Fig. S1. Floxed and knockout alleles of TPL2. Fig. S2. TPL2 knockout mice (TPL2-KO) display significantly reduced gene synthesis of TPL2 and IL-1β. Fig. S3. TcdB induces production of proinflammatory cytokines by bone marrow-derived macrophages. Fig. S4. TPL2-specific inhibitor significantly inhibits production of proinflammatory cytokines/chemokines by bone marrow-derived macrophages. Fig. S5. TPL2 knockout reduces TcdB-induced production of proinflammatory cytokines/chemokines by bone marrow-derived macrophages. Fig. S6. TPL2 inhibition reduces activation of MAPK in bone marrow-derived macrophages. Fig. S7. TPL2 knockout reduced activation of MAPK in bone marrow-derived macrophages. Fig. S8. MAPK-specific inhibitors significantly inhibit production of proinflammatory cytokines/chemokines by bone marrow-derived macrophages.
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