MMTV integration site family, member 9","gi|931580167|ref|XP_008971627.2|//PREDICTED: GRAM domain-containing protein 1B isoform X2 [Pan paniscus];gi|767970431|ref|XP_005271679.2|//PREDICTED: GRAM domain-containing protein 1B isoform X4 [Homo sapiens];gi|530398263|ref|XP_005271676.1|//PREDICTED: GRAM domain-containing protein 1B isoform X7 [Homo sapiens];gi|724961153|ref|XP_010354755.1|//PREDICTED: GRAM domain-containing protein 1B isoform X4 [Rhinopithecus roxellana];gi|931580165|ref|XP_014202521.1|//PREDICTED: GRAM domain-containing protein 1B isoform X1 [Pan paniscus];gi|931580169|ref|XP_014202522.1|//PREDICTED: GRAM domain-containing protein 1B isoform X3 [Pan paniscus];gi|144227752|ref|NP_065767.1|//GRAM domain-containing protein 1B isoform 2 [Homo sapiens];gi|767970437|ref|XP_011541231.1|//PREDICTED: GRAM domain-containing protein 1B isoform X8 [Homo sapiens];gi|578822330|ref|XP_005271681.2|//PREDICTED: GRAM domain-containing protein 1B isoform X6 [Homo sapiens];gi|767970429|ref|XP_011541229.1|//PREDICTED: GRAM domain-containing protein 1B isoform X3 [Homo sapiens];gi|725557739|ref|XP_010332721.1|//PREDICTED: GRAM domain-containing protein 1B isoform X3 [Saimiri boliviensis boliviensis];gi|966989016|ref|XP_014971481.1|//PREDICTED: GRAM domain-containing protein 1B isoform X8 [Macaca mulatta];gi|557440812|ref|NP_001273492.1|//GRAM domain-containing protein 1B isoform 1 [Homo sapiens] ;gi|578822328|ref|XP_006718955.1|//PREDICTED: GRAM domain-containing protein 1B isoform X1 [Homo sapiens];gi|767970447|ref|XP_011541235.1|//PREDICTED: GRAM domain-containing protein 1B isoform X9 [Homo sapiens];gi|767970427|ref|XP_011541228.1|//PREDICTED: GRAM domain-containing protein 1B isoform X2 [Homo sapiens]"]
[8660,7014,0.66,2.06,1.64210640782476,2.65642426229508e-9,"Up",2.3023e-10,"IRS2","GO:0016020//membrane;GO:0044444//cytoplasmic part","GO:0005515//protein binding","GO:0030888//regulation of B cell proliferation;GO:0048017//inositol lipid-mediated signaling;GO:0001783//B cell apoptotic process;GO:0009746//response to hexose;GO:0032868//response to insulin;GO:0050796//regulation of insulin secretion;GO:0010828//positive regulation of glucose transport;GO:0006635//fatty acid beta-oxidation;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0005979//regulation of glycogen biosynthetic process;GO:0010746//regulation of plasma membrane long-chain fatty acid transport;GO:0048878//chemical homeostasis;GO:0043549//regulation of kinase activity;GO:0008284//positive regulation of cell proliferation","K07187//insulin receptor substrate 2","gi|38683860|ref|NP_003740.2|//insulin receptor substrate 2 [Homo sapiens]"]
[3371,7630,0.29,0.9,1.6338721012021,0.000185429244536941,"Up",3.3024e-5,"TNC","GO:0005578//proteinaceous extracellular matrix","GO:0005515//protein binding","GO:0031103//axon regeneration;GO:0002009//morphogenesis of an epithelium;GO:0008283//cell proliferation;GO:0010467//gene expression;GO:0006950//response to stress;GO:0023052//signaling;GO:0048741//skeletal muscle fiber development","K06252//tenascin","gi|578817442|ref|XP_006717164.1|//PREDICTED: tenascin isoform X15 [Homo sapiens];gi|686731314|ref|XP_009243066.1|//PREDICTED: tenascin isoform X2 [Pongo abelii];gi|530391087|ref|XP_005252031.1|//PREDICTED: tenascin isoform X16 [Homo sapiens];gi|767957309|ref|XP_011516931.1|//PREDICTED: tenascin isoform X14 [Homo sapiens];gi|153946395|ref|NP_002151.2|//tenascin precursor [Homo sapiens];gi|767957301|ref|XP_011516928.1|//PREDICTED: tenascin isoform X9 [Homo sapiens];gi|530391085|ref|XP_005252030.1|//PREDICTED: tenascin isoform X12 [Homo sapiens];gi|530391089|ref|XP_005252032.1|//PREDICTED: tenascin isoform X18 [Homo sapiens];gi|767957307|ref|XP_011516930.1|//PREDICTED: tenascin isoform X13 [Homo sapiens];gi|686731311|ref|XP_009243065.1|//PREDICTED: tenascin isoform X1 [Pongo abelii];gi|578817436|ref|XP_006717161.1|//PREDICTED: tenascin isoform X7 [Homo sapiens];gi|767957296|ref|XP_011516926.1|//PREDICTED: tenascin isoform X6 [Homo sapiens];gi|578817434|ref|XP_006717160.1|//PREDICTED: tenascin isoform X5 [Homo sapiens];gi|578817432|ref|XP_006717159.1|//PREDICTED: tenascin isoform X1 [Homo sapiens];gi|767957299|ref|XP_011516927.1|//PREDICTED: tenascin isoform X8 [Homo sapiens];gi|530391083|ref|XP_005252029.1|//PREDICTED: tenascin isoform X4 [Homo sapiens];gi|686731316|ref|XP_009243067.1|//PREDICTED: tenascin isoform X3 [Pongo abelii]"]
[10628,2965,31.73,98.13,1.6288467388863,6.90070365538461e-168,"Up",1.662512e-170,"TXNIP","GO:0005740//mitochondrial envelope","GO:0030234//enzyme regulator activity;GO:0019899//enzyme binding","GO:0006605//protein targeting;GO:0009913//epidermal cell differentiation;GO:0009605//response to external stimulus;GO:0009746//response to hexose;GO:0043627//response to estrogen;GO:0006915//apoptotic process;GO:0000302//response to reactive oxygen species;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008283//cell proliferation;GO:0010038//response to metal ion","K20910//thioredoxin-interacting protein","gi|171184421|ref|NP_006463.3|//thioredoxin-interacting protein isoform 1 [Homo sapiens];gi|795226735|ref|XP_011806695.1|//PREDICTED: thioredoxin-interacting protein isoform X1 [Colobus angolensis palliatus];gi|928192549|ref|NP_001300901.1|//thioredoxin-interacting protein isoform 2 [Homo sapiens] "]
[3914,4265,9.03,27.85,1.62487943474654,4.51855644e-70,"Up",3.90782e-72,"LAMB3","GO:0043256//laminin complex","GO:0005515//protein binding","GO:0007044//cell-substrate junction assembly;GO:0045444//fat cell differentiation;GO:0009888//tissue development","K06244//laminin, beta 3","gi|62868215|ref|NP_000219.2|//laminin subunit beta-3 precursor [Homo sapiens]"]
[100101267,5865,1,3.08,1.62293035092018,2.90672884285714e-11,"Up",2.01108e-12,"POM121C","NA","NA","NA","K14316//nuclear pore complex protein Nup121","gi|205829304|sp|A8CG34.2|P121C_HUMAN//RecName: Full=Nuclear envelope pore membrane protein POM 121C; AltName: Full=Nuclear pore membrane protein 121-2; Short=POM121-2; AltName: Full=Pore membrane protein of 121 kDa C"]
[85450,6672,1.79,5.51,1.6220927313069,7.34671531818182e-22,"Up",2.39626e-23,"ITPRIP","GO:0016020//membrane","NA","NA","NA","gi|530394567|ref|XP_005270314.1|//PREDICTED: inositol 1,4,5-trisphosphate receptor-interacting protein isoform X1 [Homo sapiens]"]
[80380,2428,2.37,7.28,1.61905139130044,6.400161875e-11,"Up",4.5546e-12,"PDCD1LG2","GO:0031224//intrinsic component of membrane","GO:0004871//signal transducer activity","GO:0042098//T cell proliferation;GO:0031294//lymphocyte costimulation","K06708//programmed cell death 1 ligand 2","gi|724832656|ref|XP_010363386.1|//PREDICTED: programmed cell death 1 ligand 2 isoform X1 [Rhinopithecus roxellana]"]
[8061,1738,13.99,41.85,1.58083166027295,3.72006466153846e-40,"Up",5.9749e-42,"FOSL1","GO:0044464//cell part","GO:0005488//binding","GO:0050794//regulation of cellular process;GO:0009605//response to external stimulus;GO:0006355//regulation of transcription, DNA-templated;GO:0006950//response to stress;GO:0006351//transcription, DNA-templated;GO:0048522//positive regulation of cellular process;GO:0008283//cell proliferation;GO:0006952//defense response;GO:0010033//response to organic substance;GO:0051707//response to other organism;GO:0051704//multi-organism process","K04502//fos-like antigen 1","gi|795166852|ref|XP_011797853.1|//PREDICTED: fos-related antigen 1 isoform X2 [Colobus angolensis palliatus];gi|795284447|ref|XP_011820610.1|//PREDICTED: fos-related antigen 1 isoform X5 [Mandrillus leucophaeus];gi|635012141|ref|XP_007978672.1|//PREDICTED: fos-related antigen 1 isoform X1 [Chlorocebus sabaeus];gi|982293032|ref|XP_015289923.1|//PREDICTED: fos-related antigen 1 isoform X2 [Macaca fascicularis];gi|966984029|ref|XP_014969152.1|//PREDICTED: fos-related antigen 1 isoform X2 [Macaca mulatta];gi|640805553|ref|XP_008059203.1|//PREDICTED: fos-related antigen 1 isoform X2 [Tarsius syrichta]"]
[1844,1708,2.53,7.55,1.57733925951813,6.92596169322235e-8,"Up",7.19636e-9,"DUSP2","GO:0031981//nuclear lumen","GO:0008138//protein tyrosine/serine/threonine phosphatase activity;GO:0019901//protein kinase binding","GO:0000165//MAPK cascade;GO:0006464//cellular protein modification process;GO:0001704//formation of primary germ layer;GO:0006915//apoptotic process","K04459//dual specificity MAP kinase phosphatase [EC:3.1.3.16 3.1.3.48]","gi|119591794|gb|EAW71388.1|//dual specificity phosphatase 2, isoform CRA_e [Homo sapiens]"]
[56911,1852,6.86,20.38,1.570873569993,1.63966751125828e-19,"Up",6.11786e-21,"MAP3K7CL","GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part","GO:0005488//binding","NA","K04427//mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]","gi|8926227|gb|AAF81752.1|AF269162_1//c21orf7 form B [Homo sapiens];gi|9910146|ref|NP_064537.1|//MAP3K7 C-terminal-like protein isoform 1 [Homo sapiens];gi|7717312|emb|CAB90434.1|//TGF-beta-activated kinase like [Homo sapiens]"]
[100533467,5143,0.91,2.7,1.56902095685213,1.71118857135484e-8,"Up",1.638462e-9,"BIVM-ERCC5","NA","NA","NA","K10846//DNA excision repair protein ERCC-5","gi|324715041|ref|NP_001191354.1|//BIVM-ERCC5 protein [Homo sapiens]"]
[9825,4090,2.5,7.39,1.56364626948406,5.89547008403361e-17,"Up",2.6003e-18,"SPATA2","GO:0043231//intracellular membrane-bounded organelle","NA","GO:0048232//male gamete generation;GO:0048869//cellular developmental process","K17595//spermatogenesis-associated protein 2","gi|5174487|ref|NP_006029.1|//spermatogenesis-associated protein 2 [Homo sapiens]"]
[91373,3082,3.43,10.08,1.5552151573271,1.46087493554502e-14,"Up",7.61662e-16,"UAP1L1","NA","GO:0016772//transferase activity, transferring phosphorus-containing groups","NA","K00972//UDP-N-acetylglucosamine/UDP-N-acetylgalactosamine diphosphorylase [EC:2.7.7.23 2.7.7.83]","gi|578817975|ref|XP_006717380.1|//PREDICTED: UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 isoform X1 [Homo sapiens];gi|187936958|ref|NP_997192.2|//UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 [Homo sapiens]"]
[595,4304,13.69,39.58,1.53164916578961,9.31601413333333e-92,"Up",5.1794e-94,"CCND1","GO:0031981//nuclear lumen;GO:0043234//protein complex;GO:0044444//cytoplasmic part","GO:0019887//protein kinase regulator activity;GO:0016301//kinase activity;GO:0019900//kinase binding","GO:0007589//body fluid secretion;GO:0003006//developmental process involved in reproduction;GO:0051320//S phase;GO:0006984//ER-nucleus signaling pathway;GO:0051318//G1 phase;GO:0010038//response to metal ion;GO:0051384//response to glucocorticoid;GO:0050673//epithelial cell proliferation;GO:0010212//response to ionizing radiation;GO:0009411//response to UV;GO:0000077//DNA damage checkpoint;GO:0009887//animal organ morphogenesis;GO:0016055//Wnt signaling pathway;GO:0033273//response to vitamin;GO:0000079//regulation of cyclin-dependent protein serine/threonine kinase activity;GO:0030855//epithelial cell differentiation","K04503//cyclin D1","gi|16950655|ref|NP_444284.1|//G1/S-specific cyclin-D1 [Homo sapiens]"]
[8091,2173,2.38,6.84,1.52303475157795,5.37921923442809e-14,"Up",2.93418e-15,"HMGA2","GO:0043229//intracellular organelle","GO:0003677//DNA binding;GO:0005515//protein binding;GO:0043565//sequence-specific DNA binding;GO:0005488//binding","GO:0050794//regulation of cellular process;GO:0051276//chromosome organization;GO:0009968//negative regulation of signal transduction;GO:0006351//transcription, DNA-templated;GO:0032501//multicellular organismal process;GO:0006996//organelle organization;GO:0007049//cell cycle","K06245//laminin, beta 4;K12581//CCR4-NOT transcription complex subunit 7/8;K11447//histone demethylase [EC:1.14.11.-];K09283//high mobility group AT-hook protein 2","gi|940752924|ref|XP_014318211.1|//PREDICTED: uncharacterized protein LOC106698497 [Myotis lucifugus];gi|667256953|ref|XP_008566046.1|//PREDICTED: high mobility group protein HMGI-C isoform X1 [Galeopterus variegatus];gi|635066639|ref|XP_008002115.1|//PREDICTED: high mobility group protein HMGI-C isoform X6 [Chlorocebus sabaeus];gi|674032346|ref|XP_008827437.1|//PREDICTED: high mobility group protein HMGI-C [Nannospalax galili];gi|665506022|ref|NP_001287848.1|//high mobility group protein HMGI-C isoform d [Homo sapiens]"]
[11199,1447,3.82,10.97,1.52191898236744,7.25926321134369e-9,"Up",6.64132e-10,"ANXA10","GO:0043231//intracellular membrane-bounded organelle","GO:0046872//metal ion binding;GO:0005543//phospholipid binding","NA","K17097//annexin A10","gi|767930975|ref|XP_011529873.1|//PREDICTED: annexin A10 isoform X1 [Homo sapiens];gi|48762937|ref|NP_009124.2|//annexin A10 [Homo sapiens]"]
[10135,4569,23.68,67.37,1.50843721835833,2.94227692e-163,"Up",7.63378e-166,"NAMPT","GO:0044444//cytoplasmic part","GO:0016763//transferase activity, transferring pentosyl groups;GO:0005102//receptor binding","GO:0010557//positive regulation of macromolecule biosynthetic process;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008283//cell proliferation;GO:0019359//nicotinamide nucleotide biosynthetic process;GO:0009888//tissue development;GO:0007154//cell communication;GO:0009820//alkaloid metabolic process","K03462//nicotinamide phosphoribosyltransferase [EC:2.4.2.12]","gi|148704942|gb|EDL36889.1|//pre-B-cell colony-enhancing factor 1, partial [Mus musculus]"]
[3678,4267,36.5,103.51,1.50380178271109,4.17537084e-231,"Up",5.1586e-234,"ITGA5","GO:0001726//ruffle;GO:0009986//cell surface;GO:0005887//integral component of plasma membrane;GO:0043234//protein complex;GO:0005924//cell-substrate adherens junction","GO:0005172//vascular endothelial growth factor receptor binding;GO:0004871//signal transducer activity","GO:0034329//cell junction assembly;GO:0016337//single organismal cell-cell adhesion;GO:0007166//cell surface receptor signaling pathway;GO:0002376//immune system process;GO:0009967//positive regulation of signal transduction;GO:0001934//positive regulation of protein phosphorylation;GO:0048646//anatomical structure formation involved in morphogenesis;GO:0006935//chemotaxis;GO:0051704//multi-organism process;GO:0007599//hemostasis;GO:0007611//learning or memory;GO:0044319//wound healing, spreading of cells","K06484//integrin alpha 5","gi|938148811|ref|NP_002196.3|//integrin alpha-5 preproprotein [Homo sapiens]"]
[9518,1220,19.55,55.15,1.49619227828403,1.78229378823529e-34,"Up",3.55622e-36,"GDF15","GO:0044421//extracellular region part","GO:0005102//receptor binding","GO:0007154//cell communication;GO:0007178//transmembrane receptor protein serine/threonine kinase signaling pathway","K05504//growth differentiation factor 15","gi|153792495|ref|NP_004855.2|//growth/differentiation factor 15 preproprotein [Homo sapiens]"]
[3575,4574,10.59,29.8,1.49260974135719,1.60789675938462e-71,"Up",1.291244e-73,"IL7R","GO:0031224//intrinsic component of membrane;GO:0009986//cell surface","GO:0004896//cytokine receptor activity","GO:0042592//homeostatic process;GO:0007165//signal transduction;GO:0002440//production of molecular mediator of immune response;GO:0007166//cell surface receptor signaling pathway;GO:0033077//T cell differentiation in thymus;GO:0032989//cellular component morphogenesis;GO:0001911//negative regulation of leukocyte mediated cytotoxicity;GO:0040007//growth;GO:0006310//DNA recombination;GO:0042113//B cell activation","K05072//interleukin 7 receptor","gi|220683005|gb|ACL80333.1|//interleukin 7 receptor isoform H5-6 [Homo sapiens];gi|28610151|ref|NP_002176.2|//interleukin-7 receptor subunit alpha precursor [Homo sapiens]"]
[6533,5048,3.58,10.06,1.49059881254127,7.0675887751938e-11,"Up",5.06886e-12,"SLC6A6","GO:0016021//integral component of membrane","GO:0005326//neurotransmitter transporter activity;GO:0005343//organic acid:sodium symporter activity;GO:0043176//amine binding;GO:0005275//amine transmembrane transporter activity","GO:0019752//carboxylic acid metabolic process;GO:0006807//nitrogen compound metabolic process;GO:0006865//amino acid transport","K05039//solute carrier family 6 (neurotransmitter transporter, GABA) member 6/8/11/12/13","gi|795153295|ref|XP_011839020.1|//PREDICTED: sodium- and chloride-dependent taurine transporter isoform X1 [Mandrillus leucophaeus];gi|578806501|ref|XP_006713370.1|//PREDICTED: sodium- and chloride-dependent taurine transporter isoform X2 [Homo sapiens];gi|938084912|gb|KPP79628.1|//sodium- and chloride-dependent taurine transporter-like, partial [Scleropages formosus];gi|618857458|ref|NP_001127839.2|//sodium- and chloride-dependent taurine transporter isoform c [Homo sapiens]"]
[9120,3932,0.68,1.91,1.48996598678541,8.68582321864595e-5,"Up",1.45032e-5,"SLC16A6","GO:0016021//integral component of membrane","GO:0015291//secondary active transmembrane transporter activity;GO:0046943//carboxylic acid transmembrane transporter activity","GO:0046942//carboxylic acid transport","K08183//MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 6","gi|767996441|ref|XP_005257846.2|//PREDICTED: monocarboxylate transporter 7 isoform X2 [Homo sapiens]"]
[220213,3125,2.28,6.4,1.48903808072262,8.46463517557252e-11,"Up",6.16494e-12,"OTUD1","NA","NA","NA","K13716//OTU domain-containing protein 1 [EC:3.4.19.12]","gi|223941923|ref|NP_001138845.1|//OTU domain-containing protein 1 [Homo sapiens]"]
[91,3482,4.12,11.48,1.47840639949247,9.237712419778e-13,"Up",5.65516e-14,"ACVR1B","GO:0016021//integral component of membrane;GO:0043235//receptor complex","GO:0043169//cation binding;GO:0032559//adenyl ribonucleotide binding;GO:0017002//activin-activated receptor activity;GO:0019899//enzyme binding;GO:0032403//protein complex binding","GO:0007399//nervous system development;GO:0080090//regulation of primary metabolic process;GO:0016049//cell growth;GO:0043009//chordate embryonic development;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0001934//positive regulation of protein phosphorylation;GO:0012502//induction of programmed cell death;GO:0006468//protein phosphorylation;GO:0045639//positive regulation of myeloid cell differentiation;GO:0032924//activin receptor signaling pathway;GO:0031325//positive regulation of cellular metabolic process;GO:0008544//epidermis development;GO:0010604//positive regulation of macromolecule metabolic process;GO:0022402//cell cycle process;GO:0009790//embryo development;GO:0045137//development of primary sexual characteristics","K13567//activin receptor type-1B [EC:2.7.11.30]","gi|471413728|ref|XP_004388409.1|//PREDICTED: activin receptor type-1B isoform X2 [Trichechus manatus latirostris];gi|298231236|ref|NP_064733.3|//activin receptor type-1B isoform c precursor [Homo sapiens] ;gi|4757720|ref|NP_004293.1|//activin receptor type-1B isoform a precursor [Homo sapiens];gi|767975877|ref|XP_011537268.1|//PREDICTED: activin receptor type-1B isoform X1 [Homo sapiens];gi|767975879|ref|XP_011537269.1|//PREDICTED: activin receptor type-1B isoform X2 [Homo sapiens]"]
[3976,3948,3.12,8.69,1.47781014795215,2.77664358212635e-18,"Up",1.113196e-19,"LIF","GO:0044421//extracellular region part","GO:0005126//cytokine receptor binding","GO:0048771//tissue remodeling;GO:0003006//developmental process involved in reproduction;GO:0042503//tyrosine phosphorylation of Stat3 protein;GO:0002763//positive regulation of myeloid leukocyte differentiation;GO:0008283//cell proliferation;GO:0003337//mesenchymal to epithelial transition involved in metanephros morphogenesis;GO:0042508//tyrosine phosphorylation of Stat1 protein;GO:0045687//positive regulation of glial cell differentiation;GO:0001525//angiogenesis;GO:0010948//negative regulation of cell cycle process;GO:0072182//regulation of nephron tubule epithelial cell differentiation;GO:0043409//negative regulation of MAPK cascade;GO:0046887//positive regulation of hormone secretion;GO:0060706//cell differentiation involved in embryonic placenta development;GO:0048609//multicellular organismal reproductive process;GO:0033138//positive regulation of peptidyl-serine phosphorylation;GO:0010975//regulation of neuron projection development;GO:0007167//enzyme linked receptor protein signaling pathway","K05419//leukemia inhibitory factor","gi|187141|gb|AAA59517.1|//myeloid leukemia-inhibitory factor (AA at 10), partial [Homo sapiens]"]
[9201,6856,0.76,2.1,1.46631800422254,5.97334669306931e-7,"Up",7.08108e-8,"DCLK1","GO:0016021//integral component of membrane","GO:0032559//adenyl ribonucleotide binding;GO:0004672//protein kinase activity;GO:0004871//signal transducer activity","GO:0021955//central nervous system neuron axonogenesis;GO:0016477//cell migration;GO:0007165//signal transduction;GO:0048588//developmental cell growth;GO:0007420//brain development;GO:0016192//vesicle-mediated transport;GO:0006464//cellular protein modification process;GO:0051707//response to other organism","K08805//doublecortin-like kinase 1/2 [EC:2.7.11.1]","gi|817301079|ref|XP_012320992.1|//PREDICTED: serine/threonine-protein kinase DCLK1 isoform X3 [Aotus nancymaae];gi|306518606|ref|NP_001182345.1|//serine/threonine-protein kinase DCLK1 isoform 3 [Homo sapiens] ;gi|558102485|ref|XP_006083686.1|//PREDICTED: serine/threonine-protein kinase DCLK1 isoform X3 [Myotis lucifugus];gi|635024940|ref|XP_007958307.1|//PREDICTED: serine/threonine-protein kinase DCLK1 isoform X2 [Chlorocebus sabaeus];gi|344246269|gb|EGW02373.1|//hypothetical protein I79_009647 [Cricetulus griseus];gi|940716156|ref|XP_014305354.1|//PREDICTED: serine/threonine-protein kinase DCLK1 isoform X4 [Myotis lucifugus];gi|795262618|ref|XP_011919980.1|//PREDICTED: serine/threonine-protein kinase DCLK1 isoform X1 [Cercocebus atys];gi|306518604|ref|NP_001182344.1|//serine/threonine-protein kinase DCLK1 isoform 2 [Homo sapiens] "]
[7832,2718,6.44,17.78,1.46512273071515,1.57453709438669e-24,"Up",4.67848e-26,"BTG2","NA","GO:0005488//binding","GO:0009605//response to external stimulus;GO:0033554//cellular response to stress;GO:0030154//cell differentiation;GO:0008213//protein alkylation;GO:0003002//regionalization;GO:0030030//cell projection organization;GO:0009628//response to abiotic stimulus;GO:0006259//DNA metabolic process;GO:0008283//cell proliferation;GO:0009725//response to hormone;GO:0031442//positive regulation of mRNA 3'-end processing","K14443//protein Tob/BTG","gi|5802988|ref|NP_006754.1|//protein BTG2 [Homo sapiens]"]
[4071,1712,36.39,99.69,1.45390674257152,7.21730417142857e-84,"Up",4.36926e-86,"TM4SF1","GO:0016021//integral component of membrane","NA","NA","NA","gi|591320380|ref|XP_007086379.1|//PREDICTED: transmembrane 4 L6 family member 1 isoform X2 [Panthera tigris altaica];gi|795208573|ref|XP_011940895.1|//PREDICTED: transmembrane 4 L6 family member 1 isoform X2 [Cercocebus atys];gi|795287498|ref|XP_011814325.1|//PREDICTED: transmembrane 4 L6 family member 1 isoform X1 [Colobus angolensis palliatus]"]
[28962,4467,4.81,13.1,1.44545801265477,3.92515148962025e-29,"Up",9.57768e-31,"OSTM1","GO:0016020//membrane","NA","NA","K15289//solute carrier family 35, member F5;K15696//RING finger protein 113B;K17985//activating molecule in BECN1-regulated autophagy protein 1;K01064//wingless-type MMTV integration site family, member 9;K12025//tripartite motif-containing protein 52","gi|767942722|ref|XP_011534077.1|//PREDICTED: osteopetrosis-associated transmembrane protein 1 isoform X1 [Homo sapiens];gi|30025026|ref|NP_054747.2|//osteopetrosis-associated transmembrane protein 1 [Homo sapiens]"]
[57089,8564,6.32,17.14,1.4393706459354,2.35323128322581e-72,"Up",1.802574e-74,"ENTPD7","GO:0031224//intrinsic component of membrane;GO:0012506//vesicle membrane","GO:0003824//catalytic activity","NA","K14643//ectonucleoside triphosphate diphosphohydrolase 7 [EC:3.6.1.-]","gi|9966821|ref|NP_065087.1|//ectonucleoside triphosphate diphosphohydrolase 7 [Homo sapiens]"]
[2118,2332,4.69,12.71,1.43830420248958,1.46909644118343e-14,"Up",7.66856e-16,"ETV4","GO:0031981//nuclear lumen","GO:0003677//DNA binding;GO:0001071//nucleic acid binding transcription factor activity","GO:0033598//mammary gland epithelial cell proliferation;GO:0006351//transcription, DNA-templated;GO:0007411//axon guidance;GO:0060688//regulation of morphogenesis of a branching structure","K15592//ets translocation variant 4","gi|767994023|ref|XP_011522814.1|//PREDICTED: ETS translocation variant 4 isoform X2 [Homo sapiens];gi|221042426|dbj|BAH12890.1|//unnamed protein product [Homo sapiens];gi|795155500|ref|XP_011795552.1|//PREDICTED: ETS translocation variant 4 [Colobus angolensis palliatus];gi|602288|gb|AAA95991.1|//adenovirus E1A enhancer binding protein, partial [Homo sapiens]"]
[8795,4125,27.26,73.01,1.42130851777216,1.64521459304348e-143,"Up",4.67506e-146,"TNFRSF10B","GO:0031224//intrinsic component of membrane","GO:0005515//protein binding;GO:0016505//peptidase activator activity involved in apoptotic process;GO:0004871//signal transducer activity","GO:0009612//response to mechanical stimulus;GO:0007249//I-kappaB kinase/NF-kappaB signaling","K04722//tumor necrosis factor receptor superfamily member 10","gi|6319130|gb|AAF07175.1|AF192548_1//tumor necrosis factor receptor-like protein ZTNFR9 [Homo sapiens];gi|224494019|ref|NP_003833.4|//tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens]"]
[5366,1954,9.37,24.94,1.41234051217048,2.78390605714286e-23,"Up",8.54708e-25,"PMAIP1","GO:0031966//mitochondrial membrane","GO:0005488//binding","GO:0006006//glucose metabolic process;GO:0009267//cellular response to starvation;GO:0010212//response to ionizing radiation;GO:0007006//mitochondrial membrane organization;GO:0009416//response to light stimulus;GO:0010033//response to organic substance;GO:0008285//negative regulation of cell proliferation;GO:0001836//release of cytochrome c from mitochondria","K10131//phorbol-12-myristate-13-acetate-induced protein 1","gi|426386105|ref|XP_004059533.1|//PREDICTED: phorbol-12-myristate-13-acetate-induced protein 1-like isoform 2 [Gorilla gorilla gorilla]"]
[118429,3794,4.29,11.32,1.39982440533234,3.3569260096432e-12,"Up",2.15044e-13,"ANTXR2","GO:0031224//intrinsic component of membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0031090//organelle membrane","GO:0043169//cation binding;GO:0004871//signal transducer activity","NA","K20909//anthrax toxin receptor","gi|133777718|gb|AAI14375.1|//ANTXR2 protein, partial [Homo sapiens];gi|795163309|ref|XP_011797126.1|//PREDICTED: anthrax toxin receptor 2 isoform X1 [Colobus angolensis palliatus];gi|224809466|ref|NP_001139266.1|//anthrax toxin receptor 2 isoform 2 precursor [Homo sapiens];gi|62089412|dbj|BAD93150.1|//anthrax toxin receptor 2 variant [Homo sapiens]"]
[1026,2192,97.32,256.77,1.3996684280856,2.05315260705882e-259,"Up",2.15614e-262,"CDKN1A","GO:0031981//nuclear lumen;GO:0043234//protein complex;GO:0044444//cytoplasmic part","GO:0043169//cation binding;GO:0005515//protein binding;GO:0016538//cyclin-dependent protein serine/threonine kinase regulator activity","GO:0051320//S phase;GO:0009416//response to light stimulus;GO:0016049//cell growth;GO:0007050//cell cycle arrest;GO:0090398//cellular senescence;GO:0007264//small GTPase mediated signal transduction;GO:0051318//G1 phase;GO:0051384//response to glucocorticoid;GO:0030888//regulation of B cell proliferation;GO:0030330//DNA damage response, signal transduction by p53 class mediator;GO:0010212//response to ionizing radiation;GO:0007154//cell communication;GO:0009887//animal organ morphogenesis;GO:0010035//response to inorganic substance;GO:0008284//positive regulation of cell proliferation;GO:0000079//regulation of cyclin-dependent protein serine/threonine kinase activity","K06625//cyclin-dependent kinase inhibitor 1A","gi|62089348|dbj|BAD93118.1|//Cyclin-dependent kinase variant [Homo sapiens];gi|119624311|gb|EAX03906.1|//cyclin-dependent kinase inhibitor 1A (p21, Cip1), isoform CRA_b [Homo sapiens];gi|614458211|ref|NP_001278478.1|//cyclin-dependent kinase inhibitor 1 isoform 2 [Homo sapiens] "]
[898,1876,9.25,24.31,1.39402462262505,7.46138323809524e-23,"Up",2.32304e-24,"CCNE1","GO:0031981//nuclear lumen;GO:0005815//microtubule organizing center;GO:0043234//protein complex","GO:0035258//steroid hormone receptor binding;GO:0019887//protein kinase regulator activity;GO:0003712//transcription cofactor activity;GO:0016772//transferase activity, transferring phosphorus-containing groups","GO:0014070//response to organic cyclic compound;GO:0006355//regulation of transcription, DNA-templated;GO:0006259//DNA metabolic process;GO:0043627//response to estrogen;GO:0001541//ovarian follicle development;GO:0009887//animal organ morphogenesis;GO:0006464//cellular protein modification process;GO:0000082//G1/S transition of mitotic cell cycle;GO:0030518//intracellular steroid hormone receptor signaling pathway;GO:0051384//response to glucocorticoid;GO:0033273//response to vitamin;GO:0045595//regulation of cell differentiation","K06626//cyclin E","gi|826570265|gb|AKJ51805.1|//pluripotent specific cyclin E1 [Homo sapiens];gi|768011784|ref|XP_011525742.1|//PREDICTED: G1/S-specific cyclin-E1 isoform X1 [Homo sapiens];gi|564742976|gb|AHC02489.1|//cyclin E variant ex5del [Homo sapiens];gi|17318559|ref|NP_001229.1|//G1/S-specific cyclin-E1 [Homo sapiens]"]
[3099,5810,6.26,16.32,1.38240649503888,1.25901755631399e-36,"Up",2.2788e-38,"HK2","GO:0031966//mitochondrial membrane","GO:0032559//adenyl ribonucleotide binding;GO:0048029//monosaccharide binding;GO:0004396//hexokinase activity","GO:0016310//phosphorylation;GO:0007589//body fluid secretion;GO:0006007//glucose catabolic process;GO:0008645//hexose transport;GO:0006915//apoptotic process","K00844//hexokinase [EC:2.7.1.1]","gi|767914424|ref|XP_011531109.1|//PREDICTED: hexokinase-2 isoform X2 [Homo sapiens];gi|530367515|ref|XP_005264337.1|//PREDICTED: hexokinase-2 isoform X1 [Homo sapiens];gi|15553127|ref|NP_000180.2|//hexokinase-2 [Homo sapiens]"]
[9252,4543,1.98,5.1,1.36499681677925,5.20438813793104e-8,"Up",5.31434e-9,"RPS6KA5","GO:0031981//nuclear lumen","GO:0070011//peptidase activity, acting on L-amino acid peptides;GO:0032559//adenyl ribonucleotide binding;GO:0004672//protein kinase activity;GO:0046914//transition metal ion binding","GO:0000165//MAPK cascade;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0006468//protein phosphorylation;GO:0006935//chemotaxis;GO:0006351//transcription, DNA-templated;GO:0002224//toll-like receptor signaling pathway","K04445//ribosomal protein S6 kinase alpha-5 [EC:2.7.11.1]","gi|635128783|ref|XP_007985767.1|//PREDICTED: ribosomal protein S6 kinase alpha-5 isoform X2 [Chlorocebus sabaeus];gi|32528295|ref|NP_004746.2|//ribosomal protein S6 kinase alpha-5 isoform a [Homo sapiens];gi|32528297|ref|NP_872198.1|//ribosomal protein S6 kinase alpha-5 isoform b [Homo sapiens];gi|694957394|ref|XP_009426564.1|//PREDICTED: ribosomal protein S6 kinase alpha-5 isoform X2 [Pan troglodytes];gi|795386177|ref|XP_011939073.1|//PREDICTED: ribosomal protein S6 kinase alpha-5 isoform X3 [Cercocebus atys]"]
[92737,3272,1.92,4.94,1.36340473086352,8.50001563250883e-8,"Up",8.91588e-9,"DNER","GO:0005768//endosome;GO:0031224//intrinsic component of membrane;GO:0044297//cell body;GO:0043005//neuron projection","GO:0046872//metal ion binding;GO:0004872//receptor activity;GO:0005102//receptor binding","GO:0007399//nervous system development;GO:0044267//cellular protein metabolic process;GO:0016477//cell migration;GO:0048747//muscle fiber development;GO:0007166//cell surface receptor signaling pathway;GO:0016192//vesicle-mediated transport","K02599//Notch 1","gi|530371157|ref|XP_005247007.1|//PREDICTED: delta and Notch-like epidermal growth factor-related receptor isoform X1 [Homo sapiens];gi|116235485|ref|NP_620711.3|//delta and Notch-like epidermal growth factor-related receptor precursor [Homo sapiens]"]
[6446,2431,10.16,25.99,1.35505623170003,6.03925012173913e-28,"Up",1.544508e-29,"SGK1","GO:0016020//membrane;GO:0043231//intracellular membrane-bounded organelle","GO:0032559//adenyl ribonucleotide binding;GO:0004672//protein kinase activity","GO:0006464//cellular protein modification process;GO:0012501//programmed cell death;GO:0050896//response to stimulus;GO:0030001//metal ion transport","K13302//serum/glucocorticoid-regulated kinase 1 [EC:2.7.11.1]","gi|219521876|ref|NP_001137148.1|//serine/threonine-protein kinase Sgk1 isoform 2 [Homo sapiens];gi|219521878|ref|NP_001137149.1|//serine/threonine-protein kinase Sgk1 isoform 3 [Homo sapiens] ;gi|635172866|ref|NP_001278924.1|//serine/threonine-protein kinase Sgk1 isoform 5 [Homo sapiens] ;gi|675654438|ref|XP_008993347.1|//PREDICTED: serine/threonine-protein kinase Sgk1 isoform X2 [Callithrix jacchus];gi|829925397|ref|XP_012594934.1|//PREDICTED: serine/threonine-protein kinase Sgk1 isoform X1 [Microcebus murinus]"]
[2745,1127,23.39,59.79,1.35401234920779,4.6421226816e-30,"Up",1.075362e-31,"GLRX","GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part","GO:0005515//protein binding;GO:0016671//oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;GO:0015037//peptide disulfide oxidoreductase activity","GO:0019725//cellular homeostasis;GO:0006091//generation of precursor metabolites and energy;GO:0055086//nucleobase-containing small molecule metabolic process;GO:0051234//establishment of localization","K03676//glutaredoxin 3","gi|119616461|gb|EAW96055.1|//glutaredoxin (thioltransferase), isoform CRA_b [Homo sapiens];gi|799531981|pdb|4RQR|A//Chain A, Crystal Structure Of Human Glutaredoxin With Mesna"]
[9263,3341,12.4,31.63,1.35095343524316,5.96493952363636e-46,"Up",8.10654e-48,"STK17A","GO:0043231//intracellular membrane-bounded organelle","GO:0032559//adenyl ribonucleotide binding;GO:0004672//protein kinase activity","GO:0012502//induction of programmed cell death;GO:0006464//cellular protein modification process;GO:0035556//intracellular signal transduction","K08804//serine/threonine kinase 17 [EC:2.7.11.1]","gi|795389593|ref|XP_011939955.1|//PREDICTED: serine/threonine-protein kinase 17A isoform X2 [Cercocebus atys];gi|795431242|ref|XP_011760711.1|//PREDICTED: serine/threonine-protein kinase 17A [Macaca nemestrina]"]
[22934,1834,4.58,11.68,1.35062077078307,5.63191228015564e-10,"Up",4.4706e-11,"RPIA","GO:0044444//cytoplasmic part","GO:0016861//intramolecular oxidoreductase activity, interconverting aldoses and ketoses","GO:0006098//pentose-phosphate shunt","K01807//ribose 5-phosphate isomerase A [EC:5.3.1.6]","gi|94536842|ref|NP_653164.2|//ribose-5-phosphate isomerase [Homo sapiens]"]
[64859,3275,13.29,33.83,1.34796207251781,8.81284944e-54,"Up",1.034372e-55,"NABP1","GO:0043231//intracellular membrane-bounded organelle;GO:0043234//protein complex","GO:0043566//structure-specific DNA binding","GO:0000075//cell cycle checkpoint;GO:0000725//recombinational repair;GO:0009314//response to radiation","K15280//solute carrier family 35, member C2","gi|119631241|gb|EAX10836.1|//oligonucleotide/oligosaccharide-binding fold containing 2A, isoform CRA_b [Homo sapiens];gi|72534722|ref|NP_001026886.1|//SOSS complex subunit B2 isoform 1 [Homo sapiens]"]
[51175,2300,4.18,10.62,1.34520891872327,1.26240163809524e-10,"Up",9.33466e-12,"TUBE1","GO:0005813//centrosome","GO:0032561//guanyl ribonucleotide binding;GO:0017111//nucleoside-triphosphatase activity;GO:0005198//structural molecule activity","GO:0022402//cell cycle process;GO:0007017//microtubule-based process;GO:0043623//cellular protein complex assembly","K10391//tubulin epsilon","gi|931573164|ref|XP_003822260.2|//PREDICTED: tubulin epsilon chain isoform X1 [Pan paniscus];gi|7705915|ref|NP_057346.1|//tubulin epsilon chain [Homo sapiens]"]
[5128,4095,19.9,50.14,1.33319356540293,6.82978608510638e-87,"Up",3.9659e-89,"CDK17","NA","GO:0004674//protein serine/threonine kinase activity;GO:0032559//adenyl ribonucleotide binding","GO:0006464//cellular protein modification process","K15595//cyclin-dependent kinase 17 [EC:2.7.11.22]","gi|296487516|tpg|DAA29629.1|//TPA: PCTAIRE protein kinase 2-like [Bos taurus];gi|795457074|ref|XP_011888205.1|//PREDICTED: cyclin-dependent kinase 17 isoform X1 [Cercocebus atys]"]
[79669,2239,2.08,5.18,1.31636856954546,1.93582342072409e-5,"Up",2.8736e-6,"C3orf52","GO:0043231//intracellular membrane-bounded organelle;GO:0031224//intrinsic component of membrane;GO:0031090//organelle membrane","NA","NA","NA","gi|284519718|ref|NP_001165218.1|//TPA-induced transmembrane protein isoform 1 [Homo sapiens];gi|317373287|sp|Q5BVD1.2|TTMP_HUMAN//RecName: Full=TPA-induced transmembrane protein;gi|188595706|ref|NP_078892.2|//TPA-induced transmembrane protein isoform 2 [Homo sapiens]"]
[330,5239,14.88,36.99,1.31376077401596,1.89352192285714e-77,"Up",1.310072e-79,"BIRC3","GO:0043231//intracellular membrane-bounded organelle;GO:0032991//macromolecular complex;GO:0044425//membrane part","GO:0019787//ubiquitin-like protein transferase activity;GO:0046914//transition metal ion binding","GO:0007165//signal transduction;GO:0048232//male gamete generation;GO:0032446//protein modification by small protein conjugation;GO:0043066//negative regulation of apoptotic process;GO:0051259//protein oligomerization","K16060//baculoviral IAP repeat-containing protein 2/3","gi|4502139|ref|NP_001156.1|//baculoviral IAP repeat-containing protein 3 [Homo sapiens]"]
[8497,5880,1.22,3.02,1.30766740176219,1.15008616194468e-10,"Up",8.47574e-12,"PPFIA4","GO:0044424//intracellular part","GO:0005488//binding","GO:0009987//cellular process","K19931//protein lin-7;K11446//histone demethylase JARID1 [EC:1.14.11.-];K18626//trichohyalin;K16469//rootletin","gi|747811820|ref|NP_001291260.1|//liprin-alpha-4 isoform 1 [Homo sapiens];gi|747811797|ref|NP_001291261.1|//liprin-alpha-4 isoform 2 [Homo sapiens];gi|578801616|ref|XP_006711649.1|//PREDICTED: liprin-alpha-4 isoform X2 [Homo sapiens];gi|767910675|ref|XP_011508373.1|//PREDICTED: liprin-alpha-4 isoform X8 [Homo sapiens];gi|767910669|ref|XP_011508371.1|//PREDICTED: liprin-alpha-4 isoform X4 [Homo sapiens];gi|578801618|ref|XP_006711650.1|//PREDICTED: liprin-alpha-4 isoform X3 [Homo sapiens];gi|119611867|gb|EAW91461.1|//protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4, isoform CRA_c [Homo sapiens]"]
[2294,2579,2.04,5.03,1.30198924783403,5.05747904132231e-6,"Up",6.80454e-7,"FOXF1","GO:0043231//intracellular membrane-bounded organelle;GO:0043234//protein complex","GO:0000981//RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043566//structure-specific DNA binding;GO:0005515//protein binding;GO:0043565//sequence-specific DNA binding","GO:0009952//anterior/posterior pattern specification;GO:0060425//lung morphogenesis;GO:0016477//cell migration;GO:0014070//response to organic cyclic compound;GO:0034097//response to cytokine;GO:0009581//detection of external stimulus;GO:0007166//cell surface receptor signaling pathway;GO:0043009//chordate embryonic development;GO:0000122//negative regulation of transcription from RNA polymerase II promoter;GO:0030859//polarized epithelial cell differentiation;GO:0048333//mesodermal cell differentiation;GO:0048754//branching morphogenesis of an epithelial tube;GO:0033007//negative regulation of mast cell activation involved in immune response;GO:0009855//determination of bilateral symmetry;GO:0043062//extracellular structure organization;GO:0048565//digestive tract development;GO:0072132//mesenchyme morphogenesis;GO:0060644//mammary gland epithelial cell differentiation;GO:0010810//regulation of cell-substrate adhesion;GO:0051147//regulation of muscle cell differentiation;GO:0031348//negative regulation of defense response;GO:0008284//positive regulation of cell proliferation","K09399//forkhead box protein F","gi|119615830|gb|EAW95424.1|//forkhead box F1 [Homo sapiens]"]
[64866,5169,1.45,3.57,1.29987117401417,8.73090176949153e-11,"Up",6.36426e-12,"CDCP1","GO:0031224//intrinsic component of membrane","NA","NA","K06732//CUB domain-containing protein 1","gi|767924069|ref|XP_011532326.1|//PREDICTED: CUB domain-containing protein 1 isoform X1 [Homo sapiens];gi|426340221|ref|XP_004034031.1|//PREDICTED: CUB domain-containing protein 1-like [Gorilla gorilla gorilla];gi|14328879|gb|AAK02058.1|//CUB domain containing protein 1 [Homo sapiens];gi|30410805|ref|NP_073753.3|//CUB domain-containing protein 1 isoform 1 precursor [Homo sapiens]"]
[2290,3216,2.7,6.6,1.28950661719498,2.40804663976945e-9,"Up",2.06472e-10,"FOXG1","GO:0043231//intracellular membrane-bounded organelle","GO:0003677//DNA binding;GO:0001071//nucleic acid binding transcription factor activity","GO:0000278//mitotic cell cycle;GO:0016198//axon choice point recognition;GO:0003002//regionalization;GO:0006351//transcription, DNA-templated;GO:0007420//brain development;GO:0042471//ear morphogenesis;GO:0045596//negative regulation of cell differentiation;GO:0051726//regulation of cell cycle;GO:0021953//central nervous system neuron differentiation","K09385//forkhead box protein G","gi|148704849|gb|EDL36796.1|//mCG5477, partial [Mus musculus]"]
[3142,2308,1.66,4.05,1.28673866642506,0.000153151813305174,"Up",2.68782e-5,"HLX","NA","NA","NA","K09339//homeobox protein HLX1","NA"]
[4758,2088,41.35,100.48,1.28094913483299,4.68680983917526e-85,"Up",2.80838e-87,"NEU1","GO:0016020//membrane;GO:0031410//cytoplasmic vesicle;GO:0005764//lysosome","GO:0005488//binding;GO:0016997//alpha-sialidase activity","NA","K01186//sialidase-1 [EC:3.2.1.18]","gi|4557791|ref|NP_000425.1|//sialidase-1 precursor [Homo sapiens]"]
[2297,2272,4.38,10.62,1.27778099120298,3.24481757961783e-10,"Up",2.5176e-11,"FOXD1","GO:0043231//intracellular membrane-bounded organelle","GO:0003677//DNA binding;GO:0001071//nucleic acid binding transcription factor activity","GO:0007399//nervous system development;GO:0009653//anatomical structure morphogenesis;GO:0001822//kidney development;GO:0006355//regulation of transcription, DNA-templated;GO:0009888//tissue development;GO:0048468//cell development","K09397//forkhead box protein D","gi|4758392|ref|NP_004463.1|//forkhead box protein D1 [Homo sapiens]"]
[285704,4207,9.31,22.45,1.26986237206972,8.81963912079208e-36,"Up",1.650822e-37,"RGMB","GO:0031225//anchored component of membrane","GO:0005515//protein binding","GO:0007178//transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0006935//chemotaxis","K06847//RGM domain family","gi|767935772|ref|XP_011541648.1|//PREDICTED: RGM domain family member B isoform X3 [Homo sapiens];gi|795571735|ref|XP_011721695.1|//PREDICTED: RGM domain family member B isoform X1 [Macaca nemestrina];gi|641707516|ref|XP_008142739.1|//PREDICTED: RGM domain family member B [Eptesicus fuscus];gi|767935774|ref|XP_011541649.1|//PREDICTED: RGM domain family member B isoform X4 [Homo sapiens];gi|686718992|ref|XP_009239196.1|//PREDICTED: RGM domain family member B isoform X1 [Pongo abelii]"]
[9903,4568,4.97,11.91,1.26085565630183,2.15792314418605e-22,"Up",6.87848e-24,"KLHL21","GO:0000922//spindle pole;GO:0031461//cullin-RING ubiquitin ligase complex","GO:0019787//ubiquitin-like protein transferase activity","GO:0000087//mitotic M phase;GO:0032446//protein modification by small protein conjugation","K10458//kelch-like protein 21","gi|55925608|ref|NP_055666.2|//kelch-like protein 21 [Homo sapiens];gi|40788269|dbj|BAA32314.2|//KIAA0469 protein [Homo sapiens]"]
[57552,4294,7.2,17.24,1.25969096275942,8.82241751181103e-30,"Up",2.07644e-31,"NCEH1","GO:0031224//intrinsic component of membrane;GO:0043231//intracellular membrane-bounded organelle","GO:0043168//anion binding;GO:0016787//hydrolase activity","GO:0006464//cellular protein modification process;GO:0006629//lipid metabolic process","K14349//neutral cholesterol ester hydrolase 1 [EC:3.1.1.-]","gi|226423947|ref|NP_001139748.1|//neutral cholesterol ester hydrolase 1 isoform a [Homo sapiens];gi|68051721|ref|NP_065843.3|//neutral cholesterol ester hydrolase 1 isoform b [Homo sapiens]"]
[5606,2283,14.7,35.18,1.25893932774823,7.69497726458924e-32,"Up",1.677988e-33,"MAP2K3","GO:0031981//nuclear lumen;GO:0044444//cytoplasmic part","GO:0004712//protein serine/threonine/tyrosine kinase activity;GO:0032559//adenyl ribonucleotide binding","GO:0000165//MAPK cascade;GO:0006355//regulation of transcription, DNA-templated;GO:0033674//positive regulation of kinase activity;GO:0007166//cell surface receptor signaling pathway;GO:0002224//toll-like receptor signaling pathway","K04432//mitogen-activated protein kinase kinase 3 [EC:2.7.12.2]","gi|795265574|ref|XP_011856558.1|//PREDICTED: dual specificity mitogen-activated protein kinase kinase 3 isoform X2 [Mandrillus leucophaeus];gi|694967941|ref|XP_009430839.1|//PREDICTED: dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [Pan troglodytes];gi|21618349|ref|NP_659731.1|//dual specificity mitogen-activated protein kinase kinase 3 isoform B [Homo sapiens];gi|694989708|ref|XP_009439154.1|//PREDICTED: LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 3-like [Pan troglodytes];gi|795357081|ref|XP_011932635.1|//PREDICTED: dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [Cercocebus atys]"]
[7150,3734,9.18,21.93,1.25633975325979,1.10488055510204e-32,"Up",2.34108e-34,"TOP1","GO:0031981//nuclear lumen;GO:0005694//chromosome;GO:0043025//neuronal cell body","GO:0032559//adenyl ribonucleotide binding;GO:0003682//chromatin binding;GO:0003916//DNA topoisomerase activity","GO:0042221//response to chemical;GO:0009790//embryo development;GO:0006261//DNA-dependent DNA replication;GO:0008219//cell death;GO:0051704//multi-organism process;GO:0006796//phosphate-containing compound metabolic process","K03163//DNA topoisomerase I [EC:5.99.1.2]","gi|473581|gb|AAB60379.1|//DNA topoisomerase I, partial [Homo sapiens]"]
[11010,3917,7.58,18.01,1.24852842773518,6.66388142733813e-28,"Up",1.716604e-29,"GLIPR1","GO:0031224//intrinsic component of membrane","NA","GO:0006629//lipid metabolic process","K20412//peptidase inhibitor 16;K19919//cysteine-rich secretory protein","gi|24270816|gb|AAA82731.3|//glioma pathogenesis-related protein [Homo sapiens];gi|426373505|ref|XP_004053642.1|//PREDICTED: glioma pathogenesis-related protein 1 [Gorilla gorilla gorilla];gi|119617713|gb|EAW97307.1|//GLI pathogenesis-related 1 (glioma), isoform CRA_b [Homo sapiens]"]
[5209,4202,10.48,24.73,1.23862352285249,7.6541692e-33,"Up",1.617078e-34,"PFKFB3","GO:0044444//cytoplasmic part","GO:0008443//phosphofructokinase activity;GO:0019203//carbohydrate phosphatase activity;GO:0005515//protein binding;GO:0032559//adenyl ribonucleotide binding","GO:0016310//phosphorylation;GO:0006007//glucose catabolic process;GO:0006000//fructose metabolic process;GO:0006096//glycolytic process;GO:0006796//phosphate-containing compound metabolic process;GO:0007417//central nervous system development","K01103//6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 3&#160; [EC:2.7.1.105 3.1.3.46]","gi|635051482|ref|XP_008000388.1|//PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X2 [Chlorocebus sabaeus];gi|119606803|gb|EAW86397.1|//6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, isoform CRA_a, partial [Homo sapiens];gi|635051486|ref|XP_008000390.1|//PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X4 [Chlorocebus sabaeus];gi|795433009|ref|XP_011761016.1|//PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X4 [Macaca nemestrina];gi|635051484|ref|XP_008000389.1|//PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform X3 [Chlorocebus sabaeus];gi|544063393|ref|NP_001269559.1|//6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 3 [Homo sapiens] ;gi|224282149|ref|NP_001138915.1|//6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 isoform 2 [Homo sapiens] "]
[5210,3646,5.57,13.08,1.23161330815805,3.92753453414634e-18,"Up",1.591588e-19,"PFKFB4","GO:0044444//cytoplasmic part","GO:0008443//phosphofructokinase activity;GO:0005515//protein binding;GO:0019203//carbohydrate phosphatase activity;GO:0032559//adenyl ribonucleotide binding","GO:0006007//glucose catabolic process;GO:0006000//fructose metabolic process;GO:0006796//phosphate-containing compound metabolic process","K19030//6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 4 [EC:2.7.1.105 3.1.3.46]","gi|4758902|ref|NP_004558.1|//6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 isoform b [Homo sapiens];gi|953266486|ref|NP_001304063.1|//6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 isoform a [Homo sapiens] ;gi|694901552|ref|XP_009443675.1|//PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 isoform X1 [Pan troglodytes];gi|953266493|ref|NP_001304066.1|//6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 isoform e [Homo sapiens];gi|767923558|ref|XP_011532131.1|//PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 isoform X1 [Homo sapiens];gi|953266489|ref|NP_001304064.1|//6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 isoform c [Homo sapiens];gi|953266491|ref|NP_001304065.1|//6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 isoform d [Homo sapiens] ;gi|694901556|ref|XP_009443677.1|//PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 isoform X3 [Pan troglodytes]"]
[6996,3251,15.96,37.28,1.22394120843193,6.97206368e-45,"Up",9.6906e-47,"TDG","GO:0031981//nuclear lumen","GO:0000700//mismatch base pair DNA N-glycosylase activity;GO:0003690//double-stranded DNA binding","GO:0006285//base-excision repair, AP site formation","K20813//thymine-DNA glycosylase [EC:3.2.2.29]","gi|119618133|gb|EAW97727.1|//thymine-DNA glycosylase, isoform CRA_a [Homo sapiens];gi|1378107|gb|AAC50540.1|//G/T mismatch-specific thymine DNA glycosylase [Homo sapiens];gi|426373931|ref|XP_004053839.1|//PREDICTED: G/T mismatch-specific thymine DNA glycosylase, partial [Gorilla gorilla gorilla]"]
[127262,2440,5.43,12.68,1.22353064233505,4.4983467965616e-12,"Up",2.90942e-13,"TPRG1L","GO:0044459//plasma membrane part;GO:0030136//clathrin-coated vesicle","GO:0005515//protein binding","NA","K17776//metaxin","gi|38679907|ref|NP_877429.2|//tumor protein p63-regulated gene 1-like protein [Homo sapiens]"]
[123,1991,11.77,27.38,1.21800812621946,1.83366932290503e-21,"Up",6.08278e-23,"PLIN2","GO:0016020//membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part","NA","GO:0015908//fatty acid transport;GO:0010033//response to organic substance;GO:0006629//lipid metabolic process","K17284//perilipin-2","gi|34577059|ref|NP_001113.2|//perilipin-2 [Homo sapiens];gi|578816371|ref|XP_006716782.1|//PREDICTED: perilipin-2 isoform X1 [Homo sapiens]"]
[28996,15244,0.43,1,1.21759143507263,2.44021695402299e-6,"Up",3.1475e-7,"HIPK2","GO:0005815//microtubule organizing center;GO:0005635//nuclear envelope;GO:0016604//nuclear body","GO:0005515//protein binding;GO:0032559//adenyl ribonucleotide binding;GO:0004672//protein kinase activity;GO:0003712//transcription cofactor activity","GO:0030330//DNA damage response, signal transduction by p53 class mediator;GO:0008630//intrinsic apoptotic signaling pathway in response to DNA damage;GO:0008344//adult locomotory behavior;GO:0003002//regionalization;GO:0043066//negative regulation of apoptotic process;GO:0030509//BMP signaling pathway;GO:0050881//musculoskeletal movement;GO:0007179//transforming growth factor beta receptor signaling pathway;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0006464//cellular protein modification process;GO:0008283//cell proliferation;GO:0043410//positive regulation of MAPK cascade;GO:0051099//positive regulation of binding","K08826//homeodomain interacting protein kinase [EC:2.7.11.1]","gi|767947500|ref|XP_011514382.1|//PREDICTED: homeodomain-interacting protein kinase 2 isoform X4 [Homo sapiens];gi|164420685|ref|NP_073577.3|//homeodomain-interacting protein kinase 2 isoform 1 [Homo sapiens];gi|767947494|ref|XP_011514379.1|//PREDICTED: homeodomain-interacting protein kinase 2 isoform X1 [Homo sapiens];gi|164420691|ref|NP_001106710.1|//homeodomain-interacting protein kinase 2 isoform 2 [Homo sapiens];gi|767947496|ref|XP_011514380.1|//PREDICTED: homeodomain-interacting protein kinase 2 isoform X2 [Homo sapiens];gi|767947498|ref|XP_011514381.1|//PREDICTED: homeodomain-interacting protein kinase 2 isoform X3 [Homo sapiens];gi|767947502|ref|XP_011514383.1|//PREDICTED: homeodomain-interacting protein kinase 2 isoform X5 [Homo sapiens]"]
[23328,7709,0.59,1.37,1.21538903359869,0.000137807695088968,"Up",2.39214e-5,"SASH1","NA","GO:0005488//binding","NA","K06245//laminin, beta 4;K12581//CCR4-NOT transcription complex subunit 7/8;K17985//activating molecule in BECN1-regulated autophagy protein 1;K01064//wingless-type MMTV integration site family, member 9;K12025//tripartite motif-containing protein 52","gi|767942378|ref|XP_011533941.1|//PREDICTED: SAM and SH3 domain-containing protein 1 isoform X4 [Homo sapiens];gi|119568201|gb|EAW47816.1|//SAM and SH3 domain containing 1, isoform CRA_b [Homo sapiens];gi|431904245|gb|ELK09642.1|//SAM and SH3 domain-containing protein 1 [Pteropus alecto];gi|530383483|ref|XP_005266932.1|//PREDICTED: SAM and SH3 domain-containing protein 1 isoform X7 [Homo sapiens];gi|45935385|ref|NP_056093.3|//SAM and SH3 domain-containing protein 1 [Homo sapiens];gi|676285095|gb|KFO37430.1|//SAM and SH3 domain-containing protein 1 [Fukomys damarensis]"]
[55716,2595,9.66,22.41,1.21404755467462,1.33616704235294e-17,"Up",5.61276e-19,"LMBR1L","GO:0031224//intrinsic component of membrane","GO:0004871//signal transducer activity","GO:0016192//vesicle-mediated transport","K12581//CCR4-NOT transcription complex subunit 7/8;K11447//histone demethylase [EC:1.14.11.-];K17985//activating molecule in BECN1-regulated autophagy protein 1;K00858//NAD+ kinase [EC:2.7.1.23]","gi|663429530|ref|NP_001287680.1|//protein LMBR1L isoform 3 [Homo sapiens];gi|675783165|ref|XP_008949403.1|//PREDICTED: protein LMBR1L isoform X2 [Pan paniscus];gi|675783169|ref|XP_008949405.1|//PREDICTED: protein LMBR1L isoform X4 [Pan paniscus];gi|767974841|ref|XP_011536866.1|//PREDICTED: protein LMBR1L isoform X2 [Homo sapiens];gi|148746216|ref|NP_060583.2|//protein LMBR1L isoform 1 [Homo sapiens];gi|675783171|ref|XP_008949406.1|//PREDICTED: protein LMBR1L isoform X5 [Pan paniscus];gi|663429526|ref|NP_001287679.1|//protein LMBR1L isoform 2 [Homo sapiens];gi|6330225|dbj|BAA86488.1|//KIAA1174 protein [Homo sapiens]"]
[64750,4297,20.39,47.27,1.21306308934205,4.96204333150685e-67,"Up",4.47528e-69,"SMURF2","GO:0043231//intracellular membrane-bounded organelle;GO:0043234//protein complex;GO:0044425//membrane part;GO:0044444//cytoplasmic part","GO:0005515//protein binding;GO:0019787//ubiquitin-like protein transferase activity","GO:0007179//transforming growth factor beta receptor signaling pathway;GO:0016567//protein ubiquitination;GO:0019941//modification-dependent protein catabolic process","K04678//E3 ubiquitin ligase SMURF1/2 [EC:2.3.2.26]","gi|12232397|ref|NP_073576.1|//E3 ubiquitin-protein ligase SMURF2 [Homo sapiens];gi|767995608|ref|XP_011523430.1|//PREDICTED: E3 ubiquitin-protein ligase SMURF2 isoform X1 [Homo sapiens];gi|119614601|gb|EAW94195.1|//SMAD specific E3 ubiquitin protein ligase 2, isoform CRA_c [Homo sapiens]"]
[7424,2103,3.81,8.83,1.21262244015514,1.62263192430595e-7,"Up",1.769178e-8,"VEGFC","GO:0044421//extracellular region part;GO:0031091//platelet alpha granule","GO:0005172//vascular endothelial growth factor receptor binding","GO:0008217//regulation of blood pressure;GO:0002009//morphogenesis of an epithelium;GO:0002690//positive regulation of leukocyte chemotaxis;GO:0010595//positive regulation of endothelial cell migration;GO:0007405//neuroblast proliferation;GO:0001775//cell activation;GO:0050927//positive regulation of positive chemotaxis;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0001934//positive regulation of protein phosphorylation;GO:0048646//anatomical structure formation involved in morphogenesis;GO:0009966//regulation of signal transduction;GO:0007599//hemostasis;GO:0006887//exocytosis;GO:0008284//positive regulation of cell proliferation","K05449//vascular endothelial growth factor C/D","gi|4885653|ref|NP_005420.1|//vascular endothelial growth factor C preproprotein [Homo sapiens]"]
[129303,1788,1.68,3.88,1.20759541940837,0.000741765003640777,"Up",0.000151029,"TMEM150A","GO:0031224//intrinsic component of membrane","NA","GO:0008152//metabolic process","NA","gi|72534762|ref|NP_001026908.1|//transmembrane protein 150A precursor [Homo sapiens];gi|767913728|ref|XP_011530808.1|//PREDICTED: transmembrane protein 150A isoform X3 [Homo sapiens]"]
[55691,5180,2.46,5.68,1.20723261416544,2.18258452890173e-9,"Up",1.86601e-10,"FRMD4A","GO:0043232//intracellular non-membrane-bounded organelle","NA","NA","K05762//radixin;K05763//moesin","gi|530392249|ref|XP_005252552.1|//PREDICTED: FERM domain-containing protein 4A isoform X17 [Homo sapiens];gi|578818455|ref|XP_006717527.1|//PREDICTED: FERM domain-containing protein 4A isoform X16 [Homo sapiens];gi|578818442|ref|XP_006717522.1|//PREDICTED: FERM domain-containing protein 4A isoform X4 [Homo sapiens];gi|635051762|ref|XP_008000522.1|//PREDICTED: FERM domain-containing protein 4A isoform X9 [Chlorocebus sabaeus];gi|578818438|ref|XP_006717520.1|//PREDICTED: FERM domain-containing protein 4A isoform X2 [Homo sapiens];gi|578818444|ref|XP_006717523.1|//PREDICTED: FERM domain-containing protein 4A isoform X5 [Homo sapiens];gi|530392237|ref|XP_005252546.1|//PREDICTED: FERM domain-containing protein 4A isoform X9 [Homo sapiens];gi|635051760|ref|XP_008000521.1|//PREDICTED: FERM domain-containing protein 4A isoform X8 [Chlorocebus sabaeus];gi|767960207|ref|XP_011517843.1|//PREDICTED: FERM domain-containing protein 4A isoform X8 [Homo sapiens];gi|635051750|ref|XP_008000516.1|//PREDICTED: FERM domain-containing protein 4A isoform X3 [Chlorocebus sabaeus];gi|530392239|ref|XP_005252547.1|//PREDICTED: FERM domain-containing protein 4A isoform X10 [Homo sapiens];gi|119606679|gb|EAW86273.1|//hCG2039963, partial [Homo sapiens];gi|530392247|ref|XP_005252551.1|//PREDICTED: FERM domain-containing protein 4A isoform X15 [Homo sapiens]"]
[160760,3748,1.27,2.93,1.20607216765008,8.33169249758634e-5,"Up",1.386042e-5,"PPTC7","GO:0043231//intracellular membrane-bounded organelle","GO:0043169//cation binding;GO:0016791//phosphatase activity","NA","K17508//protein phosphatase PTC7 [EC:3.1.3.16]","gi|472352461|ref|XP_004395906.1|//PREDICTED: protein phosphatase PTC7 homolog [Odobenus rosmarus divergens]"]
[4609,2379,31,71.38,1.20325168588742,1.36811812981132e-62,"Up",1.343778e-64,"MYC","GO:0031981//nuclear lumen;GO:0015630//microtubule cytoskeleton","GO:0001071//nucleic acid binding transcription factor activity","GO:0006875//cellular metal ion homeostasis;GO:0022402//cell cycle process;GO:0006355//regulation of transcription, DNA-templated;GO:0042221//response to chemical;GO:0002053//positive regulation of mesenchymal cell proliferation;GO:0000723//telomere maintenance;GO:0048754//branching morphogenesis of an epithelial tube","K04377//Myc proto-oncogene protein","gi|71774083|ref|NP_002458.2|//myc proto-oncogene protein [Homo sapiens]"]
[7037,5117,52.12,119.83,1.20108014976739,2.56754924727273e-226,"Up",3.48938e-229,"TFRC","GO:0012505//endomembrane system;GO:0016021//integral component of membrane;GO:0048770//pigment granule","GO:0016787//hydrolase activity;GO:0031072//heat shock protein binding;GO:0004888//transmembrane signaling receptor activity","GO:0032502//developmental process;GO:0002526//acute inflammatory response;GO:0016192//vesicle-mediated transport;GO:0006875//cellular metal ion homeostasis;GO:0019538//protein metabolic process;GO:0010038//response to metal ion;GO:0051704//multi-organism process;GO:0033189//response to vitamin A;GO:0015031//protein transport","K06503//transferrin receptor","gi|189458817|ref|NP_003225.2|//transferrin receptor protein 1 isoform 1 [Homo sapiens];gi|62088088|dbj|BAD92491.1|//transferrin receptor variant [Homo sapiens]"]
[5163,3981,7.74,17.77,1.19903820988427,3.98266496363636e-29,"Up",9.74262e-31,"PDK1","GO:0044429//mitochondrial part","GO:0032559//adenyl ribonucleotide binding;GO:0004673//protein histidine kinase activity","GO:0006468//protein phosphorylation;GO:0035556//intracellular signal transduction;GO:0006086//acetyl-CoA biosynthetic process from pyruvate;GO:0019318//hexose metabolic process","K12077//pyruvate dehydrogenase kinase isoform 1 [EC:2.7.11.2]","gi|426337723|ref|XP_004032847.1|//PREDICTED: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial isoform 1 [Gorilla gorilla gorilla];gi|514052656|ref|NP_001265478.1|//[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 1 precursor [Homo sapiens];gi|4505689|ref|NP_002601.1|//[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial isoform 2 precursor [Homo sapiens];gi|578804492|ref|XP_006712658.1|//PREDICTED: pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X5 [Homo sapiens];gi|426337725|ref|XP_004032848.1|//PREDICTED: [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 1, mitochondrial isoform 2 [Gorilla gorilla gorilla];gi|578804490|ref|XP_006712657.1|//PREDICTED: pyruvate dehydrogenase (acetyl-transferring) kinase isozyme 1, mitochondrial isoform X4 [Homo sapiens]"]
[201164,2591,3.76,8.63,1.19862789750132,8.83649819920319e-9,"Up",8.22076e-10,"PLD6","GO:0031224//intrinsic component of membrane","GO:0004620//phospholipase activity","GO:0006629//lipid metabolic process","K16862//mitochondrial cardiolipin hydrolase [EC:3.1.4.-]","gi|119576122|gb|EAW55718.1|//similar to CG12314 gene product, partial [Homo sapiens];gi|641728584|ref|XP_008154444.1|//PREDICTED: LOW QUALITY PROTEIN: mitochondrial cardiolipin hydrolase [Eptesicus fuscus]"]
[4734,6081,7.41,16.95,1.19373982571787,9.8611048e-38,"Up",1.73611e-39,"NEDD4","GO:0044459//plasma membrane part;GO:0043234//protein complex;GO:0044444//cytoplasmic part;GO:0044427//chromosomal part","GO:0016597//amino acid binding;GO:0045309//protein phosphorylated amino acid binding;GO:0008200//ion channel inhibitor activity;GO:0019787//ubiquitin-like protein transferase activity;GO:0019899//enzyme binding;GO:0032182//ubiquitin-like protein binding;GO:0031690//adrenergic receptor binding","GO:0002028//regulation of sodium ion transport;GO:0009968//negative regulation of signal transduction;GO:0048731//system development;GO:0032388//positive regulation of intracellular transport;GO:0000122//negative regulation of transcription from RNA polymerase II promoter;GO:0006623//protein targeting to vacuole;GO:0031958//corticosteroid receptor signaling pathway;GO:0010038//response to metal ion;GO:0051704//multi-organism process;GO:0000209//protein polyubiquitination;GO:0009411//response to UV;GO:0030030//cell projection organization;GO:0009057//macromolecule catabolic process;GO:0009896//positive regulation of catabolic process;GO:0006898//receptor-mediated endocytosis;GO:0009967//positive regulation of signal transduction;GO:0010769//regulation of cell morphogenesis involved in differentiation","K10591//E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]","gi|547234945|ref|NP_001271267.1|//E3 ubiquitin-protein ligase NEDD4 isoform 3 [Homo sapiens];gi|114520607|ref|NP_940682.2|//E3 ubiquitin-protein ligase NEDD4 isoform 2 [Homo sapiens];gi|547235493|ref|NP_001271269.1|//E3 ubiquitin-protein ligase NEDD4 isoform 5 [Homo sapiens];gi|114520609|ref|NP_006145.2|//E3 ubiquitin-protein ligase NEDD4 isoform 1 [Homo sapiens];gi|547235255|ref|NP_001271268.1|//E3 ubiquitin-protein ligase NEDD4 isoform 4 [Homo sapiens];gi|767984288|ref|XP_011519926.1|//PREDICTED: E3 ubiquitin-protein ligase NEDD4 isoform X1 [Homo sapiens];gi|767984294|ref|XP_011519929.1|//PREDICTED: E3 ubiquitin-protein ligase NEDD4 isoform X3 [Homo sapiens]"]
[79720,2699,9,20.57,1.1925448873079,8.80517243773585e-22,"Up",2.88284e-23,"VPS37B","GO:0005768//endosome;GO:0005770//late endosome;GO:0031090//organelle membrane","NA","GO:0006810//transport;GO:0009987//cellular process;GO:0016192//vesicle-mediated transport","K12185//ESCRT-I complex subunit VPS37","gi|767975328|ref|XP_011537047.1|//PREDICTED: vacuolar protein sorting-associated protein 37B isoform X4 [Homo sapiens];gi|767975332|ref|XP_011537048.1|//PREDICTED: vacuolar protein sorting-associated protein 37B isoform X6 [Homo sapiens];gi|13375926|ref|NP_078943.1|//vacuolar protein sorting-associated protein 37B [Homo sapiens];gi|767975324|ref|XP_011537045.1|//PREDICTED: vacuolar protein sorting-associated protein 37B isoform X2 [Homo sapiens];gi|767975322|ref|XP_011537044.1|//PREDICTED: vacuolar protein sorting-associated protein 37B isoform X1 [Homo sapiens]"]
[63935,2740,1.76,4.02,1.19162007254163,0.00024965408232511,"Up",4.56342e-5,"PCIF1","GO:0043231//intracellular membrane-bounded organelle","NA","NA","K17584//phosphorylated CTD-interacting factor 1","gi|826282767|ref|XP_012495916.1|//PREDICTED: phosphorylated CTD-interacting factor 1 isoform X1 [Propithecus coquereli];gi|823471157|ref|XP_012425666.1|//PREDICTED: phosphorylated CTD-interacting factor 1 [Taeniopygia guttata];gi|955517151|ref|XP_014642896.1|//PREDICTED: phosphorylated CTD-interacting factor 1 isoform X1 [Ceratotherium simum simum];gi|344241581|gb|EGV97684.1|//Phosphorylated CTD-interacting factor 1 [Cricetulus griseus]"]
[837,1319,38.75,88.37,1.18936037374426,8.06500937427386e-42,"Up",1.200684e-43,"CASP4","GO:0044464//cell part","GO:0004175//endopeptidase activity;GO:0005488//binding","GO:0012502//induction of programmed cell death;GO:0019538//protein metabolic process;GO:0006915//apoptotic process","K04394//caspase 4 [EC:3.4.22.57]","gi|4502577|ref|NP_001216.1|//caspase-4 isoform alpha precursor [Homo sapiens]"]
[80315,7745,2.82,6.43,1.18912357492915,2.87214377631954e-17,"Up",1.243744e-18,"CPEB4","NA","GO:0005488//binding;GO:0003676//nucleic acid binding","NA","K02602//cytoplasmic polyadenylation element-binding protein","gi|767938656|ref|XP_011532963.1|//PREDICTED: cytoplasmic polyadenylation element-binding protein 4 isoform X5 [Homo sapiens];gi|189027090|ref|NP_085130.2|//cytoplasmic polyadenylation element-binding protein 4 isoform a [Homo sapiens];gi|815891022|ref|NP_001295118.1|//cytoplasmic polyadenylation element-binding protein 4 isoform b [Homo sapiens];gi|114603431|ref|XP_001155372.1|//PREDICTED: cytoplasmic polyadenylation element-binding protein 4 isoform X2 [Pan troglodytes];gi|767938654|ref|XP_011532962.1|//PREDICTED: cytoplasmic polyadenylation element-binding protein 4 isoform X4 [Homo sapiens];gi|815891024|ref|NP_001295120.1|//cytoplasmic polyadenylation element-binding protein 4 isoform c [Homo sapiens]"]
[3162,1606,11.45,26.07,1.18704298455125,2.13511933367089e-15,"Up",1.041972e-16,"HMOX1","GO:0031981//nuclear lumen;GO:0044421//extracellular region part;GO:0044459//plasma membrane part;GO:0031090//organelle membrane;GO:0044444//cytoplasmic part","GO:0004620//phospholipase activity;GO:0016705//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen;GO:0060089//molecular transducer activity;GO:0042802//identical protein binding;GO:0005506//iron ion binding","GO:0014070//response to organic cyclic compound;GO:0006355//regulation of transcription, DNA-templated;GO:0042108//positive regulation of cytokine biosynthetic process;GO:0055114//oxidation-reduction process;GO:0000302//response to reactive oxygen species;GO:0034381//plasma lipoprotein particle clearance;GO:0007584//response to nutrient;GO:0051259//protein oligomerization;GO:0008285//negative regulation of cell proliferation;GO:0042311//vasodilation;GO:0033007//negative regulation of mast cell activation involved in immune response;GO:0050673//epithelial cell proliferation;GO:0048872//homeostasis of number of cells;GO:0006810//transport;GO:0002719//negative regulation of cytokine production involved in immune response;GO:0006787//porphyrin-containing compound catabolic process;GO:0006954//inflammatory response;GO:0014805//smooth muscle adaptation;GO:0048545//response to steroid hormone;GO:0006875//cellular metal ion homeostasis;GO:0007249//I-kappaB kinase/NF-kappaB signaling;GO:0045765//regulation of angiogenesis;GO:0043392//negative regulation of DNA binding;GO:0034599//cellular response to oxidative stress;GO:0008284//positive regulation of cell proliferation","K00510//heme oxygenase (biliverdin-producing) [EC:1.14.14.18]","gi|4504437|ref|NP_002124.1|//heme oxygenase 1 [Homo sapiens]"]
[9180,3883,6.51,14.72,1.17704822289138,1.98244653946524e-13,"Up",1.145038e-14,"OSMR","GO:0005887//integral component of plasma membrane","GO:0004896//cytokine receptor activity","GO:0007165//signal transduction;GO:0008283//cell proliferation;GO:0010033//response to organic substance;GO:0002526//acute inflammatory response","K05057//oncostatin M receptor","gi|4557040|ref|NP_003990.1|//oncostatin-M-specific receptor subunit beta isoform 1 precursor [Homo sapiens];gi|530378992|ref|XP_005248444.1|//PREDICTED: oncostatin-M-specific receptor subunit beta isoform X4 [Homo sapiens];gi|767934739|ref|XP_011512463.1|//PREDICTED: oncostatin-M-specific receptor subunit beta isoform X2 [Homo sapiens];gi|530378986|ref|XP_005248441.1|//PREDICTED: oncostatin-M-specific receptor subunit beta isoform X1 [Homo sapiens];gi|530378990|ref|XP_005248443.1|//PREDICTED: oncostatin-M-specific receptor subunit beta isoform X3 [Homo sapiens];gi|270288820|ref|NP_001161827.1|//oncostatin-M-specific receptor subunit beta isoform 2 precursor [Homo sapiens]"]
[84803,2579,5.65,12.68,1.16623197283686,4.82496438174274e-13,"Up",2.87328e-14,"GPAT3","GO:0031224//intrinsic component of membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0031090//organelle membrane","GO:0008374//O-acyltransferase activity","GO:0006641//triglyceride metabolic process;GO:0006644//phospholipid metabolic process;GO:0009966//regulation of signal transduction","K13506//glycerol-3-phosphate O-acyltransferase 3/4 [EC:2.3.1.15]","gi|21362092|ref|NP_116106.2|//glycerol-3-phosphate acyltransferase 3 [Homo sapiens];gi|635043457|ref|XP_007997305.1|//PREDICTED: glycerol-3-phosphate acyltransferase 3 isoform X1 [Chlorocebus sabaeus]"]
[6744,4520,72,161.41,1.16466115048897,2.75845580290909e-291,"Up",1.874414e-294,"SSFA2","GO:0016020//membrane;GO:0044424//intracellular part","GO:0008092//cytoskeletal protein binding","NA","NA","gi|194363771|ref|NP_001123917.1|//sperm-specific antigen 2 isoform 1 [Homo sapiens];gi|767919425|ref|XP_011510003.1|//PREDICTED: sperm-specific antigen 2 isoform X3 [Homo sapiens];gi|966977212|ref|XP_014965964.1|//PREDICTED: sperm-specific antigen 2 isoform X5 [Macaca mulatta];gi|530370876|ref|XP_005246870.1|//PREDICTED: sperm-specific antigen 2 isoform X2 [Homo sapiens];gi|566559802|ref|NP_001274432.1|//sperm-specific antigen 2 isoform 3 [Homo sapiens];gi|28557788|ref|NP_006742.2|//sperm-specific antigen 2 isoform 2 [Homo sapiens];gi|530370874|ref|XP_005246869.1|//PREDICTED: sperm-specific antigen 2 isoform X1 [Homo sapiens];gi|767919428|ref|XP_011510004.1|//PREDICTED: sperm-specific antigen 2 isoform X4 [Homo sapiens]"]
[7803,3723,8.86,19.8,1.16012182641195,7.37566015203145e-16,"Up",3.47642e-17,"PTP4A1","GO:0005768//endosome;GO:0044459//plasma membrane part;GO:0015630//microtubule cytoskeleton","GO:0004725//protein tyrosine phosphatase activity;GO:0005488//binding","GO:0016477//cell migration;GO:0006470//protein dephosphorylation;GO:0032501//multicellular organismal process","K18041//protein tyrosine phosphatase type IVA [EC:3.1.3.48]","gi|148682476|gb|EDL14423.1|//protein tyrosine phosphatase 4a1, isoform CRA_b, partial [Mus musculus]"]
[4520,7596,2.05,4.58,1.1597236885915,7.33533785854969e-6,"Up",1.012302e-6,"MTF1","GO:0043231//intracellular membrane-bounded organelle","GO:0046914//transition metal ion binding;GO:0003712//transcription cofactor activity;GO:0001071//nucleic acid binding transcription factor activity;GO:0003676//nucleic acid binding","GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0006950//response to stress;GO:0010038//response to metal ion","K20828//zinc finger protein 143/76","gi|112790163|ref|NP_005946.2|//metal regulatory transcription factor 1 [Homo sapiens];gi|767904408|ref|XP_011539795.1|//PREDICTED: metal regulatory transcription factor 1 isoform X2 [Homo sapiens]"]
[8614,5361,2.89,6.45,1.15822966780994,1.49676393590504e-12,"Up",9.34784e-14,"STC2","NA","GO:0005102//receptor binding","GO:0007165//signal transduction;GO:0003006//developmental process involved in reproduction;GO:0007275//multicellular organism development;GO:0007154//cell communication;GO:0009725//response to hormone;GO:0033273//response to vitamin;GO:0001666//response to hypoxia","NA","gi|4507267|ref|NP_003705.1|//stanniocalcin-2 precursor [Homo sapiens]"]
[4209,5962,2.62,5.82,1.15145234137083,1.57610075419546e-12,"Up",9.8628e-14,"MEF2D","GO:0031981//nuclear lumen","GO:0003677//DNA binding;GO:0001071//nucleic acid binding transcription factor activity","GO:0048513//animal organ development;GO:0030154//cell differentiation;GO:0012501//programmed cell death;GO:0006351//transcription, DNA-templated;GO:0001503//ossification","K09262//MADS-box transcription enhancer factor 2D","gi|729733000|ref|XP_010562413.1|//PREDICTED: myocyte-specific enhancer factor 2D isoform X3 [Haliaeetus leucocephalus];gi|578800964|ref|XP_006711397.1|//PREDICTED: myocyte-specific enhancer factor 2D isoform X4 [Homo sapiens];gi|578800960|ref|XP_006711395.1|//PREDICTED: myocyte-specific enhancer factor 2D isoform X3 [Homo sapiens];gi|931564737|ref|XP_014202931.1|//PREDICTED: myocyte-specific enhancer factor 2D [Pan paniscus]"]
[90874,5151,2.79,6.18,1.14734171607519,5.99547213913044e-11,"Up",4.2592e-12,"ZNF697","GO:0043231//intracellular membrane-bounded organelle","GO:0046914//transition metal ion binding;GO:0003676//nucleic acid binding","NA","K09228//KRAB domain-containing zinc finger protein","gi|686702640|ref|XP_002810395.2|//PREDICTED: zinc finger protein 697 isoform X1 [Pongo abelii];gi|767906709|ref|XP_011540717.1|//PREDICTED: zinc finger protein 697 isoform X2 [Homo sapiens]"]
[10602,5678,7.4,16.39,1.14721867858315,3.9595848e-32,"Up",8.51208e-34,"CDC42EP3","GO:0005856//cytoskeleton","GO:0008092//cytoskeletal protein binding","GO:0023052//signaling;GO:0065007//biological regulation","NA","gi|3834633|gb|AAC71773.1|//MSE55-related protein [Homo sapiens]"]
[9859,7428,23.7,52.47,1.14660573085719,5.29520272e-132,"Up",1.668244e-134,"CEP170","GO:0015630//microtubule cytoskeleton;GO:0044430//cytoskeletal part;GO:0005813//centrosome","NA","NA","K16463//centrosomal protein CEP170","gi|767912850|ref|XP_011542641.1|//PREDICTED: centrosomal protein of 170 kDa isoform X4 [Homo sapiens];gi|694892498|ref|XP_009440047.1|//PREDICTED: centrosomal protein of 170 kDa isoform X3 [Pan troglodytes];gi|767912856|ref|XP_011542644.1|//PREDICTED: centrosomal protein of 170 kDa isoform X7 [Homo sapiens];gi|694892504|ref|XP_009440051.1|//PREDICTED: centrosomal protein of 170 kDa isoform X6 [Pan troglodytes];gi|767912852|ref|XP_011542642.1|//PREDICTED: centrosomal protein of 170 kDa isoform X5 [Homo sapiens];gi|767912848|ref|XP_011542640.1|//PREDICTED: centrosomal protein of 170 kDa isoform X3 [Homo sapiens];gi|694892500|ref|XP_009440049.1|//PREDICTED: centrosomal protein of 170 kDa isoform X4 [Pan troglodytes];gi|578802413|ref|XP_006711906.1|//PREDICTED: centrosomal protein of 170 kDa isoform X1 [Homo sapiens];gi|767912854|ref|XP_011542643.1|//PREDICTED: centrosomal protein of 170 kDa isoform X6 [Homo sapiens];gi|767912858|ref|XP_011542645.1|//PREDICTED: centrosomal protein of 170 kDa isoform X8 [Homo sapiens];gi|767912846|ref|XP_011542639.1|//PREDICTED: centrosomal protein of 170 kDa isoform X2 [Homo sapiens];gi|109255228|ref|NP_055627.2|//centrosomal protein of 170 kDa isoform alpha [Homo sapiens];gi|109255230|ref|NP_001035863.1|//centrosomal protein of 170 kDa isoform beta [Homo sapiens];gi|694892502|ref|XP_009440050.1|//PREDICTED: centrosomal protein of 170 kDa isoform X5 [Pan troglodytes];gi|694892512|ref|XP_009440054.1|//PREDICTED: centrosomal protein of 170 kDa isoform X11 [Pan troglodytes];gi|109255232|ref|NP_001035864.1|//centrosomal protein of 170 kDa isoform gamma [Homo sapiens];gi|767912860|ref|XP_011542646.1|//PREDICTED: centrosomal protein of 170 kDa isoform X9 [Homo sapiens]"]
[4097,5099,7.61,16.84,1.14592377956285,2.07184043171356e-29,"Up",5.00426e-31,"MAFG","NA","NA","NA","K09037//transcription factor MAFF/G/K","gi|817276047|ref|XP_012308128.1|//PREDICTED: transcription factor MafG isoform X1 [Aotus nancymaae]"]
[388,2387,45.24,99.96,1.14375197209688,6.8212185e-81,"Up",4.3823e-83,"RHOB","GO:0005770//late endosome;GO:0031090//organelle membrane","GO:0032561//guanyl ribonucleotide binding;GO:0017111//nucleoside-triphosphatase activity","GO:0007041//lysosomal transport;GO:0048869//cellular developmental process;GO:0006915//apoptotic process;GO:0001775//cell activation;GO:0045765//regulation of angiogenesis;GO:0006935//chemotaxis;GO:0051726//regulation of cell cycle;GO:0009966//regulation of signal transduction;GO:0007265//Ras protein signal transduction;GO:0007599//hemostasis;GO:0009207//purine ribonucleoside triphosphate catabolic process","K07856//Ras homolog gene family, member B","gi|625274124|ref|XP_007628644.1|//PREDICTED: rho-related GTP-binding protein RhoB isoform X2 [Cricetulus griseus]"]
[7378,1397,12.71,28.08,1.1435789052996,1.55428794071146e-12,"Up",9.7167e-14,"UPP1","GO:0044444//cytoplasmic part","GO:0016763//transferase activity, transferring pentosyl groups","GO:0009112//nucleobase metabolic process;GO:0008655//pyrimidine-containing compound salvage;GO:0046131//pyrimidine ribonucleoside metabolic process;GO:0009117//nucleotide metabolic process","K00757//uridine phosphorylase [EC:2.4.2.3]","gi|226192663|pdb|3EUE|A//Chain A, Crystal Structure Of Ligand-Free Human Uridine Phosphorylase 1 (Hupp1);gi|694920963|ref|XP_009451324.1|//PREDICTED: uridine phosphorylase 1 isoform X2 [Pan troglodytes];gi|694920967|ref|XP_009451326.1|//PREDICTED: uridine phosphorylase 1 isoform X4 [Pan troglodytes];gi|4507839|ref|NP_003355.1|//uridine phosphorylase 1 isoform a [Homo sapiens];gi|566006090|ref|NP_001274357.1|//uridine phosphorylase 1 isoform b [Homo sapiens]"]
[9590,8257,4.23,9.32,1.13967229153433,6.66078897345133e-26,"Up",1.85982e-27,"AKAP12","GO:0016020//membrane;GO:0043232//intracellular non-membrane-bounded organelle;GO:0044444//cytoplasmic part","GO:0019899//enzyme binding","GO:0006886//intracellular protein transport;GO:0010737//protein kinase A signaling;GO:0007166//cell surface receptor signaling pathway;GO:0006171//cAMP biosynthetic process","K16528//A-kinase anchor protein 12","gi|21493022|ref|NP_005091.2|//A-kinase anchor protein 12 isoform 1 [Homo sapiens];gi|530384249|ref|XP_005267292.1|//PREDICTED: A-kinase anchor protein 12 isoform X2 [Homo sapiens];gi|21493024|ref|NP_653080.1|//A-kinase anchor protein 12 isoform 2 [Homo sapiens] "]
[28512,2275,9.23,20.3,1.13707717442676,1.22110047433628e-17,"Up",5.11432e-19,"NKIRAS1","GO:0044424//intracellular part","GO:0032561//guanyl ribonucleotide binding;GO:0017111//nucleoside-triphosphatase activity","GO:0009207//purine ribonucleoside triphosphate catabolic process","K17197//NF-kappa-B inhibitor-interacting Ras-like protein","gi|982969637|ref|XP_015316384.1|//PREDICTED: NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1 [Bos taurus]"]
[2152,2393,4.03,8.84,1.13326653086346,6.87794511362284e-8,"Up",7.14222e-9,"F3","GO:0031224//intrinsic component of membrane;GO:0044421//extracellular region part;GO:0044424//intracellular part;GO:0009897//external side of plasma membrane","GO:0008289//lipid binding;GO:0019899//enzyme binding","GO:0034614//cellular response to reactive oxygen species;GO:0043066//negative regulation of apoptotic process;GO:0014909//smooth muscle cell migration;GO:0002237//response to molecule of bacterial origin;GO:0009628//response to abiotic stimulus;GO:0043627//response to estrogen;GO:0002526//acute inflammatory response;GO:0072376//protein activation cascade;GO:0045765//regulation of angiogenesis;GO:0050921//positive regulation of chemotaxis;GO:0055094//response to lipoprotein particle;GO:0007599//hemostasis;GO:0001935//endothelial cell proliferation","K03901//coagulation factor III (tissue factor)","gi|339504|gb|AAA61151.1|//tissue factor precursor [Homo sapiens];gi|296010912|ref|NP_001171567.1|//tissue factor isoform 2 precursor [Homo sapiens]"]
[7071,3120,4.97,10.9,1.133010378102,4.4902354875717e-12,"Up",2.9014e-13,"KLF10","GO:0043231//intracellular membrane-bounded organelle","GO:0046914//transition metal ion binding;GO:0001071//nucleic acid binding transcription factor activity;GO:0003676//nucleic acid binding","GO:0012502//induction of programmed cell death;GO:0007154//cell communication;GO:0007178//transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0006351//transcription, DNA-templated;GO:0048731//system development;GO:0001503//ossification;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0002763//positive regulation of myeloid leukocyte differentiation;GO:0019827//stem cell population maintenance;GO:0008283//cell proliferation;GO:0010033//response to organic substance","K09209//krueppel-like factor 10/11","gi|73760403|ref|NP_001027453.1|//Krueppel-like factor 10 isoform b [Homo sapiens];gi|966959379|ref|XP_015001215.1|//PREDICTED: Krueppel-like factor 10 isoform X1 [Macaca mulatta];gi|686728858|ref|XP_009242276.1|//PREDICTED: Krueppel-like factor 10 isoform X1 [Pongo abelii];gi|432172771|emb|CCO02797.1|//Kruppel-like factor 10 [Homo sapiens]"]
[64782,3210,17.33,37.92,1.12968730973809,6.62810915e-42,"Up",9.8267e-44,"AEN","GO:0031981//nuclear lumen","GO:0005488//binding;GO:0004518//nuclease activity","GO:0008630//intrinsic apoptotic signaling pathway in response to DNA damage;GO:0009314//response to radiation","K18340//apoptosis-enhancing nuclease [EC:3.1.-.-]","gi|694961178|ref|XP_510574.4|//PREDICTED: apoptosis-enhancing nuclease isoform X1 [Pan troglodytes];gi|675758485|ref|XP_003820459.2|//PREDICTED: apoptosis-enhancing nuclease isoform X1 [Pan paniscus]"]
[157567,2826,6.63,14.49,1.12797681944434,2.82375303055556e-14,"Up",1.507118e-15,"ANKRD46","GO:0031224//intrinsic component of membrane","NA","NA","K10380//ankyrin;K08803//death-associated protein kinase [EC:2.7.11.1]","gi|393290875|ref|NP_001257308.1|//ankyrin repeat domain-containing protein 46 isoform 2 [Homo sapiens];gi|927117156|ref|XP_013852025.1|//PREDICTED: ankyrin repeat domain-containing protein 46 isoform X1 [Sus scrofa]"]
[10221,3649,4.42,9.66,1.12797681944434,1.64795913485819e-11,"Up",1.112688e-12,"TRIB1","GO:0043231//intracellular membrane-bounded organelle","GO:0019887//protein kinase regulator activity;GO:0032559//adenyl ribonucleotide binding;GO:0016301//kinase activity;GO:0055103//ligase regulator activity;GO:0019901//protein kinase binding","GO:0000165//MAPK cascade;GO:0002832//negative regulation of response to biotic stimulus;GO:0014909//smooth muscle cell migration;GO:0002237//response to molecule of bacterial origin;GO:0033673//negative regulation of kinase activity;GO:0031331//positive regulation of cellular catabolic process;GO:0043392//negative regulation of DNA binding;GO:0006464//cellular protein modification process;GO:0009966//regulation of signal transduction;GO:0008285//negative regulation of cell proliferation","K08814//tribbles homolog 1/2","gi|13399328|ref|NP_079471.1|//tribbles homolog 1 isoform 1 [Homo sapiens]"]
[57613,4725,4.67,10.2,1.1270746971492,6.12910141424802e-16,"Up",2.86994e-17,"FAM234B","GO:0031224//intrinsic component of membrane","NA","NA","K17258//integrin alpha FG-GAP repeat containing protein 3","gi|62821776|ref|NP_065904.1|//uncharacterized protein KIAA1467 [Homo sapiens];gi|795333929|ref|XP_011740146.1|//PREDICTED: uncharacterized protein KIAA1467 homolog isoform X2 [Macaca nemestrina]"]
[80853,9178,0.93,2.03,1.12617710607714,6.33647211624286e-7,"Up",7.54286e-8,"KDM7A","GO:0031981//nuclear lumen","GO:0042393//histone binding;GO:0016701//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;GO:0016706//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0046914//transition metal ion binding;GO:0032452//histone demethylase activity","GO:0006355//regulation of transcription, DNA-templated;GO:0007420//brain development;GO:0070076//histone lysine demethylation","K11445//lysine-specific demethylase 7A [EC:1.14.11.-]","gi|51094786|gb|EAL24032.1|//KIAA1718 protein [Homo sapiens];gi|90093355|ref|NP_085150.1|//lysine-specific demethylase 7A [Homo sapiens]"]
[9842,4340,11.54,25.16,1.12448869823381,2.51624087116564e-34,"Up",5.0673e-36,"PLEKHM1","GO:0044424//intracellular part","GO:0043169//cation binding","GO:0007165//signal transduction","K19330//run domain Beclin-1 interacting and cysteine-rich containing protein","gi|767996644|ref|XP_011523827.1|//PREDICTED: pleckstrin homology domain-containing family M member 1 isoform X2 [Homo sapiens];gi|18676554|dbj|BAB84929.1|//FLJ00174 protein [Homo sapiens];gi|767996647|ref|XP_011523828.1|//PREDICTED: pleckstrin homology domain-containing family M member 1 isoform X3 [Homo sapiens];gi|767996654|ref|XP_011523830.1|//PREDICTED: pleckstrin homology domain-containing family M member 1 isoform X5 [Homo sapiens];gi|40538728|ref|NP_055613.1|//pleckstrin homology domain-containing family M member 1 [Homo sapiens]"]
[8728,6362,5.32,11.59,1.12338241550528,1.19140324974093e-29,"Up",2.84088e-31,"ADAM19","GO:0031224//intrinsic component of membrane","GO:0004175//endopeptidase activity;GO:0019904//protein domain specific binding;GO:0046914//transition metal ion binding","GO:0019538//protein metabolic process","K08608//disintegrin and metalloproteinase domain-containing protein 19 [EC:3.4.24.-]","gi|302393821|sp|Q9H013.3|ADA19_HUMAN//RecName: Full=Disintegrin and metalloproteinase domain-containing protein 19; Short=ADAM 19; AltName: Full=Meltrin-beta; AltName: Full=Metalloprotease and disintegrin dendritic antigen marker; Short=MADDAM; Flags: Precursor;gi|15451844|ref|NP_150377.1|//disintegrin and metalloproteinase domain-containing protein 19 preproprotein [Homo sapiens]"]
[19,9340,18.81,40.93,1.12165881791989,7.29653865e-136,"Up",2.16354e-138,"ABCA1","GO:0030139//endocytic vesicle;GO:0016021//integral component of membrane","GO:0032934//sterol binding;GO:0015075//ion transmembrane transporter activity;GO:0015248//sterol transporter activity;GO:0030226//apolipoprotein receptor activity;GO:0032559//adenyl ribonucleotide binding;GO:0017111//nucleoside-triphosphatase activity;GO:0051020//GTPase binding;GO:0019905//syntaxin binding","GO:0010878//cholesterol storage;GO:0032496//response to lipopolysaccharide;GO:0007166//cell surface receptor signaling pathway;GO:0015914//phospholipid transport;GO:0016125//sterol metabolic process;GO:0006909//phagocytosis;GO:0010874//regulation of cholesterol efflux;GO:0034377//plasma lipoprotein particle assembly;GO:0033363//secretory granule organization;GO:0006811//ion transport;GO:0032526//response to retinoic acid;GO:0006171//cAMP biosynthetic process;GO:0055092//sterol homeostasis;GO:0007266//Rho protein signal transduction;GO:0006464//cellular protein modification process;GO:0010742//macrophage derived foam cell differentiation;GO:0007033//vacuole organization;GO:0050701//interleukin-1 secretion","K05641//ATP-binding cassette, subfamily A (ABC1), member 1","gi|767956558|ref|XP_011516646.1|//PREDICTED: ATP-binding cassette sub-family A member 1 isoform X7 [Homo sapiens];gi|767956552|ref|XP_011516643.1|//PREDICTED: ATP-binding cassette sub-family A member 1 isoform X2 [Homo sapiens];gi|21536376|ref|NP_005493.2|//ATP-binding cassette sub-family A member 1 [Homo sapiens];gi|767956548|ref|XP_011516641.1|//PREDICTED: ATP-binding cassette sub-family A member 1 isoform X1 [Homo sapiens];gi|767956556|ref|XP_011516645.1|//PREDICTED: ATP-binding cassette sub-family A member 1 isoform X6 [Homo sapiens];gi|530390668|ref|XP_005251830.1|//PREDICTED: ATP-binding cassette sub-family A member 1 isoform X3 [Homo sapiens]"]
[23764,2444,11.17,24.3,1.12132712800983,6.54169616161616e-20,"Up",2.4004e-21,"MAFF","GO:0031981//nuclear lumen","GO:0003677//DNA binding;GO:0001071//nucleic acid binding transcription factor activity","GO:0050896//response to stimulus;GO:0022414//reproductive process;GO:0006351//transcription, DNA-templated;GO:0007599//hemostasis;GO:0043009//chordate embryonic development;GO:0045595//regulation of cell differentiation","K09037//transcription factor MAFF/G/K","gi|332231213|ref|XP_003264792.1|//PREDICTED: transcription factor MafF isoform X1 [Nomascus leucogenys];gi|820991931|ref|XP_003264791.2|//PREDICTED: transcription factor MafF isoform X2 [Nomascus leucogenys]"]
[440138,2595,1.87,4.06,1.11844145729754,0.000355925312491825,"Up",6.72362e-5,"ALG11","GO:0031224//intrinsic component of membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0031981//nuclear lumen;GO:0031090//organelle membrane;GO:0030684//preribosome","GO:0016757//transferase activity, transferring glycosyl groups;GO:0005488//binding","GO:0022403//cell cycle phase;GO:0042254//ribosome biogenesis;GO:0006487//protein N-linked glycosylation;GO:0048232//male gamete generation;GO:0048869//cellular developmental process","K14567//U3 small nucleolar RNA-associated protein 14;K03844//alpha-1,2-mannosyltransferase [EC:2.4.1.131]","gi|304434672|ref|NP_001004127.2|//GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase [Homo sapiens];gi|51871374|ref|NP_067677.4|//U3 small nucleolar RNA-associated protein 14 homolog C [Homo sapiens]"]
[51430,5553,5.67,12.27,1.11371460872068,8.53399958528428e-20,"Up",3.15254e-21,"SUCO","GO:0031224//intrinsic component of membrane;GO:0005789//endoplasmic reticulum membrane","NA","GO:0032501//multicellular organismal process","NA","gi|119611335|gb|EAW90929.1|//chromosome 1 open reading frame 9, isoform CRA_a [Homo sapiens];gi|578801077|ref|XP_006711438.1|//PREDICTED: SUN domain-containing ossification factor isoform X2 [Homo sapiens];gi|119611339|gb|EAW90933.1|//chromosome 1 open reading frame 9, isoform CRA_e [Homo sapiens];gi|544346209|ref|NP_057311.3|//SUN domain-containing ossification factor isoform 2 [Homo sapiens];gi|544346129|ref|NP_001269679.1|//SUN domain-containing ossification factor isoform 3 precursor [Homo sapiens] "]
[10105,1872,41.52,89.78,1.11258765255766,4.9960496342246e-55,"Up",5.77132e-57,"PPIF","GO:0044429//mitochondrial part;GO:0019866//organelle inner membrane","GO:0008144//drug binding;GO:0016859//cis-trans isomerase activity","GO:0044267//cellular protein metabolic process;GO:0007006//mitochondrial membrane organization;GO:0006915//apoptotic process","K09565//peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8]","gi|530392757|ref|XP_005269436.1|//PREDICTED: peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [Homo sapiens];gi|5031987|ref|NP_005720.1|//peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor [Homo sapiens]"]
[604,4241,2.23,4.82,1.11198943630966,3.15973203355973e-5,"Up",4.8856e-6,"BCL6","GO:0031981//nuclear lumen;GO:0044427//chromosomal part","GO:0003677//DNA binding;GO:0046914//transition metal ion binding;GO:0001071//nucleic acid binding transcription factor activity","GO:0033554//cellular response to stress;GO:0001783//B cell apoptotic process;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0002682//regulation of immune system process;GO:0002467//germinal center formation;GO:0006606//protein import into nucleus;GO:0016049//cell growth","K15618//B-cell lymphoma 6 protein","gi|795311563|ref|XP_011816989.1|//PREDICTED: B-cell lymphoma 6 protein isoform X1 [Colobus angolensis palliatus];gi|197927147|ref|NP_001128210.1|//B-cell lymphoma 6 protein isoform 2 [Homo sapiens]"]
[5997,1375,3.51,7.56,1.10691520391651,0.000502727673345936,"Up",9.85704e-5,"RGS2","GO:0016020//membrane;GO:0044424//intracellular part","GO:0005515//protein binding;GO:0060089//molecular transducer activity;GO:0008047//enzyme activator activity","GO:0007186//G-protein coupled receptor signaling pathway;GO:0045444//fat cell differentiation;GO:0048232//male gamete generation","K18154//regulator of G-protein signaling 2","gi|635131864|ref|XP_007987318.1|//PREDICTED: regulator of G-protein signaling 2 [Chlorocebus sabaeus]"]
[7048,4671,3.9,8.39,1.10519668669021,1.92620178283262e-13,"Up",1.108982e-14,"TGFBR2","GO:0031224//intrinsic component of membrane;GO:0009986//cell surface;GO:0044459//plasma membrane part;GO:0043235//receptor complex","GO:0043169//cation binding;GO:0032559//adenyl ribonucleotide binding;GO:0030247//polysaccharide binding;GO:0005024//transforming growth factor beta-activated receptor activity;GO:0019838//growth factor binding;GO:0005160//transforming growth factor beta receptor binding","GO:0001773//myeloid dendritic cell activation;GO:0033993//response to lipid;GO:0001525//angiogenesis;GO:0007178//transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0046638//positive regulation of alpha-beta T cell differentiation;GO:0007417//central nervous system development;GO:0002513//tolerance induction to self antigen;GO:0002514//B cell tolerance induction;GO:0048704//embryonic skeletal system morphogenesis;GO:0045860//positive regulation of protein kinase activity;GO:0002517//T cell tolerance induction;GO:0008284//positive regulation of cell proliferation","K04388//TGF-beta receptor type-2 [EC:2.7.11.30]","gi|767924117|ref|XP_011532345.1|//PREDICTED: TGF-beta receptor type-2 isoform X1 [Homo sapiens];gi|67782324|ref|NP_003233.4|//TGF-beta receptor type-2 isoform B precursor [Homo sapiens];gi|67782326|ref|NP_001020018.1|//TGF-beta receptor type-2 isoform A precursor [Homo sapiens]"]
[57535,6829,0.73,1.57,1.10479619001161,0.000183189703333333,"Up",3.25912e-5,"KIAA1324","NA","NA","NA","K17495//CUB and sushi domain-containing protein;K12581//CCR4-NOT transcription complex subunit 7/8;K17985//activating molecule in BECN1-regulated autophagy protein 1;K04659//thrombospondin 2/3/4/5","gi|38569482|ref|NP_065826.2|//UPF0577 protein KIAA1324 isoform 1 [Homo sapiens];gi|767905245|ref|XP_011540129.1|//PREDICTED: UPF0577 protein KIAA1324 isoform X3 [Homo sapiens];gi|547235656|ref|NP_001271282.1|//UPF0577 protein KIAA1324 isoform 5 [Homo sapiens];gi|388490233|ref|NP_001253977.1|//UPF0577 protein KIAA1324 isoform 2 [Homo sapiens];gi|767905241|ref|XP_011540127.1|//PREDICTED: UPF0577 protein KIAA1324 isoform X1 [Homo sapiens];gi|194386280|dbj|BAG59704.1|//unnamed protein product [Homo sapiens];gi|767905243|ref|XP_011540128.1|//PREDICTED: UPF0577 protein KIAA1324 isoform X2 [Homo sapiens];gi|147647000|sp|Q6UXG2.2|K1324_HUMAN//RecName: Full=UPF0577 protein KIAA1324; AltName: Full=Estrogen-induced gene 121 protein; Flags: Precursor"]
[57561,4178,6.92,14.88,1.10453058347131,2.14681447058824e-20,"Up",7.6653e-22,"ARRDC3","GO:0044424//intracellular part","GO:0005488//binding","GO:0023052//signaling","K20910//thioredoxin-interacting protein","gi|28972730|dbj|BAC65781.1|//mKIAA1376 protein [Mus musculus]"]
[27042,4041,7.36,15.77,1.0994049887335,7.63594629213483e-12,"Up",5.0378e-13,"DIEXF","GO:0043231//intracellular membrane-bounded organelle","NA","GO:0032501//multicellular organismal process","K14774//U3 small nucleolar RNA-associated protein 25","gi|51491238|emb|CAH18684.1|//hypothetical protein [Homo sapiens];gi|578800821|ref|XP_006711338.1|//PREDICTED: digestive organ expansion factor homolog isoform X1 [Homo sapiens];gi|75677335|ref|NP_055203.4|//digestive organ expansion factor homolog [Homo sapiens]"]
[85414,3252,2.61,5.57,1.09362752077015,5.76302545936183e-8,"Up",5.91326e-9,"SLC45A3","GO:0031224//intrinsic component of membrane","NA","GO:0006810//transport","K15379//solute carrier family 45, member 3","gi|14916437|ref|NP_149093.1|//solute carrier family 45 member 3 [Homo sapiens];gi|530365529|ref|XP_005245617.1|//PREDICTED: solute carrier family 45 member 3 isoform X2 [Homo sapiens]"]
[2004,4195,5.18,11.03,1.09040878790483,4.85344583970407e-15,"Up",2.43152e-16,"ELK3","GO:0031981//nuclear lumen","GO:0043565//sequence-specific DNA binding;GO:0003712//transcription cofactor activity","GO:0010467//gene expression;GO:0023052//signaling;GO:0009987//cellular process","K09430//ETS domain-containing protein Elk-3 (SRF accessory protein 2)","gi|821001678|ref|XP_012355651.1|//PREDICTED: ETS domain-containing protein Elk-3 isoform X2 [Nomascus leucogenys];gi|44955921|ref|NP_005221.2|//ETS domain-containing protein Elk-3 isoform 1 [Homo sapiens]"]
[868,5205,3.65,7.73,1.08257195015747,1.13144865075226e-12,"Up",6.96846e-14,"CBLB","GO:0031981//nuclear lumen","GO:0046872//metal ion binding;GO:0060089//molecular transducer activity;GO:0046914//transition metal ion binding;GO:0003824//catalytic activity","GO:0042110//T cell activation;GO:0002683//negative regulation of immune system process;GO:0007166//cell surface receptor signaling pathway;GO:0002684//positive regulation of immune system process;GO:0009896//positive regulation of catabolic process;GO:0050856//regulation of T cell receptor signaling pathway;GO:0042130//negative regulation of T cell proliferation;GO:0048523//negative regulation of cellular process;GO:0002666//positive regulation of T cell tolerance induction;GO:0006606//protein import into nucleus","K04707//E3 ubiquitin-protein ligase CBL [EC:2.3.2.27]","gi|767927876|ref|XP_011511561.1|//PREDICTED: E3 ubiquitin-protein ligase CBL-B isoform X3 [Homo sapiens];gi|817262268|ref|XP_012332083.1|//PREDICTED: E3 ubiquitin-protein ligase CBL-B isoform X2 [Aotus nancymaae];gi|795412827|ref|XP_011945409.1|//PREDICTED: E3 ubiquitin-protein ligase CBL-B isoform X1 [Cercocebus atys];gi|194380076|dbj|BAG63805.1|//unnamed protein product [Homo sapiens];gi|675781136|ref|XP_008976993.1|//PREDICTED: E3 ubiquitin-protein ligase CBL-B isoform X1 [Pan paniscus];gi|862407|gb|AAB09291.1|//cbl-b [Homo sapiens];gi|675781147|ref|XP_008976998.1|//PREDICTED: E3 ubiquitin-protein ligase CBL-B isoform X4 [Pan paniscus];gi|221045940|dbj|BAH14647.1|//unnamed protein product [Homo sapiens];gi|675781145|ref|XP_003825100.2|//PREDICTED: E3 ubiquitin-protein ligase CBL-B isoform X3 [Pan paniscus];gi|694903227|ref|XP_009444365.1|//PREDICTED: E3 ubiquitin-protein ligase CBL-B isoform X3 [Pan troglodytes]"]
[7643,3767,3.75,7.93,1.08043027032074,5.13823042622951e-10,"Up",4.06602e-11,"ZNF90","GO:0043231//intracellular membrane-bounded organelle","GO:0046914//transition metal ion binding;GO:0001071//nucleic acid binding transcription factor activity","GO:0006351//transcription, DNA-templated","K09228//KRAB domain-containing zinc finger protein","gi|209862791|ref|NP_009069.1|//zinc finger protein 90 [Homo sapiens]"]
[4783,2096,2.82,5.96,1.07961716806337,0.000175556010596026,"Up",3.11138e-5,"NFIL3","GO:0043231//intracellular membrane-bounded organelle","GO:0003677//DNA binding;GO:0005515//protein binding;GO:0003712//transcription cofactor activity;GO:0001071//nucleic acid binding transcription factor activity","GO:0002376//immune system process;GO:0006351//transcription, DNA-templated;GO:0048511//rhythmic process","K09059//nuclear factor, interleukin 3 regulated","gi|52630429|ref|NP_005375.2|//nuclear factor interleukin-3-regulated protein [Homo sapiens]"]
[55802,5983,3.25,6.86,1.077768858257,2.82725565811241e-13,"Up",1.646962e-14,"DCP1A","GO:0043231//intracellular membrane-bounded organelle;GO:0030529//intracellular ribonucleoprotein complex;GO:0044444//cytoplasmic part","GO:0003824//catalytic activity;GO:0005488//binding","GO:0000291//nuclear-transcribed mRNA catabolic process, exonucleolytic","K12610//mRNA-decapping enzyme 1A [EC:3.-.-.-]","gi|291327466|ref|NP_060873.4|//mRNA-decapping enzyme 1A isoform a [Homo sapiens];gi|589269220|ref|NP_001277133.1|//mRNA-decapping enzyme 1A isoform b [Homo sapiens] "]
[6574,3418,61.57,129.93,1.07743510457364,2.38505725787234e-137,"Up",6.92474e-140,"SLC20A1","GO:0016021//integral component of membrane","GO:0004871//signal transducer activity;GO:0005436//sodium:phosphate symporter activity","GO:0006817//phosphate ion transport;GO:0007249//I-kappaB kinase/NF-kappaB signaling;GO:0006793//phosphorus metabolic process;GO:0030001//metal ion transport","K14640//solute carrier family 20 (sodium-dependent phosphate transporter)","gi|767919391|ref|XP_011509988.1|//PREDICTED: sodium-dependent phosphate transporter 1 isoform X1 [Homo sapiens];gi|31543630|ref|NP_005406.3|//sodium-dependent phosphate transporter 1 [Homo sapiens]"]
[1390,1941,12.94,27.3,1.07706333381471,1.2957632217119e-24,"Up",3.83414e-26,"CREM","GO:0043231//intracellular membrane-bounded organelle;GO:0043234//protein complex","GO:0003677//DNA binding;GO:0003713//transcription coactivator activity;GO:0005515//protein binding;GO:0001071//nucleic acid binding transcription factor activity","GO:0019935//cyclic-nucleotide-mediated signaling;GO:0007623//circadian rhythm;GO:0048232//male gamete generation;GO:0006351//transcription, DNA-templated;GO:0048869//cellular developmental process;GO:0030522//intracellular receptor signaling pathway;GO:0006664//glycolipid metabolic process;GO:0032787//monocarboxylic acid metabolic process;GO:0023052//signaling;GO:0019318//hexose metabolic process","K09052//cAMP response element modulator","gi|34335222|ref|NP_898829.1|//cAMP-responsive element modulator isoform 21 [Homo sapiens] ;gi|62088646|dbj|BAD92770.1|//cAMP responsive element modulator isoform u variant [Homo sapiens];gi|389616127|ref|NP_001254493.1|//cAMP-responsive element modulator isoform 25 [Homo sapiens];gi|578818264|ref|XP_006717445.1|//PREDICTED: cAMP-responsive element modulator isoform X18 [Homo sapiens];gi|8248902|gb|AAC60617.2|//cyclic AMP-responsive element modulator beta isoform [Homo sapiens];gi|34335228|ref|NP_898883.1|//cAMP-responsive element modulator isoform 22 [Homo sapiens];gi|884911078|ref|XP_005003284.2|//PREDICTED: cAMP-responsive element modulator isoform X10 [Cavia porcellus];gi|578818274|ref|XP_006717450.1|//PREDICTED: cAMP-responsive element modulator isoform X12 [Homo sapiens];gi|675667484|ref|XP_008998429.1|//PREDICTED: cAMP-responsive element modulator isoform X20 [Callithrix jacchus];gi|686732891|ref|XP_009243542.1|//PREDICTED: cAMP-responsive element modulator isoform X6 [Pongo abelii];gi|767959687|ref|XP_011517626.1|//PREDICTED: cAMP-responsive element modulator isoform X11 [Homo sapiens];gi|389616137|ref|NP_001254498.1|//cAMP-responsive element modulator isoform 30 [Homo sapiens];gi|472391015|ref|XP_004414809.1|//PREDICTED: cAMP-responsive element modulator isoform X22 [Odobenus rosmarus divergens];gi|34335226|ref|NP_898831.1|//cAMP-responsive element modulator isoform 19 [Homo sapiens];gi|675667488|ref|XP_008998431.1|//PREDICTED: cAMP-responsive element modulator isoform X22 [Callithrix jacchus];gi|675667482|ref|XP_008998428.1|//PREDICTED: cAMP-responsive element modulator isoform X19 [Callithrix jacchus];gi|389616135|ref|NP_001254497.1|//cAMP-responsive element modulator isoform 29 [Homo sapiens];gi|884911072|ref|XP_003468673.3|//PREDICTED: cAMP-responsive element modulator isoform X7 [Cavia porcellus];gi|767959710|ref|XP_011517635.1|//PREDICTED: cAMP-responsive element modulator isoform X20 [Homo sapiens];gi|1256546|gb|AAA96340.1|//CREMdeltaC-G [Rattus norvegicus];gi|884911074|ref|XP_005003283.2|//PREDICTED: cAMP-responsive element modulator isoform X8 [Cavia porcellus];gi|767959698|ref|XP_011517630.1|//PREDICTED: cAMP-responsive element modulator isoform X14 [Homo sapiens];gi|34335216|ref|NP_877573.1|//cAMP-responsive element modulator isoform 16 [Homo sapiens] ;gi|675667486|ref|XP_008998430.1|//PREDICTED: cAMP-responsive element modulator isoform X21 [Callithrix jacchus];gi|724946921|ref|XP_010387697.1|//PREDICTED: cAMP-responsive element modulator isoform X8 [Rhinopithecus roxellana];gi|767959685|ref|XP_011517625.1|//PREDICTED: cAMP-responsive element modulator isoform X10 [Homo sapiens];gi|389616139|ref|NP_001254499.1|//cAMP-responsive element modulator isoform 31 [Homo sapiens];gi|34335224|ref|NP_898830.1|//cAMP-responsive element modulator isoform 20 [Homo sapiens] ;gi|389616131|ref|NP_001254495.1|//cAMP-responsive element modulator isoform 27 [Homo sapiens];gi|635052697|ref|XP_008000993.1|//PREDICTED: cAMP-responsive element modulator isoform X9 [Chlorocebus sabaeus];gi|635052709|ref|XP_008000999.1|//PREDICTED: cAMP-responsive element modulator isoform X15 [Chlorocebus sabaeus];gi|119606322|gb|EAW85916.1|//cAMP responsive element modulator, isoform CRA_a [Homo sapiens];gi|389616129|ref|NP_001254494.1|//cAMP-responsive element modulator isoform 26 [Homo sapiens];gi|34335214|ref|NP_877572.1|//cAMP-responsive element modulator isoform 15 [Homo sapiens];gi|34335196|ref|NP_874390.1|//cAMP-responsive element modulator isoform 8 [Homo sapiens] ;gi|982267722|ref|XP_015311257.1|//PREDICTED: cAMP-responsive element modulator isoform X8 [Macaca fascicularis];gi|767959694|ref|XP_011517628.1|//PREDICTED: cAMP-responsive element modulator isoform X13 [Homo sapiens];gi|34335186|ref|NP_853549.1|//cAMP-responsive element modulator isoform 1 [Homo sapiens] ;gi|34335202|ref|NP_874393.1|//cAMP-responsive element modulator isoform 11 [Homo sapiens] "]
[4189,2538,3.95,8.33,1.07646384230108,3.69959265306122e-7,"Up",4.2554e-8,"DNAJB9","GO:0031981//nuclear lumen","GO:0005515//protein binding","GO:0043161//proteasome-mediated ubiquitin-dependent protein catabolic process","K09515//DnaJ homolog subfamily B member 9","gi|426357548|ref|XP_004046099.1|//PREDICTED: dnaJ homolog subfamily B member 9 isoform 2 [Gorilla gorilla gorilla]"]
[159371,2513,5.52,11.64,1.07635088613012,2.31742670048781e-10,"Up",1.760832e-11,"SLC35G1","GO:0031224//intrinsic component of membrane","NA","NA","NA","gi|197927233|ref|NP_001128130.1|//solute carrier family 35 member G1 isoform 1 [Homo sapiens];gi|767961828|ref|XP_011537675.1|//PREDICTED: solute carrier family 35 member G1 isoform X3 [Homo sapiens];gi|767961824|ref|XP_011537673.1|//PREDICTED: solute carrier family 35 member G1 isoform X1 [Homo sapiens];gi|23397492|ref|NP_694958.1|//solute carrier family 35 member G1 isoform 2 [Homo sapiens]"]
[5874,5760,1.5,3.16,1.07496205768122,0.000346872984534731,"Up",6.53976e-5,"RAB27B","GO:0030667//secretory granule membrane","GO:0032561//guanyl ribonucleotide binding;GO:0017111//nucleoside-triphosphatase activity","GO:0035556//intracellular signal transduction;GO:0009207//purine ribonucleoside triphosphate catabolic process;GO:0006887//exocytosis","K07886//Ras-related protein Rab-27B","gi|578832631|ref|XP_006722581.1|//PREDICTED: ras-related protein Rab-27B isoform X3 [Homo sapiens];gi|635098554|ref|XP_008012218.1|//PREDICTED: ras-related protein Rab-27B isoform X1 [Chlorocebus sabaeus]"]
[3090,3174,6.93,14.56,1.07108309806148,1.37119481950059e-14,"Up",7.12364e-16,"HIC1","GO:0005622//intracellular","GO:0005488//binding;GO:0001071//nucleic acid binding transcription factor activity","GO:0006351//transcription, DNA-templated","K09228//KRAB domain-containing zinc finger protein","gi|982302464|ref|XP_005582531.2|//PREDICTED: hypermethylated in cancer 1 protein isoform X1 [Macaca fascicularis];gi|148237270|ref|NP_001091672.1|//hypermethylated in cancer 1 protein isoform 2 [Homo sapiens]"]
[7078,5496,7.73,16.23,1.07012268062312,1.08759632907801e-27,"Up",2.84194e-29,"TIMP3","GO:0044424//intracellular part;GO:0005578//proteinaceous extracellular matrix","GO:0043169//cation binding;GO:0004866//endopeptidase inhibitor activity","GO:0007399//nervous system development;GO:0048545//response to steroid hormone;GO:0009605//response to external stimulus;GO:0031330//negative regulation of cellular catabolic process;GO:0001101//response to acid chemical;GO:0050953//sensory perception of light stimulus;GO:0009888//tissue development","K16866//metalloproteinase inhibitor 3","gi|4507513|ref|NP_000353.1|//metalloproteinase inhibitor 3 precursor [Homo sapiens]"]
[23119,6962,3.01,6.31,1.06787651822285,2.52118583189756e-14,"Up",1.337842e-15,"HIC2","GO:0031981//nuclear lumen;GO:0005924//cell-substrate adherens junction","GO:0005515//protein binding;GO:0046914//transition metal ion binding;GO:0003676//nucleic acid binding","GO:0006355//regulation of transcription, DNA-templated","K09228//KRAB domain-containing zinc finger protein","gi|139394599|ref|NP_055909.2|//hypermethylated in cancer 2 protein [Homo sapiens]"]
[605,3734,5.86,12.28,1.06733799094793,2.72839704837209e-14,"Up",1.449482e-15,"BCL7A","NA","NA","NA","NA","gi|10337613|ref|NP_066273.1|//B-cell CLL/lymphoma 7 protein family member A isoform a [Homo sapiens];gi|148687692|gb|EDL19639.1|//B-cell CLL/lymphoma 7A, isoform CRA_a, partial [Mus musculus]"]
[27,8878,12.17,25.43,1.06320229397638,8.64158849162011e-57,"Up",9.5555e-59,"ABL2","GO:0043232//intracellular non-membrane-bounded organelle;GO:0044444//cytoplasmic part","GO:0004713//protein tyrosine kinase activity;GO:0032559//adenyl ribonucleotide binding;GO:0046914//transition metal ion binding","GO:0023052//signaling;GO:0006468//protein phosphorylation;GO:0006935//chemotaxis;GO:0043085//positive regulation of catalytic activity","K08887//abelson tyrosine-protein kinase 2 [EC:2.7.10.2]","gi|269847786|ref|NP_001161710.1|//Abelson tyrosine-protein kinase 2 isoform h [Homo sapiens];gi|119611447|gb|EAW91041.1|//v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene), isoform CRA_b [Homo sapiens];gi|209862778|ref|NP_001129473.1|//Abelson tyrosine-protein kinase 2 isoform e [Homo sapiens] ;gi|269847776|ref|NP_001161708.1|//Abelson tyrosine-protein kinase 2 isoform f [Homo sapiens];gi|966923293|ref|XP_014978317.1|//PREDICTED: Abelson tyrosine-protein kinase 2 isoform X6 [Macaca mulatta];gi|31874804|emb|CAD98092.1|//hypothetical protein [Homo sapiens];gi|269847768|ref|NP_005149.4|//Abelson tyrosine-protein kinase 2 isoform c [Homo sapiens];gi|269847781|ref|NP_001161709.1|//Abelson tyrosine-protein kinase 2 isoform g [Homo sapiens];gi|6382062|ref|NP_009298.1|//Abelson tyrosine-protein kinase 2 isoform b [Homo sapiens]"]
[10019,5563,8.5,17.69,1.05739930166539,1.15689701745636e-28,"Up",2.8658e-30,"SH2B3","GO:0044444//cytoplasmic part","GO:0060089//molecular transducer activity","GO:0007165//signal transduction;GO:0007599//hemostasis;GO:0030097//hemopoiesis;GO:0048869//cellular developmental process","K12459//SH2B adaptor protein 1/3","gi|530401163|ref|XP_005253875.1|//PREDICTED: SH2B adapter protein 3 isoform X2 [Homo sapiens];gi|4885455|ref|NP_005466.1|//SH2B adapter protein 3 isoform 1 [Homo sapiens];gi|767972740|ref|XP_011536023.1|//PREDICTED: SH2B adapter protein 3 isoform X4 [Homo sapiens];gi|767972734|ref|XP_011536021.1|//PREDICTED: SH2B adapter protein 3 isoform X1 [Homo sapiens];gi|611435019|ref|NP_001278353.1|//SH2B adapter protein 3 isoform 2 [Homo sapiens];gi|530401165|ref|XP_005253876.1|//PREDICTED: SH2B adapter protein 3 isoform X3 [Homo sapiens]"]
[342184,12265,2.68,5.57,1.05544432688226,2.65277849752883e-19,"Up",9.9471e-21,"FMN1","GO:0043231//intracellular membrane-bounded organelle;GO:0005856//cytoskeleton;GO:0070161//anchoring junction","GO:0008092//cytoskeletal protein binding","GO:0007010//cytoskeleton organization","K10367//formin 1","gi|767983987|ref|XP_011519810.1|//PREDICTED: formin-1 isoform X5 [Homo sapiens];gi|767983983|ref|XP_011519808.1|//PREDICTED: formin-1 isoform X3 [Homo sapiens];gi|767983995|ref|XP_011519814.1|//PREDICTED: formin-1 isoform X9 [Homo sapiens];gi|157168329|ref|NP_001096654.1|//formin-1 isoform b [Homo sapiens] ;gi|472235321|ref|NP_001264243.1|//formin-1 isoform c [Homo sapiens]"]
[8613,3324,1.93,4.01,1.05500138918684,0.000110858356608696,"Up",1.890098e-5,"PLPP3","GO:0031224//intrinsic component of membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0031090//organelle membrane;GO:0070161//anchoring junction","GO:0005488//binding;GO:0016791//phosphatase activity","GO:0007369//gastrulation;GO:0016337//single organismal cell-cell adhesion;GO:0006643//membrane lipid metabolic process;GO:0001932//regulation of protein phosphorylation;GO:0060070//canonical Wnt signaling pathway;GO:0001944//vasculature development;GO:0019637//organophosphate metabolic process;GO:0031647//regulation of protein stability;GO:0007276//gamete generation;GO:0043388//positive regulation of DNA binding","K01080//phosphatidate phosphatase [EC:3.1.3.4]","gi|29171740|ref|NP_003704.3|//phospholipid phosphatase 3 [Homo sapiens]"]
[3589,2376,25.01,51.96,1.05489637326691,1.02505520547945e-36,"Up",1.849e-38,"IL11","GO:0005576//extracellular region","GO:0005126//cytokine receptor binding","GO:0030098//lymphocyte differentiation;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0008283//cell proliferation;GO:0046883//regulation of hormone secretion;GO:0030099//myeloid cell differentiation;GO:0001934//positive regulation of protein phosphorylation","K05417//interleukin 11","gi|821139439|ref|XP_004480339.2|//PREDICTED: interleukin-11 [Dasypus novemcinctus];gi|675969802|pdb|4MHL|A//Chain A, The Crystal Structure Of Human Interleukin-11"]
[960,3754,29.17,60.6,1.05483240746214,1.49801605524862e-56,"Up",1.67495e-58,"CD44","GO:0016020//membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0016021//integral component of membrane","GO:0005515//protein binding;GO:0004872//receptor activity;GO:0005539//glycosaminoglycan binding","GO:0007155//cell adhesion;GO:0009968//negative regulation of signal transduction;GO:0043410//positive regulation of MAPK cascade;GO:0001934//positive regulation of protein phosphorylation;GO:0031589//cell-substrate adhesion;GO:0019221//cytokine-mediated signaling pathway;GO:0006915//apoptotic process","K06256//CD44 antigen","gi|321400138|ref|NP_001189484.1|//CD44 antigen isoform 6 precursor [Homo sapiens];gi|530396006|ref|XP_005253289.1|//PREDICTED: CD44 antigen isoform X2 [Homo sapiens];gi|767966868|ref|XP_011518791.1|//PREDICTED: CD44 antigen isoform X17 [Homo sapiens];gi|119588551|gb|EAW68145.1|//CD44 antigen (Indian blood group), isoform CRA_b [Homo sapiens];gi|578820976|ref|XP_006718453.1|//PREDICTED: CD44 antigen isoform X18 [Homo sapiens];gi|795608321|ref|XP_011917637.1|//PREDICTED: CD44 antigen isoform X19 [Cercocebus atys];gi|119588561|gb|EAW68155.1|//CD44 antigen (Indian blood group), isoform CRA_j [Homo sapiens];gi|767966862|ref|XP_011518788.1|//PREDICTED: CD44 antigen isoform X13 [Homo sapiens];gi|530396012|ref|XP_005253292.1|//PREDICTED: CD44 antigen isoform X6 [Homo sapiens];gi|48255937|ref|NP_001001389.1|//CD44 antigen isoform 2 precursor [Homo sapiens];gi|767966854|ref|XP_011518784.1|//PREDICTED: CD44 antigen isoform X7 [Homo sapiens];gi|694944091|ref|XP_009458500.1|//PREDICTED: CD44 antigen isoform X13 [Pan troglodytes];gi|321400142|ref|NP_001189486.1|//CD44 antigen isoform 8 precursor [Homo sapiens];gi|530396004|ref|XP_005253288.1|//PREDICTED: CD44 antigen isoform X1 [Homo sapiens];gi|48255935|ref|NP_000601.3|//CD44 antigen isoform 1 precursor [Homo sapiens];gi|530396020|ref|XP_005253296.1|//PREDICTED: CD44 antigen isoform X12 [Homo sapiens];gi|767966856|ref|XP_011518785.1|//PREDICTED: CD44 antigen isoform X8 [Homo sapiens];gi|578820966|ref|XP_006718451.1|//PREDICTED: CD44 antigen isoform X3 [Homo sapiens];gi|530396008|ref|XP_005253290.1|//PREDICTED: CD44 antigen isoform X4 [Homo sapiens];gi|767966860|ref|XP_011518787.1|//PREDICTED: CD44 antigen isoform X10 [Homo sapiens];gi|48255939|ref|NP_001001390.1|//CD44 antigen isoform 3 precursor [Homo sapiens];gi|48255941|ref|NP_001001391.1|//CD44 antigen isoform 4 precursor [Homo sapiens];gi|767966864|ref|XP_011518789.1|//PREDICTED: CD44 antigen isoform X15 [Homo sapiens];gi|530396010|ref|XP_005253291.1|//PREDICTED: CD44 antigen isoform X5 [Homo sapiens];gi|767966858|ref|XP_011518786.1|//PREDICTED: CD44 antigen isoform X9 [Homo sapiens];gi|530396018|ref|XP_005253295.1|//PREDICTED: CD44 antigen isoform X11 [Homo sapiens];gi|321400140|ref|NP_001189485.1|//CD44 antigen isoform 7 precursor [Homo sapiens];gi|48255943|ref|NP_001001392.1|//CD44 antigen isoform 5 precursor [Homo sapiens]"]
[51524,1162,15.09,31.3,1.0525698512933,1.23017827438867e-5,"Up",1.771402e-6,"TMEM138","GO:0016020//membrane;GO:0031224//intrinsic component of membrane","NA","NA","K12581//CCR4-NOT transcription complex subunit 7/8;K17985//activating molecule in BECN1-regulated autophagy protein 1","gi|675701571|ref|XP_009006538.1|//PREDICTED: transmembrane protein 138 isoform X4 [Callithrix jacchus];gi|795168221|ref|XP_011798131.1|//PREDICTED: transmembrane protein 138 isoform X3 [Colobus angolensis palliatus];gi|7705505|ref|NP_057548.1|//transmembrane protein 138 [Homo sapiens];gi|488557862|ref|XP_004469387.1|//PREDICTED: transmembrane protein 138 isoform X1 [Dasypus novemcinctus];gi|528769982|gb|EPY89641.1|//hypothetical protein CB1_000089007 [Camelus ferus];gi|635013056|ref|XP_007994488.1|//PREDICTED: transmembrane protein 138 isoform X1 [Chlorocebus sabaeus]"]
[55966,3723,4.01,8.3,1.04950909977937,1.1902199675919e-9,"Up",9.80086e-11,"AJAP1","GO:0030054//cell junction","NA","NA","NA","gi|9055278|ref|NP_061324.1|//adherens junction-associated protein 1 precursor [Homo sapiens]"]
[8846,2585,8.07,16.66,1.04574782208777,4.05572832601881e-13,"Up",2.39766e-14,"ALKBH1","GO:0000790//nuclear chromatin","GO:0005506//iron ion binding;GO:0016701//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;GO:0016706//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0016835//carbon-oxygen lyase activity","GO:0016070//RNA metabolic process;GO:0016477//cell migration;GO:0048513//animal organ development;GO:0006281//DNA repair;GO:0035510//DNA dealkylation;GO:0030030//cell projection organization;GO:0043009//chordate embryonic development;GO:0055114//oxidation-reduction process;GO:0048869//cellular developmental process;GO:0043523//regulation of neuron apoptotic process;GO:0010467//gene expression;GO:0040007//growth","K10765//alkylated DNA repair protein alkB homolog 1 [EC:1.14.11.- 4.2.99.18]","gi|87298840|ref|NP_006011.2|//DNA oxidative demethylase ALKBH1 [Homo sapiens]"]
[84879,2178,3.75,7.71,1.03984026453179,1.65354597223391e-5,"Up",2.42802e-6,"MFSD2A","GO:0043231//intracellular membrane-bounded organelle;GO:0031224//intrinsic component of membrane;GO:0031090//organelle membrane","NA","GO:0006810//transport","K08824//cyclin-dependent kinase-like [EC:2.7.11.22]","gi|211063479|ref|NP_001129965.1|//sodium-dependent lysophosphatidylcholine symporter 1 isoform 1 [Homo sapiens];gi|767906461|ref|XP_011540614.1|//PREDICTED: sodium-dependent lysophosphatidylcholine symporter 1 isoform X2 [Homo sapiens];gi|42713696|ref|NP_116182.2|//sodium-dependent lysophosphatidylcholine symporter 1 isoform 2 [Homo sapiens];gi|568214679|ref|NP_001274738.1|//sodium-dependent lysophosphatidylcholine symporter 1 isoform 4 [Homo sapiens];gi|530363498|ref|XP_005271342.1|//PREDICTED: sodium-dependent lysophosphatidylcholine symporter 1 isoform X1 [Homo sapiens]"]
[3383,3249,14.01,28.79,1.03911083313262,1.80984114660422e-27,"Up",4.77392e-29,"ICAM1","GO:0044421//extracellular region part;GO:0009986//cell surface;GO:0044459//plasma membrane part;GO:0016021//integral component of membrane","GO:0004872//receptor activity;GO:0005102//receptor binding","GO:0001101//response to acid chemical;GO:0019229//regulation of vasoconstriction;GO:0043271//negative regulation of ion transport;GO:0032496//response to lipopolysaccharide;GO:0002456//T cell mediated immunity;GO:0043279//response to alkaloid;GO:0051091//positive regulation of sequence-specific DNA binding transcription factor activity;GO:0070555//response to interleukin-1;GO:0002286//T cell activation involved in immune response;GO:0022406//membrane docking;GO:0010038//response to metal ion;GO:0022602//ovulation cycle process;GO:0016337//single organismal cell-cell adhesion;GO:0001909//leukocyte mediated cytotoxicity;GO:0001666//response to hypoxia;GO:0007568//aging;GO:0001678//cellular glucose homeostasis;GO:0009314//response to radiation;GO:0051702//interaction with symbiont;GO:0034612//response to tumor necrosis factor;GO:0031667//response to nutrient levels;GO:0009725//response to hormone;GO:0031328//positive regulation of cellular biosynthetic process;GO:0019221//cytokine-mediated signaling pathway;GO:0002687//positive regulation of leukocyte migration","K06490//intercellular adhesion molecule 1","gi|167466198|ref|NP_000192.2|//intercellular adhesion molecule 1 precursor [Homo sapiens]"]
[81619,5394,5.6,11.48,1.03562390973072,7.2863012866242e-19,"Up",2.82666e-20,"TSPAN14","GO:0031224//intrinsic component of membrane","NA","NA","K17296//tetraspanin-14","gi|795446613|ref|XP_011886227.1|//PREDICTED: tetraspanin-14 isoform X1 [Cercocebus atys];gi|724939014|ref|XP_010385611.1|//PREDICTED: tetraspanin-14 [Rhinopithecus roxellana];gi|544457362|ref|XP_005565337.1|//PREDICTED: tetraspanin-14 isoform X2 [Macaca fascicularis];gi|767963925|ref|XP_011538521.1|//PREDICTED: tetraspanin-14 isoform X3 [Homo sapiens];gi|190341022|ref|NP_001121781.1|//tetraspanin-14 isoform 2 [Homo sapiens] ;gi|795517953|ref|XP_011712879.1|//PREDICTED: tetraspanin-14 isoform X3 [Macaca nemestrina];gi|795446622|ref|XP_011886229.1|//PREDICTED: tetraspanin-14 isoform X3 [Cercocebus atys]"]
[255928,6442,2.88,5.9,1.03464614280689,4.6482435029036e-5,"Up",7.41686e-6,"SYT14","GO:0031224//intrinsic component of membrane","NA","NA","K19328//synaptotagmin-14/16","gi|226342955|ref|NP_001139733.1|//synaptotagmin-14 isoform 1 [Homo sapiens];gi|226342957|ref|NP_001139734.1|//synaptotagmin-14 isoform 3 [Homo sapiens];gi|226342962|ref|NP_001139736.1|//synaptotagmin-14 isoform 2 [Homo sapiens];gi|578800788|ref|XP_006711325.1|//PREDICTED: synaptotagmin-14 isoform X1 [Homo sapiens];gi|767908919|ref|XP_011507691.1|//PREDICTED: synaptotagmin-14 isoform X2 [Homo sapiens];gi|144226225|ref|NP_694994.2|//synaptotagmin-14 isoform 4 [Homo sapiens]"]
[205860,1885,16.51,33.76,1.03197478379393,6.92531331543624e-20,"Up",2.54972e-21,"TRIML2","NA","GO:0003824//catalytic activity","NA","K12039//tripartite motif family-like protein 2","gi|694909950|ref|XP_009446991.1|//PREDICTED: probable E3 ubiquitin-protein ligase TRIML2 [Pan troglodytes];gi|742068545|ref|NP_001290348.1|//probable E3 ubiquitin-protein ligase TRIML2 isoform 1 [Homo sapiens];gi|742068547|ref|NP_775824.2|//probable E3 ubiquitin-protein ligase TRIML2 isoform 2 [Homo sapiens] "]
[5352,3941,69.5,141.73,1.02806028300138,1.86684533581395e-158,"Up",4.95888e-161,"PLOD2","GO:0005789//endoplasmic reticulum membrane","GO:0016701//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;GO:0019842//vitamin binding;GO:0046914//transition metal ion binding;GO:0070815//peptidyl-lysine 5-dioxygenase activity","GO:0006950//response to stress;GO:0043412//macromolecule modification","K13645//procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 [EC:1.14.11.4]","gi|62089344|dbj|BAD93116.1|//procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 isoform b variant [Homo sapiens];gi|33636742|ref|NP_891988.1|//procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform 1 precursor [Homo sapiens];gi|562888192|ref|XP_006171469.1|//PREDICTED: procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X1 [Tupaia chinensis];gi|635084815|ref|XP_008007016.1|//PREDICTED: procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 isoform X1 [Chlorocebus sabaeus]"]
[26511,1904,18.13,36.88,1.02445973068518,5.42968016918429e-18,"Up",2.22044e-19,"CHIC2","GO:0016020//membrane","GO:0005488//binding","GO:0006892//post-Golgi vesicle-mediated transport","K12581//CCR4-NOT transcription complex subunit 7/8","gi|327273700|ref|XP_003221618.1|//PREDICTED: cysteine-rich hydrophobic domain 2 protein [Anolis carolinensis];gi|767930684|ref|XP_011532684.1|//PREDICTED: cysteine-rich hydrophobic domain-containing protein 2 isoform X2 [Homo sapiens]"]
[7368,4087,1.61,3.27,1.02222994738347,0.000159246540021045,"Up",2.80462e-5,"UGT8","GO:0031224//intrinsic component of membrane","GO:0035250//UDP-galactosyltransferase activity","GO:0007399//nervous system development","K04628//ceramide galactosyltransferase [EC:2.4.1.47]","gi|40254471|ref|NP_003351.2|//2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor [Homo sapiens];gi|296434442|sp|Q16880.2|CGT_HUMAN//RecName: Full=2-hydroxyacylsphingosine 1-beta-galactosyltransferase; AltName: Full=Ceramide UDP-galactosyltransferase; AltName: Full=Cerebroside synthase; AltName: Full=UDP-galactose-ceramide galactosyltransferase; Flags: Precursor"]
[80045,1688,3.33,6.76,1.02150106921092,0.000219705504885548,"Up",3.97256e-5,"GPR157","GO:0016020//membrane;GO:0031224//intrinsic component of membrane","GO:0004888//transmembrane signaling receptor activity","NA","K08467//G protein-coupled receptor 157","gi|93204873|ref|NP_079256.4|//probable G-protein coupled receptor 157 [Homo sapiens];gi|530360641|ref|XP_005263553.1|//PREDICTED: probable G-protein coupled receptor 157 isoform X1 [Homo sapiens];gi|530360643|ref|XP_005263554.1|//PREDICTED: probable G-protein coupled receptor 157 isoform X2 [Homo sapiens]"]
[966,7651,43.33,87.73,1.01770403194689,5.655677104e-190,"Up",1.048124e-192,"CD59","GO:0046658//anchored component of plasma membrane","GO:0005488//binding","GO:0007165//signal transduction;GO:0007599//hemostasis","K04008//CD59 antigen","gi|795287044|ref|XP_011820940.1|//PREDICTED: CD59 glycoprotein isoform X2 [Mandrillus leucophaeus];gi|10835165|ref|NP_000602.1|//CD59 glycoprotein preproprotein [Homo sapiens];gi|426367909|ref|XP_004050963.1|//PREDICTED: CD59 glycoprotein [Gorilla gorilla gorilla];gi|821015295|ref|XP_012359677.1|//PREDICTED: CD59 glycoprotein isoform X1 [Nomascus leucogenys];gi|119588598|gb|EAW68192.1|//CD59 antigen, complement regulatory protein, isoform CRA_a [Homo sapiens]"]
[403341,6669,2.32,4.69,1.0154631173878,2.87836197019163e-9,"Up",2.50532e-10,"ZBTB34","GO:0031981//nuclear lumen","GO:0046914//transition metal ion binding;GO:0003676//nucleic acid binding","NA","K10508//zinc finger and BTB domain-containing protein 34","gi|544495555|ref|XP_005582249.1|//PREDICTED: zinc finger and BTB domain-containing protein 34 [Macaca fascicularis];gi|530391117|ref|XP_005252046.1|//PREDICTED: zinc finger and BTB domain-containing protein 34 isoform X1 [Homo sapiens]"]
[3428,2793,26.35,53.06,1.00982171370412,7.36747999047619e-41,"Up",1.146902e-42,"IFI16","GO:0031981//nuclear lumen","GO:0043566//structure-specific DNA binding","GO:0008630//intrinsic apoptotic signaling pathway in response to DNA damage;GO:0006351//transcription, DNA-templated;GO:0051707//response to other organism;GO:0002573//myeloid leukocyte differentiation","K20914//gamma-interferon-inducible protein 16","gi|530364640|ref|XP_005245184.1|//PREDICTED: gamma-interferon-inducible protein 16 isoform X1 [Homo sapiens];gi|578800866|ref|XP_006711353.1|//PREDICTED: gamma-interferon-inducible protein 16 isoform X2 [Homo sapiens];gi|330864753|ref|NP_001193496.1|//gamma-interferon-inducible protein 16 isoform 1 [Homo sapiens];gi|62087558|dbj|BAD92226.1|//Interferon, gamma-inducible protein 16 variant [Homo sapiens]"]
[10276,3958,28.15,56.54,1.00613696086358,5.0750745253012e-61,"Up",5.20424e-63,"NET1","GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part","GO:0005088//Ras guanyl-nucleotide exchange factor activity","GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007266//Rho protein signal transduction;GO:0009966//regulation of signal transduction;GO:0016049//cell growth","K20683//Rho guanine nucleotide exchange factor 3/8","gi|62089290|dbj|BAD93089.1|//neuroepithelial cell transforming gene 1 protein variant [Homo sapiens];gi|19923327|ref|NP_005854.2|//neuroepithelial cell-transforming gene 1 protein isoform 2 [Homo sapiens]"]
[28231,3093,27.26,54.72,1.00528266808069,1.20698978575107e-42,"Up",1.737266e-44,"SLCO4A1","GO:0031224//intrinsic component of membrane","GO:0015291//secondary active transmembrane transporter activity","GO:0015711//organic anion transport;GO:0009914//hormone transport;GO:0006575//cellular modified amino acid metabolic process","K14354//solute carrier organic anion transporter family, member 4A","gi|530418673|ref|XP_005260260.1|//PREDICTED: solute carrier organic anion transporter family member 4A1 isoform X5 [Homo sapiens];gi|119595757|gb|EAW75351.1|//solute carrier organic anion transporter family, member 4A1, isoform CRA_c [Homo sapiens];gi|441637989|ref|XP_003280187.2|//PREDICTED: solute carrier organic anion transporter family member 4A1 [Nomascus leucogenys];gi|752424858|ref|XP_011231283.1|//PREDICTED: solute carrier organic anion transporter family member 4A1 [Ailuropoda melanoleuca];gi|768017050|ref|XP_011527094.1|//PREDICTED: solute carrier organic anion transporter family member 4A1 isoform X2 [Homo sapiens];gi|39777594|ref|NP_057438.3|//solute carrier organic anion transporter family member 4A1 [Homo sapiens];gi|675709962|ref|XP_008961462.1|//PREDICTED: solute carrier organic anion transporter family member 4A1 isoform X4 [Pan paniscus]"]
[1843,2040,18.53,37.18,1.00466388889222,4.45641831724138e-21,"Up",1.516856e-22,"DUSP1","GO:0031981//nuclear lumen","GO:0008138//protein tyrosine/serine/threonine phosphatase activity;GO:0004725//protein tyrosine phosphatase activity;GO:0005488//binding","GO:0000165//MAPK cascade;GO:0001704//formation of primary germ layer;GO:0043627//response to estrogen;GO:0000302//response to reactive oxygen species;GO:0031960//response to corticosteroid;GO:0006464//cellular protein modification process;GO:0009314//response to radiation;GO:0033189//response to vitamin A;GO:0006796//phosphate-containing compound metabolic process;GO:0010038//response to metal ion","K21278//dual specificity protein phosphatase 1 [EC:3.1.3.16 3.1.3.48]","gi|4758204|ref|NP_004408.1|//dual specificity protein phosphatase 1 [Homo sapiens]"]
[56652,3297,4.74,9.51,1.0045582819623,3.2582331372973e-7,"Up",3.72358e-8,"C10orf2","GO:0005759//mitochondrial matrix","GO:0043566//structure-specific DNA binding;GO:0032559//adenyl ribonucleotide binding;GO:0019899//enzyme binding;GO:0003678//DNA helicase activity","GO:0006261//DNA-dependent DNA replication;GO:0006351//transcription, DNA-templated;GO:0051259//protein oligomerization","K17680//twinkle protein [EC:3.6.4.12]","gi|255304946|ref|NP_001157284.1|//twinkle protein, mitochondrial isoform B [Homo sapiens] ;gi|39725942|ref|NP_068602.2|//twinkle protein, mitochondrial isoform A [Homo sapiens]"]
[23476,4723,5.3,10.63,1.00407733208054,5.88940091358025e-13,"Up",3.53626e-14,"BRD4","GO:0000228//nuclear chromosome","GO:0005488//binding","GO:0000080//mitotic G1 phase;GO:0000086//G2/M transition of mitotic cell cycle","K11722//bromodomain-containing protein 4","gi|3184498|gb|AAC27978.1|//R31546_1 [Homo sapiens];gi|71052031|gb|AAH35266.1|//BRD4 protein [Homo sapiens];gi|635036679|ref|XP_007993770.1|//PREDICTED: bromodomain-containing protein 4 isoform X1 [Chlorocebus sabaeus]"]
[89795,9771,13.01,26.09,1.00387598209966,4.11641511044776e-71,"Up",3.40746e-73,"NAV3","GO:0031965//nuclear membrane","GO:0032559//adenyl ribonucleotide binding;GO:0016462//pyrophosphatase activity","NA","K19483//neuron navigator 2 [EC:3.6.4.12]","gi|767975818|ref|XP_011537242.1|//PREDICTED: neuron navigator 3 isoform X2 [Homo sapiens];gi|578824416|ref|XP_006719740.1|//PREDICTED: neuron navigator 3 isoform X9 [Homo sapiens];gi|767975827|ref|XP_011537246.1|//PREDICTED: neuron navigator 3 isoform X7 [Homo sapiens];gi|767975820|ref|XP_011537243.1|//PREDICTED: neuron navigator 3 isoform X3 [Homo sapiens];gi|557636663|ref|NP_001019554.1|//neuron navigator 3 isoform 1 [Homo sapiens];gi|120953251|ref|NP_055718.4|//neuron navigator 3 isoform 2 [Homo sapiens] ;gi|530400968|ref|XP_005269272.1|//PREDICTED: neuron navigator 3 isoform X1 [Homo sapiens];gi|767975825|ref|XP_011537245.1|//PREDICTED: neuron navigator 3 isoform X6 [Homo sapiens];gi|675801224|ref|XP_008956593.1|//PREDICTED: neuron navigator 3 isoform X8 [Pan paniscus]"]
[57478,5230,4.7,9.42,1.00306630304778,9.11946892121212e-13,"Up",5.57714e-14,"USP31","NA","GO:0070011//peptidase activity, acting on L-amino acid peptides;GO:0008233//peptidase activity;GO:0016790//thiolester hydrolase activity","GO:0019941//modification-dependent protein catabolic process","K11852//ubiquitin carboxyl-terminal hydrolase 31 [EC:3.4.19.12]","gi|120587027|ref|NP_065769.3|//ubiquitin carboxyl-terminal hydrolase 31 [Homo sapiens];gi|767988703|ref|XP_011544211.1|//PREDICTED: ubiquitin carboxyl-terminal hydrolase 31 isoform X1 [Homo sapiens]"]
[441381,1789,3.1,0.01,-8.27612440527424,6.71979997922078e-11,"Down",4.79452e-12,"LRRC24","GO:0016020//membrane","NA","NA","K07523//netrin-G1 ligand;K19511//peroxidase [EC:1.11.1.7];K16351//netrin-G2 ligand","gi|229089140|ref|NP_001019849.2|//leucine-rich repeat-containing protein 24 precursor [Homo sapiens]"]
[728113,1929,2.32,0.01,-7.85798099512757,1.73971649248895e-9,"Down",1.459436e-10,"ANXA8L1","NA","GO:0046872//metal ion binding;GO:0005543//phospholipid binding","GO:0007599//hemostasis","K17096//annexin A8","gi|194384982|dbj|BAG60903.1|//unnamed protein product [Homo sapiens];gi|524553785|ref|NP_001265853.1|//annexin A8-like protein 1 isoform 2 [Homo sapiens]"]
[100529257,1928,2.31,0.01,-7.85174904141606,8.67241673453094e-9,"Down",8.05204e-10,"SYNJ2BP-COX16","GO:0031224//intrinsic component of membrane;GO:0031966//mitochondrial membrane","NA","NA","K20057//synaptojanin-2-binding protein","gi|321400122|ref|NP_001189478.1|//SYNJ2BP-COX16 protein isoform 3 [Homo sapiens] ;gi|321400120|ref|NP_001189477.1|//SYNJ2BP-COX16 protein isoform 2 [Homo sapiens] ;gi|321400118|ref|NP_001189476.1|//SYNJ2BP-COX16 protein isoform 1 [Homo sapiens] "]
[642778,1167,1.52,0.01,-7.24792751344359,1.88138258754864e-6,"Down",2.3895e-7,"NPIPA3","GO:0005635//nuclear envelope","NA","GO:0050658//RNA transport","K01896//medium-chain acyl-CoA synthetase [EC:6.2.1.2]","gi|472339064|ref|NP_001264252.1|//nuclear pore complex-interacting protein family member A3 [Homo sapiens];gi|767987855|ref|XP_011521050.1|//PREDICTED: nuclear pore complex-interacting protein family member A1 isoform X2 [Homo sapiens];gi|530408895|ref|XP_005255542.1|//PREDICTED: nuclear pore complex-interacting protein family member A3 isoform X10 [Homo sapiens];gi|767987463|ref|XP_011520888.1|//PREDICTED: nuclear pore complex-interacting protein family member A3 isoform X9 [Homo sapiens];gi|767987453|ref|XP_011520883.1|//PREDICTED: nuclear pore complex-interacting protein family member A3 isoform X6 [Homo sapiens];gi|767987459|ref|XP_011520886.1|//PREDICTED: nuclear pore complex-interacting protein family member A3 isoform X7 [Homo sapiens];gi|550540849|sp|E9PIF3.1|NPIA2_HUMAN//RecName: Full=Nuclear pore complex-interacting protein family member A2;gi|767987461|ref|XP_011520887.1|//PREDICTED: nuclear pore complex-interacting protein family member A3 isoform X8 [Homo sapiens]"]
[102723722,1925,1.48,0.01,-7.20945336562895,1.59182227775433e-5,"Down",2.32952e-6,"LOC102723722","GO:0016020//membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0031981//nuclear lumen;GO:0005634//nucleus","GO:0016799//hydrolase activity, hydrolyzing N-glycosyl compounds;GO:0005506//iron ion binding;GO:0004497//monooxygenase activity;GO:0005488//binding","GO:0017144//drug metabolic process;GO:0055114//oxidation-reduction process;GO:0016049//cell growth;GO:0009125//nucleoside monophosphate catabolic process;GO:0090346//cellular organofluorine metabolic process;GO:0000122//negative regulation of transcription from RNA polymerase II promoter;GO:0044092//negative regulation of molecular function;GO:0006721//terpenoid metabolic process;GO:0009698//phenylpropanoid metabolic process;GO:0009820//alkaloid metabolic process;GO:0007599//hemostasis","K06245//laminin, beta 4;K17712//cytochrome P450 family 2 subfamily D polypeptide 6 [EC:1.14.14.1];K12581//CCR4-NOT transcription complex subunit 7/8;K17776//metaxin;K11447//histone demethylase [EC:1.14.11.-];K17985//activating molecule in BECN1-regulated autophagy protein 1;K15696//RING finger protein 113B;K01064//wingless-type MMTV integration site family, member 9","gi|686764753|ref|XP_009232713.1|//PREDICTED: uncharacterized protein LOC100458161 [Pongo abelii];gi|426394656|ref|XP_004063605.1|//PREDICTED: uncharacterized protein LOC101136027 isoform 2 [Gorilla gorilla gorilla]"]
[107987464,2842,1.46,0.01,-7.18982455888002,4.39040697435897e-8,"Down",4.44248e-9,"LOC107987464","GO:0031981//nuclear lumen;GO:0005634//nucleus","GO:0016799//hydrolase activity, hydrolyzing N-glycosyl compounds;GO:0005488//binding","GO:0000122//negative regulation of transcription from RNA polymerase II promoter;GO:0016049//cell growth;GO:0009125//nucleoside monophosphate catabolic process;GO:0007599//hemostasis","K06245//laminin, beta 4;K12581//CCR4-NOT transcription complex subunit 7/8;K11447//histone demethylase [EC:1.14.11.-];K15696//RING finger protein 113B;K17985//activating molecule in BECN1-regulated autophagy protein 1","gi|686764753|ref|XP_009232713.1|//PREDICTED: uncharacterized protein LOC100458161 [Pongo abelii];gi|426394656|ref|XP_004063605.1|//PREDICTED: uncharacterized protein LOC101136027 isoform 2 [Gorilla gorilla gorilla]"]
[284040,2515,1.39,0.01,-7.11894107272351,6.42224702954899e-7,"Down",7.6529e-8,"CDRT4","NA","NA","NA","NA","gi|675681419|ref|XP_008970759.1|//PREDICTED: CMT1A duplicated region transcript 4 protein isoform X1 [Pan paniscus]"]
[100526832,4206,1.27,0.01,-6.98868468677217,1.15054037114094e-10,"Down",8.47198e-12,"PHOSPHO2-KLHL23","NA","NA","NA","K10460//kelch-like protein 23","gi|40255071|ref|NP_653312.2|//kelch-like protein 23 [Homo sapiens]"]
[100533105,4563,1.12,0.01,-6.8073549220576,3.39850358095238e-10,"Down",2.64524e-11,"C8orf44-SGK3","GO:0005768//endosome;GO:0031410//cytoplasmic vesicle","GO:0032559//adenyl ribonucleotide binding;GO:0004672//protein kinase activity;GO:0005543//phospholipid binding","GO:0006464//cellular protein modification process;GO:0050896//response to stimulus","K13304//serum/glucocorticoid-regulated kinase 3 [EC:2.7.11.1]","gi|31563382|ref|NP_037389.4|//serine/threonine-protein kinase Sgk3 isoform 1 [Homo sapiens]"]
[445372,3487,0.87,0.01,-6.44294349584873,5.51739397715852e-6,"Down",7.46082e-7,"TRIM6-TRIM34","GO:0044424//intracellular part","GO:0046914//transition metal ion binding","GO:0051259//protein oligomerization","K11999//tripartite motif-containing protein 6/22/34","gi|51477690|ref|NP_001003819.1|//tripartite motif-containing 6 and tripartite motif-containing 34 [Homo sapiens]"]
[93986,1410,0.81,0.01,-6.33985000288463,2.70213562043796e-5,"Down",4.1163e-6,"FOXP2","GO:0031981//nuclear lumen;GO:0043234//protein complex","GO:0046872//metal ion binding;GO:0043566//structure-specific DNA binding;GO:0000981//RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0042802//identical protein binding;GO:0043565//sequence-specific DNA binding;GO:0046914//transition metal ion binding;GO:0046983//protein dimerization activity","GO:0021543//pallium development;GO:0014706//striated muscle tissue development;GO:0001654//eye development;GO:0007612//learning;GO:0030323//respiratory tube development;GO:0000122//negative regulation of transcription from RNA polymerase II promoter;GO:0060004//reflex;GO:0022037//metencephalon development;GO:0021756//striatum development;GO:0050679//positive regulation of epithelial cell proliferation","K09409//forkhead box protein P","gi|664726516|ref|XP_008520397.1|//PREDICTED: forkhead box protein P2 [Equus przewalskii];gi|110590034|gb|ABG77460.1|//forkhead box P2 variant 3 [Homo sapiens];gi|821101441|ref|XP_012373949.1|//PREDICTED: LOW QUALITY PROTEIN: forkhead box protein P2 [Dasypus novemcinctus]"]
[107986096,3139,0.8,0.01,-6.32192809488736,4.56727654305663e-5,"Down",7.27356e-6,"LOC107986096","NA","NA","NA","NA","gi|558509686|gb|AHA59119.1|//DRG protein long isoform [Homo sapiens]"]
[947,2621,0.73,0.01,-6.18982455888002,0.00062526000295931,"Down",0.0001252992,"CD34","GO:0031224//intrinsic component of membrane;GO:0044424//intracellular part;GO:0009986//cell surface","GO:0043168//anion binding","GO:0007155//cell adhesion;GO:0002682//regulation of immune system process","K06474//CD34 antigen","gi|68342038|ref|NP_001020280.1|//hematopoietic progenitor cell antigen CD34 isoform a precursor [Homo sapiens];gi|426333612|ref|XP_004028369.1|//PREDICTED: hematopoietic progenitor cell antigen CD34 isoform 1 [Gorilla gorilla gorilla]"]
[692312,3270,0.72,0.01,-6.16992500144231,0.000131534594919499,"Down",2.27106e-5,"PPAN-P2RY11","GO:0031981//nuclear lumen","GO:0005488//binding","GO:0006396//RNA processing","K14859//ribosome biogenesis protein SSF1/2","gi|99028871|ref|NP_001035754.1|//PPAN-P2RY11 protein isoform 1 [Homo sapiens];gi|724876757|ref|XP_010372088.1|//PREDICTED: suppressor of SWI4 1 homolog isoform X2 [Rhinopithecus roxellana]"]
[101060351,2915,0.66,0.01,-6.04439411935845,1.5924945e-5,"Down",2.32952e-6,"TBC1D3K","GO:0044464//cell part","NA","NA","K20134//TBC1 domain family member 3","gi|767993168|ref|XP_011522474.1|//PREDICTED: TBC1 domain family member-like isoform X3 [Homo sapiens];gi|612339349|ref|NP_001278393.1|//TBC1 domain family member 3K [Homo sapiens];gi|578831823|ref|XP_006722302.1|//PREDICTED: TBC1 domain family member-like isoform X5 [Homo sapiens];gi|578831815|ref|XP_006722298.1|//PREDICTED: TBC1 domain family member-like isoform X2 [Homo sapiens];gi|767993170|ref|XP_011522475.1|//PREDICTED: TBC1 domain family member-like isoform X4 [Homo sapiens]"]
[101927601,4475,0.45,0.01,-5.49185309632967,0.000625645727822332,"Down",0.0001252992,"GOLGA6L19","NA","NA","NA","K20358//golgin subfamily A member 2","gi|578839978|ref|XP_006725247.1|//PREDICTED: putative golgin subfamily A member 6-like protein 19 [Homo sapiens]"]
[2042,5731,0.39,0.01,-5.28540221886225,0.000131581672440945,"Down",2.27106e-5,"EPHA3","GO:0016021//integral component of membrane","GO:0032559//adenyl ribonucleotide binding;GO:0004714//transmembrane receptor protein tyrosine kinase activity","GO:0006464//cellular protein modification process;GO:0006953//acute-phase response;GO:0002237//response to molecule of bacterial origin;GO:0007167//enzyme linked receptor protein signaling pathway","K05104//Eph receptor A3 [EC:2.7.10.1]","gi|32967314|ref|NP_872585.1|//ephrin type-A receptor 3 isoform b precursor [Homo sapiens];gi|530373627|ref|XP_005264773.1|//PREDICTED: ephrin type-A receptor 3 isoform X2 [Homo sapiens];gi|21361241|ref|NP_005224.2|//ephrin type-A receptor 3 isoform a precursor [Homo sapiens];gi|530373625|ref|XP_005264772.1|//PREDICTED: ephrin type-A receptor 3 isoform X1 [Homo sapiens]"]
[440804,5429,0.35,0.01,-5.12928301694497,0.000625452805920444,"Down",0.0001252992,"RIMBP3B","NA","NA","NA","K19922//peripheral-type benzodiazepine receptor-associated protein 1","gi|191252814|ref|NP_001122107.1|//RIMS-binding protein 3B [Homo sapiens]"]
[107986351,2525,1.13,0.05,-4.49825086752783,1.59115062278481e-5,"Down",2.32952e-6,"LOC107986351","NA","NA","NA","K21125//mucin-5AC;K06568//mucin 1, transmembrane","gi|194382380|dbj|BAG58945.1|//unnamed protein product [Homo sapiens]"]
[646658,5193,0.65,0.03,-4.4374053123073,1.27280210731707e-5,"Down",1.837496e-6,"SYNDIG1L","GO:0016020//membrane","NA","NA","K13443//Niemann-Pick C2 protein","gi|119601581|gb|EAW81175.1|//hCG1786373 [Homo sapiens]"]
[100532731,3388,2.18,0.11,-4.30875270613963,3.37889410404624e-12,"Down",2.1666e-13,"COMMD3-BMI1","NA","NA","NA","K11459//polycomb group RING finger protein 4","gi|323276616|ref|NP_001190991.1|//COMMD3-BMI1 read-through protein [Homo sapiens]"]
[1674,2268,1.37,0.07,-4.29067716090292,3.44459346751189e-5,"Down",5.37074e-6,"DES","GO:0031674//I band;GO:0005882//intermediate filament;GO:0005886//plasma membrane","GO:0005198//structural molecule activity;GO:0005488//binding","GO:0044057//regulation of system process;GO:0006936//muscle contraction;GO:0006996//organelle organization","K07610//desmin","gi|148728589|gb|ABR08708.1|//mutant desmin [Homo sapiens]"]
[84734,969,3.02,0.16,-4.23840473932508,9.31614331933702e-5,"Down",1.562474e-5,"FAM167B","NA","NA","NA","NA","gi|826287892|ref|XP_012497726.1|//PREDICTED: protein FAM167B [Propithecus coquereli]"]
[23639,4180,0.76,0.05,-3.92599941855622,3.44322927207921e-5,"Down",5.37074e-6,"LRRC6","GO:0044424//intracellular part","NA","NA","K19753//protein TilB","gi|821016571|ref|XP_012362185.1|//PREDICTED: protein tilB homolog isoform X1 [Nomascus leucogenys];gi|675793988|ref|XP_008953715.1|//PREDICTED: protein tilB homolog isoform X2 [Pan paniscus];gi|821120459|ref|XP_012383146.1|//PREDICTED: protein tilB homolog [Dasypus novemcinctus];gi|31621309|ref|NP_036604.2|//protein tilB homolog [Homo sapiens];gi|767952775|ref|XP_006716601.2|//PREDICTED: protein tilB homolog isoform X1 [Homo sapiens];gi|634847449|ref|XP_007938766.1|//PREDICTED: protein tilB homolog [Orycteropus afer afer];gi|767952777|ref|XP_011515252.1|//PREDICTED: protein tilB homolog isoform X2 [Homo sapiens];gi|694928334|ref|XP_009454200.1|//PREDICTED: protein tilB homolog isoform X1 [Pan troglodytes]"]
[653,2206,4.08,0.28,-3.86507041991389,1.22504600219539e-13,"Down",6.8941e-15,"BMP5","GO:0044421//extracellular region part","GO:0070696//transmembrane receptor protein serine/threonine kinase binding","GO:0009888//tissue development;GO:0046546//development of primary male sexual characteristics;GO:0048731//system development;GO:0048869//cellular developmental process","K04663//bone morphogenetic protein 5","gi|767940530|ref|XP_011513118.1|//PREDICTED: bone morphogenetic protein 5 isoform X1 [Homo sapiens];gi|635094361|ref|XP_008011855.1|//PREDICTED: bone morphogenetic protein 5 isoform X2 [Chlorocebus sabaeus];gi|982245287|ref|XP_015304772.1|//PREDICTED: bone morphogenetic protein 5 isoform X2 [Macaca fascicularis];gi|767940532|ref|XP_011513119.1|//PREDICTED: bone morphogenetic protein 5 isoform X2 [Homo sapiens]"]
[89874,1770,1.29,0.09,-3.84130225398094,0.000400955545255003,"Down",7.67334e-5,"SLC25A21","GO:0043231//intracellular membrane-bounded organelle;GO:0031224//intrinsic component of membrane;GO:0019866//organelle inner membrane","GO:0005310//dicarboxylic acid transmembrane transporter activity","GO:0006553//lysine metabolic process;GO:0006835//dicarboxylic acid transport","K15110//solute carrier family 25 (mitochondrial 2-oxodicarboxylate transporter), member 21","gi|767981841|ref|XP_011535591.1|//PREDICTED: mitochondrial 2-oxodicarboxylate carrier isoform X3 [Homo sapiens];gi|283837920|ref|NP_001164641.1|//mitochondrial 2-oxodicarboxylate carrier isoform 2 [Homo sapiens];gi|13449279|ref|NP_085134.1|//mitochondrial 2-oxodicarboxylate carrier isoform 1 [Homo sapiens];gi|767981837|ref|XP_011535589.1|//PREDICTED: mitochondrial 2-oxodicarboxylate carrier isoform X1 [Homo sapiens]"]
[9037,11520,1.67,0.12,-3.7987417917529,1.79279194461538e-29,"Down",4.31918e-31,"SEMA5A","GO:0031224//intrinsic component of membrane","GO:0004871//signal transducer activity","GO:0007154//cell communication;GO:0006935//chemotaxis;GO:0048731//system development;GO:0048869//cellular developmental process","K06841//semaphorin 5","gi|147904700|ref|NP_003957.2|//semaphorin-5A precursor [Homo sapiens];gi|767934735|ref|XP_011512461.1|//PREDICTED: semaphorin-5A isoform X2 [Homo sapiens];gi|675701391|ref|XP_008959676.1|//PREDICTED: semaphorin-5A isoform X1 [Pan paniscus]"]
[54065,1209,5.93,0.57,-3.37899828038126,2.59104219262521e-7,"Down",2.90828e-8,"SMIM11A","GO:0031224//intrinsic component of membrane","NA","NA","K12581//CCR4-NOT transcription complex subunit 7/8;K06245//laminin, beta 4;K10807//ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1];K17985//activating molecule in BECN1-regulated autophagy protein 1;K01064//wingless-type MMTV integration site family, member 9","gi|194382524|dbj|BAG64432.1|//unnamed protein product [Homo sapiens];gi|768019932|ref|XP_011544413.1|//PREDICTED: uncharacterized protein LOC102723553 [Homo sapiens]"]
[117283,2324,1.35,0.13,-3.37637587890974,1.89166800500208e-5,"Down",2.80338e-6,"IP6K3","GO:0043231//intracellular membrane-bounded organelle","GO:0032559//adenyl ribonucleotide binding;GO:0051766//inositol trisphosphate kinase activity","GO:0006650//glycerophospholipid metabolic process;GO:0006464//cellular protein modification process;GO:0043647//inositol phosphate metabolic process","K07756//inositol-hexakisphosphate 5-kinase [EC:2.7.4.21]","gi|767939238|ref|XP_011512597.1|//PREDICTED: inositol hexakisphosphate kinase 3 isoform X3 [Homo sapiens];gi|530381450|ref|XP_005248900.1|//PREDICTED: inositol hexakisphosphate kinase 3 isoform X2 [Homo sapiens];gi|55769530|ref|NP_473452.2|//inositol hexakisphosphate kinase 3 [Homo sapiens]"]
[129080,2391,2.13,0.23,-3.21114766416883,4.1093838675921e-7,"Down",4.75468e-8,"EMID1","NA","NA","NA","K19719//collagen, type II, alpha;K16617//collagen, type XIII, alpha;K19721//collagen, type V/XI/XXIV/XXVII, alpha","gi|530419514|ref|XP_005261386.1|//PREDICTED: EMI domain-containing protein 1 isoform X8 [Homo sapiens];gi|795370236|ref|XP_011749019.1|//PREDICTED: EMI domain-containing protein 1 isoform X4 [Macaca nemestrina];gi|768023358|ref|XP_011528175.1|//PREDICTED: EMI domain-containing protein 1 isoform X7 [Homo sapiens];gi|392730058|ref|NP_001254824.1|//EMI domain-containing protein 1 isoform 2 precursor [Homo sapiens];gi|795482266|ref|XP_011893135.1|//PREDICTED: EMI domain-containing protein 1 isoform X5 [Cercocebus atys];gi|28204822|gb|AAH46358.1|//EMI domain containing 1 [Homo sapiens] ;gi|768023352|ref|XP_011528173.1|//PREDICTED: EMI domain-containing protein 1 isoform X5 [Homo sapiens];gi|795370219|ref|XP_011749016.1|//PREDICTED: EMI domain-containing protein 1 isoform X1 [Macaca nemestrina];gi|530419511|ref|XP_005261385.1|//PREDICTED: EMI domain-containing protein 1 isoform X3 [Homo sapiens];gi|768023355|ref|XP_011528174.1|//PREDICTED: EMI domain-containing protein 1 isoform X6 [Homo sapiens];gi|768023350|ref|XP_011528172.1|//PREDICTED: EMI domain-containing protein 1 isoform X4 [Homo sapiens];gi|768023342|ref|XP_011528171.1|//PREDICTED: EMI domain-containing protein 1 isoform X2 [Homo sapiens]"]
[3955,1949,3.3,0.38,-3.11839470080223,7.15455019770115e-10,"Down",5.76766e-11,"LFNG","GO:0031228//intrinsic component of Golgi membrane","GO:0008375//acetylglucosaminyltransferase activity","GO:0009952//anterior/posterior pattern specification;GO:0022602//ovulation cycle process;GO:0009653//anatomical structure morphogenesis;GO:0007126//meiotic nuclear division","K05948//fringe [EC:2.4.1.222]","gi|93140999|ref|NP_001035257.1|//beta-1,3-N-acetylglucosaminyltransferase lunatic fringe isoform a precursor [Homo sapiens];gi|261878556|ref|NP_001159827.1|//beta-1,3-N-acetylglucosaminyltransferase lunatic fringe isoform c [Homo sapiens];gi|694919492|ref|XP_009440769.1|//PREDICTED: beta-1,3-N-acetylglucosaminyltransferase lunatic fringe isoform X1 [Pan troglodytes];gi|58696422|ref|NP_002295.1|//beta-1,3-N-acetylglucosaminyltransferase lunatic fringe isoform d [Homo sapiens]"]
[1299,2485,4.11,0.5,-3.03913839390696,2.72505215581395e-12,"Down",1.737246e-13,"COL9A3","GO:0005576//extracellular region","NA","NA","K08131//collagen, type IX, alpha","gi|821010602|ref|XP_004093017.2|//PREDICTED: collagen alpha-3(IX) chain [Nomascus leucogenys];gi|5712087|gb|AAD47357.1|AF026801_1//alpha-3 type IX collagen [Homo sapiens];gi|768015877|ref|XP_011526847.1|//PREDICTED: collagen alpha-3(IX) chain isoform X3 [Homo sapiens]"]
[9508,5836,1.78,0.24,-2.89077093024524,1.2754411704797e-11,"Down",8.54076e-13,"ADAMTS3","GO:0031012//extracellular matrix","GO:0004175//endopeptidase activity;GO:0005539//glycosaminoglycan binding;GO:0046914//transition metal ion binding","GO:0032963//collagen metabolic process;GO:0030198//extracellular matrix organization;GO:0019538//protein metabolic process","K08619//a disintegrin and metalloproteinase with thrombospondin motifs 3 [EC:3.4.24.-]","gi|767933086|ref|XP_011530723.1|//PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 3 isoform X1 [Homo sapiens];gi|333360873|ref|NP_055058.2|//A disintegrin and metalloproteinase with thrombospondin motifs 3 preproprotein [Homo sapiens]"]
[102724594,992,13.06,1.79,-2.86712340428217,3.39837663880597e-15,"Down",1.687852e-16,"U2AF1L5","GO:0005681//spliceosomal complex;GO:0016604//nuclear body","GO:0046872//metal ion binding;GO:0019904//protein domain specific binding;GO:0046914//transition metal ion binding;GO:0003676//nucleic acid binding","GO:0006396//RNA processing;GO:0006353//DNA-templated transcription, termination;GO:0006397//mRNA processing;GO:0000377//RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;GO:0006405//RNA export from nucleus","K03267//peptide chain release factor subunit 3;K12836//splicing factor U2AF 35 kDa subunit","gi|565321145|gb|ETE71993.1|//Splicing factor U2AF 35 kDa subunit, partial [Ophiophagus hannah];gi|432095948|gb|ELK26863.1|//Splicing factor U2AF 35 kDa subunit [Myotis davidii]"]
[4987,3276,1.01,0.14,-2.85085656069419,0.000215159080588839,"Down",3.88238e-5,"OPRL1","GO:0016021//integral component of membrane","GO:0004985//opioid receptor activity","GO:0050877//neurological system process;GO:0051480//regulation of cytosolic calcium ion concentration;GO:0007188//adenylate cyclase-modulating G-protein coupled receptor signaling pathway","K04216//nociceptin receptor","gi|397477236|ref|XP_003809983.1|//PREDICTED: nociceptin receptor isoform X1 [Pan paniscus];gi|974062106|ref|NP_001305782.1|//nociceptin receptor isoform 1x [Homo sapiens]"]
[3855,1424,2.8,0.39,-2.84388079808272,9.01189429711752e-5,"Down",1.506436e-5,"KRT7","GO:0031981//nuclear lumen;GO:0005882//intermediate filament","GO:0005488//binding","GO:0022403//cell cycle phase;GO:0006412//translation;GO:0051704//multi-organism process;GO:0006259//DNA metabolic process;GO:0006996//organelle organization","K07605//type II keratin, basic","gi|767974195|ref|XP_011536627.1|//PREDICTED: keratin, type II cytoskeletal 7 isoform X1 [Homo sapiens];gi|67782365|ref|NP_005547.3|//keratin, type II cytoskeletal 7 [Homo sapiens]"]
[100271927,2931,3.93,0.56,-2.811030580201,3.40830672e-13,"Down",2.00018e-14,"RASA4B","GO:0016020//membrane;GO:0044444//cytoplasmic part","GO:0043169//cation binding;GO:0008047//enzyme activator activity","GO:0009966//regulation of signal transduction","K17630//Ras GTPase-activating protein 4","gi|300681236|sp|C9J798.2|RAS4B_HUMAN//RecName: Full=Ras GTPase-activating protein 4B;gi|530385361|ref|XP_005250142.1|//PREDICTED: putative Ras GTPase-activating protein 4B isoform X2 [Homo sapiens];gi|84570051|gb|AAI10874.1|//RAS p21 protein activator 4 [Homo sapiens];gi|472824974|ref|NP_001264264.1|//ras GTPase-activating protein 4B [Homo sapiens];gi|767946584|ref|XP_011513992.1|//PREDICTED: putative Ras GTPase-activating protein 4B isoform X3 [Homo sapiens]"]
[84913,3317,2.76,0.4,-2.78659636189081,7.48448299315068e-11,"Down",5.40022e-12,"ATOH8","NA","NA","GO:0032502//developmental process","K09084//atonal protein 8","gi|767915338|ref|XP_011531441.1|//PREDICTED: protein atonal homolog 8 isoform X1 [Homo sapiens];gi|578803229|ref|XP_006712185.1|//PREDICTED: protein atonal homolog 8 isoform X2 [Homo sapiens];gi|767915342|ref|XP_011531442.1|//PREDICTED: protein atonal homolog 8 isoform X3 [Homo sapiens]"]
[83937,3290,1.36,0.2,-2.76553474636298,0.000194898832678387,"Down",3.49272e-5,"RASSF4","NA","GO:0005488//binding","GO:0023052//signaling;GO:0009987//cellular process","K09851//Ras association domain-containing protein 2/4","gi|530392713|ref|XP_005271890.1|//PREDICTED: ras association domain-containing protein 4 isoform X5 [Homo sapiens];gi|28932869|gb|AAO61140.1|//putative tumor suppressor RASSF4 isoform C [Homo sapiens];gi|767964016|ref|XP_011538555.1|//PREDICTED: ras association domain-containing protein 4 isoform X2 [Homo sapiens];gi|829978202|ref|XP_012606546.1|//PREDICTED: ras association domain-containing protein 4 isoform X1 [Microcebus murinus];gi|578819880|ref|XP_006718076.1|//PREDICTED: ras association domain-containing protein 4 isoform X3 [Homo sapiens];gi|23510360|ref|NP_114412.2|//ras association domain-containing protein 4 [Homo sapiens];gi|62088472|dbj|BAD92683.1|//Ras association domain family 4 isoform a variant [Homo sapiens]"]
[27075,1912,1.63,0.25,-2.70487196445635,0.000788317068755649,"Down",0.0001616274,"TSPAN13","GO:0016021//integral component of membrane","NA","NA","K17356//tetraspanin-13/31","gi|635114429|ref|XP_007980163.1|//PREDICTED: tetraspanin-13 [Chlorocebus sabaeus]"]
[7114,657,306.58,48.13,-2.67125525624614,1.27464312e-201,"Down",2.20472e-204,"TMSB4X","GO:0031091//platelet alpha granule;GO:0043232//intracellular non-membrane-bounded organelle","GO:0008092//cytoskeletal protein binding","GO:0001775//cell activation;GO:0016477//cell migration;GO:0030837//negative regulation of actin filament polymerization;GO:0007599//hemostasis","K05764//thymosin, beta 4","gi|795629722|ref|XP_011733703.1|//PREDICTED: thymosin beta-4 [Macaca nemestrina]"]
[192668,2719,2.72,0.46,-2.56390088519333,8.08101139823009e-8,"Down",8.4614e-9,"CYS1","GO:0044424//intracellular part","NA","NA","NA","gi|81158080|ref|NP_001032237.1|//cystin-1 [Homo sapiens]"]
[1534,2929,2.65,0.46,-2.52628659339355,2.21340085279188e-8,"Down",2.15488e-9,"CYB561","GO:0016021//integral component of membrane","GO:0043169//cation binding;GO:0016653//oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor;GO:0016723//oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor","GO:0006091//generation of precursor metabolites and energy;GO:0051234//establishment of localization","K08360//cytochrome b-561 [EC:1.16.5.1]","gi|426347091|ref|XP_004041192.1|//PREDICTED: cytochrome b561-like [Gorilla gorilla gorilla];gi|221040132|dbj|BAH11829.1|//unnamed protein product [Homo sapiens];gi|426347093|ref|XP_004041193.1|//PREDICTED: cytochrome b561-like [Gorilla gorilla gorilla]"]
[57124,2576,2.04,0.36,-2.50250034052918,1.48129124681934e-5,"Down",2.1577e-6,"CD248","GO:0031012//extracellular matrix;GO:0031224//intrinsic component of membrane;GO:0044424//intracellular part","GO:0030246//carbohydrate binding;GO:0046872//metal ion binding","NA","K06706//CD248 antigen, endosialin","gi|9966885|ref|NP_065137.1|//endosialin precursor [Homo sapiens]"]
[50855,1227,3.62,0.64,-2.49984588708321,5.57876482317073e-5,"Down",9.04292e-6,"PARD6A","GO:0043231//intracellular membrane-bounded organelle;GO:0031252//cell leading edge;GO:0043296//apical junction complex;GO:0044444//cytoplasmic part","GO:0017016//Ras GTPase binding","GO:0007043//cell-cell junction assembly;GO:0034331//cell junction maintenance","K06093//partitioning defective protein 6","gi|635033601|ref|XP_007992135.1|//PREDICTED: partitioning defective 6 homolog alpha isoform X1 [Chlorocebus sabaeus];gi|530423961|ref|XP_005256034.1|//PREDICTED: partitioning defective 6 homolog alpha isoform X3 [Homo sapiens];gi|119603558|gb|EAW83152.1|//hCG2025821, isoform CRA_b [Homo sapiens];gi|675716891|ref|XP_008962836.1|//PREDICTED: partitioning defective 6 homolog alpha isoform X3 [Pan paniscus];gi|675716887|ref|XP_008962835.1|//PREDICTED: partitioning defective 6 homolog alpha isoform X2 [Pan paniscus]"]
[10484,3322,78.85,14.16,-2.47728948959488,5.54219184e-245,"Down",6.50492e-248,"SEC23A","GO:0005789//endoplasmic reticulum membrane;GO:0012507//ER to Golgi transport vesicle membrane","GO:0046914//transition metal ion binding","GO:0048193//Golgi vesicle transport;GO:0006901//vesicle coating;GO:0006487//protein N-linked glycosylation;GO:0015031//protein transport","K14006//protein transport protein SEC23","gi|209870512|pdb|3EG9|A//Chain A, Crystal Structure Of The Mammalian Copii-coat Protein Sec23/24 Bound To The Transport Signal Sequence Of Membrin;gi|530402948|ref|XP_005267319.1|//PREDICTED: protein transport protein Sec23A isoform X1 [Homo sapiens];gi|767979537|ref|XP_011534657.1|//PREDICTED: protein transport protein Sec23A isoform X2 [Homo sapiens]"]
[6623,819,6.03,1.12,-2.42865926984248,3.39063732909885e-5,"Down",5.27614e-6,"SNCG","GO:0044297//cell body;GO:0015630//microtubule cytoskeleton;GO:0044444//cytoplasmic part;GO:0043005//neuron projection","GO:0005488//binding","GO:0007626//locomotory behavior;GO:0050804//modulation of synaptic transmission","K04528//alpha-synuclein","gi|635053430|ref|XP_007960887.1|//PREDICTED: gamma-synuclein isoform X1 [Chlorocebus sabaeus]"]
[374462,8066,1.83,0.34,-2.4282369970337,3.51394482580645e-14,"Down",1.884176e-15,"PTPRQ","NA","NA","NA","K16910//receptor-type tyrosine-protein phosphatase Q [EC:3.1.3.48]","gi|795592681|ref|XP_011725340.1|//PREDICTED: phosphatidylinositol phosphatase PTPRQ [Macaca nemestrina];gi|222537743|ref|NP_001138498.1|//phosphatidylinositol phosphatase PTPRQ precursor [Homo sapiens];gi|795125647|ref|XP_011789501.1|//PREDICTED: phosphatidylinositol phosphatase PTPRQ isoform X1 [Colobus angolensis palliatus]"]
[93210,2598,2.54,0.48,-2.40372218605101,2.55719402004773e-6,"Down",3.30944e-7,"PGAP3","GO:0031224//intrinsic component of membrane;GO:0005789//endoplasmic reticulum membrane","GO:0016787//hydrolase activity","GO:0006497//protein lipidation;GO:0046488//phosphatidylinositol metabolic process","NA","gi|767996502|ref|XP_011523782.1|//PREDICTED: post-GPI attachment to proteins factor 3 isoform X1 [Homo sapiens];gi|619328895|ref|NP_001278657.1|//post-GPI attachment to proteins factor 3 isoform 3 precursor [Homo sapiens] ;gi|119580993|gb|EAW60589.1|//per1-like domain containing 1, isoform CRA_a [Homo sapiens];gi|511889979|ref|XP_004764702.1|//PREDICTED: post-GPI attachment to proteins factor 3 isoform X2 [Mustela putorius furo];gi|332258382|ref|XP_003278279.1|//PREDICTED: post-GPI attachment to proteins factor 3 isoform X3 [Nomascus leucogenys];gi|55645329|ref|XP_511460.1|//PREDICTED: post-GPI attachment to proteins factor 3 isoform X1 [Pan troglodytes]"]
[102724788,2048,5.04,0.96,-2.39231742277876,4.49326918518519e-11,"Down",3.14762e-12,"LOC102724788","GO:0044429//mitochondrial part;GO:0019866//organelle inner membrane","GO:0016645//oxidoreductase activity, acting on the CH-NH group of donors","GO:0006536//glutamate metabolic process;GO:0006560//proline metabolic process","K00318//proline dehydrogenase [EC:1.5.-.-]","gi|63102259|gb|AAH94736.1|//PRODH protein, partial [Homo sapiens];gi|578839221|ref|XP_006724998.1|//PREDICTED: proline dehydrogenase 1, mitochondrial isoform X1 [Homo sapiens]"]
[130814,1854,5.4,1.04,-2.37637587890974,2.11351043765387e-9,"Down",1.803038e-10,"PQLC3","GO:0016020//membrane;GO:0031224//intrinsic component of membrane","NA","NA","K12581//CCR4-NOT transcription complex subunit 7/8;K09660//mannose-P-dolichol utilization defect 1","gi|675724610|ref|XP_008979378.1|//PREDICTED: PQ-loop repeat-containing protein 3, partial [Callithrix jacchus];gi|22748837|ref|NP_689604.1|//PQ-loop repeat-containing protein 3 isoform a precursor [Homo sapiens];gi|544186042|ref|NP_001269639.1|//PQ-loop repeat-containing protein 3 isoform b [Homo sapiens]"]
[9881,7836,0.62,0.12,-2.36923380966572,0.000124460233501078,"Down",2.13892e-5,"TRANK1","NA","GO:0032559//adenyl ribonucleotide binding;GO:0003678//DNA helicase activity;GO:0003676//nucleic acid binding","GO:0006259//DNA metabolic process","K11807//WD and tetratricopeptide repeats protein 1;K09553//stress-induced-phosphoprotein 1","gi|767924742|ref|XP_011532594.1|//PREDICTED: TPR and ankyrin repeat-containing protein 1 isoform X4 [Homo sapiens];gi|694900902|ref|XP_009443427.1|//PREDICTED: TPR and ankyrin repeat-containing protein 1 isoform X1 [Pan troglodytes];gi|966928219|ref|XP_002808376.2|//PREDICTED: TPR and ankyrin repeat-containing protein 1 [Macaca mulatta];gi|257467636|ref|NP_055646.2|//TPR and ankyrin repeat-containing protein 1 [Homo sapiens];gi|767924735|ref|XP_011532591.1|//PREDICTED: TPR and ankyrin repeat-containing protein 1 isoform X1 [Homo sapiens]"]
[875,2624,3.53,0.7,-2.33424135632621,4.03297617112299e-7,"Down",4.6588e-8,"CBS","GO:0031981//nuclear lumen;GO:0044444//cytoplasmic part","GO:0016836//hydro-lyase activity;GO:0005506//iron ion binding;GO:0042802//identical protein binding;GO:0048037//cofactor binding;GO:0019899//enzyme binding","GO:0009991//response to extracellular stimulus;GO:0001101//response to acid chemical;GO:0019344//cysteine biosynthetic process;GO:0009093//cysteine catabolic process;GO:0043405//regulation of MAP kinase activity;GO:0001503//ossification;GO:0006563//L-serine metabolic process","K01697//cystathionine beta-synthase [EC:4.2.1.22]","gi|795585984|ref|XP_011724241.1|//PREDICTED: cystathionine beta-synthase isoform X1 [Macaca nemestrina];gi|768021841|ref|XP_011528075.1|//PREDICTED: cystathionine beta-synthase isoform X1 [Homo sapiens];gi|3776243|gb|AAC64684.1|//cystathionine beta-synthase minor isoform [Homo sapiens];gi|768021849|ref|XP_011528077.1|//PREDICTED: cystathionine beta-synthase isoform X2 [Homo sapiens];gi|768019778|ref|XP_011544403.1|//PREDICTED: cystathionine beta-synthase isoform X3 [Homo sapiens];gi|685528712|ref|XP_009200453.1|//PREDICTED: cystathionine beta-synthase isoform X1 [Papio anubis]"]
[146433,1817,2.29,0.48,-2.25424128737579,0.000294176672981988,"Down",5.44812e-5,"IL34","GO:0044421//extracellular region part","GO:0005126//cytokine receptor binding","GO:0001932//regulation of protein phosphorylation;GO:0008283//cell proliferation","NA","gi|289666750|ref|NP_001166242.1|//interleukin-34 isoform 2 precursor [Homo sapiens] ;gi|289666748|ref|NP_689669.2|//interleukin-34 isoform 1 precursor [Homo sapiens]"]
[170689,5676,1.02,0.22,-2.2129937233342,5.94271938125569e-6,"Down",8.069e-7,"ADAMTS15","GO:0031012//extracellular matrix","GO:0004175//endopeptidase activity;GO:0046914//transition metal ion binding","GO:0019538//protein metabolic process","K08629//a disintegrin and metalloproteinase with thrombospondin motifs 15 [EC:3.4.24.-]","gi|21265058|ref|NP_620686.1|//A disintegrin and metalloproteinase with thrombospondin motifs 15 preproprotein [Homo sapiens]"]
[3417,2404,35.76,7.83,-2.19126252389228,4.66706035555555e-71,"Down",3.8921e-73,"IDH1","GO:0044439//peroxisomal part","GO:0004448//isocitrate dehydrogenase activity;GO:0046872//metal ion binding;GO:0000166//nucleotide binding;GO:0042802//identical protein binding","GO:0006790//sulfur compound metabolic process;GO:0043648//dicarboxylic acid metabolic process;GO:0006950//response to stress;GO:0044262//cellular carbohydrate metabolic process;GO:0009060//aerobic respiration;GO:0008406//gonad development;GO:0009725//response to hormone;GO:0006629//lipid metabolic process","K00031//isocitrate dehydrogenase [EC:1.1.1.42]","gi|28178825|ref|NP_005887.2|//isocitrate dehydrogenase [NADP] cytoplasmic [Homo sapiens]"]
[8344,435,25.83,5.75,-2.16741378228626,2.54359019613457e-9,"Down",2.19508e-10,"HIST1H2BE","GO:0043231//intracellular membrane-bounded organelle;GO:0000785//chromatin","GO:0003676//nucleic acid binding","GO:0034728//nucleosome organization","K11252//histone H2B","gi|537251205|gb|ERE88448.1|//Histone H2B containing protein [Cricetulus griseus]"]
[2674,9597,0.81,0.19,-2.09192248944104,1.54141848639053e-6,"Down",1.931058e-7,"GFRA1","GO:0031224//intrinsic component of membrane","GO:0004896//cytokine receptor activity;GO:0005102//receptor binding","GO:0007165//signal transduction;GO:0006935//chemotaxis;GO:0048731//system development","K19895//GDNF family receptor alpha 1","gi|795311160|ref|XP_011715058.1|//PREDICTED: GDNF family receptor alpha-1 isoform X1 [Macaca nemestrina];gi|795311169|ref|XP_011715065.1|//PREDICTED: GDNF family receptor alpha-1 isoform X2 [Macaca nemestrina]"]
[2044,5812,2.22,0.53,-2.06649541178691,1.40237101896839e-10,"Down",1.041296e-11,"EPHA5","GO:0005783//endoplasmic reticulum;GO:0009986//cell surface;GO:0044297//cell body;GO:0016021//integral component of membrane;GO:0043005//neuron projection","GO:0032559//adenyl ribonucleotide binding;GO:0005003//ephrin receptor activity","GO:0019935//cyclic-nucleotide-mediated signaling;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0006464//cellular protein modification process;GO:0048468//cell development","K05106//Eph receptor A5 [EC:2.7.10.1];K05107//Eph receptor A6 [EC:2.7.10.1]","gi|221625401|ref|NP_004430.4|//ephrin type-A receptor 5 isoform a [Homo sapiens];gi|528881089|ref|NP_001268694.1|//ephrin type-A receptor 5 isoform c [Homo sapiens];gi|530376907|ref|XP_005265710.1|//PREDICTED: ephrin type-A receptor 5 isoform X3 [Homo sapiens];gi|62088330|dbj|BAD92612.1|//ephrin receptor EphA5 isoform a variant [Homo sapiens];gi|674050529|ref|XP_008831483.1|//PREDICTED: ephrin type-A receptor 5 isoform X8 [Nannospalax galili];gi|694907677|ref|XP_009446097.1|//PREDICTED: ephrin type-A receptor 5 isoform X6 [Pan troglodytes];gi|767931381|ref|XP_011530037.1|//PREDICTED: ephrin type-A receptor 5 isoform X2 [Homo sapiens];gi|528881274|ref|NP_001268695.1|//ephrin type-A receptor 5 isoform d [Homo sapiens];gi|221625422|ref|NP_872272.2|//ephrin type-A receptor 5 isoform b [Homo sapiens]"]
[653145,2046,11.72,2.81,-2.06033053420132,3.74201256136364e-17,"Down",1.627364e-18,"ANXA8","NA","GO:0046872//metal ion binding;GO:0005488//binding;GO:0005543//phospholipid binding","GO:0007599//hemostasis","K17096//annexin A8","gi|767963625|ref|XP_011538403.1|//PREDICTED: annexin A8 isoform X11 [Homo sapiens];gi|767963618|ref|XP_011538400.1|//PREDICTED: annexin A8 isoform X7 [Homo sapiens];gi|411147376|ref|NP_001258632.1|//annexin A8 isoform 3 [Homo sapiens] ;gi|767963620|ref|XP_011538401.1|//PREDICTED: annexin A8 isoform X8 [Homo sapiens];gi|194384982|dbj|BAG60903.1|//unnamed protein product [Homo sapiens];gi|767963611|ref|XP_011538398.1|//PREDICTED: annexin A8 isoform X5 [Homo sapiens]"]
[11037,5651,3.23,0.8,-2.01346225980656,1.19767692673267e-13,"Down",6.72528e-15,"STON1","GO:0030119//AP-type membrane coat adaptor complex","NA","GO:0006897//endocytosis;GO:0015031//protein transport","K20067//stonin-1/2","gi|26787993|ref|NP_006864.2|//stonin-1 [Homo sapiens]"]
[253832,5327,19.5,4.88,-1.99852107107409,1.77729364540541e-77,"Down",1.218678e-79,"ZDHHC20","GO:0031224//intrinsic component of membrane","GO:0046914//transition metal ion binding;GO:0016747//transferase activity, transferring acyl groups other than amino-acyl groups","NA","K20028//palmitoyltransferase ZDHHC2/15/20 [EC:2.3.1.225]","gi|767977543|ref|XP_011533331.1|//PREDICTED: probable palmitoyltransferase ZDHHC20 isoform X4 [Homo sapiens];gi|767977546|ref|XP_011533332.1|//PREDICTED: probable palmitoyltransferase ZDHHC20 isoform X5 [Homo sapiens];gi|982307572|ref|XP_015294537.1|//PREDICTED: probable palmitoyltransferase ZDHHC20 isoform X5 [Macaca fascicularis];gi|119628715|gb|EAX08310.1|//zinc finger, DHHC-type containing 20, isoform CRA_d [Homo sapiens]"]
[57484,6262,3.46,0.88,-1.97519660899943,2.06817975384615e-16,"Down",9.46702e-18,"RNF150","GO:0031224//intrinsic component of membrane","GO:0046914//transition metal ion binding","NA","K15701//E3 ubiquitin-protein ligase RNF130 [EC:2.3.2.27]","gi|767932404|ref|XP_011530450.1|//PREDICTED: RING finger protein 150 isoform X3 [Homo sapiens];gi|6330555|dbj|BAA86528.1|//KIAA1214 protein [Homo sapiens];gi|530378008|ref|XP_005263207.1|//PREDICTED: RING finger protein 150 isoform X1 [Homo sapiens];gi|767932402|ref|XP_011530449.1|//PREDICTED: RING finger protein 150 isoform X2 [Homo sapiens]"]
[122953,2008,25.2,6.41,-1.97502747176854,1.77263505454545e-36,"Down",3.25224e-38,"JDP2","NA","NA","NA","K09033//jun dimerization protein 2","gi|591339176|ref|XP_007095104.1|//PREDICTED: jun dimerization protein 2 isoform X2 [Panthera tigris altaica];gi|694957062|ref|XP_009426442.1|//PREDICTED: jun dimerization protein 2 isoform X1 [Pan troglodytes];gi|795448396|ref|XP_011763810.1|//PREDICTED: jun dimerization protein 2 isoform X1 [Macaca nemestrina];gi|205277421|ref|NP_001128521.1|//jun dimerization protein 2 isoform b [Homo sapiens] "]
[115948,2012,2.9,0.74,-1.97045572438598,7.01055595505618e-5,"Down",1.1563e-5,"CCDC151","NA","NA","NA","K10352//myosin heavy chain;K17639//ral guanine nucleotide dissociation stimulator-like 3;K16754//coiled-coil domain-containing protein 41","gi|698320880|ref|NP_001289383.1|//coiled-coil domain-containing protein 151 isoform 3 [Homo sapiens];gi|698320878|ref|NP_001289382.1|//coiled-coil domain-containing protein 151 isoform 2 [Homo sapiens] ;gi|117553613|ref|NP_659482.3|//coiled-coil domain-containing protein 151 isoform 1 [Homo sapiens]"]
[7318,3206,1.41,0.36,-1.96962635095648,0.000465178326926737,"Down",9.06046e-5,"UBA7","GO:0044444//cytoplasmic part","GO:0008641//small protein activating enzyme activity;GO:0032559//adenyl ribonucleotide binding","GO:0051603//proteolysis involved in cellular protein catabolic process;GO:0006464//cellular protein modification process;GO:0001818//negative regulation of cytokine production","K10698//ubiquitin-activating enzyme E1-like [EC:6.2.1.45]","gi|767924182|ref|XP_011532373.1|//PREDICTED: ubiquitin-like modifier-activating enzyme 7 isoform X4 [Homo sapiens];gi|477152|pir||A48195//ubiquitin-protein ligase E1 homolog - human;gi|38045948|ref|NP_003326.2|//ubiquitin-like modifier-activating enzyme 7 [Homo sapiens];gi|578806537|ref|XP_006713384.1|//PREDICTED: ubiquitin-like modifier-activating enzyme 7 isoform X1 [Homo sapiens]"]
[1545,5160,0.92,0.24,-1.93859945533586,0.00055055893875,"Down",0.000108833,"CYP1B1","GO:0043231//intracellular membrane-bounded organelle;GO:0031090//organelle membrane","GO:0005506//iron ion binding;GO:0016712//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen","GO:0008202//steroid metabolic process;GO:0042221//response to chemical;GO:0050953//sensory perception of light stimulus;GO:0044237//cellular metabolic process;GO:0019748//secondary metabolic process","K07410//cytochrome P450 family 1 subfamily B polypeptide 1 [EC:1.14.14.1]","gi|189491763|ref|NP_000095.2|//cytochrome P450 1B1 [Homo sapiens]"]
[6845,2655,96.53,25.22,-1.93640910324336,5.09037056e-181,"Down",1.037696e-183,"VAMP7","GO:0031224//intrinsic component of membrane;GO:0005770//late endosome;GO:0030666//endocytic vesicle membrane;GO:0030133//transport vesicle;GO:0043234//protein complex;GO:0005764//lysosome","GO:0005488//binding","GO:0007041//lysosomal transport;GO:0048193//Golgi vesicle transport;GO:0002283//neutrophil activation involved in immune response;GO:0002278//eosinophil activation involved in immune response;GO:0006887//exocytosis;GO:0006909//phagocytosis","K08515//vesicle-associated membrane protein 7","gi|297747292|ref|NP_001172112.1|//vesicle-associated membrane protein 7 isoform 3 [Homo sapiens]"]
[102723996,3398,1.68,0.44,-1.93288580414146,0.000214984401369863,"Down",3.8779e-5,"LOC102723996","GO:0031224//intrinsic component of membrane","GO:0005515//protein binding","GO:0031294//lymphocyte costimulation;GO:0006970//response to osmotic stress;GO:0042102//positive regulation of T cell proliferation;GO:0023052//signaling","K06710//inducible T-cell co-stimulator ligand","gi|3327120|dbj|BAA31628.1|//KIAA0653 protein [Homo sapiens];gi|768019563|ref|XP_011544380.1|//PREDICTED: ICOS ligand isoform X2 [Homo sapiens]"]
[51622,1834,14.6,3.85,-1.92303801818512,5.24677984615385e-19,"Down",2.02248e-20,"CCZ1","GO:0005764//lysosome","NA","NA","K08269//serine/threonine-protein kinase ULK/ATG1 [EC:2.7.11.1]","gi|37674289|ref|NP_932765.1|//vacuolar fusion protein CCZ1 homolog B [Homo sapiens]"]
[84709,1339,86.5,23.06,-1.90730761975968,1.7309419917757e-79,"Down",1.144124e-81,"MGARP","GO:0031224//intrinsic component of membrane","NA","NA","K04727//programmed cell death 8 (apoptosis-inducing factor) [EC:1.-.-.-]","gi|12584947|gb|AAG59896.1|AF329088_1//ovary-specific acidic protein [Homo sapiens]"]
[219539,2347,3.02,0.81,-1.89855473644045,0.000173392345289602,"Down",3.06982e-5,"YPEL4","GO:0031981//nuclear lumen","NA","NA","NA","gi|537146482|gb|ERE69964.1|//protein yippee-like 4-like protein [Cricetulus griseus]"]
[317749,1384,4.51,1.21,-1.89812038598079,5.73455131584949e-5,"Down",9.32024e-6,"DHRS4L2","GO:0005635//nuclear envelope;GO:0042579//microbody;GO:0044444//cytoplasmic part","GO:0016620//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor;GO:0016616//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0016491//oxidoreductase activity","GO:0001523//retinoid metabolic process;GO:0008152//metabolic process","K11147//dehydrogenase/reductase SDR family member 4 [EC:1.1.-.-];K11148//dehydrogenase/reductase SDR family member 4-like protein 2 [EC:1.1.-.-]","gi|119586528|gb|EAW66124.1|//hCG2045881 [Homo sapiens];gi|4105190|gb|AAD02292.1|//peroxisomal short-chain alcohol dehydrogenase [Homo sapiens];gi|291294376|gb|ADD92526.1|//dehydrogenase/reductase (SDR family) member 4 like 2A3 [Homo sapiens];gi|694955418|ref|XP_009425811.1|//PREDICTED: dehydrogenase/reductase SDR family member 4 isoform X3 [Pan troglodytes]"]
[83849,2412,1.52,0.41,-1.8903755088255,9.4378601958042e-5,"Down",1.584054e-5,"SYT15","GO:0016020//membrane;GO:0031224//intrinsic component of membrane","NA","NA","K19914//synaptotagmin-15","gi|332265985|ref|XP_003281994.1|//PREDICTED: synaptotagmin-15 isoform X2 [Nomascus leucogenys];gi|767964524|ref|XP_011538741.1|//PREDICTED: synaptotagmin-15 isoform X6 [Homo sapiens];gi|578820089|ref|XP_006718157.1|//PREDICTED: synaptotagmin-15 isoform X4 [Homo sapiens];gi|332265987|ref|XP_003281995.1|//PREDICTED: synaptotagmin-15 isoform X1 [Nomascus leucogenys];gi|578820085|ref|XP_006718156.1|//PREDICTED: synaptotagmin-15 isoform X2 [Homo sapiens]"]
[6342,2032,51.66,14.04,-1.87950470781344,2.82308665341615e-62,"Down",2.80774e-64,"SCP2","GO:0031981//nuclear lumen;GO:0044439//peroxisomal part","GO:0016408//C-acyltransferase activity;GO:0005496//steroid binding","GO:0006694//steroid biosynthetic process;GO:0006635//fatty acid beta-oxidation;GO:0010876//lipid localization;GO:0006996//organelle organization;GO:0051234//establishment of localization","K08764//sterol carrier protein 2 [EC:2.3.1.176]","gi|62087158|dbj|BAD92026.1|//sterol carrier protein X isoform 1 proprotein variant [Homo sapiens];gi|302344760|ref|NP_001180528.1|//non-specific lipid-transfer protein isoform 7 [Homo sapiens];gi|302344762|ref|NP_001180529.1|//non-specific lipid-transfer protein isoform 6 [Homo sapiens];gi|19923233|ref|NP_002970.2|//non-specific lipid-transfer protein isoform 1 precursor [Homo sapiens];gi|795441338|ref|XP_011762534.1|//PREDICTED: non-specific lipid-transfer protein isoform X2 [Macaca nemestrina];gi|432977|gb|AAA03558.1|//sterol carrier protein-2 [Homo sapiens];gi|767905523|ref|XP_011540237.1|//PREDICTED: non-specific lipid-transfer protein isoform X2 [Homo sapiens];gi|119627167|gb|EAX06762.1|//sterol carrier protein 2, isoform CRA_b [Homo sapiens]"]
[85462,6598,1.43,0.39,-1.87446911791614,4.68858525515055e-7,"Down",5.48276e-8,"FHDC1","NA","GO:0008092//cytoskeletal protein binding","GO:0016043//cellular component organization;GO:0007010//cytoskeleton organization","K01939//adenylosuccinate synthase [EC:6.3.4.4];K04512//dishevelled associated activator of morphogenesis","gi|145309324|ref|NP_203751.2|//FH2 domain-containing protein 1 [Homo sapiens]"]
[23098,7305,4.47,1.22,-1.87339368362043,6.94265268525896e-23,"Down",2.15296e-24,"SARM1","GO:0044424//intracellular part;GO:0044425//membrane part","GO:0004872//receptor activity","GO:0006952//defense response;GO:0023052//signaling","K14613//MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1","gi|635088676|ref|XP_008008963.1|//PREDICTED: sterile alpha and TIR motif-containing protein 1 [Chlorocebus sabaeus]"]
[90355,3089,5.04,1.38,-1.86875546672175,1.23323865551839e-10,"Down",9.1114e-12,"C5orf30","NA","NA","NA","NA","gi|15082242|ref|NP_149988.1|//UNC119-binding protein C5orf30 [Homo sapiens]"]
[55536,2895,20.86,5.73,-1.86413211376286,1.13050226865672e-39,"Down",1.8716e-41,"CDCA7L","GO:0031981//nuclear lumen","NA","GO:0008283//cell proliferation","K10408//dynein heavy chain, axonemal","gi|635114294|ref|XP_007980100.1|//PREDICTED: cell division cycle-associated 7-like protein isoform X4 [Chlorocebus sabaeus];gi|635114292|ref|XP_007980099.1|//PREDICTED: cell division cycle-associated 7-like protein isoform X3 [Chlorocebus sabaeus]"]
[1281,5490,33.33,9.16,-1.8634018140133,3.0574443062069e-124,"Down",1.095452e-126,"COL3A1","GO:0005583//fibrillar collagen trimer","GO:0005198//structural molecule activity;GO:0019838//growth factor binding;GO:0005102//receptor binding","GO:0009611//response to wounding;GO:0002683//negative regulation of immune system process;GO:0031589//cell-substrate adhesion;GO:0007178//transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0009628//response to abiotic stimulus;GO:0001775//cell activation;GO:0008544//epidermis development;GO:0006464//cellular protein modification process;GO:0010033//response to organic substance;GO:0030198//extracellular matrix organization;GO:0009059//macromolecule biosynthetic process;GO:0006935//chemotaxis","K19720//collagen, type III, alpha","gi|4502951|ref|NP_000081.1|//collagen alpha-1(III) chain preproprotein [Homo sapiens]"]
[55260,2577,2.59,0.72,-1.84688328624424,5.33292226518915e-5,"Down",8.62136e-6,"TMEM143","GO:0016020//membrane;GO:0031224//intrinsic component of membrane;GO:0043231//intracellular membrane-bounded organelle","NA","NA","NA","gi|194387228|dbj|BAG59978.1|//unnamed protein product [Homo sapiens];gi|746816033|ref|NP_001290467.1|//transmembrane protein 143 isoform b [Homo sapiens] ;gi|746815995|ref|NP_001290468.1|//transmembrane protein 143 isoform c [Homo sapiens] ;gi|32171254|ref|NP_060743.2|//transmembrane protein 143 isoform a [Homo sapiens];gi|746815971|ref|NP_001290469.1|//transmembrane protein 143 isoform d [Homo sapiens]"]
[9829,5916,6.79,1.89,-1.84502534002366,5.4010911690205e-27,"Down",1.464714e-28,"DNAJC6","GO:0044444//cytoplasmic part","GO:0019904//protein domain specific binding;GO:0004721//phosphoprotein phosphatase activity","GO:0048193//Golgi vesicle transport","K09526//DnaJ homolog subfamily C member 6","gi|119626938|gb|EAX06533.1|//DnaJ (Hsp40) homolog, subfamily C, member 6, isoform CRA_a [Homo sapiens];gi|115344393|gb|AAI09280.2|//DNAJC6 protein [Homo sapiens];gi|767906888|ref|XP_011540787.1|//PREDICTED: putative tyrosine-protein phosphatase auxilin isoform X4 [Homo sapiens]"]
[2247,6774,36.76,10.25,-1.84251285689623,6.7904613e-167,"Down",1.6779e-169,"FGF2","GO:0043231//intracellular membrane-bounded organelle;GO:0044421//extracellular region part","GO:0070851//growth factor receptor binding;GO:0003713//transcription coactivator activity;GO:0005539//glycosaminoglycan binding;GO:0019838//growth factor binding;GO:0005262//calcium channel activity","GO:0043551//regulation of phosphatidylinositol 3-kinase activity;GO:0010595//positive regulation of endothelial cell migration;GO:0030323//respiratory tube development;GO:0003156//regulation of animal organ formation;GO:0017156//calcium ion regulated exocytosis;GO:0016049//cell growth;GO:0043067//regulation of programmed cell death;GO:0001932//regulation of protein phosphorylation;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007264//small GTPase mediated signal transduction;GO:0051283//negative regulation of sequestering of calcium ion;GO:0048468//cell development;GO:0048754//branching morphogenesis of an epithelial tube;GO:0009611//response to wounding;GO:0006694//steroid biosynthetic process;GO:0042221//response to chemical;GO:0010596//negative regulation of endothelial cell migration;GO:0007267//cell-cell signaling;GO:0021930//cerebellar granule cell precursor proliferation;GO:0046474//glycerophospholipid biosynthetic process;GO:0043647//inositol phosphate metabolic process;GO:0010518//positive regulation of phospholipase activity;GO:0045765//regulation of angiogenesis;GO:0001708//cell fate specification;GO:0043410//positive regulation of MAPK cascade;GO:0032412//regulation of ion transmembrane transporter activity;GO:0007049//cell cycle;GO:0002040//sprouting angiogenesis;GO:0030855//epithelial cell differentiation;GO:0008284//positive regulation of cell proliferation;GO:0045595//regulation of cell differentiation","K18497//fibroblast growth factor 2","gi|153285461|ref|NP_001997.5|//fibroblast growth factor 2 [Homo sapiens]"]
[8532,2259,4.69,1.31,-1.84002111097793,2.37682147508306e-7,"Down",2.65168e-8,"CPZ","GO:0031012//extracellular matrix","GO:0046914//transition metal ion binding;GO:0008235//metalloexopeptidase activity","GO:0019538//protein metabolic process;GO:0007166//cell surface receptor signaling pathway","K13022//carboxypeptidase Z [EC:3.4.17.-]","gi|62388877|ref|NP_001014447.1|//carboxypeptidase Z isoform 1 precursor [Homo sapiens];gi|62388875|ref|NP_003643.2|//carboxypeptidase Z isoform 2 precursor [Homo sapiens]"]
[57181,5855,17.63,4.95,-1.83253204435321,1.08900530285714e-60,"Down",1.130176e-62,"SLC39A10","GO:0031224//intrinsic component of membrane","GO:0008324//cation transmembrane transporter activity","GO:0000041//transition metal ion transport","K14716//solute carrier family 39 (zinc transporter), member 10","gi|694897857|ref|XP_009442180.1|//PREDICTED: zinc transporter ZIP10 [Pan troglodytes]"]
[81493,3413,6.33,1.78,-1.83032825846194,7.05749246511628e-15,"Down",3.56188e-16,"SYNC","NA","NA","NA","K10377//syncoilin 1","gi|239787821|ref|NP_001155180.1|//syncoilin isoform 2 [Homo sapiens];gi|166706887|ref|NP_110413.2|//syncoilin isoform 1 [Homo sapiens]"]
[103344718,3887,2.96,0.84,-1.81713594285019,4.51975668007313e-8,"Down",4.58174e-9,"HOTS","NA","NA","NA","K03006//DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6];K04443//mitogen-activated protein kinase-activated protein kinase 2 [EC:2.7.11.1];K13911//basic salivary proline-rich protein 1/2;K02184//formin 2","gi|645912866|ref|NP_001280100.1|//H19 opposite tumor suppressor [Homo sapiens]"]
[23089,6628,6.03,1.72,-1.80974943719799,2.53656182013423e-26,"Down",7.00422e-28,"PEG10","GO:0043231//intracellular membrane-bounded organelle","GO:0046914//transition metal ion binding;GO:0003676//nucleic acid binding","GO:0007179//transforming growth factor beta receptor signaling pathway;GO:0012501//programmed cell death;GO:0048869//cellular developmental process","K08103//heparan sulfate 6-O-sulfotransferase HS6ST3 [EC:2.8.2.-];K08327//phosducin;K11262//acetyl-CoA carboxylase / biotin carboxylase 1 [EC:6.4.1.2 6.3.4.14];K18438//cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10 [EC:3.1.4.17 3.1.4.35];K04612//calcium-sensing receptor","gi|289176996|ref|NP_001165908.1|//retrotransposon-derived protein PEG10 isoform 3 [Homo sapiens]"]
[89839,1045,5.7,1.65,-1.78849589480629,0.000172848288167539,"Down",3.05912e-5,"ARHGAP11B","GO:0044444//cytoplasmic part","GO:0008047//enzyme activator activity","GO:0035556//intracellular signal transduction;GO:0009966//regulation of signal transduction","K20635//Rho GTPase-activating protein 11","gi|397466530|ref|XP_003805006.1|//PREDICTED: rho GTPase-activating protein 11A isoform X1 [Pan paniscus]"]
[4091,4249,5.04,1.46,-1.7874553646199,9.83931090625e-16,"Down",4.66802e-17,"SMAD6","GO:0043231//intracellular membrane-bounded organelle;GO:0043234//protein complex;GO:0044444//cytoplasmic part","GO:0005072//transforming growth factor beta receptor, cytoplasmic mediator activity;GO:0070697//activin receptor binding;GO:0046332//SMAD binding;GO:0019899//enzyme binding;GO:0005160//transforming growth factor beta receptor binding;GO:0001071//nucleic acid binding transcription factor activity","GO:0000578//embryonic axis specification;GO:0010466//negative regulation of peptidase activity;GO:0006351//transcription, DNA-templated;GO:0030509//BMP signaling pathway;GO:0007183//SMAD protein complex assembly;GO:0006915//apoptotic process;GO:0007179//transforming growth factor beta receptor signaling pathway;GO:0001933//negative regulation of protein phosphorylation;GO:0002376//immune system process;GO:0034405//response to fluid shear stress","K04677//mothers against decapentaplegic homolog 6","gi|92859871|ref|NP_005576.3|//mothers against decapentaplegic homolog 6 [Homo sapiens];gi|1654327|gb|AAC50792.1|//Smad6 [Homo sapiens]"]
[5896,6582,0.79,0.23,-1.78021879212009,0.000703942798172403,"Down",0.0001427628,"RAG1","GO:0043231//intracellular membrane-bounded organelle","GO:0003677//DNA binding;GO:0042802//identical protein binding;GO:0019787//ubiquitin-like protein transferase activity;GO:0046914//transition metal ion binding;GO:0004518//nuclease activity","GO:0010466//negative regulation of peptidase activity;GO:0002329//pre-B cell differentiation;GO:0006325//chromatin organization;GO:0006513//protein monoubiquitination;GO:0002562//somatic diversification of immune receptors via germline recombination within a single locus;GO:0030217//T cell differentiation;GO:0070233//negative regulation of T cell apoptotic process","K10628//V(D)J recombination-activating protein 1 [EC:2.3.2.27]","gi|4557841|ref|NP_000439.1|//V(D)J recombination-activating protein 1 [Homo sapiens]"]
[154796,7558,1.3,0.38,-1.77444029958487,2.46387556363636e-6,"Down",3.18106e-7,"AMOT","GO:0031224//intrinsic component of membrane;GO:0031252//cell leading edge;GO:0009986//cell surface;GO:0043296//apical junction complex;GO:0032432//actin filament bundle","GO:0005515//protein binding;GO:0004871//signal transducer activity","GO:0007369//gastrulation;GO:0034329//cell junction assembly;GO:0030154//cell differentiation;GO:0001525//angiogenesis;GO:0008361//regulation of cell size;GO:0042221//response to chemical;GO:0010595//positive regulation of endothelial cell migration;GO:0043009//chordate embryonic development;GO:0043114//regulation of vascular permeability;GO:0001667//ameboidal-type cell migration;GO:0032233//positive regulation of actin filament bundle assembly","K16819//angiomotin","gi|166064029|ref|NP_001106962.1|//angiomotin isoform 1 [Homo sapiens]"]
[8863,6309,1.63,0.48,-1.76376565350992,1.03124892543554e-5,"Down",1.462656e-6,"PER3","GO:0043231//intracellular membrane-bounded organelle","GO:0060089//molecular transducer activity","GO:0006351//transcription, DNA-templated","K02633//period circadian protein","gi|530360697|ref|XP_005263581.1|//PREDICTED: period circadian protein homolog 3 isoform X6 [Homo sapiens];gi|767906630|ref|XP_011540687.1|//PREDICTED: period circadian protein homolog 3 isoform X4 [Homo sapiens];gi|767906640|ref|XP_011540691.1|//PREDICTED: period circadian protein homolog 3 isoform X10 [Homo sapiens];gi|767906643|ref|XP_011540692.1|//PREDICTED: period circadian protein homolog 3 isoform X12 [Homo sapiens];gi|530360695|ref|XP_005263580.1|//PREDICTED: period circadian protein homolog 3 isoform X5 [Homo sapiens];gi|577861068|ref|NP_001276792.1|//period circadian protein homolog 3 isoform 3 [Homo sapiens];gi|577861066|ref|NP_001276791.1|//period circadian protein homolog 3 isoform 1 [Homo sapiens];gi|8567388|ref|NP_058515.1|//period circadian protein homolog 3 isoform 4 [Homo sapiens];gi|530360693|ref|XP_005263579.1|//PREDICTED: period circadian protein homolog 3 isoform X3 [Homo sapiens];gi|577861064|ref|NP_001276790.1|//period circadian protein homolog 3 isoform 2 [Homo sapiens];gi|767906638|ref|XP_011540690.1|//PREDICTED: period circadian protein homolog 3 isoform X9 [Homo sapiens]"]
[115701,6195,2.48,0.74,-1.74474294475793,6.89561188235294e-11,"Down",4.92422e-12,"ALPK2","NA","GO:0032559//adenyl ribonucleotide binding;GO:0004672//protein kinase activity","GO:0006464//cellular protein modification process","K08868//alpha-kinase","gi|767998169|ref|XP_011524103.1|//PREDICTED: alpha-protein kinase 2 isoform X1 [Homo sapiens];gi|148596992|ref|NP_443179.3|//alpha-protein kinase 2 [Homo sapiens]"]
[8908,3237,9.46,2.84,-1.73594925383471,3.25139683137255e-19,"Down",1.229216e-20,"GYG2","GO:0044444//cytoplasmic part","GO:0035251//UDP-glucosyltransferase activity","GO:0005977//glycogen metabolic process;GO:0019318//hexose metabolic process","K00750//glycogenin [EC:2.4.1.186]","gi|694984015|ref|XP_009437004.1|//PREDICTED: glycogenin-2 isoform X6 [Pan troglodytes];gi|578837980|ref|XP_006724584.1|//PREDICTED: glycogenin-2 isoform X2 [Homo sapiens];gi|296040445|ref|NP_001171632.1|//glycogenin-2 isoform d [Homo sapiens];gi|2618766|gb|AAB84377.1|//glycogenin-2 alpha [Homo sapiens];gi|119619112|gb|EAW98706.1|//glycogenin 2, isoform CRA_b [Homo sapiens];gi|119943093|ref|NP_001073324.1|//glycogenin-2 isoform a [Homo sapiens];gi|2618768|gb|AAB84378.1|//glycogenin-2 beta [Homo sapiens]"]
[389856,2699,2.69,0.81,-1.731612359672,4.724481561051e-5,"Down",7.5531e-6,"USP27X","NA","NA","NA","K11366//ubiquitin carboxyl-terminal hydrolase 22/27/51 [EC:3.4.19.12]","gi|982320770|ref|XP_005593631.2|//PREDICTED: ubiquitin carboxyl-terminal hydrolase 27 [Macaca fascicularis]"]
[540,6403,5.77,1.74,-1.72948401279675,2.20726701511879e-25,"Down",6.3131e-27,"ATP7B","GO:0012505//endomembrane system;GO:0005768//endosome;GO:0044459//plasma membrane part;GO:0031410//cytoplasmic vesicle;GO:0016021//integral component of membrane;GO:0044431//Golgi apparatus part","GO:0032559//adenyl ribonucleotide binding;GO:0043682//copper-transporting ATPase activity;GO:0046914//transition metal ion binding","GO:0035434//copper ion transmembrane transport;GO:0009206//purine ribonucleoside triphosphate biosynthetic process;GO:0010038//response to metal ion;GO:0006874//cellular calcium ion homeostasis","K17686//Cu+-exporting ATPase [EC:3.6.3.54]","gi|530402454|ref|XP_005266489.1|//PREDICTED: copper-transporting ATPase 2 isoform X9 [Homo sapiens];gi|795098298|ref|XP_011794363.1|//PREDICTED: copper-transporting ATPase 2 isoform X6 [Colobus angolensis palliatus];gi|530402446|ref|XP_005266485.1|//PREDICTED: copper-transporting ATPase 2 isoform X7 [Homo sapiens];gi|530402452|ref|XP_005266488.1|//PREDICTED: copper-transporting ATPase 2 isoform X2 [Homo sapiens];gi|55743071|ref|NP_000044.2|//copper-transporting ATPase 2 isoform a [Homo sapiens];gi|795098265|ref|XP_011794322.1|//PREDICTED: copper-transporting ATPase 2 isoform X1 [Colobus angolensis palliatus];gi|795098291|ref|XP_011794355.1|//PREDICTED: copper-transporting ATPase 2 isoform X5 [Colobus angolensis palliatus];gi|767977783|ref|XP_011533421.1|//PREDICTED: copper-transporting ATPase 2 isoform X5 [Homo sapiens];gi|795398116|ref|XP_011754959.1|//PREDICTED: copper-transporting ATPase 2 isoform X2 [Macaca nemestrina];gi|795098283|ref|XP_011794349.1|//PREDICTED: copper-transporting ATPase 2 isoform X4 [Colobus angolensis palliatus]"]
[830,2373,41.44,12.53,-1.72563758836469,9.69492769942197e-60,"Down",1.03609e-61,"CAPZA2","GO:0015629//actin cytoskeleton;GO:0044444//cytoplasmic part","GO:0008092//cytoskeletal protein binding","GO:0006952//defense response;GO:0030835//negative regulation of actin filament depolymerization;GO:0065003//macromolecular complex assembly;GO:0007599//hemostasis","K10364//capping protein (actin filament) muscle Z-line, alpha","gi|426227627|ref|XP_004007919.1|//PREDICTED: F-actin-capping protein subunit alpha-2 isoform X1 [Ovis aries]"]
[400954,6060,1.28,0.39,-1.71459778113775,5.34957792366412e-5,"Down",8.6582e-6,"EML6","GO:0005856//cytoskeleton;GO:0015630//microtubule cytoskeleton","NA","NA","K18598//echinoderm microtubule-associated protein-like 6","gi|694894239|ref|XP_009440744.1|//PREDICTED: echinoderm microtubule-associated protein-like 6 [Pan troglodytes];gi|223005862|ref|NP_001034842.2|//echinoderm microtubule-associated protein-like 6 [Homo sapiens];gi|635080692|ref|XP_007968804.1|//PREDICTED: echinoderm microtubule-associated protein-like 6 isoform X5 [Chlorocebus sabaeus]"]
[114800,3857,12.58,3.84,-1.71195370615813,3.55003273994638e-30,"Down",8.1799e-32,"CCDC85A","NA","NA","NA","K16758//coiled-coil domain-containing protein 85B","gi|530367198|ref|XP_005264182.1|//PREDICTED: coiled-coil domain-containing protein 85A isoform X1 [Homo sapiens];gi|426335623|ref|XP_004029315.1|//PREDICTED: coiled-coil domain-containing protein 85A, partial [Gorilla gorilla gorilla]"]
[64753,2912,1.76,0.54,-1.70454411647383,6.67353803236733e-5,"Down",1.095354e-5,"CCDC136","GO:0016020//membrane","GO:0005488//binding","NA","NA","gi|694924005|ref|XP_519361.4|//PREDICTED: coiled-coil domain-containing protein 136 isoform X1 [Pan troglodytes];gi|767948502|ref|XP_011514791.1|//PREDICTED: coiled-coil domain-containing protein 136 isoform X8 [Homo sapiens];gi|530386303|ref|XP_005250591.1|//PREDICTED: coiled-coil domain-containing protein 136 isoform X5 [Homo sapiens];gi|767948489|ref|XP_011514785.1|//PREDICTED: coiled-coil domain-containing protein 136 isoform X1 [Homo sapiens];gi|767948498|ref|XP_011514789.1|//PREDICTED: coiled-coil domain-containing protein 136 isoform X6 [Homo sapiens];gi|332868791|ref|XP_003318819.1|//PREDICTED: coiled-coil domain-containing protein 136 isoform X10 [Pan troglodytes];gi|767948493|ref|XP_011514787.1|//PREDICTED: coiled-coil domain-containing protein 136 isoform X3 [Homo sapiens];gi|767948504|ref|XP_011514792.1|//PREDICTED: coiled-coil domain-containing protein 136 isoform X10 [Homo sapiens];gi|530386311|ref|XP_005250595.1|//PREDICTED: coiled-coil domain-containing protein 136 isoform X9 [Homo sapiens];gi|767948500|ref|XP_011514790.1|//PREDICTED: coiled-coil domain-containing protein 136 isoform X7 [Homo sapiens];gi|767948491|ref|XP_011514786.1|//PREDICTED: coiled-coil domain-containing protein 136 isoform X2 [Homo sapiens];gi|767948495|ref|XP_011514788.1|//PREDICTED: coiled-coil domain-containing protein 136 isoform X4 [Homo sapiens]"]
[4616,1393,18.32,5.65,-1.69709673079439,1.07714238132296e-15,"Down",5.1302e-17,"GADD45B","NA","NA","GO:0000165//MAPK cascade;GO:0012501//programmed cell death;GO:0032501//multicellular organismal process;GO:0007049//cell cycle;GO:0033673//negative regulation of kinase activity;GO:0048869//cellular developmental process","K04402//growth arrest and DNA-damage-inducible protein","gi|795331304|ref|XP_011819451.1|//PREDICTED: growth arrest and DNA damage-inducible protein GADD45 beta isoform X1 [Colobus angolensis palliatus];gi|795331310|ref|XP_011819452.1|//PREDICTED: growth arrest and DNA damage-inducible protein GADD45 beta isoform X2 [Colobus angolensis palliatus]"]
[1756,6454,4.72,1.46,-1.69281849048182,1.83473425327511e-17,"Down",7.7864e-19,"DMD","GO:0016323//basolateral plasma membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0044463//cell projection part;GO:0043234//protein complex;GO:0031674//I band;GO:0030016//myofibril;GO:0005886//plasma membrane","GO:0019904//protein domain specific binding;GO:0008092//cytoskeletal protein binding;GO:0046914//transition metal ion binding;GO:0001948//glycoprotein binding;GO:0005102//receptor binding;GO:0005198//structural molecule activity;GO:0019899//enzyme binding","GO:0014706//striated muscle tissue development;GO:0048513//animal organ development;GO:0006518//peptide metabolic process;GO:0006936//muscle contraction;GO:0043112//receptor metabolic process;GO:0006351//transcription, DNA-templated;GO:0021604//cranial nerve structural organization;GO:0019725//cellular homeostasis;GO:0048858//cell projection morphogenesis","K10366//dystrophin","gi|768032059|ref|XP_011543769.1|//PREDICTED: dystrophin isoform X5 [Homo sapiens];gi|5032297|ref|NP_004006.1|//dystrophin Dp71 isoform [Homo sapiens];gi|578837829|ref|XP_006724531.1|//PREDICTED: dystrophin isoform X1 [Homo sapiens];gi|578837832|ref|XP_006724532.1|//PREDICTED: dystrophin isoform X2 [Homo sapiens];gi|837811053|ref|XP_012783201.1|//PREDICTED: dystrophin [Ochotona princeps];gi|795394671|ref|XP_011754158.1|//PREDICTED: dystrophin isoform X13 [Macaca nemestrina];gi|5032287|ref|NP_004000.1|//dystrophin Dp427p1 isoform [Homo sapiens];gi|150036268|ref|NP_004002.2|//dystrophin Dp260-1 isoform [Homo sapiens];gi|578837844|ref|XP_006724538.1|//PREDICTED: dystrophin isoform X9 [Homo sapiens];gi|5032281|ref|NP_000100.2|//dystrophin Dp427c isoform [Homo sapiens];gi|768032081|ref|XP_011543771.1|//PREDICTED: dystrophin isoform X11 [Homo sapiens];gi|119619468|gb|EAW99062.1|//dystrophin (muscular dystrophy, Duchenne and Becker types), isoform CRA_b [Homo sapiens];gi|768032078|ref|XP_011543770.1|//PREDICTED: dystrophin isoform X10 [Homo sapiens];gi|5032301|ref|NP_004008.1|//dystrophin Dp71a isoform [Homo sapiens] ;gi|578837842|ref|XP_006724537.1|//PREDICTED: dystrophin isoform X8 [Homo sapiens];gi|5032299|ref|NP_004007.1|//dystrophin Dp71b isoform [Homo sapiens];gi|5032303|ref|NP_004009.1|//dystrophin Dp71ab isoform [Homo sapiens];gi|5032291|ref|NP_004003.1|//dystrophin Dp260-2 isoform [Homo sapiens];gi|578837840|ref|XP_006724536.1|//PREDICTED: dystrophin isoform X7 [Homo sapiens];gi|578837834|ref|XP_006724533.1|//PREDICTED: dystrophin isoform X3 [Homo sapiens];gi|5032283|ref|NP_003997.1|//dystrophin Dp427m isoform [Homo sapiens]"]
[54494,1395,6.96,2.16,-1.68805599368526,1.90917309242298e-5,"Down",2.83286e-6,"C11orf71","NA","NA","NA","NA","gi|169790777|ref|NP_061894.2|//uncharacterized protein C11orf71 isoform 2 [Homo sapiens];gi|409104122|ref|NP_001258491.1|//uncharacterized protein C11orf71 isoform 1 [Homo sapiens]"]
[79412,2068,6.15,1.92,-1.67948009950545,3.19127369364882e-8,"Down",3.16604e-9,"KREMEN2","GO:0031224//intrinsic component of membrane","NA","GO:0007166//cell surface receptor signaling pathway","K01343//tissue plasminogen activator [EC:3.4.21.68];K08648//hyaluronan binding protein 2 [EC:3.4.21.-];K01315//plasminogen [EC:3.4.21.7]","gi|27437008|ref|NP_757384.1|//kremen protein 2 isoform d precursor [Homo sapiens];gi|359279863|ref|NP_001240654.1|//kremen protein 2 isoform e precursor [Homo sapiens];gi|359279865|ref|NP_001240655.1|//kremen protein 2 isoform f precursor [Homo sapiens] ;gi|13375642|ref|NP_078783.1|//kremen protein 2 isoform b precursor [Homo sapiens]"]
[9760,4016,5.63,1.76,-1.67755949344293,5.68785176470588e-13,"Down",3.4047e-14,"TOX","GO:0043231//intracellular membrane-bounded organelle","GO:0003676//nucleic acid binding","NA","K18808//toll-like receptor 13","gi|675700445|ref|XP_008959442.1|//PREDICTED: thymocyte selection-associated high mobility group box protein TOX isoform X2 [Pan paniscus];gi|7662322|ref|NP_055544.1|//thymocyte selection-associated high mobility group box protein TOX [Homo sapiens]"]
[51523,2567,22.69,7.11,-1.67413514405292,9.50299961927711e-34,"Down",1.948972e-35,"CXXC5","GO:0043231//intracellular membrane-bounded organelle","GO:0060089//molecular transducer activity;GO:0046914//transition metal ion binding;GO:0003676//nucleic acid binding","GO:0007249//I-kappaB kinase/NF-kappaB signaling","K03344//Dvl-binding protein IDAX","gi|197102116|ref|NP_001126301.1|//CXXC-type zinc finger protein 5 [Pongo abelii]"]
[4247,2728,43.04,13.5,-1.67271867061843,1.95894270881119e-68,"Down",1.730472e-70,"MGAT2","GO:0031224//intrinsic component of membrane;GO:0012505//endomembrane system;GO:0044431//Golgi apparatus part","GO:0008375//acetylglucosaminyltransferase activity;GO:0030246//carbohydrate binding","GO:0009311//oligosaccharide metabolic process;GO:0006487//protein N-linked glycosylation","K00736//alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase [EC:2.4.1.143]","gi|194375650|dbj|BAG56770.1|//unnamed protein product [Homo sapiens]"]
[84929,3119,2.22,0.7,-1.66513284940514,6.67102729571106e-5,"Down",1.095354e-5,"FIBCD1","GO:0031224//intrinsic component of membrane;GO:0044421//extracellular region part","GO:0043169//cation binding;GO:0005515//protein binding;GO:0030247//polysaccharide binding","GO:0023052//signaling","K10104//ficolin","gi|223029461|ref|NP_001138578.1|//fibrinogen C domain-containing protein 1 [Homo sapiens]"]
[80237,2127,2.78,0.88,-1.65950945408621,0.000597758338976744,"Down",0.0001190864,"ELL3","GO:0043231//intracellular membrane-bounded organelle;GO:0043234//protein complex","NA","GO:0006354//DNA-templated transcription, elongation;GO:0048232//male gamete generation","K15183//RNA polymerase II elongation factor ELL","gi|119597643|gb|EAW77237.1|//elongation factor RNA polymerase II-like 3, isoform CRA_a [Homo sapiens]"]
[54414,4074,3.46,1.1,-1.65326851411206,4.28715359250586e-5,"Down",6.78508e-6,"SIAE","GO:0000323//lytic vacuole","GO:0008126//acetylesterase activity","NA","K05970//sialate O-acetylesterase [EC:3.1.1.53]","gi|635018794|ref|XP_008019528.1|//PREDICTED: sialate O-acetylesterase isoform X1 [Chlorocebus sabaeus];gi|321267600|ref|NP_001186851.1|//sialate O-acetylesterase isoform 2 [Homo sapiens];gi|24850115|ref|NP_733746.1|//sialate O-acetylesterase isoform 1 precursor [Homo sapiens]"]
[51714,3498,35.51,11.38,-1.64172480271439,1.15401534306569e-70,"Down",9.7665e-73,"SELENOT","NA","GO:0005488//binding","GO:0019725//cellular homeostasis;GO:0006451//translational readthrough","NA","gi|744541945|ref|XP_010985141.1|//PREDICTED: LOW QUALITY PROTEIN: selenoprotein T [Camelus dromedarius]"]
[54507,4108,4.93,1.58,-1.64166308820081,3.89861927147766e-14,"Down",2.10248e-15,"ADAMTSL4","GO:0031012//extracellular matrix;GO:0005576//extracellular region;GO:0005578//proteinaceous extracellular matrix","GO:0004175//endopeptidase activity;GO:0008233//peptidase activity;GO:0019899//enzyme binding","GO:0043062//extracellular structure organization;GO:0006915//apoptotic process","K08630//a disintegrin and metalloproteinase with thrombospondin motifs 16 [EC:3.4.24.-];K08625//a disintegrin and metalloproteinase with thrombospondin motifs 10 [EC:3.4.24.-];K08621//a disintegrin and metalloproteinase with thrombospondin motifs 6 [EC:3.4.24.-];K08624//a disintegrin and metalloproteinase with thrombospondin motifs 9 [EC:3.4.24.-];K08632//a disintegrin and metalloproteinase with thrombospondin motifs 18 [EC:3.4.24.-]","gi|767909587|ref|XP_011507953.1|//PREDICTED: ADAMTS-like protein 4 isoform X6 [Homo sapiens];gi|568384851|ref|NP_001275536.1|//ADAMTS-like protein 4 isoform 3 precursor [Homo sapiens];gi|767909582|ref|XP_011507951.1|//PREDICTED: ADAMTS-like protein 4 isoform X4 [Homo sapiens];gi|767909572|ref|XP_011507946.1|//PREDICTED: ADAMTS-like protein 4 isoform X2 [Homo sapiens];gi|48734970|gb|AAH71852.1|//ADAMTSL4 protein, partial [Homo sapiens];gi|767909574|ref|XP_011507947.1|//PREDICTED: ADAMTS-like protein 4 isoform X3 [Homo sapiens];gi|767909584|ref|XP_011507952.1|//PREDICTED: ADAMTS-like protein 4 isoform X5 [Homo sapiens]"]
[5587,4443,5.16,1.66,-1.63618782407633,1.69721727153285e-11,"Down",1.149092e-12,"PRKD1","GO:0016021//integral component of membrane;GO:0044444//cytoplasmic part","GO:0043169//cation binding;GO:0004674//protein serine/threonine kinase activity;GO:0032559//adenyl ribonucleotide binding","GO:0007165//signal transduction;GO:0006464//cellular protein modification process;GO:0006643//membrane lipid metabolic process","K06070//protein kinase D [EC:2.7.11.13]","gi|115529463|ref|NP_002733.2|//serine/threonine-protein kinase D1 [Homo sapiens];gi|767981031|ref|XP_011535266.1|//PREDICTED: serine/threonine-protein kinase D1 isoform X2 [Homo sapiens];gi|530404191|ref|XP_005267916.1|//PREDICTED: serine/threonine-protein kinase D1 isoform X1 [Homo sapiens]"]
[90525,2094,5.05,1.63,-1.63141142340808,5.12338441162228e-8,"Down",5.22846e-9,"SHF","NA","NA","NA","K19862//NCK adaptor protein 2;K04364//growth factor receptor-binding protein 2;K07365//NCK adaptor protein 1","gi|829775918|ref|XP_012622163.1|//PREDICTED: SH2 domain-containing adapter protein F isoform X1 [Microcebus murinus];gi|795266944|ref|XP_011920595.1|//PREDICTED: LOW QUALITY PROTEIN: SH2 domain-containing adapter protein F [Cercocebus atys];gi|767985695|ref|XP_011520480.1|//PREDICTED: SH2 domain-containing adapter protein F isoform X5 [Homo sapiens];gi|667667680|ref|NP_001288097.1|//SH2 domain-containing adapter protein F isoform a [Homo sapiens];gi|767985687|ref|XP_006720805.2|//PREDICTED: SH2 domain-containing adapter protein F isoform X2 [Homo sapiens];gi|111074524|ref|NP_612365.2|//SH2 domain-containing adapter protein F isoform b [Homo sapiens] ;gi|767985685|ref|XP_011520476.1|//PREDICTED: SH2 domain-containing adapter protein F isoform X1 [Homo sapiens];gi|667667713|ref|NP_001288099.1|//SH2 domain-containing adapter protein F isoform d [Homo sapiens];gi|767985691|ref|XP_011520478.1|//PREDICTED: SH2 domain-containing adapter protein F isoform X3 [Homo sapiens]"]
[221,2833,22.67,7.35,-1.62496823601706,5.85120283862069e-37,"Down",1.048214e-38,"ALDH3B1","NA","GO:0016620//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor","GO:0044238//primary metabolic process;GO:0044237//cellular metabolic process;GO:0044281//small molecule metabolic process","K00129//aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]","gi|4502043|ref|NP_000685.1|//aldehyde dehydrogenase family 3 member B1 isoform a [Homo sapiens];gi|586946392|ref|NP_001276987.1|//aldehyde dehydrogenase family 3 member B1 isoform c [Homo sapiens];gi|71773324|ref|NP_001025181.1|//aldehyde dehydrogenase family 3 member B1 isoform b [Homo sapiens];gi|795170190|ref|XP_011842427.1|//PREDICTED: aldehyde dehydrogenase family 3 member B1 isoform X1 [Mandrillus leucophaeus];gi|694945612|ref|XP_009421851.1|//PREDICTED: LOW QUALITY PROTEIN: aldehyde dehydrogenase family 3 member B1 [Pan troglodytes]"]
[388722,697,10.67,3.48,-1.6164009649757,0.000142461298295455,"Down",2.4782e-5,"C1orf53","NA","NA","NA","K02874//large subunit ribosomal protein L14;K09373//LIM homeobox protein 2/9","gi|66912196|ref|NP_001019765.1|//uncharacterized protein C1orf53 [Homo sapiens]"]
[11346,4889,1.47,0.48,-1.61470984411521,0.000310883694328358,"Down",5.79018e-5,"SYNPO","GO:0030425//dendrite;GO:0044430//cytoskeletal part;GO:0043296//apical junction complex;GO:0043025//neuronal cell body","GO:0008092//cytoskeletal protein binding","GO:0032231//regulation of actin filament bundle assembly","K21112//synaptopodin","gi|261278297|ref|NP_001159680.1|//synaptopodin isoform C [Homo sapiens];gi|578810794|ref|XP_006714818.1|//PREDICTED: synaptopodin isoform X3 [Homo sapiens]"]
[147906,2946,1.68,0.55,-1.6109577092541,0.000629603087719298,"Down",0.000126364,"DACT3","NA","NA","NA","NA","gi|182507165|ref|NP_659493.2|//dapper homolog 3 isoform 1 [Homo sapiens]"]
[55701,5157,9.64,3.16,-1.60910858805286,2.95628414634146e-28,"Down",7.4875e-30,"ARHGEF40","GO:0044424//intracellular part;GO:0005622//intracellular","GO:0005088//Ras guanyl-nucleotide exchange factor activity;GO:0005085//guanyl-nucleotide exchange factor activity","GO:0007266//Rho protein signal transduction","K20685//guanine nucleotide exchange factor MCF2;K18655//ATP-dependent RNA helicase DDX19/DBP5 [EC:3.6.4.13]","gi|767980972|ref|XP_011535240.1|//PREDICTED: rho guanine nucleotide exchange factor 40 isoform X3 [Homo sapiens];gi|50843837|ref|NP_060541.3|//rho guanine nucleotide exchange factor 40 isoform 1 [Homo sapiens];gi|767980970|ref|XP_011535239.1|//PREDICTED: rho guanine nucleotide exchange factor 40 isoform X2 [Homo sapiens];gi|530404161|ref|XP_005267901.1|//PREDICTED: rho guanine nucleotide exchange factor 40 isoform X1 [Homo sapiens]"]
[3795,2206,4.68,1.54,-1.6035781788885,6.36134663900415e-7,"Down",7.5764e-8,"KHK","GO:0044444//cytoplasmic part","GO:0032559//adenyl ribonucleotide binding;GO:0016773//phosphotransferase activity, alcohol group as acceptor","GO:0009746//response to hexose;GO:0006000//fructose metabolic process;GO:0043434//response to peptide hormone;GO:0034285//response to disaccharide;GO:0010038//response to metal ion","K00846//ketohexokinase [EC:2.7.1.3]","gi|578802877|ref|XP_006712071.1|//PREDICTED: ketohexokinase isoform X1 [Homo sapiens];gi|635081887|ref|XP_007969368.1|//PREDICTED: ketohexokinase isoform X3 [Chlorocebus sabaeus];gi|578802889|ref|XP_006712076.1|//PREDICTED: ketohexokinase isoform X8 [Homo sapiens];gi|530367549|ref|XP_005264353.1|//PREDICTED: ketohexokinase isoform X7 [Homo sapiens];gi|578802884|ref|XP_006712074.1|//PREDICTED: ketohexokinase isoform X5 [Homo sapiens];gi|578802879|ref|XP_006712072.1|//PREDICTED: ketohexokinase isoform X2 [Homo sapiens];gi|578802882|ref|XP_006712073.1|//PREDICTED: ketohexokinase isoform X4 [Homo sapiens];gi|4557693|ref|NP_000212.1|//ketohexokinase isoform a [Homo sapiens];gi|119621045|gb|EAX00640.1|//ketohexokinase (fructokinase), isoform CRA_a [Homo sapiens];gi|675786385|ref|XP_008950694.1|//PREDICTED: ketohexokinase isoform X2 [Pan paniscus];gi|578802891|ref|XP_006712077.1|//PREDICTED: ketohexokinase isoform X9 [Homo sapiens];gi|530367545|ref|XP_005264351.1|//PREDICTED: ketohexokinase isoform X3 [Homo sapiens];gi|578802886|ref|XP_006712075.1|//PREDICTED: ketohexokinase isoform X6 [Homo sapiens];gi|5670342|ref|NP_006479.1|//ketohexokinase isoform b [Homo sapiens]"]
[375035,880,20.33,6.72,-1.59707707706597,6.08343287238979e-10,"Down",4.85908e-11,"SFT2D2","GO:0031224//intrinsic component of membrane","NA","GO:0006810//transport","K10184//T-box protein 19","gi|40786408|ref|NP_955376.1|//vesicle transport protein SFT2B [Homo sapiens]"]
[729852,2378,7.62,2.52,-1.59636726399341,3.59032665083135e-10,"Down",2.8012e-11,"UMAD1","NA","NA","NA","NA","gi|696221366|ref|NP_001289277.1|//UBAP1-MVB12-associated (UMA)-domain containing protein 1 isoform a [Homo sapiens]"]
[148327,1690,8.78,2.91,-1.59320178662707,8.30776556521739e-10,"Down",6.72812e-11,"CREB3L4","GO:0012505//endomembrane system;GO:0043231//intracellular membrane-bounded organelle;GO:0031224//intrinsic component of membrane;GO:0031090//organelle membrane","GO:0003677//DNA binding;GO:0005515//protein binding;GO:0001071//nucleic acid binding transcription factor activity","GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0006950//response to stress;GO:0048232//male gamete generation","K09048//cyclic AMP-responsive element-binding protein 3","gi|28190375|gb|AAO33070.1|AF468007_1//CREB3 [Homo sapiens];gi|18702325|ref|NP_570968.1|//cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 1 [Homo sapiens];gi|364023829|ref|NP_001242909.1|//cyclic AMP-responsive element-binding protein 3-like protein 4 isoform 2 [Homo sapiens]"]
[1659,4236,18.89,6.29,-1.58649077950908,1.04496413194805e-43,"Down",1.491146e-45,"DHX8","GO:0005681//spliceosomal complex","GO:0032559//adenyl ribonucleotide binding;GO:0003724//RNA helicase activity;GO:0042623//ATPase activity, coupled;GO:0003676//nucleic acid binding","GO:0006396//RNA processing;GO:0000377//RNA splicing, via transesterification reactions with bulged adenosine as nucleophile;GO:0009207//purine ribonucleoside triphosphate catabolic process","K12818//ATP-dependent RNA helicase DHX8/PRP22 [EC:3.6.4.13]","gi|119572065|gb|EAW51680.1|//DEAH (Asp-Glu-Ala-His) box polypeptide 8, isoform CRA_e [Homo sapiens];gi|686753670|ref|XP_009249963.1|//PREDICTED: ATP-dependent RNA helicase DHX8 isoform X3 [Pongo abelii];gi|119572061|gb|EAW51676.1|//DEAH (Asp-Glu-Ala-His) box polypeptide 8, isoform CRA_a [Homo sapiens];gi|686753672|ref|XP_009249964.1|//PREDICTED: ATP-dependent RNA helicase DHX8 isoform X4 [Pongo abelii];gi|701165628|ref|NP_001289552.1|//ATP-dependent RNA helicase DHX8 isoform 2 [Homo sapiens] ;gi|768962523|ref|XP_011619256.1|//PREDICTED: ATP-dependent RNA helicase DHX8-like, partial [Takifugu rubripes]"]
[2065,1708,5.37,1.79,-1.58496250072116,6.0113969375e-7,"Down",7.1299e-8,"ERBB3","GO:0043231//intracellular membrane-bounded organelle;GO:0044421//extracellular region part;GO:0044459//plasma membrane part;GO:0043234//protein complex;GO:0016021//integral component of membrane","GO:0004713//protein tyrosine kinase activity;GO:0004872//receptor activity;GO:0032559//adenyl ribonucleotide binding;GO:0042802//identical protein binding;GO:0030295//protein kinase activator activity;GO:0046983//protein dimerization activity","GO:0014706//striated muscle tissue development;GO:0048771//tissue remodeling;GO:0035556//intracellular signal transduction;GO:0010828//positive regulation of glucose transport;GO:0051046//regulation of secretion;GO:0008283//cell proliferation;GO:0045860//positive regulation of protein kinase activity;GO:0009611//response to wounding;GO:0032868//response to insulin;GO:0043066//negative regulation of apoptotic process;GO:0048667//cell morphogenesis involved in neuron differentiation;GO:0048511//rhythmic process;GO:0007155//cell adhesion;GO:0021675//nerve development;GO:0009887//animal organ morphogenesis;GO:0009967//positive regulation of signal transduction;GO:0007423//sensory organ development;GO:0007422//peripheral nervous system development;GO:0007167//enzyme linked receptor protein signaling pathway","K05084//receptor tyrosine-protein kinase erbB-3 [EC:2.7.10.1]","gi|54792100|ref|NP_001973.2|//receptor tyrosine-protein kinase erbB-3 isoform 1 precursor [Homo sapiens];gi|54792102|ref|NP_001005915.1|//receptor tyrosine-protein kinase erbB-3 isoform s precursor [Homo sapiens]"]
[121274,5099,10.74,3.58,-1.58496250072116,1.00152707394958e-24,"Down",2.94494e-26,"ZNF641","GO:0031981//nuclear lumen","GO:0046914//transition metal ion binding;GO:0003676//nucleic acid binding","GO:0006351//transcription, DNA-templated","K09228//KRAB domain-containing zinc finger protein","gi|530399742|ref|XP_005268694.1|//PREDICTED: zinc finger protein 641 isoform X3 [Homo sapiens];gi|635064952|ref|XP_008001243.1|//PREDICTED: zinc finger protein 641 isoform X1 [Chlorocebus sabaeus];gi|56718738|gb|AAW28082.1|//zinc finger protein 641 [Homo sapiens];gi|289547731|ref|NP_689533.2|//zinc finger protein 641 isoform 1 [Homo sapiens]"]
[7351,1646,6.86,2.29,-1.58286097807587,1.3451968992e-6,"Down",1.661968e-7,"UCP2","NA","NA","NA","K15103//solute carrier family 25 (mitochondrial uncoupling protein), member 8/9","gi|13259541|ref|NP_003346.2|//mitochondrial uncoupling protein 2 [Homo sapiens]"]
[3007,777,378.57,126.4,-1.58256362484808,7.53639698181818e-153,"Down",2.04844e-155,"HIST1H1D","GO:0043231//intracellular membrane-bounded organelle;GO:0000785//chromatin","GO:0003676//nucleic acid binding","GO:0034728//nucleosome organization","K11275//histone H1/5","gi|926722098|ref|XP_013829520.1|//PREDICTED: histone H1.3 [Capra hircus]"]
[11149,5599,3.14,1.05,-1.5803752312255,1.09447979012987e-5,"Down",1.561804e-6,"BVES","GO:0031224//intrinsic component of membrane;GO:0043296//apical junction complex","NA","GO:0001881//receptor recycling;GO:0006810//transport;GO:0048513//animal organ development;GO:0016337//single organismal cell-cell adhesion;GO:0065008//regulation of biological quality;GO:0040011//locomotion;GO:0000904//cell morphogenesis involved in differentiation","K21108//blood vessel epicardial substance","gi|22202606|ref|NP_671488.1|//blood vessel epicardial substance [Homo sapiens];gi|795237383|ref|XP_011808261.1|//PREDICTED: blood vessel epicardial substance isoform X1 [Colobus angolensis palliatus]"]
[874,1110,21.75,7.29,-1.57702468129652,1.99435122307692e-13,"Down",1.153146e-14,"CBR3","GO:0031981//nuclear lumen;GO:0044444//cytoplasmic part","GO:0050661//NADP binding;GO:0016616//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor","GO:0042374//phylloquinone metabolic process","K00084//carbonyl reductase 3 [EC:1.1.1.184]","gi|768021838|ref|XP_011528074.1|//PREDICTED: carbonyl reductase [NADPH] 3 isoform X1 [Homo sapiens];gi|4502601|ref|NP_001227.1|//carbonyl reductase [NADPH] 3 [Homo sapiens]"]
[79411,2341,5.16,1.73,-1.57659902778653,9.92102581924198e-8,"Down",1.05106e-8,"GLB1L","NA","GO:0043167//ion binding;GO:0016798//hydrolase activity, acting on glycosyl bonds","GO:0044238//primary metabolic process","K12309//beta-galactosidase [EC:3.2.1.23]","gi|40255043|ref|NP_078782.3|//beta-galactosidase-1-like protein isoform 1 precursor [Homo sapiens];gi|556695395|ref|NP_001273356.1|//beta-galactosidase-1-like protein isoform 2 precursor [Homo sapiens]"]
[64759,7708,7.51,2.52,-1.57538917401436,1.63158324130435e-30,"Down",3.70906e-32,"TNS3","GO:0005924//cell-substrate adherens junction","GO:0005488//binding","GO:0008283//cell proliferation;GO:0048870//cell motility;GO:0048856//anatomical structure development","K18080//tensin","gi|65288071|ref|NP_073585.8|//tensin-3 [Homo sapiens];gi|767945698|ref|XP_011513779.1|//PREDICTED: tensin-3 isoform X3 [Homo sapiens];gi|767945700|ref|XP_011513780.1|//PREDICTED: tensin-3 isoform X4 [Homo sapiens];gi|119581416|gb|EAW61012.1|//tensin 3, isoform CRA_b, partial [Homo sapiens];gi|767945696|ref|XP_011513778.1|//PREDICTED: tensin-3 isoform X2 [Homo sapiens];gi|767945702|ref|XP_011513781.1|//PREDICTED: tensin-3 isoform X5 [Homo sapiens]"]
[8508,2083,67.87,22.81,-1.57310756647458,2.55295730380165e-74,"Down",1.908252e-76,"NIPSNAP1","GO:0043231//intracellular membrane-bounded organelle;GO:0019866//organelle inner membrane","NA","NA","K13174//THO complex subunit 5;K19269//phosphoglycolate phosphatase [EC:3.1.3.18 3.1.3.48]","gi|321267511|ref|NP_001189431.1|//protein NipSnap homolog 1 isoform 2 [Homo sapiens];gi|332859539|ref|XP_515060.3|//PREDICTED: protein NipSnap homolog 1 isoform X1 [Pan troglodytes]"]
[1164,632,242.34,81.53,-1.57162963174507,5.95370877798165e-78,"Down",4.00886e-80,"CKS2","NA","GO:0019887//protein kinase regulator activity;GO:0016772//transferase activity, transferring phosphorus-containing groups","GO:0048017//inositol lipid-mediated signaling;GO:0016310//phosphorylation;GO:0000226//microtubule cytoskeleton organization;GO:0019222//regulation of metabolic process;GO:0007126//meiotic nuclear division;GO:0051726//regulation of cell cycle","K02219//cyclin-dependent kinase regulatory subunit CKS1","gi|830036530|ref|XP_004684547.2|//PREDICTED: cyclin-dependent kinases regulatory subunit 2 [Condylura cristata]"]
[9649,2833,2.11,0.71,-1.5713520692025,4.79809570976457e-5,"Down",7.67968e-6,"RALGPS1","GO:0016020//membrane;GO:0044424//intracellular part","GO:0030695//GTPase regulator activity","GO:0035556//intracellular signal transduction","K04349//Ras-specific guanine nucleotide-releasing factor 1;K17639//ral guanine nucleotide dissociation stimulator-like 3;K17635//ral guanine nucleotide dissociation stimulator-like 1;K03099//son of sevenless","gi|635071093|ref|XP_008004381.1|//PREDICTED: ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X8 [Chlorocebus sabaeus];gi|635071095|ref|XP_008004382.1|//PREDICTED: ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X9 [Chlorocebus sabaeus];gi|675777294|ref|XP_008975976.1|//PREDICTED: ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X2 [Pan paniscus];gi|767958818|ref|XP_011517536.1|//PREDICTED: ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X9 [Homo sapiens];gi|635071085|ref|XP_008004377.1|//PREDICTED: ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X4 [Chlorocebus sabaeus];gi|635071097|ref|XP_008004383.1|//PREDICTED: ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X10 [Chlorocebus sabaeus];gi|635071112|ref|XP_008004391.1|//PREDICTED: ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X16 [Chlorocebus sabaeus];gi|21708078|gb|AAH33708.1|//RALGPS1 protein [Homo sapiens];gi|675777291|ref|XP_008975975.1|//PREDICTED: ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X1 [Pan paniscus];gi|635071114|ref|XP_008004392.1|//PREDICTED: ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X17 [Chlorocebus sabaeus];gi|767958806|ref|XP_011517531.1|//PREDICTED: ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X5 [Homo sapiens];gi|675777303|ref|XP_003824055.2|//PREDICTED: ras-specific guanine nucleotide-releasing factor RalGPS1 isoform X4 [Pan paniscus]"]
[26225,3169,16.13,5.43,-1.57072233535128,1.7003784e-27,"Down",4.47468e-29,"ARL5A","GO:0044464//cell part","GO:0032561//guanyl ribonucleotide binding","GO:0035556//intracellular signal transduction","K07949//ADP-ribosylation factor-like protein 5A","gi|71042331|pdb|1ZJ6|A//Chain A, Crystal Structure Of Human Arl5;gi|984087617|ref|XP_015334662.1|//PREDICTED: ADP-ribosylation factor-like protein 5A [Marmota marmota marmota]"]
[1363,2648,2.79,0.94,-1.56953246015155,0.000151487041522735,"Down",2.65486e-5,"CPE","GO:0016020//membrane;GO:0044421//extracellular region part","GO:0046914//transition metal ion binding;GO:0008235//metalloexopeptidase activity","GO:0007186//G-protein coupled receptor signaling pathway;GO:0016486//peptide hormone processing;GO:0043412//macromolecule modification;GO:0044237//cellular metabolic process;GO:0003208//cardiac ventricle morphogenesis","K01294//carboxypeptidase E [EC:3.4.17.10]","gi|4503009|ref|NP_001864.1|//carboxypeptidase E preproprotein [Homo sapiens]"]
[9127,2740,5.55,1.87,-1.56944950134983,2.27442585451587e-10,"Down",1.726754e-11,"P2RX6","GO:0030425//dendrite;GO:0044297//cell body;GO:0044459//plasma membrane part;GO:0044430//cytoskeletal part;GO:0016021//integral component of membrane","GO:0005515//protein binding;GO:0005231//excitatory extracellular ligand-gated ion channel activity;GO:0016502//nucleotide receptor activity;GO:0032559//adenyl ribonucleotide binding","GO:0035587//purinergic receptor signaling pathway;GO:0003012//muscle system process;GO:0006811//ion transport;GO:0051259//protein oligomerization","K05221//P2X purinoceptor 6","gi|768026349|ref|XP_011528802.1|//PREDICTED: P2X purinoceptor 6 isoform X3 [Homo sapiens];gi|768026338|ref|XP_011528800.1|//PREDICTED: P2X purinoceptor 6 isoform X1 [Homo sapiens];gi|768026346|ref|XP_011528801.1|//PREDICTED: P2X purinoceptor 6 isoform X2 [Homo sapiens];gi|685568369|ref|XP_009215111.1|//PREDICTED: P2X purinoceptor 6 isoform X1 [Papio anubis];gi|685568375|ref|XP_009215114.1|//PREDICTED: P2X purinoceptor 6 isoform X4 [Papio anubis];gi|694981958|ref|XP_009436126.1|//PREDICTED: P2X purinoceptor 6 isoform X3 [Pan troglodytes];gi|530420539|ref|XP_005261876.1|//PREDICTED: P2X purinoceptor 6 isoform X4 [Homo sapiens]"]
[8153,4169,1.83,0.62,-1.56150352789717,0.000109655184313726,"Down",1.86552e-5,"RND2","GO:0005768//endosome;GO:0001669//acrosomal vesicle","GO:0005515//protein binding;GO:0032561//guanyl ribonucleotide binding;GO:0017111//nucleoside-triphosphatase activity","GO:0035556//intracellular signal transduction;GO:0009207//purine ribonucleoside triphosphate catabolic process","K07858//Rho family GTPase 2","gi|675725244|ref|XP_008964768.1|//PREDICTED: rho-related GTP-binding protein RhoN isoform X3 [Pan paniscus];gi|119581323|gb|EAW60919.1|//Rho family GTPase 2, isoform CRA_a [Homo sapiens];gi|4885581|ref|NP_005431.1|//rho-related GTP-binding protein RhoN [Homo sapiens]"]
[1953,7055,4.6,1.56,-1.56008783208213,2.69521387048711e-17,"Down",1.162132e-18,"MEGF6","NA","GO:0046872//metal ion binding","NA","K02258//cytochrome c oxidase assembly protein subunit 11","gi|767902860|ref|XP_011539190.1|//PREDICTED: multiple epidermal growth factor-like domains protein 6 isoform X5 [Homo sapiens];gi|767902853|ref|XP_011539187.1|//PREDICTED: multiple epidermal growth factor-like domains protein 6 isoform X1 [Homo sapiens];gi|767902855|ref|XP_011539188.1|//PREDICTED: multiple epidermal growth factor-like domains protein 6 isoform X2 [Homo sapiens];gi|767902858|ref|XP_011539189.1|//PREDICTED: multiple epidermal growth factor-like domains protein 6 isoform X4 [Homo sapiens];gi|72534475|dbj|BAE19678.1|//hypothetical protein [Homo sapiens];gi|578798516|ref|XP_006710469.1|//PREDICTED: multiple epidermal growth factor-like domains protein 6 isoform X3 [Homo sapiens]"]
[2764,4125,47.65,16.16,-1.56004901604551,4.56440895e-104,"Down",2.2557e-106,"GMFB","GO:0044464//cell part","GO:0060089//molecular transducer activity;GO:0008092//cytoskeletal protein binding;GO:0019887//protein kinase regulator activity;GO:0005102//receptor binding","GO:0006464//cellular protein modification process;GO:0023052//signaling;GO:0048731//system development","K20368//protein cornichon;K08870//twinfilin","gi|675690160|ref|XP_009004309.1|//PREDICTED: glia maturation factor beta [Callithrix jacchus]"]
[728392,1503,28.12,9.61,-1.54898825829879,4.50179303862333e-22,"Down",1.454434e-23,"LOC728392","NA","NA","NA","K12798//NACHT, LRR and PYD domains-containing protein 1","gi|694989983|ref|XP_529926.4|//PREDICTED: uncharacterized protein LOC455250 [Pan troglodytes]"]
[4781,8760,3.74,1.29,-1.53566720446438,5.50614812359551e-17,"Down",2.42178e-18,"NFIB","GO:0031981//nuclear lumen","GO:0043566//structure-specific DNA binding;GO:0003676//nucleic acid binding;GO:0001071//nucleic acid binding transcription factor activity","GO:0008283//cell proliferation;GO:0006351//transcription, DNA-templated;GO:0007420//brain development;GO:0006259//DNA metabolic process;GO:0030323//respiratory tube development;GO:0007606//sensory perception of chemical stimulus","K09169//nuclear factor I/B","gi|299758476|ref|NP_001177666.1|//nuclear factor 1 B-type isoform 1 [Homo sapiens];gi|578816502|ref|XP_006716836.1|//PREDICTED: nuclear factor 1 B-type isoform X2 [Homo sapiens];gi|119579099|gb|EAW58695.1|//nuclear factor I/B, isoform CRA_b [Homo sapiens] ;gi|545201555|ref|XP_005605072.1|//PREDICTED: nuclear factor 1 B-type isoform X5 [Equus caballus];gi|119579100|gb|EAW58696.1|//nuclear factor I/B, isoform CRA_c, partial [Homo sapiens];gi|578816505|ref|XP_006716837.1|//PREDICTED: nuclear factor 1 B-type isoform X5 [Homo sapiens];gi|299758479|ref|NP_001177667.1|//nuclear factor 1 B-type isoform 2 [Homo sapiens];gi|93004092|ref|NP_005587.2|//nuclear factor 1 B-type isoform 3 [Homo sapiens];gi|530389917|ref|XP_005251525.1|//PREDICTED: nuclear factor 1 B-type isoform X3 [Homo sapiens];gi|767954910|ref|XP_011516188.1|//PREDICTED: nuclear factor 1 B-type isoform X8 [Homo sapiens];gi|578816507|ref|XP_006716838.1|//PREDICTED: nuclear factor 1 B-type isoform X6 [Homo sapiens];gi|767954912|ref|XP_011516189.1|//PREDICTED: nuclear factor 1 B-type isoform X9 [Homo sapiens];gi|119579102|gb|EAW58698.1|//nuclear factor I/B, isoform CRA_e [Homo sapiens]"]
[4162,3263,9.47,3.28,-1.5296686108503,2.70353032103004e-17,"Down",1.167388e-18,"MCAM","GO:0031224//intrinsic component of membrane","NA","GO:0032502//developmental process;GO:0009987//cellular process","K06534//melanoma cell adhesion molecule","gi|62089436|dbj|BAD93162.1|//Melanoma cell adhesion molecule variant [Homo sapiens]"]
[576,5297,2.71,0.94,-1.52756018967623,5.65920959497645e-7,"Down",6.68072e-8,"ADGRB2","GO:0031224//intrinsic component of membrane","NA","GO:0007186//G-protein coupled receptor signaling pathway","K04597//brain-specific angiogenesis inhibitor 2","gi|767905296|ref|XP_011540152.1|//PREDICTED: brain-specific angiogenesis inhibitor 2 isoform X3 [Homo sapiens];gi|661567369|ref|NP_001281264.1|//adhesion G protein-coupled receptor B2 isoform 1 preproprotein [Homo sapiens];gi|767905310|ref|XP_011540159.1|//PREDICTED: brain-specific angiogenesis inhibitor 2 isoform X10 [Homo sapiens];gi|661567371|ref|NP_001281265.1|//adhesion G protein-coupled receptor B2 isoform 2 preproprotein [Homo sapiens];gi|767905298|ref|XP_011540153.1|//PREDICTED: brain-specific angiogenesis inhibitor 2 isoform X4 [Homo sapiens];gi|767905308|ref|XP_011540158.1|//PREDICTED: brain-specific angiogenesis inhibitor 2 isoform X9 [Homo sapiens];gi|767905300|ref|XP_011540154.1|//PREDICTED: brain-specific angiogenesis inhibitor 2 isoform X5 [Homo sapiens];gi|767905304|ref|XP_011540156.1|//PREDICTED: brain-specific angiogenesis inhibitor 2 isoform X7 [Homo sapiens];gi|229462818|sp|O60241.2|AGRB2_HUMAN//RecName: Full=Adhesion G protein-coupled receptor B2; AltName: Full=Brain-specific angiogenesis inhibitor 2; Flags: Precursor;gi|767905306|ref|XP_011540157.1|//PREDICTED: brain-specific angiogenesis inhibitor 2 isoform X8 [Homo sapiens];gi|767905302|ref|XP_011540155.1|//PREDICTED: brain-specific angiogenesis inhibitor 2 isoform X6 [Homo sapiens];gi|675789080|ref|XP_008951724.1|//PREDICTED: adhesion G protein-coupled receptor B2 isoform X1 [Pan paniscus]"]
[149345,1659,14.07,4.9,-1.52176867423396,4.12748990220518e-12,"Down",2.65936e-13,"SHISA4","GO:0031224//intrinsic component of membrane","NA","NA","K10135//scotin","gi|966922730|ref|XP_014975759.1|//PREDICTED: LOW QUALITY PROTEIN: protein shisa-4 [Macaca mulatta];gi|16306971|gb|AAH09558.1|//SHISA4 protein, partial [Homo sapiens];gi|269973884|ref|NP_937792.2|//protein shisa-4 precursor [Homo sapiens]"]
[26002,2880,5.82,2.03,-1.51953942572311,1.4109022375e-9,"Down",1.171394e-10,"MOXD1","GO:0031224//intrinsic component of membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0031090//organelle membrane","GO:0046914//transition metal ion binding;GO:0016715//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen","GO:0006576//cellular biogenic amine metabolic process","K00503//dopamine beta-monooxygenase [EC:1.14.17.1];K15266//dimethyladenosine transferase 1, mitochondrial [EC:2.1.1.-]","gi|119568419|gb|EAW48034.1|//monooxygenase, DBH-like 1, isoform CRA_c [Homo sapiens];gi|635076408|ref|XP_008005210.1|//PREDICTED: DBH-like monooxygenase protein 1 isoform X1 [Chlorocebus sabaeus];gi|694918339|ref|XP_009450294.1|//PREDICTED: DBH-like monooxygenase protein 1 isoform X2 [Pan troglodytes]"]
[9064,4287,6.75,2.37,-1.51000044303993,6.20900948648649e-14,"Down",3.40598e-15,"MAP3K6","NA","GO:0046872//metal ion binding;GO:0032559//adenyl ribonucleotide binding;GO:0004702//signal transducer, downstream of receptor, with serine/threonine kinase activity","GO:0000187//activation of MAPK activity","K04425//mitogen-activated protein kinase kinase kinase 6 [EC:2.7.11.25]","gi|662236841|ref|NP_001284538.1|//mitogen-activated protein kinase kinase kinase 6 isoform 2 [Homo sapiens];gi|45827809|ref|NP_004663.3|//mitogen-activated protein kinase kinase kinase 6 isoform 1 [Homo sapiens]"]
[3033,1968,8.74,3.07,-1.50939462413042,3.4498050376569e-9,"Down",3.05598e-10,"HADH","GO:0044429//mitochondrial part;GO:0019866//organelle inner membrane","GO:0016616//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0051287//NAD binding","GO:0043434//response to peptide hormone;GO:0009062//fatty acid catabolic process;GO:0050796//regulation of insulin secretion","K00022//3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]","gi|119626624|gb|EAX06219.1|//L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain, isoform CRA_b [Homo sapiens];gi|119626623|gb|EAX06218.1|//L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain, isoform CRA_a [Homo sapiens];gi|530377639|ref|XP_005263029.1|//PREDICTED: hydroxyacyl-coenzyme A dehydrogenase, mitochondrial isoform X1 [Homo sapiens]"]
[342918,765,10.16,3.57,-1.50890442274307,0.000219509501298701,"Down",3.96766e-5,"C19orf81","NA","NA","NA","NA","gi|304307731|ref|NP_001182005.1|//putative uncharacterized protein C19orf81 [Homo sapiens];gi|768008853|ref|XP_011525212.1|//PREDICTED: putative uncharacterized protein C19orf81 isoform X2 [Homo sapiens]"]
[23336,6862,6,2.11,-1.5077195017887,1.06384360770578e-20,"Down",3.7525e-22,"SYNM","GO:0045111//intermediate filament cytoskeleton;GO:0043234//protein complex;GO:0030016//myofibril;GO:0070161//anchoring junction","GO:0008092//cytoskeletal protein binding;GO:0005198//structural molecule activity;GO:0032403//protein complex binding","GO:0007010//cytoskeleton organization","K10376//desmuslin","gi|112382237|ref|NP_663780.2|//synemin isoform A [Homo sapiens];gi|112382239|ref|NP_056101.5|//synemin isoform B [Homo sapiens]"]
[85442,5613,1.25,0.44,-1.50635266602479,0.000355967716770186,"Down",6.72662e-5,"KNDC1","GO:0044297//cell body;GO:0043234//protein complex;GO:0043005//neuron projection","GO:0004672//protein kinase activity","GO:0021533//cell differentiation in hindbrain;GO:0010769//regulation of cell morphogenesis involved in differentiation;GO:0009966//regulation of signal transduction","K04351//Rap guanine nucleotide exchange factor 4;K02374//tyrosine-protein phosphatase non-receptor type 13;K17636//ral guanine nucleotide dissociation stimulator-like 2;K08019//Rap guanine nucleotide exchange factor 5;K02098//spire;K08018//Rap guanine nucleotide exchange factor 2","gi|116268127|ref|NP_689856.6|//protein very KIND [Homo sapiens]"]
[23363,3960,32.64,11.5,-1.50500719613976,5.99731720268456e-66,"Down",5.52014e-68,"OBSL1","GO:0031224//intrinsic component of membrane;GO:0044464//cell part;GO:0044291//cell-cell contact zone;GO:0031674//I band;GO:0031672//A band;GO:0030017//sarcomere;GO:0044444//cytoplasmic part;GO:0000139//Golgi membrane","GO:0043169//cation binding;GO:0030674//protein binding, bridging;GO:0015020//glucuronosyltransferase activity;GO:0008376//acetylgalactosaminyltransferase activity","GO:0007010//cytoskeleton organization;GO:0030239//myofibril assembly","K19574//obscurin-like protein 1","gi|767917343|ref|XP_011509168.1|//PREDICTED: obscurin-like protein 1 isoform X13 [Homo sapiens];gi|144226847|ref|NP_056126.1|//obscurin-like protein 1 isoform 1 precursor [Homo sapiens];gi|530370085|ref|XP_005246484.1|//PREDICTED: obscurin-like protein 1 isoform X14 [Homo sapiens];gi|767917328|ref|XP_011509161.1|//PREDICTED: obscurin-like protein 1 isoform X6 [Homo sapiens];gi|530370079|ref|XP_005246481.1|//PREDICTED: obscurin-like protein 1 isoform X8 [Homo sapiens];gi|767917333|ref|XP_011509163.1|//PREDICTED: obscurin-like protein 1 isoform X9 [Homo sapiens];gi|767917330|ref|XP_011509162.1|//PREDICTED: obscurin-like protein 1 isoform X7 [Homo sapiens];gi|13938170|gb|AAH07201.1|//OBSL1 protein, partial [Homo sapiens];gi|767917324|ref|XP_011509159.1|//PREDICTED: obscurin-like protein 1 isoform X4 [Homo sapiens];gi|767917339|ref|XP_011509166.1|//PREDICTED: obscurin-like protein 1 isoform X12 [Homo sapiens];gi|291084534|ref|NP_001166902.1|//obscurin-like protein 1 isoform 2 precursor [Homo sapiens];gi|767917322|ref|XP_011509158.1|//PREDICTED: obscurin-like protein 1 isoform X3 [Homo sapiens];gi|767917320|ref|XP_011509157.1|//PREDICTED: obscurin-like protein 1 isoform X2 [Homo sapiens]"]
[148398,2575,3.6,1.27,-1.50316840955751,3.93588740204563e-5,"Down",6.18052e-6,"SAMD11","NA","NA","NA","K11456//polyhomeotic-like protein 1;K11457//polyhomeotic-like protein 2","gi|76881819|ref|NP_689699.2|//sterile alpha motif domain-containing protein 11 [Homo sapiens]"]
[5654,2138,3.08,1.09,-1.49860221591797,0.000703585130530165,"Down",0.0001426468,"HTRA1","GO:0044421//extracellular region part","GO:0004175//endopeptidase activity;GO:0019838//growth factor binding","GO:0007179//transforming growth factor beta receptor signaling pathway;GO:0019538//protein metabolic process;GO:0030509//BMP signaling pathway;GO:0016049//cell growth","K08784//HtrA serine peptidase 1 [EC:3.4.21.-]","gi|4506141|ref|NP_002766.1|//serine protease HTRA1 precursor [Homo sapiens]"]
[9249,1702,20.91,7.42,-1.49470196996878,2.45322742680412e-20,"Down",8.81998e-22,"DHRS3","GO:0031224//intrinsic component of membrane","GO:0008106//alcohol dehydrogenase (NADP+) activity;GO:0005488//binding","GO:0001523//retinoid metabolic process;GO:0050953//sensory perception of light stimulus","K11146//short-chain dehydrogenase/reductase 3 [EC:1.1.1.300]","gi|76253697|ref|NP_776605.2|//short-chain dehydrogenase/reductase 3 [Bos taurus];gi|3450828|gb|AAC63263.1|//retinal short-chain dehydrogenase/reductase retSDR1 [Homo sapiens];gi|578800093|ref|XP_006711099.1|//PREDICTED: short-chain dehydrogenase/reductase 3 isoform X3 [Homo sapiens];gi|725587345|ref|XP_010344804.1|//PREDICTED: short-chain dehydrogenase/reductase 3 isoform X1 [Saimiri boliviensis boliviensis];gi|31543615|ref|NP_004744.2|//short-chain dehydrogenase/reductase 3 isoform 1 [Homo sapiens]"]
[57158,3929,2.31,0.82,-1.49419703679797,5.54138136484941e-5,"Down",8.9789e-6,"JPH2","GO:0031224//intrinsic component of membrane;GO:0031674//I band;GO:0033017//sarcoplasmic reticulum membrane","NA","GO:0007204//positive regulation of cytosolic calcium ion concentration;GO:0032412//regulation of ion transmembrane transporter activity","K19530//junctophilin","gi|21704281|ref|NP_065166.2|//junctophilin-2 isoform 1 [Homo sapiens];gi|578836085|ref|XP_006723896.1|//PREDICTED: junctophilin-2 isoform X2 [Homo sapiens];gi|431894410|gb|ELK04210.1|//Junctophilin-2 [Pteropus alecto]"]
[5724,4109,1.66,0.59,-1.49239638198508,0.00037582228987013,"Down",7.15056e-5,"PTAFR","GO:0031981//nuclear lumen;GO:0016021//integral component of membrane","GO:0008289//lipid binding;GO:0001530//lipopolysaccharide binding;GO:0004930//G-protein coupled receptor activity","GO:0048017//inositol lipid-mediated signaling;GO:0002376//immune system process;GO:0006952//defense response;GO:0032957//inositol trisphosphate metabolic process;GO:0032501//multicellular organismal process;GO:0019221//cytokine-mediated signaling pathway;GO:0002237//response to molecule of bacterial origin","K04279//platelet-activating factor receptor","gi|4506241|ref|NP_000943.1|//platelet-activating factor receptor [Homo sapiens]"]
[5318,4439,6.15,2.19,-1.48965554062543,5.41491343728814e-14,"Down",2.96034e-15,"PKP2","GO:0043231//intracellular membrane-bounded organelle;GO:0031224//intrinsic component of membrane;GO:0005911//cell-cell junction","NA","GO:0007155//cell adhesion","K12642//plakophilin 2","gi|148664226|ref|NP_004563.2|//plakophilin-2 isoform 2b [Homo sapiens];gi|148664186|ref|NP_001005242.2|//plakophilin-2 isoform 2a [Homo sapiens]"]
[54510,4084,1.74,0.62,-1.48874718546185,9.2267332513181e-6,"Down",1.29726e-6,"PCDH18","GO:0031224//intrinsic component of membrane","GO:0046872//metal ion binding","GO:0016337//single organismal cell-cell adhesion;GO:0007417//central nervous system development","K16499//protocadherin delta 2","gi|14589929|ref|NP_061908.1|//protocadherin-18 isoform 1 precursor [Homo sapiens];gi|989980559|ref|XP_015449438.1|//PREDICTED: protocadherin-18 isoform X3 [Pteropus alecto];gi|578809178|ref|XP_006714302.1|//PREDICTED: protocadherin-18 isoform X1 [Homo sapiens];gi|664806063|ref|NP_001287757.1|//protocadherin-18 isoform 2 precursor [Homo sapiens]"]
[5584,4884,22.1,7.89,-1.48594916426534,1.752856875e-53,"Down",2.079e-55,"PRKCI","GO:0043231//intracellular membrane-bounded organelle;GO:0044459//plasma membrane part;GO:0030427//site of polarized growth;GO:0044444//cytoplasmic part","GO:0008289//lipid binding;GO:0004674//protein serine/threonine kinase activity;GO:0032559//adenyl ribonucleotide binding;GO:0046914//transition metal ion binding","GO:0006605//protein targeting;GO:0007043//cell-cell junction assembly;GO:0030036//actin cytoskeleton organization;GO:0032868//response to insulin;GO:0001754//eye photoreceptor cell differentiation;GO:0043066//negative regulation of apoptotic process;GO:0010828//positive regulation of glucose transport;GO:0035088//establishment or maintenance of apical/basal cell polarity;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0048522//positive regulation of cellular process;GO:0006464//cellular protein modification process","K06069//atypical protein kinase C iota type [EC:2.7.11.13]","gi|332818337|ref|XP_526377.3|//PREDICTED: protein kinase C iota type [Pan troglodytes];gi|395843892|ref|XP_003794706.1|//PREDICTED: protein kinase C iota type [Otolemur garnettii];gi|432274|gb|AAA60171.1|//protein kinase C iota [Homo sapiens]"]
[23129,5068,10.51,3.76,-1.48295810228454,2.15071139896373e-20,"Down",7.6925e-22,"PLXND1","GO:0031224//intrinsic component of membrane","GO:0004888//transmembrane signaling receptor activity","GO:0001525//angiogenesis;GO:0060600//dichotomous subdivision of an epithelial terminal unit;GO:0023052//signaling;GO:0006935//chemotaxis","K06822//plexin D","gi|767926138|ref|XP_011510892.1|//PREDICTED: plexin-D1 isoform X3 [Homo sapiens];gi|767926142|ref|XP_011510894.1|//PREDICTED: plexin-D1 isoform X5 [Homo sapiens];gi|157694524|ref|NP_055918.2|//plexin-D1 precursor [Homo sapiens];gi|296452982|sp|Q9Y4D7.3|PLXD1_HUMAN//RecName: Full=Plexin-D1; Flags: Precursor;gi|767926135|ref|XP_011510891.1|//PREDICTED: plexin-D1 isoform X2 [Homo sapiens];gi|767926140|ref|XP_011510893.1|//PREDICTED: plexin-D1 isoform X4 [Homo sapiens];gi|767926133|ref|XP_011510890.1|//PREDICTED: plexin-D1 isoform X1 [Homo sapiens]"]
[116461,1909,30.73,11.02,-1.4795235430218,6.5190441253012e-28,"Down",1.67124e-29,"TSEN15","GO:0031981//nuclear lumen;GO:0005634//nucleus","GO:0005488//binding","GO:0006396//RNA processing;GO:0006399//tRNA metabolic process","K15324//tRNA-splicing endonuclease subunit Sen15","gi|694890645|ref|XP_009437774.1|//PREDICTED: tRNA-splicing endonuclease subunit Sen15 isoform X2 [Pan troglodytes];gi|767908285|ref|XP_011507441.1|//PREDICTED: tRNA-splicing endonuclease subunit Sen15 isoform X2 [Homo sapiens];gi|12620198|gb|AAG60614.1|AF288394_1//C1orf19 [Homo sapiens]"]
[85012,1142,16.06,5.76,-1.479331176075,2.89220246066619e-9,"Down",2.52094e-10,"TCEAL3","NA","NA","NA","K13749//solute carrier family 24 (sodium/potassium/calcium exchanger), member 1;K19607//X-linked retinitis pigmentosa GTPase regulator;K05628//arginine-glutamic acid dipeptide repeats protein","gi|725597772|ref|XP_010349173.1|//PREDICTED: transcription elongation factor A protein-like 6 isoform X1 [Saimiri boliviensis boliviensis]"]
[57460,5231,11.18,4.02,-1.47565278166426,3.7670955106599e-29,"Down",9.16874e-31,"PPM1H","NA","GO:0016791//phosphatase activity","NA","K17503//protein phosphatase 1H [EC:3.1.3.16]","gi|402886692|ref|XP_003906758.1|//PREDICTED: LOW QUALITY PROTEIN: protein phosphatase 1H [Papio anubis];gi|332207388|ref|XP_003252778.1|//PREDICTED: protein phosphatase 1H [Nomascus leucogenys]"]
[120939,2646,3.53,1.27,-1.47483968649901,5.3475368790538e-5,"Down",8.6582e-6,"TMEM52B","GO:0031224//intrinsic component of membrane","NA","NA","K12581//CCR4-NOT transcription complex subunit 7/8;K17985//activating molecule in BECN1-regulated autophagy protein 1;K01064//wingless-type MMTV integration site family, member 9","gi|23308507|ref|NP_694567.1|//transmembrane protein 52B isoform 1 [Homo sapiens];gi|557636675|ref|NP_001073283.1|//transmembrane protein 52B isoform 2 precursor [Homo sapiens]"]
[83463,1729,21.81,7.86,-1.47238855238214,7.34254643265306e-13,"Down",4.44508e-14,"MXD3","GO:0043231//intracellular membrane-bounded organelle","GO:0003676//nucleic acid binding","NA","K09114//MAX dimerization protein","gi|219283190|ref|NP_001136407.1|//max dimerization protein 3 isoform b [Homo sapiens];gi|194382566|dbj|BAG64453.1|//unnamed protein product [Homo sapiens]"]
[5530,4630,6.63,2.39,-1.47199825213184,2.52661489509434e-15,"Down",1.240832e-16,"PPP3CA","GO:0008287//protein serine/threonine phosphatase complex;GO:0031981//nuclear lumen;GO:0031674//I band;GO:0044444//cytoplasmic part","GO:0046872//metal ion binding;GO:0005515//protein binding;GO:0004721//phosphoprotein phosphatase activity;GO:0004722//protein serine/threonine phosphatase activity;GO:0046983//protein dimerization activity","GO:0014075//response to amine;GO:0051969//regulation of transmission of nerve impulse;GO:0006605//protein targeting;GO:0048747//muscle fiber development;GO:0050796//regulation of insulin secretion;GO:0001678//cellular glucose homeostasis;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0006464//cellular protein modification process;GO:0022402//cell cycle process;GO:0050896//response to stimulus;GO:0051899//membrane depolarization;GO:0017158//regulation of calcium ion-dependent exocytosis;GO:0006796//phosphate-containing compound metabolic process;GO:0070838//divalent metal ion transport","K04348//serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]","gi|931570229|ref|XP_014200201.1|//PREDICTED: serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X3 [Pan paniscus];gi|926693529|ref|XP_013819948.1|//PREDICTED: serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [Capra hircus]"]
[152007,2026,34.17,12.32,-1.47172799173437,5.28239029367089e-35,"Down",1.031156e-36,"GLIPR2","GO:0043231//intracellular membrane-bounded organelle;GO:0012505//endomembrane system","NA","NA","K19919//cysteine-rich secretory protein;K19867//LIM domain-binding protein 3;K14388//solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12","gi|558757329|ref|NP_001273939.1|//Golgi-associated plant pathogenesis-related protein 1 isoform b [Homo sapiens];gi|558757349|ref|NP_001273942.1|//Golgi-associated plant pathogenesis-related protein 1 isoform e [Homo sapiens];gi|119578719|gb|EAW58315.1|//chromosome 9 open reading frame 19, isoform CRA_a, partial [Homo sapiens];gi|558757337|ref|NP_001273943.1|//Golgi-associated plant pathogenesis-related protein 1 isoform f [Homo sapiens] ;gi|11641247|ref|NP_071738.1|//Golgi-associated plant pathogenesis-related protein 1 isoform a [Homo sapiens];gi|795353367|ref|XP_011746532.1|//PREDICTED: golgi-associated plant pathogenesis-related protein 1 isoform X2 [Macaca nemestrina]"]
[259232,6400,3.02,1.09,-1.47022041454815,6.92594555574762e-11,"Down",4.95016e-12,"NALCN","GO:0031224//intrinsic component of membrane","GO:0005261//cation channel activity","GO:0030001//metal ion transport","K04851//voltage-dependent calcium channel L type alpha-1D","gi|767978827|ref|XP_011519371.1|//PREDICTED: sodium leak channel non-selective protein isoform X3 [Homo sapiens];gi|817341522|ref|XP_012296388.1|//PREDICTED: sodium leak channel non-selective protein isoform X3 [Aotus nancymaae];gi|694954610|ref|XP_009425466.1|//PREDICTED: sodium leak channel non-selective protein isoform X4 [Pan troglodytes];gi|767978823|ref|XP_011519369.1|//PREDICTED: sodium leak channel non-selective protein isoform X2 [Homo sapiens]"]
[4320,2306,4.87,1.76,-1.46834634344504,5.38901113043478e-6,"Down",7.2739e-7,"MMP11","GO:0031012//extracellular matrix","GO:0004175//endopeptidase activity;GO:0046914//transition metal ion binding","GO:0032963//collagen metabolic process;GO:0019538//protein metabolic process","K07993//matrix metalloproteinase-11 (stromelysin 3) [EC:3.4.24.-]","gi|456257|emb|CAA40918.1|//stromelysin-3 precursor [Homo sapiens];gi|119580008|gb|EAW59604.1|//matrix metallopeptidase 11 (stromelysin 3), isoform CRA_b [Homo sapiens] "]
[56977,8103,0.83,0.3,-1.46814883573841,0.000829995056834532,"Down",0.0001710442,"STOX2","NA","NA","GO:0001890//placenta development","NA","gi|767932364|ref|XP_011530433.1|//PREDICTED: storkhead-box protein 2 isoform X3 [Homo sapiens];gi|148703646|gb|EDL35593.1|//mCG115488, isoform CRA_a [Mus musculus];gi|694909741|ref|XP_009446900.1|//PREDICTED: storkhead-box protein 2 isoform X2 [Pan troglodytes];gi|767932359|ref|XP_011530431.1|//PREDICTED: storkhead-box protein 2 isoform X1 [Homo sapiens];gi|55742730|ref|NP_064610.1|//storkhead-box protein 2 [Homo sapiens];gi|767932361|ref|XP_011530432.1|//PREDICTED: storkhead-box protein 2 isoform X2 [Homo sapiens]"]
[5698,1048,35.42,12.88,-1.4594316186373,1.02218946133333e-17,"Down",4.26228e-19,"PSMB9","GO:0043231//intracellular membrane-bounded organelle;GO:0000502//proteasome complex","GO:0004175//endopeptidase activity","GO:0030330//DNA damage response, signal transduction by p53 class mediator;GO:0016070//RNA metabolic process;GO:0006520//cellular amino acid metabolic process;GO:0051320//S phase;GO:0007050//cell cycle arrest;GO:0006915//apoptotic process;GO:0043161//proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051439//regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle;GO:0051704//multi-organism process","K02741//20S proteasome subunit beta 9 [EC:3.4.25.1]","gi|4506205|ref|NP_002791.1|//proteasome subunit beta type-9 precursor [Homo sapiens]"]
[79778,3234,3.04,1.11,-1.45351164709348,0.000104565857424298,"Down",1.77054e-5,"MICALL2","GO:0005856//cytoskeleton;GO:0015629//actin cytoskeleton;GO:0043296//apical junction complex","GO:0046872//metal ion binding;GO:0046914//transition metal ion binding","GO:0016192//vesicle-mediated transport","K21068//MICAL-like protein 2","gi|675754683|ref|XP_008971386.1|//PREDICTED: MICAL-like protein 2 isoform X2 [Pan paniscus];gi|33667117|ref|NP_891554.1|//MICAL-like protein 2 [Homo sapiens];gi|767945806|ref|XP_011513822.1|//PREDICTED: MICAL-like protein 2 isoform X1 [Homo sapiens];gi|767945810|ref|XP_011513824.1|//PREDICTED: MICAL-like protein 2 isoform X3 [Homo sapiens];gi|767945812|ref|XP_011513825.1|//PREDICTED: MICAL-like protein 2 isoform X4 [Homo sapiens];gi|767945808|ref|XP_011513823.1|//PREDICTED: MICAL-like protein 2 isoform X2 [Homo sapiens]"]
[3992,4398,45.48,16.61,-1.45318018092987,6.12011973913043e-90,"Down",3.4782e-92,"FADS1","GO:0043231//intracellular membrane-bounded organelle;GO:0031224//intrinsic component of membrane;GO:0031090//organelle membrane","GO:0005506//iron ion binding;GO:0016717//oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water","GO:0000038//very long-chain fatty acid metabolic process;GO:0043434//response to peptide hormone;GO:0006091//generation of precursor metabolites and energy;GO:0034285//response to disaccharide;GO:0006636//unsaturated fatty acid biosynthetic process;GO:0006644//phospholipid metabolic process;GO:0050793//regulation of developmental process;GO:0033273//response to vitamin;GO:0031669//cellular response to nutrient levels;GO:0051234//establishment of localization","K10224//acyl-CoA (8-3)-desaturase (Delta-5 desaturase) [EC:1.14.19.44]","gi|635012964|ref|XP_007994105.1|//PREDICTED: fatty acid desaturase 1 isoform X1 [Chlorocebus sabaeus];gi|767968153|ref|XP_011543324.1|//PREDICTED: fatty acid desaturase 1 isoform X1 [Homo sapiens]"]
[1606,2686,8.58,3.14,-1.45021308860792,4.47931818534863e-11,"Down",3.13508e-12,"DGKA","GO:0016020//membrane;GO:0044444//cytoplasmic part","GO:0008289//lipid binding;GO:0046872//metal ion binding;GO:0032559//adenyl ribonucleotide binding;GO:0016301//kinase activity","GO:0007186//G-protein coupled receptor signaling pathway;GO:0001775//cell activation;GO:0007599//hemostasis","K00901//diacylglycerol kinase (ATP) [EC:2.7.1.107]","gi|530399854|ref|XP_005268746.1|//PREDICTED: diacylglycerol kinase alpha isoform X5 [Homo sapiens];gi|31542504|ref|NP_001336.2|//diacylglycerol kinase alpha [Homo sapiens];gi|507532958|ref|XP_004650547.1|//PREDICTED: diacylglycerol kinase alpha [Jaculus jaculus];gi|982281800|ref|XP_015286496.1|//PREDICTED: diacylglycerol kinase alpha isoform X1 [Macaca fascicularis];gi|767973388|ref|XP_011536296.1|//PREDICTED: diacylglycerol kinase alpha isoform X4 [Homo sapiens];gi|530399852|ref|XP_005268745.1|//PREDICTED: diacylglycerol kinase alpha isoform X2 [Homo sapiens]"]
[51390,2609,5.34,1.96,-1.44598608757235,7.08403736445242e-6,"Down",9.74996e-7,"AIG1","GO:0031224//intrinsic component of membrane","NA","NA","K17985//activating molecule in BECN1-regulated autophagy protein 1;K09650//rhomboid-like protein [EC:3.4.21.105];K08267//rapamycin-insensitive companion of mTOR","gi|767942986|ref|XP_011534186.1|//PREDICTED: androgen-induced gene 1 protein isoform X5 [Homo sapiens];gi|34364768|emb|CAE45823.1|//hypothetical protein [Homo sapiens];gi|40316941|ref|NP_057192.2|//androgen-induced gene 1 protein isoform a [Homo sapiens];gi|767942989|ref|XP_011534187.1|//PREDICTED: androgen-induced gene 1 protein isoform X6 [Homo sapiens];gi|795315371|ref|XP_011817432.1|//PREDICTED: androgen-induced gene 1 protein isoform X4 [Colobus angolensis palliatus];gi|675713618|ref|XP_008962184.1|//PREDICTED: androgen-induced gene 1 protein isoform X4 [Pan paniscus];gi|767942982|ref|XP_011534184.1|//PREDICTED: androgen-induced gene 1 protein isoform X3 [Homo sapiens];gi|767942979|ref|XP_011534183.1|//PREDICTED: androgen-induced gene 1 protein isoform X1 [Homo sapiens];gi|675713611|ref|XP_008962182.1|//PREDICTED: androgen-induced gene 1 protein isoform X2 [Pan paniscus];gi|694918620|ref|XP_009450393.1|//PREDICTED: LOW QUALITY PROTEIN: androgen-induced gene 1 protein [Pan troglodytes]"]
[11173,5552,1.47,0.54,-1.4447848426729,0.000240975575642761,"Down",4.40032e-5,"ADAMTS7","GO:0031012//extracellular matrix;GO:0044464//cell part","GO:0004175//endopeptidase activity;GO:0046914//transition metal ion binding","GO:0019538//protein metabolic process","K08622//a disintegrin and metalloproteinase with thrombospondin motifs 7 [EC:3.4.24.-]","gi|38683827|ref|NP_055087.2|//A disintegrin and metalloproteinase with thrombospondin motifs 7 preproprotein [Homo sapiens];gi|767983147|ref|XP_011519468.1|//PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform X2 [Homo sapiens];gi|530405339|ref|XP_005254194.1|//PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 7 isoform X1 [Homo sapiens]"]
[79699,6413,20.22,7.44,-1.44240847079498,1.43308524055814e-46,"Down",1.903344e-48,"ZYG11B","NA","GO:0005488//binding","NA","K10350//Zyg-11 protein homolog","gi|725553332|ref|XP_010349191.1|//PREDICTED: protein zyg-11 homolog B [Saimiri boliviensis boliviensis];gi|578799765|ref|XP_006710961.1|//PREDICTED: protein zyg-11 homolog B isoform X1 [Homo sapiens];gi|55742693|ref|NP_078922.1|//protein zyg-11 homolog B [Homo sapiens]"]
[60481,2933,46.34,17.06,-1.44164039754653,2.94839209180328e-74,"Down",2.22204e-76,"ELOVL5","GO:0043231//intracellular membrane-bounded organelle;GO:0031224//intrinsic component of membrane;GO:0031090//organelle membrane","GO:0005488//binding;GO:0004312//fatty acid synthase activity","GO:0000038//very long-chain fatty acid metabolic process;GO:0035336//long-chain fatty-acyl-CoA metabolic process;GO:0006641//triglyceride metabolic process;GO:0019368//fatty acid elongation, unsaturated fatty acid","K02910//large subunit ribosomal protein L31e;K02960//small subunit ribosomal protein S16e;K10244//elongation of very long chain fatty acids protein 5 [EC:2.3.1.199]","gi|119624825|gb|EAX04420.1|//ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast), isoform CRA_f [Homo sapiens];gi|397517588|ref|XP_003828991.1|//PREDICTED: elongation of very long chain fatty acids protein 5 isoform X1 [Pan paniscus];gi|338827646|ref|NP_001229757.1|//elongation of very long chain fatty acids protein 5 isoform 2 [Homo sapiens] ;gi|675653043|ref|XP_008992834.1|//PREDICTED: elongation of very long chain fatty acids protein 5 isoform X2 [Callithrix jacchus]"]
[2736,6707,1.35,0.5,-1.43295940727611,9.99046093704246e-5,"Down",1.68606e-5,"GLI2","GO:0043231//intracellular membrane-bounded organelle","GO:0046914//transition metal ion binding;GO:0043565//sequence-specific DNA binding;GO:0001071//nucleic acid binding transcription factor activity","GO:0060033//anatomical structure regression;GO:0001649//osteoblast differentiation;GO:0014070//response to organic cyclic compound;GO:0060562//epithelial tube morphogenesis;GO:0048732//gland development;GO:0006275//regulation of DNA replication;GO:0033077//T cell differentiation in thymus;GO:0007418//ventral midline development;GO:0030323//respiratory tube development;GO:0043009//chordate embryonic development;GO:0001763//morphogenesis of a branching structure;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0021520//spinal cord motor neuron cell fate specification;GO:0008283//cell proliferation;GO:0042472//inner ear morphogenesis;GO:0007380//specification of segmental identity, head;GO:0006935//chemotaxis;GO:0007224//smoothened signaling pathway;GO:0045597//positive regulation of cell differentiation;GO:0042476//odontogenesis;GO:0021536//diencephalon development;GO:0030326//embryonic limb morphogenesis;GO:0048565//digestive tract development;GO:0002062//chondrocyte differentiation;GO:0008544//epidermis development;GO:0012501//programmed cell death;GO:0016331//morphogenesis of embryonic epithelium;GO:0021952//central nervous system projection neuron axonogenesis;GO:0040007//growth;GO:0021521//ventral spinal cord interneuron specification","K16798//zinc finger protein GLI2","gi|931566652|ref|XP_014199424.1|//PREDICTED: zinc finger protein GLI2 isoform X4 [Pan paniscus];gi|767917592|ref|XP_011509272.1|//PREDICTED: zinc finger protein GLI2 isoform X3 [Homo sapiens];gi|578804076|ref|XP_006712485.1|//PREDICTED: zinc finger protein GLI2 isoform X2 [Homo sapiens];gi|767917590|ref|XP_011509271.1|//PREDICTED: zinc finger protein GLI2 isoform X1 [Homo sapiens];gi|86991432|ref|NP_005261.2|//zinc finger protein GLI2 [Homo sapiens]"]
[23471,2964,57.48,21.31,-1.43152946867463,1.24330254113208e-79,"Down",8.14122e-82,"TRAM1","GO:0031224//intrinsic component of membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0031090//organelle membrane","GO:0004871//signal transducer activity;GO:0005488//binding","GO:0006612//protein targeting to membrane","K14010//translocating chain-associated membrane protein 1","gi|55630806|ref|XP_519803.1|//PREDICTED: translocating chain-associated membrane protein 1 [Pan troglodytes]"]
[7145,10231,0.86,0.32,-1.4262647547021,0.00013169288151591,"Down",2.27542e-5,"TNS1","GO:0043232//intracellular non-membrane-bounded organelle;GO:0005924//cell-substrate adherens junction","GO:0008092//cytoskeletal protein binding","NA","K18080//tensin","gi|767919451|ref|XP_011510013.1|//PREDICTED: tensin-1 isoform X1 [Homo sapiens];gi|767919453|ref|XP_011510014.1|//PREDICTED: tensin-1 isoform X2 [Homo sapiens];gi|767919480|ref|XP_011510027.1|//PREDICTED: tensin-1 isoform X13 [Homo sapiens];gi|795647517|ref|XP_011738871.1|//PREDICTED: tensin-1 isoform X7 [Macaca nemestrina];gi|767919459|ref|XP_011510017.1|//PREDICTED: tensin-1 isoform X5 [Homo sapiens];gi|931567401|ref|XP_014199569.1|//PREDICTED: tensin-1 isoform X4 [Pan paniscus];gi|767919455|ref|XP_011510015.1|//PREDICTED: tensin-1 isoform X3 [Homo sapiens];gi|931567397|ref|XP_014199567.1|//PREDICTED: tensin-1 isoform X2 [Pan paniscus];gi|767919465|ref|XP_011510020.1|//PREDICTED: tensin-1 isoform X8 [Homo sapiens];gi|767919463|ref|XP_011510019.1|//PREDICTED: tensin-1 isoform X7 [Homo sapiens];gi|931567395|ref|XP_014199566.1|//PREDICTED: tensin-1 isoform X1 [Pan paniscus];gi|767919461|ref|XP_011510018.1|//PREDICTED: tensin-1 isoform X6 [Homo sapiens];gi|767919472|ref|XP_011510023.1|//PREDICTED: tensin-1 isoform X11 [Homo sapiens];gi|931567399|ref|XP_014199568.1|//PREDICTED: tensin-1 isoform X3 [Pan paniscus];gi|767919457|ref|XP_011510016.1|//PREDICTED: tensin-1 isoform X4 [Homo sapiens];gi|767919484|ref|XP_011510029.1|//PREDICTED: tensin-1 isoform X15 [Homo sapiens];gi|62088056|dbj|BAD92475.1|//tensin variant [Homo sapiens];gi|767919478|ref|XP_011510026.1|//PREDICTED: tensin-1 isoform X12 [Homo sapiens]"]
[56967,7313,1.31,0.49,-1.41871315742224,2.35876409508197e-5,"Down",3.55534e-6,"C14orf132","GO:0031224//intrinsic component of membrane","NA","NA","K01064//wingless-type MMTV integration site family, member 9;K12025//tripartite motif-containing protein 52","gi|426377963|ref|XP_004055719.1|//PREDICTED: uncharacterized protein LOC101137545 [Gorilla gorilla gorilla];gi|119602033|gb|EAW81627.1|//hCG1785399, isoform CRA_a [Homo sapiens]"]
[1852,2386,9.03,3.38,-1.41770274119867,1.9006971408867e-10,"Down",1.430102e-11,"DUSP9","GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part","GO:0008138//protein tyrosine/serine/threonine phosphatase activity","GO:0000165//MAPK cascade;GO:0006464//cellular protein modification process","K18498//dual specificity phosphatase 9 [EC:3.1.3.16 3.1.3.48]","gi|768039803|ref|XP_011529425.1|//PREDICTED: dual specificity protein phosphatase 9 isoform X2 [Homo sapiens]"]
[7077,3670,11.03,4.13,-1.41721910417194,6.921648e-19,"Down",2.68092e-20,"TIMP2","GO:0043231//intracellular membrane-bounded organelle;GO:0042995//cell projection;GO:0044297//cell body;GO:0030427//site of polarized growth;GO:0005578//proteinaceous extracellular matrix","GO:0043169//cation binding;GO:0070011//peptidase activity, acting on L-amino acid peptides;GO:0004866//endopeptidase inhibitor activity;GO:0005102//receptor binding","GO:0010466//negative regulation of peptidase activity;GO:0007346//regulation of mitotic cell cycle;GO:0048232//male gamete generation;GO:0046058//cAMP metabolic process;GO:0031281//positive regulation of cyclase activity;GO:0046578//regulation of Ras protein signal transduction;GO:0008283//cell proliferation;GO:0030162//regulation of proteolysis;GO:0010033//response to organic substance;GO:0045597//positive regulation of cell differentiation;GO:0032486//Rap protein signal transduction;GO:0050767//regulation of neurogenesis","K16866//metalloproteinase inhibitor 3","gi|1517893|gb|AAC50729.1|//tissue inhibitor of metalloproteinases-2 [Homo sapiens]"]
[2261,4306,8.42,3.16,-1.41389567488929,5.42386794936709e-17,"Down",2.38224e-18,"FGFR3","GO:0044421//extracellular region part;GO:0044459//plasma membrane part;GO:0016021//integral component of membrane;GO:0045202//synapse;GO:0000323//lytic vacuole","GO:0005515//protein binding;GO:0032559//adenyl ribonucleotide binding;GO:0005539//glycosaminoglycan binding;GO:0019838//growth factor binding;GO:0004714//transmembrane receptor protein tyrosine kinase activity","GO:0060602//branch elongation of an epithelium;GO:0008589//regulation of smoothened signaling pathway;GO:0007420//brain development;GO:0030323//respiratory tube development;GO:0043009//chordate embryonic development;GO:0021761//limbic system development;GO:0008543//fibroblast growth factor receptor signaling pathway;GO:0008285//negative regulation of cell proliferation;GO:0060688//regulation of morphogenesis of a branching structure;GO:0048729//tissue morphogenesis;GO:0048667//cell morphogenesis involved in neuron differentiation;GO:0003151//outflow tract morphogenesis;GO:0006915//apoptotic process;GO:0035264//multicellular organism growth;GO:0060442//branching involved in prostate gland morphogenesis;GO:0048646//anatomical structure formation involved in morphogenesis;GO:0051726//regulation of cell cycle;GO:0051147//regulation of muscle cell differentiation;GO:0045595//regulation of cell differentiation;GO:0045926//negative regulation of growth;GO:0035272//exocrine system development;GO:0021859//pyramidal neuron differentiation;GO:0016567//protein ubiquitination;GO:0001503//ossification;GO:0042490//mechanoreceptor differentiation;GO:0055008//cardiac muscle tissue morphogenesis;GO:0000122//negative regulation of transcription from RNA polymerase II promoter;GO:0001934//positive regulation of protein phosphorylation;GO:0002067//glandular epithelial cell differentiation;GO:0010463//mesenchymal cell proliferation;GO:0060348//bone development;GO:0045165//cell fate commitment;GO:0021869//forebrain ventricular zone progenitor cell division;GO:0042471//ear morphogenesis;GO:0030177//positive regulation of Wnt signaling pathway;GO:0043410//positive regulation of MAPK cascade;GO:0001942//hair follicle development;GO:0050679//positive regulation of epithelial cell proliferation;GO:0048762//mesenchymal cell differentiation","K05095//fibroblast growth factor receptor 4 [EC:2.7.10.1];K05094//fibroblast growth factor receptor 3 [EC:2.7.10.1]","gi|578808124|ref|XP_006713933.1|//PREDICTED: fibroblast growth factor receptor 3 isoform X3 [Homo sapiens];gi|578808122|ref|XP_006713932.1|//PREDICTED: fibroblast growth factor receptor 3 isoform X2 [Homo sapiens];gi|13112048|ref|NP_075254.1|//fibroblast growth factor receptor 3 isoform 2 precursor [Homo sapiens];gi|578808126|ref|XP_006713934.1|//PREDICTED: fibroblast growth factor receptor 3 isoform X4 [Homo sapiens];gi|578808120|ref|XP_006713931.1|//PREDICTED: fibroblast growth factor receptor 3 isoform X1 [Homo sapiens];gi|608785275|gb|AHW56474.1|//fibroblast growth factor receptor 3 isoform A, partial [Homo sapiens];gi|767929030|ref|XP_011511722.1|//PREDICTED: fibroblast growth factor receptor 3 isoform X5 [Homo sapiens];gi|578808130|ref|XP_006713936.1|//PREDICTED: fibroblast growth factor receptor 3 isoform X7 [Homo sapiens];gi|4503711|ref|NP_000133.1|//fibroblast growth factor receptor 3 isoform 1 precursor [Homo sapiens];gi|767929032|ref|XP_011511724.1|//PREDICTED: fibroblast growth factor receptor 3 isoform X8 [Homo sapiens];gi|254028242|ref|NP_001156685.1|//fibroblast growth factor receptor 3 isoform 3 precursor [Homo sapiens]"]
[22979,7488,0.93,0.35,-1.40987579416307,0.000535902928571429,"Down",0.000105671,"EFR3B","NA","NA","NA","K17776//metaxin;K11447//histone demethylase [EC:1.14.11.-];K01064//wingless-type MMTV integration site family, member 9","gi|190684710|ref|NP_055786.1|//protein EFR3 homolog B isoform 1 [Homo sapiens];gi|767914180|ref|XP_011531003.1|//PREDICTED: protein EFR3 homolog B isoform X1 [Homo sapiens];gi|795106706|ref|XP_011806467.1|//PREDICTED: protein EFR3 homolog B [Colobus angolensis palliatus];gi|4589550|dbj|BAA76797.1|//KIAA0953 protein [Homo sapiens]"]
[1687,2294,8.18,3.09,-1.40449400503737,1.23218406641735e-9,"Down",1.017686e-10,"DFNA5","NA","NA","GO:0050954//sensory perception of mechanical stimulus","K20917//gasdermin-D","gi|4758154|ref|NP_004394.1|//non-syndromic hearing impairment protein 5 isoform a [Homo sapiens];gi|133778010|gb|AAI25067.1|//DFNA5 protein, partial [Homo sapiens]"]
[5333,2941,2.46,0.93,-1.40335569423121,0.000747112734565283,"Down",0.0001523486,"PLCD1","GO:0044424//intracellular part","GO:0046872//metal ion binding;GO:0005515//protein binding;GO:0060089//molecular transducer activity;GO:0004629//phospholipase C activity","GO:0019637//organophosphate metabolic process;GO:0007165//signal transduction;GO:0006629//lipid metabolic process","K05857//phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]","gi|195972883|ref|NP_001124436.1|//1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform 1 [Homo sapiens] ;gi|635083261|ref|XP_007969956.1|//PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [Chlorocebus sabaeus]"]
[54961,2894,6.76,2.56,-1.40087943628218,2.57975117596567e-9,"Down",2.22788e-10,"SSH3","GO:0043231//intracellular membrane-bounded organelle;GO:0043232//intracellular non-membrane-bounded organelle","GO:0004721//phosphoprotein phosphatase activity;GO:0008092//cytoskeletal protein binding","GO:0030032//lamellipodium assembly;GO:0006464//cellular protein modification process;GO:0010769//regulation of cell morphogenesis involved in differentiation;GO:0030832//regulation of actin filament length","K05766//protein phosphatase slingshot [EC:3.1.3.16 3.1.3.48]","gi|239582767|ref|NP_060327.3|//protein phosphatase Slingshot homolog 3 [Homo sapiens];gi|966983729|ref|XP_014969011.1|//PREDICTED: protein phosphatase Slingshot homolog 3 isoform X2 [Macaca mulatta]"]
[5515,2643,78.17,29.64,-1.39906959012796,1.02047312454545e-92,"Down",5.54742e-95,"PPP2CA","GO:0016020//membrane;GO:0008287//protein serine/threonine phosphatase complex;GO:0043231//intracellular membrane-bounded organelle;GO:0005819//spindle;GO:0044444//cytoplasmic part;GO:0044427//chromosomal part","GO:0043169//cation binding;GO:0004721//phosphoprotein phosphatase activity;GO:0046983//protein dimerization activity","GO:0006396//RNA processing;GO:0022403//cell cycle phase;GO:0046519//sphingoid metabolic process;GO:0006260//DNA replication;GO:0042503//tyrosine phosphorylation of Stat3 protein;GO:0016049//cell growth;GO:0000302//response to reactive oxygen species;GO:0009894//regulation of catabolic process;GO:0006511//ubiquitin-dependent protein catabolic process;GO:0045860//positive regulation of protein kinase activity;GO:0001837//epithelial to mesenchymal transition;GO:0012502//induction of programmed cell death;GO:0051291//protein heterooligomerization;GO:0000165//MAPK cascade;GO:0006915//apoptotic process;GO:0007155//cell adhesion;GO:0016055//Wnt signaling pathway;GO:0009966//regulation of signal transduction;GO:0050793//regulation of developmental process","K04382//serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]","gi|491668487|pdb|4I5L|C//Chain C, Structural Mechanism Of Trimeric Pp2a Holoenzyme Involving Pr70: Insight For Cdc6 Dephosphorylation"]
[84220,7182,7.24,2.76,-1.39132143030504,5.97397818893617e-25,"Down",1.734476e-26,"RGPD5","GO:0005635//nuclear envelope","GO:0017016//Ras GTPase binding","GO:0006810//transport","K12172//E3 SUMO-protein ligase RanBP2","gi|83267877|ref|NP_005045.2|//RANBP2-like and GRIP domain-containing protein 5/6 isoform 1 [Homo sapiens];gi|767920084|ref|XP_006712857.2|//PREDICTED: RANBP2-like and GRIP domain-containing protein 5/6 isoform X4 [Homo sapiens];gi|14149991|ref|NP_115636.1|//RANBP2-like and GRIP domain-containing protein 5/6 isoform 2 [Homo sapiens];gi|767920090|ref|XP_011510278.1|//PREDICTED: RANBP2-like and GRIP domain-containing protein 5/6 isoform X7 [Homo sapiens]"]
[653689,1108,15.13,5.77,-1.39076876357125,4.27353299082569e-8,"Down",4.3163e-9,"GSTT2B","GO:0044424//intracellular part","GO:0016765//transferase activity, transferring alkyl or aryl (other than methyl) groups","NA","K00799//glutathione S-transferase [EC:2.5.1.18]","gi|124249394|ref|NP_001074312.1|//glutathione S-transferase theta-2B [Homo sapiens];gi|47678279|emb|CAG30260.1|//Em:AP000351.3 [Homo sapiens]"]
[10082,6772,1.02,0.39,-1.38702312310925,0.000565994004485981,"Down",0.0001122338,"GPC6","GO:0031012//extracellular matrix;GO:0016021//integral component of membrane","GO:0043394//proteoglycan binding","NA","K08112//glypican 6","gi|5031719|ref|NP_005699.1|//glypican-6 precursor [Homo sapiens];gi|931585719|ref|XP_014202977.1|//PREDICTED: glypican-6 isoform X2 [Pan paniscus]"]
[643699,5329,1.49,0.57,-1.38627850629742,0.000318977984528926,"Down",5.96064e-5,"GOLGA8N","NA","NA","NA","K20358//golgin subfamily A member 2","gi|542133086|ref|NP_001269423.1|//golgin A8 family, member N [Homo sapiens]"]
[7869,2663,3.45,1.32,-1.38605843230708,0.000107108381927974,"Down",1.818884e-5,"SEMA3B","GO:0043231//intracellular membrane-bounded organelle","GO:0004871//signal transducer activity","GO:0007154//cell communication;GO:0032501//multicellular organismal process;GO:0006935//chemotaxis","K06840//semaphorin 3","gi|27882566|gb|AAH44602.1|//SEMA3B protein, partial [Homo sapiens];gi|54607089|ref|NP_001005914.1|//semaphorin-3B isoform 2 precursor [Homo sapiens];gi|586798182|ref|NP_001276990.1|//semaphorin-3B isoform 3 precursor [Homo sapiens];gi|2880035|gb|AAC02731.1|//semaphorin V [Homo sapiens];gi|4759092|ref|NP_004627.1|//semaphorin-3B isoform 1 precursor [Homo sapiens]"]
[55222,3018,3.76,1.44,-1.38466385023533,1.05081797843478e-5,"Down",1.493008e-6,"LRRC20","NA","NA","NA","K04240//neuropeptide FF receptor 1;K16175//protein scribble;K04309//leucine-rich repeat-containing G protein-coupled receptor 4;K10641//E3 ubiquitin-protein ligase LRSAM1 [EC:2.3.2.27];K16340//PH domain and leucine-rich repeat-containing protein phosphatase [EC:3.1.3.16];K06850//slit 3","gi|7023132|dbj|BAA91849.1|//unnamed protein product [Homo sapiens];gi|46397369|ref|NP_997002.1|//leucine-rich repeat-containing protein 20 isoform 1 [Homo sapiens];gi|545193937|ref|XP_001503777.2|//PREDICTED: leucine-rich repeat-containing protein 20 isoform X1 [Equus caballus];gi|970735182|ref|XP_015102186.1|//PREDICTED: leucine-rich repeat-containing protein 20 isoform X2 [Vicugna pacos];gi|8922644|ref|NP_060675.1|//leucine-rich repeat-containing protein 20 isoform 3 [Homo sapiens]"]
[7336,1681,55.94,21.45,-1.38290260608928,1.84099485755396e-38,"Down",3.16158e-40,"UBE2V2","GO:0031371//ubiquitin conjugating enzyme complex;GO:0043231//intracellular membrane-bounded organelle","GO:0016879//ligase activity, forming carbon-nitrogen bonds;GO:0005488//binding","GO:0006281//DNA repair;GO:0000738//DNA catabolic process, exonucleolytic;GO:0016567//protein ubiquitination","K10704//ubiquitin-conjugating enzyme E2 variant","gi|521032401|gb|EPQ14187.1|//Ubiquitin-conjugating enzyme E2 variant 2 [Myotis brandtii];gi|830017448|ref|XP_004679948.2|//PREDICTED: ubiquitin-conjugating enzyme E2 variant 2 isoform X1 [Condylura cristata];gi|671028198|ref|XP_008704899.1|//PREDICTED: ubiquitin-conjugating enzyme E2 variant 2 [Ursus maritimus];gi|767951911|ref|XP_011515885.1|//PREDICTED: ubiquitin-conjugating enzyme E2 variant 2 isoform X1 [Homo sapiens]"]
[84962,4031,61.05,23.5,-1.3773305384224,1.23374312625e-116,"Down",4.87766e-119,"AJUBA","GO:0043231//intracellular membrane-bounded organelle;GO:0005856//cytoskeleton;GO:0015630//microtubule cytoskeleton;GO:0030529//intracellular ribonucleoprotein complex;GO:0030054//cell junction","GO:0046872//metal ion binding;GO:0005515//protein binding;GO:0046914//transition metal ion binding","GO:0035194//posttranscriptional gene silencing by RNA;GO:0006461//protein complex assembly","K16682//LIM domain-containing protein","gi|574273432|ref|NP_001276026.1|//LIM domain-containing protein ajuba isoform 3 [Homo sapiens] ;gi|14249622|ref|NP_116265.1|//LIM domain-containing protein ajuba isoform 1 [Homo sapiens];gi|335310594|ref|XP_003362104.1|//PREDICTED: LIM domain-containing protein ajuba [Sus scrofa]"]
[55809,7906,0.83,0.32,-1.37503943134692,0.000407760397166774,"Down",7.82372e-5,"TRERF1","GO:0043231//intracellular membrane-bounded organelle","GO:0003677//DNA binding;GO:0046872//metal ion binding;GO:0003713//transcription coactivator activity;GO:0005515//protein binding;GO:0001071//nucleic acid binding transcription factor activity","GO:0008202//steroid metabolic process;GO:0008203//cholesterol metabolic process;GO:0065008//regulation of biological quality;GO:0006355//regulation of transcription, DNA-templated;GO:0032501//multicellular organismal process","K11829//REST corepressor 1;K11584//serine/threonine-protein phosphatase 2A regulatory subunit B'","gi|662033858|ref|NP_001284502.1|//transcriptional-regulating factor 1 isoform 1 [Homo sapiens];gi|767940349|ref|XP_011513043.1|//PREDICTED: transcriptional-regulating factor 1 isoform X3 [Homo sapiens];gi|15812226|ref|NP_277037.1|//transcriptional-regulating factor 1 isoform 2 [Homo sapiens];gi|767940365|ref|XP_011513051.1|//PREDICTED: transcriptional-regulating factor 1 isoform X7 [Homo sapiens];gi|767940363|ref|XP_011513050.1|//PREDICTED: transcriptional-regulating factor 1 isoform X6 [Homo sapiens];gi|767940359|ref|XP_011513048.1|//PREDICTED: transcriptional-regulating factor 1 isoform X4 [Homo sapiens];gi|578811809|ref|XP_006715211.1|//PREDICTED: transcriptional-regulating factor 1 isoform X11 [Homo sapiens] ;gi|767940370|ref|XP_011513053.1|//PREDICTED: transcriptional-regulating factor 1 isoform X8 [Homo sapiens];gi|767940361|ref|XP_011513049.1|//PREDICTED: transcriptional-regulating factor 1 isoform X5 [Homo sapiens];gi|578811807|ref|XP_006715210.1|//PREDICTED: transcriptional-regulating factor 1 isoform X10 [Homo sapiens];gi|767940372|ref|XP_011513054.1|//PREDICTED: transcriptional-regulating factor 1 isoform X9 [Homo sapiens]"]
[254887,4414,2.74,1.06,-1.37011162839733,1.82411083487579e-6,"Down",2.31338e-7,"ZDHHC23","GO:0031224//intrinsic component of membrane","GO:0046914//transition metal ion binding;GO:0016747//transferase activity, transferring acyl groups other than amino-acyl groups","NA","K18932//palmitoyltransferase [EC:2.3.1.225]","gi|767926212|ref|XP_011510921.1|//PREDICTED: palmitoyltransferase ZDHHC23 isoform X5 [Homo sapiens];gi|530374237|ref|XP_005247327.1|//PREDICTED: palmitoyltransferase ZDHHC23 isoform X7 [Homo sapiens];gi|578807217|ref|XP_006713625.1|//PREDICTED: palmitoyltransferase ZDHHC23 isoform X4 [Homo sapiens];gi|1001184374|ref|NP_001307397.1|//palmitoyltransferase ZDHHC23 isoform b [Homo sapiens];gi|50234886|ref|NP_775841.2|//palmitoyltransferase ZDHHC23 isoform c [Homo sapiens];gi|1001184361|ref|NP_001307396.1|//palmitoyltransferase ZDHHC23 isoform a [Homo sapiens] "]
[8359,372,422.17,163.33,-1.37003425691787,1.26361888708861e-62,"Down",1.233332e-64,"HIST1H4A","GO:0043231//intracellular membrane-bounded organelle;GO:0000785//chromatin","NA","GO:0034728//nucleosome organization","K11253//histone H3;K11254//histone H4","gi|953881761|ref|XP_014590042.1|//PREDICTED: histone H4 [Equus caballus]"]
[3398,1402,8.69,3.37,-1.36660758563254,8.10094899512195e-6,"Down",1.128468e-6,"ID2","GO:0032991//macromolecular complex;GO:0031981//nuclear lumen;GO:0044444//cytoplasmic part;GO:0044427//chromosomal part","GO:0005488//binding","GO:0048537//mucosal-associated lymphoid tissue development;GO:0021700//developmental maturation;GO:0001822//kidney development;GO:0010226//response to lithium ion;GO:0048546//digestive tract morphogenesis;GO:0021988//olfactory lobe development;GO:0045686//negative regulation of glial cell differentiation;GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0002763//positive regulation of myeloid leukocyte differentiation;GO:0010033//response to organic substance;GO:0003164//His-Purkinje system development;GO:0008285//negative regulation of cell proliferation;GO:0050673//epithelial cell proliferation;GO:0045165//cell fate commitment;GO:0009605//response to external stimulus;GO:0045577//regulation of B cell differentiation;GO:0045687//positive regulation of glial cell differentiation;GO:0048562//embryonic organ morphogenesis;GO:0030218//erythrocyte differentiation;GO:0021782//glial cell development;GO:0043392//negative regulation of DNA binding;GO:0060644//mammary gland epithelial cell differentiation;GO:0051726//regulation of cell cycle;GO:0006629//lipid metabolic process","K17693//DNA-binding protein inhibitor ID2","gi|724904319|ref|XP_010377995.1|//PREDICTED: DNA-binding protein inhibitor ID-2 [Rhinopithecus roxellana]"]
[3397,1012,192.08,74.54,-1.36562058450157,2.96090264235294e-81,"Down",1.865654e-83,"ID1","GO:0043231//intracellular membrane-bounded organelle","GO:0005488//binding","GO:0043392//negative regulation of DNA binding;GO:0043542//endothelial cell migration;GO:0034613//cellular protein localization;GO:0007178//transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0032501//multicellular organismal process;GO:0048646//anatomical structure formation involved in morphogenesis","K04680//DNA-binding protein inhibitor ID1","gi|675655701|ref|XP_008993830.1|//PREDICTED: DNA-binding protein inhibitor ID-1 isoform X1 [Callithrix jacchus];gi|795112865|ref|XP_011815516.1|//PREDICTED: DNA-binding protein inhibitor ID-1 [Colobus angolensis palliatus]"]
[81575,4752,3.19,1.24,-1.36321630337799,4.66784532628239e-7,"Down",5.45274e-8,"APOLD1","NA","NA","GO:0007275//multicellular organism development;GO:0009987//cellular process","K12581//CCR4-NOT transcription complex subunit 7/8;K14777//ATP-dependent RNA helicase DDX47/RRP3 [EC:3.6.4.13];K14480//apolipoprotein L","gi|27503692|gb|AAH42478.1|//APOLD1 protein, partial [Homo sapiens];gi|194353993|ref|NP_110444.3|//apolipoprotein L domain-containing protein 1 isoform 2 [Homo sapiens]"]
[147912,3352,4.15,1.62,-1.35711752334966,1.47373976603774e-6,"Down",1.833526e-7,"SIX5","GO:0044424//intracellular part","GO:0005488//binding","GO:0032502//developmental process;GO:0032501//multicellular organismal process;GO:0009987//cellular process","K19474//homeobox protein SIX5","gi|40354216|ref|NP_787071.2|//homeobox protein SIX5 [Homo sapiens]"]
[389136,7344,5.53,2.16,-1.35624816807124,7.62915475993641e-19,"Down",2.96438e-20,"VGLL3","GO:0043231//intracellular membrane-bounded organelle","NA","GO:0010467//gene expression","K06245//laminin, beta 4;K12581//CCR4-NOT transcription complex subunit 7/8;K15289//solute carrier family 35, member F5;K17985//activating molecule in BECN1-regulated autophagy protein 1","gi|675797566|ref|XP_008955109.1|//PREDICTED: transcription cofactor vestigial-like protein 3 isoform X1 [Pan paniscus];gi|1001184386|ref|NP_001307423.1|//transcription cofactor vestigial-like protein 3 isoform 3 [Homo sapiens];gi|56550035|ref|NP_057290.2|//transcription cofactor vestigial-like protein 3 isoform 1 [Homo sapiens];gi|578806060|ref|XP_006713201.1|//PREDICTED: transcription cofactor vestigial-like protein 3 isoform X1 [Homo sapiens]"]
[4147,3693,26.06,10.19,-1.35468303240232,5.53262917272727e-40,"Down",9.02282e-42,"MATN2","GO:0031012//extracellular matrix","GO:0046872//metal ion binding","NA","K19467//matrilin-3","gi|960139588|ref|NP_001304677.1|//matrilin-2 isoform c precursor [Homo sapiens];gi|530389024|ref|XP_005250977.1|//PREDICTED: matrilin-2 isoform X2 [Homo sapiens];gi|21739491|emb|CAD38787.1|//hypothetical protein [Homo sapiens]"]
[8706,3485,3.4,1.33,-1.35410850063651,7.3665215950668e-7,"Down",8.85548e-8,"B3GALNT1","GO:0031224//intrinsic component of membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0012505//endomembrane system","GO:0035250//UDP-galactosyltransferase activity;GO:0008376//acetylgalactosaminyltransferase activity","GO:0006464//cellular protein modification process;GO:0009311//oligosaccharide metabolic process","K00719//galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase [EC:2.4.1.79]","gi|119599028|gb|EAW78622.1|//UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 3 (Globoside blood group), isoform CRA_b [Homo sapiens];gi|817356525|ref|XP_012302797.1|//PREDICTED: UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 isoform X2 [Aotus nancymaae];gi|694904952|ref|XP_009445048.1|//PREDICTED: uncharacterized protein LOC104005832 [Pan troglodytes];gi|817356520|ref|XP_012302795.1|//PREDICTED: UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 1 isoform X1 [Aotus nancymaae]"]
[60529,5466,2.53,0.99,-1.3536369546147,1.47447187719821e-6,"Down",1.833526e-7,"ALX4","NA","NA","NA","K09451//homeobox protein aristaless-like 4","NA"]
[7473,3385,10.28,4.03,-1.35098852066591,2.89279154285714e-15,"Down",1.426024e-16,"WNT3","GO:0031012//extracellular matrix;GO:0005768//endosome;GO:0044425//membrane part","GO:0001664//G-protein coupled receptor binding;GO:0060089//molecular transducer activity","GO:0035567//non-canonical Wnt signaling pathway;GO:0060429//epithelium development;GO:0001704//formation of primary germ layer;GO:0032526//response to retinoic acid;GO:0007420//brain development;GO:0030326//embryonic limb morphogenesis;GO:0000122//negative regulation of transcription from RNA polymerase II promoter;GO:0042471//ear morphogenesis;GO:0060070//canonical Wnt signaling pathway;GO:0008283//cell proliferation;GO:0009798//axis specification;GO:0030517//negative regulation of axon extension;GO:0006935//chemotaxis;GO:0048672//positive regulation of collateral sprouting;GO:0060061//Spemann organizer formation","K00312//wingless-type MMTV integration site family, member 3","gi|803290661|ref|XP_012004993.1|//PREDICTED: proto-oncogene Wnt-3 isoform X2 [Ovis aries musimon]"]
[414328,1784,5.39,2.12,-1.34622100818931,1.7585508371134e-8,"Down",1.685984e-9,"IDNK","GO:0044424//intracellular part","GO:0032559//adenyl ribonucleotide binding;GO:0016301//kinase activity","GO:0044238//primary metabolic process","K00851//gluconokinase [EC:2.7.1.12]","gi|148744483|gb|AAI42992.1|//C9orf103 protein [Homo sapiens];gi|578817474|ref|XP_006717174.1|//PREDICTED: probable gluconokinase isoform X2 [Homo sapiens];gi|829840489|ref|XP_012635282.1|//PREDICTED: probable gluconokinase isoform X1 [Microcebus murinus];gi|931576264|ref|XP_014201655.1|//PREDICTED: probable gluconokinase isoform X3 [Pan paniscus];gi|299758445|ref|NP_001001551.2|//probable gluconokinase isoform 1 [Homo sapiens]"]
[9481,2096,5.63,2.23,-1.33609121215992,9.4614273995585e-5,"Down",1.588594e-5,"SLC25A27","GO:0043231//intracellular membrane-bounded organelle;GO:0031224//intrinsic component of membrane;GO:0019866//organelle inner membrane","NA","GO:0044237//cellular metabolic process;GO:0051234//establishment of localization","K15112//solute carrier family 25 (mitochondrial uncoupling protein), member 27","gi|530382802|ref|XP_005249540.1|//PREDICTED: mitochondrial uncoupling protein 4 isoform X1 [Homo sapiens];gi|675802062|ref|XP_008956932.1|//PREDICTED: mitochondrial uncoupling protein 4 isoform X1 [Pan paniscus];gi|837817245|ref|XP_012783911.1|//PREDICTED: mitochondrial uncoupling protein 4 isoform X2 [Ochotona princeps];gi|108860679|ref|NP_004268.3|//mitochondrial uncoupling protein 4 isoform 1 [Homo sapiens];gi|990035120|ref|XP_015455846.1|//PREDICTED: mitochondrial uncoupling protein 4 isoform X1 [Pteropus alecto]"]
[84904,2269,10.92,4.33,-1.33453392619313,1.09858354615385e-6,"Down",1.340994e-7,"ARHGEF39","GO:0044464//cell part","GO:0005088//Ras guanyl-nucleotide exchange factor activity;GO:0005085//guanyl-nucleotide exchange factor activity","GO:0007266//Rho protein signal transduction","K20688//Rho guanine nucleotide exchange factor 16;K12581//CCR4-NOT transcription complex subunit 7/8;K17776//metaxin;K15696//RING finger protein 113B;K17985//activating molecule in BECN1-regulated autophagy protein 1;K20045//intersectin;K18443//golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1;K01064//wingless-type MMTV integration site family, member 9","gi|694929865|ref|XP_009454854.1|//PREDICTED: rho guanine nucleotide exchange factor 39 isoform X10 [Pan troglodytes];gi|593724980|ref|XP_007108607.1|//PREDICTED: rho guanine nucleotide exchange factor 39 isoform X1 [Physeter catodon];gi|694929844|ref|XP_009454843.1|//PREDICTED: rho guanine nucleotide exchange factor 39 isoform X1 [Pan troglodytes];gi|767955353|ref|XP_011516359.1|//PREDICTED: rho guanine nucleotide exchange factor 39 isoform X1 [Homo sapiens];gi|694929867|ref|XP_009454855.1|//PREDICTED: rho guanine nucleotide exchange factor 39 isoform X11 [Pan troglodytes];gi|37702812|gb|AAR01010.1|//VAV-like protein [Homo sapiens];gi|90652857|ref|NP_116207.2|//rho guanine nucleotide exchange factor 39 [Homo sapiens];gi|694929859|ref|XP_009454851.1|//PREDICTED: rho guanine nucleotide exchange factor 39 isoform X7 [Pan troglodytes]"]
[57577,4296,1.79,0.71,-1.33406865775957,0.000227946862040816,"Down",4.13988e-5,"CCDC191","NA","NA","NA","NA","gi|767927313|ref|XP_011511353.1|//PREDICTED: coiled-coil domain-containing protein KIAA1407 isoform X2 [Homo sapiens];gi|24308223|ref|NP_065868.1|//coiled-coil domain-containing protein 191 [Homo sapiens];gi|530375083|ref|XP_005247738.1|//PREDICTED: coiled-coil domain-containing protein KIAA1407 isoform X7 [Homo sapiens];gi|530375081|ref|XP_005247737.1|//PREDICTED: coiled-coil domain-containing protein KIAA1407 isoform X6 [Homo sapiens];gi|767927315|ref|XP_011511354.1|//PREDICTED: coiled-coil domain-containing protein KIAA1407 isoform X3 [Homo sapiens];gi|767927317|ref|XP_011511355.1|//PREDICTED: coiled-coil domain-containing protein KIAA1407 isoform X4 [Homo sapiens];gi|578807632|ref|XP_006713778.1|//PREDICTED: coiled-coil domain-containing protein KIAA1407 isoform X1 [Homo sapiens]"]
[51144,2550,32.94,13.1,-1.33027374330154,6.03989083185841e-33,"Down",1.26484e-34,"HSD17B12","GO:0043231//intracellular membrane-bounded organelle;GO:0031224//intrinsic component of membrane;GO:0044421//extracellular region part;GO:0031090//organelle membrane","GO:0005515//protein binding;GO:0005539//glycosaminoglycan binding;GO:0033764//steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor","GO:0008202//steroid metabolic process;GO:0035336//long-chain fatty-acyl-CoA metabolic process;GO:0006641//triglyceride metabolic process;GO:0010810//regulation of cell-substrate adhesion;GO:0043062//extracellular structure organization","K10251//17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase [EC:1.1.1.62 1.1.1.330]","gi|795608684|ref|XP_011917708.1|//PREDICTED: very-long-chain 3-oxoacyl-CoA reductase isoform X2 [Cercocebus atys];gi|7705855|ref|NP_057226.1|//very-long-chain 3-oxoacyl-CoA reductase [Homo sapiens]"]
[92922,2580,6.86,2.73,-1.32930762525296,2.75413966502463e-7,"Down",3.10836e-8,"CCDC102A","NA","NA","NA","K16759//coiled-coil domain-containing protein 102A","gi|226495417|ref|NP_149989.2|//coiled-coil domain-containing protein 102A [Homo sapiens]"]
[4232,2506,73.32,29.22,-1.32725060773639,3.929566e-77,"Down",2.7673e-79,"MEST","GO:0043231//intracellular membrane-bounded organelle;GO:0031224//intrinsic component of membrane;GO:0031090//organelle membrane","GO:0003824//catalytic activity;GO:0005488//binding","GO:0009888//tissue development","NA","gi|29294639|ref|NP_002393.2|//mesoderm-specific transcript homolog protein isoform a [Homo sapiens];gi|359806892|ref|NP_001240830.1|//mesoderm-specific transcript homolog protein isoform d precursor [Homo sapiens];gi|359806886|ref|NP_001240829.1|//mesoderm-specific transcript homolog protein isoform c [Homo sapiens] ;gi|655817881|ref|XP_008256412.1|//PREDICTED: mesoderm-specific transcript homolog protein isoform X1 [Oryctolagus cuniculus];gi|767947835|ref|XP_011514524.1|//PREDICTED: mesoderm-specific transcript homolog protein isoform X1 [Homo sapiens];gi|426357910|ref|XP_004046272.1|//PREDICTED: mesoderm-specific transcript homolog protein isoform 4 [Gorilla gorilla gorilla]"]
[5764,1558,10.59,4.23,-1.32397302087239,6.44907464596273e-7,"Down",7.69682e-8,"PTN","GO:0043231//intracellular membrane-bounded organelle;GO:0044421//extracellular region part","GO:0005539//glycosaminoglycan binding;GO:0005102//receptor binding;GO:0019212//phosphatase inhibitor activity","GO:0048522//positive regulation of cellular process;GO:0008283//cell proliferation;GO:0007611//learning or memory;GO:0007167//enzyme linked receptor protein signaling pathway;GO:0001503//ossification;GO:0048731//system development","K16642//pleiotrophin","gi|958690453|ref|XP_014694824.1|//PREDICTED: pleiotrophin, partial [Equus asinus];gi|953851560|ref|XP_014594832.1|//PREDICTED: pleiotrophin, partial [Equus caballus]"]
[84984,2181,8.4,3.36,-1.32192809488736,2.75504174179431e-7,"Down",3.11108e-8,"CEP19","NA","NA","NA","K16801//centrosomal protein CEP19","gi|671031563|ref|XP_008706588.1|//PREDICTED: centrosomal protein of 19 kDa isoform X1 [Ursus maritimus];gi|675726536|ref|XP_008979706.1|//PREDICTED: LOW QUALITY PROTEIN: centrosomal protein of 19 kDa [Callithrix jacchus]"]
[5577,3652,3.03,1.22,-1.31243664591006,3.44452152199762e-5,"Down",5.3685e-6,"PRKAR2B","GO:0043234//protein complex;GO:0044425//membrane part;GO:0044444//cytoplasmic part;GO:0019866//organelle inner membrane","GO:0005515//protein binding;GO:0019887//protein kinase regulator activity;GO:0016208//AMP binding","GO:0032147//activation of protein kinase activity;GO:0030073//insulin secretion;GO:0010863//positive regulation of phospholipase C activity;GO:0015980//energy derivation by oxidation of organic compounds;GO:0032787//monocarboxylic acid metabolic process;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0033762//response to glucagon;GO:0022402//cell cycle process;GO:0007599//hemostasis;GO:0007611//learning or memory;GO:0042044//fluid transport","K04739//cAMP-dependent protein kinase regulator","gi|767948255|ref|XP_011514700.1|//PREDICTED: cAMP-dependent protein kinase type II-beta regulatory subunit isoform X1 [Homo sapiens];gi|47132585|ref|NP_002727.2|//cAMP-dependent protein kinase type II-beta regulatory subunit [Homo sapiens]"]
[9409,1573,20.96,8.46,-1.3089091484175,2.16704044895739e-11,"Down",1.476554e-12,"PEX16","GO:0031231//intrinsic component of peroxisomal membrane","GO:0005515//protein binding","GO:0006625//protein targeting to peroxisome","K13335//peroxin-16","gi|767966835|ref|XP_011518776.1|//PREDICTED: peroxisomal biogenesis factor 16 isoform X1 [Homo sapiens];gi|724862442|ref|XP_010369352.1|//PREDICTED: peroxisomal biogenesis factor 16 isoform X3 [Rhinopithecus roxellana]"]
[7168,1794,150.54,60.93,-1.30492223111302,8.45947523076923e-105,"Down",4.0761e-107,"TPM1","GO:0005865//striated muscle thin filament;GO:0001726//ruffle;GO:0005884//actin filament;GO:0043232//intracellular non-membrane-bounded organelle;GO:0031674//I band;GO:0032432//actin filament bundle;GO:0005737//cytoplasm","GO:0003779//actin binding;GO:0008092//cytoskeletal protein binding;GO:0042802//identical protein binding;GO:0005198//structural molecule activity","GO:0001996//positive regulation of heart rate by epinephrine-norepinephrine;GO:0009611//response to wounding;GO:0031032//actomyosin structure organization;GO:0016477//cell migration;GO:0030030//cell projection organization;GO:0030835//negative regulation of actin filament depolymerization;GO:0043462//regulation of ATPase activity;GO:0043009//chordate embryonic development;GO:0055008//cardiac muscle tissue morphogenesis;GO:0000302//response to reactive oxygen species;GO:0006941//striated muscle contraction;GO:0032233//positive regulation of actin filament bundle assembly;GO:0060047//heart contraction;GO:0009790//embryo development;GO:0030155//regulation of cell adhesion","K09290//tropomyosin 3;K10373//tropomyosin 1;K10375//tropomyosin 4","gi|675685135|ref|XP_009003251.1|//PREDICTED: tropomyosin alpha-1 chain isoform X11 [Callithrix jacchus];gi|940744892|ref|XP_014315315.1|//PREDICTED: tropomyosin alpha-1 chain isoform X9 [Myotis lucifugus];gi|675788513|ref|XP_008951503.1|//PREDICTED: tropomyosin alpha-1 chain isoform X2 [Pan paniscus];gi|635135327|ref|XP_008014549.1|//PREDICTED: tropomyosin alpha-1 chain isoform X10 [Chlorocebus sabaeus];gi|675685116|ref|XP_009003248.1|//PREDICTED: tropomyosin alpha-1 chain isoform X6 [Callithrix jacchus];gi|675685105|ref|XP_003733938.2|//PREDICTED: tropomyosin alpha-1 chain isoform X3 [Callithrix jacchus];gi|119598039|gb|EAW77633.1|//tropomyosin 1 (alpha), isoform CRA_m [Homo sapiens];gi|62087662|dbj|BAD92278.1|//TPM1 protein variant [Homo sapiens];gi|675685131|ref|XP_009003250.1|//PREDICTED: tropomyosin alpha-1 chain isoform X10 [Callithrix jacchus];gi|635135344|ref|XP_008014558.1|//PREDICTED: tropomyosin alpha-1 chain isoform X18 [Chlorocebus sabaeus];gi|635135325|ref|XP_008014548.1|//PREDICTED: tropomyosin alpha-1 chain isoform X9 [Chlorocebus sabaeus];gi|675685109|ref|XP_009003247.1|//PREDICTED: tropomyosin alpha-1 chain isoform X4 [Callithrix jacchus];gi|675788511|ref|XP_008951502.1|//PREDICTED: tropomyosin alpha-1 chain isoform X1 [Pan paniscus];gi|635135323|ref|XP_008014547.1|//PREDICTED: tropomyosin alpha-1 chain isoform X8 [Chlorocebus sabaeus];gi|635135309|ref|XP_008014539.1|//PREDICTED: tropomyosin alpha-1 chain isoform X1 [Chlorocebus sabaeus];gi|675685099|ref|XP_002753250.2|//PREDICTED: tropomyosin alpha-1 chain isoform X1 [Callithrix jacchus];gi|530406414|ref|XP_005254708.1|//PREDICTED: tropomyosin alpha-1 chain isoform X11 [Homo sapiens];gi|675685124|ref|XP_003733937.2|//PREDICTED: tropomyosin alpha-1 chain isoform X8 [Callithrix jacchus];gi|635135311|ref|XP_008014540.1|//PREDICTED: tropomyosin alpha-1 chain isoform X2 [Chlorocebus sabaeus];gi|940744890|ref|XP_014315314.1|//PREDICTED: tropomyosin alpha-1 chain isoform X8 [Myotis lucifugus];gi|530406404|ref|XP_005254703.1|//PREDICTED: tropomyosin alpha-1 chain isoform X7 [Homo sapiens]"]
[53373,4329,2.64,1.07,-1.30292713295731,4.46253200741427e-6,"Down",5.94894e-7,"TPCN1","GO:0031224//intrinsic component of membrane;GO:0031090//organelle membrane;GO:0005764//lysosome","GO:0005261//cation channel activity","GO:0006810//transport","K16896//two pore calcium channel protein 1","gi|426374236|ref|XP_004053985.1|//PREDICTED: two pore calcium channel protein 1 isoform 2 [Gorilla gorilla gorilla];gi|795241302|ref|XP_011853308.1|//PREDICTED: two pore calcium channel protein 1 isoform X2 [Mandrillus leucophaeus];gi|119618452|gb|EAW98046.1|//two pore segment channel 1, isoform CRA_a [Homo sapiens];gi|29725622|ref|NP_060371.2|//two pore calcium channel protein 1 isoform 2 [Homo sapiens];gi|635068412|ref|XP_008003007.1|//PREDICTED: two pore calcium channel protein 1 isoform X2 [Chlorocebus sabaeus];gi|767974642|ref|XP_005253962.2|//PREDICTED: two pore calcium channel protein 1 isoform X5 [Homo sapiens];gi|859794894|ref|XP_012912012.1|//PREDICTED: two pore calcium channel protein 1 isoform X1 [Mustela putorius furo];gi|946732347|ref|XP_014396550.1|//PREDICTED: two pore calcium channel protein 1 isoform X4 [Myotis brandtii]"]
[55604,5413,4.43,1.8,-1.29930979222534,2.99411900080064e-10,"Down",2.31014e-11,"LRRC16A","GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part","NA","GO:0006082//organic acid metabolic process;GO:0007599//hemostasis","K20493//leucine-rich repeat-containing protein 16","gi|675773252|ref|XP_008975063.1|//PREDICTED: leucine-rich repeat-containing protein 16A isoform X4 [Pan paniscus];gi|694914875|ref|XP_009448888.1|//PREDICTED: leucine-rich repeat-containing protein 16A isoform X3 [Pan troglodytes];gi|694914879|ref|XP_009448890.1|//PREDICTED: leucine-rich repeat-containing protein 16A isoform X5 [Pan troglodytes];gi|675773249|ref|XP_008975062.1|//PREDICTED: leucine-rich repeat-containing protein 16A isoform X3 [Pan paniscus];gi|530382226|ref|XP_005249275.1|//PREDICTED: leucine-rich repeat-containing protein 16A isoform X1 [Homo sapiens];gi|694914873|ref|XP_009448887.1|//PREDICTED: leucine-rich repeat-containing protein 16A isoform X2 [Pan troglodytes];gi|767940340|ref|XP_011513039.1|//PREDICTED: leucine-rich repeat-containing protein 16A isoform X7 [Homo sapiens];gi|675773239|ref|XP_008975059.1|//PREDICTED: leucine-rich repeat-containing protein 16A isoform X1 [Pan paniscus];gi|291190781|ref|NP_060110.4|//leucine-rich repeat-containing protein 16A isoform 1 [Homo sapiens];gi|694914871|ref|XP_009448885.1|//PREDICTED: leucine-rich repeat-containing protein 16A isoform X1 [Pan troglodytes];gi|291190783|ref|NP_001167448.1|//leucine-rich repeat-containing protein 16A isoform 2 [Homo sapiens];gi|694914881|ref|XP_009448891.1|//PREDICTED: leucine-rich repeat-containing protein 16A isoform X6 [Pan troglodytes]"]
[10179,3749,9.85,4.01,-1.29652148788882,3.17081085842697e-15,"Down",1.568952e-16,"RBM7","NA","GO:0003676//nucleic acid binding","GO:0022403//cell cycle phase","K13188//RNA-binding protein 7","gi|9994185|ref|NP_057174.1|//RNA-binding protein 7 isoform b [Homo sapiens];gi|554506545|ref|NP_001272974.1|//RNA-binding protein 7 isoform a [Homo sapiens]"]
[9479,3234,8.84,3.64,-1.28010791919274,9.7997879330855e-12,"Down",6.51382e-13,"MAPK8IP1","GO:0030424//axon;GO:0043231//intracellular membrane-bounded organelle;GO:0042995//cell projection;GO:0030426//growth cone;GO:0044444//cytoplasmic part","GO:0032947//protein complex scaffold;GO:0019887//protein kinase regulator activity;GO:0008092//cytoskeletal protein binding;GO:0019901//protein kinase binding;GO:0016772//transferase activity, transferring phosphorus-containing groups","GO:0043409//negative regulation of MAPK cascade;GO:0006810//transport;GO:0043407//negative regulation of MAP kinase activity;GO:0043066//negative regulation of apoptotic process;GO:0006351//transcription, DNA-templated","K04434//mitogen-activated protein kinase 8 interacting protein 1","gi|4885433|ref|NP_005447.1|//C-Jun-amino-terminal kinase-interacting protein 1 [Homo sapiens];gi|530395993|ref|XP_005253283.1|//PREDICTED: C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [Homo sapiens]"]
[81621,2502,15.05,6.2,-1.27942336637283,2.29347161237994e-13,"Down",1.327516e-14,"KAZALD1","GO:0005578//proteinaceous extracellular matrix","GO:0019838//growth factor binding","GO:0032501//multicellular organismal process;GO:0016049//cell growth;GO:0043062//extracellular structure organization;GO:0048869//cellular developmental process","K06756//neuronal cell adhesion molecule;K12567//titin [EC:2.7.11.1];K08784//HtrA serine peptidase 1 [EC:3.4.21.-];K19574//obscurin-like protein 1;K17531//obscurin-RhoGEF [EC:2.7.11.1]","gi|635055726|ref|XP_007962075.1|//PREDICTED: uncharacterized protein LOC103216404 [Chlorocebus sabaeus];gi|985482517|ref|NP_001306232.1|//kazal-type serine protease inhibitor domain-containing protein 1 isoform b [Homo sapiens];gi|19923632|ref|NP_112191.2|//kazal-type serine protease inhibitor domain-containing protein 1 isoform a precursor [Homo sapiens];gi|47077908|dbj|BAD18818.1|//unnamed protein product [Homo sapiens]"]
[9837,3291,55.53,22.93,-1.27603104101094,1.59293433674419e-71,"Down",1.269388e-73,"GINS1","GO:0031981//nuclear lumen","NA","GO:0051320//S phase;GO:0006261//DNA-dependent DNA replication;GO:0001832//blastocyst growth","K10732//GINS complex subunit 1","gi|126116594|ref|NP_066545.3|//DNA replication complex GINS protein PSF1 [Homo sapiens];gi|795363910|ref|XP_011748063.1|//PREDICTED: DNA replication complex GINS protein PSF1 [Macaca nemestrina];gi|635022594|ref|XP_007961578.1|//PREDICTED: DNA replication complex GINS protein PSF1 isoform X1 [Chlorocebus sabaeus];gi|966967890|ref|XP_015005117.1|//PREDICTED: DNA replication complex GINS protein PSF1 [Macaca mulatta]"]
[10797,2185,83.3,34.51,-1.27130202181739,2.79882367769784e-70,"Down",2.40324e-72,"MTHFD2","GO:0043231//intracellular membrane-bounded organelle","GO:0004486//methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity;GO:0046872//metal ion binding;GO:0043168//anion binding;GO:0019238//cyclohydrolase activity","GO:0006760//folic acid-containing compound metabolic process","K13403//methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]","gi|635079855|ref|XP_007968376.1|//PREDICTED: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Chlorocebus sabaeus];gi|94721354|ref|NP_006627.2|//bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial precursor [Homo sapiens]"]
[4973,2533,83.36,34.56,-1.27025206011504,1.33434638732673e-81,"Down",8.32524e-84,"OLR1","GO:0016021//integral component of membrane","GO:0030246//carbohydrate binding;GO:0030169//low-density lipoprotein particle binding;GO:0004871//signal transducer activity","GO:0044260//cellular macromolecule metabolic process;GO:0002376//immune system process;GO:0016337//single organismal cell-cell adhesion;GO:0019538//protein metabolic process;GO:0006952//defense response;GO:0003013//circulatory system process;GO:0007599//hemostasis;GO:0000302//response to reactive oxygen species","K08763//oxidised low-density lipoprotein receptor 1","gi|4505501|ref|NP_002534.1|//oxidized low-density lipoprotein receptor 1 isoform 1 [Homo sapiens];gi|290654342|ref|NP_001166103.1|//oxidized low-density lipoprotein receptor 1 isoform 2 [Homo sapiens]"]
[6418,2941,317.06,131.59,-1.26870602220819,0,"Down",0,"SET","GO:0032991//macromolecular complex;GO:0031981//nuclear lumen;GO:0044444//cytoplasmic part","GO:0005515//protein binding;GO:0019212//phosphatase inhibitor activity;GO:0019888//protein phosphatase regulator activity","GO:0016070//RNA metabolic process;GO:0034728//nucleosome organization;GO:0051169//nuclear transport;GO:0016573//histone acetylation;GO:0043066//negative regulation of apoptotic process;GO:0006259//DNA metabolic process","K11290//template-activating factor I","gi|351721296|ref|NP_001234929.1|//protein SET isoform 3 [Homo sapiens];gi|145843637|gb|ABP96841.1|//SET [Homo sapiens];gi|402855248|ref|XP_003892243.1|//PREDICTED: protein SETSIP [Papio anubis];gi|861445584|ref|XP_012929021.1|//PREDICTED: protein SET isoform X2 [Heterocephalus glaber];gi|795074827|ref|XP_011843116.1|//PREDICTED: protein SET isoform X1 [Mandrillus leucophaeus]"]
[93664,4989,2.96,1.23,-1.26693886028971,4.75161460580913e-6,"Down",6.3666e-7,"CADPS2","GO:0012506//vesicle membrane;GO:0044459//plasma membrane part","GO:0043169//cation binding","GO:0006810//transport;GO:0016192//vesicle-mediated transport","K19933//calcium-dependent secretion activator","gi|530386642|ref|XP_005250758.1|//PREDICTED: calcium-dependent secretion activator 2 isoform X7 [Homo sapiens];gi|530386648|ref|XP_005250761.1|//PREDICTED: calcium-dependent secretion activator 2 isoform X10 [Homo sapiens];gi|530386652|ref|XP_005250763.1|//PREDICTED: calcium-dependent secretion activator 2 isoform X12 [Homo sapiens];gi|608785213|gb|AHW56443.1|//Ca++-dependent secretion activator 2 isoform B, partial [Homo sapiens];gi|530386632|ref|XP_005250753.1|//PREDICTED: calcium-dependent secretion activator 2 isoform X3 [Homo sapiens];gi|530386634|ref|XP_005250754.1|//PREDICTED: calcium-dependent secretion activator 2 isoform X2 [Homo sapiens];gi|608785215|gb|AHW56444.1|//Ca++-dependent secretion activator 2 isoform A, partial [Homo sapiens];gi|530386630|ref|XP_005250752.1|//PREDICTED: calcium-dependent secretion activator 2 isoform X1 [Homo sapiens];gi|269308219|ref|NP_001161412.1|//calcium-dependent secretion activator 2 isoform c [Homo sapiens];gi|767949064|ref|XP_011514998.1|//PREDICTED: calcium-dependent secretion activator 2 isoform X15 [Homo sapiens];gi|148839284|ref|NP_001009571.2|//calcium-dependent secretion activator 2 isoform b [Homo sapiens];gi|530386644|ref|XP_005250759.1|//PREDICTED: calcium-dependent secretion activator 2 isoform X8 [Homo sapiens];gi|530386638|ref|XP_005250756.1|//PREDICTED: calcium-dependent secretion activator 2 isoform X5 [Homo sapiens];gi|148839294|ref|NP_060424.9|//calcium-dependent secretion activator 2 isoform a [Homo sapiens];gi|530386654|ref|XP_005250764.1|//PREDICTED: calcium-dependent secretion activator 2 isoform X14 [Homo sapiens];gi|530386636|ref|XP_005250755.1|//PREDICTED: calcium-dependent secretion activator 2 isoform X4 [Homo sapiens];gi|767949066|ref|XP_011514999.1|//PREDICTED: calcium-dependent secretion activator 2 isoform X16 [Homo sapiens];gi|119603978|gb|EAW83572.1|//Ca2+-dependent activator protein for secretion 2, isoform CRA_b [Homo sapiens];gi|530386646|ref|XP_005250760.1|//PREDICTED: calcium-dependent secretion activator 2 isoform X9 [Homo sapiens];gi|530386640|ref|XP_005250757.1|//PREDICTED: calcium-dependent secretion activator 2 isoform X6 [Homo sapiens]"]
[79906,1448,6.64,2.76,-1.26651497456876,0.000421459463414634,"Down",8.1126e-5,"MORN1","NA","NA","NA","K19755//radial spoke head protein 1","gi|13376267|ref|NP_079124.1|//MORN repeat-containing protein 1 isoform 1 [Homo sapiens];gi|767906100|ref|XP_011540478.1|//PREDICTED: MORN repeat-containing protein 1 isoform X9 [Homo sapiens];gi|530360420|ref|XP_005244855.1|//PREDICTED: MORN repeat-containing protein 1 isoform X4 [Homo sapiens];gi|767906084|ref|XP_011540471.1|//PREDICTED: MORN repeat-containing protein 1 isoform X1 [Homo sapiens];gi|666666207|ref|NP_001287989.1|//MORN repeat-containing protein 1 isoform 2 [Homo sapiens];gi|767906086|ref|XP_011540472.1|//PREDICTED: MORN repeat-containing protein 1 isoform X2 [Homo sapiens];gi|767906092|ref|XP_011540474.1|//PREDICTED: MORN repeat-containing protein 1 isoform X5 [Homo sapiens];gi|767906096|ref|XP_011540476.1|//PREDICTED: MORN repeat-containing protein 1 isoform X7 [Homo sapiens];gi|795457973|ref|XP_011765564.1|//PREDICTED: MORN repeat-containing protein 1 isoform X4 [Macaca nemestrina];gi|767906094|ref|XP_011540475.1|//PREDICTED: MORN repeat-containing protein 1 isoform X6 [Homo sapiens]"]
[9475,7805,9.98,4.16,-1.26245628719617,7.13200555073314e-33,"Down",1.502356e-34,"ROCK2","GO:0016020//membrane;GO:0000922//spindle pole;GO:0044444//cytoplasmic part","GO:0043169//cation binding;GO:0032559//adenyl ribonucleotide binding;GO:0004672//protein kinase activity","GO:0006464//cellular protein modification process;GO:0007165//signal transduction;GO:0007010//cytoskeleton organization;GO:0010638//positive regulation of organelle organization;GO:0006935//chemotaxis","K17388//Rho-associated protein kinase 2 [EC:2.7.11.1]","gi|685580094|ref|XP_009181945.1|//PREDICTED: rho-associated protein kinase 2 isoform X1 [Papio anubis];gi|685580096|ref|XP_009181946.1|//PREDICTED: rho-associated protein kinase 2 isoform X2 [Papio anubis];gi|41872583|ref|NP_004841.2|//rho-associated protein kinase 2 [Homo sapiens];gi|530366978|ref|XP_005246247.1|//PREDICTED: rho-associated protein kinase 2 isoform X1 [Homo sapiens]"]
[55970,4444,45.71,19.09,-1.2596927162001,1.05783483777778e-78,"Down",7.05746e-81,"GNG12","GO:0031234//extrinsic component of cytoplasmic side of plasma membrane;GO:0015629//actin cytoskeleton","GO:0060089//molecular transducer activity;GO:0043168//anion binding","GO:0021543//pallium development;GO:0033762//response to glucagon;GO:0007267//cell-cell signaling;GO:0007166//cell surface receptor signaling pathway;GO:0002237//response to molecule of bacterial origin;GO:0015980//energy derivation by oxidation of organic compounds","K04347//guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12","gi|51036603|ref|NP_061329.3|//guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 precursor [Homo sapiens]"]
[3799,5894,57.97,24.24,-1.25791678680156,1.06362631384615e-131,"Down",3.41664e-134,"KIF5B","GO:0042995//cell projection;GO:0005875//microtubule associated complex;GO:0044444//cytoplasmic part","GO:0015631//tubulin binding;GO:0032559//adenyl ribonucleotide binding;GO:0003774//motor activity","GO:0007017//microtubule-based process;GO:0032988//ribonucleoprotein complex disassembly;GO:0051648//vesicle localization","K10396//kinesin family member 5","gi|4758648|ref|NP_004512.1|//kinesin-1 heavy chain [Homo sapiens]"]
[7059,3651,11.01,4.62,-1.25284971214831,2.5786135e-17,"Down",1.10867e-18,"THBS3","GO:0044444//cytoplasmic part","GO:0046872//metal ion binding;GO:0005539//glycosaminoglycan binding","GO:0060348//bone development;GO:0031589//cell-substrate adhesion;GO:0003416//endochondral bone growth;GO:0001503//ossification;GO:0048705//skeletal system morphogenesis;GO:0060343//trabecula formation","K04659//thrombospondin 2/3/4/5","gi|578801394|ref|XP_006711561.1|//PREDICTED: thrombospondin-3 isoform X2 [Homo sapiens];gi|767910292|ref|XP_011508229.1|//PREDICTED: thrombospondin-3 isoform X3 [Homo sapiens];gi|918654856|ref|XP_013363763.1|//PREDICTED: thrombospondin-3 isoform X2 [Chinchilla lanigera];gi|675741056|ref|XP_008968459.1|//PREDICTED: thrombospondin-3 isoform X2 [Pan paniscus];gi|332220647|ref|XP_003259467.1|//PREDICTED: thrombospondin-3 isoform X1 [Nomascus leucogenys];gi|767910300|ref|XP_011508233.1|//PREDICTED: thrombospondin-3 isoform X7 [Homo sapiens];gi|767910289|ref|XP_011508228.1|//PREDICTED: thrombospondin-3 isoform X1 [Homo sapiens];gi|767910298|ref|XP_011508232.1|//PREDICTED: thrombospondin-3 isoform X6 [Homo sapiens];gi|694889184|ref|XP_009431597.1|//PREDICTED: thrombospondin-3 isoform X8 [Pan troglodytes];gi|767910296|ref|XP_011508231.1|//PREDICTED: thrombospondin-3 isoform X5 [Homo sapiens];gi|357933594|ref|NP_001239536.1|//thrombospondin-3 isoform 2 precursor [Homo sapiens];gi|6005902|ref|NP_009043.1|//thrombospondin-3 isoform 1 precursor [Homo sapiens];gi|767910294|ref|XP_011508230.1|//PREDICTED: thrombospondin-3 isoform X4 [Homo sapiens];gi|357933596|ref|NP_001239537.1|//thrombospondin-3 isoform 3 precursor [Homo sapiens] "]
[112817,2149,7.64,3.21,-1.25099934091345,4.70336235036496e-8,"Down",4.77658e-9,"HOGA1","GO:0043231//intracellular membrane-bounded organelle","GO:0016832//aldehyde-lyase activity","NA","K18123//4-hydroxy-2-oxoglutarate aldolase [EC:4.1.3.16]","gi|31543060|ref|NP_612422.2|//4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform 1 [Homo sapiens];gi|197927274|ref|NP_001128142.1|//4-hydroxy-2-oxoglutarate aldolase, mitochondrial isoform 2 [Homo sapiens]"]
[100133941,2424,5.31,2.24,-1.24521312874655,5.86331326651481e-5,"Down",9.54038e-6,"CD24","NA","NA","NA","K12581//CCR4-NOT transcription complex subunit 7/8;K11447//histone demethylase [EC:1.14.11.-];K17985//activating molecule in BECN1-regulated autophagy protein 1;K06469//CD24 antigen","gi|34531772|dbj|BAC86222.1|//unnamed protein product [Homo sapiens];gi|297678812|ref|XP_002817254.1|//PREDICTED: signal transducer CD24 isoform X1 [Pongo abelii];gi|619329010|ref|NP_001278668.1|//signal transducer CD24 isoform b [Homo sapiens]"]
[11007,1277,73.77,31.13,-1.24472865884806,4.55069861333333e-35,"Down",8.85514e-37,"CCDC85B","GO:0043231//intracellular membrane-bounded organelle;GO:0005815//microtubule organizing center","GO:0005488//binding","GO:0016049//cell growth","K16758//coiled-coil domain-containing protein 85B","gi|942050138|ref|XP_005911948.2|//PREDICTED: LOW QUALITY PROTEIN: coiled-coil domain-containing protein 85B [Bos mutus]"]
[84695,2864,4.95,2.09,-1.24392558288609,1.76514277386935e-5,"Down",2.60388e-6,"LOXL3","GO:0044421//extracellular region part;GO:0005576//extracellular region;GO:0044464//cell part","GO:0016641//oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor;GO:0004888//transmembrane signaling receptor activity;GO:0046914//transition metal ion binding;GO:0003824//catalytic activity","GO:0008152//metabolic process","K00280//lysyl oxidase-like protein 2/3/4 [EC:1.4.3.-]","gi|14211943|ref|NP_115992.1|//lysyl oxidase homolog 3 isoform 1 precursor [Homo sapiens];gi|332239116|ref|XP_003268751.1|//PREDICTED: lysyl oxidase homolog 3 isoform X3 [Nomascus leucogenys];gi|574957232|ref|NP_001276093.1|//lysyl oxidase homolog 3 isoform 2 precursor [Homo sapiens]"]
[4016,2243,12.72,5.38,-1.24142059272773,4.63671048247423e-9,"Down",4.16754e-10,"LOXL1","GO:0044421//extracellular region part","GO:0046872//metal ion binding;GO:0016638//oxidoreductase activity, acting on the CH-NH2 group of donors;GO:0046914//transition metal ion binding;GO:0016491//oxidoreductase activity","GO:0006464//cellular protein modification process","K14678//lysyl oxidase-like protein 1 [EC:1.4.3.-]","gi|671032145|ref|XP_008706873.1|//PREDICTED: lysyl oxidase homolog 1 [Ursus maritimus];gi|767984124|ref|XP_011519857.1|//PREDICTED: lysyl oxidase homolog 1 isoform X1 [Homo sapiens];gi|67782346|ref|NP_005567.2|//lysyl oxidase homolog 1 preproprotein [Homo sapiens]"]
[6509,4611,3.47,1.47,-1.2391195077419,1.50543108231798e-6,"Down",1.877604e-7,"SLC1A4","GO:0043229//intracellular organelle;GO:0043234//protein complex;GO:0016021//integral component of membrane;GO:0048770//pigment granule","GO:0005310//dicarboxylic acid transmembrane transporter activity;GO:0015291//secondary active transmembrane transporter activity;GO:0005253//anion channel activity;GO:0015175//neutral amino acid transmembrane transporter activity;GO:0015179//L-amino acid transmembrane transporter activity;GO:0000099//sulfur amino acid transmembrane transporter activity","GO:0015807//L-amino acid transport;GO:0006807//nitrogen compound metabolic process;GO:0000101//sulfur amino acid transport;GO:0003333//amino acid transmembrane transport;GO:0015804//neutral amino acid transport;GO:0015718//monocarboxylic acid transport;GO:0015698//inorganic anion transport;GO:0007270//neuron-neuron synaptic transmission","K05615//solute carrier family 1 (glutamate/neutral amino acid transporter), member 4","gi|507137|gb|AAA19438.1|//neutral amino acid transporter [Homo sapiens];gi|471357468|ref|XP_004369325.1|//PREDICTED: neutral amino acid transporter A isoform X2 [Trichechus manatus latirostris]"]
[30833,954,59.53,25.3,-1.23447950944644,1.33649707317073e-21,"Down",4.4005e-23,"NT5C","GO:0043231//intracellular membrane-bounded organelle;GO:0044444//cytoplasmic part","GO:0043169//cation binding;GO:0000166//nucleotide binding;GO:0008252//nucleotidase activity","GO:0009112//nucleobase metabolic process;GO:0006213//pyrimidine nucleoside metabolic process;GO:0006163//purine nucleotide metabolic process;GO:0006796//phosphate-containing compound metabolic process;GO:0006244//pyrimidine nucleotide catabolic process","K01081//5'-nucleotidase [EC:3.1.3.5]","gi|119609649|gb|EAW89243.1|//5', 3'-nucleotidase, cytosolic, isoform CRA_c [Homo sapiens];gi|918656584|ref|XP_013364104.1|//PREDICTED: 5'(3')-deoxyribonucleotidase, cytosolic type isoform X1 [Chinchilla lanigera];gi|967210597|ref|XP_001093693.3|//PREDICTED: 5'(3')-deoxyribonucleotidase, cytosolic type isoform X1 [Macaca mulatta]"]
[57593,2813,4.11,1.75,-1.23178347184935,4.52894060474155e-5,"Down",7.19852e-6,"EBF4","GO:0043231//intracellular membrane-bounded organelle","GO:0043169//cation binding;GO:0003676//nucleic acid binding","GO:0032501//multicellular organismal process;GO:0006351//transcription, DNA-templated","K09103//early B-cell factor","gi|160333411|ref|NP_001103984.1|//transcription factor COE4 [Homo sapiens];gi|152031576|sp|Q9BQW3.2|COE4_HUMAN//RecName: Full=Transcription factor COE4; AltName: Full=Early B-cell factor 4; Short=EBF-4; AltName: Full=Olf-1/EBF-like 4; Short=O/E-4; Short=OE-4;gi|426390740|ref|XP_004061757.1|//PREDICTED: transcription factor COE4 [Gorilla gorilla gorilla]"]
[5567,3977,5.48,2.34,-1.22766736337712,9.26232082855471e-8,"Down",9.77842e-9,"PRKACB","GO:0016020//membrane;GO:0031981//nuclear lumen;GO:0043234//protein complex;GO:0045202//synapse;GO:0044444//cytoplasmic part","GO:0046872//metal ion binding;GO:0032559//adenyl ribonucleotide binding;GO:0019900//kinase binding;GO:0004690//cyclic nucleotide-dependent protein kinase activity","GO:0051969//regulation of transmission of nerve impulse;GO:0006006//glucose metabolic process;GO:0006641//triglyceride metabolic process;GO:0032147//activation of protein kinase activity;GO:0001704//formation of primary germ layer;GO:0032870//cellular response to hormone stimulus;GO:0030073//insulin secretion;GO:0010863//positive regulation of phospholipase C activity;GO:0015980//energy derivation by oxidation of organic compounds;GO:0046824//positive regulation of nucleocytoplasmic transport;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0033762//response to glucagon;GO:0007599//hemostasis;GO:0042044//fluid transport;GO:0007187//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger","K04345//protein kinase A [EC:2.7.11.11]","gi|530362942|ref|XP_005271072.1|//PREDICTED: cAMP-dependent protein kinase catalytic subunit beta isoform X3 [Homo sapiens];gi|530362944|ref|XP_005271073.1|//PREDICTED: cAMP-dependent protein kinase catalytic subunit beta isoform X4 [Homo sapiens];gi|530362946|ref|XP_005271074.1|//PREDICTED: cAMP-dependent protein kinase catalytic subunit beta isoform X5 [Homo sapiens];gi|665506018|ref|NP_001287846.1|//cAMP-dependent protein kinase catalytic subunit beta isoform 12 [Homo sapiens] ;gi|338827755|ref|NP_001229787.1|//cAMP-dependent protein kinase catalytic subunit beta isoform 5 [Homo sapiens] ;gi|338827761|ref|NP_001229790.1|//cAMP-dependent protein kinase catalytic subunit beta isoform 8 [Homo sapiens] ;gi|46909587|ref|NP_997461.1|//cAMP-dependent protein kinase catalytic subunit beta isoform 3 [Homo sapiens];gi|33636738|ref|NP_891993.1|//cAMP-dependent protein kinase catalytic subunit beta isoform 1 [Homo sapiens];gi|4506057|ref|NP_002722.1|//cAMP-dependent protein kinase catalytic subunit beta isoform 2 [Homo sapiens];gi|767905097|ref|XP_011540066.1|//PREDICTED: cAMP-dependent protein kinase catalytic subunit beta isoform X2 [Homo sapiens];gi|197100271|ref|NP_001127665.1|//cAMP-dependent protein kinase catalytic subunit beta isoform 2 [Pongo abelii] ;gi|62087958|dbj|BAD92426.1|//cAMP-dependent protein kinase catalytic subunit beta isoform 2 variant [Homo sapiens];gi|465968251|ref|XP_004263001.1|//PREDICTED: cAMP-dependent protein kinase catalytic subunit beta isoform X7 [Orcinus orca];gi|544404855|ref|XP_005542961.1|//PREDICTED: cAMP-dependent protein kinase catalytic subunit beta isoform X9 [Macaca fascicularis];gi|635106984|ref|XP_007976355.1|//PREDICTED: cAMP-dependent protein kinase catalytic subunit beta isoform X16 [Chlorocebus sabaeus];gi|665506014|ref|NP_001287844.1|//cAMP-dependent protein kinase catalytic subunit beta isoform 10 [Homo sapiens] ;gi|530362950|ref|XP_005271076.1|//PREDICTED: cAMP-dependent protein kinase catalytic subunit beta isoform X7 [Homo sapiens];gi|530362952|ref|XP_005271077.1|//PREDICTED: cAMP-dependent protein kinase catalytic subunit beta isoform X8 [Homo sapiens];gi|665506016|ref|NP_001287845.1|//cAMP-dependent protein kinase catalytic subunit beta isoform 11 [Homo sapiens] ;gi|530362948|ref|XP_005271075.1|//PREDICTED: cAMP-dependent protein kinase catalytic subunit beta isoform X6 [Homo sapiens]"]
[54938,2077,11.03,4.73,-1.22152070225199,8.77286272340426e-9,"Down",8.15072e-10,"SARS2","GO:0044429//mitochondrial part","GO:0032559//adenyl ribonucleotide binding;GO:0004812//aminoacyl-tRNA ligase activity","GO:0006418//tRNA aminoacylation for protein translation","K01875//seryl-tRNA synthetase [EC:6.1.1.11]","gi|8923421|ref|NP_060297.1|//serine--tRNA ligase, mitochondrial isoform b precursor [Homo sapiens];gi|225579074|ref|NP_001139373.1|//serine--tRNA ligase, mitochondrial isoform a precursor [Homo sapiens] "]
[90557,1445,14.32,6.16,-1.21702923656936,6.70153113887455e-7,"Down",8.01882e-8,"CCDC74A","NA","NA","NA","K09228//KRAB domain-containing zinc finger protein;K13024//inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase [EC:2.7.4.24];K17776//metaxin","gi|767920510|ref|XP_011510445.1|//PREDICTED: coiled-coil domain-containing protein 74B isoform X8 [Homo sapiens];gi|327131637|dbj|BAK08536.1|//CCDC74A isoform 2 [Homo sapiens];gi|20270307|ref|NP_620125.1|//coiled-coil domain-containing protein 74A isoform 1 [Homo sapiens];gi|767920512|ref|XP_011510446.1|//PREDICTED: coiled-coil domain-containing protein 74B isoform X9 [Homo sapiens];gi|767920516|ref|XP_011510448.1|//PREDICTED: coiled-coil domain-containing protein 74B isoform X11 [Homo sapiens];gi|530369537|ref|XP_005263892.1|//PREDICTED: coiled-coil domain-containing protein 74A isoform X3 [Homo sapiens];gi|767920514|ref|XP_011510447.1|//PREDICTED: coiled-coil domain-containing protein 74B isoform X10 [Homo sapiens];gi|578805108|ref|XP_006712891.1|//PREDICTED: coiled-coil domain-containing protein 74A isoform X2 [Homo sapiens];gi|119632097|gb|EAX11692.1|//hCG2014503, isoform CRA_a [Homo sapiens];gi|530369539|ref|XP_005263893.1|//PREDICTED: coiled-coil domain-containing protein 74A isoform X1 [Homo sapiens];gi|385198100|ref|NP_001245233.1|//coiled-coil domain-containing protein 74A isoform 2 [Homo sapiens];gi|385198104|ref|NP_001245235.1|//coiled-coil domain-containing protein 74A isoform 4 [Homo sapiens]"]
[10124,3031,9.22,3.97,-1.21562774328638,1.23110078661088e-10,"Down",9.088e-12,"ARL4A","GO:0031981//nuclear lumen;GO:0016020//membrane","GO:0032561//guanyl ribonucleotide binding;GO:0017111//nucleoside-triphosphatase activity","GO:0045444//fat cell differentiation;GO:0035556//intracellular signal transduction","K07945//ADP-ribosylation factor-like protein 4","gi|820979707|ref|XP_003255929.2|//PREDICTED: ADP-ribosylation factor-like protein 4A [Nomascus leucogenys];gi|440894615|gb|ELR47022.1|//ADP-ribosylation factor-like protein 4A, partial [Bos mutus]"]
[8763,3122,80.64,34.81,-1.21199382477623,1.71953205362637e-91,"Down",9.66626e-94,"CD164","GO:0031090//organelle membrane;GO:0016021//integral component of membrane;GO:0005764//lysosome","GO:0005488//binding","GO:0008283//cell proliferation;GO:0016337//single organismal cell-cell adhesion;GO:0023052//signaling;GO:0048534//hematopoietic or lymphoid organ development","K06546//CD164 antigen","gi|215422427|ref|NP_001135876.1|//sialomucin core protein 24 isoform 5 precursor [Homo sapiens] ;gi|215422425|ref|NP_001135875.1|//sialomucin core protein 24 isoform 4 precursor [Homo sapiens];gi|215422421|ref|NP_001135873.1|//sialomucin core protein 24 isoform 2 precursor [Homo sapiens];gi|215422423|ref|NP_001135874.1|//sialomucin core protein 24 isoform 3 precursor [Homo sapiens];gi|21361274|ref|NP_006007.2|//sialomucin core protein 24 isoform 1 precursor [Homo sapiens]"]
[79038,1486,21,9.07,-1.21121487202496,8.08920559659574e-11,"Down",5.87152e-12,"ZFYVE21","GO:0031410//cytoplasmic vesicle;GO:0005924//cell-substrate adherens junction","GO:0046914//transition metal ion binding","NA","K00921//1-phosphatidylinositol-3-phosphate 5-kinase [EC:2.7.1.150]","gi|312147341|ref|NP_001185882.1|//zinc finger FYVE domain-containing protein 21 isoform 1 [Homo sapiens];gi|13129054|ref|NP_076976.1|//zinc finger FYVE domain-containing protein 21 isoform 2 [Homo sapiens]"]
[9555,2125,108.05,46.67,-1.21113169978273,5.92244725e-68,"Down",5.2683e-70,"H2AFY","GO:0043231//intracellular membrane-bounded organelle;GO:0000228//nuclear chromosome;GO:0005815//microtubule organizing center;GO:0000785//chromatin","GO:0003676//nucleic acid binding","GO:0034728//nucleosome organization;GO:0040029//regulation of gene expression, epigenetic","K11251//histone H2A","gi|640816353|ref|XP_008064981.1|//PREDICTED: core histone macro-H2A.1 isoform X1 [Tarsius syrichta];gi|537195241|gb|ERE78041.1|//core histone macro-H2A.1 isoform 2 [Cricetulus griseus];gi|658920935|ref|XP_008400201.1|//PREDICTED: core histone macro-H2A.1 [Poecilia reticulata];gi|640816359|ref|XP_008064984.1|//PREDICTED: core histone macro-H2A.1 isoform X4 [Tarsius syrichta];gi|20336746|ref|NP_613075.1|//core histone macro-H2A.1 isoform 1 [Homo sapiens];gi|946761485|ref|XP_014394637.1|//PREDICTED: core histone macro-H2A.1 isoform X1 [Myotis brandtii];gi|767936786|ref|XP_011542035.1|//PREDICTED: core histone macro-H2A.1 isoform X6 [Homo sapiens];gi|984105473|ref|XP_015344068.1|//PREDICTED: core histone macro-H2A.1 isoform X4 [Marmota marmota marmota];gi|3493529|gb|AAC33433.1|//histone macroH2A1.2 [Homo sapiens];gi|530380261|ref|XP_005272191.1|//PREDICTED: core histone macro-H2A.1 isoform X7 [Homo sapiens];gi|946761489|ref|XP_014394639.1|//PREDICTED: core histone macro-H2A.1 isoform X3 [Myotis brandtii];gi|946761487|ref|XP_014394638.1|//PREDICTED: core histone macro-H2A.1 isoform X2 [Myotis brandtii];gi|821416310|ref|XP_012393015.1|//PREDICTED: core histone macro-H2A.1 isoform X5 [Orcinus orca];gi|640816355|ref|XP_008064982.1|//PREDICTED: core histone macro-H2A.1 isoform X2 [Tarsius syrichta];gi|530380263|ref|XP_005272192.1|//PREDICTED: core histone macro-H2A.1 isoform X8 [Homo sapiens];gi|984105471|ref|XP_015344067.1|//PREDICTED: core histone macro-H2A.1 isoform X3 [Marmota marmota marmota]"]
[643155,2895,12.66,5.47,-1.21066466663578,7.24950789261745e-14,"Down",4.00362e-15,"SMIM15","GO:0031224//intrinsic component of membrane","NA","NA","NA","gi|625183292|ref|XP_007646152.1|//PREDICTED: small integral membrane protein 15 isoform X1 [Cricetulus griseus]"]
[64710,6173,120.57,52.2,-1.20774927132265,3.189532432e-268,"Down",2.95546e-271,"NUCKS1","NA","NA","NA","NA","gi|11493465|gb|AAG35506.1|AF130117_39//PRO2870 [Homo sapiens];gi|148707748|gb|EDL39695.1|//nuclear casein kinase and cyclin-dependent kinase substrate 1, isoform CRA_b, partial [Mus musculus]"]
[51088,5268,15.68,6.8,-1.20531890797751,7.22804845170068e-27,"Down",1.969094e-28,"KLHL5","GO:0043232//intracellular non-membrane-bounded organelle","GO:0008092//cytoskeletal protein binding","NA","K10442//kelch-like protein 1/4/5","gi|530376491|ref|XP_005262712.1|//PREDICTED: kelch-like protein 5 isoform X2 [Homo sapiens];gi|767930340|ref|XP_011512001.1|//PREDICTED: kelch-like protein 5 isoform X1 [Homo sapiens];gi|767930343|ref|XP_011512002.1|//PREDICTED: kelch-like protein 5 isoform X3 [Homo sapiens];gi|65289292|ref|NP_057074.3|//kelch-like protein 5 isoform 1 [Homo sapiens];gi|62087220|dbj|BAD92057.1|//kelch-like 5 isoform 2 variant [Homo sapiens];gi|65289632|ref|NP_950240.2|//kelch-like protein 5 isoform 2 [Homo sapiens] "]
[2188,3309,4.72,2.05,-1.2031629498564,2.62923631413613e-6,"Down",3.41242e-7,"FANCF","GO:0031981//nuclear lumen","GO:0005488//binding","GO:0006259//DNA metabolic process","K10893//fanconi anemia group F protein","gi|34365355|emb|CAE45999.1|//hypothetical protein [Homo sapiens]"]
[5740,5603,1.68,0.73,-1.20249286389874,0.000433945145454545,"Down",8.37438e-5,"PTGIS","GO:0031224//intrinsic component of membrane;GO:0031090//organelle membrane;GO:0044432//endoplasmic reticulum part","GO:0005506//iron ion binding;GO:0016860//intramolecular oxidoreductase activity;GO:0016491//oxidoreductase activity","GO:0009058//biosynthetic process;GO:0006693//prostaglandin metabolic process","K01831//prostacyclin synthase [EC:5.3.99.4]","gi|160877910|pdb|3B6H|A//Chain A, Crystal Structure Of Human Prostacyclin Synthase In Complex With Inhibitor Minoxidil"]
[6604,1710,12.22,5.31,-1.20246051901458,1.08294076999423e-7,"Down",1.159338e-8,"SMARCD3","GO:0031981//nuclear lumen;GO:0070603//SWI/SNF superfamily-type complex","GO:0051427//hormone receptor binding;GO:0003712//transcription cofactor activity","GO:0051098//regulation of binding;GO:0009887//animal organ morphogenesis;GO:0030154//cell differentiation;GO:0006325//chromatin organization;GO:0006355//regulation of transcription, DNA-templated;GO:0006629//lipid metabolic process","K11650//SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D","gi|77404373|ref|NP_080167.3|//SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 [Mus musculus];gi|221042014|dbj|BAH12684.1|//unnamed protein product [Homo sapiens];gi|149046518|gb|EDL99343.1|//rCG24403, isoform CRA_b [Rattus norvegicus];gi|966936274|ref|XP_014990694.1|//PREDICTED: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X1 [Macaca mulatta];gi|332243626|ref|XP_003270979.1|//PREDICTED: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X1 [Nomascus leucogenys];gi|953851600|ref|XP_001914781.2|//PREDICTED: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3, partial [Equus caballus]"]
[9415,3117,30.32,13.18,-1.20191938316304,2.445920464e-36,"Down",4.53284e-38,"FADS2","GO:0043231//intracellular membrane-bounded organelle;GO:0031090//organelle membrane;GO:0016021//integral component of membrane","GO:0005506//iron ion binding;GO:0016215//acyl-CoA desaturase activity","GO:0006091//generation of precursor metabolites and energy;GO:0006633//fatty acid biosynthetic process;GO:0051234//establishment of localization","K10226//acyl-CoA 6-desaturase (Delta-6 desaturase) [EC:1.14.19.3]","gi|4758334|ref|NP_004256.1|//fatty acid desaturase 2 isoform 1 [Homo sapiens];gi|527498295|ref|NP_001268430.1|//fatty acid desaturase 2 isoform 2 precursor [Homo sapiens];gi|527498297|ref|NP_001268431.1|//fatty acid desaturase 2 isoform 3 [Homo sapiens] "]
[91860,4573,2.3,1,-1.20163386116965,0.000185786617954939,"Down",3.31106e-5,"CALML4","NA","GO:0046872//metal ion binding","NA","K02183//calmodulin","gi|12060826|gb|AAG48255.1|AF308287_1//serologically defined breast cancer antigen NY-BR-20 [Homo sapiens];gi|110227596|ref|NP_001026903.2|//calmodulin-like protein 4 isoform 2 [Homo sapiens];gi|110227594|ref|NP_219501.2|//calmodulin-like protein 4 isoform 1 [Homo sapiens]"]
[2296,3452,4.04,1.76,-1.1987798641145,1.42208105737357e-5,"Down",2.06706e-6,"FOXC1","GO:0000790//nuclear chromatin","GO:0000981//RNA polymerase II transcription factor activity, sequence-specific DNA binding;GO:0043566//structure-specific DNA binding;GO:0005515//protein binding;GO:0043565//sequence-specific DNA binding","GO:0009952//anterior/posterior pattern specification;GO:0048771//tissue remodeling;GO:0035272//exocrine system development;GO:0035295//tube development;GO:0001822//kidney development;GO:0007346//regulation of mitotic cell cycle;GO:0014031//mesenchymal cell development;GO:0040008//regulation of growth;GO:0043009//chordate embryonic development;GO:0055008//cardiac muscle tissue morphogenesis;GO:0001707//mesoderm formation;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0003018//vascular process in circulatory system;GO:0014855//striated muscle cell proliferation;GO:0007276//gamete generation;GO:0042476//odontogenesis;GO:0022602//ovulation cycle process;GO:0045165//cell fate commitment;GO:0001654//eye development;GO:0001945//lymph vessel development;GO:0043066//negative regulation of apoptotic process;GO:0007417//central nervous system development;GO:0048514//blood vessel morphogenesis;GO:0030198//extracellular matrix organization;GO:0006022//aminoglycan metabolic process","K09396//forkhead box protein C","gi|3859930|gb|AAC72915.1|//forkhead/winged helix-like transcription factor 7 [Homo sapiens]"]
[130576,1419,10.34,4.52,-1.19384150789975,4.63672816643551e-6,"Down",6.19548e-7,"LYPD6B","GO:0031224//intrinsic component of membrane","NA","NA","K08576//calpain-7 [EC:3.4.22.-]","gi|530369831|ref|XP_005246363.1|//PREDICTED: ly6/PLAUR domain-containing protein 6B isoform X8 [Homo sapiens];gi|767916722|ref|XP_011508924.1|//PREDICTED: ly6/PLAUR domain-containing protein 6B isoform X7 [Homo sapiens];gi|767916718|ref|XP_011508922.1|//PREDICTED: ly6/PLAUR domain-containing protein 6B isoform X5 [Homo sapiens];gi|62822426|gb|AAY14974.1|//unknown [Homo sapiens];gi|767916716|ref|XP_011508921.1|//PREDICTED: ly6/PLAUR domain-containing protein 6B isoform X4 [Homo sapiens];gi|578803704|ref|XP_006712343.1|//PREDICTED: ly6/PLAUR domain-containing protein 6B isoform X9 [Homo sapiens]"]
[1796,2162,12.4,5.43,-1.19131601746988,1.71280539672131e-11,"Down",1.161762e-12,"DOK1","GO:0044444//cytoplasmic part","GO:0005102//receptor binding","GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0007264//small GTPase mediated signal transduction","K14752//docking protein 1","gi|2661056|gb|AAB88182.1|//similar to GAP binding protein p62do [Homo sapiens];gi|426336074|ref|XP_004029529.1|//PREDICTED: docking protein 1 isoform 1 [Gorilla gorilla gorilla];gi|731232369|ref|XP_010629898.1|//PREDICTED: docking protein 1 isoform X2 [Fukomys damarensis];gi|767914103|ref|XP_011530972.1|//PREDICTED: docking protein 1 isoform X2 [Homo sapiens];gi|686706860|ref|XP_009235425.1|//PREDICTED: docking protein 1 isoform X2 [Pongo abelii];gi|4503357|ref|NP_001372.1|//docking protein 1 isoform a [Homo sapiens]"]
[25816,2098,7.45,3.27,-1.18794978985144,6.00530650909091e-6,"Down",8.1614e-7,"TNFAIP8","GO:0044424//intracellular part","GO:0005488//binding;GO:0004869//cysteine-type endopeptidase inhibitor activity","NA","K15289//solute carrier family 35, member F5","gi|117676370|ref|NP_001071122.1|//tumor necrosis factor alpha-induced protein 8 isoform b [Homo sapiens];gi|558472822|ref|NP_001273743.1|//tumor necrosis factor alpha-induced protein 8 isoform c [Homo sapiens] ;gi|426349727|ref|XP_004042440.1|//PREDICTED: tumor necrosis factor alpha-induced protein 8 isoform 5 [Gorilla gorilla gorilla];gi|795314011|ref|XP_011925788.1|//PREDICTED: tumor necrosis factor alpha-induced protein 8 isoform X1 [Cercocebus atys];gi|694912081|ref|XP_009447818.1|//PREDICTED: tumor necrosis factor alpha-induced protein 8 isoform X1 [Pan troglodytes];gi|725550770|ref|XP_010337813.1|//PREDICTED: tumor necrosis factor alpha-induced protein 8 isoform X1 [Saimiri boliviensis boliviensis]"]
[4638,6698,11.98,5.26,-1.18749320349648,1.22237161128527e-18,"Down",4.8176e-20,"MYLK","GO:0044444//cytoplasmic part","GO:0043169//cation binding;GO:0005515//protein binding;GO:0004674//protein serine/threonine kinase activity;GO:0000166//nucleotide binding;GO:0032559//adenyl ribonucleotide binding;GO:0008092//cytoskeletal protein binding;GO:0016740//transferase activity","GO:0006464//cellular protein modification process;GO:0003012//muscle system process;GO:0060415//muscle tissue morphogenesis","K00907//myosin-light-chain kinase [EC:2.7.11.18]","gi|116008188|ref|NP_444254.3|//myosin light chain kinase, smooth muscle isoform 2 [Homo sapiens];gi|942048350|ref|XP_014332957.1|//PREDICTED: myosin light chain kinase, smooth muscle isoform X9 [Bos mutus];gi|116008190|ref|NP_444256.3|//myosin light chain kinase, smooth muscle isoform 3B [Homo sapiens];gi|116008194|ref|NP_444255.3|//myosin light chain kinase, smooth muscle isoform 3A [Homo sapiens];gi|987429960|ref|XP_015400277.1|//PREDICTED: myosin light chain kinase, smooth muscle isoform X3 [Panthera tigris altaica];gi|767926843|ref|XP_011511163.1|//PREDICTED: myosin light chain kinase, smooth muscle isoform X2 [Homo sapiens];gi|585197586|ref|XP_006749840.1|//PREDICTED: myosin light chain kinase, smooth muscle-like isoform X2 [Leptonychotes weddellii];gi|7239698|gb|AAD15921.2|//myosin light chain kinase isoform 2 [Homo sapiens];gi|767926841|ref|XP_011511162.1|//PREDICTED: myosin light chain kinase, smooth muscle isoform X1 [Homo sapiens];gi|585197584|ref|XP_006749839.1|//PREDICTED: myosin light chain kinase, smooth muscle-like isoform X1 [Leptonychotes weddellii];gi|116008192|ref|NP_444253.3|//myosin light chain kinase, smooth muscle isoform 1 [Homo sapiens]"]
[7402,10844,24.34,10.69,-1.18706731499324,1.80454642746269e-115,"Down",7.46878e-118,"UTRN","GO:0016020//membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0044459//plasma membrane part;GO:0043232//intracellular non-membrane-bounded organelle;GO:0031981//nuclear lumen;GO:0030427//site of polarized growth;GO:0015629//actin cytoskeleton;GO:0045202//synapse","GO:0003779//actin binding;GO:0008092//cytoskeletal protein binding;GO:0046914//transition metal ion binding","GO:0007525//somatic muscle development;GO:0001952//regulation of cell-matrix adhesion;GO:0048513//animal organ development;GO:0003012//muscle system process;GO:0048741//skeletal muscle fiber development","K10366//dystrophin","gi|530384027|ref|XP_005267184.1|//PREDICTED: utrophin isoform X5 [Homo sapiens];gi|110611228|ref|NP_009055.2|//utrophin [Homo sapiens];gi|767943517|ref|XP_011534403.1|//PREDICTED: utrophin isoform X2 [Homo sapiens];gi|530384039|ref|XP_005267190.1|//PREDICTED: utrophin isoform X6 [Homo sapiens];gi|578812961|ref|XP_006715623.1|//PREDICTED: utrophin isoform X10 [Homo sapiens];gi|767943523|ref|XP_011534406.1|//PREDICTED: utrophin isoform X3 [Homo sapiens];gi|767943530|ref|XP_011534409.1|//PREDICTED: utrophin isoform X7 [Homo sapiens];gi|767943525|ref|XP_011534407.1|//PREDICTED: utrophin isoform X4 [Homo sapiens];gi|767943534|ref|XP_011534411.1|//PREDICTED: utrophin isoform X9 [Homo sapiens]"]
[928,1321,26.89,11.81,-1.18706079047572,1.16179232224449e-12,"Down",7.16252e-14,"CD9","GO:0030667//secretory granule membrane;GO:0044459//plasma membrane part;GO:0016021//integral component of membrane","GO:0005102//receptor binding","GO:0007043//cell-cell junction assembly;GO:0006950//response to stress;GO:0007417//central nervous system development;GO:0021782//glial cell development;GO:0001775//cell activation;GO:0008283//cell proliferation;GO:0007338//single fertilization;GO:0007599//hemostasis;GO:0006887//exocytosis","K06460//CD9 antigen","gi|795107043|ref|XP_011807041.1|//PREDICTED: CD9 antigen isoform X1 [Colobus angolensis palliatus];gi|530398937|ref|XP_005253871.1|//PREDICTED: CD9 antigen isoform X1 [Homo sapiens]"]
[64115,4774,5.95,2.62,-1.18332285665786,2.04731570081833e-10,"Down",1.545478e-11,"VSIR","GO:0031224//intrinsic component of membrane","GO:0004871//signal transducer activity","NA","NA","gi|724872530|ref|XP_010371348.1|//PREDICTED: platelet receptor Gi24 [Rhinopithecus roxellana]"]
[195828,3689,18.91,8.34,-1.1810300745051,6.79584612993631e-25,"Down",1.977294e-26,"ZNF367","GO:0031981//nuclear lumen","GO:0046872//metal ion binding;GO:0001071//nucleic acid binding transcription factor activity;GO:0003676//nucleic acid binding","GO:0006355//regulation of transcription, DNA-templated","K09229//KRAB and SCAN domains-containing zinc finger protein","gi|24233572|ref|NP_710162.1|//zinc finger protein 367 [Homo sapiens];gi|767956564|ref|XP_011516647.1|//PREDICTED: zinc finger protein 367 isoform X1 [Homo sapiens]"]
[7108,1614,20.7,9.13,-1.18094400240247,6.42558522671684e-12,"Down",4.21942e-13,"TM7SF2","GO:0043231//intracellular membrane-bounded organelle;GO:0031090//organelle membrane;GO:0016021//integral component of membrane","GO:0016628//oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor","GO:0008203//cholesterol metabolic process","K00222//Delta14-sterol reductase [EC:1.3.1.70]","gi|469663653|ref|NP_001264162.1|//delta(14)-sterol reductase isoform 2 [Homo sapiens];gi|117414150|ref|NP_003264.2|//delta(14)-sterol reductase isoform 1 [Homo sapiens]"]
[9926,6571,20.88,9.21,-1.18084865047855,1.33895617615385e-48,"Down",1.720428e-50,"LPGAT1","GO:0031224//intrinsic component of membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0031090//organelle membrane","GO:0016747//transferase activity, transferring acyl groups other than amino-acyl groups","GO:0006644//phospholipid metabolic process","K13514//lysophosphatidylglycerol acyltransferase 1 [EC:2.3.1.-]","gi|966922070|ref|XP_014972816.1|//PREDICTED: acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X5 [Macaca mulatta];gi|530366682|ref|XP_005273419.1|//PREDICTED: acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X2 [Homo sapiens];gi|675747657|ref|XP_003735271.2|//PREDICTED: acyl-CoA:lysophosphatidylglycerol acyltransferase 1 isoform X2 [Callithrix jacchus];gi|7661996|ref|NP_055688.1|//acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [Homo sapiens]"]
[4835,1309,51.77,22.87,-1.17865995244925,1.465924575e-20,"Down",5.21604e-22,"NQO2","GO:0031981//nuclear lumen","GO:0043169//cation binding;GO:0048037//cofactor binding;GO:0003959//NADPH dehydrogenase activity","GO:0008152//metabolic process","K08071//ribosyldihydronicotinamide dehydrogenase (quinone) [EC:1.10.5.1]","gi|224983640|pdb|3FW1|A//Chain A, Quinone Reductase 2;gi|589811532|ref|NP_001277151.1|//ribosyldihydronicotinamide dehydrogenase [quinone] isoform 2 [Homo sapiens]"]
[55728,8123,4.84,2.14,-1.17739625087345,8.82589927474972e-14,"Down",4.90146e-15,"N4BP2","GO:0044424//intracellular part","GO:0032559//adenyl ribonucleotide binding;GO:0051733//polydeoxyribonucleotide kinase activity;GO:0004518//nuclease activity","NA","K15720//NEDD4-binding protein 2 [EC:3.-.-.-]","gi|31742492|ref|NP_060647.2|//NEDD4-binding protein 2 isoform 1 [Homo sapiens];gi|767930380|ref|XP_011512017.1|//PREDICTED: NEDD4-binding protein 2 isoform X2 [Homo sapiens]"]
[1595,3178,38.75,17.15,-1.17598773398879,1.41755687179487e-42,"Down",2.0491e-44,"CYP51A1","GO:0031224//intrinsic component of membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0031090//organelle membrane","GO:0016709//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0005506//iron ion binding","GO:0006694//steroid biosynthetic process;GO:0008203//cholesterol metabolic process;GO:0044237//cellular metabolic process","K05917//sterol 14-demethylase [EC:1.14.13.70]","gi|3915660|sp|Q16850.3|CP51A_HUMAN//RecName: Full=Lanosterol 14-alpha demethylase; Short=LDM; AltName: Full=CYPLI; AltName: Full=Cytochrome P450 51A1; AltName: Full=Cytochrome P450-14DM; Short=Cytochrome P45014DM; AltName: Full=Cytochrome P450LI; AltName: Full=Sterol 14-alpha demethylase"]
[64787,3223,21.46,9.54,-1.16958890475101,2.7885135483871e-23,"Down",8.544e-25,"EPS8L2","GO:0044424//intracellular part","NA","NA","K17277//epidermal growth factor receptor kinase substrate 8","gi|821029994|ref|XP_012359241.1|//PREDICTED: LOW QUALITY PROTEIN: epidermal growth factor receptor kinase substrate 8-like protein 2 [Nomascus leucogenys];gi|119622781|gb|EAX02376.1|//EPS8-like 2, isoform CRA_b [Homo sapiens]"]
[117583,8114,1.37,0.61,-1.16729474539764,4.52718110955711e-5,"Down",7.19852e-6,"PARD3B","GO:0043296//apical junction complex","NA","GO:0009987//cellular process","K04237//partitioning defective protein 3","gi|119120897|ref|NP_689739.4|//partitioning defective 3 homolog B isoform Par3Lb [Homo sapiens];gi|718550767|ref|NP_001289698.1|//partitioning defective 3 homolog B isoform Par3La [Homo sapiens];gi|767916522|ref|XP_011508854.1|//PREDICTED: partitioning defective 3 homolog B isoform X3 [Homo sapiens];gi|119120907|ref|NP_995585.2|//partitioning defective 3 homolog B isoform 4 [Homo sapiens] ;gi|767916524|ref|XP_011508855.1|//PREDICTED: partitioning defective 3 homolog B isoform X4 [Homo sapiens];gi|119120903|ref|NP_476518.4|//partitioning defective 3 homolog B isoform Par3Lc [Homo sapiens]"]
[28981,2821,17.86,7.96,-1.16589174457757,3.86973614415584e-19,"Down",1.472546e-20,"IFT81","GO:0005815//microtubule organizing center;GO:0030990//intraciliary transport particle","NA","GO:0048232//male gamete generation;GO:0048869//cellular developmental process","K19677//intraflagellar transport protein 81","gi|32526901|ref|NP_054774.2|//intraflagellar transport protein 81 homolog isoform 1 [Homo sapiens];gi|767973959|ref|XP_011536535.1|//PREDICTED: intraflagellar transport protein 81 homolog isoform X2 [Homo sapiens];gi|507676543|ref|XP_004709764.1|//PREDICTED: intraflagellar transport protein 81 homolog [Echinops telfairi];gi|34147403|ref|NP_113661.2|//intraflagellar transport protein 81 homolog isoform 2 [Homo sapiens]"]
[80311,6488,4.9,2.19,-1.1618508794014,2.58734272991914e-11,"Down",1.778918e-12,"KLHL15","NA","NA","NA","K10452//kelch-like protein 15","gi|226442729|ref|NP_085127.2|//kelch-like protein 15 [Homo sapiens]"]
[253982,1476,11.65,5.21,-1.16097467726313,5.19591008528198e-6,"Down",7.00042e-7,"ASPHD1","GO:0031224//intrinsic component of membrane;GO:0031227//intrinsic component of endoplasmic reticulum membrane","GO:0016701//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen;GO:0016706//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors;GO:0016491//oxidoreductase activity","GO:0006464//cellular protein modification process;GO:0008152//metabolic process","K00476//aspartate beta-hydroxylase [EC:1.14.11.16]","gi|38708313|ref|NP_859069.2|//aspartate beta-hydroxylase domain-containing protein 1 [Homo sapiens];gi|297698509|ref|XP_002826363.1|//PREDICTED: aspartate beta-hydroxylase domain-containing protein 1 [Pongo abelii]"]
[2592,1407,17.23,7.71,-1.16011993630991,1.38410039921722e-8,"Down",1.31074e-9,"GALT","GO:0044444//cytoplasmic part","GO:0048029//monosaccharide binding;GO:0046914//transition metal ion binding;GO:0070569//uridylyltransferase activity","GO:0006011//UDP-glucose metabolic process;GO:0006012//galactose metabolic process","K00965//UDPglucose--hexose-1-phosphate uridylyltransferase [EC:2.7.7.12]","gi|119578834|gb|EAW58430.1|//hCG2040046, isoform CRA_c [Homo sapiens];gi|528763097|gb|EPY82756.1|//galactose-1-phosphate uridylyltransferase-like protein [Camelus ferus]"]
[26035,5206,16.46,7.37,-1.15922781132656,3.81698931192661e-14,"Down",2.0561e-15,"GLCE","GO:0031224//intrinsic component of membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0012505//endomembrane system","GO:0016857//racemase and epimerase activity, acting on carbohydrates and derivatives","GO:0030166//proteoglycan biosynthetic process;GO:0006024//glycosaminoglycan biosynthetic process","K01793//heparosan-N-sulfate-glucuronate 5-epimerase [EC:5.1.3.17]","gi|51317380|ref|NP_056369.1|//D-glucuronyl C5-epimerase [Homo sapiens];gi|530405674|ref|XP_005254356.1|//PREDICTED: D-glucuronyl C5-epimerase isoform X2 [Homo sapiens]"]
[124222,2642,17.06,7.64,-1.15897310328254,1.01299718867925e-18,"Down",3.9799e-20,"PAQR4","GO:0031224//intrinsic component of membrane","GO:0004871//signal transducer activity","NA","K06633//membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase [EC:2.7.11.1]","gi|530407613|ref|XP_005255169.1|//PREDICTED: progestin and adipoQ receptor family member 4 isoform X1 [Homo sapiens];gi|548962074|ref|NP_001271441.1|//progestin and adipoQ receptor family member 4 isoform 3 [Homo sapiens] ;gi|548961384|ref|NP_001271440.1|//progestin and adipoQ receptor family member 4 isoform 2 [Homo sapiens];gi|31542756|ref|NP_689554.2|//progestin and adipoQ receptor family member 4 isoform 1 [Homo sapiens]"]
[11162,1181,8.9,3.99,-1.15741658963141,0.000318673413492064,"Down",5.95298e-5,"NUDT6","GO:0043231//intracellular membrane-bounded organelle","GO:0005102//receptor binding;GO:0003824//catalytic activity","NA","NA","gi|20149583|ref|NP_009014.2|//nucleoside diphosphate-linked moiety X motif 6 isoform a [Homo sapiens]"]
[160897,8895,5.66,2.54,-1.15597355605972,2.31018410735931e-17,"Down",9.88978e-19,"GPR180","GO:0031224//intrinsic component of membrane","NA","NA","NA","gi|332216595|ref|XP_003257438.1|//PREDICTED: integral membrane protein GPR180 [Nomascus leucogenys]"]
[6720,3929,37.88,17.03,-1.15335789578984,7.113670908e-51,"Down",8.78882e-53,"SREBF1","GO:0012505//endomembrane system;GO:0030134//ER to Golgi transport vesicle;GO:0031224//intrinsic component of membrane;GO:0031090//organelle membrane","GO:0001071//nucleic acid binding transcription factor activity","GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0016125//sterol metabolic process;GO:0031669//cellular response to nutrient levels","K07197//sterol regulatory element-binding transcription factor 1","gi|22547195|ref|NP_004167.3|//sterol regulatory element-binding protein 1 isoform b [Homo sapiens];gi|635088242|ref|XP_008008733.1|//PREDICTED: sterol regulatory element-binding protein 1 isoform X2 [Chlorocebus sabaeus];gi|52630419|ref|NP_001005291.1|//sterol regulatory element-binding protein 1 isoform a [Homo sapiens];gi|62088798|dbj|BAD92846.1|//sterol regulatory element binding transcription factor 1 isoform a variant [Homo sapiens];gi|767992507|ref|XP_011522300.1|//PREDICTED: sterol regulatory element-binding protein 1 isoform X3 [Homo sapiens]"]
[3913,5693,37.49,16.86,-1.15290128934601,1.03621768588235e-70,"Down",8.70556e-73,"LAMB2","GO:0043256//laminin complex","NA","NA","K06243//laminin, beta 2","gi|119703755|ref|NP_002283.3|//laminin subunit beta-2 precursor [Homo sapiens]"]
[114908,3605,84.43,38.01,-1.15137668890977,1.76673833481481e-101,"Down",8.84024e-104,"TMEM123","GO:0031224//intrinsic component of membrane;GO:0009986//cell surface","GO:0004871//signal transducer activity","GO:0045793//positive regulation of cell size","NA","gi|27497569|gb|AAO13164.1|//keratinocytes associated transmembrane protein 3 [Homo sapiens]"]
[145553,760,17.72,7.98,-1.15091795233267,1.95315896505824e-5,"Down",2.90054e-6,"MDP1","NA","GO:0043169//cation binding;GO:0004721//phosphoprotein phosphatase activity","NA","K17619//magnesium-dependent phosphatase 1 [EC:3.1.3.48 3.1.3.-];K12194//charged multivesicular body protein 4","gi|33457311|ref|NP_612485.2|//magnesium-dependent phosphatase 1 isoform 1 [Homo sapiens];gi|315259107|ref|NP_001186750.1|//magnesium-dependent phosphatase 1 isoform 2 [Homo sapiens]"]
[55502,1470,18.28,8.25,-1.14780004592489,2.42449389200864e-9,"Down",2.08032e-10,"HES6","GO:0043231//intracellular membrane-bounded organelle;GO:0043234//protein complex","GO:0000989//transcription factor activity, transcription factor binding;GO:0001071//nucleic acid binding transcription factor activity;GO:0003676//nucleic acid binding","GO:0006355//regulation of transcription, DNA-templated;GO:0048731//system development;GO:0048869//cellular developmental process","K09087//hairy and enhancer of split 2/6/7","gi|21361763|ref|NP_061115.2|//transcription cofactor HES-6 isoform a [Homo sapiens];gi|218751874|ref|NP_001136325.1|//transcription cofactor HES-6 isoform b [Homo sapiens]"]
[57835,6364,2.08,0.94,-1.14585086646346,4.20610925205158e-5,"Down",6.64902e-6,"SLC4A5","NA","NA","NA","K13857//solute carrier family 4 (sodium bicarbonate cotransporter), member 5","gi|19743827|ref|NP_597812.1|//electrogenic sodium bicarbonate cotransporter 4 isoform c [Homo sapiens]"]
[2009,3931,7.39,3.34,-1.1457262616721,5.37545142589704e-10,"Down",4.25706e-11,"EML1","GO:0015630//microtubule cytoskeleton","GO:0046872//metal ion binding;GO:0005488//binding","NA","K18595//echinoderm microtubule-associated protein-like 1/2","gi|767979975|ref|XP_011534842.1|//PREDICTED: echinoderm microtubule-associated protein-like 1 isoform X3 [Homo sapiens];gi|530403238|ref|XP_005267457.1|//PREDICTED: echinoderm microtubule-associated protein-like 1 isoform X6 [Homo sapiens];gi|530403232|ref|XP_005267454.1|//PREDICTED: echinoderm microtubule-associated protein-like 1 isoform X2 [Homo sapiens];gi|21618448|gb|AAH32541.1|//Echinoderm microtubule associated protein like 1 [Homo sapiens] ;gi|56790932|ref|NP_001008707.1|//echinoderm microtubule-associated protein-like 1 isoform a [Homo sapiens];gi|767979973|ref|XP_005267456.2|//PREDICTED: echinoderm microtubule-associated protein-like 1 isoform X1 [Homo sapiens];gi|56790930|ref|NP_004425.2|//echinoderm microtubule-associated protein-like 1 isoform b [Homo sapiens];gi|530403234|ref|XP_005267455.1|//PREDICTED: echinoderm microtubule-associated protein-like 1 isoform X4 [Homo sapiens];gi|767979981|ref|XP_011534844.1|//PREDICTED: echinoderm microtubule-associated protein-like 1 isoform X7 [Homo sapiens]"]
[57664,3104,3.14,1.42,-1.14487362938695,0.00055872288524181,"Down",0.0001106194,"PLEKHA4","GO:0044424//intracellular part;GO:0044464//cell part","GO:0008289//lipid binding;GO:0035091//phosphatidylinositol binding","NA","K20642//Rho GTPase-activating protein 22/24/25;K17536//connector enhancer of kinase suppressor of Ras 2","gi|578834700|ref|XP_006723364.1|//PREDICTED: pleckstrin homology domain-containing family A member 4 isoform X8 [Homo sapiens];gi|238859651|ref|NP_065955.2|//pleckstrin homology domain-containing family A member 4 isoform 1 [Homo sapiens];gi|768010237|ref|XP_011525462.1|//PREDICTED: pleckstrin homology domain-containing family A member 4 isoform X5 [Homo sapiens];gi|530416938|ref|XP_005259164.1|//PREDICTED: pleckstrin homology domain-containing family A member 4 isoform X2 [Homo sapiens];gi|768010229|ref|XP_011525460.1|//PREDICTED: pleckstrin homology domain-containing family A member 4 isoform X3 [Homo sapiens];gi|238859653|ref|NP_001154826.1|//pleckstrin homology domain-containing family A member 4 isoform 2 [Homo sapiens];gi|768010242|ref|XP_011525463.1|//PREDICTED: pleckstrin homology domain-containing family A member 4 isoform X6 [Homo sapiens];gi|768010226|ref|XP_011525459.1|//PREDICTED: pleckstrin homology domain-containing family A member 4 isoform X1 [Homo sapiens]"]
[2690,4481,2.54,1.15,-1.14319463582779,0.000102516316757941,"Down",1.73457e-5,"GHR","GO:0043231//intracellular membrane-bounded organelle;GO:0044421//extracellular region part;GO:0044297//cell body;GO:0016021//integral component of membrane;GO:0043235//receptor complex","GO:0019904//protein domain specific binding;GO:0019902//phosphatase binding;GO:0042802//identical protein binding;GO:0019900//kinase binding;GO:0004896//cytokine receptor activity;GO:0042277//peptide binding","GO:0006790//sulfur compound metabolic process;GO:0072350//tricarboxylic acid metabolic process;GO:0043648//dicarboxylic acid metabolic process;GO:0034097//response to cytokine;GO:0042503//tyrosine phosphorylation of Stat3 protein;GO:0051216//cartilage development;GO:0043627//response to estrogen;GO:0043523//regulation of neuron apoptotic process;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0042506//tyrosine phosphorylation of Stat5 protein;GO:0001934//positive regulation of protein phosphorylation;GO:0000165//MAPK cascade;GO:0032868//response to insulin;GO:0035264//multicellular organism growth;GO:0031960//response to corticosteroid;GO:0014072//response to isoquinoline alkaloid;GO:0032787//monocarboxylic acid metabolic process;GO:0031667//response to nutrient levels;GO:0042976//activation of Janus kinase activity;GO:0006898//receptor-mediated endocytosis;GO:0009081//branched-chain amino acid metabolic process;GO:0014071//response to cycloalkane;GO:0006599//phosphagen metabolic process;GO:0045595//regulation of cell differentiation","K05080//growth hormone receptor","gi|334883127|ref|NP_001229328.1|//growth hormone receptor isoform 2 precursor [Homo sapiens];gi|426384835|ref|XP_004058950.1|//PREDICTED: growth hormone receptor [Gorilla gorilla gorilla];gi|767934402|ref|XP_011512333.1|//PREDICTED: growth hormone receptor isoform X1 [Homo sapiens]"]
[659,12086,5.08,2.3,-1.14319463582779,6.52251876923077e-21,"Down",2.25234e-22,"BMPR2","GO:0044459//plasma membrane part;GO:0016021//integral component of membrane","GO:0043169//cation binding;GO:0005515//protein binding;GO:0032559//adenyl ribonucleotide binding;GO:0004675//transmembrane receptor protein serine/threonine kinase activity","GO:0030282//bone mineralization;GO:0019229//regulation of vasoconstriction;GO:0003002//regionalization;GO:0010631//epithelial cell migration;GO:0001704//formation of primary germ layer;GO:0030509//BMP signaling pathway;GO:0006351//transcription, DNA-templated;GO:0016049//cell growth;GO:0003073//regulation of systemic arterial blood pressure;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0001934//positive regulation of protein phosphorylation;GO:0010594//regulation of endothelial cell migration;GO:0045597//positive regulation of cell differentiation;GO:0031669//cellular response to nutrient levels;GO:0001935//endothelial cell proliferation","K04671//bone morphogenetic protein receptor type-2 [EC:2.7.11.30]","gi|767919393|ref|XP_011509989.1|//PREDICTED: bone morphogenetic protein receptor type-2 isoform X1 [Homo sapiens];gi|332209807|ref|XP_003254004.1|//PREDICTED: bone morphogenetic protein receptor type-2 [Nomascus leucogenys]"]
[8676,4501,2.23,1.01,-1.14268841716851,0.000536949825493267,"Down",0.0001059106,"STX11","GO:0043231//intracellular membrane-bounded organelle","GO:0005515//protein binding","GO:0015031//protein transport","K08487//syntaxin 11","gi|767943789|ref|XP_011534515.1|//PREDICTED: syntaxin-11 isoform X2 [Homo sapiens];gi|694918717|ref|XP_009450439.1|//PREDICTED: uncharacterized protein LOC104007012 [Pan troglodytes]"]
[175,2113,13.01,5.9,-1.14083410246859,1.75540291411765e-9,"Down",1.474764e-10,"AGA","GO:0005856//cytoskeleton;GO:0000323//lytic vacuole","GO:0005515//protein binding;GO:0004067//asparaginase activity","GO:0006464//cellular protein modification process;GO:0006530//asparagine catabolic process","K01444//N4-(beta-N-acetylglucosaminyl)-L-asparaginase [EC:3.5.1.26]","gi|285002253|ref|NP_001165459.1|//N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform 2 precursor [Homo sapiens];gi|285002251|ref|NP_000018.2|//N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform 1 preproprotein [Homo sapiens]"]
[51226,932,61.4,27.87,-1.13952565315373,1.49550896448598e-18,"Down",5.93104e-20,"COPZ2","GO:0030120//vesicle coat;GO:0044431//Golgi apparatus part","NA","GO:0006810//transport;GO:0015031//protein transport","K20472//coatomer subunit zeta","gi|831220623|ref|XP_012658701.1|//PREDICTED: coatomer subunit zeta-2 isoform X1 [Otolemur garnettii];gi|593727064|ref|XP_007109500.1|//PREDICTED: coatomer subunit zeta-2 isoform X1 [Physeter catodon];gi|795583253|ref|XP_011723728.1|//PREDICTED: coatomer subunit zeta-2 isoform X2 [Macaca nemestrina];gi|675660470|ref|XP_008995690.1|//PREDICTED: coatomer subunit zeta-2 isoform X2 [Callithrix jacchus];gi|767994952|ref|XP_011523176.1|//PREDICTED: coatomer subunit zeta-2 isoform X1 [Homo sapiens]"]
[57409,1520,22.29,10.13,-1.13776244245861,1.04824060649652e-7,"Down",1.116362e-8,"MIF4GD","GO:0043231//intracellular membrane-bounded organelle;GO:0044424//intracellular part","GO:0005515//protein binding","GO:0044260//cellular macromolecule metabolic process;GO:0044238//primary metabolic process;GO:0006412//translation","NA","gi|119609670|gb|EAW89264.1|//MIF4G domain containing, isoform CRA_b [Homo sapiens];gi|675722515|ref|XP_008964123.1|//PREDICTED: MIF4G domain-containing protein isoform X1 [Pan paniscus];gi|821013565|ref|XP_012367934.1|//PREDICTED: MIF4G domain-containing protein [Nomascus leucogenys];gi|675722540|ref|XP_008964131.1|//PREDICTED: MIF4G domain-containing protein isoform X8 [Pan paniscus];gi|795506367|ref|XP_011897909.1|//PREDICTED: MIF4G domain-containing protein isoform X1 [Cercocebus atys];gi|767995378|ref|XP_011523353.1|//PREDICTED: MIF4G domain-containing protein isoform X3 [Homo sapiens];gi|767995380|ref|XP_011523354.1|//PREDICTED: MIF4G domain-containing protein isoform X4 [Homo sapiens];gi|767995388|ref|XP_011523357.1|//PREDICTED: MIF4G domain-containing protein isoform X7 [Homo sapiens];gi|767995384|ref|XP_011523356.1|//PREDICTED: MIF4G domain-containing protein isoform X6 [Homo sapiens]"]
[30008,2096,27.5,12.5,-1.13750352374993,4.63231741449275e-19,"Down",1.777038e-20,"EFEMP2","GO:0044464//cell part;GO:0005578//proteinaceous extracellular matrix","GO:0046872//metal ion binding;GO:0004872//receptor activity;GO:0005198//structural molecule activity","GO:0007599//hemostasis","K19866//EGF-containing fibulin-like extracellular matrix protein 2","gi|795556420|ref|XP_011719178.1|//PREDICTED: EGF-containing fibulin-like extracellular matrix protein 2 [Macaca nemestrina]"]
[65990,867,33.91,15.42,-1.1369080191104,1.20141879370787e-9,"Down",9.90792e-11,"FAM173A","GO:0031224//intrinsic component of membrane","NA","NA","K09573//FK506-binding protein 7 [EC:5.2.1.8]","gi|685611097|ref|XP_009193878.1|//PREDICTED: protein FAM173A isoform X3 [Papio anubis];gi|404351626|ref|NP_001258214.1|//protein FAM173A isoform 2 [Homo sapiens];gi|13027600|ref|NP_076422.1|//protein FAM173A isoform 1 [Homo sapiens]"]
[144233,3266,3.12,1.42,-1.13565509935757,0.000413723860366442,"Down",7.95092e-5,"BCDIN3D","NA","GO:0016741//transferase activity, transferring one-carbon groups","GO:0006730//one-carbon metabolic process","K17985//activating molecule in BECN1-regulated autophagy protein 1;K01064//wingless-type MMTV integration site family, member 9","gi|32171233|ref|NP_859059.1|//pre-miRNA 5'-monophosphate methyltransferase [Homo sapiens]"]
[400569,870,23.57,10.73,-1.13530168249365,3.14744232104121e-7,"Down",3.5853e-8,"MED11","GO:0043231//intracellular membrane-bounded organelle;GO:0043234//protein complex","GO:0005488//binding","GO:0006355//regulation of transcription, DNA-templated","K15131//mediator of RNA polymerase II transcription subunit 11","gi|6841242|gb|AAF28974.1|AF161414_1//HSPC296 [Homo sapiens];gi|119610824|gb|EAW90418.1|//similar to HSPC296, isoform CRA_b, partial [Homo sapiens]"]
[6709,7889,26.06,11.87,-1.13451714892623,1.36503244634483e-67,"Down",1.222694e-69,"SPTAN1","GO:0030864//cortical actin cytoskeleton;GO:0043227//membrane-bounded organelle","GO:0046872//metal ion binding;GO:0008092//cytoskeletal protein binding;GO:0005198//structural molecule activity","GO:0030835//negative regulation of actin filament depolymerization;GO:0006935//chemotaxis;GO:0006915//apoptotic process","K06114//spectrin alpha","gi|578817805|ref|XP_006717312.1|//PREDICTED: spectrin alpha chain, non-erythrocytic 1 isoform X5 [Homo sapiens];gi|578817803|ref|XP_006717311.1|//PREDICTED: spectrin alpha chain, non-erythrocytic 1 isoform X4 [Homo sapiens];gi|578817801|ref|XP_006717310.1|//PREDICTED: spectrin alpha chain, non-erythrocytic 1 isoform X3 [Homo sapiens];gi|578817797|ref|XP_006717308.1|//PREDICTED: spectrin alpha chain, non-erythrocytic 1 isoform X1 [Homo sapiens];gi|62089306|dbj|BAD93097.1|//spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) variant [Homo sapiens];gi|578817811|ref|XP_006717315.1|//PREDICTED: spectrin alpha chain, non-erythrocytic 1 isoform X8 [Homo sapiens];gi|578817799|ref|XP_006717309.1|//PREDICTED: spectrin alpha chain, non-erythrocytic 1 isoform X2 [Homo sapiens];gi|578817807|ref|XP_006717313.1|//PREDICTED: spectrin alpha chain, non-erythrocytic 1 isoform X6 [Homo sapiens];gi|578817813|ref|XP_006717316.1|//PREDICTED: spectrin alpha chain, non-erythrocytic 1 isoform X9 [Homo sapiens]"]
[100129792,3491,2.8,1.28,-1.12928301694497,0.000548440736230072,"Down",0.0001083804,"CCDC152","NA","NA","NA","K01064//wingless-type MMTV integration site family, member 9;K12025//tripartite motif-containing protein 52","gi|71052195|gb|AAH39102.1|//CCDC152 protein, partial [Homo sapiens]"]
[135293,4672,19.11,8.74,-1.12862259347686,5.10250538745387e-15,"Down",2.5626e-16,"PM20D2","NA","GO:0003824//catalytic activity","NA","K12581//CCR4-NOT transcription complex subunit 7/8;K15696//RING finger protein 113B;K17985//activating molecule in BECN1-regulated autophagy protein 1;K12025//tripartite motif-containing protein 52","gi|634826332|ref|XP_007949644.1|//PREDICTED: peptidase M20 domain-containing protein 2 [Orycteropus afer afer];gi|58082085|ref|NP_001010853.1|//peptidase M20 domain-containing protein 2 [Homo sapiens];gi|724965692|ref|XP_010356076.1|//PREDICTED: peptidase M20 domain-containing protein 2 [Rhinopithecus roxellana]"]
[81488,4320,10.8,4.94,-1.12844836546615,1.19822908453608e-15,"Down",5.74392e-17,"POLR2M","GO:0043231//intracellular membrane-bounded organelle;GO:0012505//endomembrane system;GO:0044297//cell body","GO:0034062//5'-3' RNA polymerase activity","GO:0051657//maintenance of organelle location;GO:0010467//gene expression","NA","gi|21915167|ref|NP_056347.1|//protein GRINL1A isoform 1 [Homo sapiens];gi|70166832|ref|NP_001018112.1|//protein GRINL1A isoform 2 [Homo sapiens]"]
[54985,760,33.01,15.1,-1.12835458901009,4.53636908280255e-7,"Down",5.27954e-8,"HCFC1R1","GO:0043231//intracellular membrane-bounded organelle","NA","NA","NA","gi|817343702|ref|XP_012297321.1|//PREDICTED: host cell factor C1 regulator 1 isoform X1 [Aotus nancymaae];gi|50952466|ref|NP_001002017.1|//host cell factor C1 regulator 1 isoform 2 [Homo sapiens];gi|8923536|ref|NP_060355.1|//host cell factor C1 regulator 1 isoform 1 [Homo sapiens];gi|958815888|ref|XP_014688662.1|//PREDICTED: host cell factor C1 regulator 1 isoform X1 [Equus asinus];gi|568815696|ref|NP_001275596.1|//host cell factor C1 regulator 1 isoform 3 [Homo sapiens]"]
[55616,4127,15.9,7.28,-1.12701640997302,1.62988045906542e-21,"Down",5.38662e-23,"ASAP3","GO:0044424//intracellular part","GO:0046914//transition metal ion binding","GO:0032012//regulation of ARF protein signal transduction","K12488//Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein","gi|767905076|ref|XP_011540056.1|//PREDICTED: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X1 [Homo sapiens];gi|767905080|ref|XP_011540058.1|//PREDICTED: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X3 [Homo sapiens];gi|767905082|ref|XP_011540059.1|//PREDICTED: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X4 [Homo sapiens];gi|767905078|ref|XP_011540057.1|//PREDICTED: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X2 [Homo sapiens];gi|675709525|ref|XP_008961364.1|//PREDICTED: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform X3 [Pan paniscus];gi|19923540|ref|NP_060177.2|//arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform a [Homo sapiens];gi|221307473|ref|NP_001137250.1|//arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 isoform b [Homo sapiens] "]
[253827,4393,10.11,4.63,-1.12669889864278,1.91555590505288e-14,"Down",1.007004e-15,"MSRB3","GO:0043231//intracellular membrane-bounded organelle","GO:0016671//oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor;GO:0046914//transition metal ion binding","GO:0044267//cellular protein metabolic process","K07305//peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12]","gi|431892020|gb|ELK02467.1|//Methionine-R-sulfoxide reductase B3, mitochondrial [Pteropus alecto];gi|675780409|ref|XP_003824841.2|//PREDICTED: methionine-R-sulfoxide reductase B3 isoform X1 [Pan paniscus]"]
[92597,5075,7.23,3.32,-1.12281240560419,1.20180779340659e-13,"Down",6.7559e-15,"MOB1B","GO:0043231//intracellular membrane-bounded organelle","GO:0043169//cation binding;GO:0019899//enzyme binding;GO:0008047//enzyme activator activity;GO:0016772//transferase activity, transferring phosphorus-containing groups","GO:0019222//regulation of metabolic process;GO:0006468//protein phosphorylation;GO:0035556//intracellular signal transduction","K06685//MOB kinase activator 1","gi|971393650|ref|XP_015131897.1|//PREDICTED: MOB kinase activator 1B [Gallus gallus];gi|348041379|ref|NP_001231695.1|//MOB kinase activator 1B isoform 1 [Homo sapiens] ;gi|348041385|ref|NP_001231696.1|//MOB kinase activator 1B isoform 3 [Homo sapiens];gi|591321776|ref|XP_007087031.1|//PREDICTED: MOB kinase activator 1B [Panthera tigris altaica];gi|767933057|ref|XP_011530714.1|//PREDICTED: MOB kinase activator 1B isoform X2 [Homo sapiens]"]
[84513,1534,19.17,8.83,-1.11836499401968,0.000265864478600269,"Down",4.88108e-5,"PLPP5","GO:0031224//intrinsic component of membrane","GO:0016791//phosphatase activity","NA","K12581//CCR4-NOT transcription complex subunit 7/8;K02927//large subunit ribosomal protein L40e;K17985//activating molecule in BECN1-regulated autophagy protein 1;K01080//phosphatidate phosphatase [EC:3.1.3.4]","gi|767951277|ref|XP_011542974.1|//PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X5 [Homo sapiens];gi|332240917|ref|XP_003269634.1|//PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X2 [Nomascus leucogenys];gi|156523239|ref|NP_001096030.1|//phospholipid phosphatase 5 isoform 3 [Homo sapiens] ;gi|767951282|ref|XP_011542976.1|//PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X6 [Homo sapiens];gi|767951271|ref|XP_011542972.1|//PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X2 [Homo sapiens];gi|685557666|ref|XP_009211157.1|//PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X1 [Papio anubis];gi|795316756|ref|XP_011926077.1|//PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X3 [Cercocebus atys];gi|694926490|ref|XP_519712.3|//PREDICTED: phosphatidate phosphatase PPAPDC1B isoform X1 [Pan troglodytes]"]
[9240,2666,34.54,15.91,-1.11833424719788,1.7835846848329e-29,"Down",4.28598e-31,"PNMA1","GO:0031981//nuclear lumen;GO:0005924//cell-substrate adherens junction","GO:0005488//binding","GO:0007399//nervous system development;GO:0012501//programmed cell death;GO:0048232//male gamete generation;GO:0006954//inflammatory response","K17561//coiled-coil domain-containing protein 8;K02183//calmodulin","gi|52486265|ref|NP_006020.4|//paraneoplastic antigen Ma1 [Homo sapiens]"]
[284611,5359,6.37,2.94,-1.11547721741994,2.69917026355476e-11,"Down",1.857472e-12,"FAM102B","NA","NA","NA","NA","gi|162809336|ref|NP_001010883.2|//protein FAM102B [Homo sapiens]"]
[4281,4911,4.31,1.99,-1.11491943854545,1.55799526132879e-7,"Down",1.694854e-8,"MID1","GO:0005874//microtubule","GO:0046914//transition metal ion binding;GO:0003824//catalytic activity;GO:0019899//enzyme binding","GO:0032872//regulation of stress-activated MAPK cascade;GO:0007275//multicellular organism development;GO:0007019//microtubule depolymerization","K08285//midline 1 [EC:2.3.2.27]","gi|300797175|ref|NP_001180208.1|//E3 ubiquitin-protein ligase Midline-1 isoform 4 [Homo sapiens];gi|530421144|ref|XP_005274593.1|//PREDICTED: E3 ubiquitin-protein ligase Midline-1 isoform X2 [Homo sapiens];gi|578837904|ref|XP_006724556.1|//PREDICTED: E3 ubiquitin-protein ligase Midline-1 isoform X3 [Homo sapiens];gi|641758954|ref|XP_008165408.1|//PREDICTED: E3 ubiquitin-protein ligase Midline-1 isoform X4 [Chrysemys picta bellii];gi|300797197|ref|NP_001180209.1|//E3 ubiquitin-protein ligase Midline-1 isoform 5 [Homo sapiens];gi|4557753|ref|NP_000372.1|//E3 ubiquitin-protein ligase Midline-1 isoform 1 [Homo sapiens];gi|300797111|ref|NP_150631.1|//E3 ubiquitin-protein ligase Midline-1 isoform 2 [Homo sapiens] ;gi|300797215|ref|NP_001180210.1|//E3 ubiquitin-protein ligase Midline-1 isoform 6 [Homo sapiens];gi|300797153|ref|NP_001180207.1|//E3 ubiquitin-protein ligase Midline-1 isoform 3 [Homo sapiens] "]
[3188,2390,9.42,4.35,-1.11471165887669,9.26774373302108e-8,"Down",9.77842e-9,"HNRNPH2","GO:0031981//nuclear lumen;GO:0005856//cytoskeleton;GO:0030529//intracellular ribonucleoprotein complex","GO:0003676//nucleic acid binding","GO:0000377//RNA splicing, via transesterification reactions with bulged adenosine as nucleophile","K12898//heterogeneous nuclear ribonucleoprotein F/H","gi|148688440|gb|EDL20387.1|//heterogeneous nuclear ribonucleoprotein H2, isoform CRA_b, partial [Mus musculus]"]
[51084,1462,8.25,3.81,-1.11460312163986,0.000269108920617864,"Down",4.95062e-5,"CRYL1","GO:0044444//cytoplasmic part","GO:0016616//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0042802//identical protein binding;GO:0051287//NAD binding","GO:0032787//monocarboxylic acid metabolic process","K13247//L-gulonate 3-dehydrogenase [EC:1.1.1.45]","gi|530402420|ref|XP_005266473.1|//PREDICTED: lambda-crystallin homolog isoform X3 [Homo sapiens];gi|852727258|ref|XP_012866259.1|//PREDICTED: lambda-crystallin homolog [Dipodomys ordii];gi|115430219|ref|NP_057058.2|//lambda-crystallin homolog [Homo sapiens];gi|119628666|gb|EAX08261.1|//crystallin, lambda 1, isoform CRA_c [Homo sapiens]"]
[3489,980,142.39,65.93,-1.11084084342042,3.78676769747899e-42,"Down",5.5674e-44,"IGFBP6","GO:0043231//intracellular membrane-bounded organelle;GO:0044424//intracellular part;GO:0044421//extracellular region part;GO:0005576//extracellular region","GO:0005520//insulin-like growth factor binding","GO:0008283//cell proliferation;GO:0023052//signaling;GO:0009987//cellular process;GO:0016049//cell growth;GO:0065007//biological regulation","K10138//insulin-like growth factor-binding protein 3;K00637//sterol O-acyltransferase [EC:2.3.1.26]","gi|635065540|ref|XP_008001559.1|//PREDICTED: insulin-like growth factor-binding protein 6 isoform X1 [Chlorocebus sabaeus];gi|426372702|ref|XP_004053257.1|//PREDICTED: insulin-like growth factor-binding protein 6 [Gorilla gorilla gorilla]"]
[112464,1039,114.12,52.88,-1.10975757007403,1.43832031836735e-36,"Down",2.61222e-38,"CAVIN3","NA","NA","NA","K19387//polymerase I and transcript release factor","gi|47132587|ref|NP_659477.2|//protein kinase C delta-binding protein [Homo sapiens]"]
[114112,2919,8.61,3.99,-1.1096244911745,4.35042858399511e-8,"Down",4.39934e-9,"TXNRD3","GO:0043231//intracellular membrane-bounded organelle","GO:0015036//disulfide oxidoreductase activity;GO:0016209//antioxidant activity;GO:0000166//nucleotide binding;GO:0050662//coenzyme binding","GO:0006790//sulfur compound metabolic process;GO:0019725//cellular homeostasis;GO:0048232//male gamete generation;GO:0006091//generation of precursor metabolites and energy;GO:0051234//establishment of localization;GO:0048869//cellular developmental process","K00384//thioredoxin reductase (NADPH) [EC:1.8.1.9]","gi|29476880|gb|AAH50032.1|//TXNRD3 protein, partial [Homo sapiens]"]
[23233,4684,10.94,5.07,-1.10955508578922,1.13145543576159e-13,"Down",6.33246e-15,"EXOC6B","GO:0043234//protein complex","NA","GO:0006887//exocytosis","K19985//exocyst complex component 6","gi|767914204|ref|XP_011531013.1|//PREDICTED: exocyst complex component 6B isoform X3 [Homo sapiens];gi|4589470|dbj|BAA76763.1|//KIAA0919 protein [Homo sapiens];gi|675695957|ref|XP_008958526.1|//PREDICTED: exocyst complex component 6B isoform X1 [Pan paniscus];gi|586981970|ref|XP_006930245.1|//PREDICTED: exocyst complex component 6B isoform X1 [Felis catus];gi|767914202|ref|XP_011531012.1|//PREDICTED: exocyst complex component 6B isoform X2 [Homo sapiens];gi|149363656|ref|NP_056004.1|//exocyst complex component 6B [Homo sapiens];gi|731493177|ref|XP_010591950.1|//PREDICTED: exocyst complex component 6B isoform X4 [Loxodonta africana]"]
[7485,1514,18.14,8.42,-1.10728231746213,6.3629632e-9,"Down",5.77808e-10,"WRB","GO:0031981//nuclear lumen;GO:0031224//intrinsic component of membrane","NA","NA","NA","gi|635023560|ref|XP_007966559.1|//PREDICTED: tail-anchored protein insertion receptor WRB [Chlorocebus sabaeus];gi|111494096|gb|AAI11394.1|//WRB protein, partial [Homo sapiens]"]
[2199,4193,13.59,6.34,-1.09999071062798,3.44207947810107e-18,"Down",1.388484e-19,"FBLN2","GO:0031012//extracellular matrix","GO:0046872//metal ion binding;GO:0005198//structural molecule activity","NA","K17307//fibulin 1/2","gi|578805783|ref|XP_006713089.1|//PREDICTED: fibulin-2 isoform X1 [Homo sapiens];gi|51873053|ref|NP_001004019.1|//fibulin-2 isoform a precursor [Homo sapiens];gi|221045154|dbj|BAH14254.1|//unnamed protein product [Homo sapiens]"]
[65989,1808,18.41,8.61,-1.09640448395306,8.81623219136213e-9,"Down",8.19646e-10,"DLK2","GO:0016020//membrane;GO:0031224//intrinsic component of membrane","GO:0046872//metal ion binding","GO:0045595//regulation of cell differentiation","K06051//delta","gi|767940544|ref|XP_011513124.1|//PREDICTED: protein delta homolog 2 isoform X2 [Homo sapiens];gi|530382414|ref|XP_005249365.1|//PREDICTED: protein delta homolog 2 isoform X1 [Homo sapiens];gi|767940546|ref|XP_011513125.1|//PREDICTED: protein delta homolog 2 isoform X3 [Homo sapiens];gi|558178155|ref|XP_006100638.1|//PREDICTED: protein delta homolog 2 [Myotis lucifugus]"]
[3953,3596,11.33,5.3,-1.09608359636995,1.80892168862974e-17,"Down",7.66568e-19,"LEPR","GO:0031224//intrinsic component of membrane","GO:0004888//transmembrane signaling receptor activity;GO:0005488//binding","GO:0007165//signal transduction;GO:0007166//cell surface receptor signaling pathway;GO:0032501//multicellular organismal process;GO:0015980//energy derivation by oxidation of organic compounds","K05062//leptin receptor","gi|40254464|ref|NP_002294.2|//leptin receptor isoform 1 precursor [Homo sapiens];gi|51093381|ref|NP_001003680.1|//leptin receptor isoform 2 precursor [Homo sapiens];gi|51093379|ref|NP_001003679.1|//leptin receptor isoform 3 precursor [Homo sapiens];gi|310923189|ref|NP_001185617.1|//leptin receptor isoform 4 precursor [Homo sapiens]"]
[2180,3881,6.84,3.2,-1.09592441999854,1.05579458339921e-8,"Down",9.90052e-10,"ACSL1","GO:0031224//intrinsic component of membrane;GO:0044439//peroxisomal part;GO:0031966//mitochondrial membrane","GO:0015645//fatty acid ligase activity;GO:0032559//adenyl ribonucleotide binding","GO:0019217//regulation of fatty acid metabolic process;GO:0035336//long-chain fatty-acyl-CoA metabolic process;GO:0006641//triglyceride metabolic process;GO:0032501//multicellular organismal process","K01897//long-chain acyl-CoA synthetase [EC:6.2.1.3]","gi|557878740|ref|NP_001273640.1|//long-chain-fatty-acid--CoA ligase 1 isoform c [Homo sapiens];gi|40807491|ref|NP_001986.2|//long-chain-fatty-acid--CoA ligase 1 isoform a [Homo sapiens];gi|557878738|ref|NP_001273639.1|//long-chain-fatty-acid--CoA ligase 1 isoform b [Homo sapiens] "]
[7266,1966,39.88,18.66,-1.09571642354644,1.74786938054475e-22,"Down",5.54982e-24,"DNAJC7","GO:0031981//nuclear lumen;GO:0043232//intracellular non-membrane-bounded organelle","GO:0005515//protein binding","GO:0042026//protein refolding","K09527//DnaJ homolog subfamily C member 7","gi|472382377|ref|XP_004410574.1|//PREDICTED: dnaJ homolog subfamily C member 7 isoform X1 [Odobenus rosmarus divergens];gi|674054226|ref|XP_008833499.1|//PREDICTED: dnaJ homolog subfamily C member 7 [Nannospalax galili];gi|821039125|ref|XP_012359196.1|//PREDICTED: dnaJ homolog subfamily C member 7 isoform X1 [Nomascus leucogenys];gi|767995712|ref|XP_011523468.1|//PREDICTED: dnaJ homolog subfamily C member 7 isoform X2 [Homo sapiens];gi|564374216|ref|XP_006247373.1|//PREDICTED: dnaJ homolog subfamily C member 7 isoform X1 [Rattus norvegicus]"]
[118980,2585,5.44,2.55,-1.09310940439148,6.91290701649176e-5,"Down",1.13934e-5,"SFXN2","GO:0031224//intrinsic component of membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0019866//organelle inner membrane","GO:0015075//ion transmembrane transporter activity","GO:0000041//transition metal ion transport","K03351//anaphase-promoting complex subunit 4;K17985//activating molecule in BECN1-regulated autophagy protein 1;K01064//wingless-type MMTV integration site family, member 9","gi|724960626|ref|XP_010354481.1|//PREDICTED: sideroflexin-2 isoform X1 [Rhinopithecus roxellana];gi|724960628|ref|XP_010354482.1|//PREDICTED: sideroflexin-2 isoform X2 [Rhinopithecus roxellana];gi|817337370|ref|XP_012294969.1|//PREDICTED: sideroflexin-2 isoform X1 [Aotus nancymaae];gi|767961551|ref|XP_011537563.1|//PREDICTED: sideroflexin-2 isoform X2 [Homo sapiens];gi|694941527|ref|XP_009457412.1|//PREDICTED: sideroflexin-2 isoform X1 [Pan troglodytes]"]
[9912,4114,3.84,1.8,-1.09310940439148,1.89638947771762e-5,"Down",2.81272e-6,"ARHGAP44","GO:0044444//cytoplasmic part","GO:0008047//enzyme activator activity","GO:0035556//intracellular signal transduction;GO:0009966//regulation of signal transduction","K21067//Rho GTPase-activating protein 44","gi|119610374|gb|EAW89968.1|//KIAA0672 gene product, isoform CRA_d [Homo sapiens];gi|530410838|ref|XP_005256948.1|//PREDICTED: rho GTPase-activating protein 44 isoform X4 [Homo sapiens];gi|884896050|ref|XP_013004101.1|//PREDICTED: rho GTPase-activating protein 44 [Cavia porcellus];gi|929654082|dbj|BAA31647.3|//KIAA0672 protein [Homo sapiens];gi|219518027|gb|AAI43854.1|//RICH2 protein [Homo sapiens]"]
[5159,5808,8.84,4.15,-1.09093503315714,4.58762780952381e-16,"Down",2.14248e-17,"PDGFRB","GO:0016021//integral component of membrane","GO:0070851//growth factor receptor binding;GO:0032559//adenyl ribonucleotide binding;GO:0005017//platelet-derived growth factor-activated receptor activity;GO:0019838//growth factor binding;GO:0004930//G-protein coupled receptor activity","GO:0016477//cell migration;GO:0043009//chordate embryonic development;GO:0060537//muscle tissue development;GO:0035270//endocrine system development;GO:0001932//regulation of protein phosphorylation;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0009887//animal organ morphogenesis;GO:0008283//cell proliferation;GO:0006935//chemotaxis;GO:0048871//multicellular organismal homeostasis","K05089//platelet-derived growth factor receptor beta [EC:2.7.10.1]","gi|4505683|ref|NP_002600.1|//platelet-derived growth factor receptor beta precursor [Homo sapiens];gi|931571609|ref|XP_014200561.1|//PREDICTED: platelet-derived growth factor receptor beta isoform X3 [Pan paniscus]"]
[51582,4295,56.46,26.52,-1.09014835333711,7.19331547317073e-73,"Down",5.46564e-75,"AZIN1","GO:0044444//cytoplasmic part","GO:0004857//enzyme inhibitor activity;GO:0005488//binding;GO:0008047//enzyme activator activity","GO:0006595//polyamine metabolic process;GO:0006520//cellular amino acid metabolic process","K01581//ornithine decarboxylase [EC:4.1.1.17];K01583//arginine decarboxylase [EC:4.1.1.19]","gi|677283305|ref|NP_001288597.1|//antizyme inhibitor 1 isoform 2 [Homo sapiens] ;gi|21361583|ref|NP_056962.2|//antizyme inhibitor 1 isoform 1 [Homo sapiens];gi|2641952|dbj|BAA23593.1|//antizyme inhibitor [Homo sapiens];gi|530389129|ref|XP_005251026.1|//PREDICTED: antizyme inhibitor 1 isoform X2 [Homo sapiens]"]
[54664,6351,14.25,6.7,-1.08872891859433,5.82027193220339e-28,"Down",1.48491e-29,"TMEM106B","GO:0031224//intrinsic component of membrane","NA","NA","NA","gi|40254893|ref|NP_060844.2|//transmembrane protein 106B [Homo sapiens];gi|20380426|gb|AAH28108.1|//TMEM106B protein, partial [Homo sapiens];gi|743700658|ref|XP_010970352.1|//PREDICTED: transmembrane protein 106B [Camelus bactrianus]"]
[114822,3987,7.27,3.42,-1.0879590390337,5.33530791792066e-9,"Down",4.81852e-10,"RHPN1","GO:0044464//cell part","NA","GO:0023052//signaling","K18040//tyrosine-protein phosphatase non-receptor type 23 [EC:3.1.3.48]","gi|530388717|ref|XP_005250829.1|//PREDICTED: rhophilin-1 isoform X3 [Homo sapiens];gi|119120915|ref|NP_443156.2|//rhophilin-1 [Homo sapiens];gi|767952458|ref|XP_011515125.1|//PREDICTED: rhophilin-1 isoform X9 [Homo sapiens];gi|767952450|ref|XP_011515121.1|//PREDICTED: rhophilin-1 isoform X6 [Homo sapiens];gi|578815820|ref|XP_006716565.1|//PREDICTED: rhophilin-1 isoform X2 [Homo sapiens];gi|767952452|ref|XP_011515122.1|//PREDICTED: rhophilin-1 isoform X7 [Homo sapiens];gi|530388719|ref|XP_005250830.1|//PREDICTED: rhophilin-1 isoform X4 [Homo sapiens];gi|767952443|ref|XP_011515119.1|//PREDICTED: rhophilin-1 isoform X1 [Homo sapiens];gi|119602657|gb|EAW82251.1|//rhophilin, Rho GTPase binding protein 1, isoform CRA_a [Homo sapiens];gi|767952448|ref|XP_011515120.1|//PREDICTED: rhophilin-1 isoform X5 [Homo sapiens]"]
[4595,1930,13.58,6.4,-1.08533966935737,1.53996356151949e-6,"Down",1.928284e-7,"MUTYH","GO:0031981//nuclear lumen","GO:0043169//cation binding;GO:0016799//hydrolase activity, hydrolyzing N-glycosyl compounds;GO:0032404//mismatch repair complex binding;GO:0051536//iron-sulfur cluster binding;GO:0004518//nuclease activity","GO:0006285//base-excision repair, AP site formation","K03575//A/G-specific adenine glycosylase [EC:3.2.2.-]","gi|767904442|ref|XP_011539809.1|//PREDICTED: A/G-specific adenine DNA glycosylase isoform X6 [Homo sapiens];gi|645066007|ref|NP_001280119.1|//adenine DNA glycosylase isoform 6 [Homo sapiens];gi|767904421|ref|XP_011539799.1|//PREDICTED: A/G-specific adenine DNA glycosylase isoform X2 [Homo sapiens];gi|6912520|ref|NP_036354.1|//adenine DNA glycosylase isoform 1 [Homo sapiens];gi|190358497|ref|NP_001121897.1|//adenine DNA glycosylase isoform 5 [Homo sapiens];gi|767904438|ref|XP_011539807.1|//PREDICTED: A/G-specific adenine DNA glycosylase isoform X5 [Homo sapiens];gi|767904433|ref|XP_011539805.1|//PREDICTED: A/G-specific adenine DNA glycosylase isoform X4 [Homo sapiens];gi|115298652|ref|NP_001041638.1|//adenine DNA glycosylase isoform 4 [Homo sapiens];gi|115298648|ref|NP_001041636.1|//adenine DNA glycosylase isoform 2 [Homo sapiens];gi|635108570|ref|XP_007977151.1|//PREDICTED: A/G-specific adenine DNA glycosylase isoform X4 [Chlorocebus sabaeus]"]
[1528,852,53.92,25.42,-1.0848564661769,6.23014026546682e-14,"Down",3.42142e-15,"CYB5A","GO:0031224//intrinsic component of membrane;GO:0031966//mitochondrial membrane","GO:0016616//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0005515//protein binding;GO:0005506//iron ion binding;GO:0015002//heme-copper terminal oxidase activity","GO:0006766//vitamin metabolic process;GO:0006091//generation of precursor metabolites and energy;GO:0051234//establishment of localization","K10226//acyl-CoA 6-desaturase (Delta-6 desaturase) [EC:1.14.19.3]","gi|62088814|dbj|BAD92854.1|//cytochrome b-5 isoform 1 variant [Homo sapiens];gi|982309480|ref|XP_015295106.1|//PREDICTED: cytochrome b5 type B isoform X5 [Macaca fascicularis]"]
[1490,2358,4.61,2.18,-1.08043861565241,0.000621006275725757,"Down",0.0001242166,"CTGF","GO:0031012//extracellular matrix;GO:0016020//membrane;GO:0044431//Golgi apparatus part","GO:0005539//glycosaminoglycan binding;GO:0005102//receptor binding;GO:0019838//growth factor binding","GO:0001101//response to acid chemical;GO:0009746//response to hexose;GO:0009888//tissue development;GO:0006950//response to stress;GO:0016049//cell growth;GO:0030323//respiratory tube development;GO:0006259//DNA metabolic process;GO:0043627//response to estrogen;GO:0048869//cellular developmental process;GO:0001932//regulation of protein phosphorylation;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0008283//cell proliferation;GO:0048870//cell motility;GO:0045989//positive regulation of striated muscle contraction;GO:0033993//response to lipid;GO:0016337//single organismal cell-cell adhesion;GO:0008219//cell death;GO:0031589//cell-substrate adhesion;GO:0006816//calcium ion transport;GO:0032940//secretion by cell;GO:0007568//aging;GO:0031960//response to corticosteroid;GO:0010557//positive regulation of macromolecule biosynthetic process;GO:0010467//gene expression;GO:0048646//anatomical structure formation involved in morphogenesis;GO:0010952//positive regulation of peptidase activity;GO:0045787//positive regulation of cell cycle;GO:0006629//lipid metabolic process","K06827//connective tissue growth factor","gi|4503123|ref|NP_001892.1|//connective tissue growth factor precursor [Homo sapiens]"]
[219654,4933,2.96,1.4,-1.08017034868398,2.96640874216867e-5,"Down",4.56286e-6,"ZCCHC24","NA","GO:0046914//transition metal ion binding","NA","NA","gi|194373563|dbj|BAG56877.1|//unnamed protein product [Homo sapiens];gi|54311313|gb|AAH39249.1|//ZCCHC24 protein, partial [Homo sapiens]"]
[100129543,2743,8.54,4.04,-1.0798807768687,5.4988999392352e-7,"Down",6.48468e-8,"ZNF730","GO:0005622//intracellular","GO:0046872//metal ion binding;GO:0005488//binding","GO:0006351//transcription, DNA-templated","K09228//KRAB domain-containing zinc finger protein","gi|119605340|gb|EAW84934.1|//hCG1645925 [Homo sapiens];gi|967497054|ref|XP_014978952.1|//PREDICTED: uncharacterized protein LOC106994689 [Macaca mulatta]"]
[55255,2298,13.04,6.17,-1.07960147508166,1.14692863476071e-10,"Down",8.4383e-12,"WDR41","NA","NA","NA","K12857//Prp8 binding protein;K10260//F-box and WD-40 domain protein 7;K11798//bromodomain and WD repeat domain containing protein 1/3","gi|530379396|ref|XP_005248608.1|//PREDICTED: WD repeat-containing protein 41 isoform X3 [Homo sapiens];gi|42716287|ref|NP_060738.2|//WD repeat-containing protein 41 [Homo sapiens];gi|795409176|ref|XP_011944639.1|//PREDICTED: WD repeat-containing protein 41 isoform X3 [Cercocebus atys];gi|767936168|ref|XP_011541807.1|//PREDICTED: WD repeat-containing protein 41 isoform X1 [Homo sapiens];gi|675645637|ref|XP_008990155.1|//PREDICTED: WD repeat-containing protein 41 isoform X1 [Callithrix jacchus]"]
[2957,6374,7.56,3.58,-1.07842664695682,1.21837673389222e-14,"Down",6.28456e-16,"GTF2A1","GO:0005667//transcription factor complex","GO:0008134//transcription factor binding;GO:0046983//protein dimerization activity;GO:0003676//nucleic acid binding","GO:0006354//DNA-templated transcription, elongation;GO:0006366//transcription from RNA polymerase II promoter;GO:0006352//DNA-templated transcription, initiation","K03122//transcription initiation factor TFIIA large subunit","gi|594050540|ref|XP_006049623.1|//PREDICTED: transcription initiation factor IIA subunit 1 isoform X1 [Bubalus bubalis];gi|655873309|ref|XP_008270184.1|//PREDICTED: transcription initiation factor IIA subunit 1 [Oryctolagus cuniculus]"]
[5226,2353,108.11,51.21,-1.07800251200127,4.63322697435897e-76,"Down",3.3487e-78,"PGD","GO:0044444//cytoplasmic part","GO:0016616//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0000166//nucleotide binding","GO:0006098//pentose-phosphate shunt;GO:0019321//pentose metabolic process","K00033//6-phosphogluconate dehydrogenase [EC:1.1.1.44 1.1.1.343]","gi|675767622|ref|XP_008973882.1|//PREDICTED: 6-phosphogluconate dehydrogenase, decarboxylating isoform X1 [Pan paniscus]"]
[59338,3881,6.98,3.31,-1.07639581940243,1.9257548195122e-8,"Down",1.853426e-9,"PLEKHA1","GO:0001726//ruffle;GO:0016020//membrane;GO:0031981//nuclear lumen","GO:0019904//protein domain specific binding;GO:0035091//phosphatidylinositol binding","GO:0022602//ovulation cycle process;GO:0034614//cellular response to reactive oxygen species;GO:0048232//male gamete generation;GO:0030030//cell projection organization;GO:0008202//steroid metabolic process;GO:0008406//gonad development;GO:0009887//animal organ morphogenesis;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0040007//growth;GO:0051234//establishment of localization;GO:0050851//antigen receptor-mediated signaling pathway","K12581//CCR4-NOT transcription complex subunit 7/8;K17776//metaxin;K11447//histone demethylase [EC:1.14.11.-];K01064//wingless-type MMTV integration site family, member 9","gi|795315996|ref|XP_011719724.1|//PREDICTED: pleckstrin homology domain-containing family A member 1 isoform X2 [Macaca nemestrina];gi|10198124|gb|AAG15197.1|AF286160_1//Tandem PH Domain Containing Protein-1 [Homo sapiens];gi|767963423|ref|XP_011538319.1|//PREDICTED: pleckstrin homology domain-containing family A member 1 isoform X3 [Homo sapiens]"]
[8717,1553,20.19,9.58,-1.07554334959529,5.95763540821069e-10,"Down",4.75124e-11,"TRADD","GO:0043232//intracellular non-membrane-bounded organelle;GO:0043234//protein complex;GO:0044444//cytoplasmic part","GO:0019904//protein domain specific binding;GO:0060089//molecular transducer activity;GO:0019899//enzyme binding","GO:0007249//I-kappaB kinase/NF-kappaB signaling;GO:0045684//positive regulation of epidermis development;GO:0019221//cytokine-mediated signaling pathway","K03171//tumor necrosis factor receptor type 1-associated DEATH domain protein","gi|808915|gb|AAA98482.1|//tumor necrosis factor receptor type 1 associated protein, partial [Homo sapiens]"]
[5338,3448,9.61,4.56,-1.07550260660901,2.12044761273517e-9,"Down",1.810266e-10,"PLD2","GO:0031252//cell leading edge;GO:0043231//intracellular membrane-bounded organelle;GO:0044459//plasma membrane part;GO:0005903//brush border","GO:0004620//phospholipase activity;GO:0005543//phospholipid binding;GO:0019901//protein kinase binding","GO:0016477//cell migration;GO:0033008//positive regulation of mast cell activation involved in immune response;GO:0035556//intracellular signal transduction;GO:0030030//cell projection organization;GO:0045807//positive regulation of endocytosis;GO:0006996//organelle organization;GO:0000302//response to reactive oxygen species;GO:0002029//desensitization of G-protein coupled receptor protein signaling pathway;GO:0009967//positive regulation of signal transduction;GO:0006644//phospholipid metabolic process;GO:0009725//response to hormone;GO:0030155//regulation of cell adhesion","K01115//phospholipase D1/2 [EC:3.1.4.4]","gi|156564407|ref|NP_002654.3|//phospholipase D2 isoform PLD2A [Homo sapiens];gi|2645858|gb|AAD04197.1|//phospholipase D2 [Homo sapiens];gi|340805823|ref|NP_001230037.1|//phospholipase D2 isoform PLD2B [Homo sapiens];gi|767992350|ref|XP_011522243.1|//PREDICTED: phospholipase D2 isoform X2 [Homo sapiens]"]
[79694,5009,4.13,1.96,-1.07528812730424,3.6807465e-6,"Down",4.87492e-7,"MANEA","GO:0031224//intrinsic component of membrane;GO:0043231//intracellular membrane-bounded organelle;GO:0012505//endomembrane system","GO:0004559//alpha-mannosidase activity","GO:0006487//protein N-linked glycosylation","K15538//glycoprotein endo-alpha-1,2-mannosidase [EC:3.2.1.130]","gi|31873298|emb|CAD97640.1|//hypothetical protein [Homo sapiens]"]
[201895,5544,8,3.8,-1.07400058144378,1.66268473846154e-13,"Down",9.48022e-15,"SMIM14","GO:0031224//intrinsic component of membrane","GO:0005488//binding","NA","K17985//activating molecule in BECN1-regulated autophagy protein 1","gi|767930212|ref|XP_011511942.1|//PREDICTED: small integral membrane protein 14 isoform X1 [Homo sapiens]"]
[1059,2856,36.92,17.56,-1.07210970811042,1.47346974301676e-31,"Down",3.2586e-33,"CENPB","GO:0043231//intracellular membrane-bounded organelle;GO:0044427//chromosomal part","GO:0043565//sequence-specific DNA binding","NA","K11496//centromere protein B","gi|21735415|ref|NP_001801.1|//major centromere autoantigen B [Homo sapiens]"]
[282969,855,38.88,18.52,-1.06994412034554,5.48883495597484e-7,"Down",6.46942e-8,"FUOM","NA","GO:0016854//racemase and epimerase activity","GO:0071702//organic substance transport","K02431//L-fucose mutarotase [EC:5.1.3.29]","gi|685565210|ref|XP_009213944.1|//PREDICTED: fucose mutarotase isoform X1 [Papio anubis];gi|767962559|ref|XP_011537974.1|//PREDICTED: fucose mutarotase isoform X3 [Homo sapiens];gi|966965431|ref|XP_015004004.1|//PREDICTED: fucose mutarotase isoform X1 [Macaca mulatta];gi|685424570|ref|NP_001288756.1|//fucose mutarotase isoform 3 [Homo sapiens];gi|767962555|ref|XP_011537972.1|//PREDICTED: fucose mutarotase isoform X1 [Homo sapiens];gi|119581741|gb|EAW61337.1|//chromosome 10 open reading frame 125, isoform CRA_a [Homo sapiens];gi|767962561|ref|XP_011537975.1|//PREDICTED: fucose mutarotase isoform X4 [Homo sapiens]"]
[203054,2037,8.32,3.97,-1.06744452099813,3.41586705910353e-5,"Down",5.31962e-6,"ADCK5","GO:0031224//intrinsic component of membrane","GO:0004672//protein kinase activity","NA","K08869//aarF domain-containing kinase","gi|525507394|ref|NP_777582.4|//uncharacterized aarF domain-containing protein kinase 5 [Homo sapiens];gi|767952664|ref|XP_011515209.1|//PREDICTED: uncharacterized aarF domain-containing protein kinase 5 isoform X1 [Homo sapiens]"]
[79641,1572,14.75,7.06,-1.06297486586539,2.36667663157895e-7,"Down",2.6389e-8,"ROGDI","GO:0044464//cell part","NA","GO:0008283//cell proliferation;GO:0048534//hematopoietic or lymphoid organ development","K16938//septin 3/9/12;K19367//maspardin","gi|13375779|ref|NP_078865.1|//protein rogdi homolog [Homo sapiens];gi|397488292|ref|XP_003815202.1|//PREDICTED: protein rogdi homolog [Pan paniscus];gi|694962298|ref|XP_009428511.1|//PREDICTED: protein rogdi homolog isoform X1 [Pan troglodytes]"]
[9793,6729,60.52,28.97,-1.06285230294633,3.3409431304918e-120,"Down",1.258942e-122,"CKAP5","GO:0005815//microtubule organizing center;GO:0043234//protein complex","GO:0005488//binding","GO:0050657//nucleic acid transport;GO:0031023//microtubule organizing center organization;GO:0007067//mitotic nuclear division","K16803//cytoskeleton-associated protein 5","gi|57222563|ref|NP_055571.2|//cytoskeleton-associated protein 5 isoform b [Homo sapiens];gi|57164942|ref|NP_001008938.1|//cytoskeleton-associated protein 5 isoform a [Homo sapiens]"]
[83660,12213,1.21,0.58,-1.06088224214702,6.67585562349398e-5,"Down",1.095322e-5,"TLN2","GO:0031252//cell leading edge;GO:0005856//cytoskeleton;GO:0005924//cell-substrate adherens junction","GO:0008092//cytoskeletal protein binding;GO:0005198//structural molecule activity;GO:0005102//receptor binding","GO:0034329//cell junction assembly;GO:0007010//cytoskeleton organization","K06271//talin","gi|767985518|ref|XP_011520410.1|//PREDICTED: talin-2 isoform X4 [Homo sapiens];gi|156938343|ref|NP_055874.2|//talin-2 [Homo sapiens];gi|530406530|ref|XP_005254764.1|//PREDICTED: talin-2 isoform X2 [Homo sapiens]"]
[26049,6025,4.65,2.23,-1.06018700607509,6.45611774847043e-9,"Down",5.86666e-10,"FAM169A","NA","NA","NA","K12869//crooked neck","gi|153792633|ref|NP_056381.1|//soluble lamin-associated protein of 75 kDa [Homo sapiens];gi|675708008|ref|XP_003810514.2|//PREDICTED: soluble lamin-associated protein of 75 kDa isoform X1 [Pan paniscus];gi|675708020|ref|XP_008961073.1|//PREDICTED: soluble lamin-associated protein of 75 kDa isoform X3 [Pan paniscus]"]
[100529215,2694,5.33,2.56,-1.05799172275918,4.53178502213592e-5,"Down",7.20864e-6,"ZNF559-ZNF177","GO:0043231//intracellular membrane-bounded organelle;GO:0005622//intracellular","GO:0046872//metal ion binding;GO:0046914//transition metal ion binding;GO:0003676//nucleic acid binding","GO:0006357//regulation of transcription from RNA polymerase II promoter","K09228//KRAB domain-containing zinc finger protein","gi|289547611|ref|NP_001166122.1|//zinc finger protein 177 isoform a [Homo sapiens];gi|289547607|ref|NP_003442.2|//zinc finger protein 177 isoform b [Homo sapiens]"]
[60489,1848,10.89,5.24,-1.05536523717946,1.75422798434442e-6,"Down",2.215e-7,"APOBEC3G","GO:0043231//intracellular membrane-bounded organelle;GO:0043234//protein complex;GO:0044444//cytoplasmic part","GO:0016814//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines;GO:0042802//identical protein binding;GO:0046914//transition metal ion binding;GO:0003676//nucleic acid binding","GO:0006216//cytidine catabolic process;GO:0045071//negative regulation of viral genome replication;GO:0050691//regulation of defense response to virus by host;GO:0009451//RNA modification","K18750//C->U-editing enzyme APOBEC3 [EC:3.5.4.-]","gi|13399304|ref|NP_068594.1|//DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens]"]
[23600,3306,8.29,3.99,-1.0549833552734,2.53740040677966e-8,"Down",2.49696e-9,"AMACR","GO:0044439//peroxisomal part","GO:0016854//racemase and epimerase activity","GO:0006694//steroid biosynthetic process;GO:0006635//fatty acid beta-oxidation","K01796//alpha-methylacyl-CoA racemase [EC:5.1.99.4]","gi|42794625|ref|NP_055139.4|//alpha-methylacyl-CoA racemase isoform 1 [Homo sapiens];gi|266456254|ref|NP_001161067.1|//alpha-methylacyl-CoA racemase isoform 3 [Homo sapiens];gi|148342485|gb|ABQ59031.1|//AMACR protein [Homo sapiens]"]
[1522,1517,115.78,55.79,-1.0533076051808,3.19908045658537e-50,"Down",4.05122e-52,"CTSZ","GO:0044421//extracellular region part;GO:0000323//lytic vacuole","GO:0004175//endopeptidase activity","GO:0019538//protein metabolic process","K08568//cathepsin X [EC:3.4.18.1]","gi|22538442|ref|NP_001327.2|//cathepsin Z preproprotein [Homo sapiens]"]
[27122,2598,10.23,4.93,-1.05314659336742,1.79058031495601e-9,"Down",1.508742e-10,"DKK3","GO:0044421//extracellular region part","NA","GO:0032342//aldosterone biosynthetic process;GO:0016055//Wnt signaling pathway;GO:0031947//negative regulation of glucocorticoid biosynthetic process;GO:0035270//endocrine system development","K02165//dickkopf","gi|194380590|dbj|BAG58448.1|//unnamed protein product [Homo sapiens];gi|6049608|gb|AAF02676.1|AF177396_1//dickkopf-3 [Homo sapiens];gi|397494714|ref|XP_003818218.1|//PREDICTED: dickkopf-related protein 3 isoform X1 [Pan paniscus]"]
[3077,2732,17.13,8.26,-1.05231146466455,2.66362616110521e-13,"Down",1.548352e-14,"HFE","GO:0005768//endosome;GO:0016021//integral component of membrane;GO:0005886//plasma membrane;GO:0031982//vesicle;GO:0042611//MHC protein complex","GO:0005488//binding","GO:0000041//transition metal ion transport;GO:0009267//cellular response to starvation;GO:0022414//reproductive process;GO:0065003//macromolecular complex assembly;GO:0048002//antigen processing and presentation of peptide antigen;GO:0002376//immune system process;GO:0009058//biosynthetic process;GO:0006875//cellular metal ion homeostasis;GO:0006897//endocytosis;GO:0048871//multicellular organismal homeostasis","K06751//major histocompatibility complex, class I","gi|21040349|ref|NP_620576.1|//hereditary hemochromatosis protein isoform 7 precursor [Homo sapiens];gi|4504377|ref|NP_000401.1|//hereditary hemochromatosis protein isoform 1 precursor [Homo sapiens];gi|21040347|ref|NP_620575.1|//hereditary hemochromatosis protein isoform 6 precursor [Homo sapiens];gi|346720360|gb|AEO50368.1|//hereditary hemochromatosis protein [Homo sapiens];gi|21040351|ref|NP_620577.1|//hereditary hemochromatosis protein isoform 8 precursor [Homo sapiens];gi|767939870|ref|XP_011512845.1|//PREDICTED: hereditary hemochromatosis protein isoform X1 [Homo sapiens];gi|426351821|ref|XP_004043424.1|//PREDICTED: hereditary hemochromatosis protein isoform 9 [Gorilla gorilla gorilla];gi|426351817|ref|XP_004043422.1|//PREDICTED: hereditary hemochromatosis protein isoform 7 [Gorilla gorilla gorilla];gi|21040353|ref|NP_620578.1|//hereditary hemochromatosis protein isoform 9 precursor [Homo sapiens];gi|21040343|ref|NP_620573.1|//hereditary hemochromatosis protein isoform 4 precursor [Homo sapiens];gi|663429517|ref|NP_001287678.1|//hereditary hemochromatosis protein isoform 12 precursor [Homo sapiens]"]
[56940,2468,7.85,3.79,-1.0504948056079,0.000569066122215308,"Down",0.0001129836,"DUSP22","GO:0043231//intracellular membrane-bounded organelle","GO:0004721//phosphoprotein phosphatase activity;GO:0005488//binding","GO:0006464//cellular protein modification process;GO:0008283//cell proliferation;GO:0012501//programmed cell death;GO:0006470//protein dephosphorylation;GO:0043410//positive regulation of MAPK cascade;GO:0007178//transmembrane receptor protein serine/threonine kinase signaling pathway;GO:0032501//multicellular organismal process","K14165//atypical dual specificity phosphatase [EC:3.1.3.16 3.1.3.48];K17582//antigen KI-67","gi|426351388|ref|XP_004043230.1|//PREDICTED: LOW QUALITY PROTEIN: dual specificity protein phosphatase 22 [Gorilla gorilla gorilla];gi|767940386|ref|XP_011513059.1|//PREDICTED: dual specificity protein phosphatase 22 isoform X1 [Homo sapiens];gi|9910432|ref|NP_064570.1|//dual specificity protein phosphatase 22 isoform b [Homo sapiens];gi|999984251|gb|KXJ23392.1|//hypothetical protein AC249_AIPGENE5217 [Exaiptasia pallida];gi|557440816|ref|NP_001273484.1|//dual specificity protein phosphatase 22 isoform a [Homo sapiens] "]
[113026,3486,10.25,4.95,-1.05012347942584,7.32172410977701e-11,"Down",5.27374e-12,"PLCD3","GO:0044424//intracellular part;GO:0032155//cell division site part","GO:0046872//metal ion binding;GO:0060089//molecular transducer activity;GO:0004629//phospholipase C activity","GO:0007165//signal transduction;GO:0008283//cell proliferation;GO:0048646//anatomical structure formation involved in morphogenesis;GO:0048568//embryonic organ development;GO:0006629//lipid metabolic process","K05857//phosphatidylinositol phospholipase C, delta [EC:3.1.4.11]","gi|767993376|ref|XP_011522555.1|//PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [Homo sapiens];gi|19115964|ref|NP_588614.1|//1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [Homo sapiens]"]
[3219,2711,7.18,3.47,-1.04904818124479,2.97490804532578e-6,"Down",3.8923e-7,"HOXB9","GO:0031981//nuclear lumen","GO:0003677//DNA binding;GO:0001071//nucleic acid binding transcription factor activity","GO:0006357//regulation of transcription from RNA polymerase II promoter;GO:0048732//gland development;GO:0016055//Wnt signaling pathway;GO:0003002//regionalization;GO:0006935//chemotaxis;GO:0001501//skeletal system development","K09294//homeobox protein HoxA/B/C/D9","gi|15029508|ref|NP_076922.1|//homeobox protein Hox-B9 [Homo sapiens]"]
[89848,2398,6.37,3.08,-1.0483630215614,0.000284977016989967,"Down",5.26366e-5,"FCHSD1","NA","NA","NA","K20125//F-BAR and double SH3 domains protein","gi|767937897|ref|XP_011536003.1|//PREDICTED: FCH and double SH3 domains protein 1 isoform X5 [Homo sapiens];gi|28875786|ref|NP_258260.1|//F-BAR and double SH3 domains protein 1 [Homo sapiens];gi|578810932|ref|XP_006714866.1|//PREDICTED: FCH and double SH3 domains protein 1 isoform X2 [Homo sapiens];gi|767937888|ref|XP_011536000.1|//PREDICTED: FCH and double SH3 domains protein 1 isoform X3 [Homo sapiens];gi|530380710|ref|XP_005268581.1|//PREDICTED: FCH and double SH3 domains protein 1 isoform X1 [Homo sapiens]"]
[219743,3798,13.07,6.32,-1.04826267761833,1.20156109352518e-14,"Down",6.1904e-16,"TYSND1","GO:0042579//microbody","GO:0004175//endopeptidase activity","GO:0019538//protein metabolic process","K15696//RING finger protein 113B;K17985//activating molecule in BECN1-regulated autophagy protein 1;K04460//serine/threonine-protein phosphatase 5 [EC:3.1.3.16]","gi|795191318|ref|XP_011846567.1|//PREDICTED: peroxisomal leader peptide-processing protease [Mandrillus leucophaeus];gi|94400921|ref|NP_775826.2|//peroxisomal leader peptide-processing protease isoform a [Homo sapiens];gi|795520118|ref|XP_011713279.1|//PREDICTED: peroxisomal leader peptide-processing protease isoform X1 [Macaca nemestrina];gi|94400923|ref|NP_001035363.1|//peroxisomal leader peptide-processing protease isoform b [Homo sapiens];gi|112180747|gb|AAI11502.2|//Trypsin domain containing 1 [Homo sapiens]"]
[201255,2741,14.16,6.86,-1.04554078391019,1.50661180367647e-11,"Down",1.012598e-12,"LRRC45","NA","NA","NA","K07861//Ras-related C3 botulinum toxin substrate 3;K12175//COP9 signalosome complex subunit 1;K10165//nucleotide-binding oligomerization domain-containing protein 2","gi|21450705|ref|NP_659436.1|//leucine-rich repeat-containing protein 45 [Homo sapiens]"]
[9213,8500,5.44,2.64,-1.04306872189189,9.62821275915649e-14,"Down",5.35892e-15,"XPR1","GO:0016021//integral component of membrane","GO:0004888//transmembrane signaling receptor activity","GO:0051707//response to other organism;GO:0007166//cell surface receptor signaling pathway","K12581//CCR4-NOT transcription complex subunit 7/8;K06245//laminin, beta 4;K02927//large subunit ribosomal protein L40e;K12025//tripartite motif-containing protein 52","gi|208609982|ref|NP_001129141.1|//xenotropic and polytropic retrovirus receptor 1 isoform 2 [Homo sapiens];gi|19923272|ref|NP_004727.2|//xenotropic and polytropic retrovirus receptor 1 isoform 1 [Homo sapiens]"]
[84987,760,62.06,30.18,-1.04007089100204,8.98972508796764e-13,"Down",5.49224e-14,"COX14","GO:0031224//intrinsic component of membrane;GO:0043231//intracellular membrane-bounded organelle","NA","NA","K18181//cytochrome c oxidase assembly factor 14","gi|355564221|gb|EHH20721.1|//hypothetical protein EGK_03635 [Macaca mulatta]"]
[84875,3504,4.23,2.06,-1.03801332593673,5.60496862757045e-5,"Down",9.09232e-6,"PARP10","GO:0031981//nuclear lumen","GO:0016763//transferase activity, transferring pentosyl groups;GO:0005488//binding","NA","K15261//poly [ADP-ribose] polymerase 10/14/15 [EC:2.4.2.30]","gi|767953713|ref|XP_011515638.1|//PREDICTED: poly [ADP-ribose] polymerase 10 isoform X2 [Homo sapiens];gi|961525471|ref|NP_001304824.1|//poly [ADP-ribose] polymerase 10 isoform 2 [Homo sapiens]"]
[374969,812,22.61,11.02,-1.03683676818037,9.49706881893906e-6,"Down",1.338202e-6,"SVBP","NA","NA","NA","NA","gi|984098893|ref|XP_015340645.1|//PREDICTED: small vasohibin-binding protein isoform X1 [Marmota marmota marmota]"]
[5337,5393,3.69,1.8,-1.03562390973072,1.34069637287846e-5,"Down",1.942138e-6,"PLD1","GO:0012505//endomembrane system;GO:0031252//cell leading edge;GO:0005795//Golgi stack;GO:0005770//late endosome;GO:0031090//organelle membrane","GO:0004620//phospholipase activity;GO:0005543//phospholipid binding","GO:0016477//cell migration;GO:0046394//carboxylic acid biosynthetic process;GO:0007264//small GTPase mediated signal transduction;GO:0006644//phospholipid metabolic process;GO:0009725//response to hormone;GO:0042742//defense response to bacterium","K01115//phospholipase D1/2 [EC:3.1.4.4]","gi|767926921|ref|XP_011511199.1|//PREDICTED: phospholipase D1 isoform X3 [Homo sapiens];gi|4505873|ref|NP_002653.1|//phospholipase D1 isoform a [Homo sapiens];gi|62089400|dbj|BAD93144.1|//phospholipase D1 variant [Homo sapiens]"]
[11187,2879,28.74,14.02,-1.03557371244671,1.667364e-23,"Down",5.0882e-25,"PKP3","GO:0043231//intracellular membrane-bounded organelle;GO:0005913//cell-cell adherens junction","NA","GO:0009987//cellular process","K12642//plakophilin 2;K18468//vacuolar protein sorting-associated protein 35","gi|732663005|ref|NP_001289958.1|//plakophilin-3 isoform PKP3b [Homo sapiens];gi|6005830|ref|NP_009114.1|//plakophilin-3 isoform PKP3a [Homo sapiens]"]
[5573,3078,159.9,78.07,-1.03432976403156,1.192149072e-172,"Down",2.57754e-175,"PRKAR1A","GO:0043234//protein complex;GO:0045202//synapse;GO:0044444//cytoplasmic part","GO:0019887//protein kinase regulator activity;GO:0016208//AMP binding","GO:0006355//regulation of transcription, DNA-templated;GO:0032147//activation of protein kinase activity;GO:0001704//formation of primary germ layer;GO:0030073//insulin secretion;GO:0010863//positive regulation of phospholipase C activity;GO:0015980//energy derivation by oxidation of organic compounds;GO:0007169//transmembrane receptor protein tyrosine kinase signaling pathway;GO:0033762//response to glucagon;GO:0007599//hemostasis;GO:0042044//fluid transport","K04739//cAMP-dependent protein kinase regulator","gi|4506063|ref|NP_002725.1|//cAMP-dependent protein kinase type I-alpha regulatory subunit isoform a [Homo sapiens];gi|443497966|ref|NP_001263219.1|//cAMP-dependent protein kinase type I-alpha regulatory subunit isoform b [Homo sapiens]"]
[51200,2817,52.84,25.81,-1.03370032515286,4.32126129539749e-42,"Down",6.37992e-44,"CPA4","NA","GO:0046914//transition metal ion binding;GO:0008235//metalloexopeptidase activity","GO:0016570//histone modification","K08637//carboxypeptidase A4 [EC:3.4.17.-]","gi|254540196|ref|NP_001156918.1|//carboxypeptidase A4 isoform 2 preproprotein [Homo sapiens] ;gi|61743916|ref|NP_057436.2|//carboxypeptidase A4 preproprotein [Homo sapiens]"]
[8353,462,255.17,124.86,-1.03114735241454,5.10113394033149e-31,"Down",1.140728e-32,"HIST1H3E","NA","NA","NA","K11253//histone H3","gi|958733252|ref|XP_014707113.1|//PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC106837883 [Equus asinus]"]
[114882,7205,18.82,9.23,-1.02786407508276,6.5432808e-38,"Down",1.147944e-39,"OSBPL8","NA","GO:0005488//binding","GO:0010876//lipid localization;GO:0051234//establishment of localization","K20464//oxysterol-binding protein-related protein 5/8","gi|635066946|ref|XP_008002266.1|//PREDICTED: oxysterol-binding protein-related protein 8 isoform X2 [Chlorocebus sabaeus];gi|985567522|ref|NP_001306584.1|//oxysterol-binding protein-related protein 8 isoform d [Homo sapiens];gi|635066948|ref|XP_008002267.1|//PREDICTED: oxysterol-binding protein-related protein 8 isoform X3 [Chlorocebus sabaeus];gi|767973054|ref|XP_011536160.1|//PREDICTED: oxysterol-binding protein-related protein 8 isoform X6 [Homo sapiens];gi|635066950|ref|XP_008002268.1|//PREDICTED: oxysterol-binding protein-related protein 8 isoform X4 [Chlorocebus sabaeus];gi|635066944|ref|XP_008002265.1|//PREDICTED: oxysterol-binding protein-related protein 8 isoform X1 [Chlorocebus sabaeus]"]
[107986352,3507,5.34,2.62,-1.0272729301501,8.22512351660026e-6,"Down",1.147798e-6,"LOC107986352","NA","NA","NA","K14316//nuclear pore complex protein Nup121","gi|768043242|ref|XP_006726288.2|//PREDICTED: putative POM121-like protein 1-like [Homo sapiens]"]
[79633,17192,2.67,1.31,-1.0272729301501,2.57054406645367e-13,"Down",1.491068e-14,"FAT4","GO:0031224//intrinsic component of membrane","GO:0046872//metal ion binding","GO:0016337//single organismal cell-cell adhesion","K16669//protocadherin Fat 4","gi|603844373|ref|NP_001278214.1|//protocadherin Fat 4 isoform 2 precursor [Homo sapiens];gi|604723349|ref|NP_001278232.1|//protocadherin Fat 4 isoform 1 precursor [Homo sapiens] ;gi|165932370|ref|NP_078858.4|//protocadherin Fat 4 isoform 3 precursor [Homo sapiens]"]
[83444,1266,19.3,9.47,-1.02716451668706,3.03154373058121e-7,"Down",3.44766e-8,"INO80B","NA","NA","NA","K11666//INO80 complex subunit B","gi|795184348|ref|XP_011801455.1|//PREDICTED: INO80 complex subunit B isoform X1 [Colobus angolensis palliatus]"]
[399687,7564,18.8,9.23,-1.02633010891923,3.77155590804598e-40,"Down",6.0809e-42,"MYO18A","GO:0015629//actin cytoskeleton;GO:0044444//cytoplasmic part","GO:0005515//protein binding;GO:0032559//adenyl ribonucleotide binding;GO:0042623//ATPase activity, coupled;GO:0003676//nucleic acid binding","GO:0044260//cellular macromolecule metabolic process;GO:0043066//negative regulation of apoptotic process","K10362//myosin XVIII","gi|42794779|ref|NP_976063.1|//unconventional myosin-XVIIIa isoform b [Homo sapiens];gi|28416946|ref|NP_510880.2|//unconventional myosin-XVIIIa isoform a [Homo sapiens]"]
[120,4409,22.31,10.98,-1.02281245923894,2.62069480555556e-27,"Down",6.9937e-29,"ADD3","GO:0000228//nuclear chromosome;GO:0030054//cell junction;GO:0044444//cytoplasmic part","GO:0043169//cation binding;GO:0008092//cytoskeletal protein binding;GO:0005198//structural molecule activity;GO:0019901//protein kinase binding","GO:0042221//response to chemical","K18622//adducin","gi|62089206|dbj|BAD93047.1|//adducin 3 isoform a variant [Homo sapiens];gi|9951927|ref|NP_063968.1|//gamma-adducin isoform b [Homo sapiens]"]
[5357,3720,7.27,3.58,-1.02199577665534,3.86071838423645e-8,"Down",3.87312e-9,"PLS1","GO:0044424//intracellular part","GO:0003779//actin binding;GO:0046872//metal ion binding;GO:0005198//structural molecule activity","NA","K17275//plastin-1","gi|223718246|ref|NP_002661.2|//plastin-1 [Homo sapiens]"]
[8294,370,497.8,245.19,-1.02166608997135,2.53034105806452e-46,"Down",3.39192e-48,"HIST1H4I","GO:0043231//intracellular membrane-bounded organelle;GO:0000785//chromatin","NA","GO:0034728//nucleosome organization","K11253//histone H3;K11254//histone H4","gi|625285956|ref|XP_007634698.1|//PREDICTED: LOW QUALITY PROTEIN: histone H4 isoform X2 [Cricetulus griseus]"]
[2995,1249,10.27,5.06,-1.02122689162389,0.000584371220117976,"Down",0.000116275,"GYPC","GO:0005856//cytoskeleton;GO:0016021//integral component of membrane","GO:0005488//binding","NA","K06576//glycophorin C","gi|578804160|ref|XP_006712523.1|//PREDICTED: glycophorin-C isoform X1 [Homo sapiens];gi|8051605|ref|NP_058131.1|//glycophorin-C isoform 2 [Homo sapiens] ;gi|183327|gb|AAA52574.1|//glycophorin C [Homo sapiens];gi|4504229|ref|NP_002092.1|//glycophorin-C isoform 1 [Homo sapiens]"]
[3897,5075,5.82,2.87,-1.0199684162326,8.5111133164557e-9,"Down",7.89176e-10,"L1CAM","GO:0031224//intrinsic component of membrane;GO:0009986//cell surface;GO:0033267//axon part","GO:0019904//protein domain specific binding;GO:0048029//monosaccharide binding;GO:0005102//receptor binding","GO:0016337//single organismal cell-cell adhesion;GO:0030030//cell projection organization;GO:0048731//system development;GO:0048869//cellular developmental process;GO:0002376//immune system process;GO:0009967//positive regulation of signal transduction;GO:0006935//chemotaxis;GO:0007599//hemostasis","K06550//L1 cell adhesion molecule","gi|4557707|ref|NP_000416.1|//neural cell adhesion molecule L1 isoform 1 precursor [Homo sapiens];gi|13435353|ref|NP_076493.1|//neural cell adhesion molecule L1 isoform 2 precursor [Homo sapiens];gi|221316760|ref|NP_001137435.1|//neural cell adhesion molecule L1 isoform 3 precursor [Homo sapiens]"]
[10687,4846,6.63,3.27,-1.01971823461451,1.90718762366691e-9,"Down",1.612886e-10,"PNMA2","GO:0031981//nuclear lumen","GO:0005488//binding","GO:0012501//programmed cell death","K17985//activating molecule in BECN1-regulated autophagy protein 1;K01064//wingless-type MMTV integration site family, member 9","gi|11464969|ref|NP_009188.1|//paraneoplastic antigen Ma2 [Homo sapiens]"]
[4131,12019,6.16,3.04,-1.01885902725132,1.39818712069565e-20,"Down",4.96638e-22,"MAP1B","GO:0016020//membrane;GO:0015630//microtubule cytoskeleton;GO:0030427//site of polarized growth;GO:0044430//cytoskeletal part;GO:0044444//cytoplasmic part;GO:0043025//neuronal cell body;GO:0043005//neuron projection","GO:0015631//tubulin binding;GO:0008289//lipid binding","GO:0031103//axon regeneration;GO:0007019//microtubule depolymerization;GO:0030307//positive regulation of cell growth;GO:0043627//response to estrogen;GO:0009636//response to toxic substance;GO:0031112//positive regulation of microtubule polymerization or depolymerization;GO:0051914//positive regulation of synaptic plasticity by chemical substance;GO:0045597//positive regulation of cell differentiation;GO:0033273//response to vitamin","K10429//microtubule-associated protein 1","gi|153945728|ref|NP_005900.2|//microtubule-associated protein 1B [Homo sapiens]"]
[284071,4572,5.19,2.57,-1.013966179164,8.89454039947206e-6,"Down",1.248906e-6,"MEIOC","NA","NA","NA","NA","gi|274315853|ref|NP_001138552.2|//meiosis-specific coiled-coil domain-containing protein MEIOC [Homo sapiens];gi|530411953|ref|XP_005257293.1|//PREDICTED: uncharacterized protein C17orf104 isoform X1 [Homo sapiens]"]
[8654,5206,2.4,1.19,-1.01207283230057,3.10531054981993e-5,"Down",4.79378e-6,"PDE5A","GO:0044444//cytoplasmic part","GO:0004114//3',5'-cyclic-nucleotide phosphodiesterase activity;GO:0046914//transition metal ion binding;GO:0019002//GMP binding","GO:0001775//cell activation;GO:0023052//signaling;GO:0007599//hemostasis;GO:0009123//nucleoside monophosphate metabolic process","K13762//cGMP-specific 3',5'-cyclic phosphodiesterase [EC:3.1.4.35]","gi|61744435|ref|NP_001074.2|//cGMP-specific 3',5'-cyclic phosphodiesterase isoform 1 [Homo sapiens];gi|61744430|ref|NP_236914.2|//cGMP-specific 3',5'-cyclic phosphodiesterase isoform 2 [Homo sapiens];gi|119625682|gb|EAX05277.1|//phosphodiesterase 5A, cGMP-specific, isoform CRA_c [Homo sapiens]"]
[10735,5552,28.71,14.24,-1.01160418424078,3.76678631734317e-39,"Down",6.3059e-41,"STAG2","GO:0031981//nuclear lumen;GO:0044427//chromosomal part","GO:0005488//binding","GO:0007059//chromosome segregation;GO:0010948//negative regulation of cell cycle process;GO:0007067//mitotic nuclear division","K06671//cohesin complex subunit SA-1/2","gi|532067087|ref|XP_005319393.1|//PREDICTED: cohesin subunit SA-2 isoform X1 [Ictidomys tridecemlineatus];gi|31563531|ref|NP_006594.3|//cohesin subunit SA-2 isoform b [Homo sapiens]"]
[6876,1182,190.64,94.83,-1.00743541556462,2.6423839862069e-59,"Down",2.84022e-61,"TAGLN","GO:0044424//intracellular part","GO:0008092//cytoskeletal protein binding","GO:0048513//animal organ development","K20526//transgelin","gi|119587704|gb|EAW67300.1|//transgelin, isoform CRA_c [Homo sapiens]"]
[23321,4021,3.9,1.94,-1.00741747156248,2.31079748137432e-11,"Down",1.578788e-12,"TRIM2","GO:0044424//intracellular part;GO:0044464//cell part","GO:0046914//transition metal ion binding","NA","K11997//tripartite motif-containing protein 2/3","gi|705044243|ref|NP_001289621.1|//tripartite motif-containing protein 2 isoform 3 [Homo sapiens];gi|578808960|ref|XP_006714220.1|//PREDICTED: tripartite motif-containing protein 2 isoform X1 [Homo sapiens];gi|578808962|ref|XP_006714221.1|//PREDICTED: tripartite motif-containing protein 2 isoform X2 [Homo sapiens];gi|795540959|ref|XP_011904389.1|//PREDICTED: tripartite motif-containing protein 2 isoform X2 [Cercocebus atys];gi|705044290|ref|NP_001289622.1|//tripartite motif-containing protein 2 isoform 4 [Homo sapiens];gi|705044345|ref|NP_001289623.1|//tripartite motif-containing protein 2 isoform 5 [Homo sapiens];gi|194248079|ref|NP_056086.2|//tripartite motif-containing protein 2 isoform 1 [Homo sapiens];gi|767931522|ref|XP_011530096.1|//PREDICTED: tripartite motif-containing protein 2 isoform X4 [Homo sapiens];gi|119625368|gb|EAX04963.1|//tripartite motif-containing 2, isoform CRA_c [Homo sapiens];gi|578808964|ref|XP_006714222.1|//PREDICTED: tripartite motif-containing protein 2 isoform X3 [Homo sapiens];gi|686717283|ref|XP_009238657.1|//PREDICTED: LOW QUALITY PROTEIN: tripartite motif-containing protein 2 [Pongo abelii]"]
[7008,4403,4.65,2.32,-1.00310591086782,3.88649224778761e-6,"Down",5.15462e-7,"TEF","NA","GO:0003677//DNA binding","GO:0006355//regulation of transcription, DNA-templated","K09058//thyrotrophic embryonic factor","gi|4507431|ref|NP_003207.1|//thyrotroph embryonic factor isoform 1 [Homo sapiens];gi|512966800|ref|XP_004845582.1|//PREDICTED: thyrotroph embryonic factor isoform X2 [Heterocephalus glaber]"]
[28978,1015,32.89,16.44,-1.00043870915372,3.43829954748603e-9,"Down",3.04154e-10,"TMEM14A","GO:0031224//intrinsic component of membrane","NA","NA","NA","gi|635094468|ref|XP_007970445.1|//PREDICTED: transmembrane protein 14A isoform X1 [Chlorocebus sabaeus]"]