Gene,Number of SNV,SKAT-O p-value,Rank CCDC108,19,0.001752483,1 LOC100129175,10,0.003018812,2 GLS2,1,0.00469832,3 AMOTL2,9,0.004840928,4 C14orf79,3,0.005710999,5 GPRC6A,10,0.007326152,6 TMEM62,3,0.012171001,7 IQCC,4,0.019396975,8 PPP3CC,2,0.021054467,9 ADM2,3,0.021531452,10 POC5,7,0.02786148,11 IFT172,10,0.029536172,12 CAMTA1,10,0.030390537,13 AKR1C3,4,0.031227199,14 TCF7L2,3,0.036025505,15 BAG3,6,0.03712119,16 SPSB4,4,0.03750311,17 PDGFRA,8,0.041752652,18 FAM221A,5,0.042871563,19 DDR1,4,0.045869883,20 SIDT1,13,0.047874261,21 EYS,35,0.049007356,22 ZNF479,4,0.05360665,23 ACKR4,2,0.054319242,24 MACC1,9,0.058208493,25 DSEL,5,0.06094019,26 NOMO1,7,0.064508624,27 ANKZF1,7,0.065753282,28 FAM111B,2,0.069795344,29 QARS,3,0.0698071,30 FGG,3,0.077498658,31 EFCAB4B,10,0.081626666,32 DPYD,9,0.08202207,33 WFDC10B,1,0.086425462,34 BRD8,7,0.089791515,35 KLHDC4,9,0.089879813,36 OR13C3,2,0.094187427,37 SPRY4,3,0.098493514,38 BEND5,3,0.100463747,39 EML6,14,0.10553939,40 KIF19,16,0.107184489,41 STX2,2,0.113148028,42 PCSK4,14,0.122802686,43 TATDN2,7,0.126990047,44 COMMD2,1,0.13193127,45 C16orf3,1,0.134520202,46 PSME3,1,0.135017104,47 TMEM63C,3,0.137593107,48 PDZD9,1,0.13761808,49 ABHD13,1,0.141694232,50 SLIT1,5,0.142448793,51 TUB,4,0.147383107,52 CCNI,1,0.147437232,53 CLDN14,2,0.152589122,54 ELMOD1,2,0.157893444,55 SCNN1A,12,0.161959883,56 YLPM1,12,0.162429187,57 SH3TC2,12,0.172308958,58 AGAP2,9,0.172728847,59 TRPM2,17,0.178942073,60 ANKS6,7,0.182401026,61 EHHADH,10,0.185795147,62 WDR92,2,0.186928122,63 ZC3HAV1,8,0.188277253,64 GJA3,1,0.189019333,65 TNKS1BP1,22,0.189637087,66 SPNS3,13,0.190303119,67 RAD54L,4,0.194960044,68 SMCHD1,4,0.199196401,69 ELSPBP1,7,0.214183403,70 MYRFL,6,0.220493961,71 MST1,8,0.222504909,72 OR5AK2,5,0.232654532,73 RASGEF1B,3,0.236312248,74 C22orf24,2,0.239823176,75 SMYD4,13,0.242243912,76 OR13J1,1,0.243849717,77 LCMT2,7,0.248149021,78 OSER1,1,0.249821503,79 TNFAIP8,1,0.249981078,80 SCAMP2,4,0.251174765,81 TTC16,9,0.255585521,82 ZNF317,5,0.255693658,83 PROSC,4,0.256076463,84 SLC1A7,8,0.256852009,85 DST,64,0.258947316,86 SSTR3,6,0.260793336,87 C3orf67,5,0.26590142,88 FAT1,45,0.267883614,89 LOC100126784,1,0.270608742,90 PTPN14,6,0.275378749,91 TMEM39B,2,0.276460363,92 PPEF2,10,0.285800532,93 HIVEP1,24,0.287036679,94 WDR3,5,0.292486231,95 SEPT8,5,0.295573212,96 SUZ12,1,0.297918114,97 ABCB6,12,0.29858033,98 TMEM9B,1,0.301487326,99 BAAT,6,0.301580999,100 DEFB1,1,0.301869242,101 PTTG2,3,0.304489251,102 CENPM,3,0.305296712,103 C15orf56,6,0.312718219,104 BROX,1,0.321187574,105 TUBD1,4,0.32266526,106 SLC2A6,6,0.330882423,107 ST5,7,0.367121173,108 UGCG,1,0.36869782,109 TMEM63B,3,0.374003393,110 TRIM17,1,0.374799805,111 CSDE1,4,0.376790292,112 ZC3H12D,8,0.378685378,113 C22orf42,5,0.380408571,114 FGB,4,0.399196668,115 UPB1,2,0.407219238,116 FNDC7,10,0.407504074,117 LRMP,1,0.428367706,118 TAGAP,4,0.429852869,119 PPP1R26,17,0.43141768,120 TGFB1,4,0.433056477,121 ALS2CL,8,0.433108771,122 C17orf67,2,0.435696686,123 ZNF229,12,0.451681244,124 HTN1,1,0.461771204,125 AGBL2,4,0.462052405,126 APOA4,7,0.462725621,127 GPC2,3,0.462752027,128 NGEF,6,0.46354251,129 FRMD5,5,0.465475825,130 SERPINA5,7,0.466950395,131 PGGT1B,2,0.470509095,132 ITFG3,13,0.475226746,133 PAX3,1,0.477673898,134 ABCB11,7,0.479012395,135 SLC9C1,9,0.48154117,136 CCDC28B,2,0.492248155,137 MGME1,4,0.492544834,138 NR2C2,2,0.498104111,139 OSR1,1,0.501638727,140 BBOX1,3,0.502532916,141 ELAC2,5,0.505917691,142 ICK,2,0.508227974,143 CLEC3A,2,0.530928536,144 EXPH5,23,0.53242204,145 LOC101054525,1,0.536276,146 NRDE2,12,0.536367532,147 CABYR,5,0.537259662,148 MICALL2,18,0.53861462,149 IGSF11,3,0.539215165,150 IL20RA,5,0.542274821,151 AHSG,5,0.543830475,152 PTPRF,9,0.544509145,153 KCNH8,6,0.545719582,154 GLI3,14,0.54938444,155 KIAA0513,5,0.552193938,156 IGSF10,27,0.556438581,157 PHLPP1,14,0.556885393,158 ROCK1,4,0.557253192,159 VANGL2,7,0.557981555,160 SIRT4,3,0.562930791,161 SBF1,14,0.563618961,162 CGN,12,0.564205741,163 NAP1L4,1,0.571549374,164 NAA15,1,0.572723829,165 DPY19L4,1,0.577357601,166 C2orf80,1,0.577735692,167 KIF14,12,0.578244597,168 TCF20,8,0.578885494,169 PITPNM3,6,0.580345383,170 TYRO3,4,0.583022522,171 NEK3,6,0.583232704,172 SRSF4,5,0.584425188,173 CDHR3,10,0.589949829,174 PPP5D1,7,0.595924261,175 SGOL2,4,0.601497114,176 ZNF48,3,0.603104847,177 ZNF460,3,0.604122302,178 DGKI,4,0.604450642,179 C15orf60,2,0.607899149,180 TRABD2A,6,0.614414,181 KRIT1,3,0.618705834,182 GABRA1,1,0.623277947,183 CHRNB4,8,0.624725423,184 ITGB8,3,0.629077818,185 CTSF,4,0.629431956,186 SEL1L2,3,0.634437534,187 ZNF639,1,0.635801141,188 C7orf57,7,0.637097498,189 PGPEP1L,6,0.6373544,190 GNPDA1,1,0.641584471,191 FAM207A,3,0.642240814,192 FAM153B,4,0.644944067,193 SOD3,5,0.646257063,194 GRAMD3,2,0.649084066,195 SPINK5,15,0.649543177,196 AXDND1,3,0.653187801,197 OPRM1,8,0.657136611,198 CES3,6,0.657432596,199 CD177,10,0.659392795,200 FBXO10,4,0.661016241,201 PGR,10,0.661904215,202 MYO1F,4,0.662273481,203 RBM38,2,0.667607957,204 FGF8,1,0.671676645,205 SEC63,1,0.673476015,206 E2F2,6,0.674938461,207 GP5,3,0.678670762,208 CRISPLD2,7,0.680733584,209 FAM151B,2,0.680869335,210 SDR39U1,7,0.681201513,211 C5AR1,3,0.684814993,212 JPH2,3,0.685703472,213 POP4,3,0.690634557,214 OR10Z1,4,0.695739317,215 HDAC10,11,0.700708315,216 CALR3,1,0.702014077,217 RSPH3,6,0.708331515,218 IGSF3,12,0.713854858,219 CCDC88B,21,0.717886,220 ZNF224,10,0.718960581,221 TET1,15,0.723639223,222 TM7SF3,3,0.724122552,223 PNMAL2,5,0.724141541,224 DCAF5,5,0.729839559,225 MIOS,1,0.730043323,226 POU5F1B,2,0.730348025,227 DUSP6,3,0.743105425,228 ZNF766,6,0.747245849,229 TXNRD1,4,0.748478829,230 FBXO47,2,0.749775734,231 CEACAM20,9,0.750992655,232 USP18,3,0.76484819,233 RBMXL1,3,0.765477278,234 OR1F1,4,0.767770152,235 FGA,4,0.770765062,236 TEX36,4,0.770828964,237 TRMT12,4,0.781353537,238 PLEC,74,0.785505841,239 EPN3,14,0.792413376,240 PAFAH2,2,0.802185849,241 FN1,15,0.80342374,242 PDLIM5,9,0.804256928,243 SMARCA5,1,0.80922693,244 RUNX1,2,0.811425504,245 DES,3,0.811732758,246 COL14A1,13,0.814937062,247 SYNGR3,2,0.815996881,248 PPP2R3A,16,0.823076845,249 TICRR,17,0.823935181,250 ARV1,1,0.834053722,251 COX6C,1,0.835880773,252 OVCH2,12,0.83917229,253 SERPINE1,3,0.844691592,254 NKX2-6,4,0.849638871,255 TP53BP2,9,0.850401707,256 ARHGAP9,11,0.851635393,257 PMVK,3,0.855360337,258 ATP13A5,16,0.856045245,259 ZC3H10,2,0.857207281,260 SEMA5A,5,0.857444649,261 OR6V1,6,0.858008047,262 CNTN2,11,0.864808532,263 CCNJL,5,0.865890018,264 KYNU,3,0.866646597,265 MRAP2,2,0.86799792,266 TMEM81,3,0.868976407,267 CHRNA2,5,0.870004372,268 EXOC3,2,0.870388226,269 TRAT1,2,0.870524013,270 PYROXD2,4,0.871166841,271 TCF7,4,0.872045538,272 DOK3,12,0.873065064,273 BSDC1,3,0.873414219,274 PSMG3,2,0.877899458,275 CDK3,3,0.888579863,276 SERTAD1,3,0.889624804,277 SPRR2F,2,0.89048496,278 FAM92A1,2,0.894016947,279 TTC40,49,0.895096168,280 SIPA1L3,14,0.903121302,281 CDC25B,2,0.908197124,282 ATP4B,6,0.908440775,283 ABCA4,29,0.911407636,284 AKR1E2,4,1,285 CA6,4,1,285 CCDC92,1,1,285 CD1A,4,1,285 GTF2H4,4,1,285 HMCN2,53,1,285 PIGQ,11,1,285 PPP1R15B,3,1,285 SLC25A12,2,1,285 SLC3A2,2,1,285 TBX1,5,1,285 TCP11L1,7,1,285 TMEM260,3,1,285 XIRP1,18,1,285 ZNF646,19,1,285