{"text_format":"2","workbook":"xlsx","n_sheets":5,"sheets":["Table S1","Table S2","Table S3","Table S4","Table S5"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":5,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"Table S1","index":0,"n_rows":49,"n_cols":16,"rows_kept":49,"cut":false,"hidden":false,"merged":[[1,12,1,14],[2,2,2,4],[2,5,2,7],[2,8,2,10]]}
["Table S1. DAG and ceramide concentrations in the fetal liver"]
[{"$nulls":12},"P-value"]
["Name","Category","CON",null,null,"OB-WSD",null,null,"OB-DR",null,null,"ANOVA","CON vs OB-WSD","OB-WSD vs OB-DR","CON vs OB-DR","VIP Rank"]
["total DAGs",null,1330.20402975663,"±",186.06603259875001,1444.4980670090399,"±",48.440272822132499,1315.46316755921,"±",103.250851150595,0.73619451046893003,0.53331302926382596,0.48285919358056201,0.93543386595786304]
["total 1,2-DAGs",null,1057.0609999999999,"±",134.66,1132.0899999999999,"±",31.57,1023.37,"±",71.41,0.68899999999999995,0.56589229268948604,0.40909331476970301,0.795499636439435]
["total 1,3-DAGs",null,273.14,"±",59.64,312.39999999999998,"±",38.590000000000003,292.08,"±",38.28,0.83899999999999997,0.56237163060739903,0.76311375662744896,0.77865315034347204]
["total dhCER",null,84.428864627259799,"±",15.624322669960801,106.593095976771,"±",10.369432625256101,79.541081988482304,"±",5.0193818168629498,0.23195758330852301,0.187311459775206,0.11359081451911,0.76308427397747802]
["total CERs",null,302.02,"±",16.77,385.73,"±",48.82,381.28,"±",15.08,0.14499999999999999,0.08,0.92100000000000004,9.6000000000000002E-2]
["Individual Species"]
["C14:0/C16:0","1,2-DAG",14.825164942516,"±",0.31349147566268898,24.03331,"±",4.5801059999999998,14.82522,"±",2.2180270000000002,7.3919281173125601E-2,4.7117322789412198E-2,4.7118397702485097E-2,0.99999007527575301,11]
["C14:0/C16:1","1,2-DAG",1.58866445251865,"±",0.174088112576334,2.7671480000000002,"±",0.80310700000000002,1.357467,"±",0.3871,0.16789655523066099,0.13805979060776899,8.1631153911775306E-2,0.76060146474249501,12]
["C14:0/C18:1","1,2-DAG",5.52987518641494,"±",0.88235770327859098,8.8788660000000004,"±",1.0923750000000001,5.5474680000000003,"±",1.0885450000000001,6.2109854843120101E-2,3.9580440692862102E-2,4.0459087396348299E-2,0.99052349135102202,7]
["C16:0/C16:1","1,2-DAG",31.796174413550499,"±",3.19509586883165,41.3324,"±",3.7554699999999999,30.495560000000001,"±",3.345818,9.0281268877663898E-2,7.3626069216832193E-2,4.58268046646522E-2,0.79375870424704198]
["C16:0/C18:0","1,2-DAG",18.9530120254068,"±",2.1078260265748101,21.177769999999999,"±",1.617014,18.937919999999998,"±",1.4933799999999999,0.59816051030728201,0.38886541866028801,0.38575673203630101,0.99525957629291695]
["C16:0/C18:1","1,2-DAG",131.574859688825,"±",15.9203209722537,191.31809999999999,"±",8.0428099999999993,142.845,"±",10.835319999999999,9.9353489994074094E-3,4.3334077024623097E-3,1.4768720401997599E-2,0.52086033152552902,14]
["C16:0/C18:2","1,2-DAG",285.97724500712098,"±",40.0368268253374,259.56450000000001,"±",5.8680770000000004,239.5633,"±",20.728549999999998,0.47751869517305301,0.490366927541176,0.59988038157678003,0.23501857734164]
["C16:0/C20:3","1,2-DAG",12.994265627571,"±",3.5776520638630802,5.6927339999999997,"±",1.056603,7.7241369999999998,"±",0.67348799999999998,8.9864892094902005E-2,3.61135573676723E-2,0.52400064013125003,0.114357070275935,3]
["C16:0/C20:4","1,2-DAG",63.536676274669396,"±",12.456127775317301,44.250219999999999,"±",5.4335009999999997,49.551070000000003,"±",6.1622870000000001,0.29892561560687603,0.139403285263521,0.67122018634145098,0.27336935407722601]
["C18:0/C16:1","1,2-DAG",3.0413896727652401,"±",0.56914244644843903,2.938974,"±",0.65303599999999995,3.2997830000000001,"±",0.50107800000000002,0.90241124538895301,0.90232799668330899,0.666647009500831,0.75725708300633898]
["C18:0/C18:1","1,2-DAG",12.506513277146,"±",1.16262139963872,22.288959999999999,"±",2.0885220000000002,15.735060000000001,"±",1.5773550000000001,3.9547366658937797E-3,1.26853168608124E-3,1.5960658371943302E-2,0.19254368641386699,5]
["C18:0/C18:2","1,2-DAG",41.657847426304997,"±",6.8638328529194403,24.79457,"±",2.4216389999999999,35.802630000000001,"±",2.6711010000000002,5.74721534859702E-2,2.06441313507452E-2,0.1076130867719,0.373227252566806,9]
["C18:0/C20:4","1,2-DAG",312.05433753909398,"±",42.977027413361498,313.76369999999997,"±",17.199159999999999,332.27760000000001,"±",23.55508,0.87086566945983002,0.96851075330477998,0.67017933671009999,0.64202025866924695]
["C18:1/C18:2","1,2-DAG",7.7312350548298499,"±",1.4698249150606599,9.2226929999999996,"±",1.1969339999999999,8.6901829999999993,"±",0.72916400000000003,0.66915482644436997,0.38612502039359903,0.75363816565282105,0.57376314052507804]
["di-C14:0","1,2-DAG",0.29766984250624601,"±",8.0709975302648299E-2,0.40812500000000002,"±",0.13600000000000001,0.31616499999999997,"±",0.133102,0.78596890012371901,0.52516163153936402,0.59582299375755599,0.91454834303482202]
["di-C16:0","1,2-DAG",61.058811511004699,"±",5.7053233912540202,76.316410000000005,"±",2.723716,57.781759999999998,"±",2.8147880000000001,1.46538868139555E-2,1.9301602081690201E-2,6.5780026051431E-3,0.57267254124865996]
["di-C16:1","1,2-DAG",0.99109242082809801,"±",4.6042078401994098E-2,1.6412549999999999,"±",0.35380400000000001,1.071043,"±",0.30237999999999998,0.219688656978723,0.114381393050592,0.161196932527328,0.83767258144981904,13]
["di-C18:0","1,2-DAG",1.8949808928929499,"±",0.19600799499879901,2.369472,"±",0.32092199999999999,1.6155919999999999,"±",0.33118199999999998,0.21776023849151299,0.268712678564893,9.0217986241357406E-2,0.50765765516952499]
["di-C18:1","1,2-DAG",26.011564222890399,"±",5.3633487158414601,63.814219999999999,"±",8.8277909999999995,38.242190000000001,"±",5.2571019999999997,5.4337914125917198E-3,1.7787812020316799E-3,1.9230342033628799E-2,0.220544366949983,2]
["di-C18:2","1,2-DAG",23.039570012148001,"±",3.2240380688886301,15.5237,"±",0.74840700000000004,17.699269999999999,"±",1.084138,5.6041438325047301E-2,2.1454750350521402E-2,0.45902334404336498,8.4897928867366204E-2]
["C16:0/C18:0","1,3-DAG",9.7887262669468402,"±",2.6280615462852301,12.878740000000001,"±",3.5985480000000001,13.91921,"±",1.7549079999999999,0.56259273703681101,0.44473605846730502,0.79469174083313698,0.31163272882076598]
["C16:0/C20:4","1,3-DAG",55.2316673916011,"±",14.063672576679201,43.015369999999997,"±",4.377656,40.906680000000001,"±",6.5008150000000002,0.51935678606383795,0.37104822470791199,0.875226319025045,0.297238125594044]
["C18:0/C20:4","1,3-DAG",158.52668509191199,"±",42.963699096138903,142.6079,"±",23.933720000000001,179.9982,"±",24.2974,0.71096384971097704,0.728444892260523,0.42013285591466099,0.64027664619048097]
["di-C16:0","1,3-DAG",19.957839369290902,"±",2.6212320840141201,25.510090000000002,"±",10.02561,17.71773,"±",4.1247670000000003,0.68653441284956596,0.55343682542448802,0.408938289766348,0.80985088140290395]
["di-C18:0","1,3-DAG",17.1719046727845,"±",3.0860493919711098,27.225210000000001,"±",3.7593619999999999,17.591259999999998,"±",3.3921230000000002,0.103290656187291,6.00041370547649E-2,6.9895256288529703E-2,0.93240724303902101,8]
["di-C18:1","1,3-DAG",12.4662574730906,"±",3.07253102304646,61.163649999999997,"±",7.6326320000000001,21.95166,"±",3.625162,5.5357584779828902E-5,2.4175428629608899E-5,1.7605986698104501E-4,0.220657944906713,1]
["C14:0","Ceramide",0.20805273852783099,"±",0.20805273852783099,0.15345127315771501,"±",0.10209561830356299,0.145661670761974,"±",8.7715512831110398E-2,0.94534646993257998,0.79184567899476099,0.96992186531434299,0.76308855432908496]
["C16:0","Ceramide",63.941677876103803,"±",6.1933054184807501,76.641781055691098,"±",9.5986379289907209,64.293227513704593,"±",1.5884423391890801,0.34054511733318399,0.20234688345603699,0.214282415056192,0.97083399593480402]
["C18:0","Ceramide",16.235020895149098,"±",2.6444122201718701,21.284224067593499,"±",3.7275474201190102,17.973972772334701,"±",0.41898055175749699,0.41864111939897602,0.202731496815795,0.39438638060386999,0.65091162865123098]
["C20:0","Ceramide",5.61391885607188,"±",1.1473097986471701,7.3455242921358499,"±",0.52741399243245701,5.9598085294153798,"±",0.36621949895003802,0.27127233410456397,0.13270642447259701,0.22107438911066901,0.75283954286654398,15]
["C22:0","Ceramide",51.1092251701075,"±",4.4182628716286798,61.736484587780097,"±",5.9881037181688104,59.622070412536097,"±",4.1036139364905901,0.30462021182677002,0.15155065121251601,0.76579343180319503,0.24339992167892399]
["C24:0","Ceramide",111.00088187207901,"±",4.9627845327807103,116.333017428358,"±",16.6763851153381,129.60764600230999,"±",3.81958677819881,0.44456075297375902,0.72029655406235005,0.379381553429739,0.224979747331465]
["C24:1","Ceramide",53.906954002987,"±",3.0827376104544499,102.236158304417,"±",17.938561247294299,103.686000077247,"±",7.4944317405973004,1.40492095033716E-2,1.09226202111284E-2,0.92960904590882298,9.2368838560588293E-3,4]
["dh-C16:0","Dihydroceramide",7.6088693296018404,"±",0.87897110653640398,9.0568732287310496,"±",0.86593883982661102,6.8118026161735301,"±",0.63198850936904505,0.17505588501422101,0.22499169334970201,7.0678460377403898E-2,0.49476274733463599]
["dh-C18:0","Dihydroceramide",10.494947530310901,"±",1.03266438168673,16.9411546604356,"±",2.8829693143897699,14.598597505934,"±",1.88566681796942,0.126397713552273,4.85463495662357E-2,0.44050798053172002,0.187561527605794,10]
["dh-C24:0","Dihydroceramide",45.447537345088499,"±",10.373150227856801,46.949077232501502,"±",7.5191056575304698,31.7174275346968,"±",2.04291357595429,0.31970800174002401,0.88962919782857197,0.17602083512939601,0.21929196609531901]
["dh-C24:1","Dihydroceramide",20.877510422258599,"±",4.3969268283830001,33.6459908551032,"±",3.2973172952164198,26.4132543316781,"±",1.6656822576071599,5.5002799567638198E-2,1.8501872051810302E-2,0.14890144079861101,0.26063933808923501,6]
["Normalized to protein (ng/mg protein in liver). Data represented as mean ± SEM. ANOVA with fixed effect for maternal diet. P < 0.05 by Student's t-test."]
["VIP rank from PLS-DA with DAGs and ceramides."]
["CER, ceramide; DAG, diacylglyceride; dh, dihydro; PLS-DA, partial least squares discriminant analysis; VIP, variable importance in projection."]

{"sheet":"Table S2","index":1,"n_rows":172,"n_cols":19,"rows_kept":172,"cut":false,"hidden":false,"merged":[[2,4,2,6],[2,7,2,9],[2,10,2,12],[1,14,1,16],[170,0,170,12]]}
["Table S2. Metabolite concentrations in the fetal liver"]
[{"$nulls":14},"P-value"]
["Metabolite","Compound ID","KEGG ID","Pathway","CON",null,null,"OB-WSD",null,null,"OB-DR",null,null,"ANOVA","CON vs OB-WSD","OB-WSD vs OB-DR","CON vs OB-DR","VIP Rank","Pathway"]
["L-Alanine","HMDB0000161","C00041","Amino acids",107727286,"±",5989960.9765920797,133980402,"±",17027601.7787099,125138500,"±",2853351.6681264499,0.24157942237563201,0.103944762187371,0.56446503973639095,0.26592331960569598]
["L-Arginine","HMDB0000517","C00062","Amino acids",778847.96,"±",114716.666852949,912652.12,"±",167329.71783923599,568376.93999999994,"±",62442.086247214698,0.177248012997233,0.45503841622857799,7.0312508652792705E-2,0.24796349058645201]
["L-Asparagine","HMDB0000168","C00152","Amino acids",8952279.1999999993,"±",837004.10257366102,9835905.5999999996,"±",549629.72902333096,9384037.4000000004,"±",152416.83585896899,0.57963395631174897,0.30633200989197601,0.59480947789502103,0.61111920522368901]
["L-Aspartic acid","HMDB0000191","C00049","Amino acids",30558494,"±",5620239.1777339904,33465336,"±",2346580.08454559,34243238,"±",3077633.4346286301,0.78802690772015205,0.61136122000909399,0.89127834036723397,0.52089360524456196]
["L-Cysteine","HMDB0000574","C00097","Amino acids",32958588.199999999,"±",9437586.0012907591,26513274,"±",3738484.3683632002,28043524,"±",3773619.7322737798,0.75331104941517102,0.48004605253857202,0.86549179416699695,0.58853005433776695]
["L-Glutamic acid","HMDB0000148","C00025","Amino acids",178931700,"±",12852969.104335399,188709580,"±",23463233.902158499,173415780,"±",10595503.7035244,0.80774429335396303,0.68462675861963296,0.52734566682074802,0.81834162684226697]
["L-Glutamine","HMDB0000641","C00064","Amino acids",204645220,"±",8809780.6877583507,237615040,"±",18875194.8787979,272558380,"±",9369923.5041914806,1.1480007970575599E-2,0.102468590785359,8.5516638099265602E-2,3.3778834792111299E-3]
["Glycine","HMDB0000123","C00037","Amino acids",43542040,"±",4056884.4613077198,41225452,"±",884761.20585387305,42710788,"±",1418774.0352938499,0.80989542338199805,0.53006612032669997,0.68576374425807796,0.82043530237182305]
["L-Histidine","HMDB0000177","C00135","Amino acids",17475170,"±",1655933.85966348,21660776,"±",3829099.3687557899,20515052,"±",1238702.5710088799,0.49716469918120099,0.26164507010752303,0.75266565402285401,0.409021341756938]
["L-Leucine","HMDB0000687","C00123","Amino acids",111755606,"±",7831962.3348070299,125714372,"±",18458349.994183801,129288640,"±",10048762.967579599,0.61185612695636804,0.460632216166596,0.84851726926131998,0.35724320496724199]
["L-Lysine","HMDB0000182","C00047","Amino acids",17750122,"±",1363408.1014076499,26997268,"±",3345926.01949505,19302064,"±",482272.77962373098,1.9786572535812001E-2,9.070812441948E-3,2.3851502191434799E-2,0.61154203342621305,12,"Yes"]
["L-Methionine","HMDB0000696","C00073","Amino acids",8223585.4000000004,"±",713752.76778332703,10364746,"±",929953.74325156596,7394573.7999999998,"±",622220.34187965898,4.6636688785511901E-2,7.1615832213424893E-2,1.7900819703203001E-2,0.45903863080982199]
["L-Phenylalanine","HMDB0000159","C00079","Amino acids",9423682.8000000007,"±",401622.61833908199,12362146,"±",767320.33178849099,11913108,"±",443870.53668158699,6.3676156412023604E-3,3.0468616098870802E-3,0.582412380531383,8.6451968505926596E-3,null,"Yes"]
["L-Proline","HMDB0000162","C00148","Amino acids",187884004,"±",30008342.744747099,327552820,"±",70167969.706115901,195364340,"±",20955484.179340702,9.0366759880062306E-2,5.1576288060850503E-2,6.3350698575417197E-2,0.90975511922221897,null,"Yes"]
["L-Serine","HMDB0000187","C00065","Amino acids",38955708,"±",3400196.5416684402,39813824,"±",2643152.79695783,43893130,"±",1101157.12423341,0.37787849507400501,0.81708901189925598,0.2830264900351,0.19872506574764301]
["L-Threonine","HMDB0000167","C00188","Amino acids",34118102,"±",4499225.4559984002,34323134,"±",3901084.3731193501,37065148,"±",2775610.2187652402,0.83086395571942595,0.97014019292752096,0.61852102015493704,0.59282878097418001]
["L-Tryptophan","HMDB0000929","C00078","Amino acids",1932940,"±",192352.43686707001,1998530,"±",150060.98713756399,1685779.4,"±",92632.350973944296,0.33537598184935202,0.763487348755295,0.167867946173484,0.26861033185621602]
["L-Tyrosine","HMDB0000158","C00082","Amino acids",27447596,"±",1720173.8029036501,26896994,"±",1903161.9052371799,25371574,"±",1454337.5079691799,0.67955518868070097,0.82297135953699696,0.53827070739062899,0.40547131208272102]
["L-Valine","HMDB0000883","C00183","Amino acids",1107531480,"±",185588860.406845,1136370540,"±",127604932.061271,1067340220,"±",107855507.64795201,0.94407352978571601,0.88986789791551602,0.74079135709838195,0.84703405153118305]
["ADP","HMDB0001341","C00008","Nucleotides",227134.96,"±",47183.662615068402,215418.04,"±",23154.221286853899,189702.58,"±",34472.855731595497,0.76175642286790601,0.82325263486432598,0.62538692588214995,0.47976743954052697]
["Adenosine monophosphate","HMDB0000045","C00020","Nucleotides",29119528,"±",2515326.6491738199,28084806,"±",3015215.4349160502,38826376,"±",2071879.9382073299,2.18924066634303E-2,0.78017446153519099,1.1850395429825701E-2,2.0120767219076501E-2]
["Adenosine","HMDB0000050","C00212","Nucleotides",57234852,"±",8179176.7244175598,107998462,"±",24341030.468878601,64103324,"±",12800948.1340241,0.102966603400569,5.1080212445433898E-2,8.5523769396864097E-2,0.77438993621714503,25,"Yes"]
["Adenine","HMDB0000034","C00147","Nucleotides",11310132.6,"±",1834941.9316954301,14410702,"±",1449295.96228445,10002431.4,"±",1248943.88434107,0.15478556392351001,0.177535404987892,6.4368646001352406E-2,0.55698093779223101]
["Guanosine monophosphate","HMDB0001397","C00144","Nucleotides",1365810.14,"±",152130.14519318499,1600079.8,"±",189789.13218369501,1696123.4,"±",118540.688284909,0.33970917686295798,0.309849572744966,0.67147818333690701,0.16071461363469899]
["Guanosine","HMDB0000133","C00387","Nucleotides",1911510.2,"±",545254.88041368301,4156473.4,"±",1060921.85432084,1846744.64,"±",758587.61155839998,0.11557171216005301,7.5581217403988293E-2,6.8519294323140995E-2,0.95617581984526501]
["Guanine","HMDB0000132","C00242","Nucleotides",3567024.38,"±",2118928.33264902,6874388,"±",2111921.5290606101,3340580.86,"±",2265825.74593165,0.45819805871947999,0.30164709470712397,0.271260435184144,0.94230786607359496]
["Cytidine monophosphate","HMDB0000095","C00055","Nucleotides",435611.64,"±",61121.669652870303,467949.88,"±",53041.136846870097,532117.42000000004,"±",119409.886695886,0.71308694078756496,0.78831906964396004,0.59586309188325504,0.42854467886170899]
["Cytidine","HMDB0000089","C00475","Nucleotides",129990.542,"±",33690.150291357597,91155.058000000005,"±",36064.2095211454,201114.93599999999,"±",53471.178178729999,0.21335073082856901,0.52566167931980501,8.8961388019032403E-2,0.25437299475939301]
["Cytosine","HMDB0000630","C00380","Nucleotides",183704.22,"±",12281.0945519282,181257.7,"±",21403.569332286599,144880.06,"±",21707.1268600107,0.305001713938226,0.92886124166515704,0.200182220047535,0.17356588564347]
["Thymidine","HMDB0000273","C00214","Nucleotides",82299.42,"±",16955.6515937445,74504.228000000003,"±",10812.246234687,79207.834000000003,"±",7103.8239961541803,0.90414138290464896,0.66238442267039899,0.79166692169639097,0.86204887062166502]
["Uridine 5'-monophosphate","HMDB0000288","C00105","Nucleotides",1731210.2,"±",185849.189030084,1658746,"±",181463.29098856301,2191375.7999999998,"±",177474.938744432,0.121149868721625,0.78266213848469202,6.0301189071412201E-2,9.8446954550951496E-2]
["Inosine monophosphate","HMDB0000175","C00130","Nucleotides",198651.98,"±",25803.6451465176,259608.36,"±",16045.791395459401,259379.26,"±",19924.242404708901,0.100204749071392,6.2359952513978002E-2,0.99396555749683602,6.3215986789327897E-2]
["Inosine","HMDB0000195","C00294","Nucleotides",9316290.1999999993,"±",3274703.0180449099,11650057.6,"±",2144495.26822695,5065910.2,"±",723727.22817401297,0.16400847476462499,0.48648702800545002,6.5620235480035802E-2,0.21547292223209499]
["Hypoxanthine","HMDB0000157","C00262","Nucleotides",35036929,"±",11996214.903854899,46379016,"±",9618677.2196261995,19909724,"±",2004994.6123857801,0.15344067995645,0.38795836763638503,5.8509842841880197E-2,0.25524756362180401]
["Xanthine","HMDB0000292","C00385","Nucleotides",1748060.08,"±",393792.73498822498,2333635.1,"±",540201.390788713,1460578.2,"±",130207.160088991,0.31332239099696302,0.31306824199544803,0.14239324821968999,0.61456843333163402]
["Allantoic acid","HMDB0001209","C00499","Nucleotides",735009.98,"±",72405.3413397064,877442.14,"±",136796.11202488799,551940.69999999995,"±",45946.265332135503,8.4120860377312007E-2,0.301172741647251,2.95371390601455E-2,0.19015177493716301]
["Allantoin","HMDB0000462","C01551","Nucleotides",211074.74,"±",26873.732895573001,259790.18,"±",28235.961481670802,321545.82,"±",44373.439285088098,0.11247314950665099,0.33234912636030001,0.22454142644602201,4.0876399537580703E-2]
["5-Hydroxyisourate","HMDB0030097","C11821","Nucleotides",7093860,"±",335794.37905361102,7252512.5999999996,"±",837725.414530179,9042552.8000000007,"±",569074.81135114399,8.2905705308262995E-2,0.85853207023283695,6.2344309222289403E-2,4.5048959604066199E-2]
["Urate","HMDB0000289","C00366","Nucleotides",2892862,"±",293138.96032564499,2790716,"±",255383.54453253199,2984645.4,"±",185370.772641374,0.86045678395226399,0.77642649159311605,0.59144979866615199,0.79852619922015]
["2',3'-Cyclic CMP","METPA0278","C02354","Nucleotides",44784.597999999998,"±",4218.4259573570798,56616.656000000003,"±",10697.304730291,56930.22,"±",6652.5365778287896,0.465772019295421,0.29677025387399703,0.97741309831985901,0.284740611135191]
["Dihydrothymine","HMDB0000079","C00906","Nucleotides",10335260.199999999,"±",1113185.7477698999,8897944.1999999993,"±",918077.88317922095,10804017,"±",1173946.46697164,0.44953640066177097,0.36264211232131899,0.23337911331144101,0.76289290504070695]
["Pyridoxamine 5'-phosphate","HMDB0001555","C00647","Nucleotides",234551.76,"±",12709.371883755701,320364.84000000003,"±",30591.787180019401,249452.54,"±",15392.8624591594,3.06238656194457E-2,1.39030148708023E-2,3.4915941420701299E-2,0.62638988599877798,null,"Yes"]
["Nicotinamide","HMDB0001406","C00153","Nucleotides",69344160,"±",9033560.6589356493,73461934,"±",8783576.8930530809,59351486,"±",4721912.3035721499,0.44283614250138598,0.71434548822183297,0.223260857960421,0.38096774457774502]
["Adenylosuccinic acid","HMDB0000536","C03794","Nucleotides",112526.402,"±",24582.135668240498,46500.686000000002,"±",10806.0732078524,71264.448000000004,"±",24575.416141298101,0.12206654323050201,4.6311765981173397E-2,0.42100203504085298,0.19027568334001099,7,"Yes"]
["Uridine diphosphate glucose","HMDB0000286","C00029","Nucleotides",32644.558000000001,"±",5514.2041077306903,33375.42,"±",4215.1009410463703,25928.406999999999,"±",5088.2192232458901,0.52392362317763397,0.91887884356510396,0.310099923757225,0.35803605662344201]
["Adenosine diphosphate ribose","HMDB0001178","C00301","Nucleotides",4975.3830200000002,"±",2662.0706914248999,5250.1229999999996,"±",2039.65568512651,3709.9764,"±",1368.2365970245601,0.85867872228599496,0.92751544931235896,0.61199080130308403,0.676313347147946]
["NAD","HMDB0000902","C00003","Nucleotides",6026859.7999999998,"±",778095.62489172199,6101474.7999999998,"±",918572.19166282204,6921257,"±",869792.19665009598,0.72186358694305697,0.95194928182808403,0.51184013525996697,0.47495678738604802]
["NADH","HMDB0001487","C00004","Nucleotides",272382.84000000003,"±",51353.130109026497,295460.34000000003,"±",55258.382685368197,336761.14,"±",42032.056084726602,0.66140584628052301,0.74908184571510805,0.56889632692028602,0.379196320931449]
["Phosphate","HMDB0001429","C00009","Phosphates",29016992,"±",2605138.0773605802,38099678,"±",3040785.6589858499,32840954,"±",1935138.5811657,7.9277024236544397E-2,2.7847652246133399E-2,0.17317433130433799,0.31303925683792899,null,"Yes"]
["Pyrophosphate","HMDB0000250","C00013","Phosphates",644782.64,"±",130333.86398485101,968161.42,"±",222221.08894643301,757517.12,"±",101612.81503266899,0.37873659947229998,0.17819756745441601,0.369924312047272,0.62709929449883495]
["D-Glucose","HMDB0000122","C00031","Glycolysis",3976461.6,"±",373457.26367452001,4476368.2,"±",168581.68733062301,4009966.2,"±",362502.50567691203,0.47914511353071698,0.284984202497713,0.31700411939391998,0.94144556947133795]
["Glucose 6-phosphate","HMDB0001401","C00092","Glycolysis",5410861.2000000002,"±",744296.41354996501,6981368.2000000002,"±",1242090.05810394,5247989.5999999996,"±",996312.43271955603,0.43619937139208398,0.29529012386581699,0.250383018285327,0.91151948523572301]
["Fructose 1,6-bisphosphate","HMDB0001058","C00354","Glycolysis",12535.6234,"±",1696.5605562253199,19154.310000000001,"±",1478.19445015871,11610.843800000001,"±",2128.8250986031799,2.24990985530014E-2,2.2512877186277199E-2,1.14314273728851E-2,0.72099689831178404,null,"Yes"]
["D-Glyceraldehyde 3-phosphate","HMDB0001112","C00661","Glycolysis",116883.71799999999,"±",13121.386516307,120344.2,"±",13082.650496210599,94497.356,"±",4925.3711773150599,0.24084496907185701,0.82876527345344098,0.124625728010713,0.17822147599645699]
["2-Phospho-D-glyceric acid","HMDB0003391","C00631","Glycolysis",20943.214,"±",3906.7102591241701,45756.648000000001,"±",9028.0629015555696,13830.358,"±",911.559501631133,4.7479608644998197E-3,9.6061673844886706E-3,1.90032146385634E-3,0.39520873389743699,15,"Yes"]
["Phosphoenolpyruvate","HMDB0000263","C00074","Glycolysis",1645.4358999999999,"±",348.21272539700499,4719.5853999999999,"±",879.79163530739504,1125.14544,"±",143.70237003053799,1.2182496142887399E-3,1.98416514560099E-3,6.1108183895331098E-4,0.518118666253783,5,"Yes"]
["Pyruvate","HMDB0000243","C00022","Glycolysis",987870.06,"±",26020.0088522199,970090.7,"±",22893.193052564799,955917.34,"±",50955.0307056487,0.81942510482629005,0.72995308142513404,0.78298248436569995,0.53732271302474199]
["Lactate","HMDB0000190","C00186","Glycolysis",15558302,"±",659310.86455025105,16832318,"±",215694.12881207501,15656842,"±",752328.25856403902,0.27523538369567302,0.15323066817400799,0.184845157171484,0.90807063657126597]
["D-Maltose","HMDB0000163","C00208","Other sugars",6952.5853999999999,"±",2367.18312218237,10632.4164,"±",1482.76286938251,6274.4539999999997,"±",1435.3796774346099,0.22868387258141101,0.176807030850611,0.11496442017113701,0.79590975646277595]
["Mannitol","HMDB0000765","C00392","Other sugars",16516.616000000002,"±",1618.6323805132499,26068.222000000002,"±",5170.9153981731297,17772.243999999999,"±",4553.9046592024697,0.239605646785712,0.124276512746058,0.176687999691058,0.83164683431463504]
["D-Ribose","HMDB0000283","C00121","Other sugars",139460.72,"±",10537.690352415901,141618.32,"±",11815.699759912701,128029.71799999999,"±",11488.4735046839,0.66751797745844799,0.894780484575318,0.41153767159943799,0.48786548184461598]
["D-Arabitol","HMDB0000568","C01904","Other sugars",21401.921999999999,"±",2836.2345067719598,28006.558000000001,"±",6344.0891382966902,20802.741999999998,"±",2333.63084617812,0.43532105724902698,0.29146534923956102,0.25196397614527999,0.92191246846695496]
["Citrate","HMDB0000094","C00158","TCA cycle",159809.122,"±",27738.431039748499,182611.9,"±",22453.422440153699,140172.99799999999,"±",14515.7002393238,0.42793457956792902,0.48241265789940502,0.20220400560306601,0.54416315177269003]
["alpha-Ketoglutarate","HMDB0000208","C00026","TCA cycle",87223.025999999998,"±",9225.7630759762105,68050.615999999995,"±",3866.5917226810998,73946.678,"±",2581.43756500985,0.10680944815136501,4.2216056652145097E-2,0.49788734550650499,0.14148808393168499,19,"Yes"]
["2-Keto-glutaramic acid","HMDB0001552","C00940","TCA cycle",83482.559999999998,"±",8112.2419606838603,77910.331999999995,"±",4244.9280200333196,81413.521999999997,"±",4656.6674948673299,0.80136174585742104,0.51900425012192697,0.68354796695860998,0.80931312953736601]
["Succinate","HMDB0000254","C00042","TCA cycle",2039530.32,"±",516871.52012758702,2534504.4,"±",615373.26332938799,3921362.6,"±",447981.277847144,6.8833727126486804E-2,0.52241395466247598,8.9677394943430896E-2,2.7660991470266599E-2]
["Malate","HMDB0000156","C00149","TCA cycle",23676408,"±",1888828.02504198,22857192,"±",2367080.0124592301,20651964,"±",1248964.3658471601,0.52318438449883697,0.764633883524094,0.42574583416078099,0.28024161770429101]
["Oxaloacetate","HMDB0000223","C00036","TCA cycle",125599.54,"±",7054.2191395362797,101576.868,"±",5324.2464899010802,112367.22,"±",4020.2974894154299,3.2761712912204498E-2,1.04622423271008E-2,0.198495677843467,0.12095137835049199,14,"Yes"]
["2-Hydroxyglutarate","HMDB0000694","C03196","Alternative Carboxylic acids",94221.71,"±",12155.0392788518,108191.39,"±",18709.9858122183,68673.665999999997,"±",4827.8896983760897,0.14148698639212401,0.46800248721229998,5.5518546614651297E-2,0.19556865401055601]
["6-Phosphogluconic acid","HMDB0001316","C00345","Pentose Phosphate Pathway",57162.302000000003,"±",7136.7234342024203,49667.256000000001,"±",8028.3355583374796,36804.688000000002,"±",5643.5798341933596,0.15804376060932299,0.46394070832782403,0.21859207429192601,6.2343912239943601E-2]
["6-Phosphonoglucono-D-lactone","HMDB0001127","C01236","Pentose Phosphate Pathway",4017.9238,"±",745.30342235873297,7066.9637000000002,"±",3326.6459172220598,2207.5347999999999,"±",825.24482199794204,0.26837421746067802,0.30799380854575398,0.115501443515119,0.53915533569413598]
["D-Erythrose 4-phosphate","HMDB0001321","C00279","Pentose Phosphate Pathway",38606.254000000001,"±",6378.2912573694803,43905.408000000003,"±",7242.5397065817997,34922.720000000001,"±",5194.6464600634699,0.61338175340721102,0.56473167393176005,0.33529314657910397,0.68787220143784999]
["Sedoheptulose 7-phosphate","HMDB0001068","C00281","Pentose Phosphate Pathway",2149506.6,"±",290771.20122453698,2334503.2000000002,"±",252111.479205212,2119353,"±",234763.409641707,0.82114338981407797,0.62434052319084898,0.56969470400208699,0.93605947011593005]
["Ribose phosphate","HMDB0001548","C00117","Pentose Phosphate Pathway",804093.26,"±",159214.39707272299,1034065.14,"±",207902.630947806,595473.18000000005,"±",65311.502512378298,0.18036190662089999,0.31723215020558998,6.9828243418777802E-2,0.36245602182795]
["Phosphoribosyl pyrophosphate","HMDB0000280","C00119","Pentose Phosphate Pathway",78981.843999999997,"±",12204.664222814799,71838.198000000004,"±",18405.4191375685,68346.672000000006,"±",9090.2513057689393,0.85845304220210705,0.72048150395523403,0.86088046679008901,0.59546608678048896]
["Glutathione","HMDB0000125","C00051","GSH homeostasis",161261676,"±",18450174.135112502,203857520,"±",8365116.8948437301,230232500,"±",16629202.475735299,2.2533764844509599E-2,6.9808514512216605E-2,0.24136508844702501,7.3137226496324996E-3]
["Oxidized glutathione","HMDB0003337","C00127","GSH homeostasis",187548.57,"±",73661.119810629403,230107.06,"±",15805.2180278097,267967,"±",33189.858764839599,0.50822369963129599,0.53851903902321396,0.58364043383034503,0.25464903027980201]
["Pyroglutamic acid","HMDB0000267","C01879","GSH homeostasis",106584538,"±",5112165.0434100796,123700720,"±",10144544.9264814,137978620,"±",4376507.5385974096,2.6316132630246201E-2,0.110723130782806,0.17643352481713201,8.2450407096751593E-3]
["S-Glutathionyl-L-cysteine","METPA0607","C05526","GSH homeostasis",704809.16,"±",145614.90166797399,629242.78,"±",38764.926260672801,814385.82,"±",108989.137528936,0.49252481257460901,0.62771981856158299,0.24615705469973401,0.48434132346756098]
["Cysteinylglycine","HMDB0000078","C01419","GSH homeostasis",9504608.8000000007,"±",2647100.0564432698,6667684.4000000004,"±",704937.62385941599,10483256,"±",1586713.73361914,0.341769528725959,0.293939015221792,0.16565401877106301,0.71158564362685695]
["Ascorbate","HMDB0000044","C00072","GSH homeostasis",4472211.8,"±",696965.54035105603,3349716.8,"±",633637.96047864703,3701113,"±",294925.87840760901,0.391446542010217,0.188939438326158,0.67056053195635801,0.35754620375866097]
["Dehydroascorbate","HMDB0001264","C00425","GSH homeostasis",492397.5,"±",74602.184324508897,345481.88,"±",28973.959441805699,418383.04,"±",41441.1346341362,0.17890538613465201,6.9075778638605298E-2,0.34139161073976498,0.334352422274588,22,"Yes"]
["Gamma-Glutamylcysteine","HMDB0001049","C00669","Gamma-glutamyls",2693103.5,"±",965906.40504156298,1207547.6000000001,"±",183951.02535693799,1911881.36,"±",472917.169658673,0.28607570534644,0.121270761317446,0.44451229903677097,0.39774382569153999]
["Gamma-Glutamyl-Se-methylselenocysteine","HMDB0010716","C05695","Gamma-glutamyls",850109.74,"±",154436.866688763,909085.5,"±",116774.005775686,844876.18,"±",72746.391928083904,0.91529916211082796,0.73297266412567197,0.71043053213944896,0.97578663708381597]
["5-L-Glutamyl-L-alanine","HMDB0006248","C03740","Gamma-glutamyls",3615277.4,"±",986952.93339579296,2617565,"±",387302.55216794001,2909671.8,"±",450470.604276283,0.56714335671399696,0.30968484124644702,0.76145999627391803,0.46759447662943898]
["4-(Glutamylamino) butanoate","HMDB0012161","C15767","Gamma-glutamyls",518521.88,"±",53762.692460938,372690.72,"±",33370.101075834304,475380.32,"±",61993.046573913402,0.15972749451316101,6.6725450818181806E-2,0.18112956128771401,0.56194732576706097,10,"Yes"]
["Gamma-glutamyl-L-putrescine","HMDB0012230","C15699","Gamma-glutamyls",103543.39,"±",28135.2089196999,152005.89199999999,"±",43911.156790253503,118351.51,"±",15196.553316035201,0.55078824185096698,0.29599089996018102,0.462620435371492,0.74423717644258702]
["Gamma-Glutamyl Glutamine","HMDB11738","C05283","Gamma-glutamyls",25090769.600000001,"±",7990376.9735346399,17382284,"±",2224865.2710997998,20215879.399999999,"±",4007056.7492453102,0.59764332092634498,0.32562725229356099,0.71293844316291699,0.52909304746125696]
["5-L-Glutamyl-taurine","HMDB0004195","C05844","Gamma-glutamyls",420198.26,"±",109478.21885116999,217553.2,"±",11401.452708361299,344905.3,"±",98574.360010060394,0.27470432720822002,0.11884131251825999,0.31193859041935401,0.54424861794954904,17,"Yes"]
["L-Homocysteine","HMDB0000742","C00155","Serine biosynthesis and one-carbon metabolism",439740.24,"±",74901.810649446896,367521.5,"±",41517.079058467003,357579.32,"±",24223.319693869402,0.48821523908043402,0.33992239399780499,0.89344289357676698,0.28029377258076299]
["L-Cystathionine","HMDB0000099","C02291","Serine biosynthesis and one-carbon metabolism",357657.424,"±",167304.965230084,357333.62400000001,"±",105870.68025552901,337299.56,"±",132938.855678288,0.99285673252242401,0.99870050522079801,0.91975135012084297,0.918459401738147]
["Dimethylglycine","HMDB0000092","C01026","Serine biosynthesis and one-carbon metabolism",15646600,"±",1574089.8591789501,16049470.800000001,"±",2762583.31501851,16102682,"±",820605.16009467095,0.98287076763955605,0.883056160420023,0.98449219705357705,0.86776134679202299]
["Phosphoserine","HMDB0000272","C01005","Serine biosynthesis and one-carbon metabolism",36267.944000000003,"±",5447.0718713797096,21002.129000000001,"±",6392.9395338972199,28553.026000000002,"±",6952.6197362933699,0.26845528203291802,0.11206686761114699,0.41293342980881798,0.40315093544858299,21,"Yes"]
["S-Adenosylhomocysteine","HMDB0000939","C00021","Serine biosynthesis and one-carbon metabolism",1757660.56,"±",315942.69881048601,1743058.8,"±",215604.62320979999,1244777.3,"±",118617.944241965,0.24310553282880401,0.96511583604798301,0.153448993618436,0.142734651084782]
["S-Adenosylmethionine","HMDB0001185","C00019","Serine biosynthesis and one-carbon metabolism",1762468.8,"±",221600.879135756,1943375.8,"±",235643.46536651501,1464192.4,"±",194031.45203151999,0.32541376194204802,0.56783185280706805,0.145708688417751,0.35192273375879002]
["L-Homoserine","HMDB0000719","C00263","Serine biosynthesis and one-carbon metabolism",1794394.8,"±",54259.706490544202,1827581.2,"±",57590.9191169927,1901216.6,"±",77223.735215023102,0.50054327520813202,0.71956229201780597,0.43057666874675599,0.25960492853891998]
["Ornithine","HMDB0000214","C00077","Urea cycle",5342254.4000000004,"±",487352.34089697403,8405247.1999999993,"±",1215696.3317315499,6169058.4000000004,"±",361366.03124333598,4.44593688046327E-2,1.7245639685928099E-2,6.6782172640529505E-2,0.47043764674947902,null,"Yes"]
["Citrulline","HMDB0000904","C00327","Urea cycle",5412857,"±",910538.10319294198,7072361.7999999998,"±",2741230.7583024199,3745484.2,"±",1237741.2122428301,0.455354289798863,0.529961262800699,0.21914941648779901,0.528045435346575]
["Argininosuccinic acid","HMDB0000052","C03406","Urea cycle",559037.81999999995,"±",148530.758789018,397590.76,"±",51816.660807288601,343522.9,"±",73149.966208563594,0.320430132035457,0.276627198333533,0.70935748479302796,0.15405053661694701]
["Putrescine","HMDB0001414","C00134","Polyamines",267539.62,"±",38248.246880274099,270942.82,"±",43068.512314977903,266069.18,"±",37849.362519141599,0.99606241975541099,0.952773689312294,0.93241520946005796,0.97958370233953096]
["Spermidine","HMDB0001257","C00315","Polyamines",449927.8,"±",27300.556805237498,443311.2,"±",74497.104484785203,283508.12,"±",55715.7662854097,9.8164346309819406E-2,0.93476420617234401,6.6431531673605895E-2,5.7307467328715701E-2]
["Spermine","HMDB0001256","C00750","Polyamines",39240.171999999999,"±",7741.5753958728601,36617.585800000001,"±",10996.55426356,21000.813900000001,"±",6174.6999879650602,0.30027575858424299,0.83181190304586905,0.22051665504884399,0.15702910747256901]
["N-Acetyl-9-O-acetylneuraminic acid","HMDB0000794",null,"Aminosugars",274039.32,"±",14830.0279636756,324942.76,"±",16785.910346734301,300220.53999999998,"±",18285.0187037531,0.14013923701700301,5.2067940976792203E-2,0.31565275526015202,0.28917111048787802,null,"Yes"]
["N-Glycolylneuraminic acid","HMDB0000833","C03410","Aminosugars",218562.7,"±",26267.105280121799,229570.62,"±",29070.6457069223,146175.04000000001,"±",11125.0809281371,5.5589125833828197E-2,0.74634049347019205,2.7520243685959001E-2,5.0184737750788501E-2]
["alpha-D-Glucosamine 1-phosphate","HMDB0001109",null,"Aminosugars",369263.02,"±",42339.298318552697,425806.78,"±",56419.146031771903,439206.52,"±",22799.3237807265,0.49225315492643901,0.36863463415129299,0.82851959631744199,0.27035668401360002]
["Glucosamine","HMDB0001514","C00329","Aminosugars",95365.797999999995,"±",13751.105365431,130135.02,"±",7484.0363545616201,107968.14,"±",3287.45939801543,5.8415654196301597E-2,2.07175462434263E-2,0.115439808291725,0.353670206846877,8,"Yes"]
["L-Arabinose","HMDB0000646","C00259","Aminosugars",467647,"±",45351.456120316601,565867.36,"±",35368.453203958503,425500.98,"±",32094.768159614399,6.00601041439799E-2,9.2744724129733003E-2,2.2792611882695001E-2,0.44838872454886097]
["1,4-beta-D-Xylan","METPA0277","C02352","Aminosugars",145946.4,"±",9940.7957321333197,166232.9,"±",7989.5209883321504,147101.01999999999,"±",13028.4307340293,0.34291573721026403,0.19797711663440901,0.22296638647757,0.93945327222370201]
["UDP-N-acetyl-D-glucosamine","METPA1612","G10610","Aminosugars",207054.96,"±",39373.586662210502,258105.492,"±",69937.720112644995,272153.2,"±",45414.915478672898,0.67009470793418302,0.510631464318134,0.85511617439691201,0.40422552493160602]
["Cytidine monophosphate N-acetylneuraminic acid","HMDB0001176","C00128","Aminosugars",70298.085999999996,"±",2324.8089187621399,80660.62,"±",6769.7854958299804,84116.466,"±",11600.849941549401,0.45763041974212099,0.37018192306887099,0.76150829592810698,0.238124298003664]
["Beta-L-arabinose 1-phosphate","HMDB0012195","C03906","Aminosugars",264100.52,"±",50403.516558762101,395067.1,"±",71559.025122111605,228887.24,"±",17114.653658009,9.4381344747782606E-2,9.7281129496384802E-2,4.1523037215489202E-2,0.63739739563657605]
["Carnosine","HMDB0000033","C00386","Arginine and proline metabolism",313856.12,"±",15290.0023376519,534691.19999999995,"±",21722.468713891602,398845.62,"±",46030.833547616698,9.3758614484072797E-4,2.6657247032992602E-4,8.6829052604900196E-3,7.3815235105226695E-2,2,"Yes"]
["5-Guanidino-2-oxopentanoate","HMDB0004225","C03771","Arginine and proline metabolism",3058180.6,"±",1298094.04064253,2206385.64,"±",453433.600022814,1813028.34,"±",285393.59319372498,0.55619679102321895,0.47185001793275499,0.73748928213922704,0.29884123431864501]
["Phosphocreatine","HMDB0001511","C02305","Arginine and proline metabolism",2390308.2000000002,"±",748435.59573382104,1867165,"±",208824.307422771,2117837.2000000002,"±",238643.89515036799,0.73855624450625401,0.44584791048483102,0.71225053898925195,0.68864298235021204]
["Creatine","HMDB0000064","C00300","Arginine and proline metabolism",1149173500,"±",138889283.21814501,1124678140,"±",189862485.16452,1178040800,"±",58351576.116159901,0.96432438418793298,0.90353833418228202,0.79200812422894495,0.88644359906363401]
["Creatinine","HMDB0000562","C00791","Arginine and proline metabolism",16717024,"±",674062.41005266004,21249318,"±",1986048.6716906,18693866,"±",671809.69329565298,7.7259110942969902E-2,2.6883740803298299E-2,0.180736511190109,0.29317417400623302,null,"Yes"]
["4-Acetamidobutanoic acid","HMDB0003681","C02946","Arginine and proline metabolism",1121525.82,"±",190718.03389856601,1313013.6000000001,"±",103466.859837631,890617.42,"±",39941.243054133898,0.103449039240123,0.30870126133075698,3.7057141842346097E-2,0.22410886624203799]
["N-a-Acetylcitrulline","HMDB0000856","C15532","Arginine and proline metabolism",152738.236,"±",40960.920228160103,214754.13800000001,"±",54065.589053333599,191493.54,"±",11668.827382158001,0.55352060993180996,0.29142383130660998,0.68623732980764596,0.50353860421810603]
["N-Acetylornithine","HMDB0003357","C00437","Arginine and proline metabolism",1508078.2,"±",137950.19227656,924457.98,"±",89785.412374095598,2034680.4,"±",226978.21338723201,1.48171881453473E-3,2.54946745108856E-2,3.9844658630951201E-4,4.0174690202988902E-2,1,"Yes"]
["Guanidoacetic acid","HMDB0000128","C00581","Arginine and proline metabolism",731337.36,"±",77768.436967850896,1279752.5,"±",154387.251748323,814731.72,"±",113370.480126369,1.46457755204304E-2,6.9686352569602802E-3,1.7440322459371702E-2,0.63017988820426696,4,"Yes"]
["4-Hydroxyproline","HMDB0000725","C01157","Arginine and proline metabolism",50912108,"±",4549635.4553144099,68603868,"±",3365702.7144080899,62307532,"±",6290643.4525121497,6.8964949298832595E-2,2.49683906562847E-2,0.38006098507062203,0.124981027200174,9,"Yes"]
["Pyrroline hydroxycarboxylic acid","HMDB0001369","C04281","Arginine and proline metabolism",2247684,"±",360604.130685576,1676238.6,"±",283772.07856827602,1514573,"±",136486.75153398601,0.18593278809227601,0.16945386603711299,0.68647348896571103,8.5256594087497001E-2]
["Pantothenol","HMDB0004231","C05944","Panthothenate metabolism",782628.34,"±",22190.511399798801,873544.4,"±",104751.323747068,961908.48,"±",52074.835385264501,0.223771015535006,0.36813569445260902,0.381281924462123,8.9986598650262303E-2]
["Dihydrouracil","HMDB0000076","C00429","Panthothenate metabolism",825292.7,"±",55932.878373180502,890728.84,"±",46473.056705263101,810279.28,"±",43392.329617795403,0.48651540667855703,0.36261830587467098,0.267230643683046,0.83175040436728798]
["Taurine","HMDB0000251","C00245","Sulfur metabolism",53773036,"±",2466890.6248121299,54068520,"±",2324784.1887388201,61823212,"±",3339140.2626116201,0.103162534448746,0.94062680629373396,6.9132157868974101E-2,6.0461952699873797E-2,20,"No"]
["Hypotaurine","HMDB0000965","C00519","Sulfur metabolism",10585877.800000001,"±",2571031.8465246698,5419428.7999999998,"±",1541037.2845681401,6816887.5999999996,"±",627092.614695278,0.14430789639740499,6.1095018377359499E-2,0.58651757061661203,0.15759106395779199,18,"Yes"]
["Thiocysteine","HMDB0003585","C01962","Sulfur metabolism",123131.26,"±",6499.0096271355096,117045.394,"±",5470.3033077185,112385.454,"±",7305.8813660787,0.51859116039103803,0.51847561885540205,0.61972467589519797,0.26292880608388702]
["Selenomethionine","HMDB0003966","C05335","Sulfur metabolism",20822.324000000001,"±",7605.3468094733198,16311.2336,"±",4303.9490469826596,15983.592199999999,"±",2835.8444593221002,0.77537845577872599,0.55878725061107604,0.965880119279379,0.53103990958954705]
["Cysteic acid","HMDB0002757","C00506","Sulfur metabolism",210203.978,"±",62149.981295397702,141069.848,"±",23891.9317478622,153212.07399999999,"±",26918.060377523001,0.47505701546953399,0.26126503744541801,0.83943283167739202,0.35028890209202701]
["S-Lactoylglutathione","HMDB0001066","C03451","Sulfur metabolism",343676.42,"±",89189.874160536798,519928.56,"±",47426.534943084298,446669.56,"±",43669.875829393,0.185923746462444,7.3440666356226897E-2,0.43078961006092598,0.27405458038930702]
["L-Methionine S-oxide","METPA0344","C02989","Sulfur metabolism",2866952.6,"±",918800.48306461005,1965832.3,"±",442846.32150475198,2943480.6,"±",516898.66097104602,0.52592370765512697,0.353502878283946,0.31566462564124398,0.93602317134482105]
["L-Kynurenine","HMDB0000684","C00328","Indole and Tryptophan",250765.9,"±",23359.1933966693,273956.59999999998,"±",71242.931614546906,395414.06,"±",120976.374827826,0.43464417434720298,0.84516496432170396,0.31654110327268298,0.236991035449855]
["Glycerol 3-phosphate","HMDB0000126","C00093","Glycerophospholipid biosynthesis",37929374,"±",1269229.92543353,39408164,"±",2284656.5505007501,34029934,"±",2086065.8659294499,0.16878398527164901,0.59799926471312803,7.2384280475309801E-2,0.17874630908309799]
["O-Phosphoethanolamine","HMDB0000224","C00346","Glycerophospholipid biosynthesis",27959780,"±",1380309.3839100001,32724680,"±",773344.67353826098,26967348,"±",2183552.2090927898,4.9307712467831201E-2,5.13252084250507E-2,2.2594415787412999E-2,0.66020088315802905,null,"Yes"]
["N-Methylethanolamine phosphate","METPA0145","C01210","Glycerophospholipid biosynthesis",5772819.7999999998,"±",1245799.0984678201,4992572.8,"±",722167.17517167702,5199928.2,"±",591355.81326003699,0.81965397334456502,0.55075882309680102,0.87312280074926596,0.66021776540477095]
["sn-glycero-3-Phosphoethanolamine","NA","NA","Glycerophospholipid biosynthesis",15052404,"±",1774511.6368077199,21223418,"±",3482804.7889759801,19531312,"±",1411060.2962467601,0.212640607253654,9.3988938817681097E-2,0.62701506841469601,0.211462694997854]
["CDP-choline","HMDB0001413","C00307","Glycerophospholipid biosynthesis",790258.36,"±",70999.000493433705,1044136.44,"±",91616.882128424404,1034471.86,"±",36713.606971661102,4.1416372091973602E-2,2.5121488783463899E-2,0.92405201322494801,3.0036071001861401E-2,23,"Yes"]
["L-Carnitine","HMDB0000062","C00318","Carnitine and fatty acid metabolsim",271634660,"±",20077182.082070202,223694460,"±",22323374.384299502,281197380,"±",16575443.5761279,0.13078510308906099,0.112589113692907,6.2481493366022697E-2,0.73863219011536596,3,"Yes"]
["Acetylphosphate","HMDB0001494","C00227","Other",16392.8086,"±",3239.5623652691102,25496.421999999999,"±",2859.4321205361698,19334.277999999998,"±",2916.3207872615799,0.134471645311733,5.3707679884595898E-2,0.173313141486409,0.50267655765919905,null,"Yes"]
["N5-Methyl-L-glutamine","NA","NA","Other",2858563.68,"±",709019.98736082402,1419090.32,"±",312763.69385153602,2809500.6,"±",737580.90692049498,0.215196438287382,0.12528861831942401,0.13742966634270101,0.956133069409,16,"Yes"]
["2-Methyleneglutarate","HMDB0000422",null,"Other",1008329.64,"±",119860.29825802401,1065111.72,"±",85444.334205899198,951063.02,"±",53836.5959129884,0.68077288977562,0.66515133422744899,0.39034434493971798,0.66249191282063402]
["Dyspropterin","HMDB0001195","C03684","Other",248143.6,"±",15672.6219760447,344201.58,"±",16464.195467298101,295290.84000000003,"±",18351.130616902101,5.9135356755950401E-3,1.6780873779150801E-3,6.2817660575615705E-2,7.1533190416961406E-2,13,"Yes"]
["p-Aminobenzoic acid","HMDB0001392","C00568","Other",1268273,"±",462895.03473879199,441396.68,"±",105918.91529248899,1026120.52,"±",185643.25672797899,0.16698165156403799,7.0327555621374604E-2,0.18549671702228299,0.57154597132846496]
["Leucocyanidin","METPA1714","C05906","Other",978318.42,"±",265500.12458264601,1333039.5,"±",243197.34653425001,1379614,"±",62154.6192917308,0.36963573209696599,0.25742301507343701,0.87853485788117802,0.20344583169084701]
["3-Oxalomalate","METPA0238","C01990","Other",1114667.6000000001,"±",59285.744027211098,1108536.8799999999,"±",110981.761598856,1322242.6000000001,"±",79678.058960167997,0.17775683287317301,0.96061994184817801,0.104302166698124,0.113539144046817]
["2-Deoxy-alpha-D-glucoside","NA","NA","Other",5310288,"±",209237.73439129,6130111.2000000002,"±",338351.70498320198,4988395.5999999996,"±",422321.603413039,8.2789478220269094E-2,0.109130000820993,3.2906780852682997E-2,0.50971794368674195]
["4-Hydroxycinmic acid","NA","NA","Other",2973570,"±",160241.375343886,3007413.4,"±",186905.417500296,2857088.6,"±",197658.99590775001,0.83169165657313604,0.897725126492118,0.57059651375684695,0.65943271177670904]
["N(6)-Methyllysine","HMDB0002038","C02728","Other",252881.96,"±",16811.147497348298,260693.88,"±",14039.012135381899,264439.38,"±",18576.243076262799,0.88235565114077397,0.74477351438754003,0.87575127597747904,0.63099668417390797]
["Di-2-propenyl sulfide","NA","NA","Other",99844.462,"±",15597.132199109001,98830.953999999998,"±",24562.1631911722,52981.11,"±",6852.9848573610598,0.13225709275379599,0.96755970673944702,8.4806036235127696E-2,7.8927084723653201E-2]
["Shikimate 3-phosphate","METPA0369","C03175","Other",338320.82,"±",64819.838417797699,416955.52,"±",65362.338095706204,385141.14,"±",42236.194391334502,0.64340445612295005,0.36041607306202,0.70717732835786196,0.58170571819741701]
["Gluconolactone","HMDB0000150","C00198","Other",578843.28,"±",52263.137864439399,654363.36,"±",36322.343569511002,565502.74,"±",51093.895328146602,0.38516129057092902,0.27924170822243699,0.207146195806581,0.84468593287573701]
["2-Dehydro-3-deoxy-D-glucarate","METPA0444","C03921","Other",555309.62,"±",47254.283658483298,792953.28,"±",102729.128210486,639101.18000000005,"±",41566.593396830103,8.7626612971254694E-2,3.2560587375058E-2,0.143777854443289,0.41098725512492701,null,"Yes"]
["Dihydroflavonol","NA","NA","Other",125684.568,"±",33342.802246814703,277923.53999999998,"±",66744.065449892994,198904.19399999999,"±",41545.544669370203,0.13426569055715101,4.9591537798862599E-2,0.27922902280342798,0.31435763322327198,null,"Yes"]
["6-Thioxanthine 5--monophosphate","NA","NA","Other",23921.9202,"±",9110.8054530333902,51718.993999999999,"±",16643.309729838202,14570.3506,"±",4518.9908836741597,9.1126203296948496E-2,0.10643293930595001,3.78867262469397E-2,0.56794655155585505]
["D-Ribitol 5-phosphate","METPA0121","C01068","Other",81971.11,"±",6881.1864161937901,76742.423999999999,"±",5741.0672480093799,60431.868000000002,"±",5426.7166222361402,6.5517146170515794E-2,0.55243963854144895,8.0775549758732607E-2,2.7008613692803898E-2]
["Ribose 1,5-bisphosphate","HMDB0011688","C01151","Other",31398.488000000001,"±",2844.75008102012,37290.038,"±",8291.2073716120503,35120.663999999997,"±",8279.4841952368006,0.83488290527615605,0.56067943679145205,0.82930098337876601,0.71197637418390103]
["1-O-Galloyl-beta-D-glucose","NA","NA","Other",34619.341999999997,"±",10366.0853205269,31002.314399999999,"±",9153.2250458372,24752.428800000002,"±",9680.9651984842603,0.77356428631782703,0.79744397645172804,0.658317260482155,0.48776658106861998]
["Guanidinosuccinic acid","HMDB0003157","C03139","Other",1528383.9,"±",268673.71165608999,1150161.2,"±",325484.72114399599,2049021.8,"±",255424.572575036,0.122772986707292,0.36625143626731199,4.5483739086291899E-2,0.220498247829856]
["Hydroxyacetone phosphate","NA","NA","Other",228228.26,"±",10296.134081226801,241681,"±",20859.710244536,211828.32,"±",14923.045535794599,0.44073604753912499,0.56215103665909005,0.21052232037954999,0.48131332747530298]
["beta-D-Glucuronoside","NA","NA","Other",137846.82,"±",15755.728248589499,128260.026,"±",18877.433600642798,97071.07,"±",8242.3112526924106,0.174333526963066,0.65880341534893505,0.166503542211173,7.8162587163788502E-2]
["Oxalosuccinic acid","HMDB0003974","C05379","Other",18852.292000000001,"±",3003.9980932939998,24170.116000000002,"±",2718.1411622515102,17319.646000000001,"±",3150.4076684749898,0.268011822797532,0.228471040236715,0.128020765645703,0.72090742796390905]
["Carglumic acid","HMDB0015673","C05829","Other",619635.22,"±",56232.943054889103,655721.1,"±",38906.218598226696,706476.6,"±",30665.302081587299,0.39094712632643402,0.56630278328960804,0.423025098958421,0.181283768524932]
["2-Oxo-7-methylthioheptanoic acid","METPA1749","C17220","Other",42487.491999999998,"±",16067.1866099256,21140.117999999999,"±",3099.1808248655002,27560.256000000001,"±",2750.08635965964,0.30650330113336199,0.14108161748025999,0.64409029843006105,0.292155552049159]
["Homocitrulline","HMDB0000679","C02427","Other",653679.28,"±",129322.29562185099,653238.92000000004,"±",121106.019907804,606873.57999999996,"±",59178.755792660901,0.93999563521304697,0.99774375621520195,0.76633684390213996,0.76419136309268898]
["Homomethionine","METPA1742","C17213","Other",201491.04,"±",33934.196114415303,174975.41399999999,"±",52930.793665931298,240531.72,"±",36585.472656238802,0.55606984186614505,0.66323840947456303,0.29135199465786199,0.523393801384613]
["Data represented as mean ± SEM. ANOVA with fixed effect for maternal diet. P < 0.05 by Student's t-test."]
["VIP rank from PLS-DA with metabolites, acylcarnitines, and bile acids."]
["Features submitted for pathway analysis are indicated ('Yes') to include the top 25 features from VIP rank with P < 0.15 in CON vs OB-WSD or features with P < 0.05 by t-test in CON vs OB-WSD. Features from the top 25 VIP rank with P > 0.15 in CON vs OB-WSD were excluded from pathway analysis (indicated with 'No')."]
["KEGG, Kyoto Encyclopedia of Genes and Genomes; NA, not available; PLS-DA, partial least squares discriminant analysis; VIP, variable importance in projection."]

{"sheet":"Table S3","index":2,"n_rows":28,"n_cols":16,"rows_kept":28,"cut":false,"hidden":false,"merged":[[2,1,2,3],[2,4,2,6],[2,7,2,9],[1,11,1,13],[26,0,26,15]]}
["Table S3. Acylcarnitine concentrations in the fetal liver"]
[{"$nulls":11},"P-value"]
["Acylcarnitine (fmol/mg tissue)","CON",null,null,"OB-WSD",null,null,"OB-DR",null,null,"ANOVA","CON vs OB-WSD","OB-WSD vs OB-DR","CON vs OB-DR","VIP Rank","Pathway"]
["short (C4-C5)",6009.2,"±",1190.752,4490,"±",656.26210000000003,5920,"±",912.07460000000003,0.466342561007689,0.27794780959800502,0.30578265592452197,0.94789730026074903]
["medium (C6-C10)",1440.2,"±",486.85789999999997,1935.8,"±",504.63979999999998,1400.4,"±",317.50459999999998,0.64765359719997995,0.445671179602878,0.41095858503598598,0.95054930306009]
["long (C12-C20)",1638.4,"±",185.37549999999999,2345.1999999999998,"±",488.55950000000001,1525,"±",314.40390000000002,0.24339064953651199,0.18121344374989801,0.12543107263153799,0.82368099147738705]
["total (sum)",9087.7999999999993,"±",1515.1780000000001,8771,"±",1496.048,8845.4,"±",1368.0730000000001,0.98724325655437195,0.88070656038018802,0.97187183598859905,0.90856231922633701]
["acyl_C4",2900,"±",388.58718455450901,1840,"±",220.45407685048599,2180,"±",128.062484748657,4.47830907172133E-2,1.6243473331853001E-2,0.387884533674832,8.2097433064942396E-2,6,"Yes"]
["acyl_C5",2776,"±",978.87997221314095,2358,"±",521.11802885718703,3500,"±",987.92712281827801,0.64552513710961001,0.73628557256481297,0.36489804777506801,0.56157619477079102]
["acyl_C5:1",333.2,"±",74.901535364770695,292,"±",42.941821107167797,240,"±",42.190046219457997,0.51179597938491495,0.60907863621506297,0.52001908976261801,0.257872800783564]
["acyl_C6",1272,"±",465.39660505852402,1700,"±",496.99094559156703,1196,"±",287.51695602172799,0.675467570933874,0.49172967980808802,0.41993782377065803,0.90186579985408]
["acyl_C8",60.2,"±",16.481504785668101,69.2,"±",12.2653984851696,73,"±",14.8391374412396,0.81994120790060598,0.67132758134470105,0.85736243879125995,0.54775775256725501]
["acyl_C8:1",27.6,"±",5.97996655509042,72.400000000000006,"±",17.281782315490499,39.200000000000003,"±",6.5833122362531196,3.9221491372923301E-2,1.53732431976456E-2,5.8360849578417799E-2,0.47883172663905699,11,"Yes"]
["acyl_C10",42.2,"±",13.0590964465387,48,"±",9.1487704091861399,46.2,"±",5.3422841556772296,0.91139471033018404,0.68018529623053103,0.89787054443527403,0.77577539016008001]
["acyl_C10:1",38.200000000000003,"±",4.72652091923859,46.2,"±",5.80861429258304,46,"±",8.4734880657259399,0.62536549613844605,0.403245228418385,0.98307455218309903,0.414764205406291]
["acyl_C12",94.2,"±",20.003499693803601,132,"±",38.247875758007801,103.4,"±",11.3207773584679,0.57200567032701599,0.31996632512554801,0.447690611480275,0.80492134963489204]
["acyl_C12:1",65.2,"±",8.3390646957557504,57.2,"±",7.9523581408284203,74.599999999999994,"±",9.0421236443658497,0.37655236649351098,0.51620220503033298,0.171344832579754,0.44711402288140101]
["acyl_C14",58.6,"±",7.9536155300592704,92,"±",23.274449510138801,59.6,"±",6.8014704292527801,0.23036684022058099,0.13491921767500401,0.14591574951011099,0.96251100187819305]
["acyl_C14:1",61.8,"±",19.726631744928,104.8,"±",23.343949965676298,76.2,"±",10.9288608738514,0.29253074258776501,0.130651055482049,0.30172551448033902,0.59683214558460196]
["acyl_C16",436,"±",46.3249392876019,572,"±",114.603664862866,386,"±",32.341923257592498,0.22340703750902299,0.21682483066189101,9.9901836913352998E-2,0.640365648444295]
["acyl_C18",47.6,"±",6.0712436946642203,68.2,"±",17.7606306194347,36,"±",3.53553390593274,0.15491886900219001,0.21115506740815601,6.1250873666935199E-2,0.47129107254143598]
["acyl_C18:1",200,"±",27.018512172212599,418,"±",104.134528375559,256,"±",81.890170350293005,0.16476741634370301,7.1758368599761799E-2,0.16796043538721001,0.62115345625039498,24,"Yes"]
["acyl_C18:2",432,"±",99.267315869827002,442,"±",97.693397934558504,348,"±",123.830529353629,0.79778748473144101,0.94868493688071898,0.548288327023153,0.591062988270733]
["acyl_C20:4",243,"±",69.457900918470003,459,"±",152.039468559976,185.2,"±",89.370241132045706,0.21715138564878,0.18809892528255701,0.102252437680004,0.71531011566362201]
["Data represented as mean ± SEM. ANOVA with fixed effect for maternal diet. P < 0.05 by Student's t-test."]
["VIP rank from PLS-DA with metabolites, acylcarnitines, and bile acids."]
["Features submitted for pathway analysis are indicated ('Yes') to include the top 25 features from VIP rank with P < 0.15 in CON vs OB-WSD or features with P < 0.05 by t-test in CON vs OB-WSD. "]
["PLS-DA, partial least squares discriminant analysis; VIP, variable importance in projection."]

{"sheet":"Table S4","index":3,"n_rows":15,"n_cols":17,"rows_kept":15,"cut":false,"hidden":false,"merged":[[2,3,2,5],[2,6,2,8],[2,9,2,11],[1,13,1,15]]}
["Table S4. Bile acid concentrations in the fetal liver"]
[{"$nulls":13},"P-value"]
["Bile acid (fmol/mg tissue)","Symbol","Type","CON",null,null,"OB-WSD",null,null,"OB-DR",null,null,"ANOVA","CON vs OB-WSD","OB-WSD vs OB-DR","CON vs OB-DR","VIP Rank"]
["cholic acid","CA","primary",53.4,"±",10.8563345563777,32.200000000000003,"±",9.7693397934558508,159.4,"±",96.640364237724199,0.27101630193086901,0.208795188256619,0.13693492001041599,0.79501325592239402]
["chenodeoxycholic acid","CDCA","primary",68,"±",15.709869509324401,41.6,"±",9.7036075765665597,117,"±",22.618576436195099,2.4267116925829099E-2,6.2283914283098901E-2,8.1801269657922598E-3,0.289843573181227]
["deoxycholic acid","DCA","secondary",21,"±",1.30384048104053,17.12,"±",2.25264289224901,32.799999999999997,"±",5.6338264084013101,2.3702083998887801E-2,3.8159381356277902E-2,9.2856586323462591E-3,0.45864420393177702]
["ursodeoxycholic acid","UDCA","tertiary",66.8,"±",9.3509357820487704,70.400000000000006,"±",25.126878039263101,118,"±",38.166739446801103,0.35624936539975399,0.20367497215566299,0.235165413123196,0.92624845194271899]
["taurocholic acid","TCA","conjugated",91000,"±",20639.767440550298,58200,"±",5489.9908925243199,63600,"±",7947.3265945222101,0.20929399011872901,0.166594988737717,0.77660069414191901,0.103353575470776]
["taurolithocholic acid","TLCA","conjugated",2180,"±",303.97368307141301,3300,"±",791.83331579316598,2740,"±",492.54441424099002,0.40414358167598602,0.49771287528742503,0.49771287528742503,0.18725901336005801]
["taurochenodeoxycholic acid","TCDCA","conjugated",60400,"±",11258.774356030101,49800,"±",2107.1307505705499,40800,"±",6995.7129729570797,0.241549403169037,9.8944754680071897E-2,0.427510726136968,0.35250139899606098]
["glycocholic acid","GCA","conjugated",71800,"±",14578.7516612363,52400,"±",8600,53000,"±",10029.9551344959,0.41646755450672401,0.26460343597756902,0.97082045145620299,0.250451045992166]
["glycochenodeoxycholic acid","GCDCA","conjugated",5700,"±",781.02496759066503,6520,"±",611.06464469808805,6200,"±",1628.1891781976699,0.86991897172866095,0.75357117792790296,0.840565813803548,0.60793544407235001]
["Data represented as mean ± SEM. ANOVA with fixed effect for maternal diet. P < 0.05 by Student's t-test."]
["VIP rank from PLS-DA with metabolites, acylcarnitines, and bile acids (no bile acid species made the top 25 list)."]
["PLS-DA, partial least squares discriminant analysis; VIP, variable importance in projection."]

{"sheet":"Table S5","index":4,"n_rows":125,"n_cols":19,"rows_kept":125,"cut":false,"hidden":false,"merged":[[123,0,123,12],[2,10,2,12],[2,4,2,6],[2,7,2,9],[1,14,1,16],[1,4,1,6],[1,7,1,9],[1,10,1,12]]}
["Table S5. Metabolite concentrations in the fetal umbilical artery"]
[{"$nulls":14},"P-value"]
["Metabolite","Compound ID","KEGG ID","Pathway","CON",null,null,"OB-WSD",null,null,"OB-DR",null,null,"ANOVA","CON vs OB-WSD","OB-WSD vs OB-DR","CON vs OB-DR","VIP Rank","Pathway"]
["L-Alanine","HMDB0000161","C00041","Amino acids",14155996.800000001,"±",1750548.8473636601,18239622.857142899,"±",1378017.0002885901,14943286,"±",1267059.5775282199,0.13389804116918,6.7330896635741294E-2,0.13174787115653999,0.72864299820985501]
["L-Arginine","HMDB0000517","C00062","Amino acids",4503081.4000000004,"±",171084.284946222,5063459.7142857099,"±",461984.00004518399,4550146,"±",464411.77047142101,0.56128424156062096,0.35249516533816999,0.39320638331594698,0.94144583101358603]
["L-Asparagine","HMDB0000168","C00152","Amino acids",658540.72,"±",64779.591502365904,901516.6,"±",99875.443995163107,759616.8,"±",60735.642427630599,0.15207897216539101,6.0171594984812102E-2,0.25229071159706701,0.44414628557076202]
["L-Aspartic acid (Aspartate)","HMDB0000191","C00049","Amino acids",190679.58,"±",17020.661738557599,386709.71428571403,"±",50285.2724247199,246893.84,"±",22442.95369731,7.3912723517696802E-3,2.9842095396511899E-3,2.27978197775906E-2,0.35730892773566902,24,"Yes"]
["L-Cysteine","HMDB0000574","C00097","Amino acids",352546.8,"±",40706.321606625199,401639.64285714302,"±",28642.946474064502,303991.82,"±",15743.464165913399,0.101397377509805,0.26362623091519899,3.6197134944166001E-2,0.30427285282744199]
["L-Glutamic acid (Glutamate)","HMDB0000148","C00025","Amino acids",1147993.98,"±",53116.887008750797,2815649.7142857099,"±",495805.60904036899,1504865,"±",87467.213550564207,1.1306154319216799E-2,5.4395593510215001E-3,2.17786471961143E-2,0.52590049568571595,null,"Yes"]
["L-Glutamine","HMDB0000641","C00064","Amino acids",9345501,"±",659181.19076806202,9478515.5714285709,"±",806219.11235150602,10244349.800000001,"±",257407.85568051299,0.64276099044173796,0.89131821561206304,0.436445851664166,0.39869793166829198]
["Glycine","HMDB0000123","C00037","Amino acids",5340769.2,"±",208417.02379277899,4864739.57142857,"±",253988.00583959499,4789066.4000000004,"±",218974.90892008599,0.27253102651599997,0.17519939891441,0.82369262442083602,0.14772757570904199,13,"No"]
["L-Histidine","HMDB0000177","C00135","Amino acids",7349700,"±",2830013.5205795001,5466589.42857143,"±",1881204.02016809,1987918.8,"±",38265.273221812997,0.22035004629333499,0.50469856258621404,0.226562433547155,9.2623515148633997E-2]
["L-Leucine","HMDB0000687","C00123","Amino acids",94302936,"±",8553425.8655684907,140948891.42857099,"±",33579754.915403001,133142200,"±",10840831.7108975,0.416362709984199,0.208775843768509,0.82864714351861302,0.32698398096157599]
["L-Lysine","HMDB0000182","C00047","Amino acids",9048178.4000000004,"±",871733.16742622596,11254429.857142899,"±",1421279.40946416,9410088,"±",773241.56114948995,0.367513631478461,0.20408682691861799,0.28418978057614402,0.84258061286958597]
["L-Methionine","HMDB0000696","C00073","Amino acids",11336966.800000001,"±",1908171.7406669201,9586790.5714285709,"±",861118.427740062,9844173.1999999993,"±",1453702.3916110999,0.63732549296552898,0.37071411946762101,0.89375084546522898,0.47723856656532598]
["L-Phenylalanine","HMDB0000159","C00079","Amino acids",23345100,"±",2546770.1083038501,24876387.142857101,"±",2336552.6975681302,21467634,"±",1318998.6722684701,0.56068952117314996,0.62959916951244199,0.29088481799300397,0.58452397369297304]
["L-Proline","HMDB0000162","C00148","Amino acids",109093836,"±",7614751.5085093901,165155600,"±",26007506.126125898,105354496,"±",5895056.20460195,7.1473727843320095E-2,5.8570741031323002E-2,4.5384792004586103E-2,0.90061719417508801]
["L-Serine","HMDB0000187","C00065","Amino acids",1463504.8,"±",143892.71297685601,1300366.7142857099,"±",91430.743420183106,1306202.2,"±",72903.447034690995,0.49804818759893899,0.28293064371764198,0.96870192349114503,0.33574969937826699]
["L-Threonine","HMDB0000167","C00188","Amino acids",3907250.8,"±",554815.11136471399,3416978.8571428601,"±",374305.55932950397,3588180.6,"±",370605.28732798703,0.72181968597137602,0.428890217061908,0.78020082713068595,0.63112115979671901]
["L-Tryptophan","HMDB0000929","C00078","Amino acids",16957450,"±",1515534.3731370801,15174928.571428601,"±",865180.684909306,16025988,"±",1052877.4254176,0.53485373555841598,0.272755048432063,0.59428120747048796,0.58944257172990899,12,"No"]
["L-Tyrosine","HMDB0000158","C00082","Amino acids",11871726.199999999,"±",1503262.7563870701,8537158.2857142892,"±",960327.66909273295,9651649.1999999993,"±",1853107.40100153,0.25693203779190898,0.106547732464426,0.57343565701060395,0.30569142158496099]
["L-Valine","HMDB0000883","C00183","Amino acids",165179120,"±",7986694.1027811999,180598957.14285699,"±",16645215.552479399,190585800,"±",16451837.491326001,0.54802738337904899,0.47868722349746901,0.64460471994192303,0.28556384403204399]
["L-Cystine","HMDB0000192","C00491","Amino acids",370811.28,"±",43045.099469154397,395276.75714285701,"±",52607.559724660699,338813.82,"±",22784.698521297101,0.67915230767004298,0.70499070287397103,0.387562064033802,0.64705552465972305]
["Adenine","HMDB0000034","C00147","Nucleotides",222959.66,"±",20640.027079478401,211075.41428571401,"±",10393.714715690299,252193.96,"±",25691.964394701299,0.293324119551373,0.64654002008418499,0.127216017904378,0.30389466288448103,20,"No"]
["Guanosine monophosphate","HMDB0001397","C00144","Nucleotides",12036.638199999999,"±",3933.6522867942799,4102.55,"±",3127.5546262589501,3249.4533000000001,"±",1790.95971401005,0.14953712241021699,9.1779178845886794E-2,0.84847415987337105,8.4609157367160695E-2,8,"Yes"]
["Guanosine","HMDB0000133","C00387","Nucleotides",130991.306,"±",17500.024212252301,69371.002857142899,"±",12141.9760816545,98075.846000000005,"±",14461.5278853134,2.7240340356866101E-2,8.3886946948983805E-3,0.17522190639875099,0.151772461199566,14,"Yes"]
["Guanine","HMDB0000132","C00242","Nucleotides",293461.52,"±",19372.362581249599,941687.3,"±",145148.558319612,489418.64,"±",26497.7085714897,1.72658089838235E-3,6.6493212281227003E-4,8.9008235143776208E-3,0.24347187971651099,4,"Yes"]
["Cytidine","HMDB0000089","C00475","Nucleotides",133338.16,"±",21039.381127557001,41339.285714285703,"±",13112.508368999301,106118.598,"±",28658.8247615199,1.42469584621767E-2,5.6876996887149202E-3,3.7625877774790803E-2,0.38682783247738001,5,"Yes"]
["Thymidine","HMDB0000273","C00214","Nucleotides",66614.982000000004,"±",3166.3929948703499,20139.516857142899,"±",6992.7399574682204,63052.343999999997,"±",15322.334307622499,4.1641294060310204E-3,3.1228488292214E-3,5.3749520391286202E-3,0.80407716404387897,1,"Yes"]
["Uracil","HMDB0000300","C00106","Nucleotides",77312.092000000004,"±",2300.91879356356,118403.83857142901,"±",12546.495823318,66626.618000000002,"±",5587.1541095171197,3.44480883285859E-3,8.4036708229689693E-3,1.7281094876881501E-3,0.47282910405727802,null,"Yes"]
["Inosine","HMDB0000195","C00294","Nucleotides",401765.24,"±",72708.259303153405,141471.17857142899,"±",18462.503312462199,203962.04,"±",31014.187337001102,1.7712127979061E-3,5.4229287317501395E-4,0.30273143038053901,7.2979017768729998E-3,6,"Yes"]
["Hypoxanthine","HMDB0000157","C00262","Nucleotides",5114018.5999999996,"±",694411.40718263004,6702925.1428571399,"±",778157.67133915296,5090336.5999999996,"±",477241.87170130003,0.19157199466615099,0.12909112131960801,0.123934031910509,0.98255846554119497]
["Allantoic acid","HMDB0001209","C00499","Nucleotides",263273.21999999997,"±",31238.046177656499,313445.92857142899,"±",35222.329098454902,341461.44,"±",27015.330424919801,0.30816460401330797,0.29332075907947502,0.55183799715308501,0.13749925144790301]
["(S)(+)-Allantoin","METPA0276","C02350","Nucleotides",100668.54,"±",2967.5431848736398,121220.975714286,"±",7784.1366192165397,107752.408,"±",8907.9430594376809,0.15456887494552299,6.5178259155682802E-2,0.21087004676742099,0.53345190825708599]
["5-Hydroxyisourate","HMDB0030097","C11821","Nucleotides",121071.462,"±",10681.828525278101,151263.29,"±",25216.197955505399,131702.76,"±",10805.662176497999,0.54573855752082701,0.29408000847370702,0.49162346230066201,0.72760590022327698]
["Urate","HMDB0000289","C00366","Nucleotides",959428.04,"±",133790.412078275,3022873.7142857099,"±",651518.80063052196,1949738.4,"±",521267.45766128501,5.0359105831242097E-2,1.68213053034207E-2,0.180087221953634,0.247996719786582,11,"Yes"]
["Adenosine phosphosulfate","HMDB0001003","C00224","Nucleotides",1359.97506,"±",441.27786700915999,2696.8402857142901,"±",620.77550312920698,1720.6451999999999,"±",344.85899139349698,0.19864945970226899,9.3008543622202802E-2,0.209217060986959,0.65942217914531898]
["Dihydrothymine","HMDB0000079","C00906","Nucleotides",886762.36,"±",30661.063680906402,1139368.5,"±",179795.394259283,1142286.6599999999,"±",99570.808547463399,0.388991722605534,0.21920758022321499,0.98835395525477099,0.248315871964853]
["4-Pyridoxic acid","HMDB0000017","C00847","Nucleotides",108245.538,"±",19794.553252445599,49016.955285714299,"±",9312.5575810016999,70859.566000000006,"±",18775.174299325899,4.5747367963568597E-2,1.47368280269898E-2,0.32257477786850097,0.12648443089800099,10,"Yes"]
["Nicotinamide","HMDB0001406","C00153","Nucleotides",1060853.1200000001,"±",107682.70127217,1631239.1428571399,"±",103516.20578933699,1294923.8,"±",55851.839158974901,2.7563419885260399E-3,8.4896917583587297E-4,2.59159719659014E-2,0.13079460071972601,null,"Yes"]
["Phosphate","HMDB0001429","C00009","Phosphates",13676343.4,"±",1082802.77504103,14767377.142857101,"±",1380061.0059491899,15840824,"±",2151402.6129588098,0.66613242500192205,0.62623487609384998,0.631761597199611,0.37586897098681898]
["Pyrophosphate","HMDB0000250","C00013","Phosphates",354758.68,"±",69705.132970868101,392622.67142857099,"±",60800.665865474701,492947.12,"±",146617.493838036,0.59943933483383005,0.77389312718248204,0.45061741971876601,0.33912763239472998]
["D-Glucose","HMDB0000122","C00031","Glycolysis",497677.1,"±",24116.731554690399,453549.01428571402,"±",62187.294726343898,511645.48,"±",43820.019250399702,0.69696545379267205,0.55050118614231902,0.43404951177489598,0.860283927829123]
["Glucose 6-phosphate","HMDB0001401","C00092","Glycolysis",90605.388000000006,"±",9496.7000451616896,122051.157142857,"±",25084.224018849,118216.32799999999,"±",13999.759635763499,0.51599453837972897,0.28128885747146398,0.89324135127216897,0.37771322174636901]
["Pyruvate","HMDB0000243","C00022","Glycolysis",890419.7,"±",66647.385136237703,1753452.0857142899,"±",345282.42762139201,1073290.22,"±",137579.47703272599,6.9688558934644707E-2,3.3514104250121697E-2,8.4390013582482395E-2,0.65091236885501402,null,"Yes"]
["Lactate","HMDB0000190","C00186","Glycolysis",18458568,"±",842513.55810693,41340517.142857097,"±",4755118.5455593504,25232018,"±",2691487.2510591601,1.57154189391783E-3,6.1513541287192995E-4,7.9683306576564007E-3,0.24875819511425601,3,"Yes"]
["Sorbitol","HMDB0000247","C00794","Other sugars",20369.341400000001,"±",4280.12058470798,20997.68,"±",3802.0248883694799,22631.592000000001,"±",839.05808690697904,0.90720809405377301,0.900152104714947,0.74463314247067802,0.67667140933384995]
["D-Ribose","HMDB0000283","C00121","Other sugars",118893.592,"±",9014.2847224981706,125429.024285714,"±",7129.3373555344097,115143.302,"±",5941.2075049945897,0.61028238431308501,0.54207108821439298,0.34203721818225702,0.74480274905753696]
["D-Arabitol","HMDB0000568","C01904","Other sugars",21523.031999999999,"±",3233.0631259247002,24338.177142857101,"±",1742.7270832338399,25083.49,"±",2866.02759614767,0.61435800519566297,0.43496222769084097,0.83454985860485298,0.36257645994923199]
["Citrate","HMDB0000094","C00158","TCA cycle",971765.36,"±",78459.498301573403,1234277.6714285701,"±",91654.774556657794,1351550,"±",141919.92268106699,7.9787684054200905E-2,9.5189769568417598E-2,0.43741030670025,3.1057869849845699E-2]
["alpha-Ketoglutarate","HMDB0000208","C00026","TCA cycle",161551.68799999999,"±",21099.425776142401,176986.657142857,"±",14528.6986170206,199028.56,"±",17047.613644220099,0.37410029359507802,0.53106718783305895,0.37456241957646502,0.17079615711618101]
["2-Keto-glutaramic acid","HMDB0001552","C00940","TCA cycle",76940.683999999994,"±",4794.0991592608898,67024.8342857143,"±",4835.8558832157796,74523.423999999999,"±",9595.9124051767994,0.51471117761454499,0.28746145211212298,0.417077336736283,0.80654569032094403,19,"No"]
["Succinate","HMDB0000254","C00042","TCA cycle",350851.28,"±",42680.717853784998,1480988.9,"±",553464.12261663098,555412.07999999996,"±",51333.436952160097,0.12632070023330599,6.4526023405962404E-2,0.12259028372729,0.74168002610633199]
["Fumaric acid","HMDB0000134","C00122","TCA cycle",112599.014,"±",11355.765686694,119907.50714285699,"±",14874.8314263054,118137.196,"±",11787.699112901801,0.926118792223253,0.70541856934143199,0.92686290021591999,0.79058159438198095]
["(R)-Malate","METPA0049","C00497","TCA cycle",317344.7,"±",32395.184590661,895190.7,"±",145065.58046795501,566755.14,"±",61748.910430878001,7.2791680148320296E-3,2.2496264004985399E-3,5.2467917241056899E-2,0.15848947928573701,7,"Yes"]
["Oxaloacetate","HMDB0000223","C00036","TCA cycle",466902.9,"±",20244.1639610778,421138.78571428597,"±",22971.525509571002,462788.46,"±",38538.169525816898,0.42070263158351501,0.25260531188268598,0.29584163162173099,0.92229177413487395]
["2-Hydroxyglutarate","HMDB0000694","C03196","Alternative Carboxylic acids",148407.12400000001,"±",25260.777057580301,354457.85714285698,"±",80075.388601372906,221577.4,"±",39623.0249394844,8.5923527585421794E-2,3.3852646543668201E-2,0.15161900407336601,0.45228272319294599,null,"Yes"]
["Pentose phosphates (isobars)","NA","NA","Pentose Phosphate Pathway",15552.250400000001,"±",4541.9888151159203,12314.6525714286,"±",1919.07315678289,12289.697399999999,"±",2313.43289952943,0.68643584910399003,0.43892263334994902,0.995186888184181,0.469593820039654]
["Pyroglutamic acid","HMDB0000267","C01879","GSH homeostasis",4849905,"±",262595.90957172198,5455156.7142857099,"±",417519.99664257403,5523350.4000000004,"±",185320.59102366399,0.37047371916092398,0.227459655070996,0.88892903315190197,0.214481377164222]
["S-Glutathionyl-L-cysteine","METPA0607","C05526","GSH homeostasis",6178.9748,"±",1778.01628050402,10872.0078571429,"±",1664.7051214570299,13114.67,"±",5236.1561876591904,0.32593077311489499,0.28508141215420901,0.60364127955561098,0.15057361282592999]
["Cysteinylglycine","HMDB0000078","C01419","GSH homeostasis",119133.43399999999,"±",10653.820552212999,90614.961428571405,"±",12951.415635933499,130137.72199999999,"±",15978.9468124168,0.121449912878593,0.15139637739852599,5.4028572908347498E-2,0.59626571554232599,18,"Yes"]
["Ascorbate","HMDB0000044","C00072","GSH homeostasis",4042831.2,"±",581225.58233747794,2617356.8571428601,"±",460677.16939907498,3618990.6,"±",425745.09822199901,0.13055954059988001,5.7037946715962101E-2,0.16714747729340201,0.57715714495908399,15,"Yes"]
["Dehydroascorbate","HMDB0001264","C00425","GSH homeostasis",863480.54,"±",114455.27677457999,672573.88571428601,"±",84241.108629808805,884580.3,"±",68205.239075440506,0.20102114777760599,0.15340010361845199,0.11584547840587001,0.87944964264693803]
["5-L-Glutamyl-L-alanine","HMDB0006248","C03740","Gamma-glutamyls",82969.165999999997,"±",8097.2430775089097,77157.147142857197,"±",14189.935068114601,78112.702000000005,"±",6781.2818800352197,0.93318317769097203,0.724773860111947,0.95373658064911904,0.78514165519581103]
["4-(Glutamylamino) butanoate","HMDB0012161","C15767","Gamma-glutamyls",37204.950199999999,"±",11982.7550205275,44711.935857142897,"±",16728.0502029952,93805.341400000005,"±",31202.577549039801,0.170883508892088,0.79880923005457305,0.11143488587931399,9.12559405209451E-2]
["L-Homocysteine","HMDB0000742","C00155","Serine biosynthesis and one-carbon metabolism",176233.8,"±",15808.7504983158,169545.685714286,"±",8557.0166582037,163449.13,"±",30909.871902102699,0.90074143431473497,0.79923765274120595,0.81662749565175596,0.65345023430577698]
["L-Cystathionine","HMDB0000099","C02291","Serine biosynthesis and one-carbon metabolism",9043.3150000000005,"±",2551.4100922279799,11639.571714285699,"±",3136.7946369131801,8673.7687999999998,"±",2817.9109164220499,0.73073477109921203,0.54135922722664098,0.48627016787289901,0.93541729066801904]
["Dimethylglycine","HMDB0000092","C01026","Serine biosynthesis and one-carbon metabolism",4311980.8,"±",430811.53541814501,5540955.8571428601,"±",1051251.6352290399,5651398.2000000002,"±",421297.148119519,0.48916516099038498,0.30189455565600798,0.92462622878721301,0.29772227586570799]
["Phosphohydroxypyruvic acid","HMDB0001024","C03232","Serine biosynthesis and one-carbon metabolism",5319.0691999999999,"±",1150.3567321268399,10706.3094285714,"±",2280.00673178438,8113.5998,"±",845.103787638737,0.137013258934083,5.0567980871375297E-2,0.32079584879008299,0.321783033880092,null,"Yes"]
["L-Homoserine","HMDB0000719","C00263","Serine biosynthesis and one-carbon metabolism",967230,"±",59534.984237631201,1024579.75714286,"±",42713.073468329203,930064.96,"±",39857.095176901697,0.37211132974341299,0.40135315164752,0.175677198297644,0.611681135793405]
["Ornithine","HMDB0000214","C00077","Urea cycle",911231.74,"±",47714.432167056097,1135791.7142857099,"±",104449.72149678699,1048730.6399999999,"±",59490.5349393465,0.20250682326901301,7.9194295615407598E-2,0.47508189136216,0.30133419751406798]
["Citrulline","HMDB0000904","C00327","Urea cycle",990650.16,"±",86648.285703028203,1060280.1571428599,"±",77933.537547398897,971242.54,"±",70469.250815661406,0.69557127925649798,0.54114005033215196,0.43652779522260499,0.87389978538636404]
["Putrescine","HMDB0001414","C00134","Polyamines",201287.67999999999,"±",22071.835244297199,297955.14285714302,"±",31663.670058578198,235721.94,"±",18218.340628515001,5.98939029322509E-2,2.2932082427692901E-2,0.122367911883675,0.41376088880350598,null,"Yes"]
["Spermidine","HMDB0001257","C00315","Polyamines",57979.93,"±",4271.6099322293003,83910.437142857103,"±",9239.9409293975405,58725.17,"±",9417.2131772690609,6.73859673254215E-2,4.5949460340415797E-2,5.1671333810157302E-2,0.95435508939771196,null,"Yes"]
["Spermine","HMDB0001256","C00750","Polyamines",18858.767,"±",5115.6912348170499,33871.033428571398,"±",6553.9174205793597,30946.298999999999,"±",7389.5606862770301,0.27317743609581702,0.123174944300112,0.75399052694118696,0.24156051351609301]
["N-Acetyl-9-O-acetylneuraminic acid","HMDB0000794",null,"Aminosugars",14245.8742,"±",2245.2677344498702,29610.451428571399,"±",2788.3864186388601,19259.542000000001,"±",2503.6058051606301,2.5625001798088298E-3,9.3297655701645897E-4,1.3812136538333601E-2,0.227700783749538,null,"Yes"]
["N-Glycolylneuraminic acid","HMDB0000833","C03410","Aminosugars",6773.0883999999996,"±",1487.3143541131301,9228.4092857142805,"±",2085.96817613237,7115.5385999999999,"±",1795.79536015807,0.60392260512739804,0.37367305283263103,0.44225205762415298,0.90722769955900595]
["Carnosine","HMDB0000033","C00386","Arginine and proline metabolism",127323.686,"±",13614.589333747699,180645.771428571,"±",15254.027386448801,161340.34,"±",9466.5671398664908,4.7597449560180298E-2,1.5426312720182999E-2,0.33510429012188397,0.12571687038837201,null,"Yes"]
["5-Guanidino-2-oxopentanoate","HMDB0004225","C03771","Arginine and proline metabolism",135330.85399999999,"±",23861.117782109399,127156.225714286,"±",19759.586392605801,175317.66399999999,"±",30963.806539692399,0.36537290568688302,0.81301046000589905,0.17744442569702301,0.293418084857207]
["Creatine","HMDB0000064","C00300","Arginine and proline metabolism",79187192,"±",4100710.2296155998,108298051.428571,"±",19131965.9652493,112930090,"±",6677565.5649795001,0.265452692886815,0.170815671559778,0.82162867609367196,0.14360791773803799]
["Creatinine","HMDB0000562","C00791","Arginine and proline metabolism",32150678,"±",2135965.7290588701,44630904.285714298,"±",3229197.2327594399,38518602,"±",1145559.39934776,1.4936219166029399E-2,4.4541496985734197E-3,0.11970026737279001,0.13225465268202999,22,"Yes"]
["4-Acetamidobutanoic acid","HMDB0003681","C02946","Arginine and proline metabolism",319216.64000000001,"±",51996.419818085596,392479.2,"±",46441.125565781302,378348.5,"±",31603.5055937629,0.51038239954227205,0.26789890926167798,0.82710558255378197,0.40311635016029201]
["N-Acetylornithine","HMDB0003357","C00437","Arginine and proline metabolism",499670.66,"±",68393.818932565802,147795.774285714,"±",20118.187721071699,666409.31999999995,"±",89944.341012602905,4.9689256413942303E-5,7.21534904919112E-4,1.7978207816861799E-5,7.9616079934848399E-2,2,"Yes"]
["N-Succinyl-L-citrulline","NA","C18048","Arginine and proline metabolism",166476.1,"±",10509.3139446398,149932.5,"±",8011.2316958606198,200161.26,"±",19856.554931573599,4.0567354556857102E-2,0.36575595348356799,1.3155902163626399E-2,9.9858749506565994E-2,21,"No"]
["Guanidoacetic acid","HMDB0000128","C00581","Arginine and proline metabolism",336656.84,"±",55260.924596342003,365541.88571428601,"±",44007.708039747202,359893.08,"±",42404.766525821098,0.90445570940206799,0.66875719629055497,0.93310136588527504,0.74962932841395202]
["4-Hydroxyproline","HMDB0000725","C01157","Arginine and proline metabolism",4202826.8,"±",166480.286431277,4896241.7142857099,"±",380965.74855870102,4398985.4000000004,"±",380267.29621012602,0.34743773800250199,0.173408344790177,0.32108987899520602,0.71278422015104403]
["Aminofructose 6-phosphate","NA","NA","Arginine and proline metabolism",9060.3960000000006,"±",5263.7839441820697,11170.842000000001,"±",3591.6011172687699,11954.921899999999,"±",4511.37204158036,0.90015088806555899,0.73311984309197697,0.89900752503687797,0.66544697268116904]
["Pantothenol","HMDB0004231","C05944","Panthothenate metabolism",958888.12,"±",155119.71211442901,999548.81428571395,"±",114026.879435875,1002353.06,"±",143487.55798923,0.97036359772877101,0.83165315250628802,0.98829284908284198,0.83336354712156702]
["Dihydrouracil","HMDB0000076","C00429","Panthothenate metabolism",180331.04,"±",10022.4183469161,299710.54285714298,"±",35220.526637668198,219487.76,"±",20282.314125528199,2.25079732154887E-2,8.5579809410399506E-3,5.9229318149957501E-2,0.36921685771166102,25,"Yes"]
["Taurine","HMDB0000251","C00245","Sulfur metabolism",1740059.4,"±",90314.348993723004,2115676.7142857099,"±",167570.72696522201,2170326.4,"±",80226.391640531903,0.10143542609435301,6.7848955083145104E-2,0.77763382161443995,5.4472077986702602E-2]
["3-Mercaptopyruvic acid","HMDB0001368","C00957","Sulfur metabolism",19995.898000000001,"±",2330.96694232544,17120.719571428599,"±",1650.3420155582501,17296.227999999999,"±",2243.7303528463499,0.561756655570122,0.324527620125728,0.95118057719397098,0.38972431927071899]
["Cysteic acid","HMDB0002757","C00506","Sulfur metabolism",7678.5092000000004,"±",2186.6822186376598,15147.743857142899,"±",4571.09570521367,12510.3604,"±",2267.6037380841999,0.37148853759441902,0.16772070041999601,0.61543030262839804,0.39822031679469699]
["L-Methionine S-oxide","METPA0344","C02989","Sulfur metabolism",953799.38,"±",102350.66906122499,974932.557142857,"±",52614.655871456896,907001.04,"±",82385.754252453102,0.81554855355589395,0.84529285083681704,0.53315945425306699,0.68977876804481897]
["5-Hydroxyindoleacetic acid","HMDB0000763","C05635","Indole and Tryptophan",226799.2,"±",22390.571083449398,253175.8,"±",29941.441668784701,264787.36,"±",62783.934664073102,0.81149054592098202,0.64290185295115199,0.83776080229499295,0.53767040603646798]
["3-Methyleneoxindole","NA","NA","Indole and Tryptophan",449222.22,"±",28615.4174435286,424065.45714285702,"±",20593.7299494734,481145.96,"±",59543.720122617502,0.54533742004973695,0.62768218309161194,0.27945944356411101,0.56944566058665702,16,"No"]
["Indole","HMDB0000738","C00463","Indole and Tryptophan",308150.03999999998,"±",21667.993180601701,290849.98571428598,"±",16340.386380310099,288776.62,"±",25755.046649276301,0.78732384290947499,0.55765421982614904,0.94362844350744701,0.54344769242638902,23,"No"]
["Indoleacetaldehyde","HMDB0001190","C00637","Indole and Tryptophan",186644.14600000001,"±",42138.177628444202,233195.61428571399,"±",21859.5625556308,135222.09,"±",24218.655950570399,8.6904276175869599E-2,0.27078724787132702,3.0106054057609299E-2,0.26053866174898799]
["Xanthurenic acid","HMDB0000881","C02470","Indole and Tryptophan",540071.72,"±",134411.29183123901,589750.942857143,"±",60864.710165935001,507001.02,"±",77222.912806461798,0.798461176133899,0.69662820771493705,0.51812714402847304,0.80978851023229803]
["L-Kynurenine","HMDB0000684","C00328","Indole and Tryptophan",1984735.6,"±",240382.34899106101,2153989.42857143,"±",233959.44944704499,2337190.2000000002,"±",510092.70639055403,0.78127205022490498,0.71870094609756296,0.69674543622305996,0.49019036953539802]
["N'-Formylkynurenine","HMDB0001200","C02406","Indole and Tryptophan",44649.139000000003,"±",13437.069114116,29166.8485714286,"±",9256.1103373005408,167905.139,"±",137614.769079552,0.34993168076707598,0.87574970536994101,0.175496587035716,0.26008533400573602]
["Serotonin","HMDB0000259","C00780","Signaling",77560.590500000006,"±",23292.9990094483,115292.658571429,"±",12099.3866395923,47248.936999999998,"±",10356.680284917,2.2311132286911999E-2,0.103322036381334,7.1990281096075701E-3,0.215924602750098]
["Inositol 1,2,3,5,6-pentakisphosphate","METPA0515","C04579","Inositol",13480.090200000001,"±",1524.0060299204999,14810.3304285714,"±",2225.6745078237,16114.422,"±",1336.34808097067,0.66601552548463605,0.62554996054511802,0.63230270568306701,0.37576896396478199]
["Glycerol 3-phosphate","HMDB0000126","C00093","Glycerophospholipid biosynthesis",25171.112000000001,"±",5549.6914802224801,50333.035714285703,"±",17251.595450184301,34021.83,"±",2588.7434520844299,0.379591785108504,0.18421393297666999,0.38052251018352701,0.65616308443181504]
["O-Phosphoethanolamine","HMDB0000224","C00346","Glycerophospholipid biosynthesis",60714.6,"±",6254.3414316888702,100617.77285714301,"±",15344.4367880726,78383.460000000006,"±",8615.8823819536901,9.9158590437643607E-2,3.6460775688659998E-2,0.218407345710736,0.35916499151787501,null,"Yes"]
["N-Methylethanolamine phosphate","METPA0145","C01210","Glycerophospholipid biosynthesis",1977255.2,"±",251751.310925167,2956762.2857142901,"±",386308.972443334,2548394.2000000002,"±",185159.666805274,0.128644478909514,4.6560744993271098E-2,0.37816737467777101,0.25826035062601099,null,"Yes"]
["L-Carnitine","HMDB0000062","C00318","Carnitine and fatty acid metabolsim",48732308,"±",4472961.8633019896,38960354.285714298,"±",9097508.8757006191,39416844,"±",5423310.3197056698,0.61179471275742503,0.36586111061742999,0.96579456613724002,0.423313173730957,17,"No"]
["Propionylcarnitine","HMDB0000824","C03017","Carnitine and fatty acid metabolsim",2035416.8,"±",220228.73405698,2743730.92857143,"±",737488.566937114,2561966.7999999998,"±",326016.28261612903,0.67318435049314895,0.389178071469653,0.82290125526569702,0.55057961719394699]
["Butanoyl-L-carnitine","NA","NA","Carnitine and fatty acid metabolsim",1000685.34,"±",75892.456368545594,1475331.6428571399,"±",335090.78412517102,1175612.8,"±",71896.350378444098,0.39818045906778898,0.19367325464549701,0.40311732685246998,0.64847208776940501]
["Isovalerylcarnitine","HMDB0000688",null,"Carnitine and fatty acid metabolsim",2496852.6,"±",252868.455238608,2986470.57142857,"±",380341.98823870899,2624438.4,"±",101859.042801609,0.49991485829682603,0.274325103726763,0.41433706300635798,0.78772201904924199]
["N5-Methyl-L-glutamine","NA","NA","Other",21685.713,"±",4831.6308705129804,24151.249285714301,"±",4197.3013319260999,31895.378000000001,"±",5465.8568087148096,0.35314052127403101,0.71626184118454805,0.26349063772569398,0.17693309316117101]
["Leucocyanidin","METPA1714","C05906","Other",12168.340200000001,"±",5246.9890838572401,6907.6814285714299,"±",2310.4717835158199,14017.4463,"±",5189.0203633783003,0.43451901653202402,0.369334346318825,0.23050359324744299,0.76719586709516796]
["2-Dehydro-3-deoxy-D-glucarate","METPA0444","C03921","Other",37179.315999999999,"±",3088.6861960072902,47508.145714285703,"±",3806.22352092243,47628.347999999998,"±",3176.5498289801799,0.10500882933367101,5.5752217620132501E-2,0.98097467813424599,7.1004991014935098E-2]
["Fe(III)dicitrate","NA","NA","Other",23617.874,"±",1588.9192035298699,21624.501428571399,"±",2852.1794746369201,18449.05,"±",2192.5431773627602,0.40030362216663601,0.57347280471985995,0.37403063342857501,0.18807944530533699]
["Succinyl sulfathiazole","NA","NA","Other",10094.854799999999,"±",2838.9472537818601,11602.1531428571,"±",1851.51159320223,8407.4032000000007,"±",2760.8063358403001,0.64227469076138399,0.65942116809496498,0.35610918132119601,0.64791057669640695]
["Protein glutamine","NA","NA","Other",3499.4764,"±",656.96539438821299,7302.8815714285702,"±",2181.7134970020302,39053.281999999999,"±",31774.7080043313,0.28852023392674198,0.86732037882475599,0.17736085008069599,0.16297544380016299]
["beta-D-Glucuronoside","NA","NA","Other",15626.744000000001,"±",1794.4922445683601,22643.445714285699,"±",2601.18532975684,21168.248,"±",600.38595299523797,8.4050788542484697E-2,3.2253199856055598E-2,0.62500829675921998,0.104136057826075,null,"Yes"]
["Protein 5-hydroxylysine","NA","NA","Other",141540.902,"±",27770.410247167802,351835.22714285698,"±",47441.538409116103,166815.242,"±",29773.934611251199,3.1957853024065998E-3,2.1083237719338702E-3,5.1718146825580104E-3,0.68196378412341596,9,"Yes"]
["trans-Homoaconitate","NA","NA","Other",6149.0523000000003,"±",2322.9819978426299,6322.9251428571397,"±",1975.46059300519,6700.9512000000004,"±",2399.9017982384398,0.98557128099852398,0.95575975045689898,0.904018576532156,0.87055405707923506]
["Carglumic acid","HMDB0015673","C05829","Other",37350.49,"±",2377.6373427186099,70332.474285714299,"±",16549.845524956501,328008.38,"±",239471.74265791199,0.23861067053017901,0.84757537191256305,0.14835322871991499,0.13245826985640299]
["2-Oxo-7-methylthioheptanoic acid","METPA1749","C17220","Other",1884139.2,"±",115065.52897605801,2152873.57142857,"±",238216.730692857,1926302.2,"±",145754.07839076099,0.56996069519092096,0.34391398187302402,0.42271381397454,0.88887713050809203]
["Homocitrulline","HMDB0000679","C02427","Other",125440.18,"±",20371.639418156799,140196.342857143,"±",10025.860967799499,166418.22,"±",8681.2434994878495,0.151949086934004,0.43926694177584902,0.179019324899265,5.9933230250908499E-2]
["Data represented as mean ± SEM. ANOVA with fixed effect for maternal diet. P < 0.05 by Student's t-test."]
["VIP rank from PLS-DA with all serum metabolites."]
["Features submitted for pathway analysis are indicated ('Yes') to include the top 25 features from VIP rank with P < 0.15 in CON vs OB-WSD or features with P < 0.05 by t-test in CON vs OB-WSD. Features from the top 25 VIP rank with P > 0.15 in CON vs OB-WSD were excluded from pathway analysis (indicated with 'No')."]
["KEGG, Kyoto Encyclopedia of Genes and Genomes; NA, not available; PLS-DA, partial least squares discriminant analysis; VIP, variable importance in projection."]