The PDF file includes:

• Supplementary Materials and Methods
• Fig. S1. TLK2 is required for efficient DNA replication.
• Fig. S2. TLK2 is required for replication-coupled chromatin assembly.
• Fig. S3. Sustained depletion of TLK activity leads to DNA damage and checkpoint-induced G₁ arrest.
• Fig. S4. TLK2 depletion causes genomic instability that is amplified by checkpoint and PARP inactivation.
• Fig. S5. Analysis of TLK status in cancer.
• Legends for tables S1 to S5
• References (44, 45)

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Other Supplementary Material for this manuscript includes the following:

• Table S1 (Microsoft Excel format). TCGA cohort designations.
• Table S2 (Microsoft Excel format). Chromosome locations of genes analyzed.
• Table S3 (Microsoft Excel format). Analysis of correlated gene expression.
• Table S4 (Microsoft Excel format). Survival analysis of TCGA patient data.
• Table S5 (Microsoft Excel format). Multivariate survival analysis of TCGA patient data.

Download Tables S1 to S5