The PDF file includes:

• Fig. S1. ME and control region sizes, and Guo et al. methylome coverage.
• Fig. S2. Mean methylation at MEs and clustered control regions assayed by Guo et al.
• Fig. S3. Mean methylation at all CpGs and at MEs and clustered control regions assayed by Zhu et al. (21).
• Fig. S4. Methylation dynamics at the ICM–to–embryonic liver transition.
• Fig. S5. ME background comparisons in other fetal tissues, and methylation in control clusters.

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Other Supplementary Material for this manuscript includes the following:

• Table S1 (Microsoft Excel format). MEs identified in genome-wide screen.
• Table S2 (Microsoft Excel format). Enrichment of proximal genomic features in MEs.
• Table S3 (Microsoft Excel format). Number of CpGs covered in each replicate of RRBS data from Guo et al.
• Table S4 (Microsoft Excel format). Size of ME and control regions, and their coverage in Guo et al. RRBS data.
• Table S5 (Microsoft Excel format). Overlap of Bak et al. (28) ZFP57-mutant DMRs with MEs.

Download Tables S1 to S5