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{"sheet":"pluripotency","index":0,"n_rows":41,"n_cols":5,"rows_kept":41,"cut":false,"hidden":false,"merged":[]}
["Percentage of cells expressing markers associated with pluripotency and metabolic regulation"]
[]
[null,"TESR-E8","StemFlex",null,"Function"]
["Core pluripotency factors"]
["POU5F1",89.3353744100013,91.0005334146156]
["NANOG",18.1273121571629,19.5077345119256]
["SOX2",73.2874091083046,75.9125200030481]
[]
["Naive pluripotency markers"]
["SALL4",22.8090317642556,24.1179608321268,null,"regulates OCT4 expression, OCT4 binding"]
["ZFP42/REX1",22.1074116596505,23.1654347329117,null,"regulates OCT4 expression, OCT4 binding"]
["CDH1",19.2499043245312,20.4831212375219,null,"Control of epithelial-to-mesenchymal transition"]
["TCL1B",2.66615639749968,3.2385887373314]
["DPPA2",2.58961602245184,2.7280347481521]
["LIFR",2.43653527235617,2.45370723157815]
["PRDM14",2.30896798060977,2.59849119865884,null,"Antagonizing FGFR-mediated signalling, represses gene expression via association with PRC2"]
["UTF1",2.23242760556193,2.68231349538977,null,"regulates OCT4 expression, OCT4 binding"]
["POU3F1",2.20691414721265,1.86695115446163]
["IL6ST/CD130",1.18637581324148,1.50880134115675]
["DPPA5",0.854700854700855,0.822982549721862,null,"NANOG turnover"]
["KLF4",0.701620104605179,0.96776651680256]
["NR5A2/LRH1",0.68886337543054,0.777261296959537,null,"stimulates OCT-4 expression, OCT4 binding, cholesterol metabolism"]
["CD7",0.625079729557342,0.716299626609769]
["KLF5",0.33167495854063,0.342909395717443,null,"regulates OCT4 expression, OCT4 binding"]
["TFCP2L1",0.204107666794234,0.297188142955117]
["TCL1A",0.178594208444955,0.121923340699535]
["DPPA3/ STELLA",0.0892971042224774,0.144783967080698]
[]
["Transition from naive to primed state"]
["OTX2",18.9309860951652,20.9250933475577,null,"regulates OCT4 expression, OCT4 binding"]
["FOXD3",2.56410256410256,3.0176026823135,null,"regulates OCT4 expression, OCT4 binding"]
["FGF4",0.127567291746396,0.114303131905814,null,"regulates OCT4 expression, OCT4 binding"]
[]
["Others"]
["CD9",60.5,63.1,null,"Additional genes encoding cell surface proteins known to be expressed in pluripotent stem cells as described in O’Brien et al, Stem Cells 2017"]
["DGS2",28.2,29.8]
["NLGN4X",22.3,23.2]
["F11R",15.9,17.3]
["CDH3",11.6,12.0]
["PCDH1",10.8,10.8]
["CDCP1",2.7,2.7]

{"sheet":"proliferation and survival","index":1,"n_rows":56,"n_cols":5,"rows_kept":56,"cut":false,"hidden":false,"merged":[]}
[]
[null,"TESR-E8","StemFlex",null,"Function"]
[]
["Inhibition of BMP signalling"]
["GDF3",4.1204235234086,4.3282785948335]
["NODAL",0.956754688097972,1.26495465975768]
["NOG",0.127567291746396,0.137163758286977]
[]
["Inhibition of Nodal signalling"]
["LEFTY1",3.06161500191351,3.45195458355559]
["LEFTY2",1.70940170940171,2.11841804465442]
[]
["Regulation of STAT3 signalling"]
["GRB7",5.58744737849215,6.69054332088699]
["LIFR",2.43653527235617,2.45370723157815]
["GBX2",2.21967087638729,2.17175950621047]
["KIT/CD117",1.95177956371986,2.37750514364094]
["IL6ST",1.18637581324148,1.50880134115675]
[]
["Regulation of NF-kB activity"]
["LCK",20.5638474295191,22.9444486778938]
["COMMD3",4.17145044010716,3.82534481444792]
[]
["Regulation of PI3K/Akt signalling"]
["PODXL",50.5931879066207,53.3795626000152]
["REST",30.4885827273887,31.9896365160405]
["PTEN",13.5093761959434,15.8347938733521]
[]
["Regulation of retinoic acid-mediated signalling"]
["NR6A1",61.9084066845261,64.1621580431304,null,"repression of OCT4 expression upon RA-induced differentiation, germ cell development"]
["CRABP2",50.4528638856997,54.7130991389164]
[]
["Regulation of Wnt signalling"]
["SFRP2",78.1477229238423,79.6921435647337]
["TCF3",15.4228855721393,17.5874418959079]
[]
["de novo DNA methylation"]
["DNMT3B",41.663477484373,45.2869008610836]
[]
["Cell proliferation"]
["DPPA2",2.58961602245184,2.7280347481521]
["CXCL5",1.4797805842582,1.2725748685514,null,"Control of epithelial-to-mesenchymal transition"]
["FGF4",0.127567291746396,0.114303131905814]
[]
["Maintenance of pluripotency"]
["THAP11/RONIN",21.4568184717438,23.157814524118]
["CDH1",19.2499043245312,20.4831212375219]
["SDC2/CD362",29.2766934557979,31.2961975158119]
[]
["p53-mediated proliferation and survival"]
["IFITM2",54.1905855338691,56.9000990627143]
["REST",30.4885827273887,31.9896365160405]
["PTEN",13.5093761959434,15.8347938733521]
["TRIM22",2.79372368924608,3.0938047702507]
["IFITM1",1.42875366755964,1.40211841804465]
["KLF4",0.701620104605179,0.96776651680256]

{"sheet":"metabolism","index":2,"n_rows":21,"n_cols":5,"rows_kept":21,"cut":false,"hidden":false,"merged":[]}
[]
[null,"TESR-E8","StemFlex",null,"Function"]
["Metabolism"]
["BRIX1",51.23102437,53.34146156,null,"ribosomal large subunit assembly"]
["GAL",49.11340732,52.01554523]
["IDO1",17.19607093,18.9743199,null,"tryptophan metabolism"]
["HESX1",11.18765149,12.81719119,null,"pituitary development"]
["SEMA3A",8.547008547,9.007086794]
[]
["SCT",1.51805077178212,1.77550864893698,null,"Regulation of body water homeostasis"]
[]
["PFKFB2",1.49253731343284,1.48594071477558,null,"Control of glycolysis"]
["FPGT",1.33945656333716,1.20399298940791,null,"Turnover of glycoproteins and glycolipids"]
["CHST13",2.06659012629162,2.34702430846605,null,"Glycosaminoglycan metabolism"]
["DOPEY1",1.73491516775099,1.65358530823745,null,"Protein trafficking between Golgi and early endosomes"]
["FICD/HYPE",2.62788620997576,2.96426122075745,null,"Refolding misfolded proteins, maintenance of the ER homeostasis"]
["ATP8A1",1.78594208444955,2.17175950621047,null,"Vesicle formation, uptake of lipid signalling molecules"]
["ZNF571",1.16086235489221,1.29543549493256,null,"Putative transcriptional regulator"]
["TMEM35A",2.34723816813369,2.37750514364094,null,"Putative role in neurite outgrowth"]
["TMEM220-AS1",2.94680443934175,3.04808351748838,null,"Long non-coding RNA, unknown function"]
["RP11-95D17.1",1.32669983416252,1.85171073687419,null,"Unknown function"]