ONH Group 1 vs. PBMCs,,
Ingenuity Canonical Pathways, -log(p-value),Molecules
PI3K Signaling in B Lymphocytes,6.13,"CD81,BLNK,FYN,ATF3,Calm1 (includes others),CD79B,ITPR2,NFKBIE,ABL1,NFKB2,PLCL2,FCGR2B,NFKB1,NFATC1,BTK,FOS,JUN,NFAT5,CD180,PIK3CG,SYK,CREB1,PIK3CB,ELK1,MAP2K1,CR2"
B Cell Activating Factor Signaling,5.73,"MAP3K14,TRAF3,NFKBIE,NFKB2,NFKB1,NFATC1,FOS,TRAF2,NFAT5,JUN,IKBKAP,ELK1,TNFSF13B"
EIF2 Signaling,4.86,"RPS23,RPL39,EIF4A2,RPL7A,RPS11,RPL35,RPS20,RPS13,PIK3CG,SOS1,RPS5,RPS12,RPS17,RPL31,MAP2K1,RPS24,FGFR1,RPS8,EIF2B3,RPL23,RPL37A,RPS29,RPL9,RPL27,RPS26,RPL37,RPS25,RPS15A,PIK3CB,INSR,RPL41"
Role of NFAT in Regulation of the Immune Response,4.52,"BLNK,FYN,Calm1 (includes others),NFKBIE,GNA11,NFKB1,FCGR2B,NFATC1,NFAT5,JUN,GNAT1,GNA15,PIK3CG,HLA-DMB,SOS1,MAP2K1,PRKCQ,CD79B,FCGR2A,ITPR2,FGFR1,MEF2A,NFKB2,BTK,FOS,SYK,MEF2C,PIK3CB,IKBKAP"
Molecular Mechanisms of Cancer,4.44,"FYN,TGFBR1,PSENEN,NFKBIE,SUV39H1,RHOT2,GNA11,CTNNA1,ABL1,NFKB1,FAS,MYC,LAMTOR3,JUN,GNA15,GNAT1,RHOT1,PIK3CG,SOS1,TGFB2,BID,WNT4,ARHGEF3,MAP2K1,CHEK2,E2F2,FASLG,CDC25A,PRKDC,PAK4,ARHGEF4,PRKCQ,FGFR1,RALB,PTCH1,NFKB2,APC,SIN3A,FOS,NF1,RHOA,APH1B,PIK3CB,ARHGEF18,ELK1,CASP7,CDK2,CTNND1"
April Mediated Signaling,4.40,"MAP3K14,FOS,TRAF2,TRAF3,NFAT5,JUN,NFKBIE,NFKB2,NFKB1,ELK1,NFATC1"
IL-10 Signaling,4.23,"MAP3K14,BLVRA,FCGR2A,NFKBIE,NFKB2,FCGR2B,NFKB1,IL18RAP,FOS,HMOX1,JUN,IL1RL2,IL1RN,ELK1,IL1RAP"
T Cell Receptor Signaling,4.20,"FYN,Calm1 (includes others),PRKCQ,FGFR1,NFKB2,NFKB1,NFATC1,BTK,FOS,TXK,NFAT5,JUN,GRAP2,CARD11,PIK3CG,PAG1,SOS1,PIK3CB,ELK1,MAP2K1"
B Cell Receptor Signaling,3.64,"BLNK,Calm1 (includes others),NFKBIE,ABL1,NFKB1,FCGR2B,NFATC1,NFAT5,JUN,PIK3CG,SOS1,CREB1,MAP2K1,MAP3K14,PRKCQ,CD79B,FCGR2A,FGFR1,EGR1,NFKB2,BTK,MAP3K12,SYK,PAG1,MEF2C,PIK3CB,ELK1"
PPAR Signaling,3.64,"PPARG,MAP3K14,NFKBIE,NFKB2,NFKB1,IL18RAP,AIP,FOS,TRAF2,JUN,IL1RL2,IL1RN,SOS1,INSR,IL1RAP,MAP2K1,CITED2"
CD40 Signaling,3.53,"MAP3K14,TRAF3,NFKBIE,FGFR1,PTGS1,NFKB2,NFKB1,FOS,TRAF2,JUN,PIK3CG,PIK3CB,IKBKAP,MAP2K1,FCER2"
Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes,3.46,"FYN,Calm1 (includes others),TGFBR1,NFKBIE,NFKB2,NFKB1,NFATC1,FOS,NFAT5,JUN,CARD11,SOS1,TGFB2,ELK1,MAP2K1"
TWEAK Signaling,3.38,"MAP3K14,TRAF2,TRAF3,NFKBIE,BID,NFKB2,NFKB1,CASP7,TNFRSF12A"
Phospholipase C Signaling,3.23,"BLNK,FYN,Calm1 (includes others),RHOT2,FCGR2B,NFKB1,NFATC1,HMOX1,NFAT5,AHNAK,RHOT1,CREB1,HDAC7,SOS1,ARHGEF3,MAP2K1,ARHGEF4,PRKCQ,CD79B,FCGR2A,ITPR2,RALB,MEF2A,NFKB2,BTK,PLA2G4A,GRAP2,SYK,RHOA,ARHGEF18,MEF2C"
CD28 Signaling in T Helper Cells,3.19,"FYN,Calm1 (includes others),PRKCQ,ITPR2,NFKBIE,FGFR1,NFKB2,NFKB1,NFATC1,FOS,JUN,ARPC1A,NFAT5,GRAP2,CARD11,SYK,PIK3CG,HLA-DMB,PIK3CB,MAP2K1"
Small Cell Lung Cancer Signaling,3.17,"TRAF3,SUV39H1,FGFR1,NFKBIE,ABL1,NFKB2,NFKB1,SIN3A,MYC,TRAF2,PIK3CG,TRAF4,BID,PIK3CB,CDK2"
PEDF Signaling,3.17,"PPARG,ARHGAP22,FGFR1,NFKBIE,SERPINF1,NFKB2,NFKB1,FAS,ROCK2,RHOA,PIK3CG,PIK3CB,ELK1,CASP7,FASLG"
CD27 Signaling in Lymphocytes,3.09,"MAP3K12,MAP3K14,FOS,TRAF2,JUN,NFKBIE,BID,IKBKAP,NFKB2,NFKB1,MAP2K1"
4-1BB Signaling in T Lymphocytes,2.98,"MAP3K14,TRAF2,JUN,NFKBIE,IKBKAP,NFKB2,NFKB1,MAP2K1"
,,
ONH Group 2 vs. PBMCs,,
Ingenuity Canonical Pathways, -log(p-value),Molecules
tRNA Splicing,4.26,"PDE6G,PDE7A,TSEN34,TSEN54,PDE4B,PDE6B,PDE6D"
DNA Double-Strand Break Repair by Homologous Recombination,3.36,"LIG1,GEN1,RAD52,RPA1"
Relaxin Signaling,2.56,"VEGFA,PDE6G,PDE7A,GNA15,PIK3CG,GNA11,PDE4B,NFKB1,ELK1,PDE6B,PDE6D"
Pancreatic Adenocarcinoma Signaling,1.81,"VEGFA,CYP2E1,PIK3CG,PTGS2,NFKB1,ELK1,RALGDS,E2F2"
G-Protein Coupled Receptor Signaling,1.78,"PDE6G,PDE7A,GNA11,PDE4B,RAPGEF4,NFKB1,FPR1,GNA15,PIK3CG,ADORA2B,PTGER2,PDE6B,PDE6D,CAMK2B"
Tec Kinase Signaling,1.74,"STAT4,PAK4,TXK,GNA15,PIK3CG,GNA11,ITGA5,TNFSF10,NFKB1,ACTG1"
Tryptophan Degradation III (Eukaryotic),1.73,"HAAO,GCDH,KYNU"
Tryptophan Degradation to 2-amino-3-carboxymuconate Semialdehyde,1.73,"HAAO,KYNU"
Thrombin Signaling,1.62,"ARHGEF4,F2R,GNA15,PIK3CG,GNA11,TBP,PLCL2,ARHGEF3,NFKB1,ELK1,CAMK2B"
Thiamin Salvage III,1.56,TPK1
T Cell Receptor Signaling,1.53,"TXK,GRAP2,CARD11,PAG1,PIK3CG,NFKB1,ELK1"
NF-_B Activation by Viruses,1.52,"TRAF2,PIK3CG,TBP,ITGA5,NFKB1,ITGB3"
Altered T Cell and B Cell Signaling in Rheumatoid Arthritis,1.48,"SLAMF1,CD79B,CSF1,IL10,IL1RN,NFKB1"
IL-9 Signaling,1.47,"PIK3CG,CISH,BCL3,NFKB1"
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses,1.47,"LIF,IL10,PIK3CG,Oas1d (includes others),MAVS,NOD1,NFKB1,RIPK2"
Signaling by Rho Family GTPases,1.41,"PAK4,ARHGEF4,ARFIP2,GNA15,PIK3CG,GNA11,ITGA5,ARHGEF3,CDC42EP2,NFKB1,ELK1,ACTG1"
Death Receptor Signaling,1.40,"PARP6,TRAF2,CASP2,TNFSF10,NFKB1,ACTG1"
Agrin Interactions at Neuromuscular Junction,1.40,"CHRNA1,PAK4,ITGA5,ACTG1,ITGB3"
cAMP-mediated signaling,1.39,"AKAP12,PDE6G,PDE7A,ADORA2B,PTGER2,PDE4B,RAPGEF4,PDE6B,CAMK2B,PDE6D,FPR1"
,,
PANTHER Pathways,n,% Pathway
Inflammation mediated by chemokine and cytokine signaling pathway (P00031),30,0.019
Gonadotropin-releasing hormone receptor pathway (P06664),29,0.018
PDGF signaling pathway (P00047),26,0.016
CCKR signaling map (P06959),22,0.014
Apoptosis signaling pathway (P00006),21,0.013
Integrin signalling pathway (P00034),21,0.013
B cell activation (P00010),17,0.011
Angiogenesis (P00005),16,0.010
Wnt signaling pathway (P00057),15,0.009
T cell activation (P00053),14,0.009
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway (P00027),14,0.009
Interleukin signaling pathway (P00036),13,0.008
p53 pathway (P00059),12,0.008
Ras Pathway (P04393),12,0.008
EGF receptor signaling pathway (P00018),12,0.008
Oxidative stress response (P00046),11,0.007
Huntington disease (P00029),11,0.007
VEGF signaling pathway (P00056),10,0.006
Toll receptor signaling pathway (P00054),9,0.006
TGF-beta signaling pathway (P00052),9,0.006