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{"sheet":"ComparativeNodeTable","index":0,"n_rows":145,"n_cols":4,"rows_kept":145,"cut":false,"hidden":false,"merged":[]}
["Pathway","q-value, Health to Disease","q-value, Disease to Treatment","q-value, Treatment to Health"]
["Acetylcholine binding and downstream events",0.00784799208938743,0.0246645427085786,0.0112331251194557]
["Activation of GABAB receptors",0.0376208367167512,"NA",0.0144339631879531]
["Activation of G protein gated Potassium channels",0.0237337247510071,"NA","NA"]
["Activation of Matrix Metalloproteinases",0.000140668465332274,"NA",0.000838519879485071]
["Activation of Nicotinic Acetylcholine Receptors",0.00784799208938743,0.0246645427085786,0.0112331251194557]
["Adenylate cyclase activating pathway","NA","NA",0.0402498807367913]
["alpha-linolenic acid (ALA) metabolism","NA","NA",0.0365703672364931]
["alpha-linolenic (omega3) and linoleic (omega6) acid metabolism","NA","NA",0.0365703672364931]
["Amine-derived hormones",0.0316202722180778,"NA","NA"]
["Amino acid and derivative metabolism","NA",0.00174378350805133,"NA"]
["Amino acid and oligopeptide SLC transporters",7.21126907629274E-006,0.00716966134245587,3.91573534880649E-005]
["Amino acid transport across the plasma membrane",0.00784799208938743,"NA",0.0260833127452661]
["Arachidonic acid metabolism",0.0139598173485465,0.000203288322520346,3.91573534880649E-005]
["Assembly of active LPL and LIPC lipase complexes",0.00527697891190387,0.00456208297778117,4.40736025889324E-005]
["Assembly of collagen fibrils and other multimeric structures",0.000836671752476167,0.0333019553952925,0.0166422653195945]
["A tetrasaccharide linker sequence is required for GAG synthesis",0.00167636912222516,"NA",0.0139133495851213]
["Bicarbonate transporters",0.0311592379652551,0.0493574999097662,"NA"]
["Binding and Uptake of Ligands by Scavenger Receptors",0.00200047027569677,"NA",0.000639828216736616]
["Biological oxidations","NA","NA",0.0191871382164318]
["BMAL1:CLOCK,NPAS2 activates circadian gene expression",0.0448464189825555,"NA","NA"]
["Carbohydrate metabolism","NA",0.0112744834319286,0.000263282814708549]
["Cardiac conduction",3.7813074191937E-005,0.00103039513033597,0.00209582064560715]
["Cell surface interactions at the vascular wall",2.77923872475348E-005,"NA",0.0004222155902819]
["Chemokine receptors bind chemokines",0.00193570700066974,0.00456208297778117,0.0470336878770755]
["Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex","NA","NA",0.0245269668127413]
["Chondroitin sulfate biosynthesis",0.00908513382020538,"NA",0.0148345432687508]
["Chondroitin sulfate/dermatan sulfate metabolism",0.0415173982015414,"NA","NA"]
["Chylomicron assembly",0.00967069904152016,0.0300902070193863,"NA"]
["Chylomicron remodeling",0.000140668465332274,0.00206506280268611,0.000254887713375038]
["Citric acid cycle (TCA cycle)","NA",0.00927263323836393,0.0412660191422741]
["Class A/1 (Rhodopsin-like receptors)",1.79971568532698E-010,6.40934635857644E-005,6.04282191770205E-006]
["Collagen biosynthesis and modifying enzymes",0.000182441569645044,0.0125614907045883,0.00402483033152859]
["Collagen chain trimerization",0.00396856917698799,"NA","NA"]
["Collagen degradation",0.00623065631581668,"NA",0.00082227209712581]
["Collagen formation",7.80475750394956E-005,0.00456208297778117,0.00129165803155606]
["Common Pathway of Fibrin Clot Formation",0.0168149051528836,"NA","NA"]
["Complement cascade",0.000136364353647748,0.00132729509088466,0.00079975905772859]
["Cyclin A/B1 associated events during G2/M transition","NA","NA",0.0152344974414206]
["Degradation of the extracellular matrix",6.91592464376387E-006,0.00927263323836393,2.18640661251412E-006]
["Dermatan sulfate biosynthesis",0.00483862926526472,"NA",0.0239856722412019]
["Dissolution of Fibrin Clot","NA","NA",0.0314368283045324]
["ECM proteoglycans",1.07512279062445E-005,0.0380121602552937,1.12164996831885E-005]
["Elastic fibre formation",0.0237337247510071,"NA","NA"]
["ERBB2 Activates PTK6 Signaling",0.0192641851432386,"NA","NA"]
["Extracellular matrix organization",5.69781227106522E-019,4.17326998628607E-008,1.19915379062904E-016]
["Fatty acid catabolism","NA",1.05738643792576E-005,2.53035874823671E-006]
["Fatty acid metabolism","NA",1.24907383026691E-005,1.26779459869489E-006]
["Fatty acid synthesis","NA",0.00191923265482453,0.00082227209712581]
["Fatty acyl-CoA biosynthesis","NA",0.0369325204088261,0.0319888293589855]
["FCGR activation",0.00500001928312884,"NA","NA"]
["Formation of Fibrin Clot (Clotting Cascade)",0.00140097637424496,0.0292307009725069,0.0046715447190667]
["GABA A receptor activation",0.00784799208938743,0.00796568271712622,"NA"]
["GABA B receptor activation",0.0376208367167512,"NA",0.0144339631879531]
["GABA receptor activation",0.000379538072280497,0.00103039513033597,0.00119858116064932]
["G alpha (i) signalling events",7.27507036342812E-014,7.02545285337465E-009,8.61200837360534E-009]
["G alpha (q) signalling events",7.80799108609667E-006,0.0116480239873138,0.00368689740374364]
["G alpha (s) signalling events",0.0180168515032421,"NA","NA"]
["G alpha (z) signalling events","NA","NA",0.0365187737505685]
["Gamma-carboxylation, transport, and amino-terminal cleavage of proteins",0.0112534008164341,"NA",0.0225091087384054]
["Gastrin-CREB signalling pathway via PKC and MAPK",0.00329410697118304,"NA","NA"]
["Generation of second messenger molecules",0.00928514000330795,0.0083985375698628,"NA"]
["Gluconeogenesis","NA","NA",0.0134458481303821]
["Glucose metabolism","NA","NA",0.0110878576230446]
["Glutathione conjugation","NA","NA",0.0305848246273256]
["Glycerophospholipid biosynthesis","NA","NA",0.0046715447190667]
["Glycolysis","NA","NA",0.0176775934170479]
["Glycosaminoglycan metabolism",0.00265207005791526,0.0386857345778341,0.001603165504261]
["Glyoxylate metabolism and glycine degradation","NA",0.00789375215520848,"NA"]
["GPCR downstream signaling",3.55170434547746E-017,6.07204762155037E-008,3.37852993129309E-009]
["GPCR ligand binding",4.61138903256033E-010,0.000571522408022288,6.51822788752106E-005]
["G protein gated Potassium channels",0.0237337247510071,"NA","NA"]
["GPVI-mediated activation cascade",0.0293698967826697,"NA","NA"]
["Hemostasis",1.28404207320829E-007,"NA",8.00081695680507E-005]
["Heparan sulfate/heparin (HS-GAG) metabolism",0.000624362306692041,"NA",0.00657167425269043]
["Highly calcium permeable postsynaptic nicotinic acetylcholine receptors",0.00157307888068498,0.00752691692574542,0.00360962118926008]
["Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism",0.00163121434523618,0.000651943316554141,0.0152344974414206]
["Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell",0.0128810326484618,"NA",0.0103955575420001]
["Incretin synthesis, secretion, and inactivation",0.0104305429559553,"NA","NA"]
["Inhibition  of voltage gated Ca2+ channels via Gbeta/gamma subunits",0.0237337247510071,"NA","NA"]
["Initial triggering of complement","NA",0.0408486861436164,0.033926759159923]
["Integration of energy metabolism","NA","NA",0.008170175164247]
["Integrin cell surface interactions",9.11245213482341E-006,0.0287575144057942,0.000582521682902056]
["Interactions of neurexins and neuroligins at synapses","NA","NA",0.0106476487494499]
["Inwardly rectifying K+ channels",0.00693305381634713,0.0394815183019785,"NA"]
["Ion channel transport",4.11809934731005E-007,0.000651943316554141,0.000167954291975631]
["Ligand-gated ion channel transport",0.00967069904152016,0.00863402517476007,"NA"]
["Lipoprotein metabolism",0.000388457473502222,0.000225979860689301,3.76589802574086E-006]
["Metabolism of Angiotensinogen to Angiotensins",0.00157307888068498,"NA","NA"]
["Metabolism of fat-soluble vitamins",2.67291647693656E-005,0.00139482343611606,0.000599344335739031]
["Metabolism of lipids","NA",4.38845585893614E-005,6.04282191770205E-006]
["Metabolism of vitamins and cofactors","NA",0.0112744834319286,0.0263951124453019]
["Mitochondrial Fatty Acid Beta-Oxidation","NA",0.00250926775296712,0.000437388587593949]
["mitochondrial fatty acid beta-oxidation of saturated fatty acids","NA",4.58516382134719E-005,1.61086103843895E-005]
["Mitotic Prometaphase","NA","NA",0.0293765392049019]
["Muscle contraction",3.18105833235443E-005,0.000263984643890154,0.00102854322941896]
["Neuronal System",3.55170434547746E-017,3.71769273828718E-013,1.86520627448363E-013]
["Neurotransmitter receptors and postsynaptic signal transmission",0.000423829965027203,0.00132729509088466,0.00153913783131811]
["O-linked glycosylation",0.044014797216188,"NA",0.0204015892591021]
["O-linked glycosylation of mucins",0.044014797216188,"NA","NA"]
["Peptide hormone metabolism",0.0198910306436065,"NA","NA"]
["Peptide ligand-binding receptors",1.81540009578361E-011,1.95684568090035E-005,1.72208361783759E-006]
["Peroxisomal lipid metabolism","NA",0.00716966134245587,0.00569150939233308]
["Phase 2 - plateau phase","NA",0.0199818114666516,"NA"]
["Phase I - Functionalization of compounds","NA","NA",0.0264651773288683]
["Phosphorylation of CD3 and TCR zeta chains",0.044014797216188,0.0427735120104097,"NA"]
["PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling",0.0434861131620853,"NA","NA"]
["Plasma lipoprotein assembly",0.00041991511343011,0.00103039513033597,0.00153913783131811]
["Plasma lipoprotein remodeling",7.05744421984346E-005,3.95698101563513E-005,2.82653688626528E-007]
["Platelet activation, signaling and aggregation",0.00908513382020538,"NA","NA"]
["Postsynaptic nicotinic acetylcholine receptors",0.00784799208938743,0.0246645427085786,0.0112331251194557]
["Post-translational modification: synthesis of GPI-anchored proteins",0.00200047027569677,"NA",0.0493153718272488]
["Post-translational protein phosphorylation",7.80799108609667E-006,"NA",0.00258797782890472]
["Potassium Channels",3.33213549571984E-011,7.02545285337465E-009,2.5693872472122E-008]
["Presynaptic nicotinic acetylcholine receptors",0.00279760197413372,0.0155656297978214,0.00504052708332719]
["Protein-protein interactions at synapses",0.0149380398383417,0.00407738690869041,0.000534605267375499]
["Pyruvate metabolism and Citric Acid (TCA) cycle","NA",0.0252877179186568,0.0489389080554233]
["RA biosynthesis pathway",0.0456841876525709,0.00499822856804866,0.0187451393267102]
["Receptor protein tyrosine phosphatases interactions","NA",0.0412068264806309,"NA"]
["Regulation of Complement cascade",0.000611127473392566,0.00328519475838425,0.00602733209649521]
["Regulation of IGF Activity by IGFBP",5.7129053145125E-009,0.00984798584237415,9.21105233255034E-005]
["Regulation of insulin secretion",0.0262382360667942,"NA","NA"]
["Regulation of TLR by endogenous ligand",0.00196700683887216,0.0012653166188404,0.0106476487494499]
["Removal of aminoterminal propeptides from gamma-carboxylated proteins",0.00967069904152016,"NA",0.0204015892591021]
["Resolution of Sister Chromatid Cohesion","NA","NA",0.0176775934170479]
["Retinoid metabolism and transport",2.67291647693656E-005,0.00139482343611606,0.000599344335739031]
["ROS, RNS production in phagocytes","NA","NA",0.0162543559233762]
["Scavenging by Class A Receptors",0.044014797216188,"NA","NA"]
["Scavenging by Class B Receptors","NA","NA",0.0278238212630859]
["Signaling by Retinoic Acid","NA",0.00103039513033597,0.00269577307679283]
["SLC-mediated transmembrane transport",4.46249146751645E-011,0.000225979860689301,3.41484038594565E-008]
["Stimuli-sensing channels",0.000140668465332274,0.0217352550928925,0.00341639230265273]
["Synthesis of very long-chain fatty acyl-CoAs","NA","NA",0.0351620513355522]
["Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)",0.00786777938781181,"NA",0.0428170456631224]
["The canonical retinoid cycle in rods (twilight vision)",0.0293698967826697,"NA",0.042849863220052]
["TNFs bind their physiological receptors",0.00294691597486323,0.0300902070193863,0.013998109398674]
["Trafficking and processing of endosomal TLR",0.0139277391178625,"NA",8.92667351153114E-005]
["Transmission across Chemical Synapses",5.75223663556448E-006,0.00051913566018703,0.000263282814708549]
["Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds",7.26603044671617E-007,0.00536437479179484,1.93585110878033E-005]
["Transport of inorganic cations/anions and amino acids/oligopeptides",1.66519930821002E-006,0.00218070313830701,4.49515443089026E-005]
["Triglyceride metabolism","NA","NA",0.00868984888973862]
["Tryptophan catabolism",0.0316202722180778,"NA","NA"]
["Visual phototransduction",0.000210644574736502,0.00957961258259584,0.00227080259634815]
["Voltage gated Potassium channels",5.7129053145125E-009,1.29152394565953E-007,3.05725999124113E-007]
["WNT ligand biogenesis and trafficking",0.0317994425963548,0.0260002261028059,0.0202585839756315]