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{"sheet":"Trp53WT","index":0,"n_rows":73,"n_cols":6,"rows_kept":73,"cut":false,"hidden":false,"merged":[]}
["Inflammatory Response Functional Category"]
["Diseases or Functions Annotation","p-Value","Predicted Activation State","Activation z-score","Molecules","# Molecules"]
["Immune response of leukocytes",3.2499999999999998E-11,"Increased",2.915,"ABCA1,AXL,BAX,BTK,C3AR1,CCL22,CD274,CD38,CD68,CD80,CD86,CSF2RB,CTSS,CXCL10,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,GAB2,HSP90AA1,ICAM1,INPP5D,KLRB1,LCP2,LILRB4,MSR1,PLAU,PLXNA1,Pmaip1,RASA4,RELB,Rfx5,SAA1,SCARF1,SIGLEC1,SPI1,TAP1,TGFBR2,TLR7,TLR9,TNFRSF1A,TNFRSF1B,TPH1,TREM2,TREML2,TYROBP,UCP2,VAV1",49]
["Immune response of cells",1.7900000000000001E-8,"Increased",2.8319999999999999,"ABCA1,Abcb1b,AXL,BAX,BTK,C1QA,C3AR1,CCL22,CD274,CD38,CD68,CD80,CD86,CSF2RB,CSF3R,CTSS,CXCL10,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,FCGR3A/FCGR3B,GAB2,GAS6,HSP90AA1,ICAM1,INPP5D,KLRB1,LCP2,LILRB4,MSR1,PLAU,PLXNA1,Pmaip1,PROS1,RAC2,RASA4,RELB,Rfx5,SAA1,SCARF1,SIGLEC1,SPI1,TAP1,TGFBR2,TLR7,TLR9,TNFRSF10A,TNFRSF1A,TNFRSF1B,TNFSF12,TPH1,TREM2,TREML2,TYROBP,UCP2,VAV1",58]
["Phagocytosis of blood cells",6.6300000000000005E-8,"Increased",3.2869999999999999,"ABCA1,AXL,BTK,C3AR1,CD38,CSF2RB,CXCL10,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,GAB2,ICAM1,INPP5D,MSR1,PLAU,RAC2,RASA4,RELB,SAA1,SCARF1,SIGLEC1,SPI1,TPH1,TREM2,TREML2,UCP2",28]
["Phagocytosis of leukocytes",6.6600000000000001E-8,"Increased",3.1549999999999998,"ABCA1,AXL,BTK,C3AR1,CD38,CSF2RB,CXCL10,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,GAB2,ICAM1,INPP5D,MSR1,PLAU,RASA4,RELB,SAA1,SCARF1,SIGLEC1,SPI1,TPH1,TREM2,TREML2,UCP2",27]
["Phagocytosis",1.3E-7,"Increased",4.0869999999999997,"ABCA1,AXL,BTK,C1QA,C3AR1,CD38,CSF2RB,CSF3R,CXCL10,DEF6,EPG5,FAS,FCER1G,FCGR1A,FCGR2A,FCGR3A/FCGR3B,GAB2,GAS6,ICAM1,INPP5D,MSR1,PLAU,PROS1,RAC2,RASA4,RELB,RXRA,SAA1,SCARF1,SIGLEC1,SPI1,TLR9,TPH1,TREM2,TREML2,UCP2,VAV1",37]
["Phagocytosis of cells",1.6899999999999999E-7,"Increased",3.8969999999999998,"ABCA1,AXL,BTK,C1QA,C3AR1,CD38,CSF2RB,CSF3R,CXCL10,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,FCGR3A/FCGR3B,GAB2,GAS6,ICAM1,INPP5D,MSR1,PLAU,PROS1,RAC2,RASA4,RELB,SAA1,SCARF1,SIGLEC1,SPI1,TLR9,TPH1,TREM2,TREML2,UCP2,VAV1",35]
["Phagocytosis of phagocytes",3.9900000000000001E-7,"Increased",2.883,"ABCA1,AXL,BTK,C3AR1,CD38,CSF2RB,CXCL10,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,GAB2,ICAM1,INPP5D,PLAU,RASA4,RELB,SAA1,SCARF1,SIGLEC1,SPI1,TPH1,TREM2,UCP2",25]
["Engulfment by macrophages",4.6699999999999999E-7,"Increased",2.6139999999999999,"ABCA1,AXL,BTK,C3AR1,CD38,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,GAB2,INPP5D,PROS1,RASA4,SAA1,SCARF1,SIGLEC1,SPI1,TLR9,TPH1,TREM2,TREML2,UCP2",23]
["Function of immune system",4.7999999999999996E-7," "," ","C3AR1,CD22,CD274,CD300A,CSF2RB,FCER1G,FCGR1A,FCGR2A,FUT7,FYN,GAB2,ICAM1,IL21R,IRF1,LILRB4,LTBR,NFATC1,NOD1,PAK1,RELB,SEMA4B,TCIRG1,TLR9,TNFRSF1A,TNFRSF1B,TNFSF11,VAV1",27]
["Immune response of antigen presenting cells",6.6899999999999997E-7,"Increased",2.964,"ABCA1,AXL,BTK,C3AR1,CCL22,CD38,CD68,CD86,CTSS,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,GAB2,HSP90AA1,INPP5D,LILRB4,RASA4,SAA1,SCARF1,SIGLEC1,SPI1,TAP1,TLR7,TLR9,TPH1,TREM2,UCP2",29]
["Immune response of phagocytes",8.4799999999999997E-7,"Increased",3.2850000000000001,"ABCA1,AXL,BTK,C3AR1,CCL22,CD38,CSF2RB,CXCL10,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,GAB2,ICAM1,INPP5D,PLAU,RASA4,RELB,SAA1,SCARF1,SIGLEC1,SPI1,TLR7,TLR9,TPH1,TREM2,TYROBP,UCP2",29]
["Quantity of phagocytes",1.42E-6," ",0.39200000000000002,"ABCA1,ACAT1,BCL2A1,C1QA,C3AR1,C6,CCL2,CCL22,CCL3L3,CD300A,CD86,CDKN1A,CLU,CSF1,CSF3R,CTSB,CTSS,CX3CL1,CXCL10,Cxcl15,EZH2,FAS,FCER1G,FCGR2A,FUT7,GAB2,GDF15,ICAM1,IL6ST,INPP5D,IRF1,LGALS9B,LIF,LILRB4,LIPG,LTBR,LTC4S,Ly6a (includes others),MFAP2,NFE2L2,NFKB2,NPC1,PILRA,PLA2G2D,PLAU,PTRH2,RAC2,RELB,RPS6KA3,SHCBP1,SLC25A21,SPI1,Srgn,TGFBR2,TNFRSF1A,TNFSF11,TPH1,TREM2,TYROBP,USP2",60]
["Activation of leukocytes",2.12E-6," ",0.72199999999999998,"ABHD12,AXL,BAX,BTK,C3AR1,CCL2,CCL22,CD22,CD274,CD38,CD48,CD80,CD84,CD86,CDKN1A,CHRNA4,CLCN7,CSF1,CSF2RB,CXCL10,DEF6,DUSP22,FAS,FCER1G,FCGR1A,FCGR2A,FCGR3A/FCGR3B,FYN,HSPD1,ICAM1,IL21R,INPP5D,IRF1,IRF5,KLRB1,LAPTM5,LCP2,LGALS9B,Milr1,NFE2L2,NFKB2,NOTCH1,NPC1,NR1H3,PILRB,PLA2G2D,RELB,SAA1,TGFBR2,TLR7,TLR9,TNFAIP8L2,TNFRSF1B,TPT1,TREM2,TREML2,TRPM2,TXLNA,TYROBP,UNC93B1,VAV1",61]
["Accumulation of leukocytes",2.5500000000000001E-6,"Increased",2.222,"ACKR2,ARRB2,BCL2A1,CCL2,CCL22,CCL3L3,CD274,CD80,CD86,CSF1,CX3CL1,CXCL10,DEF6,EZH2,FAS,FCGR2A,FCGR3A/FCGR3B,GRN,ICAM1,IL21R,IL6ST,INPP5D,IRF1,IRF5,LTC4S,NOTCH1,NPC1,P2RY2,PAFAH1B1,PLAU,PPARD,SOS2,TGFBR2,TLR9,TNFAIP8L2,TNFRSF1B,TYROBP",37]
["Inflammation of joint",4.9300000000000002E-6," ",0.21199999999999999,"AREG,AXL,C3AR1,CAMK2D,CCL2,CCL3L3,Ccl8,CD274,CDKN1A,CSF2RB,CSF3R,CTSS,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,FCGR3A/FCGR3B,GRN,IL18BP,IL21R,IL6ST,IRF1,LGALS9B,LTBR,MMP2,Ms4a6c,MS4A7,MSR1,NFATC1,PILRA,PLAU,SAA1,Slfn1,SLFN5,TCIRG1,TGFBR2,TMEM178A,TNFRSF1A,TNFRSF1B,TNFSF11,TNFSF12,TP73,TYROBP",44]
["Abnormal function of immune system",7.0600000000000002E-6," "," ","C3AR1,CD22,CD274,FUT7,ICAM1,IL21R,IRF1,LILRB4,LTBR,NFATC1,NOD1,RELB,SEMA4B,TCIRG1,TLR9,TNFRSF1A,TNFRSF1B,TNFSF11,VAV1",19]
["Phagocytosis by macrophages",1.2E-5,"Increased",2.6579999999999999,"ABCA1,AXL,BTK,C3AR1,CD38,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,GAB2,INPP5D,RASA4,SAA1,SCARF1,SIGLEC1,SPI1,TPH1,TREM2,UCP2",20]
["Antigen presentation",1.7E-5," ",1.2829999999999999,"CD68,CD86,CTSD,CTSS,FCER1G,FCGR1A,FCGR2A,FCGR3A/FCGR3B,HSP90AA1,LILRB4,Rfx5,SCARF1,TAP1,UNC93B1",14]
["Abnormal morphology of macrophages",2.6699999999999998E-5," "," ","ACP2,ARSG,CD81,CSF1,CTSD,HFE2,ICAM1,IDUA,LIF,NAGLU,NFKB2,NR1H3,Rfx5,SPI1,TRPM2",15]
["Binding of professional phagocytic cells",2.8200000000000001E-5," ",0.626,"AXL,BTK,CSF1,CSF3R,Cxcl15,FERMT3,FUT7,GDF15,ICAM1,INPP5D,LIPG,MSR1,PAFAH1B1,PAK1,PLAU,RAC2,SPI1,TGFBR2,VAV1",19]
["Nephritis",3.1900000000000003E-5," ",-1.931,"ABCA1,ADORA2B,BAX,C1QA,CCL22,CD22,CD274,CD80,CDKN1A,CSF1,FAS,FCGR2A,FCGR3A/FCGR3B,FYN,IL21R,IRF5,LIF,MAPKAPK3,NFE2L2,NFKB2,RELB,RXRA,SCARF1,Tlr11,TLR7,TLR9,TNFRSF1A,TOP3B",28]
["Adhesion of phagocytes",3.2100000000000001E-5," ",0.53600000000000003,"BTK,CSF1,CSF3R,Cxcl15,FERMT3,GDF15,ICAM1,INPP5D,LIPG,PAFAH1B1,PAK1,PLAU,RAC2,SPI1,TGFBR2,VAV1",16]
["Morphology of phagocytes",3.2299999999999999E-5," "," ","ACP2,ARSG,BTK,CCL2,CD81,CSF1,CSF3R,CTSD,HFE2,ICAM1,IDUA,LIF,NAGLU,NFKB2,NR1H3,Rfx5,RPS6KA3,RRAS2,SPI1,Srgn,TNFAIP8L2,TNFRSF1A,TRPM2",23]
["Activation of B lymphocytes",5.8999999999999998E-5," ",0.106,"AXL,BTK,CD22,CD86,CHRNA4,FAS,INPP5D,IRF5,RELB,TLR7,TLR9,TNFAIP8L2,TPT1,TXLNA,VAV1",15]
["Inflammation of body cavity",6.9400000000000006E-5,"Decreased",-3.1240000000000001,"ABCA1,ADGRE1,ADORA2B,AREG,ARIH2,AXL,BAX,C1QA,CALCB,CCL2,CCL22,CCL3L3,CD22,CD274,CD38,CD80,CD86,CDKN1A,CLU,CREB1,CSF1,CSF2RB,CTSB,CTSS,CX3CL1,Cxcl15,FAS,FCGR2A,FCGR3A/FCGR3B,FERMT1,FYN,ICAM1,IKBKE,IL10RB,IL21R,IL6ST,INPP5D,IRF5,KLRB1,LCP2,LIF,LTBR,MAPKAPK3,MMP2,NFE2L2,NFKB2,NPC1,OLFM4,P2RY2,PLAU,Pmaip1,PROS1,RAPH1,RELB,RXRA,SCARF1,SHARPIN,SPI1,TGFBR2,TK1,Tlr11,TLR7,TLR8,TLR9,TNFAIP8L2,TNFRSF1A,TNFRSF1B,TNFSF12,TOP3B,TP53INP1,TREM2,TYROBP,VAV1,VNN1",74]
["Activation of lymphocytes",7.7899999999999996E-5," ",0.41799999999999998,"AXL,BAX,BTK,C3AR1,CCL2,CD22,CD274,CD38,CD48,CD80,CD86,CDKN1A,CHRNA4,CSF2RB,DEF6,DUSP22,FAS,FCER1G,FCGR2A,FYN,HSPD1,ICAM1,IL21R,INPP5D,IRF1,IRF5,KLRB1,LAPTM5,NFE2L2,NFKB2,PLA2G2D,RELB,SAA1,TGFBR2,TLR7,TLR9,TNFAIP8L2,TNFRSF1B,TPT1,TXLNA,VAV1",41]
["Quantity of macrophages",7.9300000000000003E-5," ",0.33,"ABCA1,ACAT1,C3AR1,CCL22,CLU,CSF1,CTSS,CX3CL1,CXCL10,FAS,GDF15,LIF,LILRB4,LIPG,LTC4S,MFAP2,NFE2L2,NFKB2,NPC1,PILRA,PLA2G2D,PLAU,RELB,SHCBP1,SPI1,TGFBR2,TNFRSF1A,TREM2,USP2",29]
["Cell movement of phagocytes",8.1199999999999995E-5,"Increased",3.1419999999999999,"BTK,C3AR1,CALCB,CCL2,CCL22,CCL3L3,CD38,CD81,CD86,CDKN1A,CSF1,CSF3R,CTSB,CTSS,CX3CL1,CXCL10,Cxcl15,FAS,FCER1G,FCGR2A,FERMT3,FLOT1,FUT7,FYN,GAS6,HCLS1,ICAM1,IKBKE,IL6ST,INPP5D,IRF5,LIMK1,LMNB1,MYO9B,NCKAP1L,NFE2L2,NPC1,PAFAH1B1,PLAU,PLTP,RAC2,SAA1,SPI1,TGFBR2,TNFAIP8L2,TNFRSF1A,TNFRSF1B,TNFSF12,TREM2,TREML2,TRPM2,TSHR,TYROBP,VAV1",54]
["Response of macrophages",9.3999999999999994E-5,"Increased",2.931,"ABCA1,AXL,BTK,C3AR1,CCL22,CD38,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,GAB2,INPP5D,RASA4,SAA1,SCARF1,SIGLEC1,SPI1,TLR9,TPH1,TREM2,UCP2",22]
["Immune response of macrophages",9.8999999999999994E-5,"Increased",2.7959999999999998,"ABCA1,AXL,BTK,C3AR1,CCL22,CD38,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,GAB2,INPP5D,RASA4,SAA1,SCARF1,SIGLEC1,SPI1,TPH1,TREM2,UCP2",21]
["Morphology of macrophages",9.9699999999999998E-5," "," ","ACP2,ARSG,CCL2,CD81,CSF1,CTSD,HFE2,ICAM1,IDUA,LIF,NAGLU,NFKB2,NR1H3,Rfx5,SPI1,TRPM2",16]
["Antigen presentation by leukocytes",1.85E-4," "," ","CD68,CD86,FCER1G,FCGR1A,FCGR2A,HSP90AA1,LILRB4,SCARF1,TAP1",9]
["Immune response of dendritic cells",1.85E-4," "," ","CD68,CD86,FCER1G,FCGR1A,FCGR2A,HSP90AA1,LILRB4,SCARF1,TAP1",9]
["Inflammatory response",1.8900000000000001E-4,"Increased",3.194,"ABHD12,ACKR2,Acp5,AOAH,ARIH2,AXL,BCL2A1,C3AR1,CALCB,CCL2,CCL22,CCL3L3,CD38,CD84,CDKN1A,CLCN7,CSF1,CSF3R,CTSS,CX3CL1,CXCL10,Cxcl15,CYP26B1,FCER1G,FCGR1A,FCGR2A,FCGR3A/FCGR3B,FLOT1,FYN,HNRNPA0,HSPD1,ICAM1,IL6ST,INPP5D,LGALS9B,LILRB4,MMP2,MYO9B,NCKAP1L,NFE2L2,NFKB2,NOTCH1,NPC1,NR1H3,ORAI3,P2RY6,PBK,PLAU,RAC2,RAPH1,SHARPIN,SPI1,TLR9,TNFAIP8L2,TNFRSF1A,TNFRSF1B,TNFSF12,TOP3B,TP73,TREM2,TREML2,TRPM2,TYROBP,VAV1,VNN1",65]
["Degranulation of mast cells",2.32E-4," ",1.111,"ADORA2B,BTK,CCL2,CCL3L3,CD300A,FCER1G,FCGR2A,FYN,GAB2,INPP5D,LCP2,LILRB4,Milr1,PAK1,PIGA,PTPN4,RAC2,VAV1",18]
["Degranulation of phagocytes",2.4600000000000002E-4," ",1.276,"ADORA2B,BTK,CCL2,CCL3L3,CD300A,FCER1G,FCGR2A,FYN,GAB2,INPP5D,LCP2,LILRB4,Milr1,PAK1,PIGA,PTPN4,RAC2,TREML2,VAV1",19]
["Immune response of T lymphocytes",2.6600000000000001E-4," ",1.3149999999999999,"AXL,BAX,C3AR1,CD274,CD86,CSF2RB,ICAM1,LCP2,MSR1,PLXNA1,TGFBR2,TLR9,TNFRSF1A,TNFRSF1B,TREML2,UCP2,VAV1",17]
["Immune response of B lymphocytes",2.9300000000000002E-4," "," ","CD80,CD86,CTSS,FAS,Rfx5,VAV1",6]
["Accumulation of memory T lymphocytes",3.6499999999999998E-4," "," ","DEF6,EZH2,FAS,IL6ST",4]
["Antibody response",4.0499999999999998E-4," ",0.51400000000000001,"AOAH,BTK,CD38,CD80,CD86,CTSS,FAS,Ggta1,HCLS1,IL6ST,LCP2,MYBL1,NFATC1,NOD1,NOTCH1,RELB,SPI1,Tlr11,TNFRSF13C,TYROBP,VAV1",21]
["Inflammation of absolute anatomical region",4.26E-4,"Decreased",-2.794,"ABCA1,ACKR2,ADGRE1,ADORA2B,ADRB2,AREG,ARIH2,AXL,BAX,C1QA,C3AR1,CALCB,CCL2,CCL22,CCL3L3,CD22,CD274,CD38,CD80,CD86,CDKN1A,CLU,CREB1,CSF1,CSF2RB,CTSB,CTSS,CX3CL1,CXCL10,Cxcl15,FAS,FCER1G,FCGR2A,FCGR3A/FCGR3B,FERMT1,FYN,GAS6,GRN,ICAM1,IKBKE,IL10RB,IL18BP,IL21R,IL6ST,INPP5D,IRF1,IRF5,JAG1,KLRB1,LCP2,LIF,LTBR,MAPKAPK3,MMP2,NFATC1,NFE2L2,NFKB2,NOTCH1,NPC1,OLFM4,P2RY2,P2RY6,PLAU,Pmaip1,PPARD,PROS1,RAPH1,RELB,RXRA,SCARF1,SHARPIN,SHCBP1,SPI1,SREBF2,TGFBR2,TK1,Tlr11,TLR7,TLR8,TLR9,TNFAIP8L2,TNFRSF1A,TNFRSF1B,TNFSF12,TOB1,TOP3B,TP53INP1,TREM2,TYROBP,VAV1,VNN1",91]
["Degranulation",4.3399999999999998E-4," ",1.08,"ADORA2B,BTK,CCL2,CCL3L3,CD300A,FCER1G,FCGR2A,FYN,GAB2,INPP5D,KLRB1,LCP2,LILRB4,Milr1,NPC1,PAK1,PIGA,PPM1F,PTPN4,RAC2,TREML2,VAV1",22]
["Recruitment of phagocytes",5.7300000000000005E-4,"Increased",3.5609999999999999,"ARRB2,C3AR1,CCL22,CCL3L3,CD274,CSF1,CXCL10,FCGR2A,FCGR3A/FCGR3B,FERMT3,FLOT1,FUT7,GAB2,ICAM1,INPP5D,IRF5,MMP2,MYO9B,NFE2L2,NOD1,NOTCH1,P2RY2,PLGRKT,RXRA,TGFBR2,TNFRSF1A,TREML2,TRPM2,UCP2,VAV1",30]
["Accumulation of lymphocytes",6.8900000000000005E-4," ",0.57199999999999995,"ACKR2,ARRB2,CCL22,CCL3L3,CD274,CD80,CD86,CXCL10,DEF6,EZH2,FAS,ICAM1,IL21R,IL6ST,NOTCH1,PPARD,SOS2,TLR9,TNFAIP8L2",19]
["Inflammation of organ",7.0200000000000004E-4,"Decreased",-2.2650000000000001,"ABCA1,ACKR2,ADGRE1,ADORA2B,AREG,ARIH2,AXL,BAX,C1QA,C3AR1,CALCB,CCL2,CCL22,CCL3L3,CD22,CD274,CD38,CD80,CD86,CDKN1A,CLU,CREB1,CSF1,CSF2RB,CTSB,CTSS,CX3CL1,CXCL10,Cxcl15,FAS,FCER1G,FCGR2A,FCGR3A/FCGR3B,FERMT1,FYN,GAS6,GRN,ICAM1,IKBKE,IL10RB,IL18BP,IL21R,IL6ST,INPP5D,IRF1,IRF5,JAG1,KLRB1,LCP2,LIF,LTBR,MAPKAPK3,MMP2,NFATC1,NFE2L2,NFKB2,NOD1,NOTCH1,NPC1,OLFM4,P2RY2,PBK,PLA2G2D,PLAU,Pmaip1,PPARD,PROS1,RAPH1,RBCK1,RELB,RXRA,SCARF1,SHARPIN,SHCBP1,SPI1,SREBF2,TGFBR2,TK1,Tlr11,TLR7,TLR8,TLR9,TNFAIP8L2,TNFRSF1A,TNFRSF1B,TNFSF12,TOB1,TOP3B,TP53INP1,TREM2,TYROBP,VAV1,VNN1",93]
["Accumulation of phagocytes",7.5199999999999996E-4," ",1.9179999999999999,"CCL2,CSF1,CX3CL1,CXCL10,FAS,FCGR2A,FCGR3A/FCGR3B,GRN,INPP5D,IRF1,IRF5,LTC4S,NPC1,PAFAH1B1,PLAU,TNFAIP8L2,TNFRSF1B,TYROBP",18]
["Cell-mediated response",7.5699999999999997E-4," ",1.3120000000000001,"AXL,C3AR1,CCL22,CD274,CD80,CD86,FCGR1A,ICAM1,IL18BP,INPP5D,IRF1,KLRB1,MAP3K3,NOD1,PLAU,RELB,Srgn,TGFBR2,TLR9,TNFRSF1A,TNFRSF1B,VAV1",22]
["Phagocytosis by bone marrow-derived macrophages",7.6300000000000001E-4," ",0.378,"AXL,BTK,DEF6,FCGR2A,INPP5D,SIGLEC1,UCP2",7]
["Accumulation of macrophages",7.8700000000000005E-4," ",1.1919999999999999,"CSF1,CX3CL1,FAS,GRN,INPP5D,IRF1,NPC1,PAFAH1B1,PLAU,TNFAIP8L2,TNFRSF1B",11]
["Accumulation of mononuclear leukocytes",8.0599999999999997E-4," ",0.753,"ACKR2,ARRB2,CCL22,CCL3L3,CD274,CD80,CD86,CXCL10,DEF6,EZH2,FAS,ICAM1,IL21R,IL6ST,NOTCH1,PPARD,SOS2,TGFBR2,TLR9,TNFAIP8L2",20]
["Glomerulonephritis",9.7999999999999997E-4," ",-1.772,"ABCA1,BAX,C1QA,CDKN1A,FAS,FYN,IL21R,IRF5,LIF,MAPKAPK3,NFE2L2,RXRA,SCARF1,TLR7,TLR9,TNFRSF1A,TOP3B",17]
["Activation of antigen presenting cells",9.8799999999999995E-4," ",0.73499999999999999,"ABHD12,AXL,BTK,CCL22,CD84,CLCN7,CSF1,CXCL10,FCER1G,FCGR1A,FCGR2A,LGALS9B,NOTCH1,NPC1,NR1H3,PILRB,PLA2G2D,RELB,TLR7,TLR9,TNFAIP8L2,TREM2,TRPM2,TYROBP,UNC93B1",25]
["Degranulation of cells",9.8999999999999999E-4," ",0.91800000000000004,"ADORA2B,BTK,CCL2,CCL3L3,CD300A,FCER1G,FCGR2A,FYN,GAB2,INPP5D,KLRB1,LCP2,LILRB4,Milr1,PAK1,PIGA,PPM1F,PTPN4,RAC2,TREML2,VAV1",21]
["Activation of phagocytes",1.0399999999999999E-3," ",0.92700000000000005,"ABHD12,AXL,BTK,CCL22,CD84,CLCN7,CSF1,CXCL10,FCER1G,FCGR2A,FCGR3A/FCGR3B,LCP2,LGALS9B,Milr1,NOTCH1,NPC1,NR1H3,PILRB,PLA2G2D,TLR7,TLR9,TNFAIP8L2,TREM2,TREML2,TRPM2,TYROBP,VAV1",27]
["Accumulation of antigen presenting cells",1.09E-3," ",0.91700000000000004,"CSF1,CX3CL1,FAS,GRN,INPP5D,IRF1,NPC1,PAFAH1B1,PLAU,TNFAIP8L2,TNFRSF1B,TYROBP",12]
["Activation of T lymphocytes",1.31E-3," ",0.373,"AXL,BAX,C3AR1,CCL2,CD274,CD38,CD48,CD80,CD86,CDKN1A,CSF2RB,DEF6,DUSP22,FAS,FCER1G,FYN,HSPD1,ICAM1,IL21R,IRF5,LAPTM5,NFE2L2,PLA2G2D,SAA1,TGFBR2,TLR7,TLR9,TNFAIP8L2,TNFRSF1B,VAV1",30]
["Abnormal morphology of microglia",1.3699999999999999E-3," "," ","ACP2,ARSG,CD81,CTSD,IDUA,SPI1",6]
["Rheumatoid arthritis",1.3799999999999999E-3," "," ","C3AR1,Ccl8,CSF2RB,CSF3R,DEF6,GRN,IL18BP,IL6ST,Ms4a6c,MS4A7,SAA1,Slfn1,SLFN5,TNFRSF1B,TNFSF11",15]
["Phagocytosis of neutrophils",1.5E-3," ",1.673,"CSF2RB,CXCL10,ICAM1,PLAU,RELB,SAA1,TREM2",7]
["Chemotaxis of granulocytes",1.5299999999999999E-3,"Increased",3.23,"C3AR1,CCL2,CCL3L3,CSF3R,CX3CL1,Cxcl15,FCER1G,FCGR2A,FLOT1,ICAM1,INPP5D,NCKAP1L,RAC2,SPI1,TREML2,VAV1",16]
["Migration of bone marrow-derived macrophages",1.7600000000000001E-3," ",1.091,"CCL2,CCL3L3,CSF1,PLAU,RAC2,TNFAIP8L2",6]
["Chemotaxis of neutrophils",1.83E-3,"Increased",3.0779999999999998,"C3AR1,CCL3L3,CSF3R,CX3CL1,Cxcl15,FCER1G,FCGR2A,FLOT1,ICAM1,INPP5D,NCKAP1L,RAC2,SPI1,TREML2,VAV1",15]
["Antibody-dependent cell-mediated cytotoxic reaction",1.8699999999999999E-3," "," ","FCGR1A,FCGR2A,VAV1",3]
["Immune complex nephritis",1.8699999999999999E-3," "," ","CD22,FAS,NFKB2",3]
["Accumulation of T lymphocytes",2.0100000000000001E-3," ",0.42299999999999999,"ACKR2,ARRB2,CCL22,CD274,CD80,CD86,CXCL10,DEF6,EZH2,FAS,IL6ST,NOTCH1,PPARD,SOS2,TLR9",15]
["Immune response of neutrophils",2.0300000000000001E-3," ",1.673,"CSF2RB,CXCL10,FCER1G,ICAM1,PLAU,RELB,SAA1,TREM2,TYROBP",9]
["Cell movement of neutrophils",2.1299999999999999E-3,"Increased",2.2160000000000002,"BTK,C3AR1,CCL3L3,CSF1,CSF3R,CTSB,CX3CL1,CXCL10,Cxcl15,FAS,FCER1G,FCGR2A,FERMT3,FLOT1,FUT7,ICAM1,IL6ST,INPP5D,LIMK1,NCKAP1L,PLTP,RAC2,SPI1,TGFBR2,TNFAIP8L2,TNFRSF1A,TNFRSF1B,TREML2,TRPM2,VAV1",30]
["Binding of blood platelets",2.3900000000000002E-3," ",0.44700000000000001,"ARRB2,FCER1G,FERMT3,FYN,GSK3B,LCP2,LIMK1,TPH1",8]
["Cell movement of bone marrow-derived macrophages",2.6900000000000001E-3," ",1.7090000000000001,"CCL2,CCL3L3,CSF1,CX3CL1,PLAU,RAC2,TNFAIP8L2",7]
[]
["adapted from QIAGEN IPA"]

{"sheet":"Cdkn1a-null","index":1,"n_rows":105,"n_cols":6,"rows_kept":105,"cut":false,"hidden":false,"merged":[]}
["Inflammatory Response Functional Category"]
["Diseases or Functions Annotation","p-Value","Predicted Activation State","Activation z-score","Molecules","# Molecules"]
["Activation of leukocytes",1.47E-27," ",1.7010000000000001,"ABHD12,APOE,B2M,BACH2,BAX,BTK,BTLA,C3AR1,C4A/C4B,Ccl2,CCL2,CCL22,CD22,CD244,CD274,CD300LD,CD38,CD3D,CD3E,CD3G,CD40,CD47,CD48,CD55,CD72,CD80,CD84,CD86,CDKN1A,CHRNA4,CLCN7,CRTAM,CSF1,CXCL10,CYBB,DDX58,DEF6,FAS,FASLG,FCER1G,FCGR1A,FCGR2A,FCGR3A/FCGR3B,FPR1,FYN,HAVCR2,HCK,HDAC7,HLA-A,HSH2D,ICAM1,IL21R,IL2RB,IL2RG,IMPDH1,INPP5D,IRF1,IRF5,IRF8,ITGAL,ITGB2,ITK,Klra7 (includes others),KLRB1,Klre1,Klrk1,LAPTM5,LAT,LAX1,LCP2,LDLR,LGALS9B,Milr1,MUC5B,MYD88,NCF1,NFE2L2,NLRC3,NR1H3,NR4A2,OSTM1,PDCD1LG2,PILRB,PLA2G2D,PPM1D,PRKCA,PRKCB,PSMB8,PSMB9,PTEN,PTPN6,REG3A,RHOH,Saa3,SAMSN1,SASH3,Skint2,SLC11A1,SLC33A1,SMARCA4,SMPD1,SNCA,SOCS1,SPN,STAT1,STAT4,SWAP70,TAB2,TLR3,TLR7,TNFAIP8L2,TNFRSF18,TNFSF10,TNFSF4,TREM2,TREML2,TRPM2,TXLNA,TYROBP,UNC93B1,USP18,VAV1,WAS",123]
["Activation of mononuclear leukocytes",7.31E-22," ",1.23,"APOE,B2M,BACH2,BAX,BTK,BTLA,C3AR1,Ccl2,CCL2,CD22,CD244,CD274,CD38,CD3D,CD3E,CD3G,CD40,CD48,CD55,CD72,CD80,CD86,CDKN1A,CHRNA4,CRTAM,DDX58,DEF6,FAS,FASLG,FCER1G,FCGR2A,FYN,HAVCR2,HDAC7,HLA-A,HSH2D,ICAM1,IL21R,IL2RB,IL2RG,IMPDH1,INPP5D,IRF1,IRF5,IRF8,ITGAL,ITGB2,ITK,Klra7 (includes others),KLRB1,Klre1,Klrk1,LAPTM5,LAT,LAX1,LDLR,MYD88,NCF1,NFE2L2,NLRC3,NR4A2,PDCD1LG2,PLA2G2D,PRKCB,PTEN,PTPN6,Saa3,SAMSN1,SASH3,Skint2,SLC33A1,SMARCA4,SMPD1,SOCS1,SPN,STAT1,STAT4,SWAP70,TAB2,TLR3,TLR7,TNFAIP8L2,TNFRSF18,TNFSF10,TNFSF4,TXLNA,VAV1,WAS",88]
["Activation of lymphocytes",1.32E-21," ",1.085,"APOE,B2M,BACH2,BAX,BTK,BTLA,C3AR1,Ccl2,CCL2,CD22,CD244,CD274,CD38,CD3D,CD3E,CD3G,CD40,CD48,CD55,CD72,CD80,CD86,CDKN1A,CHRNA4,CRTAM,DDX58,DEF6,FAS,FASLG,FCER1G,FCGR2A,FYN,HAVCR2,HDAC7,HLA-A,HSH2D,ICAM1,IL21R,IL2RB,IL2RG,IMPDH1,INPP5D,IRF1,IRF5,IRF8,ITGAL,ITGB2,ITK,Klra7 (includes others),KLRB1,Klre1,Klrk1,LAPTM5,LAT,LAX1,LDLR,MYD88,NCF1,NFE2L2,NLRC3,NR4A2,PDCD1LG2,PLA2G2D,PRKCB,PTEN,PTPN6,SAMSN1,SASH3,Skint2,SLC33A1,SMARCA4,SMPD1,SOCS1,SPN,STAT1,STAT4,SWAP70,TAB2,TLR3,TLR7,TNFAIP8L2,TNFRSF18,TNFSF10,TNFSF4,TXLNA,VAV1,WAS",87]
["Immune response of cells",1.6000000000000001E-21,"Increased",2.593,"Abcb1b,ATG3,BAX,BTK,C1QA,C3AR1,C5AR1,CASP1,Ccl2,CCL22,CD180,CD244,CD274,CD38,CD40,CD47,CD68,CD69,CD80,CD86,CD8A,CDKN1B,CH25H,CLEC6A,CNN2,CTSS,CXCL10,DDX58,DEF6,FAS,FASLG,FCER1G,FCGR1A,FCGR2A,FCGR3A/FCGR3B,GAS6,GNAS,HAVCR2,HCK,ICAM1,IL10RA,IL7,INPP5D,IRF2BP1,IRF7,IRF8,ISG15,ITGAL,ITGB2,ITGB3,ITK,KLRB1,LCP2,LILRB4,MARCH1,MEX3B,MFN1,MNT,MSR1,MUC5B,MYD88,NCF1,PDCD1LG2,PLD4,Pmaip1,PML,PNP,PROS1,PSMB8,PTEN,PTPN6,RAC2,S100A9,SIGLEC1,SIRPB1,SLC11A1,SOCS1,SPI1,SPIC,SPRY2,STAT1,SWAP70,SYT11,TAP1,TAPBP,TBX21,TLR3,TLR7,TNFRSF10A,TNFRSF18,TNFSF4,TREM2,TREML2,TREX1,TYROBP,VAV1,VCAM1,WAS",98]
["Antimicrobial response",1.2300000000000001E-20," ",1.972,"ADAMTS4,ADAR,Bst2,CD40,CD86,CD8A,CLEC4D,CLEC6A,CXCL10,Cxcl9,DDX58,DDX60,Defb4,DHX58,EIF2AK2,FCER1G,FCGR1A,HCK,HLA-A,HLA-G,Ifi27l2a/Ifi27l2b,IFIH1,IFIT1B,IFIT2,IFITM3,IFNLR1,IRF1,IRF5,IRF7,IRF8,IRGM,ISG15,ITGAX,KCNJ8,Klra7 (includes others),MFN1,MMP12,MSR1,MUC5B,Mx1/Mx2,MYD88,MYO1F,Naip1 (includes others),NCF1,NCR1,OAS1,OAS2,Oasl2,PLAC8,PLSCR1,PPM1D,RSAD2,SLAMF8,SLC11A1,SOCS1,SPN,SPRY2,STAT1,Tlr13,TLR3,TLR7,TNFSF4,VAV1",63]
["Antiviral response",6.31E-20," ",1.972,"ADAR,Bst2,CD40,CD86,CD8A,CXCL10,Cxcl9,DDX58,DDX60,DHX58,EIF2AK2,HLA-A,Ifi27l2a/Ifi27l2b,IFIH1,IFIT1B,IFIT2,IFITM3,IFNLR1,IRF1,IRF5,IRF7,ISG15,ITGAX,KCNJ8,Klra7 (includes others),MFN1,MMP12,MSR1,Mx1/Mx2,MYD88,NCR1,OAS1,OAS2,Oasl2,PLSCR1,RSAD2,SOCS1,SPN,SPRY2,STAT1,Tlr13,TLR3,TLR7,TNFSF4,VAV1",45]
["Immune response of leukocytes",3.1999999999999998E-19,"Increased",2.85,"BAX,BTK,C3AR1,C5AR1,CASP1,Ccl2,CCL22,CD180,CD274,CD38,CD40,CD47,CD68,CD69,CD80,CD86,CD8A,CDKN1B,CH25H,CLEC6A,CNN2,CTSS,CXCL10,DDX58,DEF6,FAS,FASLG,FCER1G,FCGR1A,FCGR2A,GNAS,HCK,ICAM1,IL10RA,IL7,INPP5D,IRF8,ISG15,ITGAL,ITGB2,ITGB3,ITK,KLRB1,LCP2,LILRB4,MARCH1,MEX3B,MSR1,MUC5B,MYD88,Pmaip1,PNP,PSMB8,PTEN,S100A9,SIGLEC1,SIRPB1,SPI1,SPIC,SWAP70,TAP1,TAPBP,TBX21,TLR7,TNFSF4,TREM2,TREML2,TREX1,TYROBP,VAV1,VCAM1,WAS",72]
["Activation of T lymphocytes",5.5800000000000004E-19," ",0.83099999999999996,"APOE,B2M,BACH2,BAX,BTLA,C3AR1,Ccl2,CCL2,CD244,CD274,CD38,CD3D,CD3E,CD3G,CD40,CD48,CD55,CD80,CD86,CDKN1A,CRTAM,DDX58,DEF6,FAS,FASLG,FCER1G,FYN,HAVCR2,HLA-A,HSH2D,ICAM1,IL21R,IL2RB,IL2RG,IMPDH1,IRF5,IRF8,ITGAL,ITGB2,ITK,Klra7 (includes others),LAPTM5,LAT,LAX1,LDLR,MYD88,NCF1,NFE2L2,NLRC3,NR4A2,PDCD1LG2,PLA2G2D,PTEN,PTPN6,Skint2,SLC33A1,SMARCA4,SMPD1,SOCS1,SPN,STAT1,STAT4,SWAP70,TLR7,TNFAIP8L2,TNFRSF18,TNFSF10,TNFSF4,VAV1,WAS",70]
["Cell movement of phagocytes",5.0000000000000004E-18,"Increased",4.2910000000000004,"ACKR1,ADRB3,ALOX5,APOE,BTK,C2,C3AR1,C4A/C4B,C5AR1,CALCB,CASP1,CCL17,Ccl2,CCL2,CCL22,CCL3L3,CCL4,CCL5,CCR1,CCR5,CD38,CD40,CD47,CD55,CD69,CD81,CD86,CDKN1A,CFB,CMKLR1,CNN2,COL4A1,CSF1,CTSB,CTSS,CXCL10,Cxcl11,CXCR3,CYBB,DOCK5,FAS,FASLG,FCER1G,FCGR2A,FERMT3,FPR1,FYN,GAS6,HCK,HCLS1,ICAM1,IL10RA,INPP5D,IRF5,Irgm1,ITGAL,ITGB2,ITGB3,LDLR,LIMK1,LTB,MDK,MMP12,MPP1,MYD88,MYO1F,NCF1,NCR1,NFE2L2,NINJ1,PIK3R5,PLCB3,PPM1D,PRKCA,PROCR,PTEN,PTGDS,PTPN6,RAC2,RIPOR2,S100A9,SELPLG,SERPINA1,SLAMF8,SOCS1,SPI1,SPN,SRF,STAT1,SWAP70,TLR3,TNFAIP8L2,TNFRSF18,TREM2,TREML2,TRPM2,TSHR,TYROBP,VAV1,VCAM1,WAS,XCL1",102]
["Inflammation of joint",1.8599999999999999E-16,"Increased",2.9049999999999998,"APOE,B2M,C2,C3AR1,C4A/C4B,C5AR1,CAMK2D,CASP1,Ccl2,CCL2,CCL3L3,CCL5,Ccl7,Ccl8,CCR1,CCR5,CD180,CD274,CD40,CD69,CDKN1A,CFB,CFP,CLEC4D,CLEC5A,COL9A1,CTSC,CTSS,Cxcl9,DEF6,FAS,FASLG,FCER1G,FCGR1A,FCGR2A,FCGR3A/FCGR3B,GLIPR2,GRN,HCK,HLA-A,IL18BP,IL21R,IL2RB,IL7,IRF1,LDLR,LGALS9B,LTB,MDK,MMP13,Ms4a4b (includes others),MS4A6A,Ms4a6c,MS4A7,MSR1,MYD88,NCF1,NFIX,PHC1,PILRA,PSMB9,Saa3,SLC11A1,Slfn1,SLFN12L,Slfn2,SOCS1,STAT1,STAT4,TBX21,TIA1,TNFRSF18,TNFSF10,TNFSF11,TNFSF13B,TNFSF4,TYROBP",77]
["Cell movement of neutrophils",2.0400000000000001E-16,"Increased",3.4929999999999999,"ACKR1,ADRB3,ALOX5,APOE,BTK,C2,C3AR1,C4A/C4B,C5AR1,CASP1,Ccl2,CCL3L3,CCL4,CCL5,CCR5,CD47,CD55,CD69,CFB,CMKLR1,CNN2,CSF1,CTSB,CXCL10,CYBB,DOCK5,FAS,FASLG,FCER1G,FCGR2A,FERMT3,FPR1,HCK,ICAM1,INPP5D,ITGAL,ITGB2,LIMK1,MDK,MMP12,MPP1,MYD88,MYO1F,NCF1,PIK3R5,PLCB3,PPM1D,PRKCA,PROCR,PTEN,PTPN6,RAC2,RIPOR2,S100A9,SELPLG,SERPINA1,SPI1,SPN,SRF,TLR3,TNFAIP8L2,TNFRSF18,TREML2,TRPM2,VAV1,WAS,XCL1",67]
["Quantity of phagocytes",4.6900000000000003E-16," ",0.30399999999999999,"AGR2,APOE,B2M,BCL2A1,BCL6B,C1QA,C3AR1,C4A/C4B,C5AR1,C5AR2,C6,Ccl2,CCL2,CCL22,CCL3L3,Ccl7,CCR1,CCR5,CD40,CD47,CD86,CDKN1A,CHST3,CLEC4D,CMKLR1,CNN2,CSF1,CTSB,CTSS,CXCL10,CXCR6,CYBB,FAS,FASLG,FCER1G,FCGR2A,GDF15,GNAS,GPR68,HAVCR2,HCK,ICAM1,IL2RB,IL2RG,INPP5D,IRF1,IRF4,IRF8,ITGAL,ITGB2,ITGB3,LAIR1,LDLR,LGALS9B,LIF,LILRB4,LTB,LTC4S,Ly6a (includes others),MDK,MFAP2,MMP12,MMP13,MYD88,NFE2L2,NLRC3,PIK3R5,PILRA,PLA2G15,PLA2G2D,PLAC8,PLSCR1,PML,PPM1D,PTEN,PTPN6,RAC2,S100A9,SELPLG,SERPINA1,SLC33A1,SLFN12L,SOCS1,SOX10,SPI1,STAT4,SWAP70,TBX21,TCF3,TIA1,TNFSF10,TNFSF11,TREM2,TYROBP,USP2,VCAM1,WAS,XCL1",98]
["Accumulation of leukocytes",9.2599999999999998E-15,"Increased",2.0110000000000001,"ALOX5,APOE,ARRB2,B2M,BCL2A1,C4A/C4B,C5AR1,Ccl2,CCL2,CCL22,CCL24,CCL3L3,CCL5,Ccl7,CCR1,CCR5,CD274,CD40,CD80,CD86,CMKLR1,CSF1,CTSC,CXCL10,Cxcl9,CXCR3,CYBB,DEF6,FAS,FASLG,FCGR2A,FCGR3A/FCGR3B,GRN,ICAM1,IL10RA,IL21R,IL2RG,IL7,INPP5D,IRF1,IRF4,IRF5,ITGAL,ITGAX,ITGB2,LAT,LDLR,LTC4S,MYD88,NCF1,PTEN,PTGDS,S100A9,SELPLG,SH2D2A,STAT1,TLR3,TNFAIP8L2,TNFSF10,TNFSF4,TYROBP,VCAM1",62]
["Inflammatory response",1.2599999999999999E-13,"Increased",2.5920000000000001,"ABHD12,ACKR1,Acp5,ALOX5,AOAH,APOE,BCL2A1,C3AR1,C5AR1,C5AR2,CALCB,CASP1,CCL17,Ccl2,CCL2,CCL22,CCL24,CCL3L3,CCL4,CCL5,CCR1,CCR5,CD38,CD40,CD47,CD69,CD84,CDKN1A,CLCN7,CSF1,Ctla2a/Ctla2b,CTSS,CXCL10,Cxcl9,CXCR3,CYBB,DOCK5,FASLG,FCER1G,FCGR1A,FCGR2A,FCGR3A/FCGR3B,FPR1,FYN,HAVCR2,HCK,HDAC7,ICAM1,INPP5D,ISG15,ITGAL,ITGB2,ITGB3,LAT,LDLR,LGALS9B,LILRB4,MDK,MPP1,MUC5B,MYD88,MYO1F,Naip1 (includes others),NCF1,NFE2L2,NINJ1,NLRC3,NR1H3,OSTM1,P2RY6,PIK3R5,PLA2G7,PLIN2,PPM1D,PRKCA,PTEN,PTPN6,RAC2,RAPH1,REG3A,RGS1,RIPOR2,S100A9,SASH3,SELPLG,SLAMF8,SLC11A1,SLC33A1,SNCA,SOCS1,SPI1,STAT1,STAT4,STK39,SWAP70,TBXAS1,TLR3,TNFAIP8L2,TNFSF4,TOP3B,TREM2,TREML2,TREX1,TRPM2,TYROBP,USP18,VAV1,VCAM1,VNN1,XCL1,ZBP1",111]
["Chemotaxis of leukocytes",1.5800000000000001E-13,"Increased",4.1660000000000004,"ALOX5,APOE,C3AR1,C5AR1,CCL17,Ccl2,CCL2,CCL22,CCL24,CCL3L3,CCL4,CCL5,CCR1,CCR5,CD38,CD40,CD47,CD69,CDKN1A,CSF1,CXCL10,Cxcl9,CXCR3,DOCK5,FASLG,FCER1G,FCGR2A,FPR1,FYN,HCK,ICAM1,INPP5D,ITGB2,ITGB3,LAT,LDLR,MDK,MPP1,MYD88,MYO1F,NINJ1,PIK3R5,PRKCA,PTEN,PTPN6,RAC2,RGS1,RIPOR2,S100A9,SELPLG,SLAMF8,SPI1,SWAP70,TREML2,TRPM2,VAV1,VCAM1,XCL1",58]
["Inflammation of absolute anatomical region",3.3599999999999998E-13," ",-1.369,"ACKR1,ADGRE1,ADRB2,AGR2,ALOX5,APOE,B2M,BACH2,BAX,BTLA,C1QA,C3AR1,C4A/C4B,C5AR1,C5AR2,CALCB,CASP1,CASP4,CASP7,Ccl2,CCL2,CCL22,CCL3L3,CCL5,CCR1,CCR5,CD22,CD274,CD38,CD40,CD47,CD55,CD72,CD80,CD86,CD8A,CDKN1A,CFB,CH25H,CHD4,CLEC4D,CLEC5A,CMKLR1,CSF1,CTSB,CTSS,CXCL10,CXCR3,CYBB,DDX58,EBI3,EGR2,ENO1,FAS,FASLG,FCER1G,FCGR2A,FCGR3A/FCGR3B,FERMT1,FYN,GAS6,GPR174,GRN,HAVCR2,HCST,HLA-A,HLA-E,ICAM1,IFIH1,IKZF3,IL10RA,IL10RB,IL18BP,IL21R,IL2RB,IL2RG,IL7,INPP5D,INSIG1,IRF1,IRF4,IRF5,IRF9,Irgm1,ITGAL,ITGAX,ITGB2,ITGB3,ITK,KLRB1,KLRC1,LANCL1,LAT,LCP2,LDLR,LIF,LPAR2,LTB,MAP3K1,MAPKAPK3,MDK,MMP12,MNT,Mx1/Mx2,MYD88,NCF1,NFE2L2,NINJ1,NMI,NR4A2,P2RY6,PDCD1LG2,PIP,PLCB3,Pmaip1,PON3,PRKCA,PROS1,PTEN,PTPN6,RAPH1,SH2D2A,SLC2A9,SLC33A1,SOCS1,SPI1,SPN,SREBF2,STAT1,STAT4,TBX21,TLR3,TLR7,TNFAIP8L2,TNFRSF18,TNFSF10,TNFSF13B,TNFSF4,TOB1,TOP3B,TP53BP2,TP53INP1,TREM2,TREX1,TYROBP,USP18,VAV1,VCAM1,VNN1,WAS,XCL1",151]
["Inflammation of body cavity",1.1200000000000001E-12," ",-1.5640000000000001,"ACKR1,ADGRE1,AGR2,APOE,B2M,BACH2,BAX,C1QA,C4A/C4B,C5AR1,CALCB,CASP1,CASP7,Ccl2,CCL2,CCL22,CCL3L3,CCR1,CCR5,CD22,CD274,CD38,CD40,CD47,CD55,CD72,CD80,CD86,CD8A,CDKN1A,CFB,CH25H,CHD4,CLEC4D,CLEC5A,CMKLR1,CSF1,CTSB,CTSS,CXCR3,CYBB,DDX58,EBI3,ENO1,FAS,FASLG,FCGR2A,FCGR3A/FCGR3B,FERMT1,FYN,HLA-A,ICAM1,IFIH1,IKZF3,IL10RA,IL10RB,IL21R,IL2RB,IL2RG,IL7,INPP5D,INSIG1,IRF5,ITGAL,ITGB2,ITGB3,ITK,KLRB1,KLRC1,LAT,LCP2,LDLR,LIF,LPAR2,LTB,MAP3K1,MAPKAPK3,MDK,MMP12,MNT,Mx1/Mx2,MYD88,NCF1,NFE2L2,NMI,PDCD1LG2,PIP,PLCB3,Pmaip1,PON3,PROS1,PTEN,PTPN6,RAPH1,SH2D2A,SLC2A9,SLC33A1,SOCS1,SPI1,STAT1,STAT4,TBX21,TLR3,TLR7,TNFAIP8L2,TNFRSF18,TNFSF10,TNFSF13B,TNFSF4,TOP3B,TP53INP1,TREM2,TREX1,TYROBP,VAV1,VCAM1,VNN1,WAS,XCL1",119]
["Rheumatoid arthritis",1.42E-12," ",1.1950000000000001,"C2,C3AR1,C4A/C4B,C5AR1,Ccl2,CCL5,Ccl7,Ccl8,CCR1,CCR5,CD40,CFB,CLEC4D,CTSC,DEF6,GLIPR2,GRN,HLA-A,IL18BP,IL7,LTB,MDK,Ms4a4b (includes others),MS4A6A,Ms4a6c,MS4A7,PSMB9,Saa3,Slfn1,SLFN12L,Slfn2,TNFSF11,TNFSF4",33]
["Migration of phagocytes",2E-12,"Increased",3.6429999999999998,"APOE,BTK,CALCB,CCL17,CCL2,Ccl2,CCL22,CCL3L3,CCL4,CCL5,CCR5,CD38,CD40,CD81,CNN2,COL4A1,CSF1,CTSS,CXCL10,Cxcl11,CYBB,FASLG,HCK,HCLS1,ICAM1,IL10RA,ITGAL,ITGB2,LDLR,MYD88,NCR1,NINJ1,PIK3R5,PPM1D,PTEN,PTGDS,PTPN6,RAC2,S100A9,SELPLG,SRF,SWAP70,TNFAIP8L2,TREM2,TYROBP,VAV1,WAS",47]
["Inflammation of organ",2.2699999999999998E-12," ",-0.94299999999999995,"ACKR1,ADGRE1,AGR2,ALOX5,APOE,B2M,BACH2,BAX,BTLA,C1QA,C3AR1,C4A/C4B,C5AR1,C5AR2,CALCB,CASP1,CASP4,CASP7,Ccl2,CCL2,CCL22,CCL3L3,CCL5,CCR1,CCR5,CD22,CD274,CD38,CD40,CD47,CD55,CD72,CD80,CD86,CD8A,CDKN1A,CFB,CH25H,CHD4,CLEC4D,CLEC5A,CMKLR1,CSF1,CTSB,CTSS,CXCL10,CXCR3,CYBB,DDX58,EBI3,EGR2,EIF2AK2,ENO1,FAS,FASLG,FCER1G,FCGR2A,FCGR3A/FCGR3B,FERMT1,FYN,GAS6,GPR174,GRN,HAVCR2,HCST,HLA-A,HLA-E,ICAM1,IFIH1,IKZF3,IL10RA,IL10RB,IL18BP,IL21R,IL2RB,IL2RG,IL7,INPP5D,INSIG1,IRF1,IRF4,IRF5,IRF9,Irgm1,ITGAL,ITGAX,ITGB2,ITGB3,ITK,KLRB1,KLRC1,LANCL1,LAT,LCP2,LDLR,LIF,LPAR2,LTB,MAP3K1,MAPKAPK3,MDK,MMP12,MNT,Mx1/Mx2,MYD88,NCF1,NFE2L2,NINJ1,NMI,NR4A2,PDCD1LG2,PIP,PLA2G2D,PLCB3,Pmaip1,PON3,PRKCA,PROS1,PTEN,PTPN6,RAPH1,RBCK1,S100A9,SH2D2A,SLC2A9,SLC33A1,SOCS1,SPI1,SPN,SREBF2,STAT1,STAT4,TBX21,TLR3,TLR7,TNFAIP8L2,TNFRSF18,TNFSF10,TNFSF13B,TNFSF4,TOB1,TOP3B,TP53BP2,TP53INP1,TREM2,TREX1,TYROBP,USP18,VAV1,VCAM1,VNN1,WAS,XCL1",153]
["Homing of phagocytes",1.0399999999999999E-11,"Increased",3.7829999999999999,"ALOX5,APOE,C3AR1,C5AR1,CCL2,Ccl2,CCL3L3,CCL5,CCR5,CD38,CD47,CD69,CDKN1A,CSF1,CXCR3,DOCK5,FASLG,FCER1G,FCGR2A,FPR1,FYN,HCK,ICAM1,INPP5D,ITGB2,ITGB3,LDLR,MDK,MPP1,MYD88,MYO1F,NINJ1,PIK3R5,PRKCA,PTEN,PTPN6,RAC2,RIPOR2,SELPLG,SLAMF8,SPI1,SWAP70,TREML2,TRPM2,VAV1,VCAM1,WAS,XCL1",48]
["Chemotaxis of phagocytes",2.6299999999999999E-11,"Increased",3.7829999999999999,"ALOX5,APOE,C3AR1,C5AR1,CCL2,Ccl2,CCL3L3,CCL5,CCR5,CD38,CD47,CD69,CDKN1A,CSF1,CXCR3,DOCK5,FASLG,FCER1G,FCGR2A,FPR1,FYN,HCK,ICAM1,INPP5D,ITGB2,ITGB3,LDLR,MDK,MPP1,MYD88,MYO1F,NINJ1,PIK3R5,PRKCA,PTEN,PTPN6,RAC2,RIPOR2,SELPLG,SLAMF8,SPI1,SWAP70,TREML2,TRPM2,VAV1,VCAM1,XCL1",47]
["Cell-mediated response",3.0200000000000003E-11,"Increased",2.3170000000000002,"APOE,C3AR1,C5AR1,CASP1,Ccl2,CCL22,CCL5,CCR1,CD244,CD274,CD80,CD86,CD8A,CDKN1B,CRTAM,EBI3,FCGR1A,GNAS,HAVCR2,HLA-A,HLA-G,ICAM1,IFIH1,IL10RA,IL18BP,IL2RG,INPP5D,IRF1,ITK,KLRB1,Klre1,Klrk1,MYD88,NCF1,NR4A2,PTHLH,SLC11A1,STAT4,TBX21,TLR3,TNFSF4,VAV1",42]
["Innate immune response",1.6699999999999999E-10," ",1.526,"Bst2,CD40,CLEC4D,CLEC5A,CLEC6A,DDX58,FCER1G,FPR1,HAVCR2,HLA-G,IFIH1,IFNLR1,IL2RG,IRF2BP1,LGALS9B,Mx1/Mx2,MYD88,NLRC5,PLSCR1,PML,STAT1,TBX21,Tlr13,TLR3,TLR7,TNFRSF10A,TRIM11,TRIM25,VNN1",29]
["Immune response of antigen presenting cells",1.6699999999999999E-10,"Increased",2.2349999999999999,"BTK,C3AR1,CCL22,CD38,CD47,CD68,CD86,CH25H,CLEC6A,CNN2,CTSS,DDX58,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,HCK,INPP5D,IRF8,ISG15,ITGB2,LILRB4,MARCH1,MEX3B,MUC5B,MYD88,PSMB8,PTEN,S100A9,SIGLEC1,SIRPB1,SPI1,SPIC,SWAP70,TAP1,TAPBP,TLR7,TNFSF4,TREM2,WAS",41]
["Chemotaxis of granulocytes",1.7600000000000001E-10,"Increased",3.0379999999999998,"ALOX5,C3AR1,C5AR1,CCL2,CCL24,CCL3L3,CD47,CD69,Cxcl9,DOCK5,FASLG,FCER1G,FCGR2A,FPR1,HCK,ICAM1,INPP5D,ITGB2,MDK,MPP1,MYO1F,PIK3R5,PRKCA,PTEN,PTPN6,RAC2,RIPOR2,SELPLG,SPI1,TREML2,VAV1,XCL1",32]
["Homing of neutrophils",5.5900000000000003E-10,"Increased",2.9740000000000002,"ALOX5,C3AR1,C5AR1,CCL3L3,CD47,CD69,DOCK5,FASLG,FCER1G,FCGR2A,FPR1,HCK,ICAM1,INPP5D,ITGB2,MDK,MPP1,MYO1F,PIK3R5,PRKCA,PTEN,PTPN6,RAC2,RIPOR2,SELPLG,SPI1,TREML2,VAV1,WAS,XCL1",30]
["Activation of phagocytes",8.0100000000000003E-10,"Increased",2.2519999999999998,"ABHD12,APOE,BTK,C4A/C4B,Ccl2,CCL22,CD244,CD300LD,CD40,CD84,CLCN7,CSF1,CXCL10,CYBB,FCER1G,FCGR2A,FCGR3A/FCGR3B,FPR1,HAVCR2,HCK,LCP2,LGALS9B,Milr1,MUC5B,MYD88,NR1H3,OSTM1,PILRB,PLA2G2D,PPM1D,PRKCA,PTPN6,REG3A,RHOH,Saa3,SLC11A1,SNCA,STAT1,STAT4,TLR3,TLR7,TNFAIP8L2,TREM2,TREML2,TRPM2,TYROBP,USP18,VAV1",48]
["Response of phagocytes",9.0399999999999998E-10," ",1.819,"BTK,C3AR1,CCL22,CCL5,CD38,CD47,CH25H,CLEC6A,CNN2,CXCL10,DBN1,DDX58,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,HCK,ICAM1,INPP5D,IRF8,ISG15,ITGAL,ITGB2,ITGB3,MEX3B,MUC5B,MYD88,PLCB3,PTEN,S100A9,SIGLEC1,SIRPB1,SOCS1,SPI1,SPIC,TLR3,TLR7,TREM2,TYROBP,VCAM1,WAS",42]
["Accumulation of phagocytes",9.28E-10,"Increased",2.371,"APOE,C5AR1,CCL2,Ccl2,CCL5,CCR1,CD40,CMKLR1,CSF1,CTSC,CXCL10,FAS,FASLG,FCGR2A,FCGR3A/FCGR3B,GRN,INPP5D,IRF1,IRF4,IRF5,ITGAX,ITGB2,LDLR,LTC4S,MYD88,PTGDS,S100A9,SELPLG,STAT1,TNFAIP8L2,TNFSF10,TYROBP,VCAM1",33]
["Cellular infiltration by phagocytes",1.08E-9," ",1.6220000000000001,"ACKR1,ADRB3,APOE,C2,C3AR1,C4A/C4B,C5AR1,CASP1,Ccl2,CCL2,CCL4,CCR1,CCR5,CD55,CD86,CFB,CMKLR1,CSF1,CTSB,CXCL10,CYBB,FAS,FASLG,FCER1G,GAS6,ICAM1,IRF5,ITGAL,ITGB2,LDLR,LIMK1,LTB,MDK,MMP12,MYD88,NCF1,NFE2L2,PLCB3,PPM1D,PRKCA,PROCR,PTEN,PTPN6,RAC2,SERPINA1,SOCS1,STAT1,TLR3,TNFAIP8L2,TNFRSF18,TRPM2,TSHR,VAV1,XCL1",54]
["Quantity of macrophages",1.1599999999999999E-9," ",1.9550000000000001,"APOE,B2M,C3AR1,C4A/C4B,C5AR1,Ccl2,CCL22,CCR5,CD40,CNN2,CSF1,CTSS,CXCL10,CXCR6,FAS,GDF15,GNAS,GPR68,HAVCR2,HCK,IL2RG,IRF8,ITGB2,ITGB3,LDLR,LIF,LILRB4,LTC4S,MDK,MFAP2,MMP12,MYD88,NFE2L2,PILRA,PLA2G15,PLA2G2D,PTEN,SELPLG,SLFN12L,SOCS1,SOX10,SPI1,STAT4,TBX21,TREM2,USP2",46]
["Quantity of neutrophils",1.27E-9," ",-1.74,"BCL6B,C1QA,C3AR1,C4A/C4B,C5AR1,C5AR2,C6,Ccl2,CCL2,CCL3L3,CCR5,CD40,CD47,CHST3,CMKLR1,CNN2,CSF1,CYBB,FAS,FASLG,FCGR2A,GNAS,ICAM1,IL2RB,IL2RG,INPP5D,ITGAL,ITGB2,LDLR,LGALS9B,MDK,MFAP2,MMP12,MMP13,PIK3R5,PILRA,PLAC8,PLSCR1,PML,PPM1D,RAC2,S100A9,SELPLG,SERPINA1,SLC33A1,SLFN12L,SPI1,TIA1,TNFSF10,VCAM1,WAS",51]
["Infiltration by neutrophils",1.3000000000000001E-9," ",1.474,"ACKR1,ADRB3,APOE,C2,C3AR1,C4A/C4B,C5AR1,CASP1,CCL4,CCR5,CD55,CFB,CMKLR1,CSF1,CTSB,CXCL10,FAS,FASLG,FCER1G,ICAM1,ITGAL,ITGB2,LIMK1,MDK,MMP12,MYD88,NCF1,PLCB3,PPM1D,PRKCA,PROCR,RAC2,SERPINA1,TLR3,TNFAIP8L2,TNFRSF18,TRPM2,VAV1,XCL1",39]
["Accumulation of mononuclear leukocytes",1.44E-9," ",0.11899999999999999,"APOE,ARRB2,B2M,C4A/C4B,Ccl2,CCL22,CCL3L3,CCL5,CCR1,CCR5,CD274,CD40,CD80,CD86,CMKLR1,CXCL10,CXCR3,DEF6,FAS,FASLG,ICAM1,IL10RA,IL21R,IL2RG,IL7,ITGAL,ITGB2,LAT,MYD88,PTEN,PTGDS,SH2D2A,TNFAIP8L2,TNFSF10,TNFSF4,VCAM1",36]
["Accumulation of lymphocytes",1.7599999999999999E-9," ",0.36699999999999999,"APOE,ARRB2,B2M,C4A/C4B,Ccl2,CCL22,CCL3L3,CCL5,CCR1,CCR5,CD274,CD40,CD80,CD86,CXCL10,CXCR3,DEF6,FAS,FASLG,ICAM1,IL10RA,IL21R,IL2RG,IL7,ITGAL,ITGB2,LAT,MYD88,PTEN,SH2D2A,TNFAIP8L2,TNFSF10,TNFSF4,VCAM1",34]
["Chemotaxis of neutrophils",2.0299999999999998E-9,"Increased",2.9740000000000002,"ALOX5,C3AR1,C5AR1,CCL3L3,CD47,CD69,DOCK5,FASLG,FCER1G,FCGR2A,FPR1,HCK,ICAM1,INPP5D,ITGB2,MDK,MPP1,MYO1F,PIK3R5,PRKCA,PTEN,PTPN6,RAC2,RIPOR2,SELPLG,SPI1,TREML2,VAV1,XCL1",29]
["Activation of B lymphocytes",3.65E-9," ",8.7999999999999995E-2,"APOE,BTK,CD22,CD40,CD72,CD86,CHRNA4,DDX58,FAS,HDAC7,IL2RB,INPP5D,IRF5,ITGB2,PRKCB,PTPN6,SAMSN1,TAB2,TLR3,TLR7,TNFAIP8L2,TNFSF4,TXLNA,VAV1",24]
["Phagocytosis",4.2899999999999999E-9,"Increased",2.3180000000000001,"ATG3,BTK,C1QA,C3AR1,Ccl2,CD38,CD47,CH25H,CLEC6A,CNN2,CXCL10,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,FCGR3A/FCGR3B,GAS6,HCK,ICAM1,INPP5D,IRF8,ISG15,ITGB2,MEX3B,MREG,MSR1,MUC5B,MYD88,OSTM1,PLD4,PROS1,PTEN,PTPN6,RAC2,S100A9,SIGLEC1,SIRPB1,SLC11A1,SPI1,SPIC,SYT11,TLR3,TREM2,TREML2,VAV1,WAS",47]
["Inflammation of central nervous system",5.5599999999999998E-9," ",0.91500000000000004,"ALOX5,B2M,BTLA,C3AR1,CASP1,CASP4,Ccl2,CCL3L3,CCL5,CCR1,CD274,CD40,CD47,CD80,CD86,CLEC4D,CLEC5A,CTSB,CXCL10,EBI3,EGR2,FAS,FASLG,FCER1G,FCGR2A,GAS6,GPR174,GRN,HAVCR2,HCST,HEXB,HLA-A,HLA-E,IL18BP,IL21R,IL2RG,IRF1,IRF4,IRF9,Irgm1,ITGAL,ITGAX,ITK,KLRB1,LANCL1,LCP2,LIF,MDK,MYD88,NCF1,NINJ1,NR4A2,PDCD1LG2,PRKCA,SLC33A1,SPI1,SPN,SREBF2,STAT1,STAT4,TBX21,TLR3,TNFSF10,TNFSF4,TOB1,TP53BP2,TREM2,TYROBP,USP18,VCAM1",70]
["Inflammation of respiratory system",9.3700000000000005E-9," ",-0.23100000000000001,"ACKR1,APOE,BACH2,BAX,BTLA,C5AR1,CASP1,Ccl2,CCL2,CCL22,CCL3L3,CCR1,CCR5,CD48,CD72,CD86,CH25H,CHD4,CLEC4D,CLEC5A,CMKLR1,CTSS,CXCR3,CYBB,ENO1,EOMES,FASLG,FCGR2A,HLA-A,ICAM1,IL2RG,INSIG1,ITGB3,ITK,KLRC1,LAT,LCP2,LDLR,LPAR2,LTC4S,MEN1,MMP12,MUC5B,Mx1/Mx2,MYD88,NCF1,NFE2L2,PLCB3,Pmaip1,PTEN,PTPN6,SOCS1,SPI1,STAT1,SWAP70,TBX21,TLR3,TNFAIP8L2,TNFSF4,VAV1",60]
["Phagocytosis of cells",9.5999999999999999E-9,"Increased",2.4830000000000001,"ATG3,BTK,C1QA,C3AR1,CD38,CD47,CH25H,CLEC6A,CNN2,CXCL10,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,FCGR3A/FCGR3B,GAS6,HCK,ICAM1,INPP5D,IRF8,ISG15,ITGB2,MEX3B,MSR1,MUC5B,MYD88,PLD4,PROS1,PTEN,PTPN6,RAC2,S100A9,SIGLEC1,SIRPB1,SLC11A1,SPI1,SPIC,SYT11,TLR3,TREM2,TREML2,VAV1,WAS",44]
["Morphology of phagocytes",1.3599999999999999E-8," "," ","APOE,BTK,CCL2,Ccl2,Ccl7,CCR1,CCR5,CD81,CD8A,CMKLR1,CSF1,CTSD,GLA,HCK,HEXB,ICAM1,Irgm1,ITGB2,ITK,LDLR,LIF,LTB,MARCH1,NPC2,NR1H3,PLA2G15,PPM1D,PSAP,PTGDS,SPI1,SPIC,TNFAIP8L2,TRPM2,WAS",34]
["Inflammation of urinary tract",1.42E-8," ",-1.7370000000000001,"BAX,C1QA,C4A/C4B,C5AR1,CCL22,CCR1,CD22,CD274,CD72,CD80,CD8A,CDKN1A,CFB,CSF1,CXCR3,FAS,FASLG,FCGR2A,FCGR3A/FCGR3B,FYN,IFIH1,IKZF3,IL21R,IRF5,ITGAL,LIF,MAPKAPK3,MDK,MYD88,NFE2L2,PTPN6,PTTG1,SH2D2A,SLC2A9,SLC33A1,SOCS1,TLR7,TNFSF13B,TOP3B,TREX1,VCAM1,WAS",42]
["Activation of antigen presenting cells",1.88E-8,"Increased",2.1850000000000001,"ABHD12,APOE,BTK,Ccl2,CCL22,CD244,CD40,CD84,CLCN7,CSF1,CXCL10,CYBB,FCER1G,FCGR1A,FCGR2A,HAVCR2,HCK,HLA-A,LGALS9B,MUC5B,MYD88,NR1H3,OSTM1,PILRB,PLA2G2D,PRKCA,PSMB8,PSMB9,PTPN6,REG3A,SLC11A1,SNCA,STAT1,STAT4,TLR3,TLR7,TNFAIP8L2,TREM2,TRPM2,TYROBP,UNC93B1,USP18",42]
["Engulfment by macrophages",2.1699999999999999E-8," ",1.4830000000000001,"BTK,C3AR1,CD38,CD47,CH25H,CLEC6A,CNN2,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,HCK,INPP5D,ISG15,ITGB2,MEX3B,MUC5B,MYD88,PROS1,PTEN,S100A9,SIGLEC1,SIRPB1,SPI1,SPIC,TLR3,TREM2,TREML2",29]
["Encephalitis",3.0099999999999998E-8," ",1.1739999999999999,"ALOX5,B2M,BTLA,C3AR1,CASP1,CASP4,Ccl2,CCL5,CCR1,CD274,CD40,CD47,CD80,CD86,CLEC4D,CTSB,CXCL10,EBI3,EGR2,FAS,FASLG,FCER1G,FCGR2A,GAS6,GPR174,GRN,HAVCR2,HCST,HLA-A,HLA-E,IL18BP,IL21R,IL2RG,IRF1,IRF4,IRF9,Irgm1,ITGAL,ITGAX,ITK,KLRB1,LANCL1,LCP2,LIF,MDK,MYD88,NCF1,NINJ1,NR4A2,PDCD1LG2,PRKCA,SLC33A1,SPI1,SPN,SREBF2,STAT1,STAT4,TBX21,TLR3,TNFSF10,TNFSF4,TOB1,TP53BP2,TREM2,TYROBP,USP18,VCAM1",67]
["Immune response of phagocytes",3.3500000000000002E-8,"Increased",2.0910000000000002,"BTK,C3AR1,CCL22,CD38,CD47,CH25H,CLEC6A,CNN2,CXCL10,DDX58,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,HCK,ICAM1,INPP5D,IRF8,ISG15,ITGAL,ITGB2,ITGB3,MEX3B,MUC5B,MYD88,PTEN,S100A9,SIGLEC1,SIRPB1,SPI1,SPIC,TLR7,TREM2,TYROBP,VCAM1,WAS",37]
["Phagocytosis of blood cells",4.0200000000000003E-8,"Increased",2.0329999999999999,"BTK,C3AR1,CD38,CD47,CH25H,CLEC6A,CNN2,CXCL10,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,HCK,ICAM1,INPP5D,IRF8,ISG15,ITGB2,MEX3B,MSR1,MUC5B,MYD88,PTEN,RAC2,S100A9,SIGLEC1,SIRPB1,SPI1,SPIC,TREM2,TREML2,WAS",33]
["Nephritis",4.2499999999999997E-8," ",-1.774,"BAX,C1QA,C4A/C4B,C5AR1,CCL22,CCR1,CD22,CD274,CD72,CD80,CD8A,CDKN1A,CFB,CSF1,CXCR3,FAS,FASLG,FCGR2A,FCGR3A/FCGR3B,FYN,IFIH1,IKZF3,IL21R,IRF5,ITGAL,LIF,MAPKAPK3,MDK,MYD88,NFE2L2,PTPN6,SH2D2A,SLC2A9,SOCS1,TLR7,TNFSF13B,TOP3B,TREX1,VCAM1,WAS",40]
["Accumulation of T lymphocytes",4.66E-8," ",-1E-3,"APOE,ARRB2,B2M,C4A/C4B,Ccl2,CCL22,CCL5,CCR1,CCR5,CD274,CD40,CD80,CD86,CXCL10,CXCR3,DEF6,FAS,FASLG,IL10RA,IL2RG,ITGAL,LAT,PTEN,SH2D2A,TNFSF10,TNFSF4,VCAM1",27]
["Inflammation of respiratory system component",6.8099999999999994E-8," ",-0.115,"ACKR1,APOE,BACH2,BAX,BTLA,C5AR1,CASP1,Ccl2,CCL2,CCL22,CCL3L3,CCR1,CCR5,CD48,CD72,CD86,CH25H,CHD4,CLEC4D,CLEC5A,CMKLR1,CTSS,CXCR3,CYBB,ENO1,EOMES,FASLG,FCGR2A,HLA-A,ICAM1,IL2RG,INSIG1,ITGB3,ITK,KLRC1,LAT,LCP2,LDLR,LPAR2,MEN1,MMP12,Mx1/Mx2,MYD88,NCF1,NFE2L2,PLCB3,Pmaip1,PTEN,PTPN6,SOCS1,SPI1,STAT1,SWAP70,TLR3,TNFAIP8L2,TNFSF4,VAV1",57]
["Accumulation of antigen presenting cells",7.7200000000000003E-8," ",1.5029999999999999,"APOE,C5AR1,Ccl2,CCL5,CCR1,CD40,CMKLR1,CSF1,FAS,FASLG,GRN,INPP5D,IRF1,IRF4,ITGAX,LDLR,MYD88,S100A9,STAT1,TNFAIP8L2,TYROBP",21]
["Recruitment of phagocytes",7.8300000000000006E-8,"Increased",3.569,"ACKR1,ALOX5,APOE,ARRB2,C3AR1,C5AR1,CASP1,Ccl2,CCL22,CCL3L3,CCL5,Ccl7,CCR1,CCR5,CD274,CD40,CD47,CD69,CD8A,CLEC5A,CMKLR1,CNN2,CRYAB,CSF1,CTSC,CXCL10,FASLG,FCGR2A,FCGR3A/FCGR3B,FERMT3,HCK,ICAM1,INPP5D,IRF5,ITGB2,MDK,MYD88,NFE2L2,PIK3R5,PLGRKT,PTEN,RCAN1,SLFN12L,TREML2,TRPM2,VAV1,VCAM1",47]
["Phagocytosis of leukocytes",1.0700000000000001E-7," ",1.8460000000000001,"BTK,C3AR1,CD38,CD47,CH25H,CLEC6A,CNN2,CXCL10,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,HCK,ICAM1,INPP5D,ISG15,ITGB2,MEX3B,MSR1,MUC5B,MYD88,PTEN,S100A9,SIGLEC1,SIRPB1,SPI1,SPIC,TREM2,TREML2,WAS",31]
["Antibody response",1.0700000000000001E-7," ",1.64,"ACKR1,AOAH,ARHGEF1,BACH2,BTK,BTLA,C4A/C4B,C5AR1,CASP1,CCL5,CD180,CD38,CD40,CD69,CD80,CD86,CTSS,FAS,Ggta1,HCLS1,IFIH1,IRF8,ITGAL,LCP2,LTB,MYBL1,MYD88,SASH3,SPI1,TNFSF13B,TYROBP,VAV1,WAS",33]
["Recruitment of macrophages",1.2200000000000001E-7,"Increased",2.052,"APOE,C3AR1,C5AR1,Ccl2,CCL22,CCR1,CCR5,CD274,CD40,CD8A,CLEC5A,CMKLR1,CNN2,CRYAB,CSF1,CXCL10,HCK,INPP5D,ITGB2,MDK,MYD88,NFE2L2,PLGRKT,SLFN12L,VCAM1",25]
["Glomerulonephritis",1.7700000000000001E-7," ",-1.6319999999999999,"BAX,C1QA,C4A/C4B,C5AR1,CCR1,CD72,CDKN1A,FAS,FASLG,FYN,IFIH1,IKZF3,IL21R,IRF5,ITGAL,LIF,MAPKAPK3,MYD88,NFE2L2,PTPN6,SH2D2A,SOCS1,TLR7,TNFSF13B,TOP3B,TREX1,VCAM1,WAS",28]
["Degranulation of cells",1.79E-7," ",1.2989999999999999,"BTK,C4A/C4B,CCL2,CCL3L3,CD244,CD300LD,DBN1,DOCK5,FCER1G,FCGR2A,FYN,HAVCR2,HCK,INPP5D,INPPL1,ITGB2,ITK,Klra7 (includes others),KLRB1,Klrk1,LAT,LAX1,LCP2,LILRB4,Milr1,MTMR4,MYO1F,NCR1,PTEN,PTGDS,RAC2,SWAP70,TREML2,VAV1",34]
["Antigen presentation",1.8400000000000001E-7,"Increased",2.4329999999999998,"CD68,CD86,CLEC4D,CTSD,CTSS,FCER1G,FCGR1A,FCGR2A,FCGR3A/FCGR3B,LILRB4,MARCH1,PSMB8,SWAP70,TAP1,TAP2,TAPBP,TNFSF4,UNC93B1,WAS",19]
["Immune response of T lymphocytes",2.2399999999999999E-7,"Increased",2.3929999999999998,"BAX,C3AR1,C5AR1,CASP1,Ccl2,CD274,CD40,CD69,CD86,CD8A,CDKN1B,FASLG,GNAS,ICAM1,IL10RA,IL7,ITK,LCP2,MSR1,MYD88,PNP,TAPBP,TBX21,TREML2,VAV1,WAS",26]
["Quantity of monocytes",3.0100000000000001E-7," ",-0.92600000000000005,"APOE,BCL6B,Ccl2,Ccl7,CD40,CDKN1A,CNN2,CSF1,FAS,GNAS,GPR68,ICAM1,IL2RG,INPP5D,IRF8,ITGAL,ITGB2,ITGB3,LDLR,Ly6a (includes others),MFAP2,NLRC3,PML,PTEN,SLFN12L,TBX21,VCAM1,WAS",28]
["Cell movement of dendritic cells",3.2899999999999999E-7,"Increased",2.2629999999999999,"APOE,CALCB,CCL17,Ccl2,CCL3L3,CCL4,CCL5,CCR5,CD38,CD40,CD81,CD86,CMKLR1,Cxcl11,CYBB,HCLS1,ICAM1,IL10RA,MYD88,NCR1,PTPN6,SWAP70,TRPM2,WAS",24]
["Cell movement of macrophages",3.6199999999999999E-7,"Increased",2.669,"ACKR1,APOE,C3AR1,C5AR1,CASP1,CCL2,Ccl2,CCL3L3,CCL4,CCL5,CCR1,CCR5,CDKN1A,CNN2,CSF1,CXCL10,CXCR3,FASLG,GAS6,HCK,ICAM1,IRF5,Irgm1,ITGAL,ITGB2,ITGB3,LDLR,LTB,MYD88,NFE2L2,NINJ1,PTEN,PTGDS,PTPN6,RAC2,SLAMF8,SOCS1,STAT1,TLR3,TNFAIP8L2,TREM2,TSHR,TYROBP,VCAM1",44]
["Accumulation of macrophages",4.27E-7," ",1.762,"APOE,C5AR1,Ccl2,CCL5,CCR1,CD40,CSF1,FAS,FASLG,GRN,INPP5D,IRF1,IRF4,ITGAX,LDLR,MYD88,S100A9,TNFAIP8L2",18]
["Phagocytosis of phagocytes",4.63E-7," ",1.5549999999999999,"BTK,C3AR1,CD38,CD47,CH25H,CLEC6A,CNN2,CXCL10,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,HCK,ICAM1,INPP5D,ISG15,ITGB2,MEX3B,MUC5B,MYD88,PTEN,S100A9,SIGLEC1,SIRPB1,SPI1,SPIC,TREM2,WAS",29]
["Phagocytosis by macrophages",4.7E-7," ",1.389,"BTK,C3AR1,CD38,CD47,CH25H,CLEC6A,CNN2,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,HCK,INPP5D,ISG15,ITGB2,MEX3B,MUC5B,MYD88,PTEN,S100A9,SIGLEC1,SIRPB1,SPI1,SPIC,TREM2",26]
["Response of macrophages",5.2200000000000004E-7," ",1.4710000000000001,"BTK,C3AR1,CCL22,CD38,CD47,CH25H,CLEC6A,CNN2,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,HCK,INPP5D,IRF8,ISG15,ITGB2,MEX3B,MUC5B,MYD88,PLCB3,PTEN,S100A9,SIGLEC1,SIRPB1,SOCS1,SPI1,SPIC,TLR3,TREM2",31]
["Degranulation of phagocytes",5.8999999999999996E-7," ",1.2509999999999999,"BTK,C4A/C4B,CCL2,CCL3L3,CD300LD,DBN1,DOCK5,FCER1G,FCGR2A,FYN,HAVCR2,HCK,INPP5D,INPPL1,ITGB2,ITK,LAT,LAX1,LCP2,LILRB4,Milr1,MTMR4,MYO1F,PTGDS,RAC2,SWAP70,TREML2,VAV1",28]
["Accumulation of granulocytes",1.06E-6," ",1.4870000000000001,"ALOX5,BCL2A1,CCL2,Ccl2,CCL24,Ccl7,CTSC,CXCL10,Cxcl9,FCGR2A,FCGR3A/FCGR3B,GRN,INPP5D,IRF5,ITGB2,MYD88,NCF1,PTGDS,S100A9,SELPLG,TLR3,TNFSF10",22]
["Antigen presentation by leukocytes",1.3400000000000001E-6," "," ","CD68,CD86,FCER1G,FCGR1A,FCGR2A,LILRB4,MARCH1,PSMB8,SWAP70,TAP1,TAPBP,TNFSF4,WAS",13]
["Immune response of dendritic cells",1.3400000000000001E-6," "," ","CD68,CD86,FCER1G,FCGR1A,FCGR2A,LILRB4,MARCH1,PSMB8,SWAP70,TAP1,TAPBP,TNFSF4,WAS",13]
["Morphology of macrophages",1.57E-6," "," ","APOE,CCL2,CCR1,CCR5,CD81,CMKLR1,CSF1,CTSD,GLA,HCK,HEXB,ICAM1,Irgm1,LDLR,LIF,NPC2,NR1H3,PLA2G15,PSAP,SPI1,SPIC,TRPM2",22]
["Inflammation of lung",2.2299999999999998E-6," ",0.189,"ACKR1,APOE,BACH2,BAX,CASP1,Ccl2,CCL2,CCL22,CCL3L3,CCR1,CCR5,CD72,CD86,CH25H,CHD4,CLEC4D,CLEC5A,CMKLR1,CTSS,CXCR3,CYBB,ENO1,FASLG,HLA-A,ICAM1,IL2RG,INSIG1,ITGB3,ITK,KLRC1,LAT,LCP2,LDLR,LPAR2,MMP12,Mx1/Mx2,MYD88,NCF1,NFE2L2,PLCB3,Pmaip1,PTEN,PTPN6,SOCS1,SPI1,STAT1,TLR3,TNFAIP8L2,TNFSF4,VAV1",50]
["Abnormal morphology of macrophages",2.6800000000000002E-6," "," ","APOE,CCR1,CCR5,CD81,CMKLR1,CSF1,CTSD,HCK,HEXB,ICAM1,LDLR,LIF,NPC2,NR1H3,PLA2G15,PSAP,SPI1,SPIC,TRPM2",19]
["Function of immune system",2.8499999999999998E-6," "," ","ALOX5,APOE,BCL6B,C3AR1,C4A/C4B,CCL24,CD22,CD274,CLEC4D,CRISPLD2,CYBB,EBI3,FCER1G,FCGR1A,FCGR2A,FYN,ICAM1,IL21R,IL2RG,IRF1,IRF4,LAT,LILRB4,MYD88,PDCD1LG2,PSMB9,SAC3D1,TNFSF11,VAV1,WAS",30]
["Experimental autoimmune encephalomyelitis",2.92E-6," ",1.5529999999999999,"B2M,BTLA,C3AR1,CASP1,CASP4,Ccl2,CCL5,CCR1,CD274,CD40,CD47,CD80,CD86,CLEC4D,CXCL10,EBI3,EGR2,FAS,FASLG,FCER1G,FCGR2A,GAS6,GPR174,HAVCR2,HCST,HLA-A,HLA-E,IL18BP,IL21R,IL2RG,IRF1,IRF4,Irgm1,ITGAL,ITGAX,ITK,KLRB1,LCP2,LIF,MDK,MYD88,NCF1,NINJ1,NR4A2,PDCD1LG2,PRKCA,SPI1,SPN,STAT1,STAT4,TBX21,TNFSF10,TNFSF4,TOB1,TYROBP,USP18,VCAM1",57]
["Immune response of macrophages",3.6899999999999998E-6," ",1.7330000000000001,"BTK,C3AR1,CCL22,CD38,CD47,CH25H,CLEC6A,CNN2,DEF6,FAS,FCER1G,FCGR1A,FCGR2A,HCK,INPP5D,IRF8,ISG15,ITGB2,MEX3B,MUC5B,MYD88,PTEN,S100A9,SIGLEC1,SIRPB1,SPI1,SPIC,TREM2",28]
["Degranulation of mast cells",3.8E-6," ",1.2889999999999999,"BTK,C4A/C4B,CCL2,CCL3L3,CD300LD,DBN1,DOCK5,FCER1G,FCGR2A,FYN,HAVCR2,HCK,INPP5D,INPPL1,ITK,LAT,LAX1,LCP2,LILRB4,Milr1,MTMR4,PTGDS,RAC2,SWAP70,VAV1",25]
["Chemotaxis of macrophages",5.0599999999999998E-6,"Increased",2.7429999999999999,"APOE,C3AR1,C5AR1,CCL2,Ccl2,CCL3L3,CCL5,CCR5,CDKN1A,CSF1,CXCR3,FASLG,HCK,ICAM1,ITGB3,LDLR,MYD88,NINJ1,SLAMF8,VCAM1",20]
["Recruitment of neutrophils",5.6799999999999998E-6,"Increased",3.4159999999999999,"ACKR1,ALOX5,APOE,ARRB2,C3AR1,C5AR1,CASP1,CCL3L3,Ccl7,CCR1,CD274,CD47,CD69,CD8A,CLEC5A,CSF1,CTSC,CXCL10,FASLG,FCGR2A,FCGR3A/FCGR3B,FERMT3,HCK,ICAM1,ITGB2,MDK,MYD88,PIK3R5,PTEN,RCAN1,TREML2,TRPM2,VAV1",33]
["Antibacterial response",5.9399999999999999E-6," "," ","ADAMTS4,CLEC4D,Defb4,FCER1G,FCGR1A,HCK,HLA-A,HLA-G,IRF8,IRGM,ISG15,MUC5B,MYO1F,Naip1 (includes others),NCF1,PLAC8,PPM1D,SLAMF8,SLC11A1,SPN,STAT1",21]
["Inflammation of liver",6.4300000000000003E-6," ",-0.91,"ACKR1,APOE,C4A/C4B,CASP1,CASP7,CCL22,CCL3L3,CCR5,CD55,FAS,FASLG,HLA-A,IL2RB,ITGB2,KLRB1,KLRC1,LAT,LCP2,LDLR,LTB,NFE2L2,PON3,PTEN,SOCS1,SPI1,STAT1,STAT4,TBX21,TLR3,TLR7,TNFAIP8L2,TNFRSF18,TNFSF10,TYROBP,XCL1",35]
["Migration of dendritic cells",6.99E-6," ",1.556,"APOE,CALCB,CCL17,CCL3L3,CCL5,CD38,CD40,CD81,Cxcl11,HCLS1,ICAM1,IL10RA,MYD88,NCR1,PTPN6,SWAP70,WAS",17]
["Abnormal function of immune system",7.9400000000000002E-6," "," ","ALOX5,APOE,BCL6B,C3AR1,C4A/C4B,CCL24,CD22,CD274,CLEC4D,CRISPLD2,CYBB,EBI3,ICAM1,IL21R,IRF1,IRF4,LILRB4,MYD88,PDCD1LG2,PSMB9,TNFSF11,VAV1",22]
["Quantity of dendritic cells",8.4400000000000005E-6," ",0.95399999999999996,"BCL2A1,CCL2,Ccl2,CD47,CD86,CLEC4D,CSF1,FCER1G,IL2RG,INPP5D,IRF1,IRF4,IRF8,ITGB2,LAIR1,LDLR,LTB,MDK,MYD88,PLA2G2D,PTPN6,SOCS1,SPI1,TCF3,TNFSF11,TYROBP,XCL1",27]
["Binding of professional phagocytic cells",1.1800000000000001E-5,"Increased",2.0219999999999998,"ADGRB1,BTK,CSF1,CYBB,FASLG,FERMT3,FPR1,GDF15,HCK,ICAM1,INPP5D,Irgm1,ITGAL,ITGAX,ITGB2,MSR1,PLCB3,PTPN6,RAC2,SELPLG,SPI1,VAV1,VCAM1",23]
["Respiratory burst of myeloid cells",1.1800000000000001E-5," ",1.23,"CCL22,FCER1G,HCK,ICAM1,IRF8,ITGAL,ITGB2,ITGB3,TYROBP,VCAM1",10]
["Respiratory burst of phagocytes",1.1800000000000001E-5," ",1.23,"CCL22,FCER1G,HCK,ICAM1,IRF8,ITGAL,ITGB2,ITGB3,TYROBP,VCAM1",10]
["Migration of macrophages",1.26E-5,"Increased",2.964,"CCL2,Ccl2,CCL3L3,CCL4,CCL5,CCR5,CNN2,CSF1,CXCL10,ITGAL,NINJ1,PTGDS,RAC2,TNFAIP8L2,TREM2,TYROBP",16]
["Immune response of B lymphocytes",1.5500000000000001E-5," ",1.3420000000000001,"CD180,CD69,CD80,CD86,CTSS,FAS,VAV1,VCAM1",8]
["Migration of neutrophils",1.59E-5,"Increased",2.2669999999999999,"BTK,Ccl2,CCL3L3,CCL5,CNN2,CYBB,FASLG,HCK,ITGAL,ITGB2,MYD88,PIK3R5,PPM1D,PTEN,PTPN6,S100A9,SELPLG,SRF,VAV1",19]
["Activation of macrophages",1.9700000000000001E-5,"Increased",2.4079999999999999,"ABHD12,APOE,Ccl2,CCL22,CD40,CD84,CLCN7,CSF1,CXCL10,CYBB,FCER1G,HAVCR2,HCK,LGALS9B,MUC5B,MYD88,NR1H3,OSTM1,PTPN6,REG3A,SLC11A1,SNCA,STAT1,STAT4,TNFAIP8L2,TREM2,TRPM2,TYROBP,USP18",29]
["Chemotaxis of antigen presenting cells",2.0699999999999998E-5,"Increased",2.9140000000000001,"APOE,C3AR1,C5AR1,CCL2,Ccl2,CCL3L3,CCL5,CCR5,CD38,CDKN1A,CSF1,CXCR3,FASLG,HCK,ICAM1,ITGB3,LDLR,MYD88,NINJ1,SLAMF8,TRPM2,VCAM1",22]
["Adaptive immune response",2.2799999999999999E-5,"Increased",2.2160000000000002,"C3AR1,CLEC4D,CXCR6,FCGR1A,FCGR2A,GLT8D2,IFNLR1,IL2RG,ITK,KLHL6,LGMN,MYD88,PDCD1LG2,PLCL2,TXK",15]
["Cytotoxic reaction of lymphocytes",3.4799999999999999E-5,"Increased",2,"FASLG,FCGR2A,PNP,VAV1",4]
["Immune response of neutrophils",5.94E-5," ",1.107,"CD47,CLEC6A,CXCL10,FCER1G,HCK,ICAM1,ITGAL,ITGB2,ITGB3,TREM2,TYROBP,VCAM1,WAS",13]
["Cellular infiltration by macrophages",6.2000000000000003E-5," ",0.90700000000000003,"ACKR1,APOE,C5AR1,CASP1,CCL2,Ccl2,CCL4,CCR1,CCR5,CSF1,CXCL10,GAS6,ICAM1,IRF5,ITGB2,LDLR,LTB,MYD88,NFE2L2,PTEN,PTPN6,RAC2,SOCS1,STAT1,TLR3,TNFAIP8L2,TSHR",27]
["Influx of neutrophils",6.6299999999999999E-5," ",1.726,"CASP1,Ccl2,CCL2,CTSC,CYBB,FCGR2A,IRF4,IRF7,MSR1,MYD88,PTEN,SERPINA1",12]
["Adhesion of phagocytes",6.6799999999999997E-5," ",0.96199999999999997,"BTK,CSF1,CYBB,FERMT3,GDF15,HCK,ICAM1,INPP5D,Irgm1,ITGAL,ITGAX,ITGB2,PLCB3,PTPN6,RAC2,SPI1,VAV1,VCAM1",18]
["Activation of natural killer T lymphocytes",6.7399999999999998E-5,"Increased",2.2360000000000002,"B2M,CD80,DDX58,ITGAL,STAT1,VAV1",6]
[]
["adapted from QIAGEN IPA"]

{"sheet":"Trp53-null","index":2,"n_rows":27,"n_cols":6,"rows_kept":27,"cut":false,"hidden":false,"merged":[]}
["Inflammatory Response Functional Category"]
["Diseases or Functions Annotation","p-Value","Predicted Activation State","Activation z-score","Molecules","# Molecules"]
["Antiviral response",3.8799999999999996E-12,null,null,"ADAR,DHX58,EIF2AK2,Fv1,IFIH1,IFIT1B,IFIT2,IRF7,ISG15,Mx1/Mx2,RSAD2,STAT1,TRIM56",13]
["Antimicrobial response",5.29E-11,null,null,"ADAR,BPIFA1,DHX58,EIF2AK2,Fv1,IFIH1,IFIT1B,IFIT2,IRF7,IRGM,ISG15,Mx1/Mx2,RSAD2,STAT1,TRIM56",15]
["Innate immune response",7.6799999999999997E-5,null,null,"BPIFA1,IFIH1,Mx1/Mx2,PML,STAT1,TRIM56",6]
["Antibacterial response",4.4400000000000004E-3,null,null,"BPIFA1,IRGM,ISG15,STAT1",4]
["Host defense of fibroblasts",7.1399999999999996E-3,null,null,"PML",1]
["CD4 T-cell response of T lymphocytes",1.4200000000000001E-2,null,null,"CASP1",1]
["Cellulitis of eye",1.4200000000000001E-2,null,null,"STAT1",1]
["Inflammation of iris",1.4200000000000001E-2,null,null,"STAT1",1]
["Inflammation of peribronchial tissue",1.4200000000000001E-2,null,null,"BPIFA1",1]
["Relocalization of marginal-zone B lymphocytes",1.4200000000000001E-2,null,null,"CR2",1]
["Experimental colitis",2.0199999999999999E-2,null,null,"CASP1,CR2,STAT1",3]
["Accumulation of plasmacytoid dendritic cells",2.1299999999999999E-2,null,null,"STAT1",1]
["Antiviral response of fibroblasts",2.1299999999999999E-2,null,null,"STAT1",1]
["Chronic inflammation of joint",2.1299999999999999E-2,null,null,"STAT1",1]
["Phagocytic capacity of peritoneal macrophages",2.1299999999999999E-2,null,null,"ISG15",1]
["Antibody response",2.6700000000000002E-2,null,null,"CASP1,CR2,IFIH1,JCHAIN",4]
["Lupus-like autoimmune nephritis",2.8199999999999999E-2,null,null,"IFIH1",1]
["Phagocytosis of embryonic cell lines",2.8199999999999999E-2,null,null,"ISG15",1]
["Cytotoxic T lymphocyte response",3.0099999999999998E-2,null,null,"CASP1,IFIH1",2]
["Fusion of foreign body giant cell",3.5200000000000002E-2,null,null,"STAT1",1]
["Influx of monocytes",3.5200000000000002E-2,null,null,"CASP1",1]
["Influx of neutrophils",3.7699999999999997E-2,null,null,"CASP1,IRF7",2]
["Acute colitis",4.8899999999999999E-2,null,null,"CASP1",1]
[]
["adapted from QIAGEN IPA"]