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["Supplemental Table S2: Exon-level Information in Category 2 Genes. "]
["Gene","Curated Clinically Relevant Transcript","Clinically relevant exons","Exons of uncertain significance","Clinically insignificant exons","Noncoding Exons","Common LoF in clinically insignificant or uncertain exons (c. and p.)","Allele frequency","Subpopulation","# of  variants in uncertain or insignificant exons","GTEx of coding uncertain exons","Is the longest transcript expressed in the inner ear?","Is Curated Clinically Relevant  Transcript the longest transcript?","References"]
["ACTG1","NM_001199954.1","2-6",null,null,"1","in 3'UTR 1.7%",{"$nulls":4},"unknown","Yes"]
["BCS1L","NM_004328.4","3-9",null,null,"1-2","in 5'UTR 2.6%",{"$nulls":4},"unknown","Yes"]
["CATSPER2","NM_001282310.1","1-13",{"$nulls":8},"unknown","Yes"]
["CCDC50","NM_178335.2","1-5, 7-12",6,null,null,"Many",null,null,"8B, 2LB, 4VUS, 2 DM","Exon 6 spliced out in all tissues","Yes (murine)","Yes","[15]"]
["CEP78","NM_001098802.1","3-15","1,2, 16",null,null,"Many in exons 1 and 2, Exon 16: c.1849-1G>C","Exon 16: 0.29% (2 homozygotes), 0.3%","Europeans, Ashkenazi Jews",null,"Low expression of all exons. Exons 1, 2, and 16 are not spliced out.","unknown (human retina)","Yes","[16]"]
["CHD7","NM_017780.3","2-38",null,null,"1",{"$nulls":5},"unknown","Yes"]
["COCH","NM_001347720.1","1-11",{"$nulls":8},"Yes (human fetal cochlea)","Yes","[17,18]"]
["COL11A2","NM_080680.2","1-66","2,4,45,47,59,61",{"$nulls":5},"Exon 2: 1LB, 1VUS, 2P, 1DM; Exon 4: 4VUS, 1DM; Exon 45: 1LB, 2VUS, 3DM; Exon 59: 1LB, 1VUS, 1P, 3DM; Exon 61: 1DM","All uncertain exons expressed and none are spliced out","unknown","Yes"]
["COL4A5","NM_033380.2","1-53",{"$nulls":8},"unknown","Yes"]
["DFNA5","NM_004403.2","3-10","2,6",null,"1","Exon 2: c.119_120insA (p.Lys41Glufs); Exon 6:c.712C>T (p.Arg238X)","Exon 2:3.1%; Exon 6:0.4%","Exon 2:Ashkenazi Jewish; Exon 6:Finnish European","Exon 2:1B, 2VUS, Exon 6:1LB, 6VUS","Although Exon 2 is expressed, it can be spliced out. Exon 6 is expressed and not spliced out.","unknown","Yes","Expression in mouse cochlea, but protein is only 72% identical and lacks first exon [19]"]
["DFNB59 (PJVK)","NM_001042702.3","2-7",null,null,"1",{"$nulls":5},"Yes (murine)","Yes","[20]"]
["DIABLO","NM_019887.5","2-7",null,null,"1",{"$nulls":5},"Unknown","Yes","Human cochlear expression, but nothing transcript-specific [21]"]
["EDN3","NM_207034.2","1-5",4,null,null,"c.559_560insA (p.Thr189Asnfs)","0.6% (2 homozygotes)","Finnish Europeans","2LB, 2VUS, 2DM","Exon 4 is expressed in tissues, but also predicted to be spliced out","unknown","Yes"]
["GJB6","NM_001110219.2","5",null,null,"1-4",{"$nulls":5},"unknown","Yes","all transcripts encode the same protein) [22]"]
["GPSM2","NM_013296.4","2-15",null,null,"1",{"$nulls":5},"unknown","No"]
["HARS","NM_002109.5","1-13",{"$nulls":8},"unknown","Yes"]
["HARS2","NM_012208.2","1-13",{"$nulls":8},"unknown","Yes"]
["ILDR1","NM_001199799.1","1-5, 7-8",6,null,null,"c.772C>T (p.Gln258X)",6.0000000000000001E-3,"East Asian","1B, 1LB, 1VUS, 1DM","Expression of all exons is low, including 6. 6 is predicted to be spliced out.","Yes (murine)","Yes","[23]"]
["KARS","NM_001130089.1","3-14","2, 15",null,"1","Many in Exon 15",null,null,"Exon 1 (noncoding): 4VUS, 1LP;  Exon 2: 1VUS, 1DM; Exon 15: 1B, 2VUS, 1DM","Exons 2 and 15 are expressed across tissues. While exon 15 is not alternately spliced, exon 2 is predicted to be spliced out in some transcripts.","Yes (murine, zebrafish, chicken)","Yes","[24]"]
["KCNE1","NM_000219.5","4",null,null,"1-3",{"$nulls":5},"unknown","Yes"]
["KCNQ4","NM_004700.3","1-8, 10-14",9,{"$nulls":6},"Exon 9 is expressed and largely included.","Yes (murine)","Yes","[25,26] "]
["KITLG","NM_000899.4","1-5, 7-9",6,null,"10",{"$nulls":4},"Exon 6 largely expressed in spliced in.","Yes (murine)","Yes","[27]"]
["MARVELD2","NM_001038603.2","2,4-7",3,null,"1",null,null,null,"Exon 3: 1DM","Exon 3 is expressed and can be spliced out (but inclusion is much stronger)","Yes (murine)","Yes","[28]"]
["MYH14","NM_001145809.1","2-16, 18-43",17,null,"1",null,null,null,"Exon 17: 1B, 2LB, 4DM","Exon 17 is lowly expressed and largely spliced out","unknown","Yes"]
["MYO6","NM_001300899.1","2-33",null,null,"1",{"$nulls":5},"No (absent from fetal cochlea)","No","[29]"]
["NLRP3","NM_004895.4","1-3, 5, 7-10","4,6",{"$nulls":5},"Exon 4: 5LB, 3VUS, 5DM, Exon 6: 4VUS, 2DM","Expression of all exons is low, including 4 and 6. Both are not spliced out.","unknown","Yes"]
["PRPS1","NM_002764.3","1-7",{"$nulls":8},"unknown","Yes"]
["SLC52A2","NM_024531.4","2-5",null,null,"1",{"$nulls":5},"unknown","Yes"]
["SYNE4","NM_001039876.2","1,2,4-8",3,{"$nulls":5},"1B, 1LB, 1VUS","Expression of all exons is low, but exon 3 is predicted to be spliced out","unknown","Yes"]
["TBC1D24","NM_020705.2","2-7",null,null,"1",null,null,null,"26 LP/P variants in Exon 2 suggest that it is clinically relevant.",null,"Yes (murine)","No","[30]"]
["USH1G","NM_173477.4","2-3",null,null,"1",null,null,null,"Exon 1 (noncoding): 3LP/P, 7DM",null,"unknown"]
["USH2A","NM_206933.2","2-72",null,null,"1",{"$nulls":5},"Not in murine inner ear","No, although both transcripts need to be evaluated for that reason.","[31]"]
[null,"NM_007123.5","2-21 (unique exon is slightly longer 21A)",null,null,"1"]
["WFS1","NM_006005.3","2-8",null,null,"1",{"$nulls":5},"unknown","Yes"]
[]
["Exons in the 33 Category 2 genes were divided into the three exon categories as defined in Figure 1C. Common LoF are variants pulled from gnomAD. B, LB, VUS, LP, and P variants were pulled from ClinVar. DM variants were pulled from HGMD. LoF, Loss of Function; B, Benign; VUS, Variant of uncertain significance; LP, likely pathogenic; P, Pathogenic; DM, Disease Mutation. Transcript numbers were taken from RefSeq Gene (https://www.ncbi.nlm.nih.gov/refseq/rsg/)."]