Gene,Number of SNV,SKAT-O p-value,Rank GLS2,18,0.002273608,1 TUBD1,10,0.00274338,2 NAA15,10,0.004585025,3 SEPT8,40,0.007117926,4 YLPM1,36,0.008439627,5 ICK,14,0.010359797,6 C14orf79,27,0.011726267,7 PSME3,10,0.012639396,8 GPRC6A,14,0.012687888,9 PGGT1B,8,0.012801809,10 CCDC108,69,0.014618952,11 GTF2H4,30,0.016783787,12 BEND5,7,0.018951119,13 DSEL,27,0.022791065,14 LOC100129175,24,0.025432168,15 SEC63,22,0.026126415,16 SLC3A2,15,0.030994139,17 C2orf80,14,0.038104867,18 SIDT1,41,0.0427112,19 MND1,11,0.045865681,20 IGSF3,43,0.047009516,21 ANKS6,53,0.060948995,22 LOC100287042,8,0.062822851,23 IFT172,47,0.06372106,24 TRMT12,14,0.065848866,25 AMOTL2,30,0.067026648,26 FAM201A,8,0.067054866,27 SPRY4,31,0.073390686,28 ST7-OT4,4,0.080318818,29 FRMD5,31,0.082623214,30 LCMT2,13,0.083775611,31 KRIT1,19,0.084330068,32 KIF19,48,0.093968225,33 FGG,8,0.094247039,34 FAM151B,10,0.109092564,35 SRSF4,13,0.111642382,36 GLI3,66,0.113718554,37 AKR1C3,19,0.11435541,38 ZNF639,10,0.115475594,39 UPB1,33,0.116875352,40 DDR1,59,0.118629472,41 TCF20,26,0.121590313,42 TATDN2,31,0.122517575,43 PAX3,34,0.12425082,44 APOA4,21,0.131669386,45 RAD54L,9,0.131920122,46 TCF7L2,29,0.134582691,47 FAM221A,18,0.136341202,48 IGSF11,27,0.138344336,49 EFCAB4B,60,0.150215064,50 CHORDC1,18,0.152049315,51 TTC16,23,0.152191808,52 LRMP,23,0.152873362,53 GP5,19,0.156845338,54 CABYR,9,0.159123971,55 SLC1A7,42,0.162247828,56 WDR3,27,0.162992242,57 ZC3HAV1,46,0.168865829,58 IQCC,10,0.169815486,59 NRDE2,37,0.17953944,60 RAD51,14,0.179912614,61 EYS,75,0.181038406,62 AHSG,19,0.186706855,63 TMEM260,26,0.198733698,64 PYROXD2,50,0.20267935,65 BAAT,13,0.205067004,66 MACC1,31,0.206895347,67 POC5,17,0.208144088,68 MGME1,11,0.210535389,69 CENPM,20,0.215941956,70 NEK3,25,0.217052696,71 PTPRF,81,0.222717738,72 NKX2-6,7,0.222996193,73 EIF3I,12,0.223896368,74 DGKI,49,0.224510317,75 EXOC3,30,0.226849,76 SEMA5A,80,0.230552037,77 FAM207A,19,0.230910658,78 CA6,34,0.231022424,79 ADM2,33,0.236023077,80 TGFB1,10,0.241139524,81 NPY6R,3,0.256002401,82 SLC9C1,19,0.257717947,83 MIR2053,1,0.259161205,84 C22orf42,23,0.259583681,85 OPRM1,35,0.26241179,86 SAYSD1,12,0.266037952,87 RBM38,21,0.266936347,88 ITGB8,23,0.277975647,89 NFYB,12,0.280473285,90 ZC3H10,4,0.283525268,91 ACKR4,5,0.285088268,92 SERPINA5,30,0.285462878,93 TYRO3,27,0.286554414,94 TTC40,175,0.292983044,95 PPEF2,28,0.293370962,96 BAG3,21,0.296884007,97 MIR4741,2,0.301939557,98 ZNF479,11,0.302614157,99 CNTN2,70,0.304673656,100 HECA,25,0.308348146,101 DPYD,40,0.309474273,102 NAP1L4,20,0.323411634,103 FNDC7,25,0.325639707,104 DST,131,0.328157185,105 SLC25A16,8,0.330108329,106 TRPM2,97,0.333275419,107 LOC101054525,4,0.336403086,108 MYRFL,26,0.339105038,109 ZNF766,31,0.339254172,110 LOC401324,7,0.342178344,111 CHRNA2,32,0.34304891,112 ANKZF1,25,0.344890151,113 MST1,17,0.345041466,114 SYNGR3,17,0.351768253,115 DEFB1,14,0.361096161,116 RASGEF1B,41,0.362162181,117 FGB,16,0.363314187,118 DPY19L4,14,0.364218305,119 FAM153B,10,0.365082907,120 FN1,66,0.365229108,121 CRISPLD2,76,0.368664966,122 WFDC10B,4,0.37842601,123 ABHD13,15,0.385665794,124 TIPRL,7,0.387798636,125 EPT1,25,0.389700906,126 ZNF460,24,0.390990112,127 OR5AK2,5,0.394494283,128 ZNF48,13,0.396347234,129 PPP1R26,39,0.396371609,130 C5AR1,13,0.396404526,131 TMEM39B,11,0.401243294,132 KLHDC4,45,0.401291047,133 E2F2,25,0.401428156,134 OSR1,6,0.407909873,135 BSDC1,20,0.408867556,136 C3orf67,22,0.409137715,137 C7orf57,24,0.411096993,138 XIRP1,26,0.416472759,139 ITFG3,50,0.417162486,140 ELAC2,41,0.419528399,141 NOMO1,20,0.420495582,142 POU5F1B,11,0.42082418,143 CEACAM20,24,0.423516901,144 PTTG2,3,0.424822551,145 TBX1,36,0.438315072,146 PHLPP1,34,0.441247537,147 TMEM81,11,0.441448287,148 AKR1E2,50,0.442019687,149 LOC100126784,7,0.444411187,150 FAT1,104,0.450267573,151 OR1F1,6,0.451079168,152 NDUFA4L2,5,0.45436378,153 PSMG3,10,0.455133275,154 TM7SF3,14,0.457332896,155 NGEF,46,0.461024872,156 ARV1,4,0.462247911,157 PDGFRA,36,0.463386316,158 FAM92A1,9,0.464425766,159 TAPT1-AS1,6,0.464918479,160 CCDC92,24,0.467928748,161 PGPEP1L,14,0.470410261,162 SMYD4,36,0.471007088,163 CDHR3,35,0.473345776,164 TICRR,44,0.47341997,165 JPH2,48,0.477850161,166 TMEM62,11,0.479806307,167 TP53BP2,28,0.489438491,168 FUBP1,10,0.492430378,169 HIVEP1,40,0.50607499,170 SPINK5,69,0.510204263,171 ZC3H12D,22,0.513150606,172 CD177,25,0.516250829,173 ABCA4,108,0.517296931,174 TNFAIP8,38,0.51842761,175 ARHGAP9,43,0.521795405,176 RUNX1,43,0.521900955,177 EHHADH,25,0.526930461,178 DOK3,37,0.527834687,179 RPS10-NUDT3,15,0.528894433,180 RPS10,12,0.530915075,181 SLIT1,63,0.531551981,182 LINC00661,7,0.531700308,183 PPP3CC,20,0.531796458,184 PDZD9,4,0.532049767,185 RSPH3,23,0.539216718,186 TEX36,6,0.542077699,187 ST5,72,0.543108475,188 COMMD2,13,0.543526165,189 C15orf60,7,0.543577638,190 SLC6A9,36,0.548781134,191 SGOL2,13,0.550133343,192 FGA,10,0.551405812,193 CES3,31,0.556260902,194 TMEM63B,38,0.561208443,195 AXDND1,40,0.562418408,196 SPRR2F,2,0.578519875,197 UGCG,20,0.578574732,198 GJA3,21,0.580075527,199 RBMXL1,16,0.580904325,200 TMEM63C,57,0.581609722,201 GABRA1,26,0.584275797,202 BRD8,39,0.585634162,203 PAK1,27,0.587089113,204 RPL29,7,0.58806976,205 TRAT1,4,0.593383597,206 MIOS,11,0.597014103,207 ZNF224,16,0.598957042,208 CTSF,16,0.599546119,209 C11orf44,23,0.600366844,210 SBF1,90,0.612165772,211 STX2,21,0.613384918,212 MRAP2,15,0.61483659,213 C7orf69,5,0.6157407,214 HTN1,4,0.618140856,215 TRIQK,12,0.618684269,216 OR13C3,3,0.623378083,217 EXPH5,43,0.623489535,218 CCDC28B,8,0.626551109,219 GPC2,15,0.630207669,220 TET1,35,0.634510094,221 ELMOD1,25,0.641013838,222 IL20RA,23,0.642096643,223 TNKS1BP1,46,0.643201086,224 BBOX1,13,0.648274935,225 CGN,23,0.64878097,226 MIR1283-1,2,0.652064729,227 SOD3,12,0.655654176,228 PDLIM5,51,0.67032826,229 DUSP3,20,0.672225711,230 SLC2A6,34,0.673695823,231 HMCN2,186,0.674346199,232 MICALL2,83,0.677221573,233 KYNU,19,0.678719753,234 TCF7,43,0.678909949,235 ABCB6,31,0.680411664,236 LOC100130691,3,0.682084158,237 TIAL1,8,0.686699748,238 CAMTA1,55,0.686705428,239 TUB,70,0.687069803,240 ROCK1,20,0.687101639,241 HCCAT5,7,0.688708954,242 ABCB11,26,0.694232767,243 SPNS3,38,0.69952451,244 SSTR3,24,0.700537618,245 PRM2,6,0.705430055,246 NR2C2,20,0.712058386,247 GNPDA1,19,0.713890868,248 C22orf24,7,0.714114039,249 KRTAP19-8,1,0.719718309,250 OR10Z1,5,0.721899212,251 USP18,29,0.722757523,252 ZNF367,12,0.729859615,253 CCDC25,16,0.730893629,254 OR13J1,3,0.731176792,255 FBXO47,9,0.731648886,256 WDR92,11,0.73380127,257 ZNRD1-AS1,18,0.736576668,258 RIPPLY2,6,0.739803557,259 AGBL2,18,0.744601346,260 FBXO10,27,0.747429458,261 KIAA0513,97,0.747899666,262 EPN3,31,0.749695069,263 EMC3,10,0.757541685,264 PPP5D1,34,0.759866795,265 FAM111B,2,0.760718825,266 C15orf56,13,0.76304254,267 CSDE1,17,0.767231922,268 FGF8,6,0.76947539,269 OR6V1,10,0.772410892,270 PCSK4,41,0.77304976,271 CHRNB4,12,0.775188678,272 CALR3,15,0.777081859,273 VANGL2,32,0.779773794,274 ALS2CL,66,0.785736512,275 CDK3,10,0.794780798,276 SDR39U1,19,0.796623599,277 ATP13A5,35,0.804174955,278 TAGAP,19,0.804812205,279 SIRT4,8,0.810881905,280 TRABD2A,12,0.814695305,281 PTPN14,34,0.814733305,282 CLDN14,19,0.819016848,283 GRAMD3,28,0.822792869,284 CCNI,11,0.823004825,285 SMCHD1,25,0.824487197,286 CDC25B,34,0.825582537,287 B2M,13,0.825968631,288 PPP2R3A,36,0.826352756,289 CD1A,19,0.827835694,290 SIPA1L3,63,0.830663892,291 PAFAH2,18,0.831728634,292 CLEC3A,18,0.833037634,293 OSER1,12,0.840087454,294 SMARCA5,22,0.84515419,295 TMEM9B,12,0.852110084,296 CCDC88B,60,0.854108052,297 SCAMP2,16,0.854575281,298 COL14A1,55,0.855781393,299 MYO1F,61,0.859104731,300 SH3TC2,44,0.862954702,301 SLC25A12,15,0.864451216,302 TCP11L1,21,0.864580613,303 PITPNM3,69,0.864741924,304 ATP4B,24,0.865290261,305 EML6,95,0.868799646,306 IGSF10,45,0.869384095,307 HDAC10,36,0.87012618,308 TXNRD1,28,0.870387906,309 KIF14,35,0.878115808,310 PLEC,208,0.882491163,311 PPP1R15B,10,0.884407081,312 PGR,55,0.884826636,313 OVCH2,41,0.884892548,314 C17orf67,27,0.886591385,315 SERTAD1,10,0.887906127,316 AGAP2,25,0.891600653,317 SCNN1A,44,0.89511632,318 QARS,13,0.896847785,319 SERPINE1,23,0.898764279,320 ELSPBP1,30,0.901846052,321 PMVK,14,0.903044289,322 ZNF229,43,0.905366282,323 DES,15,0.905705966,324 SUZ12,17,0.907509548,325 STX6,22,0.907788435,326 C16orf3,6,0.909424988,327 SEL1L2,15,0.920246301,328 PIGQ,50,0.927133624,329 BROX,11,1,330 CCNJL,34,1,330 COX6C,12,1,330 DCAF5,27,1,330 DUSP6,22,1,330 KCNH8,28,1,330 PNMAL2,20,1,330 POP4,33,1,330 PROSC,17,1,330 SPSB4,14,1,330 TRIM17,12,1,330 ZNF317,33,1,330 ZNF646,36,1,330