This PDF file includes:

• Fig. S1. Rheological analysis of poly-Oxime and sham gels.
• Fig. S2. Ex vivo Franz diffusion assay with commercial organophosphates.
• Fig. S3. Limiting MPT-induced AChE inhibition in blood using poly-Oxime and poly-methoxyOxime.
• Fig. S4. Change in body weight and body temperature following acute exposure.
• Fig. S5. Brain AChE and body weight decrease in repeated exposure of MPT with daily application of poly-Oxime gel.
• Fig. S6. Brain AChE and body weight decrease in repeated exposure of MPT with single application of gel.
• Fig. S7. Ex vivo Franz diffusion assay with various barrier creams to measure AChE inhibition.
• Fig. S8. Ex vivo Franz diffusion assay with poly-Oxime gel before and after exposure to UV light.
• Table S1. Pseudo–first-order rate constants for hydrolysis of organophosphates by poly-Oxime polymer.
• Supplementary Methods

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