{"text_format":"2","workbook":"xlsx","n_sheets":2,"sheets":["TECHNICAL_VALIDATION","BIOLOGICAL_VALIDATION"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"TECHNICAL_VALIDATION","index":0,"n_rows":100,"n_cols":8,"rows_kept":100,"cut":false,"hidden":false,"merged":[]}
["sample","meth","patient","agegroup","gene","cpg","beta","age"]
[10,9.84,"patient1","p0","HOXB7","cg07547765",0.0984,0]
[15,43.83,"patient1","p5","HOXB7","cg07547765",0.4383,5]
[110,38.72,"patient1","p10","HOXB7","cg07547765",0.3872,10]
[20,7.71,"patient2","p0","HOXB7","cg07547765",0.0771,0]
[25,26.72,"patient2","p5","HOXB7","cg07547765",0.2672,5]
[210,36.99,"patient2","p10","HOXB7","cg07547765",0.3699,10]
[30,9.89,"patient3","p0","HOXB7","cg07547765",0.0989,0]
[35,34.59,"patient3","p5","HOXB7","cg07547765",0.3459,5]
[310,37.07,"patient3","p10","HOXB7","cg07547765",0.3707,10]
[40,7.8,"patient4","p0","HOXB7","cg07547765",0.078,0]
[45,24.76,"patient4","p5","HOXB7","cg07547765",0.2476,5]
[410,28.86,"patient4","p10","HOXB7","cg07547765",0.2886,10]
[50,10.02,"patient5","p0","HOXB7","cg07547765",0.1002,0]
[55,31.75,"patient5","p5","HOXB7","cg07547765",0.3175,5]
[510,40.83,"patient5","p10","HOXB7","cg07547765",0.4083,10]
[60,12.77,"patient6","p0","HOXB7","cg07547765",0.1277,0]
[65,37.87,"patient6","p5","HOXB7","cg07547765",0.3787,5]
[610,52.21,"patient6","p10","HOXB7","cg07547765",0.5221,10]
[70,7.97,"patient7","p0","HOXB7","cg07547765",0.0797,0]
[75,27.45,"patient7","p5","HOXB7","cg07547765",0.2745,5]
[710,29.9,"patient7","p10","HOXB7","cg07547765",0.299,10]
[80,12.81,"patient8","p0","HOXB7","cg07547765",0.1281,0]
[85,26.52,"patient8","p5","HOXB7","cg07547765",0.2652,5]
[810,45.75,"patient8","p10","HOXB7","cg07547765",0.4575,10]
[90,12.57,"patient9","p0","HOXB7","cg07547765",0.1257,0]
[95,31.13,"patient9","p5","HOXB7","cg07547765",0.3113,5]
[910,37.6,"patient9","p10","HOXB7","cg07547765",0.376,10]
[100,10.76,"patient10","p0","HOXB7","cg07547765",0.1076,0]
[105,21.97,"patient10","p5","HOXB7","cg07547765",0.2197,5]
[1010,26.27,"patient10","p10","HOXB7","cg07547765",0.2627,10]
[110,9.47,"patient11","p0","HOXB7","cg07547765",0.0947,0]
[115,26.62,"patient11","p5","HOXB7","cg07547765",0.2662,5]
[1110,37.26,"patient11","p10","HOXB7","cg07547765",0.3726,10]
[10,26.24,"patient1","p0","SOCS3","cg11047325",0.2624,0]
[15,58.26,"patient1","p5","SOCS3","cg11047325",0.5826,5]
[110,54.93,"patient1","p10","SOCS3","cg11047325",0.5493,10]
[20,22.95,"patient2","p0","SOCS3","cg11047325",0.2295,0]
[25,37.96,"patient2","p5","SOCS3","cg11047325",0.3796,5]
[210,58.66,"patient2","p10","SOCS3","cg11047325",0.5866,10]
[30,28.73,"patient3","p0","SOCS3","cg11047325",0.2873,0]
[35,42.61,"patient3","p5","SOCS3","cg11047325",0.4261,5]
[310,57.93,"patient3","p10","SOCS3","cg11047325",0.5793,10]
[40,29.57,"patient4","p0","SOCS3","cg11047325",0.2957,0]
[45,49.28,"patient4","p5","SOCS3","cg11047325",0.4928,5]
[410,60.52,"patient4","p10","SOCS3","cg11047325",0.6052,10]
[50,32.45,"patient5","p0","SOCS3","cg11047325",0.3245,0]
[55,49.33,"patient5","p5","SOCS3","cg11047325",0.4933,5]
[510,61.59,"patient5","p10","SOCS3","cg11047325",0.6159,10]
[60,28.95,"patient6","p0","SOCS3","cg11047325",0.2895,0]
[65,73.39,"patient6","p5","SOCS3","cg11047325",0.7339,5]
[610,74.96,"patient6","p10","SOCS3","cg11047325",0.7496,10]
[70,31.93,"patient7","p0","SOCS3","cg11047325",0.3193,0]
[75,51.58,"patient7","p5","SOCS3","cg11047325",0.5158,5]
[710,63.05,"patient7","p10","SOCS3","cg11047325",0.6305,10]
[80,31.4,"patient8","p0","SOCS3","cg11047325",0.314,0]
[85,60.81,"patient8","p5","SOCS3","cg11047325",0.6081,5]
[810,68,"patient8","p10","SOCS3","cg11047325",0.68,10]
[90,34.88,"patient9","p0","SOCS3","cg11047325",0.3488,0]
[95,57.58,"patient9","p5","SOCS3","cg11047325",0.5758,5]
[910,62.97,"patient9","p10","SOCS3","cg11047325",0.6297,10]
[100,34.23,"patient10","p0","SOCS3","cg11047325",0.3423,0]
[105,47.89,"patient10","p5","SOCS3","cg11047325",0.4789,5]
[1010,60.19,"patient10","p10","SOCS3","cg11047325",0.6019,10]
[110,27.22,"patient11","p0","SOCS3","cg11047325",0.2722,0]
[115,64.88,"patient11","p5","SOCS3","cg11047325",0.6488,5]
[1110,73.15,"patient11","p10","SOCS3","cg11047325",0.7315,10]
[10,87.48,"patient1","p0","ZFPM2","cg03830443",0.8748,0]
[15,59.6,"patient1","p5","ZFPM2","cg03830443",0.596,5]
[110,52.54,"patient1","p10","ZFPM2","cg03830443",0.5254,10]
[20,86.25,"patient2","p0","ZFPM2","cg03830443",0.8625,0]
[25,50.09,"patient2","p5","ZFPM2","cg03830443",0.5009,5]
[210,50.25,"patient2","p10","ZFPM2","cg03830443",0.5025,10]
[30,85.49,"patient3","p0","ZFPM2","cg03830443",0.8549,0]
[35,51.75,"patient3","p5","ZFPM2","cg03830443",0.5175,5]
[310,36.01,"patient3","p10","ZFPM2","cg03830443",0.3601,10]
[40,90.76,"patient4","p0","ZFPM2","cg03830443",0.9076,0]
[45,68.96,"patient4","p5","ZFPM2","cg03830443",0.6896,5]
[410,54.97,"patient4","p10","ZFPM2","cg03830443",0.5497,10]
[50,89.9,"patient5","p0","ZFPM2","cg03830443",0.899,0]
[55,66.01,"patient5","p5","ZFPM2","cg03830443",0.6601,5]
[510,47.37,"patient5","p10","ZFPM2","cg03830443",0.4737,10]
[60,89.27,"patient6","p0","ZFPM2","cg03830443",0.8927,0]
[65,37.47,"patient6","p5","ZFPM2","cg03830443",0.3747,5]
[610,32.31,"patient6","p10","ZFPM2","cg03830443",0.3231,10]
[70,89.81,"patient7","p0","ZFPM2","cg03830443",0.8981,0]
[75,63.25,"patient7","p5","ZFPM2","cg03830443",0.6325,5]
[710,52.75,"patient7","p10","ZFPM2","cg03830443",0.5275,10]
[80,90.71,"patient8","p0","ZFPM2","cg03830443",0.9071,0]
[85,52.96,"patient8","p5","ZFPM2","cg03830443",0.5296,5]
[810,43.59,"patient8","p10","ZFPM2","cg03830443",0.4359,10]
[90,88.18,"patient9","p0","ZFPM2","cg03830443",0.8818,0]
[95,61.57,"patient9","p5","ZFPM2","cg03830443",0.6157,5]
[910,50.81,"patient9","p10","ZFPM2","cg03830443",0.5081,10]
[100,90.85,"patient10","p0","ZFPM2","cg03830443",0.9085,0]
[105,51.42,"patient10","p5","ZFPM2","cg03830443",0.5142,5]
[1010,49.02,"patient10","p10","ZFPM2","cg03830443",0.4902,10]
[110,85.95,"patient11","p0","ZFPM2","cg03830443",0.8595,0]
[115,44,"patient11","p5","ZFPM2","cg03830443",0.44,5]
[1110,33.36,"patient11","p10","ZFPM2","cg03830443",0.3336,10]

{"sheet":"BIOLOGICAL_VALIDATION","index":1,"n_rows":109,"n_cols":9,"rows_kept":109,"cut":false,"hidden":false,"merged":[]}
["sample","meth","patient","agegroup","gene","cpg","beta","age","group"]
[125,30.96,12,"p5","HOXB7","cg07547765",0.31,5,"fiveten"]
[1210,42.08,12,"p10","HOXB7","cg07547765",0.42,10,"fiveten"]
[135,21.92,13,"p5","HOXB7","cg07547765",0.22,5,"fiveten"]
[1310,27.32,13,"p10","HOXB7","cg07547765",0.27,10,"fiveten"]
[145,26.07,14,"p5","HOXB7","cg07547765",0.26,5,"fiveten"]
[1410,39.05,14,"p10","HOXB7","cg07547765",0.39,10,"fiveten"]
[155,48.55,15,"p5","HOXB7","cg07547765",0.49,5,"fiveten"]
[1510,57,15,"p10","HOXB7","cg07547765",0.57,10,"fiveten"]
[165,14.97,16,"p5","HOXB7","cg07547765",0.15,5,"fiveten"]
[1610,50.44,16,"p10","HOXB7","cg07547765",0.5,10,"fiveten"]
[175,24.76,17,"p5","HOXB7","cg07547765",0.25,5,"fiveten"]
[1710,25.23,17,"p10","HOXB7","cg07547765",0.25,10,"fiveten"]
[185,41.05,18,"p5","HOXB7","cg07547765",0.41,5,"fiveten"]
[1810,51.53,18,"p10","HOXB7","cg07547765",0.52,10,"fiveten"]
[195,39.05,19,"p5","HOXB7","cg07547765",0.39,5,"fiveten"]
[1910,44.2,19,"p10","HOXB7","cg07547765",0.44,10,"fiveten"]
[205,34.5,20,"p5","HOXB7","cg07547765",0.35,5,"fiveten"]
[2010,37.8,20,"p10","HOXB7","cg07547765",0.38,10,"fiveten"]
[400,11.53,40,"p0","HOXB7","cg07547765",0.12,0,"zerofive"]
[405,30.22,40,"p5","HOXB7","cg07547765",0.3,5,"zerofive"]
[410,11.3,41,"p0","HOXB7","cg07547765",0.11,0,"zerofive"]
[415,37.46,41,"p5","HOXB7","cg07547765",0.37,5,"zerofive"]
[420,10.21,42,"p0","HOXB7","cg07547765",0.1,0,"zerofive"]
[425,26.55,42,"p5","HOXB7","cg07547765",0.27,5,"zerofive"]
[430,11.13,43,"p0","HOXB7","cg07547765",0.11,0,"zerofive"]
[435,45.35,43,"p5","HOXB7","cg07547765",0.45,5,"zerofive"]
[440,23.57,44,"p0","HOXB7","cg07547765",0.24,0,"zerofive"]
[445,30.84,44,"p5","HOXB7","cg07547765",0.31,5,"zerofive"]
[450,10.84,45,"p0","HOXB7","cg07547765",0.11,0,"zerofive"]
[455,23.71,45,"p5","HOXB7","cg07547765",0.24,5,"zerofive"]
[460,11.6,46,"p0","HOXB7","cg07547765",0.12,0,"zerofive"]
[465,35.66,46,"p5","HOXB7","cg07547765",0.36,5,"zerofive"]
[470,12.11,47,"p0","HOXB7","cg07547765",0.12,0,"zerofive"]
[475,33.9,47,"p5","HOXB7","cg07547765",0.34,5,"zerofive"]
[480,23.19,48,"p0","HOXB7","cg07547765",0.23,0,"zerofive"]
[485,28.59,48,"p5","HOXB7","cg07547765",0.29,5,"zerofive"]
[125,56.23,12,"p5","SOCS3","cg11047325",0.56,5,"fiveten"]
[1210,66.41,12,"p10","SOCS3","cg11047325",0.66,10,"fiveten"]
[135,55.99,13,"p5","SOCS3","cg11047325",0.56,5,"fiveten"]
[1310,52.46,13,"p10","SOCS3","cg11047325",0.52,10,"fiveten"]
[145,55.51,14,"p5","SOCS3","cg11047325",0.56,5,"fiveten"]
[1410,66.48,14,"p10","SOCS3","cg11047325",0.66,10,"fiveten"]
[155,52.46,15,"p5","SOCS3","cg11047325",0.52,5,"fiveten"]
[1510,60.93,15,"p10","SOCS3","cg11047325",0.61,10,"fiveten"]
[165,59.32,16,"p5","SOCS3","cg11047325",0.59,5,"fiveten"]
[1610,63.31,16,"p10","SOCS3","cg11047325",0.63,10,"fiveten"]
[175,37.39,17,"p5","SOCS3","cg11047325",0.37,5,"fiveten"]
[1710,60.79,17,"p10","SOCS3","cg11047325",0.61,10,"fiveten"]
[185,62.6,18,"p5","SOCS3","cg11047325",0.63,5,"fiveten"]
[1810,69.29,18,"p10","SOCS3","cg11047325",0.69,10,"fiveten"]
[195,55.3,19,"p5","SOCS3","cg11047325",0.55,5,"fiveten"]
[1910,43.9,19,"p10","SOCS3","cg11047325",0.44,10,"fiveten"]
[205,53.15,20,"p5","SOCS3","cg11047325",0.53,5,"fiveten"]
[2010,57.52,20,"p10","SOCS3","cg11047325",0.58,10,"fiveten"]
[400,23.79,40,"p0","SOCS3","cg11047325",0.24,0,"zerofive"]
[405,52.52,40,"p5","SOCS3","cg11047325",0.53,5,"zerofive"]
[410,39.07,41,"p0","SOCS3","cg11047325",0.39,0,"zerofive"]
[415,48.76,41,"p5","SOCS3","cg11047325",0.49,5,"zerofive"]
[420,26.72,42,"p0","SOCS3","cg11047325",0.27,0,"zerofive"]
[425,44.54,42,"p5","SOCS3","cg11047325",0.45,5,"zerofive"]
[430,18.12,43,"p0","SOCS3","cg11047325",0.18,0,"zerofive"]
[435,38.07,43,"p5","SOCS3","cg11047325",0.38,5,"zerofive"]
[440,21.42,44,"p0","SOCS3","cg11047325",0.21,0,"zerofive"]
[445,45.02,44,"p5","SOCS3","cg11047325",0.45,5,"zerofive"]
[450,16.18,45,"p0","SOCS3","cg11047325",0.16,0,"zerofive"]
[455,22.59,45,"p5","SOCS3","cg11047325",0.23,5,"zerofive"]
[460,21.65,46,"p0","SOCS3","cg11047325",0.22,0,"zerofive"]
[465,31.63,46,"p5","SOCS3","cg11047325",0.32,5,"zerofive"]
[470,21.71,47,"p0","SOCS3","cg11047325",0.22,0,"zerofive"]
[475,27.11,47,"p5","SOCS3","cg11047325",0.27,5,"zerofive"]
[480,14.38,48,"p0","SOCS3","cg11047325",0.14,0,"zerofive"]
[485,26.59,48,"p5","SOCS3","cg11047325",0.27,5,"zerofive"]
[125,53.69,12,"p5","ZFPM2","cg03830443",0.54,5,"fiveten"]
[1210,34.53,12,"p10","ZFPM2","cg03830443",0.35,10,"fiveten"]
[135,57.08,13,"p5","ZFPM2","cg03830443",0.57,5,"fiveten"]
[1310,37.29,13,"p10","ZFPM2","cg03830443",0.37,10,"fiveten"]
[145,67.38,14,"p5","ZFPM2","cg03830443",0.67,5,"fiveten"]
[1410,51.71,14,"p10","ZFPM2","cg03830443",0.52,10,"fiveten"]
[155,51.85,15,"p5","ZFPM2","cg03830443",0.52,5,"fiveten"]
[1510,39.73,15,"p10","ZFPM2","cg03830443",0.4,10,"fiveten"]
[165,43.54,16,"p5","ZFPM2","cg03830443",0.44,5,"fiveten"]
[1610,37.6,16,"p10","ZFPM2","cg03830443",0.38,10,"fiveten"]
[175,66.62,17,"p5","ZFPM2","cg03830443",0.67,5,"fiveten"]
[1710,48.84,17,"p10","ZFPM2","cg03830443",0.49,10,"fiveten"]
[185,55.25,18,"p5","ZFPM2","cg03830443",0.55,5,"fiveten"]
[1810,44.62,18,"p10","ZFPM2","cg03830443",0.45,10,"fiveten"]
[195,68.66,19,"p5","ZFPM2","cg03830443",0.69,5,"fiveten"]
[1910,58.1,19,"p10","ZFPM2","cg03830443",0.58,10,"fiveten"]
[205,51.21,20,"p5","ZFPM2","cg03830443",0.51,5,"fiveten"]
[2010,47.84,20,"p10","ZFPM2","cg03830443",0.48,10,"fiveten"]
[400,84.98,40,"p0","ZFPM2","cg03830443",0.85,0,"zerofive"]
[405,63.25,40,"p5","ZFPM2","cg03830443",0.63,5,"zerofive"]
[410,87.88,41,"p0","ZFPM2","cg03830443",0.88,0,"zerofive"]
[415,66.89,41,"p5","ZFPM2","cg03830443",0.67,5,"zerofive"]
[420,89.39,42,"p0","ZFPM2","cg03830443",0.89,0,"zerofive"]
[425,49.34,42,"p5","ZFPM2","cg03830443",0.49,5,"zerofive"]
[430,90.11,43,"p0","ZFPM2","cg03830443",0.9,0,"zerofive"]
[435,54.85,43,"p5","ZFPM2","cg03830443",0.55,5,"zerofive"]
[440,87.9,44,"p0","ZFPM2","cg03830443",0.88,0,"zerofive"]
[445,31.99,44,"p5","ZFPM2","cg03830443",0.32,5,"zerofive"]
[450,90.19,45,"p0","ZFPM2","cg03830443",0.9,0,"zerofive"]
[455,49.43,45,"p5","ZFPM2","cg03830443",0.49,5,"zerofive"]
[460,88.87,46,"p0","ZFPM2","cg03830443",0.89,0,"zerofive"]
[465,46.58,46,"p5","ZFPM2","cg03830443",0.47,5,"zerofive"]
[470,89.72,47,"p0","ZFPM2","cg03830443",0.9,0,"zerofive"]
[475,56.73,47,"p5","ZFPM2","cg03830443",0.57,5,"zerofive"]
[480,78.63,48,"p0","ZFPM2","cg03830443",0.79,0,"zerofive"]
[485,64.16,48,"p5","ZFPM2","cg03830443",0.64,5,"zerofive"]