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{"sheet":"Table S7","index":0,"n_rows":169,"n_cols":7,"rows_kept":169,"cut":false,"hidden":false,"merged":[[0,0,0,2],[0,4,0,6]]}
["Significant gradient muscle metabolites before HCD",null,null,null,"Significant gradient muscle metabolites after HCD"]
["Biochemical Name","Fold Change (log2) Evening/Morning","p-value (-log10)",null,"Biochemical Name","Fold Change (log2) Evening/Morning","p-value (-log10)"]
["3-hydroxyisobutyrate",1.7092906357233579,4.974243685465586,null,"trans-4-hydroxyproline",1.5109619192773793,9.6035565398875722]
["cytidine",-4.0588936890535683,4.4140770211583122,null,"methionine sulfoxide",0.78240856492737332,8.762581943953764]
["isovalerylcarnitine (C5)",1.9486008474933556,4.2577227448640764,null,"stearate (18:0)",0.66902676550963081,7.0751007359857168]
["2-hydroxyglutarate",0.69599381310990016,4.0903423620160817,null,"3-hydroxyisobutyrate",2.0143552929770703,6.2478132149114476]
["isobutyrylcarnitine (C4)",1.9855004303048851,4,null,"isobutyrylcarnitine (C4)",2.5631581304028082,5.6733774354843449]
["2-methylbutyrylcarnitine (C5)",1,3.2218487496163566,null,"isovalerylcarnitine (C5)",2.2750070474998698,5.3105224293732993]
["succinate",-0.45403163089470749,2.8860566476931631,null,"palmitate (16:0)",0.66902676550963081,5.1667062348322039]
["phenyllactate (PLA)",0.87970576628228825,2.744727494896694,null,"2-hydroxybutyrate/2-hydroxyisobutyrate",0.99276843076892418,4.7904581779833997]
["alpha-ketoglutarate",-0.9434164716336324,2.744727494896694,null,"cytidine",-4.3219280948873626,4.7647999230307247]
["sphingadienine",-0.6438561897747247,2.6989700043360187,null,"2-methylbutyrylcarnitine (C5)",1.2986583155645153,4.6781117224177029]
["lactosyl-N-palmitoyl-sphingosine (d18:1/16:0)",2.3276873641760472,2.6989700043360187,null,"glutamate, gamma-methyl ester",0.96347412397488608,4.5545047731710921]
["3-hydroxybutyrylcarnitine (2)",-0.78587519464715272,2.6382721639824069,null,"pipecolate",1,4.5309589436548423]
["N-methylproline",1.4276061727818994,2.4948500216800942,null,"cytidine 5'-diphosphocholine",-1.5145731728297585,4.2743741817869383]
["sphingomyelin (d18:1/18:1, d18:2/18:0)",-0.21759143507262679,2.4948500216800942,null,"1,2-dipalmitoyl-GPE (16:0/16:0)*",1.7484612330040357,4.1188436789244367]
["ceramide (d18:1/17:0, d17:1/18:0)*",-0.57776699931695219,2.4436974992327127,null,"lactosyl-N-palmitoyl-sphingosine (d18:1/16:0)",3.0652276227756192,4.0535673867655637]
["palmitoleate (16:1n7)",-0.45403163089470749,2.4089353929735009,null,"palmitoyl-docosahexaenoyl-glycerol (16:0/22:6) [2]*",1.7441610955704101,4]
["2-hydroxybutyrate/2-hydroxyisobutyrate",0.5945485495503543,2.2676062401770314,null,"orotate",1.8599695482210259,4]
["choline phosphate",-0.6438561897747247,2.2596373105057563,null,"proline",0.40053792958372886,3.6989700043360187]
["ceramide (d18:1/14:0, d16:1/16:0)*",-0.53533173299655579,2.1870866433571443,null,"dimethylglycine",0.35614381022527536,3.5228787452803374]
["cytidine 5'-diphosphocholine",-0.97143084780322919,2.1487416512809245,null,"cytidine 5'-monophospho-N-acetylneuraminic acid",0.91073266190291258,3.5228787452803374]
["myristoleate (14:1n5)",-0.37706964907982332,2.1191864077192086,null,"eicosenoate (20:1)",0.67807190511263782,3.5228787452803374]
["butyrylcarnitine (C4)",-0.66657626627480826,2.1191864077192086,null,"glycochenodeoxycholate",2.2295879227406519,3.5228787452803374]
["ceramide (d18:1/20:0, d16:1/22:0, d20:1/18:0)*",-0.39592867633113921,2.1191864077192086,null,"glucose",0.40053792958372886,3.3979400086720375]
["lignoceroylcarnitine (C24)*",-0.86249647625006509,2.0861861476162833,null,"glycocholate",1.7224660244710912,3.3979400086720375]
["glutamate",-0.49410907027004275,2.0705810742857071,null,"lactosyl-N-nervonoyl-sphingosine (d18:1/24:1)*",2.0565835283663674,3.3010299956639813]
["stachydrine",1.0703893278913981,2.0555173278498313,null,"glycylvaline",1.0496307677246004,3.2218487496163566]
["maltose",0.88752527074158749,2.0132282657337552,null,"erucate (22:1n9)",0.5360529002402098,3.2218487496163566]
["acisoga",-0.49410907027004275,2.0087739243075053,null,"docosadienoate (22:2n6)",1.1699250014423124,3.2218487496163566]
["N-stearoyl-sphingadienine (d18:2/18:0)*",-0.49410907027004275,1.9871627752948278,null,"2-hydroxyglutarate",0.5945485495503543,3.2218487496163566]
["phosphoethanolamine",-0.62148837674627011,1.9829666607012197,null,"UDP-N-acetylglucosamine/galactosamine",0.60407132366886085,3.0969100130080562]
["lactosyl-N-nervonoyl-sphingosine (d18:1/24:1)*",1.4489009511451278,1.9586073148417751,null,"palmitoyl-docosahexaenoyl-glycerol (16:0/22:6) [1]*",1.1953475983222193,3.0969100130080562]
["linoleoyl ethanolamide",-0.9434164716336324,1.9546770212133426,null,"erythronate*",0.71369581484335898,3.0457574905606752]
["ceramide (d18:2/24:1, d18:1/24:2)*",-0.39592867633113921,1.9208187539523751,null,"dihomo-linoleate (20:2n6)",0.65076455911690234,3.0457574905606752]
["N-palmitoyl-sphingadienine (d18:2/16:0)*",-0.6438561897747247,1.8961962790440432,null,"gamma-glutamyl-epsilon-lysine",1.4329594072761063,3]
["10-heptadecenoate (17:1n7)",-0.39592867633113921,1.856985199745905,null,"N-acetylmethionine",0.68706068833989242,2.9208187539523753]
["N-stearoyl-sphingosine (d18:1/18:0)*",-0.47393118833241243,1.8446639625349381,null,"1-stearoyl-2-oleoyl-GPE (18:0/18:1)",0.80735492205760406,2.9208187539523753]
["beta-citrylglutamate",-0.45403163089470749,1.8386319977650252,null,"pyrraline",1.0071955014042038,2.9208187539523753]
["glucose",0.26303440583379378,1.832682665251824,null,"phenylalanine",0.44360665147561484,2.8860566476931631]
["linolenate [alpha or gamma; (18:3n3 or 6)]",-0.53533173299655579,1.8181564120552274,null,"propionylcarnitine (C3)",0.61353165291792711,2.8538719643217618]
["glycochenodeoxycholate",1.3950627995175777,1.7878123955960423,null,"urea",0.43295940727610632,2.8239087409443187]
["3-methyl-2-oxovalerate",-0.71311885221183846,1.7825160557860937,null,"gamma-glutamylglutamine",1.0635029423061579,2.8239087409443187]
["hexanoylcarnitine (C6)",-0.88896868761125614,1.7619538968712045,null,"sedoheptulose-7-phosphate",0.73118324157220005,2.8239087409443187]
["glycocholate",1.1043366598147357,1.7235381958267559,null,"N-palmitoyl-sphinganine (d18:0/16:0)",1.7949356628035364,2.7695510786217259]
["stearoyl ethanolamide",-0.35845397091247633,1.6736641390712486,null,"sulfate*",1.7570232465074596,2.744727494896694]
["1-(1-enyl-stearoyl)-2-arachidonoyl-GPE (P-18:0/20:4)*",-0.18442457113742744,1.6655462488490691,null,"thioproline",1.2868811477881617,2.7212463990471711]
["adenosine",1.3448284969974413,1.6382721639824072,null,"indoleacetate",1.3561438102252754,2.6989700043360187]
["margarate (17:0)",-0.2515387669959645,1.5606673061697374,null,"3-hydroxybutyrate (BHBA)",1.1440463696167069,2.6989700043360187]
["oleate/vaccenate (18:1)",-0.47393118833241243,1.5331323796458904,null,"10-nonadecenoate (19:1n9)",0.65076455911690234,2.6777807052660809]
["ornithine",0.35614381022527536,1.518557371497695,null,"sphinganine",1.3895668117627258,2.6575773191777938]
["fructose",0.45417589318580209,1.4975728800155672,null,"methylphosphate",0.47508488294878265,2.6575773191777938]
["cholesterol",-0.28630418515664108,1.4934949675951279,null,"dihydroxyacetone phosphate (DHAP)",0.37851162325372983,2.6197887582883941]
["glycine",-0.26881675842780001,1.47755576649368,null,"17-methylstearate",0.66902676550963081,2.6020599913279625]
["palmitoyl ethanolamide",-0.37706964907982332,1.4509967379742121,null,"nonadecanoate (19:0)",0.38956681176272562,2.5850266520291822]
["erucate (22:1n9)",-0.30400618689009989,1.4485500020271249,null,"glycodeoxycholate",2.1276332797258739,2.5850266520291822]
["S-adenosylmethionine (SAM)",0.74846123300403555,1.4388986163509441,null,"6-phosphogluconate",1.3161457422933565,2.5686362358410126]
["palmitate (16:0)",-0.28630418515664108,1.4259687322722812,null,"C-glycosyltryptophan",0.83995958748953181,2.5528419686577806]
["trimethylamine N-oxide",-0.41503749927884381,1.4122890349810886,null,"1-palmitoyl-2-oleoyl-GPE (16:0/18:1)",0.86393845042397166,2.5086383061657274]
["1-oleoylglycerol (18:1)",-0.45403163089470749,1.391473966422806,null,"3-methylglutaconate",1.3161457422933565,2.4948500216800942]
["dihomo-linoleate (20:2n6)",-0.37706964907982332,1.3819519032879073,null,"palmitoyl dihydrosphingomyelin (d18:0/16:0)*",0.66902676550963081,2.4814860601221125]
["eicosapentaenoate (EPA; 20:5n3)",-0.47393118833241243,1.3419886033428876,null,"15-methylpalmitate",0.35614381022527536,2.3767507096020997]
["1-arachidonoyl-GPE (20:4n6)*",-0.34007544159762171,1.3372421683184259,null,"coenzyme A",-1.7369655941662063,2.3565473235138126]
["1-(1-enyl-palmitoyl)-2-arachidonoyl-GPC (P-16:0/20:4)*",-0.26881675842780001,1.3178549236261683,null,"aspartate",1.3219280948873624,2.3467874862246565]
["N6-acetyllysine",0.83995958748953181,1.3142582613977363,null,"linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*",1.2016338611696504,2.3279021420642825]
[{"$nulls":4},"N-formylmethionine",0.46466826700344421,2.2676062401770314]
[{"$nulls":4},"1-palmitoyl-2-stearoyl-GPC (16:0/18:0)",0.54596836910529256,2.2676062401770314]
[{"$nulls":4},"oleate/vaccenate (18:1)",0.61353165291792711,2.2518119729937998]
[{"$nulls":4},"3-indoxyl sulfate",1.4329594072761063,2.2006594505464183]
[{"$nulls":4},"cysteine",0.69599381310990016,2.2006594505464183]
[{"$nulls":4},"alanylleucine",1.3504972470841332,2.1870866433571443]
[{"$nulls":4},"S-allylcysteine",-1.6438561897747248,2.1674910872937638]
[{"$nulls":4},"adenine",-0.47393118833241243,2.1611509092627448]
[{"$nulls":4},"glycosyl-N-palmitoyl-sphingosine (d18:1/16:0)",2.3419857472286161,2.1549019599857431]
[{"$nulls":4},"tryptophan",0.40053792958372886,2.1487416512809245]
[{"$nulls":4},"behenoyl dihydrosphingomyelin (d18:0/22:0)*",0.71369581484335898,2.1366771398795441]
[{"$nulls":4},"dihomo-linolenate (20:3n3 or n6)",0.71369581484335898,2.1249387366082999]
[{"$nulls":4},"1-palmitoyl-2-docosahexaenoyl-GPE (16:0/22:6)*",0.77399632511117322,2.1249387366082999]
[{"$nulls":4},"maltose",0.91838623444634793,2.1135092748275182]
[{"$nulls":4},"tyrosine",0.35614381022527536,2.1023729087095586]
[{"$nulls":4},"arachidate (20:0)",0.31034012061215049,2.0915149811213505]
[{"$nulls":4},"N6-acetyllysine",1.1505596765753814,2.0861861476162833]
[{"$nulls":4},"nervonate (24:1n9)*",0.62293035092017679,2.0861861476162833]
[{"$nulls":4},"AICA ribonucleotide",0.50589092972995731,2.0809219076239263]
[{"$nulls":4},"glutathione, reduced (GSH)",0.40053792958372886,2.0705810742857071]
[{"$nulls":4},"leucylglycine",0.91838623444634793,2.0705810742857071]
[{"$nulls":4},"S-methylcysteine",0.56559717585422509,2.0655015487564321]
[{"$nulls":4},"margarate (17:0)",0.29865831556451516,2.0655015487564321]
[{"$nulls":4},"1-stearoyl-2-arachidonoyl-GPC (18:0/20:4)",0.2509615735332188,2.0655015487564321]
[{"$nulls":4},"N-acetylalanine",0.37851162325372983,2.0604807473813813]
[{"$nulls":4},"N-stearoyl-sphinganine (d18:0/18:0)*",1.5558161550616398,2.0315170514460648]
[{"$nulls":4},"heme",0.83995958748953181,2.0132282657337552]
[{"$nulls":4},"N-stearoyl-sphingosine (d18:1/18:0)*",-0.49410907027004275,1.9706162223147903]
[{"$nulls":4},"ornithine",0.42223300068304781,1.9430951486635273]
[{"$nulls":4},"tryptophan betaine",0.55581615506163962,1.9393021596463884]
[{"$nulls":4},"dehydroisoandrosterone sulfate (DHEA-S)",1.0143552929770701,1.9393021596463884]
[{"$nulls":4},"urate",0.66902676550963081,1.9393021596463884]
[{"$nulls":4},"oleoyl-linoleoyl-glycerol (18:1/18:2) [1]",0.54596836910529256,1.9355420107730816]
[{"$nulls":4},"caffeine",1.9963887464476213,1.9208187539523751]
[{"$nulls":4},"1-oleoyl-GPC (18:1)",0.75702324650745967,1.9065783148377649]
[{"$nulls":4},"myristoyl dihydrosphingomyelin (d18:0/14:0)*",0.76553474636297703,1.889410289700751]
[{"$nulls":4},"indolelactate",1.0496307677246004,1.8827287043442358]
[{"$nulls":4},"phenol sulfate",1.1243281350022019,1.853871964321762]
[{"$nulls":4},"docosapentaenoate (n6 DPA; 22:5n6)",0.98550043030488488,1.8356471442155629]
[{"$nulls":4},"S-1-pyrroline-5-carboxylate",0.50589092972995731,1.8210230527068305]
[{"$nulls":4},"cholesterol",0.32192809488736235,1.8124792791635369]
[{"$nulls":4},"2-stearoyl-GPE (18:0)*",1.1953475983222193,1.8013429130455774]
[{"$nulls":4},"fructose",0.51601514700366469,1.790484985457369]
[{"$nulls":4},"tiglylcarnitine (C5:1-DC)",0.83187724119167306,1.7878123955960423]
[{"$nulls":4},"glutamate",-0.43440282414577491,1.7695510786217261]
[{"$nulls":4},"3-(4-hydroxyphenyl)lactate",0.48542682717024171,1.7471469690201069]
[{"$nulls":4},"gluconate",0.94860084749335571,1.744727494896694]
[{"$nulls":4},"sphingomyelin (d18:1/20:1, d18:2/20:0)*",0.65992455840237829,1.7375489102695705]
[{"$nulls":4},"androstenediol (3beta,17beta) disulfate (1)",1.0635029423061579,1.7304870557820837]
[{"$nulls":4},"succinate",-0.32192809488736229,1.6946486305533763]
[{"$nulls":4},"stearoyl-arachidonoyl-glycerol (18:0/20:4) [1]*",0.56559717585422509,1.6675615400843946]
[{"$nulls":4},"1,2-dipalmitoyl-GPC (16:0/16:0)",0.38956681176272562,1.6655462488490691]
[{"$nulls":4},"creatine phosphate",0.88752527074158749,1.6345120151091004]
[{"$nulls":4},"leucine",0.26303440583379378,1.6289321377282637]
[{"$nulls":4},"stearoyl sphingomyelin (d18:1/18:0)",-0.18442457113742744,1.6234230429434879]
[{"$nulls":4},"adenosine 3',5'-cyclic monophosphate (cAMP)",-0.68965987938784945,1.6216020990518623]
[{"$nulls":4},"1-(1-enyl-stearoyl)-2-oleoyl-GPE (P-18:0/18:1)",0.51601514700366469,1.6090648928966209]
[{"$nulls":4},"oleoyl-oleoyl-glycerol (18:1/18:1) [2]*",0.58496250072115619,1.6073030467403342]
[{"$nulls":4},"10-heptadecenoate (17:1n7)",0.36737106564852945,1.5985994592184558]
[{"$nulls":4},"ceramide (d16:1/24:1, d18:1/22:1)*",0.79908730607400358,1.5951662833800619]
[{"$nulls":4},"galactonate",0.52606881166758768,1.5934598195660448]
[{"$nulls":4},"palmitoyl sphingomyelin (d18:1/16:0)",0.40053792958372886,1.585026652029182]
[{"$nulls":4},"UDP-glucuronate",0.91073266190291258,1.5816987086802545]
[{"$nulls":4},"beta-hydroxyisovalerate",0.32192809488736235,1.5622494371796121]
[{"$nulls":4},"2,3-dihydroxyisovalerate",1.0426443374084939,1.5622494371796121]
[{"$nulls":4},"ceramide (d18:1/17:0, d17:1/18:0)*",-0.41503749927884381,1.5575202309355514]
[{"$nulls":4},"3-methyl-2-oxobutyrate",0.38956681176272562,1.5512936800949202]
[{"$nulls":4},"3-hydroxy-3-methylglutarate",0.40053792958372886,1.5214335044061567]
[{"$nulls":4},"phenyllactate (PLA)",0.5945485495503543,1.518557371497695]
[{"$nulls":4},"behenate (22:0)*",0.29865831556451516,1.5142785735184201]
[{"$nulls":4},"S-adenosylhomocysteine (SAH)",0.38956681176272562,1.5114492834995557]
[{"$nulls":4},"1-palmitoyl-2-arachidonoyl-GPI (16:0/20:4)*",0.86393845042397166,1.5016894462103996]
[{"$nulls":4},"1-palmitoyl-2-linoleoyl-GPE (16:0/18:2)",0.28688114778816154,1.4921441283041692]
[{"$nulls":4},"oleoyl-linoleoyl-glycerol (18:1/18:2) [2]",0.51601514700366469,1.490797477668897]
[{"$nulls":4},"palmitoyl-oleoyl-glycerol (16:0/18:1) [2]*",0.56559717585422509,1.4788619162959638]
[{"$nulls":4},"acisoga",-0.39592867633113921,1.47755576649368]
[{"$nulls":4},"alpha-hydroxyisovalerate",0.35614381022527536,1.4710832997223453]
[{"$nulls":4},"valine",0.20163386116965043,1.4659738939438649]
[{"$nulls":4},"gamma-glutamylcysteine",1.3219280948873624,1.4634415574284698]
[{"$nulls":4},"N-stearoyl-sphingadienine (d18:2/18:0)*",-0.39592867633113921,1.4473317838878068]
[{"$nulls":4},"androsterone sulfate",1.0071955014042038,1.4436974992327127]
[{"$nulls":4},"N-palmitoyl-sphingosine (d18:1/16:0)",0.38956681176272562,1.4377071355435254]
[{"$nulls":4},"1-linoleoyl-2-arachidonoyl-GPC (18:2/20:4n6)*",0.28688114778816154,1.4341521813264824]
[{"$nulls":4},"sphingomyelin (d17:1/16:0, d18:1/15:0, d16:1/17:0)*",0.49569516262406882,1.4122890349810886]
[{"$nulls":4},"choline",0.31034012061215049,1.3968556273798178]
[{"$nulls":4},"linoleoyl-linoleoyl-glycerol (18:2/18:2) [2]*",0.82374936030827284,1.3936186348893951]
[{"$nulls":4},"oleoyl-oleoyl-glycerol (18:1/18:1) [1]*",0.90303827011291216,1.3829996588791011]
[{"$nulls":4},"1-methylhistidine",0.40053792958372886,1.3777859770337046]
[{"$nulls":4},"uridine",0.42223300068304781,1.3746875490383261]
[{"$nulls":4},"1-oleoyl-2-arachidonoyl-GPE (18:1/20:4)*",0.43295940727610632,1.3736596326249577]
[{"$nulls":4},"1-stearoyl-2-docosahexaenoyl-GPC (18:0/22:6)",0.50589092972995731,1.3695721249749762]
[{"$nulls":4},"xanthine",0.55581615506163962,1.3695721249749762]
[{"$nulls":4},"1-palmitoyl-2-arachidonoyl-GPE (16:0/20:4)*",0.27500704749986982,1.368556230986828]
[{"$nulls":4},"arabonate/xylonate",0.29865831556451516,1.3625102704874892]
[{"$nulls":4},"laurylcarnitine (C12)",0.50589092972995731,1.3615107430453628]
[{"$nulls":4},"1-methylhistamine",0.98550043030488488,1.3516399890190685]
[{"$nulls":4},"glycerate",0.29865831556451516,1.3458234581220394]
[{"$nulls":4},"ximenoylcarnitine (C26:1)*",0.34482849699744117,1.3214816209598861]
[{"$nulls":4},"palmitoyl-linoleoyl-glycerol (16:0/18:2) [2]*",0.51601514700366469,1.3187587626244128]
[{"$nulls":4},"mead acid (20:3n9)",0.66902676550963081,1.3178549236261683]
[{"$nulls":4},"5-methylthioadenosine (MTA)",0.45417589318580209,1.3151546383555874]
[{"$nulls":4},"orotidine",0.50589092972995731,1.3133637307377066]
[{"$nulls":4},"sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0)",0.22650852980867975,1.3098039199714864]
[{"$nulls":4},"S-lactoylglutathione",0.29865831556451516,1.30189945437661]