This PDF file includes:

• Fig. S1. MIA induces mechanical allodynia in rats.
• Fig. S2. ATF3 and CSF1 expression in L3-L5 DRG is comparable in sham and MIA joint-injured rats on day 7.
• Fig. S3. Microglial proliferation and Mac1-saporin depletion of spinal microglia.
• Fig. S4. Characterization of microglial Panx1-deficient mice.
• Fig. S5. Dynamic weight-bearing baseline quantification.
• Fig. S6. Probenecid does not alter primary joint afferent activity.
• Fig. S7. Probenecid alleviates ACLx-induced joint pain.

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