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["Supplementary Table S3: Examples of Trichoplax sp. H2 CDS showing dN/dS values above 1.5*"]
[]
["locus_tag in H2","dN/dS","Best SwissProt Hit"]
["TrispH2_009933-RA",139,"PFY1 Profilin (Candida albicans) "]
["TrispH2_005000-RA",135,"NKX6-2 Homeobox protein Nkx-6.2 (Homo sapiens) "]
["TrispH2_003524-RA",130,"Eid3 EP300-interacting inhibitor of differentiation 3 (Mus musculus) "]
["TrispH2_002854-RA",107,"TRYP4 Trypsin-4 (Anopheles gambiae) "]
["TrispH2_007091-RA",106,"HIGD2A HIG1 domain family member 2A, mitochondrial (Homo sapiens) "]
["TrispH2_008637-RA",104,"txndc17 Thioredoxin domain-containing protein 17 (Danio rerio) "]
["TrispH2_003493-RA",100,"SNAPIN SNARE-associated protein Snapin (Homo sapiens) "]
["TrispH2_003664-RA",96,"Paip1 Polyadenylate-binding protein-interacting protein 1 (Mus musculus) "]
["TrispH2_007407-RA",93,"KREMEN1 Kremen protein 1 (Homo sapiens) "]
["TrispH2_007660-RA",87,"Hnrnpab Heterogeneous nuclear ribonucleoprotein A/B (Mus musculus) "]
["TrispH2_000162-RA",84,"UPF0598 protein C8orf82 homolog (Bos taurus) "]
["TrispH2_007360-RA",84,"Litaf Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog (Rattus norvegicus) "]
["TrispH2_002752-RA",82,"SLC45A4 Solute carrier family 45 member 4 (Homo sapiens) "]
["TrispH2_007770-RA",82,"Dda1 DET1- and DDB1-associated protein 1 (Mus musculus) "]
["TrispH2_001061-RA",81,"S1pr1 Sphingosine 1-phosphate receptor 1 (Rattus norvegicus) "]
["TrispH2_001425-RA",76,"RMI2 RecQ-mediated genome instability protein 2 (Gallus gallus) "]
["TrispH2_000752-RA",76,"VIMP Selenoprotein S (Sus scrofa) "]
["TrispH2_003889-RA",75,"DEAF1 Deformed epidermal autoregulatory factor 1 homolog (Pan troglodytes) "]
["TrispH2_008657-RA",74,"dctn6 Dynactin subunit 6 (Danio rerio) "]
["TrispH2_010750-RA",72,"Cyt-b5 Cytochrome b5 (Drosophila melanogaster) "]
["TrispH2_000038-RA",72,"isoc2 Isochorismatase domain-containing protein 2 (Xenopus laevis) "]
["TrispH2_009680-RA",70,"trmH tRNA (guanosine(18)-2'-O)-methyltransferase (Borrelia burgdorferi (strain ATCC 35210 / B31 / CIP 102532 / DSM 4680)) "]
["TrispH2_009932-RA",70,"Profilin-2 (Acanthamoeba castellanii) "]
["TrispH2_002817-RA",70,"Pop5 Ribonuclease P/MRP protein subunit POP5 (Mus musculus) "]
["TrispH2_003225-RA",69,"chac2 Putative glutathione-specific gamma-glutamylcyclotransferase 2 (Gallus gallus) "]
["TrispH2_000268-RA",69,"COMMD8 COMM domain-containing protein 8 (Homo sapiens) "]
["TrispH2_005024-RA",69,"nrv1 Sodium/potassium-transporting ATPase subunit beta-1 (Drosophila melanogaster) "]
["TrispH2_005279-RA",68,"dbx1b Homeobox protein DBX1-B (Danio rerio) "]
["TrispH2_002277-RA",67,"Chn1 N-chimaerin (Mus musculus) "]
["TrispH2_008489-RA",64,"adra1a Alpha-1A adrenergic receptor (Oryzias latipes) "]
["TrispH2_011227-RA",63,"Uncharacterized protein C1orf43 homolog (Mus musculus) "]
["TrispH2_006567-RA",63,"MCFD2 Multiple coagulation factor deficiency protein 2 homolog (Pongo abelii) "]
["TrispH2_002131-RA",61,"UPF0235 protein C15orf40 homolog (Mus musculus) "]
["TrispH2_009775-RA",60,"Drap1 Dr1-associated corepressor (Mus musculus) "]
["TrispH2_004006-RA",60,"COLGALT1 Procollagen galactosyltransferase 1 (Bos taurus) "]
["TrispH2_008466-RA",59,"GNG7 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 (Homo sapiens) "]
["TrispH2_004042-RA",58,"COA4 Cytochrome c oxidase assembly factor 4 homolog, mitochondrial (Mus musculus) "]
["TrispH2_005460-RA",58,"Pttg1ip Pituitary tumor-transforming gene 1 protein-interacting protein (Mus musculus) "]
["TrispH2_008491-RA",57,"PROKR2 Prokineticin receptor 2 (Bos taurus) "]
["TrispH2_001607-RA",57,"RBM18 Probable RNA-binding protein 18 (Pongo abelii) "]
["TrispH2_001262-RA",55,"ARPP19 cAMP-regulated phosphoprotein 19 (Bos taurus) "]
["TrispH2_003128-RA",54,"lrrc57 Leucine-rich repeat-containing protein 57 (Xenopus laevis) "]
["TrispH2_007895-RA",51,"msrA Peptide methionine sulfoxide reductase MsrA (Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)) "]
["TrispH2_001099-RA",51,"RNF219 RING finger protein 219 (Pongo abelii) "]
["TrispH2_000356-RA",50,"TTC9 Tetratricopeptide repeat protein 9A (Homo sapiens) "]
["TrispH2_000047-RA",50,"slc35e3 Solute carrier family 35 member E3 (Danio rerio) "]
["TrispH2_009413-RA",18,"MARK3 MAP/microtubule affinity-regulating kinase 3 (Homo sapiens) "]
["TrispH2_008974-RA","3.29","Blue-sensitive opsin (Anolis carolinensis) "]
["TrispH2_007459-RA","3.26","chuk Inhibitor of nuclear factor kappa-B kinase subunit alpha (Danio rerio) "]
["TrispH2_000740-RA","3.23","nsmce2 E3 SUMO-protein ligase NSE2 (Xenopus laevis) "]
["TrispH2_008686-RA","3.22","LYK5 Protein LYK5 (Arabidopsis thaliana) "]
["TrispH2_005492-RA","2.71","Npffr1 Neuropeptide FF receptor 1 (Rattus norvegicus) "]
["TrispH2_003552-RA","2.67","ADGRD1 Adhesion G-protein coupled receptor D1 (Bos taurus) "]
["TrispH2_002831-RA","2.63","Casp7 Caspase-7 (Mus musculus) "]
["TrispH2_007460-RA","2.63","Wnk1 Serine/threonine-protein kinase WNK1 (Mus musculus) "]
["TrispH2_001813-RA","2.55","RB1CC1 RB1-inducible coiled-coil protein 1 (Homo sapiens) "]
["TrispH2_007914-RA","2.50","tbrg4 Protein TBRG4 (Xenopus laevis) "]
["TrispH2_007160-RA","2.50","RAD17 Cell cycle checkpoint protein RAD17 (Pongo abelii) "]
["TrispH2_010442-RA","2.48","enthd2 AP-4 complex accessory subunit tepsin (Xenopus laevis) "]
["TrispH2_008949-RA","2.38","Grpr Gastrin-releasing peptide receptor (Rattus norvegicus) "]
["TrispH2_005099-RA","2.38","Galr2 Galanin receptor type 2 (Rattus norvegicus) "]
["TrispH2_005263-RA","2.37","ADRA1B Alpha-1B adrenergic receptor (Homo sapiens) "]
["TrispH2_004170-RA","2.21","Suco SUN domain-containing ossification factor (Mus musculus) "]
["TrispH2_009091-RA","2.15","Fam63a Protein FAM63A (Rattus norvegicus) "]
["TrispH2_000024-RA","2.14","Smad6 Mothers against decapentaplegic homolog 6 (Mus musculus) "]
["TrispH2_001269-RA","2.13","D(1)-like dopamine receptor (Oreochromis mossambicus) "]
["TrispH2_002997-RA","2.09","Smc5 Structural maintenance of chromosomes protein 5 (Mus musculus) "]
["TrispH2_009683-RA","2.09","UBN1 Ubinuclein-1 (Homo sapiens) "]
["TrispH2_010546-RA","2.03","Ints3 Integrator complex subunit 3 (Mus musculus) "]
["TrispH2_002122-RA","1.98","Fst Follistatin (Mus musculus) "]
["TrispH2_010979-RA","1.98","bmt5 25S rRNA (uridine-N(3))-methyltransferase (Schizosaccharomyces pombe (strain 972 / ATCC 24843)) "]
["TrispH2_005391-RA","1.95","DDX21 Nucleolar RNA helicase 2 (Homo sapiens) "]
["TrispH2_006309-RA","1.88","EPHX2 Bifunctional epoxide hydrolase 2 (Sus scrofa) "]
["TrispH2_001015-RA","1.86","Peak1 Pseudopodium-enriched atypical kinase 1 (Mus musculus) "]
["TrispH2_009878-RA","1.78","papd4 Poly(A) RNA polymerase GLD2 (Danio rerio) "]
["TrispH2_004268-RA","1.73","CCDC181 Coiled-coil domain-containing protein 181 (Macaca fascicularis) "]
["TrispH2_004150-RA","1.70","Golga2 Golgin subfamily A member 2 (Rattus norvegicus) "]
["TrispH2_011352-RA","1.68","Cyp4b1 Cytochrome P450 4B1 (Rattus norvegicus) "]
["TrispH2_008278-RA","1.68","npy1r Neuropeptide Y receptor type 1 (Xenopus laevis) "]
["TrispH2_009999-RA","1.63","BPHL Valacyclovir hydrolase (Homo sapiens) "]
["TrispH2_009648-RA","1.61","Kpna3 Importin subunit alpha-4 (Mus musculus) "]
["TrispH2_002735-RA","1.58","Ube2o (E3-independent) E2 ubiquitin-conjugating enzyme UBE2O (Mus musculus) "]
["TrispH2_003705-RA","1.52","Vertebrate ancient opsin (Salmo salar) "]
["TrispH2_007616-RA","1.52","TTC28 Tetratricopeptide repeat protein 28 (Homo sapiens) "]
[]
["*Of the inital 225 CDS those were excluded that showed more than 1% length difference to their putative orthologs in Trichoplax adhaerens or an alignment gap longer than one amino acid in order to minimize false positives as a result of mere differences in gene model calls. This resulted in 143 CDS of which 84 received a SwissProt hit (cut-off 1e-5) and are listed bbovelaow."]