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{"sheet":"Table S9","index":0,"n_rows":117,"n_cols":7,"rows_kept":117,"cut":false,"hidden":false,"merged":[[0,0,0,2],[0,4,0,6]]}
["Significantly changed muscle metabolites by HCD in the morning",null,null,null,"Significantly changed muscle metabolites by HCD in the evening"]
["Biochemical Name","Fold Change (log2)     Post/Pre","p-value (-log10)",null,"Biochemical Name","Fold Change (log2)     Post/Pre","p-value (-log10)"]
["theobromine",-2.7369655941662061,7.4818415374133087,null,"pipecolate",1.8237493603082728,10.007472991287088]
["trimethylamine N-oxide",-1.2515387669959643,6.768097350543357,null,"N-methylproline",-2.4739311883324122,5.5076867035175034]
["1-linoleoyl-2-linolenoyl-GPC (18:2/18:3)*",-1.15200309344505,6.0473722036845139,null,"arabitol/xylitol",1.0635029423061579,5.4582460750171728]
["trans-4-hydroxyproline",-0.81096617560998319,4.1892837081647905,null,"methionine sulfoxide",0.54596836910529256,5.4561429499294087]
["2-aminobutyrate",-0.55639334852438527,4.0365569126746008,null,"trans-4-hydroxyproline",0.97085365434048343,5.3980594560793325]
["dimethylglycine",-0.35845397091247633,3.6989700043360187,null,"theobromine",-2.0588936890535687,5.1076382213663631]
["ceramide (d18:1/20:0, d16:1/22:0, d20:1/18:0)*",-0.57776699931695219,3.6989700043360187,null,"cytidine 5'-monophospho-N-acetylneuraminic acid",1.1375035237499351,4.8716007312821938]
["beta-citrylglutamate",-0.71311885221183846,3.5228787452803374,null,"dihydroxyacetone phosphate (DHAP)",0.56559717585422509,4.6537644183009625]
["1-stearoyl-2-arachidonoyl-GPC (18:0/20:4)",-0.35845397091247633,3.5228787452803374,null,"S-methylcysteine",0.92599941855622303,4.2868708192482163]
["sphingomyelin (d18:1/21:0, d17:1/22:0, d16:1/23:0)*",-0.57776699931695219,3.5228787452803374,null,"erucate (22:1n9)",0.64154602908752378,4.2653361586644278]
["sphingomyelin (d18:2/23:0, d18:1/23:1, d17:1/24:1)*",-0.6438561897747247,3.5228787452803374,null,"trimethylamine N-oxide",-0.86249647625006509,4.1394044882302863]
["tricosanoyl sphingomyelin (d18:1/23:0)*",-0.43440282414577491,3.3010299956639813,null,"arabonate/xylonate",0.63226821549951295,4.1357144309007658]
["1-linoleoyl-2-arachidonoyl-GPC (18:2/20:4n6)*",-0.49410907027004275,3.2218487496163566,null,"dihomo-linoleate (20:2n6)",0.73984810269932755,3.6989700043360187]
["1-(1-enyl-palmitoyl)-GPC (P-16:0)*",-0.6438561897747247,3.2218487496163566,null,"palmitate (16:0)",0.51601514700366469,3.5228787452803374]
["sphingomyelin (d18:1/20:0, d16:1/22:0)*",-0.51457317282975834,3.1549019599857431,null,"docosadienoate (22:2n6)",1.2265085298086797,3.3979400086720375]
["arabitol/xylitol",0.71369581484335898,3.0969100130080562,null,"stearate (18:0)",0.38956681176272562,3.3010299956639813]
["1-stearoyl-2-oleoyl-GPC (18:0/18:1)",-0.45403163089470749,3.0457574905606752,null,"eicosenoate (20:1)",0.63226821549951295,3.0969100130080562]
["behenoyl sphingomyelin (d18:1/22:0)*",-0.53533173299655579,3.0457574905606752,null,"nervonate (24:1n9)*",0.79908730607400358,3.0457574905606752]
["3-aminoisobutyrate",-0.45403163089470749,3.0457574905606752,null,"1-linoleoyl-2-linolenoyl-GPC (18:2/18:3)*",-0.71311885221183846,3]
["4-methylcatechol sulfate",1.6780719051126378,3.0457574905606752,null,"palmitoleate (16:1n7)",0.52606881166758768,2.9586073148417751]
["succinate",-0.47393118833241243,2.9586073148417751,null,"palmitoyl-docosahexaenoyl-glycerol (16:0/22:6) [1]*",1.1440463696167069,2.9208187539523753]
["betaine",-0.30400618689009989,2.9208187539523753,null,"3-methylxanthine",-0.97143084780322919,2.744727494896694]
["stearate (18:0)",-0.35845397091247633,2.8860566476931631,null,"stachydrine",-1.2863041851566412,2.6777807052660809]
["sphingomyelin (d18:1/17:0, d17:1/18:0, d19:1/16:0)",-0.37706964907982332,2.795880017344075,null,"creatine phosphate",1.2265085298086797,2.6382721639824069]
["palmitate (16:0)",-0.43440282414577491,2.7212463990471711,null,"1-linoleoylglycerol (18:2)",0.62293035092017679,2.6197887582883941]
["palmitoyl-docosahexaenoyl-glycerol (16:0/22:6) [2]*",-1.3584539709124763,2.7212463990471711,null,"10-heptadecenoate (17:1n7)",0.47508488294878265,2.3565473235138126]
["sphingomyelin (d18:0/18:0, d19:0/17:0)*",-0.76121314041288357,2.7212463990471711,null,"10-nonadecenoate (19:1n9)",0.58496250072115619,2.2757241303992108]
["1,2-dilinoleoyl-GPC (18:2/18:2)",-0.39592867633113921,2.6989700043360187,null,"adipoylcarnitine (C6-DC)",-0.86249647625006509,2.2006594505464183]
["1-(1-enyl-stearoyl)-2-arachidonoyl-GPE (P-18:0/20:4)*",-0.2515387669959645,2.6989700043360187,null,"methylsuccinate",-0.32192809488736229,2.1870866433571443]
["dihydroxyacetone phosphate (DHAP)",0.38956681176272562,2.6575773191777938,null,"oleate/vaccenate (18:1)",0.60407132366886085,2.1674910872937638]
["3-methylxanthine",-0.9434164716336324,2.6382721639824069,null,"palmitoyl-docosahexaenoyl-glycerol (16:0/22:6) [2]*",1.1505596765753814,2.1366771398795441]
["cerotoylcarnitine (C26)*",-0.55639334852438527,2.6020599913279625,null,"1-oleoyl-GPG (18:1)*",1,2.1249387366082999]
["sphingomyelin (d18:1/25:0, d19:0/24:1, d20:1/23:0, d19:1/24:0)*",-0.86249647625006509,2.5850266520291822,null,"4-methylcatechol sulfate",1.3219280948873624,2.1191864077192086]
["2-methylbutyrylcarnitine (C5)",-0.86249647625006509,2.5686362358410126,null,"benzoylcarnitine*",-0.5994620704162712,2.0915149811213505]
["17-methylstearate",-0.66657626627480826,2.5686362358410126,null,"homostachydrine*",-0.45403163089470749,2.0757207139381184]
["1-palmitoyl-2-arachidonoyl-GPC (16:0/20:4n6)",-0.23446525363702297,2.5686362358410126,null,"glutamate, gamma-methyl ester",0.55581615506163962,2.0315170514460648]
["behenoylcarnitine (C22)*",-1.0588936890535685,2.431798275933005,null,"3-methylhistidine",-1.1844245711374275,2]
["behenoyl dihydrosphingomyelin (d18:0/22:0)*",-0.78587519464715272,2.431798275933005,null,"catechol sulfate",1.2927817492278462,1.9665762445130504]
["sphingomyelin (d18:1/24:1, d18:2/24:0)*",-0.6438561897747247,2.4202164033831899,null,"palmitoleoyl-linoleoyl-glycerol (16:1/18:2) [1]*",0.73118324157220005,1.9507819773298183]
["pipecolate",0.64154602908752378,2.3372421683184261,null,"15-methylpalmitate",0.31034012061215049,1.9430951486635273]
["threonine",-0.34007544159762171,2.2596373105057563,null,"1,2-dilinoleoyl-GPC (18:2/18:2)",-0.32192809488736229,1.9172146296835499]
["lignoceroyl sphingomyelin (d18:1/24:0)",-0.57776699931695219,2.2365720064370627,null,"2'-deoxycytidine 5'-monophosphate",1.1243281350022019,1.889410289700751]
["cholesterol",-0.37706964907982332,2.2076083105017461,null,"pentadecanoate (15:0)",0.28688114778816154,1.8601209135987635]
["N-palmitoyl-sphingosine (d18:1/16:0)",-0.51457317282975834,2.1938200260161129,null,"behenate (22:0)*",0.34482849699744117,1.853871964321762]
["ceramide (d18:1/14:0, d16:1/16:0)*",-0.53533173299655579,2.1804560644581312,null,"linoleoyl ethanolamide",0.91838623444634793,1.8416375079047504]
["sphingomyelin (d18:2/18:1)*",-0.51457317282975834,2.1739251972991736,null,"docosapentaenoate (n6 DPA; 22:5n6)",0.98550043030488488,1.8386319977650252]
["ophthalmate",-0.68965987938784945,2.1674910872937638,null,"myristoleate (14:1n5)",0.34482849699744117,1.832682665251824]
["sphingomyelin (d18:2/16:0, d18:1/16:1)*",-0.66657626627480826,2.1191864077192086,null,"dihomo-linolenate (20:3n3 or n6)",0.64154602908752378,1.7958800173440752]
["sphingomyelin (d18:2/24:1, d18:1/24:2)*",-0.45403163089470749,2.0809219076239263,null,"ophthalmate",-0.5994620704162712,1.7825160557860937]
["1-(1-enyl-palmitoyl)-2-arachidonoyl-GPC (P-16:0/20:4)*",-0.37706964907982332,2.0604807473813813,null,"succinate",-0.32192809488736229,1.7495799976911059]
["sphingomyelin (d18:1/18:1, d18:2/18:0)",-0.20091269392599642,2.0604807473813813,null,"margarate (17:0)",0.26303440583379378,1.7471469690201069]
["sphingomyelin (d18:1/14:0, d16:1/16:0)*",-0.6438561897747247,2.0506099933550872,null,"piperine",1.2141248053528473,1.7399286120149251]
["sphingomyelin (d18:1/22:1, d18:2/22:0, d16:1/24:1)*",-0.43440282414577491,2.0268721464003012,null,"1-arachidonoyl-GPE (20:4n6)*",0.40053792958372886,1.7375489102695705]
["palmitoyl dihydrosphingomyelin (d18:0/16:0)*",-0.57776699931695219,2.0222763947111524,null,"2-aminobutyrate",-0.32192809488736229,1.6903698325741012]
["myristoyl dihydrosphingomyelin (d18:0/14:0)*",-0.78587519464715272,1.9913998282380825,null,"gamma-glutamyl-epsilon-lysine",0.97085365434048343,1.6695862266508092]
["hippurate",1.2630344058337937,1.9829666607012197,null,"hexadecasphingosine (d16:1)*",1.1505596765753814,1.6289321377282637]
["adipoylcarnitine (C6-DC)",-0.81096617560998319,1.9746941347352298,null,"betaine",-0.20091269392599642,1.6216020990518623]
["cytidine 5'-monophospho-N-acetylneuraminic acid",0.61353165291792711,1.9706162223147903,null,"1-palmitoyl-2-linoleoyl-GPC (16:0/18:2)",-0.15200309344504997,1.5934598195660448]
["1-stearoyl-2-oleoyl-GPE (18:0/18:1)",-0.62148837674627011,1.9586073148417751,null,"1-palmitoleoylglycerol (16:1)*",0.55581615506163962,1.5833594926617189]
["1-palmitoyl-2-stearoyl-GPC (16:0/18:0)",-0.49410907027004275,1.9430951486635273,null,"2-stearoyl-GPE (18:0)*",1.0565835283663676,1.5030703519267852]
["linolenoylcarnitine (C18:3)*",-1.0588936890535685,1.9172146296835499,null,"spermidine",0.72246602447109098,1.5003129173815961]
["3-hydroxybutyrylcarnitine (1)",-0.83650126771712052,1.8961962790440432,null,"docosahexaenoate (DHA; 22:6n3)",0.58496250072115619,1.489454989793388]
["lignoceroylcarnitine (C24)*",-0.81096617560998319,1.8961962790440432,null,"4-guanidinobutanoate",-0.43440282414577491,1.4788619162959638]
["margarate (17:0)",-0.28630418515664108,1.8664610916297826,null,"N-acetylmethionine",0.43295940727610632,1.4647058799572295]
["sphingomyelin (d17:1/16:0, d18:1/15:0, d16:1/17:0)*",-0.5994620704162712,1.853871964321762,null,"1-(1-enyl-palmitoyl)-2-linoleoyl-GPC (P-16:0/18:2)*",-0.18442457113742744,1.4190750243243806]
["methylsuccinate",-0.28630418515664108,1.8507808873446201,null,"N-acetylalanine",0.28688114778816154,1.4145392704914994]
["myristoylcarnitine (C14)",-0.57776699931695219,1.8507808873446201,null,"UDP-N-acetylglucosamine/galactosamine",0.34482849699744117,1.3798639450262424]
["catechol sulfate",1.232660756790275,1.826813731587726,null,"2-methylbutyrylcarnitine (C5)",-0.57776699931695219,1.3726341434072673]
["homostachydrine*",-0.41503749927884381,1.8239087409443189,null,"mead acid (20:3n9)",0.68706068833989242,1.3726341434072673]
["caffeine",-1.9434164716336324,1.8096683018297086,null,"adenine",-0.34007544159762171,1.3526170298853801]
["linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*",-1,1.7931741239681502,null,"linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2]*",0.83187724119167306,1.3506651412878581]
["propionylcarnitine (C3)",-0.45403163089470749,1.7520267336381934,null,"1-(1-enyl-stearoyl)-2-arachidonoyl-GPE (P-18:0/20:4)*",-0.15200309344504997,1.3496924768680636]
["nervonoylcarnitine (C24:1)*",-0.66657626627480826,1.7399286120149251,null,"adenosine 5'-diphosphate (ADP)",0.27500704749986982,1.3439017979871681]
["1-stearoyl-GPC (18:0)",-0.53533173299655579,1.7351821769904636,null,"orotate",0.91073266190291258,1.3372421683184259]
["palmitoyl sphingomyelin (d18:1/16:0)",-0.41503749927884381,1.6989700043360187,null,"3-methyl-2-oxovalerate",0.58496250072115619,1.3353580244438745]
["margaroylcarnitine*",-0.51457317282975834,1.6925039620867872,null,"linoleoyl-linoleoyl-glycerol (18:2/18:2) [2]*",0.79077203786200001,1.324221658325915]
["nonadecanoate (19:0)",-0.28630418515664108,1.6861327796308465,null,"diacylglycerol (16:1/18:2 [2], 16:0/18:3 [1])*",0.55581615506163962,1.3178549236261683]
["laurylcarnitine (C12)",-0.57776699931695219,1.6497519816658373,null,"nonadecanoate (19:0)",0.2509615735332188,1.3106911408763797]
["N-palmitoyl-sphingadienine (d18:2/16:0)*",-0.5994620704162712,1.6497519816658373,null,"arachidonate (20:4n6)",0.47508488294878265,1.3106911408763797]
["hypoxanthine",-0.53533173299655579,1.6345120151091004,null,"carnitine",-0.15200309344504997,1.3045183235098026]
["N-acetylglutamate",-0.49410907027004275,1.6090648928966209]
["1-oleoyl-2-docosahexaenoyl-GPC (18:1/22:6)*",-0.39592867633113921,1.6090648928966209]
["oleate/vaccenate (18:1)",-0.49410907027004275,1.6073030467403342]
["stearoylcarnitine (C18)",-0.47393118833241243,1.5867002359187481]
["1-palmitoyl-2-arachidonoyl-GPI (16:0/20:4)*",-0.88896868761125614,1.5559552040819238]
["decanoylcarnitine (C10)",-0.55639334852438527,1.5391021572434522]
["1-palmitoyl-2-oleoyl-GPG (16:0/18:1)",-1.3584539709124763,1.5287082889410615]
["C-glycosyltryptophan",-0.5994620704162712,1.5214335044061567]
["1-(1-enyl-stearoyl)-GPE (P-18:0)*",-0.45403163089470749,1.5199930570428493]
["1-oleoyl-2-linoleoyl-GPE (18:1/18:2)*",-0.66657626627480826,1.518557371497695]
["hypotaurine",-0.39592867633113921,1.5072396109731625]
["octanoylcarnitine (C8)",-0.62148837674627011,1.4975728800155672]
["1,2-dipalmitoyl-GPE (16:0/16:0)*",-0.88896868761125614,1.496209316942819]
["3-hydroxybutyrylcarnitine (2)",-0.53533173299655579,1.4828041020500258]
["oleoyl-oleoyl-glycerol (18:1/18:1) [1]*",-0.9434164716336324,1.47755576649368]
["1-stearoyl-2-arachidonoyl-GPI (18:0/20:4)",-0.45403163089470749,1.4698003017969179]
["1-(1-enyl-palmitoyl)-2-oleoyl-GPE (P-16:0/18:1)*",-0.32192809488736229,1.4596705252091262]
["2-hydroxybutyrate/2-hydroxyisobutyrate",-0.43440282414577491,1.4353339357479107]
["valylglycine",-0.43440282414577491,1.431798275933005]
["ceramide (d18:1/17:0, d17:1/18:0)*",-0.39592867633113921,1.4306260903849541]
["15-methylpalmitate",-0.2515387669959645,1.4236586497942072]
["hexanoylcarnitine (C6)",-0.76121314041288357,1.4236586497942072]
["sphingadienine",-0.43440282414577491,1.4213607900319276]
["myristate (14:0)",-0.23446525363702297,1.4179366370882913]
["arachidate (20:0)",-0.23446525363702297,1.4134126953282451]
["linolenate [alpha or gamma; (18:3n3 or 6)]",-0.45403163089470749,1.4056074496245732]
["palmitoyl-linoleoyl-glycerol (16:0/18:2) [2]*",-0.53533173299655579,1.3957739469155299]
["1-(1-enyl-palmitoyl)-GPE (P-16:0)*",-0.41503749927884381,1.391473966422806]
["1-(1-enyl-palmitoyl)-2-oleoyl-GPC (P-16:0/18:1)*",-0.28630418515664108,1.3872161432802645]
["oleoylcarnitine (C18:1)",-0.57776699931695219,1.3675427078152758]
["glycylleucine",-0.5994620704162712,1.3535962737769305]
["1-palmitoyl-2-alpha-linolenoyl-GPC (16:0/18:3n3)*",-0.47393118833241243,1.3535962737769305]
["2-oxoarginine*",0.29865831556451516,1.3477536589966768]
["dihomo-linolenoylcarnitine (20:3n3 or 6)*",-0.49410907027004275,1.344861565188618]
["UDP-N-acetylglucosamine/galactosamine",-0.34007544159762171,1.3372421683184259]