>Human_HTR3B/1-441 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MLSSV MAPLWACILVAAGILATDTHHPQDSALY--------HLSKQLL-----QKYHKEVRP-VYNWTK-ATTVYLD LFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNS----SMFDEIRE-ISLP--LS---AIWAPDIIINE-- -FVDIERYPDLPY---VYVNSSGTIENYKPIQVVSACSLETYAFPFDVQNCSLTFKSILHTVEDVDLAF--- ---------------------LRSPEDIQHDKKAFLNDSEWELLSVSSTYSILQ---SSAGG--------FA Q----IQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPP-NC-RARIVFKTSVLVGYTVFRVNMSNQVP RSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRGGQE--------------QPFLC---LRG---- ------------------------------------------------------------------------ --------DTDADRPRVEPRA--------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------------------QRAVVTESSLYGEHL A-----------------------------------------------------QPGTLKEVWS-QLQSISN YLQTQDQTD-QQEAEWLVLLSRFDRLLFQSYLFMLGIYTITLCSLWALWGGV-------------------- ------------------------------------- >Human_HTR3A/1-484 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MLGKL AMLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLL-----TNYRKGVRP-VRDWRK-PTTVSID VIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNP----EDFDNITK-LSIP--TD---SIWVPDILINE-- -FVDVGKSPNIPY---VYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISL--- ---------------------WRLPEKVKSDRSVFMNQGEWELLGVLPYFREFS---MESSNY-------YA E----MKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPP-NS-GERVSFKITLLLGYSVFLIIVSDTLP ATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQ-QP-VPAWLRHLVLERIAWLLC---LRE---- ------------------------------------------------------------------------ -----------QSTSQRPPAT--------------------------------------------------- ----------------------SQATKTDDCSAMGNHCSHMGGPQDF------------------------- ---------------------------------------------------------EKSPRDRCSPPPPPR E-----------------------------------------------------ASLAVCGLLQ-ELSSIRQ FLEKRDEIR-EVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA-------------------- ------------------------------------- >Fruitfly_2L_1/1-441 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------MTTTPKIKAPVSGPGLPL LLQMLMGMLLMGLTSVPGATATADPKNANVK-ALD-RLHAGLF-----TNYDSDVQP-VFQGT--PTNVSLE MVVT-YIDIDELNGKLTTHCWLNLRWRDEERVWQP----SQYDNITQ-ITLK--SS---EVWTPQITLFN-- -----GDEGGLMAETQVTLSHDGHFRWMPPAVYTAYCELNMLNWPHDKQSCKLKIGSW---GLKVVLPE--- ---------------------NGTARGESLDHDDLVQSPEWEIVDSRAHFVSQD-Y--------------YG Y----MEYTLTAQRRSSMYTAVIYTPASCIVILALSAFWLPP-HMGGEKIMINGLLIIVIAAFLMYFAQLLP VLSNNTPLVVIFYSTSLLYLSVSTIVEVLVLYLATGKHK--RR-LPEALRKLLHGHLGTWLL---LSV---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------FSTTGESQAEKTKEM D-----------------------------------------------------EHPYEEADEQ-ESSPLGI NHTEVPGAK-ANQFDWALLATAVDRISFVSFSLAFLILAIRCSV---------------------------- ------------------------------------- >C.elegans_II_3/1-474 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MTLKIAFFTLILLVSIERVYSSD---------EEY-RLLKDLR-----EGYDPVERP-VADHRK-PVNVKLR LILQQLVDVDERNQVITLVVWNQYTWNDYKLRWSP----EEYGNITT-LQIP--HG---TLWKPDILLFN-- -SAN-EHF-DASFPVHMVVSSNGDVLFAPPGIVSFSCSLSMTWFPYDQQVCYLKFGSWTY-GKKLDLQI--- -------------------DDSDLPDGHKMDLQYYIPNGEFDLLATPAFRKSTTFL----DET-------YV E----LYFHMHLKRRTMYYGLNWIVPSILISLSNILGFTMPP-EC-GEKITLQITNFLSVMVFLAMVSEVAP PTSESIPIIAAFFSLSIVILGLSICASLIIVNIFFRHPKT-HR-MGDWTRYVFLEWLPWFLL---MSR--P- ------------------------------------------------------------------------ -------------EHTFCRPR-----------------------------------------REEEKNDEEA ------------------------GGDGTKLLENQQH----------------------------------- ---------------------------------------------------------QPRPRLLVNSQLVMD S-----------------------------------------------------TVPYLEEIIG-YLKVFKA KLDDDEEEE-EEILNWRFMAMVIDRLSLFLFTGLIFGTTALIFAFCPNLFTDSPIVDIE------------- ------------------------------------- >C.elegans_V_2/1-479 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---MLLPILLHFLLLITQLNGSP---------AEV-RLINDLM-----SGYVREERP-TLDSSK-PVVVSLG VFLQQIINLSEKEEQLEVNAWLKFQWRDENLRWEP----TAYENVTD-LRHP--PD---ALWTPDILLYN-- -SVD-SEF-DSSYKVNLVNYHTGNINWMPPGIFKVSCKLDIYWFPFDEQVCYFKFGSWTYTRDKIQLEK--- ---------------------------GDFDFSEFIPNGEWIIIDYRTNITVKQ-Y-ECCPEQ-------YE D----ITFTLHLRRRTLYYSFNLIAPVLLTMILVILGFTVSP-ET-CEKVGLQISVSLAICIFLTIMSELTP QTSEAVPLLGVFFHTCNFISVLATSFTVYVQSFHFRNQHV-HERMDFWMRFILLEWSPWLLR---MKM--P- ------------------------------------------------------------------------ -DRENNFQTLTESWKGRNRRE-----------------------------------------SMARTAFEYA -------------------DGPVTQIHSMGIMLKDNFEEL-------------------------------- ---------------------------------------------------------IYQVKQEKIADEKGI E-----------------------------------------------------RLRVLQKIYD-HVKMIRE HDDDNDEDS-RVALEWRFAAIVVDRLCLLAFSLLIVVVSIIIALRAPYLFA--------------------- ------------------------------------- >C.elegans_IV_1/1-544 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M EYCWLILKLCLLLALGRNGITQK---------SEG-DLYTELL-----EDYEPLERP-IENSSE-AVMVKMG LVLQQIVDVDEKNQVVDVNAWLKFSWVDYSLKWKP----EDYGGVTD-LRFR--KG---QLWTPDVLMYN-- -SAD-PQF-DSRYASNLLVYPNGLVNWMPPGLYRLSCKIQVVWFPFDVQECFLKFGSWTFDGTKLNLEI--- -------------------------DDNGFDISNYMQNGEWTLEGTTVKRNIQY-Y-QCCPEP-------YY D----LVFTFVIRRRALYYAFNLILPCILITMLTLVGFTFPP-DA-GEKMSLQITIMLSICIFQNYVAELSP PTSEAVPFLSAFFAVCLFTCACCVTATTLALNFHHRTGKS-HQ-MNNTFRLLMLEWIPWLLM---MRR--P- -------------------------------------------------------------------GYVAR CGKIVKQDDSEDEFEERQTRL---------------------------------DQQRIATIISQITVESNK PTPTFPRRVTIVDEVNSDGEAEEPLPPDEVIREEDDDVASMDDPPAWRSTTTTSQPPQSPAHLWW------- ---------------------------------------------------------NATNRMGNRVPVEQI A-----------------------------------------------------QLLVLQQVHG-HLSEINK HIREREKSK-KIEDDWKFSALVVDRICMVIFTSFLFGSTVALFASVPNITRSF------------------- ------------------------------------- >Opossum_4_2/1-451 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------LDT RWIVDLSTFSPFLLSGSQAAEGK---------LAQ-KLLHDLF-----TNYTSALRP-VKDTDQ-ALNVTLD VTLSQIIDMDERNQVLTLYLWIRQEWADAYLCWEP----EVYGGLDS-IRIP--SS---LVWRPDIVLYN-- -KAD-TQP-PASASTNVVLRHDGRVRWDAPAITRSSCRVDVAAFPFDSQSCRLTFGSWTHVGHQLDVWP--- -------------------------GAPGAGLADFVENVEWRVLGMPAQRSVVT-Y-GCCSEP-------YP D----VTYTLLLQRRAAAYVANLLLPCVLISLLAPLAFHLPA-DS-GEKVSLGVTVLLALTVFQLLLAENMP P-AESVPLIGKYYMTTMALVTASTALTILIMNLHYSGPGV-RP-VPAWAQTLLLGYLARGLC---VRE---- ------------------------------------------------------------------------ --------------------------------------------------------------RGEPCGGAQH -----------------------------PLVPRRPSVHPK------------------------------- ---------------------------------------------------------PRLGQGSASGPCSEP R-----------------------------------------------------CPCHQEALLR-HVGAIAV ACRSHRAAQ-RLRGDWKRLARVVDRFFLAVFFVMVLAMSLLVLGHAL------------------------- ------------------------------------- >Mouse_7_2/1-447 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MGTRS HHLGPGFLLLLFLPAECLGAEGR---------LAH-KLFRDLF-----ANYTSALRP-VADTDQ-TLNVTLE VTLSQIIDMDERNQVLTLYLWIRQEWTDAYLHWDP----KAYGDLDA-IRIP--SS---LVWRPDIVLYN-- -KAD-TQP-PASASTNVVVRHDGAVRWDAPAITRSSCRVDVSAFPFDAQRCGLTFGSWTHGGHQLDVRP--- -------------------------RGTSASLADFVENVEWRVLGMPARRRVLT-Y-GCCSEP-------YP D----VTFTLLLRRRAAAYVCNLLLPCVFISLLAPLAFHLPA-DS-GEKVSLGVTVLLALTVFQLILAESMP P-AESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPNA-HP-VPAWARVLLLGHLAKGLC---VRE---- ------------------------------------------------------------------------ -----RGEPCGQSKPLESAPS--------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------------------LQPPAGPPAGPCHEP R-----------------------------------------------------CLCHQEALLH-HVASIAG TFRSHRAAQ-RRHEDWKRLARVMDRFFLGIFFCMALVMSLLVLVQAL------------------------- ------------------------------------- >Human_11_CHRNA10/1-451 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MGLRS HHLSLGLLLLFLLPAECLGAEGR---------LAL-KLFRDLF-----ANYTSALRP-VADTDQ-TLNVTLE VTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDP----NAYGGLDA-IRIP--SS---LVWRPDIVLYN-- -KAD-AQP-PGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRP--- -------------------------RGAAASLADFVENVEWRVLGMPARRRVLT-Y-GCCSEP-------YP D----VTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPA-DS-GEKVSLGVTVLLALTVFQLLLAESMP P-AESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSV-RP-VPAWARALLLGHLARGLC---VRE---- ------------------------------------------------------------------------ ------------------------------------------------------------------RGEPCG ------------------------QSRPPELSPSPQS----------------------------------- ---------------------------------------------------------PEGGAGPPAGPCHEP R-----------------------------------------------------CLCRQEALLH-HVATIAN TFRSHRAAQ-RCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL------------------------- ------------------------------------- >Zebrafish_21_chrna10b/1-540 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------MLHLHSSEHRRDFIPHWRHKMNPRV ILASFYLIATVGFIPVCLCAQGR---------YAF-KLLKDLF-----VNYTSALRP-VEDTNN-IINVTLQ ITLSQIIDMDERNQILTTYLWIRQVWFDAYLTWNT----TDYDGLDT-IRIP--SS---YVWRPDVVLYN-- -NAD-DQF-SSSMETNVVIRHDGQIMWDQPAITKSSCKVDVSFFPFDVQHCRLTFGSWTHNGNQMDLHN--- -------------------------ALDSADLADFVENVEWEVQGMPAKKNVIL-Y-GCCSDP-------YP D----ITYTLHLKRRASFYIFNLLIPCMMISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLLVAESMP P-SENVPLIGKYYIATMTMITASTALTIFIMNIHHCGPEA-QP-VPSWARRFILNYLARFCF---VYD---- ----------------------------------------------------------------------MG QSCVSVHTDQPAKKGNNCTI------------------------------------------NGQARGEDFA --------LRLHEGCSQKVKDQFNEDASPTLSPQQRKEHQSGWRIGTFVEIEHGES---------------- ---------------------------------------------------------AGATGETGASRKESV K-------------KREILVESQ-------------------------------CLCHQQALLR-NVEYIAN FYQEQKATQ-RRNAEWRKVAKVMDRFFMWIFFIMVFLMSLLIIGKAV------------------------- ------------------------------------- >Medaka_14_2/1-543 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------MKIL CSRSMVLLLLPLFLSVCSAAQGR---------FAQ-KLLNDLF-----SNYTSALRP-VEDTDN-IINVTLQ ITLSQIIDMDERNQILTTYLWIRQVWMDAFLSWRK----EDYDGLDT-IRIP--SS---LVWRPDIVLYN-- -SAN-DEF-SSSMETNVVLRNDGQVMWDQPAITKSSCSVDVAFFPFDVQQCHLTFGSWTHNGNQMDLFN--- -------------------------ALDSADLSDFVPNVEWEVLGMPAKKNVIL-Y-GCCSDP-------YP D----ITFTLNLKRRASFYIFNLLIPCMMISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLLVAESMP P-SESVPLIGKYYIATMTMVTASTALTIFIMNIHHCGSEA-RP-VPQWAQRFVLNFLARICF---LRE---- ----------------------------------------------------------------------AG DSCLSRASSLKQPLSQQESDAPS-------------------------------AGAGTTGTNWDRNGQVWR GKVEEDNTGVSLSTEQDLTKQVIWKEDLFVTIDHSAERGAAGGHKEGEKSNSMSAGGVAAGEH--------- ---------------------------------------------------------AEEKSDVEGGAQQNR R-------------EILVRTQ---------------------------------CVCQHQRLRS-NVEFIAS SYQDQRVAQ-LRITEWRKVAKVMDRFFMWLFFILFFFMSVLILGKAI------------------------- ------------------------------------- >Fugu_scaffoldNW004072435/1-538 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M KPLHSGSLLLLLFLPVYFAAHGR---------FAQ-KLMTDLF-----SNYTNALRP-VEDTDH-IINVTLQ ITLSQIIDMDERNQILTTYLWVRQVWMDAYLTWKK----EDYDGLDT-IRIP--SS---YVWRPDIVLYN-- -SAD-DEF-SSSMETNVVLRHDGQVMWDQPAITKSSCSVDVAHFPFDLQECHLTFGSWTHNGNQMDLFN--- -------------------------ALDSADLADFVPNVEWEVLGMPAKKNVIL-Y-GCCSDP-------YP D----ITFTLHLKRRASFYIFNLLIPCMMISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLLVAESMP P-SESVPLIGKYYIATMTMVTASTALTIFIMNIHHCGSEA-HP-VPSWAERFILNYLARICF---VYE---- ----------------------------------------------------------------------VG ENCMDGTSSRQPSQMEAEVLS-------------------------------------ASGVNAKGANWDVN GQALGGRTDEDAASNTGQDVISDKDLKEDLFVTIDHSEEGAAKPCEVGKEEATSTFTGGEKEQAEEK----- ---------------------------------------------------------KGPGGQRGGRTRGSK R-------------EIFVKAQ---------------------------------CVCQHQGLCR-NIEYITS SYQDQRAAQ-LRIGEWRKVAKVMDRFFMWLFFIMVFIMSILILGKAI------------------------- ------------------------------------- >Stickleback_scaffold132/1-493 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------CLAAHGR---------YAQ-KLMSDLF-----TNYTSALRP-VEDTDH-IINVTLQ ITLSQIIDMDERNQILTTYLWIRQVWMDAYLTWKK----EDYDGLDT-IRIP--SS---YVWRPDIVLYN-- -SAD-DEF-SSSMETNVVLRNDGQVMWDQPAITKSSCSVDVAFFPFDLQQCHLTFGSWTHNGNQMDLFN--- -------------------------ALDSADLADFVPNVEWEVLGMPAKKNVIL-Y-GCCSDP-------YP D----ITFSLHLKRRASFYIFNLLIPCMMISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLLVAESMP P-SESVPLIGKYYIATMTMVTASTALTIFIMNIHHCGPEA-RP-VPSWAERFILNYLARVCF---VYE---- ----------------------------------------------------------------------AG ENCLGAAAKQRPPPPQPDAKR----------------------------------------RSWDVNGQVWA GRLVEEEGDGESAKLRRDLTTQTDWKEDMFVTVDDSEQEGAAGGGGE------------------------- ---------------------------------------------------------KKGLGGEVGGPGEEV PVR---------------------------------------------------TPCQHLGLCR-NVEYIAN SYQDQRAGQ-LRVGEWRKVAKVMDRFFMWLFFVMVFFMSILILGKAI------------------------- ------------------------------------- >Medaka_1_1/1-546 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MKRAALMVWISLLVQVSHCAQGH---------YAR-KLLKDLM-----EDYSSDLRP-VEDTDE-ALNVSLQ ITLSQIKDMDERNQVLTTYLWIRQVWHDAYLKWDK----EDYDDLEM-INIP--SD---RVWKPDIVLYN-- -KAD-EES-SGPSTTNVKLRYNGEIVWDSPAITKSSCVVDVSYFPFDWQSCNLTFGSWTYNGNQVDISL--- -------------------------GMDSGDLSDFVENVEWECHGMPAVRNVMM-Y-GCCSDP-------YT E----ITYTLLLKRRSSFYIFNLLLPCFLISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLLVAESMP P-AESMPYIGKYYIATMTMITASTSLTIFIMNIHFCGAEA-KP-VPHWAKVLIIDYMSKIFF---VYE--V- -----------------------------------------------------------------------G ENCTTPESKRTPLYPEEPMGVESVYYDDCC---------------------------HDSFLHHDSNPHKYS LQHHQHHKGQANGSINGCHHHRSNQNKNTARLGRGESNQDCTQHYHRIPRGEMDYQASPKPRNHLN------ ---------------------------------------------------------GGIKERILYPPEKHH D-------------QSCPCCC---------------------------------PCLQYKQLVK-NIQYIAN CFREQRATC-IKVAEWKKVAKVMDRFFMWIFFFMVFLMSILIIAKAS------------------------- ------------------------------------- >Fugu_17_1/1-538 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MRMATLMVWISLLVPVSHSAQGH---------YAR-KLLNDLM-----ENYSNALRP-VEDTDE-ALNVSLQ ITLSQIKDMDERNQVLTTYLWIRQVWHDAYLKWDK----EDYNDLEM-INIP--SD---LVWKPDIVLYN-- -KAD-EES-AGASNTNVKLRYNGEIVWDSPAITKSTCVVDVSYFPFDWQQCTLTFGSWTYNGNQVDISL--- -------------------------TMDSGDLSDFVENVEWECHGMPAVRKVRM-Y-GCCSDP-------YT E----VTFTLLLKRRSSFYIFNLLLPCFLISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLLVAESMP P-AESMPYIGKYYIATMTMITASTSLTIFIMNIHFCGAEA-KP-VPHWAKVLIIDYMSKIFF---VYE--V- -----------------------------------------------------------------------G ENCTTPESESIPLYPEETVSD-------------------------------NLDDSSHDLYLHQRETHKYS NGHGVHHHNNIQVNGNANHNNRTSRIDKIDQKQVNTQSYRHIRRDEINFQALSPPQNLQHLN---------- ---------------------------------------------------------GGLKEKLLYPAEKLT V-------------QACPGCC---------------------------------PCMQHKEVVK-NIQFIAN CFREQKATC-VKVAEWKKVAKVMDRFFMWIFFVMVFLMSILIIAKAS------------------------- ------------------------------------- >Stickleback_IX_1/1-506 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------SHGAQGH---------YAR-KLLADLM-----EDYSNALRP-VDDTDK-ALNVSLQ ITLSQIKDMDERNQVLTTYLWIRQVWHDAYLKWDK----EDYDDLEM-INIP--SD---LVWKPDIVLYN-- -KAD-EDS-AGESSTNVKLRYNGEIVWDSPAITKSSCVVDVSYFPFDWQQCKLTFGSWTYNGNQVDISL--- -------------------------GMDSGDLSDFVENVEWECHGMPAVRNVKM-Y-GCCSDP-------YT D----ITYTLLLKRRSSFYIFNLLLPCFLISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLLVAESMP P-AESMPYIGKYYIATMTMITASTSLTIFIMNIHFCGAEA-KP-VPHWAKVLIIDYMSKIFF---VYE---- ----------------------------------------------------------------------VG ENCTTPESEKEPPNNDHFLDY-------------------------------------------PDGGDPYE HSNGHAVPRRGRHHGSHANGNANNSRHQYSSRAAGPERGECERGHPAPPH---------------------- ---------------------------------------------------------PPNLRHLNGGPKERL LYPAAKLQLPACPCRC--------------------------------------PGLQHRQVVR-NIQYIAN CFREQKATC-VKAAEWKKVAKVMDRFFMWIFFVMVFLMSILIIAKAS------------------------- ------------------------------------- >Zebrafish_1_5_chrna9a/1-580 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MKTIFLVIHISLLLHAVFSAQGR---------FAQ-KLLNDLM-----EGYSNALRP-VEDTDK-ALNVTLQ ITLSQIKDMDERNQVLTTYLWVRQIWHDAYLSWDK----EEYDGLEV-IRIP--SN---LVWRPDIVLYN-- -NADEEDS-SGPPDTNVVLRYNGEITWDSPAITKSSCKVDVSYFPFDSQECNLTFGSWTYNGNQVDIAM--- -------------------------GMESGDLSDFVDNVEWECHGMPAVKNVIM-Y-GCCSDP-------YP D----ITYTVLLKRRSSFYIFNLLLPCFLISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLMVAESMP P-SESVPLIGKYYIATMTMITASTSLTIFIMNIHFCGAEA-KP-VPHWAKVLIIDYMSKIFF---VYE---- ----------------------------------------------------------------------VG ENCTTPESDRGPFFSEDPLAS----LERDGYFDKGFYEDCHLDERIRSQFNGYSHRDHRHGNGYHHKNSSYR QHRHEQQRRTRSSSNSPVRQSSHHPKYTHFIGRDGSEKLPLTSQEKLKDSEISIPEKINGYTY--------- ---------------------------------------------------------DQGNGYLNGVGYLHD NGYSKTFGADSYNKTTTGTGC---------------------------------VCGKHQKLVR-NIEYIAN CFREQRGHQ-AKGAEWKKVAKVMDRFFMWVFFIMVFLMSILVLAKAT------------------------- ------------------------------------- >Zebrafish_14_1_chrna9b/1-488 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MERTR RWMEVMLLSALLLAEASHCAQGR---------FAH-KLLNDLM-----EDYSSALRP-VDDTDK-SLNVTLQ VTLSQIKDMDERNQVLIAYLWIRQVWHDAHLKWSK----EDYDGLEV-IRIP--SS---LIWRPDLVLYN-- -KAD-DDF-SGPVDTNVVLRYTGEITWDAPAITKSSCVVDVSYFPFDSQQCNLTFGSWTYNGNQVDIAM--- -------------------------GSVSGDLSDFVENVEWECHGMPATKNVIM-Y-GCCSDP-------YP D----ITYTVLLQRRSSFYIINLLLPCFLISFLAPLSFYLPA-DS-GEKVSLGVTVLLALTVFQMMVAESMP P-SESVPLIAKYYIATMTMITASTALTIFIMNIHFCGAEA-KP-VPYWAKVLIIDYMSKIFF---VYE---- ----------------------------------------------------------------------VG ESCASPFGQAEESESFH------------------------------------------------------- ---------------------SQNHHRKHKLHHPKGKISGSPPPCCPE------------------------ ---------------------------------------------------------DHKSPFVLGCESCVY C-------------GFRSGN----------------------------------LACDTK-LLR-NVEYIAN CFREQKTTA-LKVAEWKKVAKVMDRFFMWIFFIMVFLMSILIIGKAPTTNNDI------------------- ------------------------------------- >Medaka_10_5/1-536 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------VHSAQGQ---------YAQ-KLLNDLM-----ENYSNALRP-VEDTDS-ALNVTLQ VTLSQIKDMDERNQVLIAYLWIRQTWHDAYLKWNK----DDYDGLDV-IHIP--SS---LVWRPDLVLYN-- -KAD-DDF-SGPMDTNVKLRYNGEITWDAPAITKSSCVVDVSYFPFDSQECNLTFGSWTYNGNQVDIYM--- -------------------------GMDSGDLSDFVENVEWECHGMPATKNVIM-Y-GCCSDP-------YP D----ITYTVLLQRRSSFYIFNLLLPCFLISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLMVAESMP P-SESVPLIGKYYIATMTMVTASTALTIFIMNIHFCGAEA-KP-VPHWAKVLIIDYMSKIFF---VYE--V- -----------------------------------------------------------------------G ENCASASLQSSHGLKDDASNQ------------------------------------HSHIHANGRPGSHHS QEDWQSHKYKPPRSQASLVQQQHRVEVQHHIMREENECFSSFSPGKYEGSNEKIPMTDFSSEDRQVPC---- ---------------------------------------------------------CPEDQKLPCCPEDKP PLLNCPTVTFRSCVFCSHRGG---------------------------------IPKMDNKLMQ-NVEFIAN CFREQRATC-VKGAEWKKIAKVMDRFFMWIFFIMVFLMSILIIGKAK------------------------- ------------------------------------- >Fugu_14_5/1-526 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MLPVICLVMLLPEVVHSAEGR---------YAQ-KLLNDLM-----ENYSSALRP-VGDTDS-ALNVTLQ ITLSQIKDMDERNQVLIAYLWIRQRWNDAYLKWNK----EDYDGLEV-IHIP--SN---LVWRPDLVLYN-- -KAD-DDF-SGPMDTNVKLRYNGEITWDAPAITKSSCVVDVSYFPFDSQECNLTFGSWTYNGNQVDIIM--- -------------------------GMDSGDLSDFVENVEWECRGMPATKNVIM-Y-GCCSDP-------YP D----ITYTVLLQRRSSFYIFNLLLPCFLISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLMVAESMP P-SESVPLIGKYYIATMTMVTASTSLTIFIMNIHFCGAEA-KP-VPHWAKVLIIDYMSKIFF---VYE--V- -----------------------------------------------------------------------G ENCASSSSSSSSHPPQEEAHH------------------------------------KHLSYHAHVNGKPGG DTCQMSRGPAQHHITREDMNHLSGYDGSNGKIPTGDFCKVDQKMLYYPEESKLSSSL--------------- ---------------------------------------------------------EDKKPRGPVVTFGPC V-------------FCSYGSG---------------------------------LAAMDNKLVR-NVEYIAN CFREQRATC-AKVAEWKKVAKVMDRFFMWIFFIMVFLMSILVIGKAQ------------------------- ------------------------------------- >Stickleback_IV_4/1-557 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MIPIMYLVLLLPEVTQSAQGQ---------YAH-KLLNDLM-----ENYSSALRP-VEDTDR-ALNVTLQ ITLSQIKDMDERNQVLIAYLWIRQTWHDAYLKWDK----EDYDGLEV-IHIP--SS---LVWRPDLVLYN-- -KAD-DDF-SGPMDTNVRLRYNGEITWDAPAITKSSCVVDVSYFPFDSQECNLTFGSWTYNGNQVDIIM--- -------------------------GMDSGDLSDFVENVEWECHGMPATKNVIM-Y-GCCSDP-------YP D----ITYTVLLQRRSSFYIFNLLLPCFLISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLMVAESMP P-SESVPLIGKYYIATMTMVTASTSLTIFIMNIHFCGAEA-KP-VPHWAKVLIIDYMSKIFF---VYE---- ----------------------------------------------------------------------VG ENCASASSSSSSSHLDDLCNQ-----------------------------HLNSHIHANGKPGSHASRQDWQ GHRHPRPQTPKLQHHPRVKAQHHITREERSHFSGAAPGKYEGSNGKTPAGDCCKEDQKVPGYREHQK----- ---------------------------------------------------------PPCCHEDKKPPCCHE DKKPPPPEGPTVTFGPCVFCSG--------------------------------FSGGDTKLVR-NVEYIAN CFREQRATC-AKGAEWKKIAKVMDRFFMWIFFIMVFLMSILIIGKAP------------------------- ------------------------------------- >SpottedGar_LG3_1/1-523 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MRVWT VRVTMRFLLCLNLLPACWGAQGK---------YAH-KLLNDLF-----ANYTSALRP-VEDTDK-AMNVTLQ ITLSQIIDMDERNQILTAYLWIRQVWIDAYLTWNK----DDYDGLDT-IRIP--SS---YVWRPDIVLYN-- -NAD-DQF-TGSMETNVVIRHDGQIMWDSPAITKSSCKVDVSFFPFDAQQCRLTFGSWTYNGNQIDILN--- -------------------------ALDTGDLTDFVENVEWEVLGMPAKKSVIL-Y-GCCSDP-------YP D----VTYTLNLKRRASFYVFNLLIPCVMISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLLVAESMP P-SENVPLIGKYYIATMTMITASTALTIFIMNIHHCGPEA-KP-VPRWAKKVILQYMARIFF---VYE---- ----------------------------------------------------------------------VG ENCTSPQPEKPEPSSQTSTGW---------------------------------------TMNGQARKDDFV LKVRRSQEGLAQKIQALKDEIEQGVSPDGTGGEHPTKTYGSWKEEGTFV----------------------- ---------------------------------------------------------SLDHGDLNGRGGSVK G------------KEAVCKAQ---------------------------------CLCHHQQLLR-NIEYIAN FYRDQRATQ-KRTGEWKKVAKVMDRFFMWIFFIMVFFMSLLIMGKAL------------------------- ------------------------------------- >Coelacanth_scaffoldJH128793/1-498 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------CLGAQGK---------YAY-KLLDDLF-----SNYSNALRP-VEDTDK-ALNVTLQ ITLSQIIDMDERNQILTAYLWIRQVWIDAYLRWNK----DDYDGLDA-IRIP--SS---YVWRPDIVLYN-- -NAD-DQF-TGSMETNVVLRHDGQIMWDSPAITKSSCKVDVSFFPFDGQQCRLTFGSWTHNGNQIDILN--- -------------------------RLDSGDLTDFVENVEWEVLGMPAKKNVIL-Y-GCCSEP-------YP D----MTYTLILKRRASFYIFNLLIPCVMISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLLVAENMP P-SENVPLIGKYYIATMTMITASTALTIFIMNIHHCGPEA-KP-VPKWAKTFILEYMARIFF---VYE---- ----------------------------------------------------------------------VG ESCRSAQTEKPDPPPLVSGTQ------------------------------------------IMNGQAKSE DPRQKLKKNEEPPALKLSHEEVENLEQGLSSYPSLGNMAASGYNSWKEESKYVAL----------------- ---------------------------------------------------------DHGVGKEVAQGSCCK A-----------------------------------------------------QCPCHHERLHRNIEFIAK CFRDQKAAQ-KRTSEWKKVAKVMDRFFMWIFFIMVFFMSLLILSKAI------------------------- ------------------------------------- >Chicken_1/1-452 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------MGSAPLT ACLLALSLAGTVLAPGCGAAQGR---------LAH-KLLHDLF-----ANYSSALRP-AEDTER-ALNVTLQ VTLSQIIDMDERNQVLTSYLWVRQAWLDAHLAWDK----DAYGGIDS-IRIP--SS---YVWRPDIVLYN-- -NAD-ERF-GGSMETNVVLRSDGHIMWDSPAITKSSCKVDVSYFPFDGQQCRLTFGSWTYNGNQIDLRN--- -------------------------LLDTGDLTDFVENVEWEVLGMPATRNVVT-Y-GCCSEP-------YP D----VTYMLLLRRRASFYIFNLLLPCVMISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLLVAESMP P-SESVPLIGKYYIATMTMITASTALTIFIMNIHHCGPGA-RP-VPPWARRLILHHLARALC---VCE---- ----------------------------------------------------------------------VG ESCGRPQREGTGGMGPR------------------------------------------------------- ------------------------------------------------------------------------ ---------------------------------------------------------DPPGEGVEPGLCPRS R-----------------------------------------------------CLCHHHAVLS-SVGYIAG VFRRHRTAQ-RRAAEWKKVAKVMDRFFMWVFFLMVFLMSVLVIGKAA------------------------- ------------------------------------- >AnoleLizard_scaffoldGL344444/1-447 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------VSGAQGR---------FAY-KLLSDLF-----ANYSNALRP-AEDTDR-ALNVTLQ VTLSQIIDMDERNQILTAYLWIRQVWVDAYLSWER----EAYDGIDS-IRIP--SS---YVWRPDIVLYN-- -NAD-DQF-TGSMETNVVIRHDGQITWDSPAITKSSCKVDVSYFPFDGQQCRLTYGSWTYNGNQIDLLN--- -------------------------KQETGDLTDFVANVEWEVLGMPARRNVIT-Y-GCCSEP-------YP D----VTYTLHLKRRASFYIFNLLLPCVMISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLLVAESMP P-SENVPLIGKYYIATMTMITASTALTIFIMNIHHCGPGA-KP-VPQWAKVLILHYMARIFF---VYE---- ----------------------------------------------------------------------VG ESCRSPRPEPDPSPKAPV------------------------------------------------GSGGAR ----------------------GPASPGEAFVDLE------------------------------------- ---------------------------------------------------------GVPGGSASCAKGGC- ------------------------------------------------------LCRQGSSILR-NVEYIAN CFRDQKAAS-KRTGEWKKVAKVMDRFFMWVFFAMVFIMSVLIMGQAV------------------------- ------------------------------------- >WesternClawedFrog_scaffoldNW016683661/1-501 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MRLPCLLACCLCLLPGVQGAQGR---------FAY-KLMNDLF-----ANYSNALRP-VEDMDK-AMNVTLQ VTLSQIIDMDERNQILMAYLWIRQVWFDAYLRWNK----EDYDGLDT-IRIP--SS---YVWRPDIVLYN-- -NAD-DQF-TGSMETNVVIRYDGQIMWDSPAITKSSCKVDVSFFPFDGQQCRLTFGSWTYNGNQIDILN--- -------------------------HLDTGDLTDFVENVEWEILGMPAKKSVIT-Y-GCCSEP-------YP D----VTYTLILKRRASFYIFNLLLPCVMISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLLVAESMP P-SENVPLIGKYYIATMTMITASTALTIFIMNIHHCGPEA-KP-VPQWAKKFILQYMSRIFF---VYE---- ----------------------------------------------------------------------VG ESCRRPRTEPEPNSERTSKVP---------------------------------------GIDGQAKREDIA ---------------------DVVKDCPEKLSPKDKEAKEELEHSKYAHSQESGKYYVSEQ----------- ---------------------------------------------------------GGVGKGFGYEECPKI H-----------------------------------------------------CLCHNERLLK-NIEYIAN CFRDQRATQ-KRTGEWKKVAKVMDRFFMWVFFIMVFLMSVLIMGKAI------------------------- ------------------------------------- >Zebrafish_15_chrna10a/1-527 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MILYYILKQFFLSLLVCWGANGI---------YAQ-KLLNDLF-----NNYTSALRP-VEDTED-ILNVTLQ ITLSQIIDMDERNQILTAYLWIRQVWIDKYLTWNK----ENYDGLDT-IRIP--GS---YVWRPDIVLYN-- -SAD-DHF-TSTMDTNVVIRHDGQIMWDAPAITKSSCKVDVSFFPFDAQQCRLTYGSWTYNGNQLDILN--- -------------------------AMESADLADLVDNVEWEVLGMPAKRNIIL-Y-GCCADP-------YP D----VTYTLKLKRRASFYVFNLLIPCVMISFLAPLGFYLPA-DS-GEKVSLGVTVMLALTVFQLLVAEIMP P-SENVPLIGKYYIATMTMITASTALTIFVMNIHHCGPDA-KP-VPDWAKKFILQYLARICF---VYE---- ----------------------------------------------------------------------VG ENCMTPQPEKPDPQPQKPQDC-------------------------------------NCNMNGQAGKDDFV FKFDRNQEATSPKLLEDREDMSQILSPACSLGKHPTCRYGVWKEGVFMSMDCGDGAA--------------- ---------------------------------------------------------ETGKPIGRGQEGCRD H-------------DSGFKSQ---------------------------------CKCDQQHLLR-NIEYVAN CYRDQRATA-RRTGEWKKVAKVLDRFFMWLFFIMVFFMSLLIMGKAI------------------------- ------------------------------------- >Medaka_13/1-532 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------MLCCIKMRR WTIVFCWFLCVIVMPTCWCARAK---------YAK-KLLTDLM-----SNYTKALIP-VEDTNI-ILNVTLQ VTLSQIIDMDERNQILTAYLWIRQVWFDAHLKWNK----EDFDGLDT-IRIP--GS---YVWRPDIVLYN-- -SAD-DRF-TGPMDTNVVIRHDGQMMWDSPYITKSSCKVDVSFFPFDAQQCRFTYGSWTYNGNQLDIQN--- -------------------------AMESADLADLVENVEWEVLGMPAKKNIVL-Y-GCCADP-------YP D----VTFTLKLKRRASFYVFNLLIPCVMISFLAPLGFYLPA-DS-GEKVSLGVTVMLALTVFQLLVAEIMP P-SENVPLIGKYYIATMTMITASTALTIFIMNIHHCGPDA-KP-VPKWAKKVILQYMARVCF---VYE---- ----------------------------------------------------------------------VG ENCMMSQPEKHEAPCAKNSPM-----------------------------------------NGQVGSGREE SVSKADGGQETAGSIITEGKEDLDQLTSLSSSVRKNQTNNCPWQSGVFMSLDCEDSG--------------- ---------------------------------------------------------AHTRRRKGGVSDEEK K-------------DGDVFCR---------------------------------RHSDEHLLLR-DIEYIAN YYRDQRATQ-KRTGEWKKVAKVLDRFFMWMFFILVFFMSLLIMGKAV------------------------- ------------------------------------- >Fugu_11/1-530 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MKRWT RETVFLLTLCLSVLPPCWTAHGK---------YAQ-KLLTDLF-----ASYTSALRP-VEDTNN-ILNVTLQ VTLSQIIDMDERNQILTAYLWIRQVWVDAYLKWNK----DEYDGLDT-IRIP--SS---YVWRPDIVLYN-- -NAD-DHF-TGPMDTNVVIRHDGQITWDSPAITKSSCRVDVSFFPFDAQQCRFTYGSWTYNGNQLDILN--- -------------------------ALESADLADLVENVEWEILGMPAKKNIIQ-Y-GCCADP-------YP D----VTYTLKLKRRASFYVFNLLIPCVMISFLAPLGFYLPA-DS-GEKVSLGVTVMLALTVFQLLVAEIMP P-SENVPLIGKYYIATMTMITASTALTIFIMNIHHCGPDA-KP-VPKWAKTVILQYMARMCF---VYE---- ----------------------------------------------------------------------VG DNCMSPQPEKPEPPYVKNSNC-------------------------------------TMNGRAGPCREDCV FRVEKGHDPAGPATAEEREEMDQMMSPIGSMGKNPTNRYGTWKNGVFLSTDGGDV----------------- ---------------------------------------------------------GDQRRCRKGGVSDGE R-------------TGQAPCS---------------------------------SQSSERQLLR-NIEYIAN CYRDQRATQ-KRTGEWKKVAKVLDRFFMWMFFIMVFFMSLLIMGKAI------------------------- ------------------------------------- >Stickleback_I/1-507 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------CWCAQGK---------YAQ-KLLNDLF-----TNYTSALRP-VEDTTT-ILNVTLQ VTLSQIIDMDERNQILTAYLWIRQVWFDAHLKWNK----DDYDGLDT-IRIP--SS---YVWRPDIVLYN-- -NAD-DHF-TGSMDTNVVIRHDGQMMWDSPAITKSSCKVDVSFFPFDAQQCRFTYGSWTYNGNQLDILN--- -------------------------AMESADLADLVENVEWVVLGMPANKNIVQ-Y-GCCADP-------YP D----VTFTLKLNRRASFYVYNLLIPCVMISFLAPLGFYLPA-DS-GEKVSLGVTVMLALTVFQLLVAEIMP P-SENVPLIGKYYIATMTMITTSTALTIFIMNIHHCGPDA-KP-VPKWAKKVILQYMARMCF---VFE---- ----------------------------------------------------------------------VG ENCLSPQPEKEEPPLVRNTNC-----------------------------------------GMNGQAGPGR EDCVFRMEAGHETVDAEEREDADQTMSPIGSIGKNPTSNYSTWKHGSYMSMDCGEAG--------------- ---------------------------------------------------------GQTRCRKGGVSDGER R-------------DGEVSCN---------------------------------SQSSERQLLR-NIEYIAN CYRDQRATQ-KRTGEWKKVAKVLDRFFMWIFFIMVFFLSLLIMGKAI------------------------- ------------------------------------- >AustralianGhostshark_scaffoldNW006890064/1-494 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------EAESADGR---------YAH-LLLKTLF-----EDYTNALRP-VEDTDR-ALNVTLK VTLSQIKDIDERNQILTAYLWIRQIWFDAFLTWDR----DKYDGLDS-IRIP--SS---YLWRPDIVLYN-- -KAD-DQS-GESMETNVVLRYDGRVTWDSPAITKSSCVVDVSYFPFDNQRCNLTFGSWTYNGNQVDIDD--- -------------------------ALDSGDLTDFVENVEWEVHGMPATKNVII-Y-GCCSDP-------YP D----ITYTLILKRRSSFYIFNLLLPCVMISSLAPLGFYLSA-DS-GEKVSLGVTVLLALTVFQLMVAESMP P-SDSVPLIGKYYIATMTMITASTALTIIIMNIHHCGPDA-KP-VPKWAKVIILQYMSKMFF---VYE---- ----------------------------------------------------------------------IG ENCTMSQKKEEKRDYKMQINN--------------------------------------------SKTNAKF RKEQEMRIKAQFSKEYHSNTMTLKEEESRSVIPLQRCPVCNQKESN-------------------------- ---------------------------------------------------------GQSNRGAADSYASEE D-------------VDLTPCI---------------------------------CSFHQGRVAK-NIEFIAN CFREQKATN-AKSAEWKKVAKVIDRFFMWIFFVMVFFMSFLIIGKAT------------------------- ------------------------------------- >Opossum_5/1-480 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MYWSHS CFALCWIVWAALRLRGKRTTEGK---------YAQ-KLFNDLF-----EDYSNALRP-VEDTDK-VLNVTLQ ITLSQIKDMDERNQILTAYLWIRQIWYDAYLKWDR----DQYDGLDS-IRIP--SD---LVWRPDIVLYN-- -KAD-DES-SEPVNTNVVLRYDGLITWDAPAITKSSCVVDVSYFPFDDQQCNLTFGSWTYNGNQVDIFN--- -------------------------ALDSGDLSDFIEDVEWEIHGMPAVKNVIT-Y-GCCSEP-------YP D----ITFTLILKRKSSFYIVNLLIPCVLISFLAPLSFYLPA-AS-GEKVSLGVTVLLAMTVFQLMVAEIMP P-SENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEA-KP-VPQWARIVILKYMSKILL---VYD---- ----------------------------------------------------------------------VG ESCTNPCHSKERGHQRKDYGK---------------------------------------------LPELYQ ----------------------KGPRNRNNGIAQKKETNKLL------------------------------ ---------------------------------------------------------NNDLGIQGENPKEAD N-----------------------------------------------------YCARYTALTR-NIEYIAK CLKDHRSNN-AKGIEWKKVAKVIDRFFMWIFFIMVFAMSILIMAKA-------------------------- ------------------------------------- >Mouse_5/1-480 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MNRPHP CISFCWMYFAASGIKAVETANGK---------YAQ-KLFSDLF-----EDYSNALRP-VEDTDA-VLNVTLQ VTLSQIKDMDERNQILTAYLWIRQTWHDAYLTWDR----DQYDGLDS-IRIP--SD---LVWRPDIVLYN-- -KAD-DES-SEPVNTNVVLRYDGLITWDSPAITKSSCVVDVTYFPFDSQQCNLTFGSWTYNGNQVDIFN--- -------------------------ALDSGDLSDFIEDVEWEVQGMPAVKNVIS-Y-GCCSEP-------YP D----VTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPA-AS-GEKVSLGVTILLAMTVFQLMVAEIMP A-SENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEA-RP-VPHWAKVVILKYMSRILF---VYD---- ----------------------------------------------------------------------VG ESCLSPRHSQEPEQITKVYGK--------------------------------------------LPGSNLK ------------------------ASRNKDLSRKKELRKLL------------------------------- ---------------------------------------------------------KNDLGYQGGIPQNTD S-----------------------------------------------------YCARYEALTK-NIEYIAK CLKDHKATN-SKGSEWKKVAKVIDRFFMWIFFAMVFVMTVLIIARAD------------------------- ------------------------------------- >Human_4_CHRNA9/1-479 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MNWSHS CISFCWIYFAASRLRAAETADGK---------YAQ-KLFNDLF-----EDYSNALRP-VEDTDK-VLNVTLQ ITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDR----DQYDGLDS-IRIP--SD---LVWRPDIVLYN-- -KAD-DES-SEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFN--- -------------------------ALDSGDLSDFIEDVEWEVHGMPAVKNVIS-Y-GCCSEP-------YP D----VTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPA-AS-GEKVSLGVTILLAMTVFQLMVAEIMP A-SENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEA-RP-VPHWARVVILKYMSRVLF---VYD---- ----------------------------------------------------------------------VG ESCLSPHHSRERDHLTKVYSK----------------------------------------------LPESN ----------------------LKAARNKDLSRKKDMNKRL------------------------------- ---------------------------------------------------------KNDLGCQGKNPQEAE S-----------------------------------------------------YCAQYKVLTR-NIEYIAK CLKDHKATN-SKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD------------------------- ------------------------------------- >WesternClawedFrog_1_1/1-494 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------MHTFLAR VGQLLFHVFVLLDLKGVESAKGK---------YAQ-MLFRDLF-----EDYSNALRP-VEDTDK-ALNVSLQ ITLSQIKDVDERNQILTAYLWIRLSWYDAYLKWDR----DEYDGLDS-IRIP--SN---MVWRPDIVLYN-- -KAD-DEF-SEPVNTNVVLRYDGKITWDSPAITKSSCVVDVSYFPFDNQQCNLTFGSWTYNGNQVDIIN--- -------------------------TMDSGDLSDFVENVEWEMQGMPAVKNVIT-Y-GCCSEP-------YP D----ITFTLILKRRSSFYIFNLLIPCVMISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLMVAESMP P-SESVPLIGKYYIATMTMITASTALTIIIMNIHLCGPEA-KP-IPRWARIVILDYMSKIFF---VYD---- ----------------------------------------------------------------------VG ENCTSPQSDSDTKSNGSVPSY----------------------------------------EDYEKEQEPYS ----------------SLGCPLSGSGNFSCDIDTNKKLNGHLG----------------------------- ---------------------------------------------------------GHYALQKEISETHCC A-----------------------------------------------------HCNRYRVLTN-NIEYITN WYREQKAIS-AKGIEWKKVAKVMDRFFMWVFFSMVFFMSILIIAQAV------------------------- ------------------------------------- >Chicken_4/1-484 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------MKRNNLSS FYVSLWLLFTATMLQAVESAKGK---------YAQ-MLFNELF-----EDYSNALRP-VEDTDK-VLNVTLQ ITLSQIKDMDERNQILTAYLWIRQSWYDAYLKWDK----DKYDGLDS-IRIP--SN---LVWRPDIVLYN-- -KAD-DDF-SEPVNTNVVLRYDGKITWDAPAITKSSCVVDVSYFPFDSQQCNLTFGSWTYNGNQVDIIN--- -------------------------SLDSGDLSDFVEDVEWEIHGMPAVKNVIT-Y-GCCSEP-------YP D----VTFTLILKRKSSFYIFNLLLPCILISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLMVAEIMP P-SENVPLIGKYYIATMTMITASTALTIIIMNVHHCGSEA-KP-VPQWARVVILDYMSKIFF---VYD---- ----------------------------------------------------------------------VG ENCTSPRREKEQEHRLEGG--------------------------------------------------DMC -----------------------RGGDGKSHLSSRNDDSDLKENLNGNW----------------------- ---------------------------------------------------------NKSFGVHGENVRENV N-----------------------------------------------------CCSCYKMLIK-NIEYIAN CVRDHKANR-AKGIEWKKVAKVMDRFFMWIFFIMVFFMSVLIIGKAA------------------------- ------------------------------------- >AnoleLizard_5/1-489 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------MNTSLAF YIFCLTCIFTTGILHGADAAQGK---------YAQ-QLFNELF-----QDYSNALRP-VEDTDS-VLNVTLQ ITLSQIKDMDERNQILAAYLWIRQSWYDAFLKWDK----DQYDGLDS-IRIP--SN---LVWRPDIVLYN-- -KAD-DDF-SEPVNTNIVLRYDGKITWDAPVITKSSCVVDVSYFPFDSQQCNLTFGSWTYNGNQVDIFN--- -------------------------SLDSGDLSDFIEDVEWEIHGMPAVRNVIT-Y-GCCSEP-------YP D----VTFTLILKRKSSFYIFNLLLPCLLISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLMVAESMP P-SENVPLIGKYYIATMTMITASTALTIIIMNIHYCGSGA-KP-VPHWARVVILDYMSKIFF---VYD---- ----------------------------------------------------------------------VG ENCTSSQHAKGQDLILKKPN-------------------------------------------------TSP ------------------KEPVQYERKSQPLANIRNHDSTLKKKFPEDV----------------------- ---------------------------------------------------------SNGYDVQGENSRDIV S-----------------------------------------------------CCSCYRILIK-NIEYIAN CVRRQKANH-AKGVEWKKVAKVMDRFFMWIFFIMVFFMSILVMGKAL------------------------- ------------------------------------- >SpottedGar_LG4_5/1-496 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MKRSIFILGFAVLCQVASCAQGK---------YAQ-MLFHDLL-----ENYSNALRP-VEDTDK-ALNVTLQ ITLSQIKDMDERNQILTAYLWIRQTWYDAYLKWDK----EAYDGLDA-IRIP--SN---LVWRPDIVLYN-- -KAD-DDF-SGPVDTNVVLRSNGEITWDSPAITKSSCVVDVSYFPFDDQQCNLTFGSWTYNGNQVDITM--- -------------------------GMDSGDLSDFVENVEWECHGMPATRNVIM-Y-GCCSDP-------YP D----ITYTLLLKRRSSFYIFNLLIPCVMISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLMVAESMP P-SENVPLIGKYYIATMTMITASTALTIFIMNIHHCGAEA-KP-VPKWAKVVIIDYMSKIFF---VYE---- ----------------------------------------------------------------------VG ENCTTPQGEKSRDVRVPAEEQ------------------------------------AAAGKGRKPPGRKTQ ------------------------SGTSRGCQSNYERCAGEEPNGNV------------------------- ---------------------------------------------------------NGCPKEDLGCPGKAQ A-------------QAQAQAQAC-------------------------------ACGRHGTVVK-NIEYIAN CFREQRATC-AKGAEWKKVAKVMDRFFMWVFFIMVFLMSILIIGKAT------------------------- ------------------------------------- >Coelacanth_scaffoldJH127267/1-463 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------AESAEGK---------YAQ-KLFSDLF-----ENYTNALRP-VEDTDK-AMNVTLQ ITLSQIKDMDERNQILTAYLWIRQIWYDAYLIWDK----DEYDGLDS-IRIP--SN---LVWRPDIVLYN-- -KAD-DEF-TGPADTNVVLRYDGQITWDAPAITKSSCVVDVAYFPFDDQQCNLTFGSWTYNGNQVDIIN--- -------------------------GMDSGDLSDFVENVEWEVHGMPAVKNVIM-Y-GCCSEP-------YP D----VTYTLLLKRRSSFYIFNLLIPCVMISFLAPLGFYLPA-DS-GEKVSLGVTVLLALTVFQLMVAESMP P-SESVPLIGKYYIATMTMITASTALTIFIMNIHHCGPEA-KP-VPQWAKVVILEYMSKIFF---VYE---- ----------------------------------------------------------------------IG ENCTSPQRTKEKHSEKHKK------------------------------------------------DEEIY ----------------------LETEGHKKSQSNGCDKCVLKELNGQSR----------------------- ---------------------------------------------------------GGSEDKHGKSEKNDL C-----------------------------------------------------FCLHHERMAK-NIDYIAT CFREQKASS-AKGTEWKKVAKVMDRFFMWVFFIMVFFMSILIIGKAV------------------------- ------------------------------------- >Amphioxus_scaffoldNW003101473_1/1-479 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------YAY-RLMQNLL-----QNYSVAVRP-SMNLSN-PIQVKFG IALSQIIDMDERNQILTAYVWLRMRWNDCSLKWNP----AEYDGLSE-LRIP--ST---HVWKPDIVLYN-- -NAD-DQF-TSRMETNVVLSHTGDIYWDSPAITKSSCEVDVSYFPFDYQNCRVTFGSWTYTIKQLEVVA--- --------------------------SEEGDLQDYIPNVEWDVLGMPAFRNLVF-Y-GCCPDP-------FP D----VTYSLKLQRKSLFYIINLIVPCVLISLLAPFSFYLPA-NS-GEKVSLGVTVLLALTVFQLLVAESMP P-SENIPLIGKYYIVTMTLMSLSTAMTIFVMNVHHCGPDR-RP-VPRWIRRFFLDTIAPILV---------- -------------------------------------------------------GEAGGRKGSVSPSGTSD TPVDITAEDTVQTVMEECELR--------------------------------------------------- -----------NQKGHMSNGVVAPAMARNLPRLSFTGFDTCKSSFLSDDVLRSRNLATDPTNNAFNVLQHKS ------------------------------------------------------------------------ ---------------------------------------------------------ELSNIAK-NVECVAN YVQGRAQEW-EIQGDWAKVAKVIDRIFMCIFIFVGAIISILILTKVI------------------------- ------------------------------------- >Amphioxus_scaffoldNW003101473_2/1-447 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MNDACRFSYACPVGVDSASGE---------FAR-KLLSDLF-----QNYTSSIRP-VRNTSR-PIDVTFG VALAQIIDMDERNQILTAYLWLRQNWVDEYLQWDP----DNYDGLES-LRVP--SH---MMWTPDIVLYN-- -NAD-DDF-SSRMETNVALDFTGHIYWDSPAITKSSCEVDVSFFPFDRQKCRLTFGSWTYSGSQIDVWN--- -------------------------ESFTGDLTDYVRNAEWELVGMPSRRNLIV-Y-GCCPDP-------FP D----VTFTIMLERKSLYYIFNLILPCMLISMLAPMSFYLPA-DS-GEKVSLGITVLLALTVFQLVVAEALP P-SENIPLIGKYYIASMTLMSLSTGMSCFVMNIHHCGPEA-RP-VPRWMRWLILKWLAQIML---FRD---- ------------------------------------------------------------------------ --------------------------------------------------------------LSITCCKNEK ----------------------KVKSRGSPRMGRSGSHTGC------------------------------- ----------------------------------------------------------------DDTTSCAR E-----------------------------------------------------RACSLEETIEKEVRYVTD RLRKKDKEN-SVAAEWQRVAKVVDRLFLWLSLLTAIAVSLLILGSYV------------------------- ------------------------------------- >C.elegans_X_1/1-557 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------ML IRFFVLCLFFILSLIIIESECSK---------AEN-KLYRDIL-----QGYLKLARP-VRYPRN-VLKVHMK VFLQQILNLDGQNQIIEVNAWLKYVWMDYRLQWDP----LQYDNITS-IRFAGGEN---QIWRPDILLYN-- -SAS-EDF-DSSFKSNEVVYNTGEVNWIPPGIFRASCKMDITYFPFDDQVCYLKFGSWTYHGLALDLSI--- -------------------IAEEDDSELSIDLSTYTPSGEWHLTKAPAVKDVK--YNSCCKEP-------YS T----VTFYMFLRRRTLFYLFNIILPSLLISIMTLMGFCLPAHDM-SEKIGYQTTILLSICFFVTIVSEMTP PTSESVPLLGMFFSSLTLISSVSTAFTITVLNFRYRQVQNIH--MHPIFYKVFLIWIPWLLL---MKR--P- --------------------------------------------------------------GVFYKKRRAT VQAREEISFFDNGDDDCCPKP------------------------------------PEFDYSLSIDSADTL PLPPRPKPLLKKMHSVPAEHLHLDRKVGDGILKSQRRPLVLTKNVNKSHSLRSRRFTQFEKYIKKCID---- ---------------------------------------------------------DAKLRKNSTYSTYSM M-----------------------------------------------------IITYYRQIDE-MLKLLNR RLDKQRKYL-FKQEDWKFAAMALDRLCLLLITLLIVMCLFGMILSTPHFEP--------------------- ------------------------------------- >C.elegans_II_1/1-538 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MMVQSI QIVLPVALFFLIVFNGFTVEGSK---------KEA-QLYRDLL-----TNYSYLVRP-VRNPKK-ALTVTMK VFIQQVLLVDAKHQMIEVNAWLKYIWTDFRLRWNP----LDYENITS-VRFQ-GED---QIWQPDILLYNRY IEDEQESF-DITYKTNAVAYSDGVINWIPPGIFKLSCKMDITLFPFDEQICFMKFGSWTYHGFALDLRL--- --------------------DVVKGQEPSADLSTYITNGEWHLLSAPARREEKF-Y-KCCKEP-------YP T----VKFYLHLRRRTFYYVFNVVLPTLLVSFMSLLAFCLPATDL-SEKIGLQTTILLSVCFFLTILSEMTP TTSEAVPLLGVFFSALTFIVAMSTTFTILVLNIRYRQITN-HY-LSPMFRSIFLECLPWLMM---MKR--P- ------------------------------------------------------------------------ DHKFRRGSSYRDSSADQCVQC----------------------------------------AKNAELKSILR GTDNQQQIETNTFYPFPTETLSLNRKVGDGLFIQRRCQIHEEARSEKFT----------------------- ---------------------------------------------------------HGMLACEKSLRENGS E-------------LANILVT---------------------------------ILKMYEVMVS-QVERIRK RIALKRKRK-DIQDEWKFAAQAVDRFCLIIFTIVFIICCF-IFVAIPPIKILD------------------- ------------------------------------- >C.elegans_III/1-469 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------M-RLYRDLL-----YDYNNEVRP-SVHSKE-PINVTFV FSLTQIIDVDERNQILTTNSWIRLHWVDYKLVWDP----RLYQNVTR-IHIP--SD---KIWKPDIILYN-- -NAD-AQYMKSVMSTDVIVDYLGNIHWPLSAIFTSSCPLDVKHYPFDRQTCILKYASWAYDGTKIDLLL--- -------------------------KSEQGDLTNYITNTEWSLIGIRAEKNQVI-Y-SCCPEP-------YP F----IDVHVTIERRAMFYVFNLILPCVLISLIALMGFYMPT-DS-GEKVTLGITSLLSTTVFLMMVAEGMP PTAEALPLIGIYFGVTIMLVALGTAMTVFTVNIHHTGVHG-YP-VPPFLQIFAFRYLSKILF---VRI---- ------------------------------------------------------------------------ -EPYHSIAHHVRYMYQKEHPT-----------------------------------------ECTLSASVHY ----------------------KRLHDFDANVAKKEEQYGLQRDMSNL------------------------ ---------------------------------------------------------SVISANVHCNPDDRL L-------------LGSQ------------------------------------SSQKNLNKFD-SEKNLRS SLSIRSGSP-TAKKKVGSIVTITLNYCLYI-LTFKITGSRSCIEYCPKYKNNGD------------------ ------------------------------------- >CionaIntestinalis_scaffoldHT000025/1-604 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------MDRR RYVMMTSLLLIVLYNLDAVNSDQ---------VEK-QLIEDIM-----MNYSKLERP-IPNHLD-TLVVNIK FTLQQIVDVDERNQIITTNAWLDLKWKDYRWRWNK----TEYGNITK-IRIP--YI---HMWTPDILLYN-- -SAD-KNF-DPTTHSPIVIDHNGNCLYVPPGIFKSTCKIDVSNFPFDEQQCTLKFGVWSYNGNQVDLQL--- ------------------------QPGGGIDATEYIESGEWHLMDLKAKRNTHK-Y-KCCPEY-------YV D----VTFTVTLRRRTMFFIINLVVPCILNSILTLLTFVLPA-GA-AEKVTLAITVLLAQIVFMLLIMETMP PTSDAIPLISKYFACSLVTVCASVAGTVLVLSFYYASPLIDGR-MSPSMRSFFLVHAPKLLR---MNPYIP- -------------------------------------------------------------KVLTAAETKPS TNQAKRKSVKPNVVARCLDRKIIQPKQDTR---------------------------IYPKVKAREKYHDVF FDALNAVDGKSPYKVRPMTNGSTGNTKSHLISNHGQNHHLITTRVRLESNENNEDSQKNNSHHRIKDTYFDI EDVSVILKEPNER--------------------------------------------QKDIERQQSTSTDNH VTKIPCSCKDRSKALRKFISD---------------------------------ENSTLDEILS-DLRRINK RKEEDELFG-EISLEWQYASRVLDKILLWVFILFVVVATLSTLFAVPNLEHVFM------------------ ------------------------------------- >C.elegans_II_2/1-500 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----MSFVFFILLTFYIQVKGSV--------DEY-RLLQYLK-----ENYDSFERP-VENSSA-PLDVKVR FLLNQIMDVDEKNQVMSILAYMDYHWNDYKLTWDP----KLFGGIRD-VRFSGDDDASFKLWRPDVLLFN-- -SVS-ESF-DSTYSSRFIVSSNGDVQQNPPGIFRFVCQIDVTYYPFDKQTCFLKLGSWTYNGQYINLDFLLT QIIGLHGIPIVVEPERSSTNYASYFVNESIDLQVYLQNGEWDLEGTPGKRVVQK---FGTDE--------YH E----LYFYIHIRRRTLAYGINLIIPSLVISMMTILGFTLPP-DA-CEKITLETTVLLSVIFFLQMVSSTSP PQSQSVPILAAFFSCCLMLVACSCVFTVLTLSLHHRKPET-HE-MSPTMRKIFIDWLPYILC---MCK--P- ------------------------------------------------------------------------ ---------------DHPKTP-----------------------------------------KPKVLGKSIA ---------------------PIHRLSTIPMLNLPRVSQTTFPDKN-------------------------- ---------------------------------------------------------VFVYHEVPAVIKNTS R-----------------------------------------------------ICAELLIIER-DIEKMLD KIEEDTKED-MLRSEWRFAAMAVDRLCLYVFSAFITMITCGLIV--PHILANI------------------- ------------------------------------- >C.elegans_V_3/1-498 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---MSVCTLLISCAILAAPTLGSL--------QER-RLYEDLM-----RNYNNLERP-VANHSE-PVTVHLK VALQQIIDVDEKNQVVYVNAWLDYTWNDYNLVWDK----AEYGNITD-VRFP--AG---KIWKPDVLLYN-- -SVD-TNF-DSTYQTNMIVYSTGLVHWVPPGIFKISCKIDIQWFPFDEQKCFFKFGSWTYDGYKLDLQP--- -------------------------ATGGFDISEYISNGEWALPLTTVERNEKF-Y-DCCPEP-------YP D----VHFYLHMRRRTLYYGFNLIMPCILTTLMTLLGFTLPP-DA-GEKITLQITVLLSICFFLSIVSEMSP PTSEAVPLLGIFFTCCMIVVTASTVFTVYVLNLHYRTPET-HD-MGPWTRNLLLYWIPWILR---MKR--P- ----------------------------------------------------------------------GH NLTYASLPSLFSTKPNRHSESLIRNIKDNE--------------------------------HSLSRANSFD -----------------------ADCRLNQYIMTQSVSNGLTSLGSIPS----------------------- ---------------------------------------------------------TMISSNGTTTDVSQQ A-----------------------------------------------------TLLILHRIYH-ELKIVTK RMIEGDKEE-QACNNWKFAAMVVDRLCLYVFTIFIIVSTIGIFWSAPYLVA--------------------- ------------------------------------- >C.elegans_X_8/1-534 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------MIS PVLRLTALHCVLFHLLTEVHSSA---------DEY-RLLADLR-----HNYDPYERP-VANASE-PLVVSVK IYLQQILDVDEKNQVITLVAWIEYQWTDYKLKWDP----SEYGGIKD-IRIPGNAN---AIWKPDVLLYN-- -SAD-ENF-DSTYPVNYVVSYTGDVLQVPPGILKLSCKIDITYFPFDDQICHLKFGSWTYSGNFIDLRI--- -----------------NGPEGKNISDEGIDVQYYVQNGEWNLLAVPARHETNI-F---DEQP-------YP S----LFFYLIIQRRTLYYGLNLIIPSFLISLMTVLGFTLPP-DA-GEKITLEITILLSVCFFLSMVADMTP PTSEAVPLIGAFFSCCMLVVSASVVFTVLVLNLHNRKPET-HE-MSPFLRELLLIWLPWLLL---MRR--P- ------------------------------------------------------------------------ ---GKTIFNCTHLKAEKAEEKAKQ--------------------------------------GSIKNGVGPG KPTDSVHPSEGLSLMKNIKLGRQQTIDFEYEFHVQHNHLMPVAPSEMTPRVTY------------------- ---------------------------------------------------------SKVMAESYVEDVVMT E-------------LNKYMQK---------------------------------ACLELKNISS-QTRAMRK KMEEDERDE-QAANDWKFAAMVVDRCCLITFSVFIVVSTCGIMFSSPHLIA--------------------- ------------------------------------- >C.elegans_I_4/1-461 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MIFNLINSILSLVIIHSNLCDGSV--------AET-KLFTDLL-----KGYNPLERP-VQNSSQ-PLEVKIK LFLQQILDVDEKNQIVSVNAWLSYTWFDHKLQWEP----KKYGGIQD-IRFPGSSD---HIWKPDVLLYN-- -SAA-EDF-DSTFKSNLLTYHTGTVVWIPPGVLKFVCQLDVTWFPFDDQVCEMKFGSWTFHGYAIDLQI--- --------------------DDDTNGTQSMDLSTYLVNGEWQVISTNAKRVVSY-Y-KCCPEP-------YP T----VNYYLHIRRRTLYYGFNLIIPSLLISLMAILGFMFPP-DA-GEKITLEVTILLAIVFFLSMVSEMTP PTSEAVPLIGVFFSCCMLVVSASVVFTIVVLNLHFRSADS-HE-MNPLVRRVLLEFLPWLLF---MSR--P- ------------------------------------------------------------------------ --------------------------------------------------------------GYKFVKANVI --------------------------DSTDKMPKKPKN---------------------------------- ---------------------------------------------------------PLDCNLPSNHAGYEA Q------------------------------------------------------ILLLHSVHT-ELRRVVA FYNKEEHDE-RIQTDWRFAAMVVDRACLLLFTVFIVISILAIMMSAPHIIA--------------------- ------------------------------------- >CionaSavignyi_reftig17/1-261 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M KVQLLAIVVPVLISLSIQDTSGSQ--------AEK-DLIDSLL-----SKYDVMVRP-TVRYTD-IINVSFA ITLQQIVDLDEKNQLLTTSMYMDWKWTDAYLTWDP----AKFDGIDE-IRLP--AK---KVWKPDILVYN-- -SAV-DSF-DQMLQTNMVVRSTGAIEWLPPGLFKTTCDVDIRYFPFDEQKCTIKFGAWTYHGGMVDLVL--- -------------------------PSEQATLDDYIPSGEWDLISMKGSRTSVK-Y-LCCPHP-------FV D----VTYTIHMRRRTLFYGFNLILPCVLVCSLTILVFLLPA-D---------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------- >CionaIntestinalis_1/1-477 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MAGGV ELFLRIVLPMLVLMTMAQGANGSQ--------AEK-DLIQDLL-----RNYDVMVRP-IDKYND-IINVSFA VTLQQIVDLDEKNQLLTTSMYMGWTWNDTYLKWNP----DNYSGIVE-IRLP--AK---KVWKPDILVYN-- -SAV-DSF-DQMLQTNVVIWSTGAVEWLPPGLFKTTCDVDIRYFPFDEQRCTMKFGAWTYHGGMVDLAL--- -------------------------PDENAILDNYIPSGEWDLISMKGHRTSVK-Y-ECCPHP-------FV D----VTYTIHMRRRTLFYGFNLILPCVLVCSLTILVFLLPA-DS-GERITLGITVLLALVVFLQLVADNLP PT-DVIPLLGKYFACSIVMVTASVVCTVISLNFHHTTSANTNT-MPGWIRFVFLNFLPRILR---MKR--P- ------------------------------------------------------------------------ --------------------------------------------------------------GENSFRRKFL ------------------------DNQAEVVMDGKVEEYPLMVAGERL------------------------ ---------------------------------------------------------GNWMGTNQTELSPLN E-----------------------------------------------------AKKELNDVLH-EVRFITS RMHNDDEDE-KSALEWRFAATVLDRFCVIFFIIYFVVSTLFTIAVAPGVLLPPDN----------------- ------------------------------------- >C.elegans_I_6/1-554 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MRRRFEIGIAFFFALFRVIWTGD---------HER-RLYAKLA-----ENYNKLARP-VRNESE-AVVVLLG MDYQQILDIDEKHQIMNSNVWLRMSWTDHYLTWDP----SEFGNIKE-VRLP--IN---NIWKPDVLLYN-- -SVD-QQF-DSTWPVNAVVLYTGNVTWIPPAIIRSSCAIDIAYFPFDTQHCTMKFGSWTYSGFFTDLIN--- ---------------------------TTISPATYKPNGEWELLGLTSQRSIFF-Y-ECCPEP-------YY D----VTFTVSIRRRTLYYGFNLLLPCMLISSLALLSFTLPA-DC-GEKLNLGVTIFMSLCVFMIMVAEAMP QTSDALPLIQIYFSCIMFQVGASVVATVIALNFHHRSPEQYKP-MNKFLKTLLLGWLPTLLG---MER--P- ------------------------------------------------------------------------ DVLELSVHGAHYASDNKKKQRQYLIEVERH------------------------ILTRPNGNGHSAVDKAVH LDLSTGNPHSDAKKSSPSPKRTSASIMGMTGLPTTQMNGALDSSINKYTCTKVTR----------------- ---------------------------------------------------------PLENGSATINHKSSP QINPINNNNIYKCANNQKTQF---------------------------------EDRHFHHILN-ELRVISA RVRKEEAMH-ALQADWMFASRVVDRVCFLAFSAFLFMCTAIISYNAPHLFV--------------------- ------------------------------------- >Fruitfly_2L_2/1-494 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MDSPL PASLSLFVLLIFLAIIKESCQGP---------HEK-RLLNHLL-----STYNTLERP-VANESE-PLEVKFG LTLQQIIDVDEKNQLLITNLWLSLEWNDYNLRWNE----TEYGGVKD-LRIT--PN---KLWKPDVLMYN-- -SAD-EGF-DGTYHTNIVVKHNGSCLYVPPGIFKSTCKIDITWFPFDDQHCEMKFGSWTYDGNQLDLVL--- ------------------------NSEDGGDLSDFITNGEWYLLAMPGKKNTIV-Y-ACCPEP-------YV D----ITFTIQIRRRTLYYFFNLIVPCVLISSMALLGFTLPP-DS-GEKLTLGVTILLSLTVFLNLVAESMP TTSDAVPLIGTYFNCIMFMVASSVVLTVVVLNYHHRTADI-HE-MPPWIKSVFLQWLPWILR---MGR--P- ------------------------------------------------------------------------ ---GRKITRKTILLSNRMKEL-----------------------------------------ELKERSSKSL --------------------------LANVLDIDDDFRHTISGSQT-------------------------- ---------------------------------------------------------AIGSSASFGRPTTVE E-------------HHTAIGC---------------------------------NHKDLHLILK-ELQFITA RMRKADDEA-ELIGDWKFAAMVVDRFCLIVFTLFTIIATVTVLLSAPHIIVQ-------------------- ------------------------------------- >Fruitfly_X_2/1-564 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------MKKPSRSRPDNPSCPGQDRTRSMSFPQPHSLPEATA NGGRMLVYGLGLLIMIPACAAGP---------HEK-RLLHALL-----DNYNSLERP-VVNESD-PLQLSFG LTLMQIIDVDEKNQLLITNIWLKLEWNDMNLRWNS----SEFGGVRD-LRIP--PH---RLWKPDVLMYN-- -SAD-EGF-DGTYATNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQL--- ------------------------QDEAGGDISSFITNGEWDLLGVPGKRNEIY-Y-NCCPEP-------YI D----ITFAILIRRKTLYYFFNLIVPCVLIASMALLGFTLPP-DS-GEKLSLGVTILLSLTVFLNMVAETMP ATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNPDT-HE-MSEWIRVIFLYWLPCILR---MQR--P- ------------------------------------------------------------------------ ---GQVGYECPPPPSSSSSSA----------------------------------------SGEKKQQIQNV ELKERSSKSLLANVLDIDDDFRCNHRCASATLPHQPTYYRTMYRQGDDGSVGPVGPAGPVV----------- ---------------------------------------------------------DGRLHEAISHTCLTS S-----------------------------------------------------AEYELALILK-ELRWITE QLKKEDETS-DITRDWKFAAMVVDRLCLIIFTLFTIIATLAVLFSAPHFIVSGVRG---------------- ------------------------------------- >Fruitfly_2L_3/1-808 MKNAQLKLTEVDDDELWLAVRLAHCSSNISSSSSTRTTSSNKRHNQQLTTLQPRSLSTKHHSNIASEQHNSQ QQEPASKDEDVANHGRSNDQQTHLQQLDSSNMLSPKTAAAATAAGDEATTQQPTNIRLCARKRQRLRRRRKR KPATPNETDIKKQQQLSMPPFKTRKSTDTYSTPAAITSCPTATYMQCRASDNEFSIPISRHDRVSTATFAWV LHVLQVLLVSLQQWQLHVQQRSVLLFRRIAASTIAFISYLGSFAAQLRSSSSSSSNSSNSGNSSSTQILNGL NKHSWIFLLIYLNLSAKVCLAGY---------HEK-RLLHDLL-----DPYNTLERP-VLNESD-PLQLSFG LTLMQIIDVDEKNQLLVTNVWLKLEWNDMNLRWNT----SDYGGVKD-LRIP--PH---RIWKPDVLMYN-- -SAD-EGF-DGTYQTNVVVRNNGSCLYVPPGIFKSTCKIDITWFPFDDQRCEMKFGSWTYDGFQLDLQL--- ------------------------QDETGGDISSYVLNGEWELLGVPGKRNEIY-Y-NCCPEP-------YI D----ITFAIIIRRRTLYYFFNLIIPCVLIASMALLGFTLPP-DS-GEKLSLGVTILLSLTVFLNMVAETMP ATSDAVPLLGTYFNCIMFMVASSVVSTILILNYHHRNADT-HE-MSEWIRIVFLCWLPWILR---MSR--P- ------------------------------------------------------------------------ --GRPLILEFPTTPCSDTSSE----------------------------------------RKHQILSDVEL KERSSKSLLANVLDIDDDFRHNCRPMTPGGTLPHNPAFYRTVYGQGDDGSIGPIGS---------------- ---------------------------------------------------------TRMPDAVTHHTCIKS S-----------------------------------------------------TEYELGLILK-EIRFITD QLRKDDECN-DIANDWKFAAMVVDRLCLIIFTMFTILATIAVLLSAPHIIVS-------------------- ------------------------------------- >Amphioxus_scaffoldNW003101420_11/1-501 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------GR---------HQR-KLLDKLL-----KNYNTLERP-VLNDSD-PLTVNLG VTLQQIIDVDEKNQILTTNIWVRMIWTDEYLSWNE----SEFGGLNQ-IRLD--PK---RIWVPDILMYN-- -SAD-ERF-DGTYPTKVVVSSSGSCLYLPPGIFKSSCKIDVTYFPFDEQRCNMKFGSWSHSGFQVDLQM--- -----------------------VNRSGGADLTPYMPNGEWDLLGMPAKRSEFK-Y-DCCPEP-------YP D----ITFTVNIRRRTLFYGTNLLVPCVLISTLTLLVFTMPP-ES-GEKLSLGITILLSLTVFLLLVAEAMP PTSDVVPLIGKYFATTLCMVAGSVVLTVLTLNFHHRSPET-SR-MSRAVRGVLLEWLPRLLC---MPS---- -----------------------------------------------------------------------R REDKSEGARDRVREALRTDNI------------------------------------SMNSFKTLDELSSHN LLASLERREVGHDFPLQAGQHDFPPGLSNDLSPRLPRNFPTALPAT-------------------------- ---------------------------------------------------------GFNIPVSATADETGL Q-------------CTRAAAR---------------------------------TSAETQQILK-ELRYIAN HFRDKSEDD-KAANEWRYAAMTVDRLCLFIFAIFTMVTTGTILLSAPHIL---------------------- ------------------------------------- >Fugu_7_2/1-571 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MLHAALWLLILASLLRVSVQGP---------QQR-FLLTELL-----KDYNPMERP-VANDSQ-ALTVQFS FILIQVMDVDEKNQIITTNAWLQMQWYDHYLQWNQ----SEYPGVKN-LRFT--PD---QVWTPDILLYN-- -SAH-DKF-DATFKANVLVNSSGYCEYLPPGIFTSTCNVDVRWFPFDIQRCELKFGSWTFDGWLLDIQM--- ---------------------------KEADVSGYMHNGEWDLLEVPGGRHEVF-Y-DCCAEP-------YP D----VTFVVTLRRRTLFYALNLLIPCVLLSSMTLLVFLLPA-NS-GEKISLGITVLLSLTVFMLMVAEIMP ATSDSVPLIGQYFASTMVIVGMSVVATVIVLQFHHHNTNN-GQ-MPRWVHLVLLQWIPWFLR---MKH--P- -----------------------------------------------------------------------G ETEEPSLPHSQTASQSRKLSSPG-------------------------------TSSSSSSSSAAARPANTD QLGLSLSRLRQHSQLNGNALYVGFQATAEPELPQRSRSVSNGRVGCGDGGEGASVERGGPSLVQRLLPSLKS EV-------------------------------------------------------PQLEGPTTPGPDASS GSSGAEAAPHPPGGLTQSPV----------------------------------VRRQLQALLA-EVQFLVE RVKEQDRQL-RLAEQWQFAASVIDRLFLVGFSVFNIICTIAILMAAPHFGEALSKDFL-------------- ------------------------------------- >Medaka_16_2/1-617 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MRKTMALWLLILATQLGVSVQGP---------HQR-YLLKELL-----RDYNPMERP-VANDSQ-ALTVHFS YTLIQVMDVDEKNQILTTNAWLQMQWYDHYLQWNQ----SEYPGVKN-LRFS--PD---QVWTPDILLYN-- -SAH-DKF-DATFKTNVLVNSSGFCEFLPPGIFVSTCSVDVRWFPFDIQRCELKFGSWTFDGWLLDIQM--- ---------------------------KEADVSGYMPNGEWDLMEVPGGRHEIF-Y-DCCAEP-------YP D----VTFVVTLRRRTLFYALNLLIPCVLLSSMTLVVFLLPA-NS-GEKISLGITVLLSLTVFMLMVAEIMP ATSDSVPLIGQYFASTMVIVGMSVVATVIVLQFHHHTPNS-GP-MPRWVHLVLLQWVPWFLR---MKR--P- -----------------------------------------------------------------------G EGAEPTLSNSQADSRSKTLSS----------------------------------PTTTTTTIPTPAPSIPP PSLSSLQASLVQLSHPLSNTLHHRSNAQAVMLPNPGHKDPSPNPHLQPNGHLPYMGFPTSAELEPLQRSRVI NNGRDNCGPVGGERDG-----------------------------------------GTNGRGGPVGDIPIH HNLQSSKLGSPPLEPPAASEPDSSTVAPVPCGLEAECGRPAALHSQSTTIRSAAVDNQLQALLV-DVQFLVE RVREQDRQV-SLAEQWQFAAAVIDRLCLVGFSVFNIICTFAILMAAPNFGIALSKDFL-------------- ------------------------------------- >Stickleback_XX_1/1-596 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------SLQGP---------HQR-LLLRELL-----RDYNPMERP-VANDSQ-ILTVQFS FTLMH--STDEKNQILTTNAWLQMQWYDHYLQWNQ----SEYPGVKN-LRFT--SD---QIWTPDILLYN-- -SAH-DKF-DATFKTNVLVNSSGFCEYLPPGIFVSTCTVDVRWFPFDIQRCELKFGSWTFDGWLLDLQM--- ---------------------------KEADVSGYMTNGEWDLLGVPGGRHEVF-Y-DCCPQP-------YP D----VTFVVTLRRRTLFYALNLLVPCVLLSSMTLVCFLLPA-NS-GEKISLGITVLLSLTVFMLMVAEIMP ATSDSVPLIGQYFASIMVIVGTSVVATVIVLQFHHHNPNS-GH-MPRWVHLVLLQWVPWFLR---MKC--P- -----------------------------------------------------------------------G EGMDPTLSGCQADFQSKTPSS--------------------------------PTTTATTTTIPTPVPPNLP QSLNSLQASLAQLNHPLPHPPPHRPNSQAVISPNPAHRDAASNPHPQPNGQLLYMGFQIFQNAAEPEPVQRS RATTQGRFTDAAG--------------------------------------------GGEGEGAEAGGGPGG DTPIHHEIQPSKFGSPPQDIPLSPDPDPFTSSGPCVPEAGVAAGRSAAVMRSVAVEHQLHALLT-EVQFLVE RVKEQDRQL-GLAEQWQFAAAVIDRLCLMGFSVFNIICTIAILMAAPNFGEALSKDFL-------------- ------------------------------------- >AnoleLizard_scaffoldGL344222/1-474 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------SQGGF---------HQR-QLLKDLM-----EDYTPLERP-VGDDAQ-PITIHFT LSLMQIMDVDEKNQVLTTNVWLQMYWYDHYLRWNE----TEYPGVKT-LRFT--PD---SVWKPDILLYN-- -SAN-EEF-DSTFHTHVLVNSSGYCQWLPPGILKSTCRIDVRWFPFDTQKCDLKFGSWTYDGWLLDLRM--- ---------------------------MESDTSGYVANGEWDLVGVPGTQNKVF-Y-ECCREP-------YL D----VTFAVTMRRRTLYYALNMLVPCLLLSAMTFLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEVMP ATSDSIPLIGQYFVMTMTMVALSVVATVFVLQYHHHDPDG-GC-MPRWVQVVVLRWGAWLLR---MRQ--P- ------------------------------------------------------------------------ -GEDPVGRPHCTPSLLSCSSESSD--------------------------------------GGGTPTPVLP ------------------------VANGGLSYGGPFPAKP-------------------------------- ---------------------------------------------------------PEVPRPFLPSPEPPA S-------------TPEELL----------------------------------SSPELGRILE-ELRYVAR CFRGRDAAQ-AACSQWKFAAAVVDRLCLVTFVLVHIVCSIGILMAAPNFAEAITKDFL-------------- ------------------------------------- >AustralianGhostshark_scaffoldNW006890074_1/1-505 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------MNA LSRYPSPACATRKYMNIDSHQGE---------YQR-KLYSELL-----KNYNRLERP-VANDSQ-PLVVDLG IAFIQIIDVDGKNQMLMTNVWLQMYWTDYYLSWNL----AENPGVRT-LRFP--SH---QVWVPDILLYN-- -SAD-DRF-DATYHTNVLVNSSGRCQYLPPGILKSTCYIDVRWFPFDIQKCELKFGSWTHNGWMIDLQM--- ---------------------------MEADISGYIPNGEWDLVGVPGKRNERN-Y-ECCEEP-------YT D----VTYTVTMRRRTLYYGLNLLIPCVLISGLALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASTMFIVGLSVVVTVLVLQFHHHDPHA-GK-MPKWVRVFLLNWCAWFLR---MKK--P- -----------------------------------------------------------------------G EGKSDIPYRYSRQQPQSISSV-----------------------------------------EMSGLSGQQT -------------------------INGNMIYFGYHTMENPCCPPSSDS----------------------- ---------------------------------------------------------GVMCGRITSSTTEDH G-------------MVQSSPPPE-------------------------------SPPEILKILE-EVQFIAK RFRDQDQGE-AISSEWKFAAAVVDRLCLVAFTVFSIVCTFAILMAAPNFIEAVSKDFA-------------- ------------------------------------- >WesternClawedFrog_1_4/1-485 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------SHQGQ---------YQR-KLYRELL-----RNYNRLERP-VVNDSQ-PLLVELQ LTLLQIIDVDEKNQVLITNAWLQITWNDFYLTWDQ----AEYPGVQT-LRFP--AD---HIWVPDILLYN-- -SAD-ERF-DATFHTNVLVNSTGACQYIPPGILKSTCYIDVRWFPFDVQKCKLKFGSWTHNGWLLDLQM--- ---------------------------MEADISSYIPNGEWDLVGVPGKRNELY-Y-ECCKEP-------YP D----VTYTVTMRRRTLYYGLNLLIPCVLISGLALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASIMVIVGLSVVVTVLVLQFHHHDPQA-GK-MPKMVRVILLNWCAWFLR---MRK--P- -----------------------------------------------------------------------G ENKRPIPCKYIYPNHHSSISSIE---------------------------------------MNIAPGHQST --------------------------NGNIVYCGYHTLESPCCPPNSDS----------------------- ---------------------------------------------------------GVMCARVNCPSLEDS D-------------LIQKKSLKE-------------------------------SMPEIVKILE-EVQYIAR RFREQDAGE-EICSEWKFAAAVIDRLCLVAFSLFAIIATFTILMSAPNFTEAVTKDFT-------------- ------------------------------------- >Chicken_Z_1/1-511 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------MLTEKCLGF FYSGLCLWASLFLSFFKVSQQGE---------SQR-RLYRDLL-----RNYNRLERP-VMNDSQ-PIVVELQ LSLLQIIDVDEKNQVLITNAWLQMYWVDIYLSWDQ----YEYPGVQN-LRFP--SD---QIWVPDILLYN-- -SAD-ERF-DATFHTNVLVNYSGSCQYIPPGILKSTCYIDVRWFPFDVQKCDLKFGSWTHSGWLIDLQM--- ---------------------------LEADISNYISNGEWDLVGVPGKRNELY-Y-ECCKEP-------YP D----VTYTITMRRRTLYYGLNLLIPCVLISGLALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASIMVIVGLSVVVTVLVLQFHHHDPQA-GK-MPRWVRVILLNWCAWFLR---MKK--P- -----------------------------------------------------------------------G ENIKPLSCKYSYPKHHPS--------------------------------------------LKNTEMNVLP ---------------------GHQPSNGNMIYSYHTMENPCCPQNNDLGSKSGKITC--------------- ---------------------------------------------------------PLSEDNEHVQKKALM D-----------------------------------------------------TIPVIVKILE-EVQFIAM RFRKQDEGE-EICSEWKFAAAVIDRLCLVAFTLFAIICTFTILMSAPNFIEAVSKDFT-------------- ------------------------------------- >AnoleLizard_scaffoldGL343339_1/1-512 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------MLSSEKGLGF VYTGLYLWASLFLSFWKVSQQGE---------NQR-RLYRELL-----KNYNRLERP-VMNDSQ-PLVVELQ LSLLQIIDVDEKNQVLITNAWLQMSWIDAYLSWDQ----YEYPGVQN-LRFP--SD---QIWVPDILLYN-- -SAD-ERF-DATFHTNVLVNYSGSCQYIPPGILKSTCYIDVRWFPFDVQKCDLKFGSWTHNGWLLDLQM--- ---------------------------LEADISNYISNGEWDLVGVPGKRNELY-Y-ECCKEP-------YP D----VTYTVTMRRRTLYYGLNLLIPCVLISGLALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASIMVIVGLSVVVTVLVLQFHHHDPQA-GK-MPQWVRVVLLNWCAWFLR---MKK--P- -----------------------------------------------------------------------G ESIRPLSCKYSHSKHQSS--------------------------------------------VSSVEMNVLP ---------------------GHQSSNGNVIYSYHAMENPCCPQNSDTGN---------------------- ---------------------------------------------------------KSGKGPDLSLEDSEI S-------------QRKALMD---------------------------------TIPVIVKILE-EVQFIAA RFRKQDEGE-EVCSEWKFAAAVIDRLCLVAFSLFAIICTLTILMSAPNFIEAVTKDFT-------------- ------------------------------------- >Medaka_10_1/1-536 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MRSRKF WVPCSVGLYIWAAFLFKGSMQGE---------YQR-KLYKELL-----ANYNRLERP-VVNDSA-AILVELG FTLLQIIDVDEKNQVLITNAWLQLHWTDIYLTWNP----ENYPGVQN-LRFP--SD---QVWTPDILLYN-- -SAD-ERF-DATFHTNVLVNASGHCQYIPPGILKSTCYIDVRWFPFDVQKCDLKFGSWTHNGWLLDLQM--- ---------------------------LDVDISTYISNGEWDLVGVPAKRNELY-Y-ECCKEP-------YP D----VTFTVTMRRRTLYYGLNLLIPCVLISGLALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASTMMIVGMSVVVTVIVLQFHHHDPHG-GK-MPKWVRVVLLNWCAWFLR---MKQ--P- -----------------------------------------------------------------------G SERKKRHYQYRHASQHHSSTS------------------------------------SIEMGTMPSLSIPLS QTSCPPCPTGTSNGSMSLYYGSYHPMDSPHCPPSSDSGVALGGQAHGSL----------------------- ---------------------------------------------------------SDEAEPTRGVSCGAG G-------------PGMGVSI---------------------------------PPPEIQHILE-EVSYIAQ RFRDQDQAE-AICSEWKFAAAVVDRLCLVAFSLFSIICTVTILMSAPNFIEAVSKDFT-------------- ------------------------------------- >Fugu_14_2/1-535 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------MRFY KFWRSVGFYICAAALFQGSLQGE---------YQR-KLYKELL-----ANYNRLERP-VVNDSA-PILVELG LTLLQIIDVDEKNQVLMTNAWLQLYWTDIYLTWNP----ESYPGVQN-LRFP--SD---QVWTPDILLYN-- -SAD-ERF-DATFHTNVLVNASGYCQYIPPGILKSTCYIDVRWFPFDVQKCDLKFGSWTHNGWLLDLQM--- ---------------------------LDVDTSTYIPNGEWDLVGVPAKRNELY-Y-DCCKEP-------YP D----VTFTVTMRRRTLYYGLNLLIPCVLISGLALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASTMMIVGMSVVVTVIVLQFHHHDPHG-GK-MPKWVRVILLNWCAWFLR---MKQ--P- -----------------------------------------------------------------------G DERKRPGYKARHLSQRHSSSS------------------------------------SIEMSAMPSLSVPLA QTSGPSCPTGTSNGSMGFYFSTYHPTDSSSCPPSSDSGVALGGRNHSSPSEEAEPPV--------------- ---------------------------------------------------------GGSGGSLGMGVGRVS I-----------------------------------------------------PPPEIMCILE-EVSYIAQ RFRDQDEAE-AICSEWKFAAAVVDRLCLVAFSLFSIICTFTILMSAPNFIEAVSKDFT-------------- ------------------------------------- >Stickleback_IV_1/1-518 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------SLQGE---------HQR-KLYKELL-----ANYNRLERP-VINDSA-AILVELG FTLLQIIDVDEKNQVLMTNAWLQLYWTDIYLTWNP----ENYPGVQN-LRFP--SD---QIWTPDILLYN-- -SAD-ERF-DATFHTNVLVNASGYCQYIPPGILKSTCYIDVRWFPFDVQKCDLKFGSWTHNGWLLDLQM--- ---------------------------LDVDTSTYIPNGEWDLVGVPAKRNELY-Y-DCCKEP-------YP D----VTFTVTMRRRTLYYGLNLLIPCVLISGLALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASTMMIVGMSVVVTVIVLQFHHHDPHG-GK-MPKWVRVVLLNWCAWFLR---MKQ--P- -----------------------------------------------------------------------G DERKRPGYKYSHSSQRHTSTG------------------------------------SLEMGTVPSLSTPLS QTSCPPCPAGASNGSMSLYFSNYHPIAGSHCPSTSDSGVALGGRPRGSLSDEAEP----------------- ---------------------------------------------------------SGGVGSGVGGLGMAV G-------------PGSAVGA---------------------------------PPPEILRILE-EVSYIAQ RLRDKDRAE-VICSEWKFAAAVVDRLCLVAFSLFSIICTFTILMAAPNFIEAVSKDFT-------------- ------------------------------------- >SpottedGar_LG4_1/1-510 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MQGRKL FGFAYIGIHIWTSYLFRESHQGE---------YQR-KLYKELL-----ENYNRLERP-VLNDSQ-PLLVELG MTLLQIIDVDEKNQVLVTNAWLQLHWTDVYLSWNT----EHNPGVQN-LRFP--SN---QIWVPDILLYN-- -SAD-ERF-DATFHTNVLVNASGSCQYIPPGILKSTCYIDVRWFPFDIQKCNLKFGSWTHNGWLLDLQM--- ---------------------------LEVDISTYIPNGEWDLVGVPGKRNEEY-Y-ECCKEP-------YP D----VTFTVVMRRRTLYYGLNLLIPCVLISGLALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASTMMIVGLSVVVTVLVLQFHHHDPHG-GK-MPKWIRVVLLNWCAWFLR---MKK--P- -----------------------------------------------------------------------G EDRKLLAYKFARPQHHCSTS-------------------------------------SIEMNAVPGQ----- ---------------------QSSNGNMNIYFGYHAMENPCCPPSSDS------------------------ ---------------------------------------------------------GVVCGRTTSSPTDDT E-----------TLHTKALSE---------------------------------HIPEIVKILE-EVQYIAR RFRDQDEGE-AICSEWKFAAAVVDRLCLVAFSLFSIICTFTILMSAPNFIEAVSKDFT-------------- ------------------------------------- >Zebrafish_1_1_chrna8/1-491 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------SLQGE---------YQR-KLYKELM-----ENYNRLERP-VLNDSA-PIVVELG LTLLQIIDVDEKNQVLITNAWLQLGWTDVYLSWNP----DNYPGVQT-LRFP--SN---QIWTPDILLYN-- -SAD-ERF-DATFHTNVLVNASGACQYIPPGILKSTCYIDVRWFPFDIQKCDLKFGSWTHNGWLLDLQM--- ---------------------------QAVDISTYIPNGEWDLVGVPGKRNELY-Y-ECCKEP-------YP D----VTFTVTMRRRTLYYGLNLLIPCVLISGLALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASTMMIVGLSVVVTVLVLQFHHHDPQG-GK-MPRWVRVILLNWCAWFLR---MKK--P- -----------------------------------------------------------------------G EERKANFKYDQSPAHHASASS------------------------------------IQMGVMPGQPSSTNS ----------------------TTNGHMNLYFGYHSIDSACCPPSSDSGV---------------------- ---------------------------------------------------------SCSGGRVGGSPNEEQ R-------------EGVRMFA---------------------------------GEPEIHRILA-EVMYIAQ RFRDQDEAE-AICSEWKFAAAVVDRLCLVAFSLFSIICTFTILMSAPNFIEAVSKDFT-------------- ------------------------------------- >Fugu_17_5/1-520 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------MSRNSCPTAVMEPRKR SGSVLIGVYLWATFCSQGGHGGP---------FQR-KLYHDLM-----VNYNRLERP-VLNDSA-PIVVELG FTLRQIIDVDEKNQVLITNAWLQLYWTDIYLSWNP----ESFPGVQN-LRFP--SS---LIWMPDILLYN-- -SAD-ERF-DATFHTNVLVNATGVCQYIPPGILKSTCYIDVRWFPFDVQRCDLKFGSWTHNGWLLDLQM--- ---------------------------MDVDISTYIPNGEWDLVGVPAKRNELY-Y-DCCKEP-------YP D----VTFTVTIRRRTLYYGLNLLVPCVLISGLALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASTMMIVGLSVVVTVLVLQFHHHDPHG-GK-MPKWVRVVLLNWCAWFLR---MKK--P- ------------------------------------------------------------------------ -GEDKQAVASSRPPDHKRSHP-----------------------------------------PPHASASTIQ -----------VATIPGQAPAPTANGNMNLYFSYHALALDNPTLPPAS------------------------ ---------------------------------------------------------DPSVIRSEQTRSLLL E-----------------------------------------------------QLPEISQILE-EVQYIAR RFREQDEGE-AICSEWKFAAAVVDRLCLVAFSLFSIICTFTILMSAPNFIEAVFKDFT-------------- ------------------------------------- >Stickleback_IX_5/1-529 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MEPRRC AGPVLIGVYLWTTFCCKGCHGGV---------YQR-KLYRDLM-----VNYNRLERP-VQNDSA-PIVVELG LTLLQIIDVDEKNQVMITNAWLQLHWTDIYLSWNQ----ESYPGVQN-LRFP--SN---LVWVPDILLYN-- -SAD-ERF-DATFHTNVLVNASGSCQYIPPGILKSTCYIDVRWFPFDVQKCDLKFGSWTHDGWLLDLQM--- ---------------------------MDVDISTYIPNGEWDLVGVPAKRNELY-Y-DCCKEP-------YP D----VTFTVTMRRRTLYYGLNLLIPCVLISGLALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASTMMIVGLSVVVTVLVLQFHHHDPYG-GK-MPKWVRVILLNWCAWFLR---MKK--P- -----------------------------------------------------------------------G EENKTAVSSGCAADYKNCHYP--------------------------------------PEHSSSGSIQMSL VPGQASTQPSTTNGNANLYRGYHPRSSDNHSFPPSTDSGAVMCGGGHLNGS--------------------- ---------------------------------------------------------SPHEIHLEQTRTLLL E-----------------------------------------------------QVPEISRILE-EVHYIAR RFREHDEGE-AICSEWKFAAAVVDRLCLVAFSLFSIICTFTILMSAPNFIEAVSKDFT-------------- ------------------------------------- >Medaka_1_5/1-527 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MEPQRR AASLLLGVSLCAAFCCQECHGGV---------YQR-KLYRDLM-----VNYNRLERP-VQNDSA-PIVVELG ITLLQIIDVDEKNQVLITNAWLQMYWTDIYLSWSP----ESYPGVQN-LRFP--SN---MVWVPDILLYN-- -SAD-ERF-DATFHTNVLVNSSGYCQYLPPGILKSTCYIDVRWFPFDVQKCDLKFGSWTHNGWLLDLQM--- ---------------------------MDADISTYIPNGEWDLVGVPAKRNELY-Y-DCCKEP-------YP D----VTYTVTMRRRTLYYGLNLLIPCVLISGLALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASTMMIVGLSVVVTVLVLQFHHHDPRG-GK-MPKWVRVVLLNWCAWFLH---MKK--P- ------------------------------------------------------------------------ --GEDRKTAVSSQTYKYCSSP---------------------------------------HHTSSSSIQMST IPGQPSTQATSTNGNMNLYFGYHSMGTENPAFPLGSNSSVMVCGG--------------------------- ---------------------------------------------------------GDGGNHLNGSSQLDL D-------------QTRTLLLE--------------------------------QVPEITQILA-EVQYIAR RFREQDEGE-EICSEWKFAAAVVDRLCLVAFSLFSIICTFAILMSAPNFIEAVSKDFT-------------- ------------------------------------- >Stickleback_II_4/1-510 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M DSLHLLLFLAVAALAVQVSLQGP---------GER-RLFKDLM-----TDYNPLERP-VSNDSQ-NLTVELG LSLIQIIDVDEKNQVLTTSIWLQMQWEDSYLRWNA----SDYTGVTN-IRFP--QD---LLWKPDILLYN-- -SAD-ENF-DATSHTKILVNTSGNCFHLPPGILKSSCRMDLRWFPFDVQKCELKFGSWTYGGWSVDLKL--- ---------------------------LQADTSSYIPNGEWDLVEIKGQRNEHT-Y-VCCEEP-------YP D----ITYTLVMRRRTLFYGLNLLLPCVLISTLALLVFLLPA-DS-GEKISLGITVLLSLAVFMLLVAEIMP ATSDSVPLLAQYFATIMVIVGLSIMATVVVLQYHHHDPDG-GK-MPKWTRVILLNWCAWFLR---MKR--P- ------------------------------------------------------------------------ --------------------------------------------------------------GEGRPGPARH DEAPQNSVTGVTSVDLGAGAPAPQSTNGKLLYVGIRGLDSIKYAATSPDS---------------------- ---------------------------------------------------------GVLCARLAGGAGEDE L--------LLPAGHGSPAGS---------------------------------VEPELAKILE-EVRYIAK RFRHQDDDK-SVCNEWKFAASVIDRLCLLAFSLFTILFTIGILMSAPNFVDAVSKDFS-------------- ------------------------------------- >Fugu_13_4/1-302 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MWNAQIFLMVLAFSIKDTVQGP---------TEE-RLYNYLL-----RRYNSMIRP-VANDSE-TLMVRLG LSLMQIMDVDEKNQILTTNVWLQMEWTDSYLTWDV----SEYPGINS-LRLP--SR---NIWKPDILLYN-- -SAD-ERF-DATYHTNVVVVPSGNCTYVPPGILKSTCHIDVRWFPFDVQKCDLKFGSWTHGIWTLDLQM--- ---------------------------LEADISSYIPNGEWDLLEVKGRVNQRK-Y-DCCEET-------YP D----VTFTVVMQRRTLYYGINLLLPCVLISTLALLVFVLPA-DS-GEKISLGITVLLSMTVFMLMVAEIMP ATSESVPLIAQYFAAIMVIV---------------------------------------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------- >SpottedGar_LG3_5/1-456 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M GTWGMLLHLTCLACWLDVSLQGE---------FQR-KLYKDLM-----KNYSPLERP-VSNDSH-PLTVYFS LSLMQIMDVDEKNQVFTTNIWLQLYWNDFYLQWNA----SDYPGVKN-VRFP--DE---QIWKPDVLLYN-- -SAD-ERF-DATFHTNVLVNSTGYCQYIPPGIFKSTCYIDVRWFPFDVQRCDLKFGSWTYGGWSLDLQM--- ---------------------------LEADTSEYIPNGEWDLVGVQGRRNERF-Y-ECCEEP-------YP D----VTFTVVMRRRTLYYGLNLLIPCVLISTLALLVFLLPA-DS-GEKISL-------------------- ----------QYFASTMIIVGLSVIVTVWVLQFHHHDPDG-GK-MPKWTRTILLNWCAWFLR---MRR--P- -----------------------------------------------------------------------G EEKVRSACHHSQQ-------------------------------------------------RGSVCSVELG -------------------------ANGGLAYLGTRGLEGARYGAAAEP----------------------- ---------------------------------------------------------GLGVAEEDLLLPGAH G-----------------------------------------------------VEHELAKILE-EVRYISG RFRAQDEDG-SICSEWKFAASVIDRLCLMAFSVFTILCTIGILMSAPNFVEAVSKDFT-------------- ------------------------------------- >Medaka_6/1-516 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M DAKTVSLLILSFCCFICGSLQGV---------HQR-RLYKELI-----RNYNPLERP-VSNDSH-SLTVHFS FSLLQIMDVDEKNQVLTTNIWLQLYWKDFYLQWNM----SDYPGVTN-VRFP--DS---QIWRPDILLYN-- -SAD-ERF-DASFHTNILVNSSGYCQYLPPGIFKSTCHIDVRWFPFDVQRCDLKFGSWTYGGWSLDLQM--- ---------------------------INADTTGYIANGEWDLVEVPGQRSERF-Y-DCCKEP-------YP D----VTFTVVMRRRTLYYGLNFLIPCVLISTLALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFATTMAIVGLSVIATVLVLQYHHHDPDG-GH-MPQWTRVVLLNWCAWFLR---MRR--P- -----------------------------------------------------------------------G EAKVLLACHNMGKRQRGSLSS-----------------------------------LELSINPVSVPPQPHV -------------------------TNSNLLYVGFQGVEGLHCGSATDPEPLCARFIE-------------- ---------------------------------------------------------EDFLRVGGGTRRRQG G-------------VLNDSA----------------------------------LEVELQQILE-EVRFIGQ RFRNQDQEK-AACSEWKFAAAVIDRLCLVAFSVFTILCTIGILMSAPNFVEAISKDFFS------------- ------------------------------------- >AustralianGhostshark_scaffoldNW006890058_1/1-501 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M TLRDCALWIFVFISLLHVSRQGE---------YQR-KLYRELM-----RNYNSLERP-VANDSL-PLTVHLT LGLMQIMDVDEKNQVLTTNVWLQMQWNDYYLQWNV----SEYPGVKN-VRFP--DV---NLWTPDILLYN-- -SAD-DRF-DATFHTNVLVNSTGHCQWIPPGIMKSSCYIDVRWFPFDIQRCDLKFGSWTYDGWLLDLQM--- ---------------------------LDADISGYIPNGEWDLVGMPGERTESF-Y-ECCQEP-------YP A----VTFTVVMRRRTLYYGLNLLIPCVLISGLALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASTMIIVGLSVVVTVFVLQYHHHDPDG-GK-MPNWTRNILLNWCAWFLR---MKR--P- -----------------------------------------------------------------------G EDKVRSACNQKQRRCSVS--------------------------------------------SVEMNTVPGQ -----------------------QSVNGNLLYIGYRGMGGIHCTPTTDDS---------------------- ---------------------------------------------------------GVICGRIDCPPTEDD H-------------LIHNCHP---------------------------------SDPELSKILD-EVRYIAT RFRDQDEND-SICNEWKFAASVVDRLCLVAFSVFTIILTIGILMSAPNFVEAVSKDFA-------------- ------------------------------------- >Coelacanth_scaffoldNW005821866/1-514 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------MQESTKLEDFLKN FSRGDMSPGTSKAVLVHVSLQGE---------FQR-KLYKELL-----KNYNPLERP-VGNDTQ-PLTVYFT LSLMQIMDVDEKNQVLTTNIWLQMNWIDYYLSWNV----SEYVGVKN-VRFP--DG---VIWKPDILLYN-- -SAD-EKF-DATFHTNTLVNSTGGCQYIPPGIFKSSCYIDVRWFPFDVQKCDLKFGSWTYDGWSLDLQM--- ---------------------------QEADISGYIPNGEWDLVGVPGKRSETF-Y-ECCKEP-------YP D----VTFTVVMRRRTLYYGLNLLIPCVLISALALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASTMIIVGLSVVVTVLVLQYHHHDPDG-GK-MPKWTRIILLNWCAWFLR---MKR--P- -----------------------------------------------------------------------G EDKVRSVCKHKQRRCSLS--------------------------------------------SVEMNTVSGQ -----------------------QSSNGNMLYLGFKGLDGLHCTPTTDS----------------------- ---------------------------------------------------------GVICGRVTCSPTEDD H-------------LVHNGPPSD-------------------------------GDPDLVKILE-EVRYIAN RFRDQDEGE-AICNEWKFAASVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA-------------- ------------------------------------- >WesternClawedFrog_3_4/1-502 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M GRGEFTVWMIIAVCFMNVSLQGE---------YQR-KLYKELM-----KNYNPLERP-VLNDSH-PLTVYFG MSLMQIMDVDEKNQVLTTNIWLQMQWIDYYLQWNM----SEYPGVKN-VRFP--DG---QIWKPDILLYN-- -SAD-ERF-DASFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDIQKCNLKFGSWTYGGWSLDLQM--- ---------------------------LESDISEYISNGEWDLVGVPGKRSENY-Y-ECCKEP-------YL D----VTFTIIMRRRTLYYGLNLLIPCVLISALALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPHG-GN-MPKWTRIILLNWCAWFLR---MKR--P- -----------------------------------------------------------------------G EDKVRPVCQHKERRCSMT--------------------------------------------SVDVNTVSGQ -----------------------QSSNGNMLYIGFRGLEGIHCTPTPDS----------------------- ---------------------------------------------------------GVICGRMTCSPTDDE N-------------LLHNVHHSE-------------------------------GDPDLSKILE-ELRYIAN RFRDQDDDE-SICNEWKFAASVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA-------------- ------------------------------------- >Mouse_7_1/1-502 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M CGRRGGIWLALAAALLHVSLQGE---------FQR-RLYKELV-----KNYNPLERP-VANDSQ-PLTVYFS LSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNM----SEYPGVKN-VRFP--DG---QIWKPDILLYN-- -SAD-ERF-DATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQM--- ---------------------------QEADISSYIPNGEWDLMGIPGKRNEKF-Y-ECCKEP-------YP D----VTYTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASTMIIVGLSVVVTVIVLRYHHHDPDG-GK-MPKWTRIILLNWCAWFLR---MKR--P- -----------------------------------------------------------------------G EDKVRPACQHKPRRCSLA--------------------------------------------SVELSAGAGP -----------------------PTSNGNLLYIGFRGLEGMHCAPTPDS----------------------- ---------------------------------------------------------GVVCGRLACSPTHDE HLMHGTHPSD--------------------------------------------GDPDLAKILE-EVRYIAN RFRCQDESE-VICSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA-------------- ------------------------------------- >Human_15_1_CHRNA7/1-502 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M RCSPGGVWLALAASLLHVSLQGE---------FQR-KLYKELV-----KNYNPLERP-VANDSQ-PLTVYFS LSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNV----SEYPGVKT-VRFP--DG---QIWKPDILLYN-- -SAD-ERF-DATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQM--- ---------------------------QEADISGYIPNGEWDLVGIPGKRSERF-Y-ECCKEP-------YP D----VTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDG-GK-MPKWTRVILLNWCAWFLR---MKR--P- -----------------------------------------------------------------------G EDKVRPACQHKQRRCSLA--------------------------------------------SVEMSAVAPP -----------------------PASNGNLLYIGFRGLDGVHCVPTPDS----------------------- ---------------------------------------------------------GVVCGRMACSPTHDE H-------------LLHGGQPPE-------------------------------GDPDLAKILE-EVRYIAN RFRCQDESE-AVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA-------------- ------------------------------------- >Opossum_1_4/1-502 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M SRQQGSVWLVVAASLLHASLQGE---------FQR-KLYKELL-----KNYNPLERP-VANDSQ-PLTVYFS LSLLQIMDVDEKNQVLTTNIWLQMYWTDYYLQWNM----SEYPGVKN-VRFP--DG---QIWKPDILLYN-- -SAD-ERF-DATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDLQM--- ---------------------------QEADISGYISNGEWDLVEIPGKRSERF-Y-DCCKEP-------YP D----VTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASTMIIVGFSVVVTVIVLQYHHHDPDG-GK-MPKWTRIILLNWCAWFLR---MKR--P- -----------------------------------------------------------------------G EDKVRPACQHKQHRCSLT--------------------------------------------SVELNAMSGQ -----------------------PTSNGNMLYIGFRGLEGTHCMPASDS----------------------- ---------------------------------------------------------GVICGRMTCSPTEEE NILHSGHTSE--------------------------------------------GDPDLAKILE-EVRYIAN RFRDQDEEE-AVCNEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA-------------- ------------------------------------- >Chicken_10_4/1-502 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M GLQALMLWLLAAAGLVRESLQGE---------FQR-KLYKELL-----KNYNPLERP-VANDSQ-PLTVYFT LSLMQIMDVDEKNQVLTTNIWLQMYWTDHYLQWNV----SEYPGVKN-VRFP--DG---LIWKPDILLYN-- -SAD-ERF-DATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQKCNLKFGSWTYGGWSLDLQM--- ---------------------------QEADISGYISNGEWDLVGIPGKRTESF-Y-ECCKEP-------YP D----ITFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDG-GK-MPKWTRVILLNWCAWFLR---MKR--P- -----------------------------------------------------------------------G EDKVRPACQHKQRRCSLS------------------------------------------SMEMNTVSGQQC -------------------------SNGNMLYIGFRGLDGVHCTPTTDS----------------------- ---------------------------------------------------------GVICGRMTCSPTEEE N-------------LLHSGHPSE-------------------------------GDPDLAKILE-EVRYIAN RFRDQDEEE-AICNEWKFAASVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA-------------- ------------------------------------- >AnoleLizard_scaffoldGL343486/1-421 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------WTDYYLQWNM----SDYPGVKN-VRFP--DG---LIWKPDILLYN-- -SAD-ERF-DATFHTNVLVNSSGYCQYLPPGIFKSTCSIDVRWFPFDVQKCKLKFGSWTYGGWSLDLQM--- ---------------------------QEAEISGYISNGEWDLVGVPGKRTETF-Y-DCCKEP-------YP D----VTFTVTMRRRTLYYGLNLLVPCVLISALALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDG-GK-MPKWTRIILLNWCAWFLR---MKR--P- -----------------------------------------------------------------------G EDKVRPACQHKQRRCSMS--------------------------------------------SVEINTVSGQ -----------------------QSSNGNMLYIGFRGLEGVHCTPTTDS----------------------- ---------------------------------------------------------GVICGRMTCSPTDDD N-------------LLHSGHPSE-------------------------------NDPDLAKILE-EVRYIAN RFRDQDEAE-AVCNEWKFAASVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA-------------- ------------------------------------- >Medaka_3_1/1-531 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------MIPPAAAIICGIAPCPRVSFNM DLRDLLLFVAVAACAVKVSHQGP---------NQR-RLYSDLM-----STYNPLERP-VYNDSQ-SLTVHFG LSLLQIMDVDEKNQVLTTNIWLRLYWNDHYLQWNS----SDYPGVTN-VRFP--DH---LIWKPDILLYN-- -SAD-ERF-DATFHTNILVNSSGTCSYLPPGIFKSTCYIDVRWFPFDVQRCELKFGSWTYGGWSLDLKM--- ---------------------------LEADVSGYIANGEWDLVEVPGQRNERF-Y-ECCDEP-------YL D----ITFTVVMRRRTLYYGLNLLLPCVLISTLALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAEYFATTMVIVGLSVIATVLVLQYHHHDPDG-GK-MPKWTRVILLNWCAWFLR---MKR--P- -----------------------------------------------------------------------G EDRVRSACDNKTRRSSLT--------------------------------------------SMDLNAPTST ----------------------SLSTNGNLLYVGVRGLESLQYSPGATSPDS-------------------- ---------------------------------------------------------GVVCGRLITRAGEDE M--------LLPSSHASSLGN---------------------------------MEMELAKILD-EVRYIAK RFRDQDEDE-SVCNEWKFAASVVDRLCLMAFSLFTILCTIGILMSAPNFVEAISKDFFS------------- ------------------------------------- >Zebrafish_7_3_chrna7a/1-509 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M GIWEYTLYFTTTCCLWRVSLQGE---------HQR-RLYRDLM-----KDYNPLERP-VFNDTH-SLTVYFS MSLMQIMDVDEKNQVLTTNIWLQLYWYDYYLQWNA----SEYPGVTN-VRFP--DS---QIWKPDILLYN-- -SAD-ERF-DATFHTNVLVNSSGACQYLPPGIFKSTCYIDVRWFPFDLQRCDLKFGSWTYGGWSLDLQM--- ---------------------------IDADITGYIANGEWDLVEVPGRRNERF-Y-DCCKEP-------YP D----VTFTVVMRRRTLYYGLNLLIPCVLISTLALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFATTMVIVGLSVIATVWVLQYHYHDPEG-GK-MPKWTRVVLLNWCAWFLR---MKR--P- -----------------------------------------------------------------------G EDKVRPACHNKQPRSSLS--------------------------------------------SVDLNISPGV ----------------------AQSTNGNLLYIGFRGMDTIHYATSPDSGVICSRLVATGEED--------- ---------------------------------------------------------VLLPGAQASSVSSSG P-----------------------------------------------------GETELSKILD-EVRYISK RFRDQDEED-TVCNEWKFAASVIDRLCLMAFSLFTILCTIGILMSAPNFVEAISKDFFT------------- ------------------------------------- >Zebrafish_25_chrna7b/1-545 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------MRVTVRQRARVCVGVSCVSSGDSCSLGAGVSV MGSGGTLALLSAALLLHVSLQGE---------HQR-RLYRDLM-----KNYNPLERP-VYNDSH-SLTVHFS FSLMQIMDVDEKNQVLTTNIWLQLYWTDYYLRWNM----SDYPGVNT-VRFP--DS---LIWRPDILLYN-- -SAD-ERF-DATFHTNVLVNSSGYCQYLPPGIFKSTCYIDVRWFPFDVQRCDLKFGSWTYGGWALDLQM--- ---------------------------INADITGYIANGEWDLVEVPGRRNEKF-Y-DCCKEP-------YP D----VTFTVVMRRRTLYYGLNLLIPCVLISTLALLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIAQYFATTMVIVGLSVIATVLVLQYHYHDPDG-AK-MPKWTRVLLLNWCAWFLR---MRR--P- -----------------------------------------------------------------------G EDRIRLACHNKPARRSSVS-------------------------------------------SVELSVSQGA ----------------------LQAAGGNMLYFGFRGMEGVHYTAHESHSVLCSRLMANSEDDVLLP----- ---------------------------------------------------------GAQIRGGVTSGIVGG T-----------------------------------------------------LELELAKILE-EVRYIAK RFRDQDADE-SVCNEWKFAAAVIDRLCLMAFSIFTILCTIGILMSAPNFVEAISKDFFT------------- ------------------------------------- >AustralianGhostshark_scaffoldNW006890372/1-446 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------SQQGE---------GQR-RLYRELM-----KDYNPLERP-VWNDSV-SLRVTFS ISFLQILDVDEKNQILTTNFWLHMTWFDHYLRWNE----SEFPGVKN-VRFR--AD---QVWTPDILLYN-- -SAD-DDF-DSTYKPHVLVNSTGYCTFMPPGIFRSSCQVDVRWFPFDTQECELKFGSWTYDGWLLDLRM--- ---------------------------SPADLSGFIPNGEWDLLGVPGQRHEVF-Y-ECCPEP-------FP D----VTFYVTIRRRTLYYALNLLVPCVLLSSMTLLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSIPLIGQYFASTMIIVGMTVIATVVVLQYHHHNPTG-GK-IPKWTRVLLLTWGAWCLR---MKK--P- ------------------------------------------------------------------------ --------------------------------------------------------------GGPREDLVSH -----------------------HPPCQRRRSSASEGYPG-------------------------------- ---------------------------------------------------------ISGEGFLGPDPTQGV T-----------------------------------------------------GGPELTRLLQ-EVEYLTE REREREKEE-EEREEWRFAAAVMDRMCLVGFSIFNILSTISILMSAPSFGDALAKDFL-------------- ------------------------------------- >Coelacanth_scaffoldNW005822901/1-502 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M MRIQDYLNLAGIVLLIQDSHQGP---------YQR-KLIKELM-----KDYSTLERP-VGNDSQ-MLTVHFS LSLMQIMDVDEKNQILTTNIWLQMYWYDHYLRWNQ----SEYPGVKN-IRFP--SD---QVWRPDVLLYN-- -SAD-DNF-DATYHTNILVNSSGYCSWLPPGIFTSSCNIDVRWFPFDVQNCELKFGSWTYDGWLLDLQM--- ---------------------------TDADISGYMPNGEWDLVGVSGTRNEIF-Y-DCCKEP-------YP D----VTFYVTIRRRTLYYALNLLIPCVLLSTMTLLVFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSIPLIGQYFASTMIIVGLSVVATVFILQYHHHDPSG-GK-MPKWVRVFILKWCAWFLR---MKK--P- -----------------------------------------------------------------------G EQDEERPQCAPSLHGCSSE-------------------------------------------SEQTTPDRHS -------------------------ANRNMLYIGFQGMEDLPRPPTKKSDLL-------------------- ---------------------------------------------------------QKQPSYPSAHINGVL P-------------CSSSPEQ---------------------------------ADPQLEKILE-EIRYIAD RFREQDSDE-LICNDWKFAAAVIDRLCLVAFAVFNILCTISILMSAPNFVEAMSKDYI-------------- ------------------------------------- >SpottedGar_LG24/1-446 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MLTSLLLHLASAAALIRVSEQGP---------HQR-TLLKELL-----KDYNRMERP-VGNDSL-PLTVHFT LSLMQIMDV--------------------------------------------------------------- ------------------------------------------------------------------------ --------------------------------------------VVPGNRNEIF-Y-DCCKEP-------YP D----VTFVVTIRRRTLYYALNLLIPCVLLSSMTLLVFVLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSIPLIGQYFASTMIIVGMSVVATVVVLQYHHHDPSG-GR-MPKWVELILFQWVAWFLR---MKR--P- -----------------------------------------------------------------------G EEGLPERPPCTPNLRRCSSGSGTGSLHCSP---------------------------NPDPILHPLHPQNLP SLSPHAQLHAQLHGLHPSHGSTHNGNLLYLGFQNLDDPPVITAPQRPPRKGGPGSSGSPPPHVPPQFGSPLP HLQAMGVPSLNGESVGGG---------------------------------------STLSAGCGGAPGGGC L-------------GVCPAGI---------------------------------GDPQLQAILE-EVRFIAD RFREQDEGE-TECEQWKFAAAVIDRLCLVAFSIFNIVCTISILMSAPNFVEAVSKDFI-------------- ------------------------------------- >Zebrafish_19_chrna11/1-589 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MWHSLAFTLCGISALIQVSVQGP---------YQR-TLLKNLL-----KDYNRMERP-VANDSQ-PLTVFLS MSLIQIMDVDEKNQVLTTNIWLNMHWYDHYLQWNQ----SEYPGVKN-LRFT--TD---QVWTPDILLYN-- -SAD-DKF-DSTFKSNVVVNSSGYCNYLPPGIFMSTCNVDVRWFPFDIQKCELKFGSWTFDGWLLDLQM--- ---------------------------NEADISGYMPNGEWDLVGVPGTRNELF-Y-DCCKEP-------YP D----VTFVVTIRRRTLYYALNLLIPCVLLSSMTLLIFLLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSIPLIGQYFASIMIIVGMSVIATVVVLQYHHHDPNG-GN-MPKWVQLVLLQWVAWFLR---MKR--P- -----------------------------------------------------------------------G ESEDPERPPCAPHLRRCSSGS------QSGSLPNAPGSASADLHHHHISSTLHPLHPQSLLQAAAAAGHTHH LHNQTNSANNNGNLLYIGFSSLDEASPPALLADSVQRNSMSGGPRPTVVSPPVVGSSPPPHLPSQFCSPPPP PTPNLEA--------------------------------------------------TGCPSTVSGGGGGCS C-------------SGTSGG----------------------------------GDPQLQAILE-EVRYVAD RFRGQDENE-SVTEQWKFAAAVIDRLCLVAFSVFNIICTISILMSAPNFVEAVSKDFI-------------- ------------------------------------- >Fugu_12/1-573 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MWQSPALLFSGLAALIHVSLQGP---------HQR-TLLKNLL-----KDYNRMERP-VANDSQ-PLTVVFT LSLIQIMDVDEKNQILTTNIWLRMSWFDHYLQWNQ----SEHPGVKN-LRFT--TD---QIWTPDILLYN-- -SAD-DDF-DSTFKTNVLVNSSGYAEYQPPGIFMSTCNVDVRWFPFDIQRCELKFGSWTYDGWLLDLQM--- ---------------------------NEADISGYMANGEWDLIGVPGTRNEVF-Y-DCCKEP-------YP A----VTFVVAIRRRTLYYALNLLIPCVLLSSMTLLIFVLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIGQYFASIMIIVGMSVVATVVVLQYHHHDPNG-GN-MPKWVQLVLLQWVAWFLR---MKR--P- -----------------------------------------------------------------------G EKDSPERPPCAPHLRRCSSGS------QSG---------------------------SIPNPPDHALHPLHP QGLAPLQPGGLHAGQPHVHAQSSANNNGNLVYLGFQSVEDSAGLPEPIQRNNISTGPPRVAGSPPPHLPSQF CSSPPPPASNMDTGCPS----------------------------------------TVSSGGGFGGGGGGL G-------------GCSASAV---------------------------------GDPQLHAILE-EVRFVAD RFREQDEVS-GAADQWKFAGAVIDRLCLVAFSVFNIICTISILMSAPNFVEAISKDFV-------------- ------------------------------------- >Medaka_11/1-573 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------MHL ITKPRHLFCGLTFSPSSVSLQGP---------HQR-SLLKSLL-----KDYNRMERP-VANDSH-TLTVHFT LSLIQIMDVDEKNQVLTSNMWLQMTWYDHYLQWNQ----SEYPGVKN-LRFT--SD---QVWTPDILLYN-- -SAD-DDF-DSTFKTNVLVNSSGYAKYLPPGIFMSTCNVDVRWFPFDIQKCNLKFGSWTYDGWLLDLQM--- ---------------------------IEADISSYMPNGEWDLIGVPGSRNEIF-Y-DCCKEP-------YT D----VTFVITIRRRTLYYALNLLIPCVLLSSMTLLVFVLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIGQYFASIMIIVGMSVIATTVVLQYHHHDPNG-GN-MPKWVQLVLLQWVAWFLR---MKR--P- -----------------------------------------------------------------------G ESDDPERPPCAPHLRRCSSGS------QSG---------------------------SIPNPPDHTLHPLHP QSLAPLQTGPLHVGHPHLHTQSTTNNNGNLLYMGFQSIEDSSVLSEPVQRNVSAGPPRVAGSPPPHLPSQFC SSPPPPASNMDTVA-------------------------------------------CPSTVSSGGGFGGGV G-------------GCSTAGI---------------------------------GDPQLQAILE-EVRYMAD RFREQDEAE-SVANQWKFAGAVIDRLCLVAFSVFNIICTISILMSAPNFVEAVSKDFV-------------- ------------------------------------- >Stickleback_X/1-551 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------SLQGP---------HQR-SLLKNLL-----KDYNRMERP-VGNDSQ-PLTVVFT VSMIQIMDVDEKNQVLTTNMWLRMSWFDHYLQWNQ----SEHPGVKN-LRFT--TD---QIWTPDILLYN-- -SAD-DDF-DSTFKVNVLVNSSGYAEYLPPGIFMSTCNVDVRWFPFDIQKCELKFGSWTYDGWLLDLQM--- ---------------------------EDADISGYMPNGEWDLIGVPGSRNEAY-Y-DCCKEP-------YQ D----VKFIVTIRRRTLYYALNLLIPCVLLSSMTLLIFVLPA-DS-GEKISLGITVLLSLTVFMLLVAEIMP ATSDSVPLIGQYFASIMIIVGMSVIATVVVLQYHHHDPNG-GN-MPKWVQLVLLQWVAWFLR---MKR--P- -----------------------------------------------------------------------G ESDDPERPPCAPHLRRCSSGS------HSG--------------------------------SIPNPPDPTL HPLHPQNLAPLHAVHPHLHAQSSANNNGNLLYMGYQSMEDPSILSEPLQRNNISVGPARVPGSPPPHLPSQF CSSPLPPIPNMDTLGCPS---------------------------------------TVSSGGGFGGGAGGL G-------------GCPAAGI---------------------------------GDAQLQAILE-EVRYMAD RFREQDETE-SVADQWKFAAAVIDRLCLVAFSVFNIICTISILMSAPNFADAISKDFI-------------- ------------------------------------- >CionaIntestinalis_7_3/1-506 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------MTTT VLIVILFCLLDLSASLKNSTFFS---------KEA-ELVSILL-----DGYSARVRP--RDKNG-KTKVNVG ITLSQIMSLSEKSEVMMSSMYMTYTWVDPRFSWNE----SKYDGILV-TRIS--VD---RIWVPNIIIKN-- -SKE-RNL-KESLRVNALVFHNGSVQWLPPAIYKTSCTMDVTLFPFDWQNCSMVFRSADHDQSEMIFGL--- ----------------------SYGSSIWVDKHVYIKNGEWVLYQKPAYVVKKK-----SDEQ-------FQ E----VWFTVILCRKPQFYVLNMLLPCVMISILSCFVFHLPV-VA-GEKIGLSISLLLGDTIFVFLFAQRMP STALTVPHVATYLLFSMILLFLSIFCCVVVYNFHFRSNVT-HE-MPRVWKWLFFDKFAPLLG---LQQ--P- ------------------------------------------------------------------------ HRKEKVQSNKFAETSSSRNDF-----------------------------------------IAKTISQNYM ----------------------MQKSPSEQMYLTQAPLYGFRSRQKRL------------------------ ---------------------------------------------------------VDINGGLSAIPIAIK P-----------------------------------------------------VSESIKTALR-ETENVTA HFKKIKAQR-RARHDWIYLAFILDRLLMWLYMFAFVVGSLSFVV--LVATENYPENIVAAENDMKDL----- ------------------------------------- >CionaSavignyi_reftig125/1-485 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ LHTGFILLVLAASAASVLSEFQS---------SES-RLMKRLL-----NGYNNQFRPYNVEYEN-KTLVSMG MTLSQIISVKEKSQELTTSVYMTFDWVDNRFSWDP----EEYEGITI-IRIP--PY---AIWSPRIVLQN-- -SID-GNF-DVSVPVMALIKYTGEVQWIPPGLYKSTCTIVVALFPFDWQNCTMVFRSATYDRSEMEFGL--- ----------------------SYGDSIYVDPEAFKENGEWKIVQRPVRINSDS------SDP------TYQ D----VTFYLIIRRKPQFYVINLIIPCILMSSLSCFVFYLPSVSC--EKMTLSISVLLGETVFLFLIAQRVP ETSLAVPLIAGYLLFVMILVIISVISSVVVCNVHYRSNTT-HS-MPDWVVWFFMEKLAPILR---VER--P- ------------------------------------------------------------------------ ---SEEESGACSARPRRCSSV--------------------------------------SARKAMRQRKEWK -------------------------SPSEIMFDHQASRLGFRR----------------------------- ---------------------------------------------------------RHVVNHYGMTEVNVA S-----------------------------------------------------PENDFEPAAE-SINYIAN QLKEENDSA-QSKDDWGYVALILDRILLWIYFAAFSLGTLFFFL--QSTFAYYPEQ---------------- ------------------------------------- >CionaIntestinalis_7_4/1-499 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M INCLLIFLLLPITKTSAAKFES----------TEG-RLANYLL-----NGYNPQFRPYNKKYEN-KTFVDVM MTLSQIISVKEKSQEFTTSVYMQYDWLDDRFGWVP----DDYDGITT-VRIP--CA---SIWVPRIVLQN-- -SID-GNF-DVSLRTNALIQHDGKVSWLPPALYKSTCTIEVALFPFDWQNCTMVFRSATYDRTEMEFGI--- -----------------------PIDTVYIDLSAFQSNGEWDILQRPVKINSNE-----NDKT-------YQ D----ITFYFIIRRKPQFYIINLIIPCILMSSLSCFVFYLPSISC--EKMTLSISILLGETVFLFLIAQRMP ETSLAVPLIAGYLLFVMILVIISVICSVVVCNVHYRSNTT-HS-MPDWIVWIFMEKLAPLLK---VER--P- ------------------------------------------------------------------------ ---SEEESGACSARPRRCSSV-----------------------------------------STRKAMKQRS ----------------------EWKPPSEILFDHQASRLGFRARHYLNE----------------------- ---------------------------------------------------------YGMTGINVAAPENGS F-------------VPPSFKK---------------------------------LPKGFQPAAD-SIDYIAN QKKEENEMG-QSQDDWGYVALILDRLLLWVYLATFTLGTLFFFL--QTKFAYYPEKLN-------------- ------------------------------------- >AmericanAlligator_scaffoldNW017708085/1-508 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------MDRLPHGVGWLVSQR DVGAGTDVHSPPPRAPPGTGASP---------HEG-QLLETLF-----TNYSPTVRP-ARCPLD-RVPVSVG LVLSQLINLDEKNEELTTKVYLDLQWTDYRLSWDP----ATYEGLST-LRVT--PD---RVWLPDIFLVN-- -TND-GNF-EIALPVTVLVSYDGSMRWLPPAVYHSSCSIEVTYFPFDWQNCSMVFRSYTYDASELSLQH--- ----------------PQDPQGRELREVVISESTFIENGQWSIEHRAARRTRLP------EDP------HYE D----ITFYLVIRRHPLFYLVNVIIPCVLITVLAIGVFYLPP-DA-GEKMTLSIFALLTLTVFLLLLADKVP ETSLAVPVIVRYLTVAMALVTASVVLSVVVLNLHHRAPGT-HH-LPRWIRWLFIHQLPRYLW---LQR--P- ------------------------------------------------------------------------ ---KPEPPLAPQPSPAPAPRP-----------------------------------------LPARTPDHYF ----------------------LRVPGPAALLPQPNRLAPEPW----------------------------- ---------------------------------------------------------GQNLRRLVAGPPRAL A-----------------------------------------------------LPPELREAVA-AVAYVAE QLREQDIYD-TLQDDWHYVAMVVDRLFLVAFLLGTTLGTAAIFL--GASQNRPPPEPFP------------- ------------------------------------- >SpottedGar_LG2_3/1-468 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------ASQ---------TER-RLLEKLF-----KNYNLKVRP-AQTVQE-RVQVRVG MTLSQLIGLNEKNEEMTTNVFMNMAWNDYRLSWDP----EEHDNILV-LRIP--SV---KVWRPDIYLIN-- -NND-GQF-DVALNVNVLVYSNGTVNWLPPAIYRSSCSIKVTYFPFDWQNCTMVFRSYTYDASEVDLQY--- ----------------ALNESGQEIKEIIIDENAFTENGEWQICHKPSRKNTGEGL--------------YE D----ITFYLIIERKPLFYIINIIVPCILTSILAIFVFYLPP-DA-GEKMTLSISVLLALTVFLLLLADKVP ETSLGIPIIVNYLMFTMILVTFSVILSVVVLNLHHRSSST-HD-MPLWVRKVFIHILPRYLG---IQR--P- ------------------------------------------------------------------------ ---RPEEPLEETTKNDAPSHS-----------------------------------------MDGRPTDQYF ----------------------IRKINPELIIPWNSRSDS-------------------------------- ---------------------------------------------------------PVRLQKYLDGQNYCL I-----------------------------------------------------LPPDLKSAVA-AVTYMAD QLKSQEEHD-TITADWQYIAMVVDRLFLWLFVVFTSLGTLTIFL--DASFNYTPEEPFS------------- ------------------------------------- >Zebrafish_7_2_chrnb1.2/1-486 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----MVWLNINYDINGSRKASE---------AER-RLLEDLF-----QDYNLKVRP-ARTWNE-RVMVRVG MTLVQLISLNQKNGEMTTNVFMNMEWTDYRLSWNP----EDYDKIDV-VRIP--PV---KVWRPDIYLIN-- -NND-GQF-DVALYVNVLVRSDGTVSWLPPAIYRSSCSIEVAYFPFDWQNCSMVFRSYTYDSSEVDLQY--- ----------------GLDEDGNELHEIVIDENAFTENGEWQICHKPSRKNVQDDL--------------YE D----ITFYLIIERKPLFYVINIIVPCILTSVLAIFVFYLPP-GA-GEKMTLSISVLIALTVFMLLLADKVP ETSLAIPIIVNYVMFTMILVTFSVILSVVVLNLHHRTPST-HH-MPGWVRKVFINLLPRYLG---VLR--P- ------------------------------------------------------------------------ -TPEEPVEEEPKENVPMGCLG-----------------------------------------NSLRPGGEYF ----------------------IRKINPELVMPWRGSHNES------------------------------- ---------------------------------------------------------TVKLQRFSNSDNYCL I-----------------------------------------------------LPPNLKSAIA-AITYMSE QLKKQDVDD-TMTDDWQYIAVVLDRLFLWLFVVITTLGTLTMFL--DASFNYTPDQPFP------------- ------------------------------------- >Medaka_18_1/1-503 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------MTDIMGQMKMKF SVRTSFIVFVCISFCLAFTGASE---------TER-NLHQKLF-----QNYNLKVRP-ARYWEE-KVMVRVG MTLSQLVSLNEKNGEMTTNVYMNMQWSDYRLSWKP----EEYDNIDV-LRIP--AN---KVWRPDIYLIN-- -NND-GHF-DVALYVNVLVYSDGTINWLPPAIYRSACSIDVAYFPFDWQNCSMVFRSYTYDASEVDLQY--- ----------------FLDDDGKEIHEIVIDENAFTENGEWAICHKPTRKNVKDGL--------------YE D----ITFYLIIERKPLFYIINIILPCILTSVLAIFVFYLPP-GA-GEKMTLSISVLIALTVFMLLLADKVP ETSLSTPIIVNYVMFTMILVTFSVILSVVVLNLHHRTPST-HI-MPNWVRKVFIHILPKYIG---MMR--P- ------------------------------------------------------------------------ KIEDPLLEEESSEDSSTTLGF-----------------------------------------GGRHPGGEYF ----------------------FRKINPDLVLPWRGRCES-------------------------------- ---------------------------------------------------------AVHLQRLPNTDSYCL V-----------------------------------------------------LPPNLKSAIA-AVTYMAE QLRKQDIDD-TMTGDWQFIALVVDRLFLWLFVVITTLGTLAMFL--DASFNYTPDNPFP------------- ------------------------------------- >Fugu_scaffoldNW004072381_2/1-478 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------MYNFIDTSVVGASE---------IER-RLHQKIF-----HNYNMKVRP-ARYWEE-KVMVRVG MTLSQLVSLNEKNEEMTTNVFMNLAWSDYRLSWKP----EEYDNITV-LRIP--PN---KVWRPDIYLIN-- -NND-GQF-DVALYVNVLVYNDGTVNWLPPAIYRSSCSIQVSYFPFDWQNCSMVFRSYTYDASEVDLQY--- ----------------FLDDDGKEVHEIVIDENAFTENGEWAICHKPSRKNIKEDL--------------YE D----ITFYLIIQRKPLFYIINIIVPCILTSVLAIFVFYLPP-GA-GEKMTLSISVLIALTVFMLLLADKVP ETSLGIPIIVNYVMFTMILVTFSVILSVVVLNLHHRTPST-HI-MPNWVRKVFIHFLPKYIG---MTR--P- ------------------------------------------------------------------------ ----KLEEHDDTSEEEPIRSF-----------------------------------------NGRQPGGEYF ----------------------IRKINPDLVMPWRSRCES-------------------------------- ---------------------------------------------------------TVQLQRLAHSDSFCL I-----------------------------------------------------LPPNLKSAIE-AVTYMAE QLKKQDTDD-SMTGDWQFIALVVDRLFLWLFVIITTLGTLVIFL--DASFNYTPDDPFP------------- ------------------------------------- >Stickleback_VII_2/1-470 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------ASE---------TER-RLHQKLF-----ENYNMKVRP-AAYWEE-KVMVRVG MTLSQLVSLNEKNEEMTTNVFMNLAWTDYRLSWNP----EDFDNIQV-LRIP--AI---KVWRPDIYLIN-- -NND-GQF-DVALYVNVLVYSDGTVNWLPPAIYRSSCSIEVSYFPFDWQNCSMIFRSYTYDASEVELQY--- ----------------FLDDEGKEIQEIVIDENAFTENGEWAICHKPSRKNIKEDL--------------YE D----ITFYLIIQRKPLFYIINIILPCVLTSVLAIFVFYLPP-GA-GEKMTLSISVLIALTVFMLLLADRVP ETSLGIPIIVNYVLFTMILVTFSVILSVVVLNLHHRTPST-HI-MPTWVRKVFIHFLPKYIG---MTRPNP- ------------------------------------------------------------------------ ---EEPLLEEESSEDSPIRGL-----------------------------------------NGRQPGGEYF ----------------------FRKINPDLVAPWRGRCES-------------------------------- ---------------------------------------------------------TVQLQRLPDTNSYCL I-----------------------------------------------------LPPNLKSAIS-AVTYMAE QLKKQDMDD-TITGDWQFIALVVDRLFLWLFVIITTLGTLAMFL--DASFNYTPDEPFP------------- ------------------------------------- >SpottedGar_LG2_2/1-492 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MKGLGIVLLMCSICAVADASE---------AEK-NLIAKLF-----TNYTLKVLP-VKNVGE-RLVVRVG MKLASLIDLNEKEEEMSTNVYMDLTWSDYRLSWNP----AEHDNIQV-LRLP--AG---KVWLPDIVLIN-- -NND-GVF-DVSLRVHVQAYSDGRVTWSPPALYKSSCGIKVTFFPFDWQNCTMVFRSYTYDASEIDLQY--- ----------------ALDKEGKEIHEIIMD-ESFSENGEWQIRYKPSRKNVGPDL--------------YE D----ITFYLIIERKPLIYVLNIVIPCILITIIAIFNFYLPP-DA-GEKMGLSINVLLTLTVFLLLLADKVP ETSLGVPIIVNYLMFTMILVTFSVILSVVVLNLHHRSPNT-HV-MPLWVRKIFIHLLPQYLG---LLR--P- ------------------------------------------------------------------------ ---KTETPLSLELSPKREVPV-----------------------------------------SVSRAADEYF ----------------------IRKPTSNFLFPKPNRFQPESL----------------------------- ---------------------------------------------------------TVDLRKFINGPSHYL T-----------------------------------------------------LPPDLKSAID-AVTYIAE TLQAEKDYE-ALKEDWQYVAMVVDRLFLWIFVIFTTVGTLAIFM--DASFNDTPQDPFMNPYP--------- ------------------------------------- >Zebrafish_7_1_chrnb1/1-492 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M KAQDWIIVTCCLCGLGAMTGATE---------MED-KLMKKLF-----SAYNSKVRP-ARNPEE-RVVVRIG MILSSFVSLNMKDEEMNTIVMMNLEWNDYRLSWNP----KDYGGVDV-LRIS--SG---KVWLPDIVLIN-- -NND-GVF-GVALQVHVQAYSNGRVTWTPPALYKSSCGVKVTYFPFDWQNCTMVFRSYTYDSSEVDLQH--- ----------------ALDKRGKEIKEIILD-TGFSESGEWHIRHKVSRKNVREDL--------------YE D----ITFYLIIERKPMFYVVNIVLPCILITIIAIFNFYLPP-DA-GEKMGLSINVLLTLTVFLLLLANKIP ETSLGVPIIVNYLMITMILVTFSVILSVVVLNLHHRSPNT-HQ-MPLWVRKIFIHMLPPYLG---MLR--P- ------------------------------------------------------------------------ ---KVETPLFLEKPAKKENIQ-----------------------------------------AISRVADEYF ---------------------IRKPSNMNFLFPKPHRYQPDGQ----------------------------- ---------------------------------------------------------CTDLRKFIDGPSHYL T-----------------------------------------------------LPPELKTAVE-AITYIAE QLQAEKDYE-ALKEDWQYVAMVADRLFLWIFVIFTTLGTLGIFT--DASFNATPTDPFP------------- ------------------------------------- >Medaka_18_2/1-498 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M KNLDVFLLACCLHGLSTLGGAAQ---------VEQ-ALMKSLF-----SDYNLKVRP-AHVPES-RVVVRVG MILSSFVGLNMKNEEMSTTVVMNLEWTDYRLTWNP----KQHDGIKM-LRVP--SG---KVWLPDIVLIN-- -NND-GVF-DVALRVHVLVYSDGRITWTPPALYLSSCGVKVTYFPFDWQNCTMQFRSYTYDSTEIDLQY--- ----------------ALDSKGKEIREIQLD-EGFSESGEWHIRHKPSRKIMKDDL--------------YE E----MTFYLIIERKPLYYIINIIIPCILITIIAIFNFYLPP-DA-GEKMGLSINVLLTLTVFLLLLADKIP ETSLGVPIIVKYIMFTMILVTCSVILSVVVLNLHHRSPNT-HM-MPMWIRKIFLHMLPPYLF---MRR--P- ------------------------------------------------------------------------ --KQENLQYLESVPRREMKVM-----------------------------------------AISKAADEYF ----------------------IRKPDSSILFPKPNRFHSDGM----------------------------- ---------------------------------------------------------YTDLRKFIDGPSTYL A-----------------------------------------------------LPDELKTAID-AITYIAE ALQAEKDYE-ALKEDWQFVAMVVDRMFLWIFVVFTTLGTLAIFI--DASFNHTPKDPFKSPWGSF------- ------------------------------------- >Fugu_scaffoldNW004072381_1/1-501 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M KYLLLLPLSCCLCSLIPLGGASE---------VEK-TLMKTLF-----SNYTLKVRP-AISPEQ-RVVVRVG MILSSFVGLNMKNEEMSTIVVMNLEWTDYRLSWSP----KQYGGIEV-LRIP--SG---KVWLPDIVLIN-- -NND-GVF-HVALHVHVQVYSNGRVTWTPPALYCSSCGVKVEYFPFDWQNCSMQFRSYTYDSTEIDVQY--- ----------------ALNLRGQEIREIQLD-EAFTEGGEWYIKHRPSRKVMLD-------DE-------YE G----MVFYLIIERKPLYYVLNIILPCILITIIAIFNFYLPP-DA-GEKMGLSINVLLTLTVFLLLLADKIP ETSLGVPIIVNYIMLTMILVTFSVILSVVVLNLHHRSPNT-HQ-MPMWVRKIFIHLLPPYLC---MMR--P- ------------------------------------------------------------------------ --KVEAPLYLEALPRREKKVT-----------------------------------------TVSKVADEYF ----------------------IRKPDMSVLFPKPNRFHSEGL----------------------------- ---------------------------------------------------------CTDLRKFIDGPSSYL S-----------------------------------------------------LPEELKSAIE-AITYIAE ALQAEKDYE-ALKKDWQYVAMVVDRMFLWIFVIFTTVGTLAIFA--EASFNRAPANPFPTTAKDVWFS---- ------------------------------------- >Stickleback_VII_1/1-470 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------ASD---------MEK-TLLKKLF-----TDYNLKVRP-ASSPEE-RVVVRVG MVLSSFVGLNMKNEEMSTIVVMNLEWTDHRLSWKR----EEYDGIEV-MRIP--AG---KVWLPDIVLIN-- -NND-GVF-DVALHVHVQAYSNGRVTWTPPALYCSSCGVKVTYFPFDWQNCTMQFQSYTYDSTEIDVQY--- ----------------ALDSKRNEIREIQLD-EAYTEGGEWTIKHKPCRKNMND-----DQ---------YE V----MTFYLIIERKPLYYVLNIILPCILITIIAIFNFYLPP-DA-GEKMGLSINVLLTLTVFLLLLADKIP ETSLGVPIIVNYIMFTMILVTFSVILSVVVLNLHHRSPST-HM-MPMWVRKIFIHLLPPYLY---MLR--P- ------------------------------------------------------------------------ ---KVETPLSLEFMPRREKKV-----------------------------------------FTISKADEYF ----------------------IRKPDSSILFPKPNRFHPEGM----------------------------- ---------------------------------------------------------CTDLRKYIDGPSSYL T-----------------------------------------------------LPDELKSAIE-AITFIAE ALQAEKDFE-ALREDWQYVAMVVDRMFLWIFVIFTTVGTLAIFA--DASFHRTPTDPFK------------- ------------------------------------- >Coelacanth_scaffoldJH127792/1-484 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MRSCEILVFGVLLISLSGVGSSD---------TGS-KLLDDLF-----RDYNLHVRP-ARATGD-KVVVRVG LMLSELLSL---------------SWKDYRLSWNP----ADYENFKS-LRIS--SK---KVWLPDIVLLN-- -NND-GNF-HVTLTVNVVVNNDGTVEWEPPAMYRSSCSIEVTYFPFDWQNCSMVFRSYTYDSSEIQLQY--- ----------------MRDKEGREIQEIVIEEASFSENGQWEIRHKPGRKNKLS-----DDEN-------YE D----ITFFLIIQRKPLFYLINIIIPCILITILSIFVFYLPP-DA-GEKITLAIFVLLTLTIFLLLLADKVP ETSLGAPIIVNYLMFTMILVTFSVILTVVVLNLHHRSSNT-HV-MPLWVRQIFIHMLPKYLR---LQR--P- ------------------------------------------------------------------------ -KTEPPLKALFQHKPKENTIR-----------------------------------------LNNRVMDEYF ----------------------IRQPNRDFIFPKNNRFHLDQL----------------------------- ---------------------------------------------------------TTDLRRFMDGPSHYL T-----------------------------------------------------LPSDLKSAID-SVCYIAE QLQKENDYE-NLKEDWQYVAMVVDRLFLWIFITVTSLGTLTIFL--DASFNHPPEDPFKNPHF--------- ------------------------------------- >Opossum_2_2/1-501 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M IPRVLLLGTLGILFSMNGARGTL---------AEG-QLLEKLF-----SGYDNSVRP-ARDLGD-RVPVSIG LTLTQIISLNEKDEELITKVYVDLAWTDYRLSWNP----AEHEGIDS-LRIA--SD---SVWLPDVVLMN-- -NND-GNF-DVSLNIHVLVTSDGSVHWLPPAVYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSTQVSLSP--- ----------------GLGLDGQQRNEIYIHGGNYIENGQWEIIHKSSRLNGPSGGQGGKEGE-------RH D----VTFYLIIRRKPLFYLVNVIIPCVLITLLAIFVFYLPP-DA-GEKMTLSIFALLTLTVFLLLLASKIP ETSLAVPIIVKYLMFTMILVTFSVILSVVVLNLHHRSPHT-HQ-MPLWICQIFIHKLPWYLG---MKR--P- ------------------------------------------------------------------------ KVERTLRPDPPVLALKDFPSS-----------------------------------------GWGRATDEYF ------------------------IRKPPGDFSKTNRYQPELSP---------------------------- ---------------------------------------------------------PDLRRFINGDPSGSR R-----------------------------------------------------LPPELREVVT-SISYIAR QLQEQEDYE-DLKEDWQYVAMVVDRLFLWTFIIFTSVGTLFIFL--DASYHLPPSEPFP------------- ------------------------------------- >Mouse_11_1/1-501 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------MA LGALLLLLGVLGTPLAPGARGSE---------AEG-QLIKKLF-----SNYDSSVRP-AREVGD-RVGVSIG LTLAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDP----AEHDGIDS-LRIT--AE---SVWLPDVVLLN-- -NND-GNF-DVALDINVVVSFEGSVRWQPPGLYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLKT--- ----------------GLDPEGEERQEVYIHEGTFIENGQWEIIHKPSRLIQLPGDQRGGKEG------HHE E----VIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPP-DA-GEKMGLSIFALLTLTVFLLLLADKVP ETSLAVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHT-HQ-MPFWVRQIFIHKLPPYLG---LKR--P- ------------------------------------------------------------------------ ---KPERDQLPEPHHSLSPRS-----------------------------------------GWGRGTDEYF ----------------------IRKPPSDFLFPKLNRFQPESS----------------------------- ---------------------------------------------------------APDLRRFIDGPTRAV G-----------------------------------------------------LPQELREVIS-SISYMAR QLQEQEDHD-ALKEDWQFVAMVVDRLFLWTFIVFTSVGTLVIFL--DATYHLPPPEPFP------------- ------------------------------------- >Human_17_2_CHRNB1/1-501 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------MT PGALLMLLGALGAPLAPGVRGSE---------AEG-RLREKLF-----SGYDSSVRP-AREVGD-RVRVSVG LILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDP----AEHDGIDS-LRIT--AE---SVWLPDVVLLN-- -NND-GNF-DVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQT--- ----------------GLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREG------QRQ E----VIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPP-DA-GEKMGLSIFALLTLTVFLLLLADKVP ETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHT-HQ-MPLWVRQIFIHKLPLYLR---LKR--P- ------------------------------------------------------------------------ ---KPERDLMPEPPHCSSPGS-----------------------------------------GWGRGTDEYF ----------------------IRKPPSDFLFPKPNRFQPELS----------------------------- ---------------------------------------------------------APDLRRFIDGPNRAV A-----------------------------------------------------LLPELREVVS-SISYIAR QLQEQEDHD-ALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFL--DATYHLPPPDPFP------------- ------------------------------------- >ChineseSoftshellTurtle_scaffoldJH205571/1-493 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MARRAPVLVTLWLIPTVVVGSLQ---------TEE-RLLEKLF-----ENYNSNVRP-ARTLTD-KVFIRVG MSLSQLISLNEKNEELTTKVYMDLEWTDYRLSWNL----SDFDYISS-IRLS--SD---KVWLPDIYLMN-- -NND-GNV-DIALPVNVLVSHVGTVQWLPPALYRSSCSIQVTYFPFDWQNCSMVFQSYAYGATELGLLH--- ----------------PLDEAGREVQEIIIFENTFIDNGQWEIRHKPARRNTLP------GEL------QHE D----ITFYLIIRRRPLFYIINVIIPCILITILAIFVFYLPP-DA-GEKMTLSIFALLTLTVFLLLLADKVP ETSLAVPIIVKYLMFTMILVTFSVILSVVVLNLHHRSPNT-HD-MPFWVRQIFIHQLPRYLG---LQR--P- ------------------------------------------------------------------------ ---KPEPILKPPPASKRELVV-----------------------------------------KSNRSTDEYF ----------------------IRKPTCDFLFPKPSRFYQDPF----------------------------- ---------------------------------------------------------LQDLRRFIDGPSECL V-----------------------------------------------------LPLDLKSAMD-AVTYIAQ QLQDQEDYD-TLKEDWQYVAMVVDRLFLWTFITFTSVGTLTIFL--DASCNLPPLHPFP------------- ------------------------------------- >BurmesePython_scaffoldNW006540393/1-405 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------EWIDYRLTWDP----AEFEGITS-IRLY--AE---EVWLPEVVLMN-- -NND-GVF-GIALSGNVLVRHDGRVRWQPPALYRTSCSIQVTYFPFDWQNCTMVFRSYTYDASEITLLH--- ----------------PVDEDGQEVKEIHIYENTFIDNGQWEILHKPARKNTHP------EDP------LYE D----ITFYLIIRRKPLFYLINVIIPCILITILAIFVFYLPP-DA-GEKMTLSIFALLTLTVFLLLLAKKVP ETSLAVPIIIKYLTFTMILVTFSVIFSVVVLNIHHRSPSS-YK-MPFWVRQIFIHKLPRYLC---LRR--P- ------------------------------------------------------------------------ ----------KPEPPLRETLV-----------------------------------------KSSRHADEYF ----------------------IRTPACDRSKPGRFQLETL------------------------------- ---------------------------------------------------------STDLRKFIDGPSHGI A-----------------------------------------------------LPPDLKSAVD-AVSYIAE QLQEQEDYD-ALKEDWEYVAFVVDRLFFWTFIVFTTTGTLTIFL--DASFHLPPEQPFL------------- ------------------------------------- >AustralianGhostshark_scaffoldNW006890054/1-523 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MRKLAISILLIAGLSRTECSSQN---------QEE-KLINDLF---NVKNYNKEIRP-VQHKKE-VVNVSLS LTLSNLISLKEVDETLLTNVWIEHGWFDTRLSWKT----LDYGGVSI-LRLP--PS---MVWLPDIVLEN-- -NVD-GQY-EVAYYCNVLVSSDGFIYWLPPAIFRSSCPINVVHFPFDWQNCSLKFTSFNYNANEIHLEL--- -------------KTEMKDGKTYPIEWIIIDPEAFTENGEWEIVHHPAKKNIHV---NVSPNS-----TKYQ D----ITFYLIIKRKPLFYLINIITPSVLISFLMLLAYYLPA-DS-GEKMTLSINVLLAQSVFLLLMSQRLP ETADAVPLITKYLIFIMVLVTFVIVNCVVVLNIHFRTPST-HV-LSAWTKRLFLETLPRILH---MSQ--P- ------------------------------------------------------------------------ ---EEEELWVNGAIQRRSSSV-----------------------------------------GYIAKAEEYF ----------------------TIKSRSELMFEKQSQRHGMKARTTPK------------------------ ---------------------------------------------------------APTASSGEKQHEISD Q-----------------------------------------------------FYSEIKPGID-AANYIVK HTKDTNDYD-EEKDSWNRVARTVDRLCLFLITPIIIIGTISIFL--MGKLNHPPALPFENDGFDYAPGHPRY LIK---------------------------------- >Opossum_2_4/1-320 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MEGWTLGLLLALAISGAGALN----------EEE-RLIRYLF---QEKAYNKKLRP-VDRQGD-RVDIFLA LTLSNLISLKEVDETLTTSVWIEHGWTDSRLQWDE----AHFGNINV-LRLP--SD---MLWLPEIVLEN-- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------FLLFGMVLVTVIVLICVVTLNIHHRTPST-HI-LSQGVRKMFLETLPRLLH---MSQ--P- ------------------------------------------------------------------------ -----EAEPVLGSQLRRSSSL-----------------------------------------GYISKAEEYF ----------------------TVKSRSDLMFEKQSERHGLASRV--------------------------- ---------------------------------------------------------TPARRPPPGSEESQQ E-----------------------------------------------------LFNEIKPAVD-GANFIVT HMRDQNNYN-EEKDSWSRVARTVDRLCLFVVTPLMTLGTAWILL--QGMYNQPPLQPFPGDPFTYAEKDRRF V------------------------------------ >Mouse_1_1/1-520 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------MAG PVLTLGLLAALVVCALPGSWGLN---------EEQ-RLIQHLF---NEKGYDKDLRP-VARKED-KVDVALS LTLSNLISLKEVEETLTTNVWIDHAWVDSRLQWDA----NDFGNITV-LRLP--PD---MVWLPEIVLEN-- -NND-GSF-QISYACNVLVYDSGYVTWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSL--- -------------KQEEENNRSYPIEWIIIDPEGFTENGEWEIVHRAAKLNVDP---SVPMDS-----TNHQ D----VTFYLIIRRKPLFYIINILVPCVLISFMINLVFYLPG-DC-GEKTSVAISVLLAQSVFLLLISKRLP ATSMAIPLVGKFLLFGMVLVTMVVVICVIVLNIHFRTPST-HV-LSEGVKKFFLETLPKLLH---MSR--P- ------------------------------------------------------------------------ ----AEEDPGPRALIRRSSSL-----------------------------------------GYICKAEEYF ----------------------SLKSRSDLMFEKQSERHGLARRL--------------------------- ---------------------------------------------------------TTARRPPASSEQVQQ E-----------------------------------------------------LFNEMKPAVD-GANFIVN HMRDQNSYN-EEKDNWNQVARTVDRLCLFVVTPVMVVGTAWIFL--QGVYNQPPLQPFPGDPFSYSEQDKRF I------------------------------------ >Human_2_2_CHRND/1-517 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MEGPVLTLGLLAALAVCGSWGLN---------EEE-RLIRHLF---QEKGYNKELRP-VAHKEE-SVDVALA LTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNA----EEFGNISV-LRLP--PD---MVWLPEIVLEN-- -NND-GSF-QISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLKYTAKEITLSL--- -------------KQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDP---RAPLDS-----PSRQ D----ITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPA-DS-GEKTSVAISVLLAQSVFLLLISKRLP ATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNIHFRTPST-HV-LSEGVKKLFLETLPELLH---MSR--P- ------------------------------------------------------------------------ ----AEDGPSPGALVRRSSSL-----------------------------------------GYISKAEEYF ----------------------LLKSRSDLMFEKQSERHGLARRL--------------------------- ---------------------------------------------------------TTARRPPASSEQAQQ E-----------------------------------------------------LFNELKPAVD-GANFIVN HMRDQNNYN-EEKDSWNRVARTVDRLCLFVVTPVMVVGTAWIFL--QGVYNQPPPQPFPGDPYSYNVQDKRF I------------------------------------ >Coelacanth_scaffoldJH126941_1/1-525 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MQEIYIFLTLLLSPWLSGCLCRN---------QEE-RLIHHLF---VERDYRKELRP-VSSQEE-TVKLQLG MTLSNLISLKETDETLTANIWIEHSWNDSRLAWNM----SEFSNIRV-LRLP--SS---MVWQPEIVVEN-- -NND-GNF-EITYYCNVLVFSSGNIYWLPPAIYRTSCPINVEYFPFDWQNCTFKLRSLAYNAKEVTFQL--- -----------KEVIDTVTNKSYTIEWMIIDPEAFTENGEWEIIHKAGKKNIDK---SHSPDS-----IRYQ D----ITFYLIIKRKPLFYIINIITPCILISFMVSLVYYLPA-DS-GEKMTLSISVLLAQSVFLLLISQRLP ATSHAVPLIGKYIMFVVVLVTIVVVNCVIVLNLHFRNPST-HT-MSEWTKEFFLKKLPRLLH---MSR--P- ------------------------------------------------------------------------ --AEADHIPCNGILQRRSSSV-----------------------------------------GYIVKAEEYF ----------------------TVKSRSELMFEKQSERHGLATRV--------------------------- ---------------------------------------------------------TPAARYGTGGDDDGD DANDQ-------------------------------------------------LFNEMKPAID-GANFIVK HLRDKNDYN-EEKDNWYRIARTVDRLCLFLVTPVMTLGTFYIFL--MGAYNHPPAVPFPGDPFDYKEEHARL I------------------------------------ >WesternClawedFrog_scaffoldNC030681/1-521 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MAGIWICLLLPIFSYFQGCLSES---------EEE-RLLNHIF---GERGYRKELRP-VEHTGE-TVNVSLA LTLSNLISLKEADETLTTNVWVELGWYDKRLAWDM----EEFHHINI-IRVP--PD---MVWQPQLILEN-- -NNN-GVF-EVAYYSNVLVNSDGFMYWLPPAIFQTSCSINVNYFPFDWQNCSLKFSSLTYNAKEINLQL--- -----------RQDQDEESQRNYPVEWIIIDPEGFTENGEWEIVHIPAKKNIDR---SLTPES-----TKYQ D----ITFYLIIKRKPLFYIINILAPCVLIALMANLVFYLPA-DS-GEKMTLAISVLLAQSVFLLLISQRLP ETSFAIPLISKYLMFIMVLVTIVVVSCVIVLNLHFRTPST-HV-ITERMKEIFLNKLPRILH---MSR--P- ------------------------------------------------------------------------ --AEPEPEPWSGVLLRRSSSV-----------------------------------------GYIVKAEEYY ----------------------SVKSRSELMFEKQSERHGLTSRA--------------------------- ---------------------------------------------------------TPARVNPLNSNNSQD Q-----------------------------------------------------LYGEIKPAID-GANFIVK HMRDKNDYN-EEKDNWYRIARTVDRLCLFLVTPVMIIGTLWIFL--GGAYNLPPSLPFPGDPFDYNKEHKRL I------------------------------------ >AnoleLizard_scaffoldGL343304_2/1-530 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MDRPMLRLTLLWALVLPGAIGVN---------MEE-KLINYLF---TEKNYNKNLRP-VISKEE-SVTIKLA LTLSNLVSLKEAEETLTSNVWIEHGWTDYRLQWNE----SEFGGIGV-LRLS--PD---MLWLPHIVLEN-- -NND-GNF-EITYSCNILVYSNGLVYWLPPAIFRSACPINVDFFPFDWQNCTLKFNSLMYNANEITLEV--- --KDDVELPEQIEGEKEKPAQSFLVEWIIIDPEGFTENGEWEIIHRPARKNIDP---SVPRES-----KKHQ D----ITFYLIIKRKPLFYIINIVTPCILIAFMTILIFYLPA-DS-GEKVTMAISILLAQSVFLLLISQRLP PTSFAIPLIGKYLLFVMLLVTAIGVLCVVELNIHYRTPST-HR-LTDWTKEFFLETLPRLLH---ISR--P- ------------------------------------------------------------------------ --EESEPEPRDGLLIRRSSSV-----------------------------------------GYIVKAEEYF ----------------------TVKSRSELMFEKQSERHGLASRI--------------------------- ---------------------------------------------------------TPARPNPHGTDGMEE Q-----------------------------------------------------LYNEIKPAIA-GANFIVK HMRDKNDCS-EEKESWNRIAQTLDYVCFLLVTPVLTLGTLWIFM--MGYYNHPPPLPFEGDPFDYREEHKRY I------------------------------------ >Chicken_9_1/1-513 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---MAVLLALFGALVLSGGLCVN---------QEE-RLIHHLF---EERGYNKEVRP-VASADE-VVDVYLA LTLSNLISLKEVDETLTTNVWVEQSWTDYRLQWNT----SEFGGVDV-LRLL--PE---MLWLPEIVLEN-- -NND-GLF-EVAYYCNVLVYNTGYVYWLPPAIFRSACPINVNFFPFDWQNCTLKFSSLAYNAQEINMHL--- -----------KEESDPETEKNYRVEWIIIDPEGFTENGEWEIIHRPARKNIHPSYPTESSE--------HQ D----ITFYLIIKRKPLFYVINIVTPCVLIAFMAILVFYLPA-DS-GEKMTLVISVLLAQSVFLLLVSQRLP ATSHAIPLIGKYLLFIMLLVTAVVVICVVVLNFHFRTPST-HV-MSDWVKEVFLEILPRLLH---MSH--P- ------------------------------------------------------------------------ -----AESPAGAPCIRRCSSA-----------------------------------------GYIAKAEEYY ----------------------SVKSRSELMFEKQSERHGLAS----------------------------- ---------------------------------------------------------RVTPARFAPAATSEE Q-----------------------------------------------------LYDHLKPTLD-EANFIVK HMREKNSYN-EEKDNWNRVARTLDRLCLFLITPMLVVGTLWIFL--MGIYNHPPPLPFSGDPFDYREENKRY I------------------------------------ >SpottedGar_LG14_2/1-523 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------MS SFSFSLHLLLVLVLYTTDTWGRN---------QEE-RLIQHLF---KERAYNKELRP-VQNKDD-VVKVYLA LTLSNLISLKEVDETLLTNVWMEHGWYDDRLSWNA----SDFDNISV-LRLP--PQ---MVWLPEIVLEN-- -NND-GQF-QVAYYSNVLIYPNGYMYWLPPAIFRSSCAINVNFFPFDWQNCSLKFSSLTYNAKEISMHL--- -----------KREADPETNKSYEVEWIIIDPAGFTENGEWEIIHKPARKNIHK---DVPPES-----CKHQ D----ITFYLIIKRKPLFYIINIITPCVLISFMASLVYYLPA-DS-GEKMTLSISVLLAQSVFLLLVSQRLP ETSLAIPLIVKYLMFIMLIVTVVVLNCVIVLNLHFRTPST-HI-MSDWTKEFFLERLPRILR---MSR--P- ------------------------------------------------------------------------ ---AESESHWEGALPRRSSSV-----------------------------------------GYIAKAEEYY ----------------------SVKSRSELMFEKQSERHGLTPRST-------------------------- ---------------------------------------------------------PAAVYKSSNEADVAD Q-----------------------------------------------------LYAEIRPAVD-GANYIVK HMRDKNDYN-EEKDNWSGIARTVDRLCLFIVTPVMTLGTLFIFL--TGTYNHPPPLPFEGDPYNYLEENKRF I------------------------------------ >Zebrafish_24_chrnd/1-518 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MMKTVLLTASLLCFIFQECCGRN---------EEE-RLINYLF---KERGYNKELRP-VQNKDE-TVDIYLA LTLSNLISLKEVDETLLTNVWMEHGWKDHRLTWNE----SEYD-IPV-LRLP--PS---MVWLPEIVLEN-- -NND-AQF-QVAYYCNVLIYSSGDMYWLPPAIFRSSCSINVNYFPFDWQNCSLKFSSLTYNAKEISLNL--- -------------KMEQENTTYYKVEWIIIDPEGFTENGEWEIVHKPARRNIYK---SIPKES-----NKHQ D----ITFYLIIKRKPLFYIVNIIIPCVLISFLASLVYYLPA-DS-GEKMTLSISVLLAQSVFLLLISQRLP ETSMAVPLIVKYLMFIMVLVTVVVLNCVIVLNLHFRTPST-HV-MTEWTKEFFLERLPRLLH---MSL--P- ------------------------------------------------------------------------ ---VEDQPVPESALPRRSSSL-----------------------------------------GYIAQAEEYY ----------------------SVKSRSELMFEKQSERHGLAARPT-------------------------- ---------------------------------------------------------PKATYTSSNDSEVSE Q-----------------------------------------------------LYNEMKPAVE-GANYIVK HMHDKNDYN-EEKDNWSGIARTVDRLCFYVVTPVMMIGTICIFL--MANYNQPPALPFQGDPFSYTEENRRY L------------------------------------ >Medaka_20/1-521 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------MG FQQAGLISAFLLTLLSAECSGRN---------EEE-RLINYLF---LEKKYNKELRP-VEQHGD-TVDVYLA LTLSNLISLKEADETLLTNVWIDHTWIDYRLSWNV----SEFDGIDM-LRLP--SN---MVWLPEIVLEN-- -NND-AQF-EVAYYSNVLVDPSGLCYWLPPAIFRSSCSINVNYFPFDWQNCTLKFTSLTYNAKEIRMLL--- -------------KEDADEENKWTVEWIIIDPESFTENGEWEIIHRPAKRNTYK-HIPMESNK-------HQ D----ITFYLVIKRKPLFYIVNIIIPCVLISFLATFVYYLPA-DS-GEKMTLSISVLLAQSVFLLLISQRLP ETSMSVPLIVKYLMFIMVLVTVVVLNCVVVLNLHFRTPST-HV-MTGWTKRFFLERLPRILH---MSQ--P- ------------------------------------------------------------------------ ---AEPEPQWDGALPRRSSSV-----------------------------------------GYIAAADEYY ----------------------SVKSRSELMFEKQSERHGLTKRPT-------------------------- ---------------------------------------------------------HAAVVKPQEDGGVTD Q-----------------------------------------------------LYAEIKPALD-GANYIIR HRRNKNDYN-EEKDNWSGIARTVDRLCLFLVTPVMTIGTIIIFL--MGICNHPPHLPFKGDPHDYKEDNPRL V------------------------------------ >Fugu_10/1-348 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M EFPALLPVVFLLVLLSAGCWCRN---------EEE-RLIHHLF---KERGYNKELRP-VERHQD-AVDVQLA LTLSNLISLKEVDETLLTNVWIEHTWTDYRLSWNS----TEFDGISI-LRLP--SS---MVWLPEIVLEN-- -NND-AQF-NVAYYCNVLVDSTGFCFWLPPAIFRSSCSISVKYFPFDWQNCTLKFTSLTYNAKEIRLLL--- -------------KEDIVNETKCTVEWIVIDPASFTENGEWEIIHRPAKRNTYK-HIPMESNK-------HQ D----ITFYLVIRRKPLFYVVNIIIPCVLISFLASLVYYLPA-DS-GEKMTLSISVLLAQSVFLLLISQRLP ETSTSVPLIVKYLMFIMVVVTVVVLNCVVVLNLHFRTPST-HV-MSEWT----------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------- >Opossum_2_3/1-500 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MEGTVLCILLLQGLLGLGWGES---------EEL-RLYHHLF-----SNYDAGTRP-VRWPEE-KVSVNLK VTLTNLISLNEKQETLTTSVWIGIEWNDYRLNYSS----KDFGGITT-LRVP--AN---LVWLPDIGLEN-- -NID-GVF-EVAYEANVLVNEGGSVSWLPPAIYRSTCAVEVTYFPFDWQNCSLVFRSQTYSSAEVVFVF--- -----------------SEESGQIVNKIQIDEEAYTENGEWAIDFCSGQIWYHE-D-RSVDAP------GNM E----IIYTLIIRRKPLFYIINIIVPCVLISSLVLLVYFLPA-QAGGQKCTVSISVLLAQTVFLFLVATKIP ETSLSVPLLGRYLIFVMVVAALIVMNCVIVLNVSLRTPNT-HV-MSPRLRHVFLELLPGLLG---SMPS-P- ------------------------------------------------------------------------ ------PAQGAGSSQRRASSL-----------------------------------------GILLRAEELI ----------------------LRKPRSELLFEGQRHRHGPGPGDR-------------------------- ---------------------------------------------------------VIRASSTAALCQSLG T-----------------------------------------------------AASEIRCCVD-SVNFLAE SMREQEDSG-EEVSSWVLVGKALDNICFWAALVLFGFGTGIIFL--GGYLNRVPELPFPPCM---------- ------------------------------------- >Mouse_11_2/1-493 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MAGALLGALLLLTLFGRSQGKN---------EEL-SLYHHLF-----DNYDPECRP-VRRPED-TVTITLK VTLTNLISLNEKEETLTTSVWIGIDWHDYRLNYSK----DDFAGVGI-LRVP--SE---HVWLPEIVLEN-- -NID-GQF-GVAYDSNVLVYEGGYVSWLPPAIYRSTCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFIF--- ----------------AVDDDGNTINKIDIDTAAFTENGEWAIDYCPGMIRRYE--GGSTEGP------GET D----VIYTLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPA-QAGGQKCTVSINVLLAQTVFLFLIAQKIP ETSLSVPLLGRYLIFVMVVATLIVMNCVIVLNVSLRTPTT-HA-TSPRLRQILLELLPRLLG---SSP--P- ------------------------------------------------------------------------ -----PEDPRTASPARRASSV-----------------------------------------GILLRAEELI ----------------------LKKPRSELVFEGQRHRHGTWT----------------------------- ---------------------------------------------------------AALCQNLGA------ ------------------------------------------------------AAPEIRCCVD-AVNFVAE STRDQEATG-EELSDWVRMGKALDNVCFWAALVLFSVGSTLIFL--GGYFNQVPDLPYPPCIQP-------- ------------------------------------- >Human_17_1_CHRNE/1-493 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MARAPLGVLLLLGLLGRGVGKN---------EEL-RLYHHLF-----NNYDPGSRP-VREPED-TVTISLK VTLTNLISLNEKEETLTTSVWIGIDWQDYRLNYSK----DDFGGIET-LRVP--SE---LVWLPEIVLEN-- -NID-GQF-GVAYDANVLVYEGGSVTWLPPAIYRSVCAVEVTYFPFDWQNCSLIFRSQTYNAEEVEFTF--- ----------------AVDNDGKTINKIDIDTEAYTENGEWAIDFCPGVIRRHH--GGATDGP------GET D----VIYSLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPA-QAGGQKCTVSINVLLAQTVFLFLIAQKIP ETSLSVPLLGRFLIFVMVVATLIVMNCVIVLNVSQRTPTT-HA-MSPRLRHVLLELLPRLLG---------- ------------------------------------------------------------------------ -SPPPPEAPRAASPPRRASSV-----------------------------------------GLLLRAEELI ----------------------LKKPRSELVFEGQRHRQGTWT----------------------------- ---------------------------------------------------------AAFCQSLGA------ ------------------------------------------------------AAPEVRCCVD-AVNFVAE STRDQEATG-EEVSDWVRMGNALDNICFWAALVLFSVGSSLIFL--GAYFNRVPDLPYAPCIQP-------- ------------------------------------- >AmericanAlligator_scaffoldNW017712465/1-478 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MEGQGLVLLGATLFCLGGAGGN---------EER-RLFETLF-----SGYDPSTRP-TRRPQD-PVTVELQ LTLTNLISLNEKEETLTTNIWIEIQWVDYRLDYNS----SDFGGIES-LRVP--ST---LVWLPDIVLEN-- -NID-GGF-EVAYYCNVLIYPGGSVYWLPPAIYRSSCPVAVTYFPFDWQNCSLLFKSGTYGGHEVDLRL--- ---------------YTDTVTGAVADSITIDPAAFTENGEWAIRHRPARRVQAG---------------EAP A----VLFLLVIQRKPLFYIINIVIPVVLLSALGLLVYFLPA-QAGGQKCTLSISVLLAQTVFLFLIAQKVP ETSLSIPLLGQYLMFVMVVTMLVVMSCVVVLNVSLRTPST-HRLVGPL--PVLLKLLPRVLG---------- ------------------------------------------------------------------------ --------GEVAERQQDPGPP-----------------------------------------PYLLAAEEEA ----------------------LNTPRSEVLFRHWHLGPS-------------------------------- ---------------------------------------------------------LGGLDPARELCISLA Q-----------------------------------------------------AAPAIRECVA-ACNFVSA TIQAQNDAD-NEAGRWVLVGKALDTLCFWVALLLFAAGTIGIFL--VGQLNQVPDKPFA------------- ------------------------------------- >Opossum_2_5/1-392 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M PWLGRLE--LLLLAGCLGVQGLN---------QEE-KLLNDLM-----RNYNPNLRP-AEVDSD-IINVTLK LTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDP----RDYEDVWV-LRIP--ST---MVWRPDIVLEN-- -NVD-GVF-EVALYCNVLVSPNGCIYWLPPAIFRSSCPVTVTYFPFDWQNCSLVF----------------- ------------------------------------------------------------------------ ---------------------------------------------GGQKCTVSTNVLLAQTVFLFLVAKKVP ETSQAVPLISKYLSFLLVVTILIVVNAVIVLNVSLRSPHT-HS-MAQGVRKVFLHLLPQLLK---MHM---- ------------------------------------------------------------------------ ---RPPAPRRLTRRLQNGSSG-----------------------------------------RPGLNGEGVA ----------------------PWMPCTELVFQQRWER---------------------------------- ---------------------------------------------------------DGLSGHSQEFCASLK Q-----------------------------------------------------AAPAIQACVD-ACKHIAW TRRHQRHYD-NENEEWMLVGRVLDRVCFVAMTALFFCGTFGIFL--MAHHNQVPALPFPGDP---------- ------------------------------------- >Mouse_1_2/1-519 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M QGGQRPQLLLLLLAVCLGAQSRN---------QEE-RLLADLM-----RNYDPHLRP-AERDSD-VVNVSLK LTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDP----KDYEGLWI-LRVP--ST---MVWRPDIVLEN-- -NVD-GVF-EVALYCNVLVSPDGCIYWLPPAIFRSSCSISVTYFPFDWQNCSLVFQSQTYSTSEINLQL--- -----------------SQEDGQAIEWIFIDPEAFTENGEWAIRHRPAKMLLDS-VAPAEEAG-------HQ K----VVFYLLIQRKPLFYVINIIAPCVLISSVAILIYFLPA-KAGGQKCTVATNVLLAQTVFLFLVAKKVP ETSQAVPLISKYLTFLMVVTILIVVNSVVVLNVSLRSPHT-HS-MARGVRKVFLRLLPQLLR---MHV---- ------------------------------------------------------------------------ RPLAPAAVQDARFRLQNGSSS-----------------------------------------GWPIMAREEG ---------------------DLCLPRSELLFRQRQRNGLVQAVLEKLEN---------------------- ---------------------------------------------------------GPEVRQSQEFCGSLK Q-----------------------------------------------------ASPAIQACVD-ACNLMAR ARRQQSHFD-SGNEEWLLVGRVLDRVCFLAMLSLFICGTAGIFL--MAHYNQVPDLPFPGDPRPYLPLPD-- ------------------------------------- >Human_2_3_CHRNG/1-517 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M HGGQGPLLLLLLLAVCLGAQGRN---------QEE-RLLADLM-----QNYDPNLRP-AERDSD-VVNVSLK LTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDP----RDYEGLWV-LRVP--ST---MVWRPDIVLEN-- -NVD-GVF-EVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQL--- -----------------SQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDP-AAPAQEAG-------HQ K----VVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPA-KAGGQKCTVAINVLLAQTVFLFLVAKKVP ETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHT-HS-MARGVRKVFLRLLPQLLR---MHV-RP- ------------------------------------------------------------------------ ---LAPAAVQDTQSRLQNGSS-----------------------------------------GWSITTGEEV ---------------------ALCLPRSELLFQQWQRQGLVAAALEKLE----------------------- ---------------------------------------------------------KGPELGLSQFCGSLK Q-----------------------------------------------------AAPAIQACVE-ACNLIAC ARHQQSHFD-NGNEEWFLVGRVLDRVCFLAMLSLFICGTAGIFL--MAHYNRVPALPFPGDPRPYLPSPD-- ------------------------------------- >Fugu_22/1-561 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------MCVRLALSQSSAGDSLMDS GCPLSLSLFIRVFMISAAASAVN---------LEG-ELFKDLM-----KGYNKNVRP-TEKSGD-ITQVDIK LTLTNLISLNEKEEALTTSVWIELQWCDYRLRWDQPPRSTLYGNITKPLRIP--SK---ILWLPDIILEN-- -NVD-GQF-EVALYCNALVSPDGCVYWLPPAIYRSACPITVNYFPFDWQNCTMVFRSQTYSANEIDMVL--- -----------------KVEDNHTLEWVDIDPEAFTENGEWAIKHRPAKKVINSQYTKDDRE--------YQ E----VIFFLIIQRKPLFYIINIIAPCVLFSSLCLLVYYLPA-KAGGQKCTMSVATLLGQTVFLFLIAKKVP ETSKAVPLIAKYLMFVMSVTTMVVMNCVIVLNVSLRTPST-HI-MTDAVRKVLLNILPRLLK---MRQ---- --------------------------------------------------------MPWTPNNDSTPEIRNR EPLATDGNGIFLVPCRRRSSM-----------------------------------------TLITKAEEYA ----------------------MKTARSELMFSRLKERNGLMKSVLEKLHD--------------------- ---------------------------------------------------------GLDGGTPEQLGISLA K-----------------------------------------------------ASPEVKKCVA-SCKHIAE TARQQSNFQ-NENEEWFLVARVIDRACFIVMASVFFIGTIGVFL--MGHFNQPPSAPFPRDAKTYLPPINVL G------------------------------------ >Stickleback_III/1-525 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----VIHILTIFICIEKTSAIN---------LEG-ELFKDLM-----KGYNKNVRP-MENGSD-VTQVAIK MTLTNLISLNEKEEALTTGVWIGMQWCDYRLRWDRPPRSALYGSITSQLRLP--SK---SIWLPDIILEN-- -NVD-GNF-EVALYCNALVSPNGCVNWLPPAIYRSACAITVNYFPFDWQNCTMVFHSQTYSANEIKLVL--- -----------------TEEDDLTLEWVDIDPEAFTENGEWAIKHRPAKKLINTDYNKDELE--------YQ E----VVFFLIIQRKPLFYVINIIAPCVLFSSLGLLVYFLPA-KAGGQKCTMSIATLLGQTVFLFLIAKKVP ETSRAVPLIGKYLMFVMSVTTMVVMNCVIVLNVSLRTPNT-HK-MTDKVRKILLNILPRLLN---MQM---- ------------------------------------------------------------------------ ---RPWTPDGDNADTRRRSSM-----------------------------------------TLITKAEEYA ----------------------MKTARSELMFAALKERNGLMRSVLEKLKD--------------------- ---------------------------------------------------------ELEGGTAEQLSASLG K-----------------------------------------------------ASSQLQQCVS-SCKHIAK TARQQNNFK-KENEEWFLVAKVIDRVCFIVMVSVFFIGTIGIFL--TGHFNQPPSSPFLGDPKTYLPPTNNL TDRVENGR----------------------------- >Zebrafish_2_chrng/1-540 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------MD QNLSSKIIWLWILLFRFSGALCN---------LEG-SLHRDLM-----VGYNKNIRP-VESHED-IIDVKIK MTLTNLISLNEKEETLTTCVWIEMQWRDYRLRWANRTGFEVYENITR-MRLP--SK---TIWLPDIGLEN-- -NVD-GRF-EVALYANTLIDPDGSVYWLPPAIYRSSCAIKVNYFPFDWQNCSMVFRSQTYNSNEITLML--- -----------------SDEDNVTMEWIEIDPEAFTENGEWMIKHRPAKKVINKRYRPDELE--------HQ E----IIFFLIIQRKPLFYVINIIVPCVLFSSLGLLVYFLPA-KAGGQKCTMTICILLGQTVFLFLIAKKVP ETSQAVPLIGKYLMFVMSVTTITVMNCVVVLNVSLRTPNT-HP-MSNTIRKVLLNILPRVLR---MTMQRWT P------------------------------------------------------------------EQEEG DFKMFALGNGTPLRRRRRSSL-----------------------------------------GLIAKADEYM ----------------------FRTARSELMFSRLKERKGLLKNTLEKIQN--------------------- ---------------------------------------------------------GLGGNTAQDLECSLA A-----------------------------------------------------ASPEVQQCVS-SCKHIAE STKHQNDFQ-SKNEEWFLVARVIDRMCFFVMALLFILGTIGIFL--TGHFNQAPSQPFPGDPKKYLPEISAG DIPG--------------------------------- >SpottedGar_LG14_1/1-468 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------VLSRN---------QEE-ALLKELM-----RGYNKKIRP-VEKEGD-VTQVTLK LTLTNLISL---------------KWCDYRLKWNS----SLYDDFKL-LRVP--SK---SIWLPDIVLEN-- -NVD-GKF-EITLYTNALVYSSGCIYWLPPAIYRSACSIKVTYFPFDWQNCSMVFRSQTYSANEIDLVL--- -----------------TTEDDQTIEWIVIDPEAFTK-----LINDRYLKDDLE----------------YQ E----VVFFLIIQRKPLFYIINMIVPCVLISSLGLLAYYLPA-KAGGQKCTVSISILLAQTVFLILISQKVP ETSQAVPLIGKYLMFAMTVTTIIVMNCVIVLNVSLRTPNT-HI-MTNQVRQIFLNILPRFLR---MHM---- ------------------------------------------------------------------------ -RPWSPERDGAAPTPRRRSSL-----------------------------------------GFIAKADEYV ----------------------LKSARTELMFRHQRDREGLMKAVLEKIRN--------------------- ---------------------------------------------------------GLEGGTAQDIDTSLA Q-----------------------------------------------------ASPEVRLCVE-ACNHIAA SARESNDFQ-SENEEWFLVARVIDRVCFSVMSLLFILGTIGIFL--MGHFNQAPSLPFPGDPRNYLP----- ------------------------------------- >Coelacanth_scaffoldJH126941_2/1-508 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----MGTVVVLLCLSITGVLCRN---------QEE-LLLNKLM-----RDYNSNLRP-AENEGD-IINVTLK LTLTNLISLNEIEEALTTNVWIEMTWRDYRLQWNP----HEHHNITC-LRVP--SK---MVWLPDIVLEN-- -NID-GNF-EITLYINVLVSPNGNIYWLPPAIYRSSCSIIVNYFPFDWQNCSLVFRSQTYSANEIDLQL--- -----------------TVEENQTIEWIVIDPEDFTENGEWAIKHKPAKRLVNDRFTKDDLE--------YQ E----VIFYLIIQRKPLFYVINIITPCVLISSIGLLVYFLPA-KAGGQKCTLSINVLLAQTVYLFLIAKKVP ETSQAVPLIVKYLTFLMCMEIIIVMNCVIVLNVSLRTPNT-HT-MSHKVRELFLKWLPRYLG---MHL---- ------------------------------------------------------------------------ ---NPSEEVWCAPVPRRKSSL-----------------------------------------RLIFKADEYM ----------------------LRKARSELMFERQKERDGLMKAVLQKIGS--------------------- ---------------------------------------------------------RLENGTIHDICYSLS H-----------------------------------------------------TAPQIRKCVE-ACNYIVK STQEQNEFD-SENEEWILVGKVIDRVCFWIIFCVFICGTVGVFL--MAHFNQAPSDPFPGDPKKYLP----- ------------------------------------- >WesternClawedFrog_5_1/1-510 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----MDTVLLLVLICISAALCRN---------EEE-GLLNDLM-----KNYNKNLRP-AEKDGD-IVSVSIK LTLTNLISLNEREEALTTNVWVEVQWRDYRLSWDP----NEYYGISM-MRIP--ST---SVWLPDVGLEN-- -NVD-GTF-DIALYANTLVSSDGSMYWLPPAIYRSSCPVVVTYFPFDWQNCSMVFQSQTYSANEIELLL--- ------------------TVDEQTIEWIEIDPEAFTENGEWAIKHMPAKKIINH---RLTPDD-----LNYQ Q----IVFYLIIQRKPLFYIINIIVPCVLISFVSILVYFLPA-KAGGQKCTVSINILLAQTVFLFLIAQKIP ETSTAVPLIVKYLTFLMVVTITIVANAVIVLNISLRTPNT-HS-MSSTVRELCLRTVPRLLR---MHL---- ------------------------------------------------------------------------ --RPSDAAPPLAPLMRRSSSV-----------------------------------------GLMIKADEYM ----------------------LRKPRSQLMFEKQKERDGLMKVVLDKIGR--------------------- ---------------------------------------------------------GMENNTSDDLVHSLK H-----------------------------------------------------AAPEIRACVE-ACCHIAS ATREKNEFK-SENEEWILIGRVIDRVCFLVMCFLFFLGTIGTFL--AGHFNQAPALPFPGDPKLYQPST--- ------------------------------------- >Chicken_9_2/1-514 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M RCSDLLLLFLLAFCVLPGISCRN---------QEE-KLLQDLM-----TNYNRHLRP-ALRGDQ-VIDVTLK LTLTNLISLNEREETLTTNVWIEMQWSDYRLRWDP----DKYDDIQQ-LRVP--ST---MVWLPDIVLEN-- -NID-GTF-EITLYTNVLVYPDGSIYWLPPAIYRSSCSIHVTYFPFDWQNCTMVFQSQTYSANEINLLL--- -----------------TVEEGQTIEWIFIDPEAFTENGEWAIKHRPARKIINS-GRFTPDDI------QYQ Q----VIFYLIIQRKPLFYIINIIVPCVLISSMAVLVYFLPA-KAGGQKCTVSINVLLAQTVFLFLIAQKVP ETSQAVPLIGKYLTFLMVVTVVIVVNAVIVLNVSLRTPNT-HS-MSQRVRQVWLHLLPRYLG---MHM--P- ------------------------------------------------------------------------ -----EEAPGPPQATRRRSSL-----------------------------------------GLMVKADEYM ----------------------LWKARTELLFEKQKERDGLMKTVLEKIGR--------------------- ---------------------------------------------------------GLESNCAQDFCQSLE E-----------------------------------------------------ASPEIRACVE-ACNHIAN ATREQNDFS-SENEEWILVGRVIDRVCFFIMASLFVCGTIGIFL--MAHFNQAPALPFPGDPKTYLPP---- ------------------------------------- >AnoleLizard_scaffoldGL343304_1/1-512 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MSWPNVVFLAFSFLTVALSRN---------QEE-KLINDLM-----ADYNRNFRP-ARDKGD-IIDVSLK LTLTNLITLNERDEALTTNVWVELKWNDYRLQWDP----NDYDNIKC-LRIP--ST---MVWLPDIVLEN-- -NID-GVF-DVALYANVLVSPSGSITWLPPAIYRSVCSIIVTYFPFDWQNCSLVFQSQTYNAHEINLLL--- -----------------TVEEEQTIEWIFIDPEDFTENGEWAIKHRPAKKIVNAGS-FTPDDI------EYQ Q----IVFFLIIQRKPLFYIINIIIPCVLISSVAVVVYFLPA-KAGGQKCTVSINVLLAQTVFLFLIAKKVP ETSQDVPLIGKYLTFLLVVTITIVVNAVIVLNVSLRTPNT-HS-MSKRVRQVFLHLVPNFLG---MHT---- ------------------------------------------------------------------------ --RRPNNMAMGPQLLRRRSSL-----------------------------------------GLMAKADEYM ----------------------LWKARSELLFERQKGRDGLMKLLLAKIGE--------------------- ---------------------------------------------------------GLENGCPQDFCSNLR N-----------------------------------------------------AAPEIQACVD-ACNHITK TLKEKSEFD-SENEEWILVGRVIDRVCFLIMASIFVFGTIGVFL--MARFNQAPEAPFPGDPKRYLP----- ------------------------------------- >HighHimalayaFrog_scaffoldNW017307158/1-515 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MDGRLPFWFLLPLLSYSLASE----------ES-QLLNDLF-----EDYNKNSRP-VRSISD-IVEVRLK LTLTNLISLNEKEETMTTNVWLQLEWDDYRLTWNE----SDYAGISV-LRVS--PD---MVWLPDIVLEN-- -NVD-GQF-EVAYYANVLVYSTGYISWLPPAIFRSACAVEVTYFPFDWQNCTLVFRSKTYTAKEITLLL--- ----------------AFAESGDLLERVDIDPEAFTENGEWAIKHCPAWKYVNNRYTEEDLQ--------YQ E----INFGLVIQRKPLFYIVNIIVPCVLISSLVVLVYFLPA-KAGGQKCTVSISVLLAQTVFLFLIAQKVP ETSLNVPLIGKYLIFVMIVSTIIVLSCVIVLNVSLRTPST-HN-LTAVMKRRLLEVLPRYLH---MKI---- ------------------------------------------------------------------------ ---EPCEEEEQTPKERRKSSL-----------------------------------------GIMLKAEEYV ----------------------LKKPRSELMFERQRERHGLSRDSRGHRVD--------------------- ---------------------------------------------------------GFDVGVTTPLFRNLA H-----------------------------------------------------IAPEIKECVE-ACNFITS STKDQNKTS-AEMENWIMIGKVIDVLCFWGALPLFVVGTFAIFI--TGHLNSAPEHPFKGGGRQFPLCTTSS ------------------------------------- >Coelacanth_scaffoldJH127111/1-471 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----MKLTFSLLLLFLFKAVCGN---------LET-KLIEGLF-----AGYDKSTRP-AENVDD-IVDVMLK LTLTNLISLNEKEETLTTNVWIEI------------------------------------------------ --ID-GNF-DIAYYANVLVYPDGSIYWLPPAIYRSTCSITITFFPFDWQNCSLVFRSQSYSASEIRLLL--- -----------------AVENSTEIEWVDIDPSDFTENGEWAIKHKPARKVINKQF--TPDDL------EYQ E----IQFYLIIQRKPLFYIINIIIPCVLISSLVVLVYFLPA-QAGGQKCTVSISVLLAQTVFLFLIAQKVP ETSLSVPLIGKYIIFVMFVSTLIVTNCVIVLNISLRSPST-HI-MPPKVKHIFLEVLPQYLG---MHL---- ------------------------------------------------------------------------ ---EPSEDSWDVPRPRRRSSF-----------------------------------------GIMLKAEEYI ----------------------LKKPRSELMFERQKDRHGLKLSHYNKLD---------------------- ---------------------------------------------------------GIDVGTTANLYKSLA H-----------------------------------------------------LAPEIKECVD-ACNFIAK NTKENNDSG-PEIESWVLIGKVIDKVCFWVAILLFSIGSVGIFM--MGKLNEVPEYPFPGEIKKYTPE---- ------------------------------------- >SpottedGar_LG2_1/1-443 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------MRPR SLTVRLVLAVVLFSLCALHVCEN---------QES-RLLKDLM-----SGYNKRIRP-ARQPGD-KVQVQVK LTLTNLISLNEKEEALTTNVWIEIQWNDYRLAWNS----SEHDDISV-VRVP--YN---MVWLPDIVLEN-- -NID-GKF-DVAYYANVLIHPDGSMYWLPPAIYRSACSVEVTYFPFDWQNCTLVFRSQTYSANEIDIIL--- -----------------AVDTGKTIEWVDIDPEAFTENGEWAIRHRPARKVINRRY--TPDDL------EYQ E----VHFNLIIQRKPLFYIINIIVPCVLISSLVVLAYFLPA-QAGGQKLTVSISVLLAQTVFLFLIAQQIP ETSLSVPLIGKYLIFSMFVATLIVTNCVIVLNISLRSPNT-HT-MSHGIRHV-------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------GTTASLYKSLA H-----------------------------------------------------CAPEIKECVD-ACNFIAQ STREQNDIG-SEMESWVLIGKMIDKVCFWAAILLFSIGTIGIFL--MGHYNNVPEYPFPGENKKYAPN---- ------------------------------------- >Zebrafish_5_chrne/1-517 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------MAVA ERFGRTCVVAIALLATVLQVTGN---------EES-QLIADKF-----KNYSKNIRP-ARHADE-KVKVQVK LTLTNLISLNEKEETLTTNVWIEIQWHDYRLAWNT----SEYHDIEQ-IRVP--YY---TVWLPDIVLEN-- -NID-GKF-DVAYYANVLISSDGSMYWLPPAIYRSTCAIEITYFPFDWQNCTLVFRSQTYSANEIDIVL--- ----------------AEDENGKPIEWVDIDPEAFTENGEWAIKHRPARKLTNQRY--SPDDL------EYQ E----VYYNIIIQRKPLFYVINIILPCSLISSLVVLAYFLPA-KAGGQKLTVSISVLLAQTVFLILISQKIP ETSLSVPLIGKYLIFVMSMTTLIVTNCIIVLNYSLRSPST-HN-MSQSIKHIFLEVVPRYLG---MAP---- ------------------------------------------------------------------------ FVDEGDQGGVYEMRERRRSSF-----------------------------------------GLMQRAEEYV ----------------------LKQPRSEMMFDKQRERHGLMRTIVD------------------------- ---------------------------------------------------------EIDVSSTANLYKSLA K-----------------------------------------------------TAPEIKECVD-ACNFIAE STKQQNDTG-SEMESWVLIGKMIDKVCFWAAISLFSIGTIAIFL--MGHYNQAPEYPFAWENKKYVPE---- ------------------------------------- >Medaka_14_1/1-518 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------MMAV CNFWIFSGVLTILWLSLGLVHCN---------EES-QLIGDLF-----RNYNKNIRP-VEHPED-KVQVMIK LTLTNLISLNEKEETLTTNVWIEIQWTDYRLVWNT----SQYYGIKT-IRVP--YN---TVWLPDIVLEN-- -NID-GKF-DVAYYANVLISNEGWMYWLPPAIYRSTCAIEITYFPFDYQNCTLAFRSQTYSAKEVDLVL--- ----------------ATGDEDVTIEWVDIDPEAFTENGEWAIVHRPARKVINTRY--SPDDL------EYQ E----IIFNLVIQRKPLFYIINVILPCSLISSLVVLAYFLPA-QAGGQKLTVSISVLLAQTVFLFLIAQKTP ETSLAVPLIGKYLIFVMCVTTLIATNQIVVLNFSLRSPST-HT-MSYSIKHLCLEMVPRFLG---MSP---- -----------------------------------------------------------------------L VDDSEVTAEVNGIRERRRSSF-----------------------------------------GLMQRAEEYV ----------------------LKQPRSEMMFDKQRERHGLTRSIVD------------------------- ---------------------------------------------------------NIDVSSTANLYKSLA Q-----------------------------------------------------AAPEIKQCVD-ACNFIAE STKQQNDIG-SEIESWVLIGKMIDKVCFWAAMLLFIVGTVGIFL--TGHVNKAPEFPFPGEDKKYVPR---- ------------------------------------- >Fugu_15/1-516 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------MAA PGLGMFYGFVLFLGTLIPEVQSN---------EET-ELIKDLF-----KDYNKNIRP-VVHPED-KVEVQIK LTLTNLISLNEKEETLTTNVWIEIQWLDYRLSWNE----SKYYGIQV-IRVP--CK---TVWLPDIVLEN-- -NID-GKF-DVAYYANVLISSNGWMYWLPPAIYRSTCSIEITYFPFDYQNCTLAFRSQTYSANEVDLIL--- ----------------ALTEENGTIEWVDIDPEAFTENGEWAIVHRPARKMVNMRY--SPDDL------EYQ E----ILFNLVIQRKPLFYIINLILPCSLISSLVVLAYFLPA-QAGGQKLTVSISVLLAQTVFLFLIAQKVP ETSLSVPLIGKYLIFVMCVTTLIATNQIVVLNFSLRSPNT-HT-MSQTIKHVFLEMVPRFLC---MPP---- -----------------------------------------------------------------------L VDESEATTEVNGIRERRRSSF-----------------------------------------GLMQRAEEYV ----------------------LKQPRSEMMFDKQRERHVD------------------------------- ---------------------------------------------------------NIDVTSTANLYKSLA Q-----------------------------------------------------AAPEIKQCVD-ACNFIAD SKRQQNTIG-SEIESWVLIGKMIDKVCFWAAILLFIIGTVAIFL--MGHFNRAPDFPFPGQNKKYVPSSTET F------------------------------------ >Stickleback_VII_3/1-517 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------MAE SRFWIFFGVVAVLGTLTARVQCN---------EES-ELIRDLF-----KGYNKNIRP-VVHPED-KLTIQIK LTLTNLISLNEKEETLTTNVWIEIQWVDYRFVWNT----SNYHGIDV-IRVP--CK---TIWLPDIVLEN-- -NID-GKF-DVAYYANVLISYDGSMYWLPPAIYRSTCAIEITYFPFDYQNCTLAFRSQTYSANEVDLIL--- ----------------AVGDEMETIEWVDIDPQAFTENGEWAIVHRPGRKMINPRYTPDDLE--------YQ E----ILFNLVIQRKPLFYIINIILPCSLISSLVVLAYFLPA-QAGGQKLTVSISVLLAQTVFLFLIAQKIP ETSLSVPLIGKYLIFVMSVTTLIATNQIVVLNFSLRSPST-HT-MSNTIKHVFLEMVPRFLG---MPP---- -----------------------------------------------------------------------L VDDTEVTTVVNGVRERRRSSF-----------------------------------------GLLQRAEEYV ----------------------LKQPRSEMMFDKQRERHGLTRSIVD------------------------- ---------------------------------------------------------DMDVSSTANLYKSLA Q-----------------------------------------------------AAPEIKQCVD-ACNFIAE STRQQNSIG-SEIESWVLIGKMIDKVCFWAAISLFIIGTVWIFL--TGHFNRAPEFPFPGQSKKYVPS---- ------------------------------------- >ChineseSoftshellTurtle_scaffoldJH206417/1-437 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------GAPGRN---------EEL-QLYEKLF-----ANYDKNTRP-VRHPDD-IVDVQLM LTLTNLISLNEKEETLTTNVWIKIEWVDYRLNYSK----SEFEGIRS-LRVP--SD---MVWLPDIVLEN-- --------------------------------------------------------SQTYSANEVNLQL--- ---------------SINEETARPFDEIDIDPEAFTENGEWAIRHRPARRVLHP---ELGREA-----LGFQ E----IRFSLIIQRKPLFYIINIIVPCVLISSLVVLVYFLPA-QAGGQKCTLSISVLLAQTVFLFLIAQKIP ETSLSVPLIGKYLMFVMGVATLIVMNCVIVLNVSLRTPNT-HC-MSEQLKHVLLEVLPRYLG---------- ------------------------------------------------------------------------ SALEPSGDPWAAPPTRRRSSF-----------------------------------------AIMLKAEEYI ----------------------LKKPRSELVFEHQGQRHGLHRSPTPD------------------------ ---------------------------------------------------------GVDVGITSTLYKNLA S-----------------------------------------------------AAPEIRECVE-ACNFITE TTREQNASS-AEMENWVLIGKVIDKLCFWAALLLFTIGTLGIFL--MGHFNQVPDNPFPQLPD--------- ------------------------------------- >AnoleLizard_scaffoldGL344523/1-367 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------QWEDYRLNYSS----ADFGGIGT-IRVP--AD---MVWLPDIVLEN-- -NID-GNF-EVAYSANVLIYEGGSMYWLPPAIYRSTCSIEVTFFPFDWQNCSLVFRSQTYSAKEVQLTF--- ---------------GPDDVTGVPVKDIIIDPAAFTENGEWAIRHRPARQLLAPVSGQEAPG--------FS E----MHYFLIIQRKPLFYIINIIIPCVLISSLVVLVYFLPA-ESGGQKCTVSISVLLAQTVFLFLIAQQVP ETSLSVPLIGKYLLFVMVVATIIVTNCVIVLNVSLRSPST-HA-MSRRLKHVIMEVLPEVPG--------P- ------------------------------------------------------------------------ --------------------------------------------------------------GSTPAYITVL ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------VLLNCCIILL-NGQLGLE APQETPKGQ-QEMENWVMIGQVIDKLCFWAAILLFSIGTFAIFY--MGLLNTAPDNPFPGMEEP-------- ------------------------------------- >BurmesePython_scaffoldNW006538161/1-511 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MKAVS SLGGSLWMGLLLCGAALGSPEGN---------KEL-QLFNRLF-----ANYNKSTWP-VRRVGE-VLQVSVK LTLTNLISLNAKEETLTTNVWITQEWVDYRLNFSS----EEYDKE---LRVP--SD---LVWLPDIVLEN-- -NID-GNF-DVAYSANVLISPGGNMYWLPPAIFRSSCPIEVTFFPFDWQNCSLVFRSKTHNAREVELQY--- ---------------GLDDNTQEPVKEVIIDPEAFTENGEWTIRYRPARLILAP--VPGLEAP------GFS E----IHYFLIIQRKPLFYTINIIVPCVLISSLVVLVYFLPA-QAGGQKCTVSISVLLAQTVFLFLIAQKVP ETSLSVPLIGKYLLFVMTVATLIVMNCVVVLNVSLRSPST-HL-MSPNLKHLFLKILPRYLG---STV---- ------------------------------------------------------------------------ --GPAGDEPQDAPRPRRRSSF-----------------------------------------SIMVKAEEYI ----------------------LKKARSEVLFEHQGQRHGLQRAPNYG------------------------ ---------------------------------------------------------GLDVQMTTILYKNLS S-----------------------------------------------------LAPEIKECVD-ACNFITK STKDQSADG-AEIESWVLIGQMIDKLCFWIAILLFTTGTLAIFF--MGHLNTVPEDPFSGQED--------- ------------------------------------- >C.elegans_I_1/1-551 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----MLFRLILLLFSIRLCSFT----------AYK-SLFETLL-----ARYNKIAFP-SGEFNN-TLTIEFK LRLDQIVDVHEKDQVITLKGTLIHHWLDYRLSWNP----DEFGNITL-MHFP--GE---MLWLPDIILYN-- -NAH-GSP-WVSETTQVHVSFEGRVTWQPPVVYDAFCNIDIEWYPYDLQICELKFGSWTYGGSQLNLIH--- ------LTTDQANESTDATGDNVWKVERGVDLSNYQESVEWDLLSVEGIRHKKW-Y-PCCDYP-------SI D----ITYYLHIRRKKLFYTVNMIIPCVCLASMTLWVFYLPC-ES-HQKIQLCISVLVALTLYFLMLIDIIP PTSIVTPLILKYLSFTMIMVALSVTCTVFIQNIHYRAYY--QP-MPRFVKHWFIEKLGKKLL---ISR---- ------------------------------------------------------------------------ -KTEQAQYHRTAQHVKQVNALSAMNILEKQ----------------------FQKTLFELEIATMAKKTVTA APKTVNSIFLELPMMNRSVSVKIRKPSVKAVKNRMRRLLSIDMTDDIRG----------------------- ---------------------------------------------------------KETEEISPETTKDTD P-----------------------------------------------------DREKLRKAEK-NIHFIAK TLTDERRAQ-EAEADWQFVSLVIDRMLLIIFSFTITIGTILTIFSAPTMRDNREPIAINP------------ ------------------------------------- >CionaSavignyi_reftig25/1-474 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----MLRRIILAMALTSLVAAK----------SRY-ELSYDLS-----VGYDNKVRP-SDSYNK-SVKVVFK LFFNQLLDVNEVNQKMETKFWVYHKWIDPRLTWNP----DNYEGLEY-MYLP--IT---NIWLPEFVLYN-- -NAD-GDF-AVSQSVKAKVDYKGTVEWKPPAIFKTFCEIMVAQFPFDTQNCTMKIGPWSHGQDLLDMVN--- -----------------SDWDVKNHTCELPEMKMYEESGEWLVLKTGCWKHYIK-Y-DCCLGP-------YV D----MTYYFILQRRPLYLVVNILFPTMLFSYLTCAVFYLPS-DA-GEKMTLSISLLLSLIVFLLVIVEAIP STANGVPLLCQYILFTMILVCLSIMITVGVLNVHYRGPAT-HV-MSKRMKKIFMVWLPKFIF--------S- ------------------------------------------------------------------------ --------------------------------------------------------------STMKRLDPYK --------------------------DDKILSSEPPKPYNE------------------------------- ---------------------------------------------------------ISDLSGRIPQPERPH L-----------------------------------------------------IGSDVKSAID-GVKYVSE CYRDQRDSQ-QKEDEWKYVAMVLDHFLLYIFILACVVGTVGIFG--KRLWEVSWEEELYKNSGDKCILNC-- ------------------------------------- >CionaIntestinalis_7_1/1-478 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----MIVLRLLVMGALAYVSVAK---------TRY-DLSGDIM-----QGYDAKVRP-SDSYNN-SVKVVFK LVFNQLLDVSEVNQKIETKLWVYHKWMDPRLSWVP----EDYENLEY-IYLP--TT---NLWLPELVLYN-- -NAD-GDF-AISQFTKAKVDYTGMVEWKPPAIFKSFCEIMVAEFPFDTQNCTMKIGPWSQGQDLLDMVN--- -----------------SDWEVKDHMCEPPDETMYEESGEWLILKTGCWKHYIK-Y-DCCRGP-------YV D----MTYYFILQRRPLYLVINILFPTMLFSYLTCAVFYLPS-DA-GEKITLSISLLLSLIVFLLVIVEAIP STANGVPLLCQYILFTMILVCLSIMITVGVLNVHYRGPAT-HV-MSDRMKKIFMVWLPKFIY--------S- ------------------------------------------------------------------------ --------------------------------------------------------------STMKRLDPYK --------------------------EEKMLAGRPPKPYKD------------------------------- ---------------------------------------------------------ISDLSGRSPKPDEPH L-----------------------------------------------------IGSDVKTAMD-GVDYVSE CYKDQREGQ-QKEDEWKYVAMVLDHFLLYIFILACVVGTVGIFG--KRLLEFMSEQELFKNLGNECILKCQS D------------------------------------ >C.elegans_X_6/1-531 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------MWIP QRISHIFLLVIFILHIVTINANK---------HVS-QLLENLL-----TDYNKAVRP-VHNASD-ALKVKFG ANLCRLIDVDEVNQVLTTSLWLEMQWYDKKLTWNP----TDWGGVEY-IHIP--SD---QIWIPDIVLYN-- -NAD-GEP-HITITSLAKIDHHGRVVWQPPSIYKSFCPINIKYFPYDWQTCEMKFGGWSNDGETLDLYQ--- ---IPVDVDDIPQVKRQDDGVEFLYLEKGLGLSFYHESAEWDLLSATSSRYAQI-YPGCCGQQ------YYI D----IKYRIIIRRKAIFFTVTLTIPCMLIANVTPFVFLILP-NE--HKMTYSISVLVAFSVFYLVLIDLIP PTSLSLSLIGIYLLFTLLMVSVSIILSVVTINMYRKQAFS-SG-MSHWQRWLFVQRLPKLLR---LKT---- ------------------------------------------------------------------------ LEHTLGPDEGSETTTPRTGSV-----------------------------------------SVTASVTQRT ----------------------LNPNNNSPVFPPQRLRL--------------------------------- ---------------------------------------------------------LSLVQMDEALKQRCA A-----------------------------------------------------DNLDLFRKIAGHLKIISA HFHNQQMEG-KITEEWQLMSLVIDRIFLILFLAVSMAANIMFVYNSPTLFDDRPSLVPSVAHKPLSGGTINV LNT---------------------------------- >C.elegans_X_5/1-537 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MNFAFLLRIFVYAGLFFYVNPNR---------YAD-QMYEDLL-----YYYNKNVRP-IKNASE-SVKVKFG SSLIRIIDVDEVNQVLTTNLWLEMQWFDYRLMWDP----GRWGKIRK-LHVP--VD---QIWIPDILLYN-- -NAD-GEP-HITIMSDAIVYYNGLVVWKPPSIYKSFCSIDIEYFPYDTQTCWMKFGGWTYNGFLLDVRQ--- --------LPVEEWTLVVTTRKLQVCAHASSISFFFRSLEWDLMELNSARHEKI-YAGCCGQD------FYI D----ITFKIEIRRKTLFYTINLMIPCTMFAILTSIVFYVPPIEH---KMTFSISILVTLTVFYLILIDLVP PTSLVIPLIGKYLLFTMFLVSISIMLSVISLNFYRRDGSS-FP-MPHWMKVVFIHTLPRYIC---IKT---- ------------------------------------------------------------------------ --------------------------------------------------------------AEEDDGSDRG -----------------------SSISDIGPFMDSRRPSPFFITVN-------------------------- ---------------------------------------------------------ERQLNGRLSELKKKG M-----------------------------------------------------HPDLIRNMIQ-NVEFIAE YFNSLKKED-KVSEDWSYVANVIDRIFLIIFSIMNVVGTWVILLNSPALFDNRTPLFINSVARPLSGDTFEH FINENFTQLAWWASTIKNSTTDVSDSDLCPIKYQ--- >C.elegans_X_7/1-573 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------MLYKKRLQMFSFN WALILLVAVGGTNAFKIKRTAKD---------LES-QLYEDLL-----FDYNKVPRP-VKNSSD-ILTVDVG ASLIRIIDVDEKNQVLTTNLWLEMKWNDAKLTWTP----EKYGGLKT-LHIP--SD---FIWTPDLVLYN-- -NAA-GDP-DITILTDALVTFEGNVYWQPPAIYKSFCPIDVTWFPYDSQKCEMKFGTWTYTGRYVDLKQ--- -------LPQEEVVTITKDDNDVEFMQQGMDLSFFYRSAEWDLLSLTSERHSVL-YASCCGPE------KYV D----ITYYFGLRRKTLFFTCNLILPCFLISILTTFVFYLSD-----HKITFSISILVTLTVFFLVLIDLMP PTSLVIPMFGRYLITTMILVALSTVVSVITVNFRFRSGSA-HK-MSPWIRAVFLKFLPKILL---MSR--P- ------------------------------------------------------------------------ ---EKGEVTKQPPLVNAASLV------------------------------------GSNYATAAKAANEYR NKAKGKNNDLMSLRGKPSSQAVLNNTFDMRMRNNDSTVENRLKPYLCAQNNNA------------------- ---------------------------------------------------------PTVAFRKTKRQKSKS V-----------------------------------------------------DDVVFMNLLN-QVRFIAE HFRHNELEG-EISDDWTFVAMVLDRLFLIIFSVLNV-GTVFIILESPSLYDYSKPMNITVPNKPLGQANFYS SWNLK-------------------------------- >CionaIntestinalis_scaffoldNW004190501/1-483 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MRLLLFMYFYLNFAKGNTYTETE---------HKQ-NLIHYLFPNNTDRSYNKWVRP-VKHATD-VLRVEFQ LVIRQLLDVDEKHQLMSTNVWMKQKWIDRNLRWVP----DEYGNITS-IRIP--SE---WLWLPDVVMME-- -NTD-GNF-TVSHMTSAHVRHDGSVAWQPPASLKSWCYIDVTYFPFDVQNCTMKFASWTYGNNTVQLVP--- -------------------------METKVDVTNLLHNGEWDIVDTHVEHTSSS-DSSLYIKRNTIETIEVM FGQNGISYCFVMKRLPLFYIVFLITPCLGISFLTALVFYLPS-DS-QEKITLCISVLLAHTFYLLVITEIIP STSNAIPLIGEYLLFTMIFITLSIIVTTTVINVHYRSNTT-HRPLPKHLRYVLLTVAPSILC---LRK---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------FSSRIQWNLPLINLSASILQRR--------------------------- ---------------------------------------------------------LKECEDVTTSPSSRP Y-----------------------------------------------------PNPEVITAYQ-CVRFLVR RIKKKVRHR-REKEEWMYAAMVMDRIFLAVFLFVSLVGTIVLFL--PALAKYHEHSGSREEMANH------- ------------------------------------- >C.elegans_X_2/1-575 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------MKKTVKILLILITVFLKVHCNGGHDDEAADFLSHT NIDDPNNSSDPNKNSDQGDTMGE---------DED-RLVIDLF-----REYNFLIRP-VKNVSSPPVVVDFG VAMILLINVDEKNQILQTNVWLTMKWNDFQLAWNP----AEYGNISN-LHVP--SD---RVWLPDIVLFN-- -NAD-GNY-EVSFKSNVFVDHHGDVTWVPPAMFKSSCRIDVEWFPFDEQCCTLVFGSWTYNSEEVRLHW--- -----------------------YNNIQAVQLHDYSYSGIWDVIDVPGQLVHKP---DLKENK--------- -----MVFNVVIRRKTLFYTVILIIPTVLMAFLSVMAFYLPV-DS-GEKVSLTISLLLALVVFLLLVSKILP PTS-NIPLMGKYLLLAFVLNITAVVGTVVIVNIYFRSALS-HK-MPTWVRKVFLEFLPHLLV---MKR--P- ------------------------------------------------------------------------ ---ERIPIFNGYFVEEYCASE---------------------------------------IFDASLVMPSMT ATMLPFLQVTTNLKAASSTSSGQSSEHHENCSKWKKRLSIRMSKRRAPRARLDDDSED-------------- ---------------------------------------------------------IIDDTNGNHVDSLQE K-----------------------------------------------------ISKEMKTTVE-AIAYIAE HMKREMSLK-KMRDDWKYVAMVLDRLILLIFFGVTLGGTLGIICSAPHVFDFVDQEAIISKLNAKYLPSDMY S------------------------------------ >C.elegans_X_3/1-487 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M QKIWLFSIITIFLITELQCYPNS---------AEE-RLLSYIF-----DGYNSLIRP-VLNASSPPIEVFFS LAFVLLINVDEKNQIMQTNVWPTMKWNDYQMQWDP----REFDGIKT-IRVP--PD---KVWLPDIVLFN-- -NAD-GNY-LVSFYSNVVVEHTGDMLWVPPAVYKSSCLIDVEFFPFDEQVCSLTFGSWTFRKDELQLSY--- -----------------------LSGKRHVELNDYLPSGVWDLIDAPGLLIDERSK---------------- -----ISYQIKIRRKALFYTVILIMPTVLMAFLSMMVFYLPA-ES-SEKITLAISILLALVVFLLVVSKILP PTSSTIPLMAKYLLMTFIMNMITIMVSVIIINVYFRGPAT-HI-MPNWVKTVFLKFLPVLFV---MRR--P- ------------------------------------------------------------------------ -----------ESTEKELAKM-----------------------------------------KREKRERRSM ------------------------KSALKTFFKRNDAKISE------------------------------- ---------------------------------------------------------QPKQTSRKDGSSSEE K-----------------------------------------------------LSSDAKKAIE-AIEYITT HLTHDNAFK-RQREEWKFVSVVIDRLLLYLFFAVTTGGTVGILLSAPNVFEQVNQTSVIERLKQQAAEEMLN S------------------------------------ >C.elegans_I_5/1-493 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MRTNR LSWILVLSVVIFLVIINTINASD---------DEE-RLMVDVF-----RGYNSLIQP-VRNSSELPLIVKMA LQLVLLINVDEKDQVMHTNVWLTLQWHDFQMKWNP----VNYGEIKQ-IRVS--PD---KVWLPDIVLFN-- -NAD-GNY-EVSFMCNVVINHKGDMLWVPPAIYKSSCIIDVEFFPFDEQVCTLVFGSWTYNENEIKLEF--- ------------------------VQAELVDVSEYSASSIWDVIDVPASLVNKRSR---------------- -----IEFQVRIRRKTLFYTVVLIIPTVLMAFLSMAVFFLPT-DS-GEKITLTISVLLSIVVFLLLVSKILP PTSSTIPLMAKYLLLTFVLNVITILVTVIIINVYFRGPRT-HR-MPQWVRVVFLQFLPKLVC---MKR--P- ------------------------------------------------------------------------ --------KSASERSAVRSGM-----------------------------------------AQLPGVGQFT ----------------------LSPSAHHPLCPSADDRT--------------------------------- ---------------------------------------------------------TTIRNTASNETSAYY P-----------------------------------------------------LSTDALRAID-AIEYITE HLKRDEQHK-SFRDDWKYVAMIIDRLLLYVFFGITVGGTCGILFSAPHVFQRIDQQEMLDRLKEKYDTASNI P------------------------------------ >C.elegans_IV_2/1-507 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------MMLGGGGGCGAGG TWLGFLVFLAVSLRNHSTCEDID---------AED-RLMVDLF-----RGYNSLVQP-VRNRSELPMIVKIG MQLVLLINVDEKEQVMHTNVWLTMKWDDFQLKWDP----RDYANITQ-IRVA--PE---KVWLPDIVLFN-- -NAD-GNY-EVSFMCNVLILSTGTVLWVPPAIYKSSCIIDVEFFPFDDQLCSLTFGSWTYNRDEIKLDF--- ------------------------LTSDRVDFSEYSTSSIWDMMDGPAVLTSDRSR---------------- -----IEFQIRIRRKTLFYTVVLILPTVLMAFLNVTVFYLPT-AS-GEKMGLTMNVLLSIVVFLLLVSKILP PTSSSIPLVAKYLLLTFVLNIITIMVTTIICNIYFRSPIT-HR-LPPWVRKVFLDILPLLMC---MQR--P- ------------------------------------------------------------------------ -------HRKNVIQRSHRRLL-----------------------------------------ETGPSVEENP ----------------------MRSGEHHPLCRHTHNQ---------------------------------- ---------------------------------------------------------DSCRRVRIQSDELDD E-----------------------------------------------------LSPEAQRAID-AIEFITE NRRDEEITK-QFRDDWKFIASVVDRFLLYGFFGATVGGTIGIIFTAPSVFETFDENATLVKLKQLYDMGLAN DTVLGIF------------------------------ >CionaIntestinalis_scaffoldHT000037/1-774 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MDFSFL KLVQWKSLCILACLHIGNTDASK---------TDE-KLSQFLF-----SNYNKHIRP-ARTLGD-VTNVTFY LTLLQLISVTEKSEEMTTSQYVTIRWEDPRLIWNP----KDFGGVTQ-IRLP--SQ---LFWKPDLVLYN-- -NND-GEY-DTTVPVNALLNHTGMVEWLPAAIYKSACKIKVDLFPFDWQNCTMKFRSFTYDKTELYITS--- -----------------------AYNKVVVDKAAYRDNGEWTIIHCPIKTNEDV------NDP------SYQ D----ISLYFIIQRKPLFYIINIIIPCVLISSLSVLVFYLPS-GS-SEKMTMSISVLLGLTVYLLLLAKRVP ETSLGVPLIGAYLLFTMLTVTLSIIFSVVVLNIYHRTPST-SE-MPEWVRSLFMGTLPDLLR---MEK--P- -----------------LSTRRLLLQTERRKLDDPIVSKNPYTHIARQTERDALLTDAYVEQAIPTAEQNLI ILEEYKRNQQLVSSISRRSQHLRSRRTNKANDFSENGRKTEKNRRHRKQRQSCHDDQSWKYHGDDLNTTQFL QENIPMNLSEDGWGKEPIVCPEKYLPRSKSCSFDSKKHCAYIKEYQNHGDIATSLPLLGDSHRNNYDQLKED QGNANPVQDSFENEELYLYKTHNEKIWCSKPRRTDLKGQTRIRNRPRPFQNLRSPHLKPRENGYHSHNTKHT SGDIKSPNVTTYESLFIDEEEQDASHYNTPTSTGAANCFESVEFVTNECKSVGKLSEEALLAAS-AVDFIAE NMKTTDKMK-IMIEDWHFVATVVDRLLLWIFMLVFLAGTLYFFI--KATLNAPPQHPFEDNDPKYAMCWKTD EHHKYHLLE---------------------------- >Fruitfly_3L_1/1-521 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------MES SCKSWLLCSILVLVAFSLVSASE---------DEE-RLVRDLF-----RGYNKLIRP-VQNMTQ-KVGVRFG LAFVQLINVNEKNQIMKSNVWLRLVWYDYQLQWDE----ADYGGIGV-LRLP--PD---KVWKPDIVLFN-- -NAD-GNY-EVRYKSNVLIYPTGEVLWVPPAIYQSSCTIDVTYFPFDQQTCIMKFGSWTFNGDQVSLAL--- -----------------------YNNKNFVDLSDYWKSGTWDIIEVPAYLNVYE---GDSNHP------TET D----ITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPA-EA-GEKVTLGISILLSLVVFLLLVSKILP PTSLVLPLIAKYLLFTFIMNTVSILVTVIIINWNFRGPRT-HR-MPMYIRSIFLHYLPAFLF---MKR--P- -----------------------------------------------------------------------R KTRLRWMMEMPGMSMPAHPHP-----------------------------------------SYGSPAELPK ----------------HISAIGGKQSKMEVMELSDLHHPNCKINRKVNSGGELG------------------ ---------------------------------------------------------LGDGCRRESESSDSI L-----------------------------------------------------LSPEASKATE-AVEFIAE HLRNEDLYI-QTREDWKYVAMVIDRLQLYIFFIVTTAGTVGILMDAPHIFEYVDQDRIIEIYRGK------- ------------------------------------- >C.elegans_I_2/1-511 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------MR SFWLFLLLLLFCISFIKLTEGNE---------DAK-RLYDDLM-----VNYNRHRRP-STSPNK-PLTIKLK LRLSQIIDVHEIDQIMTCSVWLKQTWIDRKLSWDP----VNYGGVNV-LYVP--YE---MIWVPDIVLYN-- -NAD-SNY-NITISTKATLHYTGEVTWEPPAIFKSMCQIDVRWFPFDEQQCHLKFGSWTFSENLLSVEL--- ---NEPSLRYEEEIDEKGIIDNVTVAEDGIDLSDYYPSVEWDIMSRVAKRRAKN-YPSCCPQS------AYI D----VTYYLQLRRKPLFYTVNLVFPCVGISFLTILVFYLPS-DS-GEKVTLCISILVALTIFFLLLTEIIP ATSITLPLIGKYLLFTMVMVTLSVVVTVISLNLHFRTPTT-HL-MPNWVKKVFLKWLPKLLF---MRR--P- ------------------------------------------------------------------------ ------------------------------------------------------------IDDYEEKFDDKK -----------------------KPKDGKIALSVHAHRVSNVG----------------------------- ---------------------------------------------------------NNIRNATIDDTIQKM Y-----------------------------------------------------YSPPVVKAFE-NICFIAE LLKKKDRDD-KIDEDWKYVAMVLDRLFLLIFSIACFVGTVIILLRAPTLYDTRQPIDLQYRPANLSANPISF ------------------------------------- >Fruitfly_3R_2/1-576 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------MAPGCCTTRPRPIALLAHIW RHCKPLCLLLVLLLLCETVQANP---------DAK-RLYDDLL-----SNYNRLIRP-VSNNTD-TVLVKLG LRLSQLIDLNLKDQILTTNVWLEHEWQDHKFKWDP----SEYGGVTE-LYVP--SE---HIWLPDIVLYN-- -NAD-GEY-VVTTMTKAILHYTGKVVWTPPAIFKSSCEIDVRYFPFDQQTCFMKFGSWTYDGDQIDLKH--- ---------------ISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAERHEKY-Y-PCCAEP-------YP D----IFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPA-DS-GEKIALCISILLSQTMFFLLISEIIP STSLALPLLGKYLLFTMLLVGLSVVITIIILNIHYRKPST-HK-MRPWIRSFFIKRLPKLLL---MRV--P- --------------------------------------------------------------------KDLL RDLAANKINYGLKFSKTKFGQ------------------------------------ALMDEMQMNSGGSSP DSLRRMQGRVGAGGCNGMHVTTATNRFSGLVGALGGGLSTLSGYNGLPSV---------------------- ---------------------------------------------------------LSGLDDSLSDVAARK K-----------------------------------------------------YPFELEKAIH-NVMFIQH HMQRQDEFN-AEDQDWGFVAMVMDRLFLWLFMIASLVGTFVILGEAPSLYDDTKAIDVQLSDVAKQIYNLTE KKN---------------------------------- >Fruitfly_3R_3/1-519 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MWHWS LLCVFLLVPLANSTAPISFEANP---------DTK-RLYDDLL-----SNYNRLIRP-VVNNTE-TLTVWLG LKLSQLIEVNLKNQVMTTNLWVKQRWFDYKLRWDP----EEYGGVEQ-LYVP--SE---HIWVPDIVLYN-- -NWD-GNY-EVTLMTKATLKYTGEVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKH--- ----------------LDQIPGSNLVQVGIDLTEFYLSVEWDILEVPATKNEEY-Y-PDTLEP-------FS D----ITFKLTMRRKTLFYTVNLIVPCVALTFLTVLVFYLPS-DS-GEKVTLCISILVSLTVFFLLLAEIIP PTSLAVPLLGKYLLFTMILVSLSVWTTVCVLNIHFRSPST-HN-MSPLVRKLFLHFMPKLMM---MRR---- ------------------------------------------------------------------------ -------------TQYTLPDY-----------------------------------------DDSTPSNGYT ------------------NEIDVRDSISDFPSEFKDSQDGAYD----------------------------- ---------------------------------------------------------NGMQNSVDSDNVIPR N-----------------------------------------------------LTPEVLQALR-AVRFIAQ HIKDADKDN-EIVEDWKFVSMVLDRFFLWLFTLSCVFGTLAIICQSPSLYDTRSPIDRQLSEIPLRKNNFML PPDIVRQVLT--------------------------- >Fruitfly_3R_1/1-597 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MGSVLFAAVFIALHFATGGLANP---------DAK-RLYDDLL-----SNYNRLIRP-VGNNSD-RLTVKMG LRLSQLIDVNLKNQIMTTNVWVEQEWNDYKLKWNP----DDYGGVDT-LHVP--SE---HIWLPDIVLYN-- -NAD-GNY-EVTIMTKAILHHTGKVVWKPPAIYKSFCEIDVEYFPFDEQTCFMKFGSWTYDGYMVDLRH--- ----------------LKQTADSDNIEVGIDLQDYYISVEWDIMRVPAVRNEKF-Y-SCCEEP-------YL D----IVFNLTLRRKTLFYTVNLIIPCVGISFLSVLVFYLPS-DS-GEKISLCISILLSLTVFFLLLAEIIP PTSLTVPLLGKYLLFTMMLVTLSVVVTIAVLNVNFRSPVT-HR-MAPWVQRLFIQILPKLLC---IER--P- -----------------------------------------------------------------------K KEEPEEDQPPEVLTDVYHLPP---------------------------------DVDKFVNYDSKRFSGDYG IPALPASHRFDLAAAGGISAHCFAEPPLPSSLPLPGADDDLFSPSGLNGDISPGCCPA-------------- ---------------------------------------------------------AAAAAAADLSPTFEK P-----------------------------------------------------YAREMEKTIE-GSRFIAQ HVKNKDKFE-SVEEDWKYVAMVLDRMFLWIFAIACVVGTALIILQAPSLYDQSQPIDILYSKIAKKKFELLK MGSENTLXRPLGFAAGWWNLIISSLRTLFAARDDDRG >Fruitfly_X_1/1-795 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M KWFQVTIDMILVLSFISSSTANP---------DAK-RLYDDLL-----SNYNKLVRP-VVNVTD-ALTVRIK LKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLKWEP----KEYGGVEM-LHVP--SD---HIWRPDIVLYN-- -NAD-GNF-EVTLATKATLNYTGRVEWRPPAIYKSSCEIDVEYFPFDEQTCVMKFGSWTYDGFQVDLRH--- ----------------IDELNGTNVVEVGVDLSEFYTSVEWDILEVPAVRNEKF-Y-TCCDEP-------YL D----ITFNITMRRKTLFYTVNLIIPCMGISFLTILVFYLPS-DS-GEKVSLSISILLSLTVFFLLLAEIIP PTSLVVPLLGKFVLFTMILDTFSICVTVLVLNIHFRSPQT-HT-MAPWVRTVFINQLPRFLV---MRR--PL YPISEMIKSSRRLMVRTCNGLELRDQIPPLPPPVALSRMHHSPKTTSRSTSPHLQHRVQTYNLMDECGMGMG GGASTITGHLSSLYPPTMSTANQQTSTTSSLIDAQYHNQYQQTGGSLLDHPLTPTKFRQMTSTSSQTGQNGS GNGNGNGGYGGHGQSGGHHLYRQQSSCSANFSPLPQHAHQAHASTTTSDLGMANPNVIKSTTTVNSVATAST LADSCCSGTIQIHQGMGAGAACQSSELLHHQQLHHQQMHHQQQQQQQQQHHHHQRPTTSAAAAAAAAAAGGP STSAAAAAAAAAAAAGTPPPPPPPAGVCDILPACQREGGPHCCSGRGNVRQRWHTCPELHKAMD-GVTYIAD QTRKEEEST-RVKEDWKYVAMVLDRLFLWIFTIAVVVGTAGIILQAPTLYDTRMPIDIKLSEIASTTAKPNV ARPVL-------------------------------- >Fruitfly_3L_2/1-539 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------MVHGAVAGNP---------DAK-RLYDDLL-----SNYNKLVRP-VVNTTD-VLKVCIK LKLSQLIDVNLKNQIMTTNLWVEQSWYDYKLRWEP----KEYGGVHM-LHVP--SD---HIWRPDIVLYN-- -NAD-GNF-EVTLATKATIYSEGLVEWKPPAIYKSSCEIDVEYFPFDEQTCVLKFGSWTYDGFKVDLRH--- ----------------MDEQQGSNVVAVGVDLSEFYMSVEWDILEVPAVRNEKF-Y-TCCDEP-------YL D----ITFNITMRRKTLFYTVNIIIPCMGISFLTVLTFYLPS-DS-GEKVTLSISILISLHVFFLLVVEIIP PTSLVVPLLGKYLIFAMILVSISICVTVVVLNVHFRSPQT-HK-MAPWVKRVFIDFLPAFLF---IKR--P- -------------------------------------------------------------------TYNFE TSKLLLKDTHACFYPYYSATN-----------------------------------------IDRLVSSGYN NSLPKEDLSQSITANGPFGGSCQVHGPVPPLTHCSSDEIAAVPDMDIGPL---------------------- ---------------------------------------------------------GMKSPILNNPAFSHS K-----------------------------------------------------CLPKIHKSCF-CVRFIAE HTKMQEDST-KVKEDWKYVAMVLDRLFLWIFTLAVVVGTAGIILQAPTLYDDRIPIIEQKDLDFSGTSAGRC RPPQ--------------------------------- >Amphioxus_scaffoldNW003101367_1/1-440 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------MRDLF-----ADYSSFPRP-VSNTTH-IVSVKFG LSLSQIVGLNMKDQVMTTSVWLKQIWEDYKLTWDP----AEYDGITR-IKVP--VD---MIWIPDVLLYN-- -NAD-GKF-EVSSFTKATLFYNGTVVWTPAGIYKSYCYIDVTFFPFDRQNCSMKFGTWTYDATVVDMVP--- -------------------------IEPVVDLSNFLANGEFVIMSAPLYRHVLS-Y-ECCPP--------YV D----ITAYIVLERLPLYFTVNLLIPCLLFTFLSLLVFYLPS-KA-CEKITLCISILLSLAVFLLVVVKIIP STSLAVPLLGKYLLLTTVCVILSVVVTTVVLHLSDRTD----P-MPGWARKMLLQVLPRLLC---MTR--P- ------------------------------------------------------------------------ --------------------------------------------------------------GSNKVAEMLL ----------------------NSQADVLDDLPEGETVYASIRPRG-------------------------- ---------------------------------------------------------SPRLTRNLQLHREEH P-----------------------------------------------------ISPELRATVK-NINAIAK SLRGDMLNS-SLSDDWQYAGLVLDRFFMWVFFLISLIGSLVIFL--PPFVFDRSVVISY------------- ------------------------------------- >Amphioxus_scaffoldNW003101367_2/1-414 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------MSDLF-----DVYHKFPRP-VKNITD-KVTVNFG ISLSQLIDMDEKNQVLTTSVWLKQRWDDYKLTWNP----DEYDGVKY-LKVP--SD---MIWVPDVLLYN-- -NAD-GRF-DVSSYTWAKVFFNGTVEWIPAGIYKSYCYIDVTNFPFDRQTCKMKFGTWTYDFTLIDMKP--- -------------------------LDEQIDLSNFRESGEFTVVDTPLVRSVVE-Y-ACCPP--------YV D----ITAYIVIDRLPLFFTVNLVIPCLIFTFLAILVFYLPV-DA-GEKVGLAITILLSLSVFLLVIFTIIP ATSFAIPLLAKYLLFTNVVCTISVIITCVVLHLHHRTDE-----MPRWGKRVFLHILPKLLR---MGR--P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------DDGEADSRGGVPD S-----------------------------------------------------LMAELDPAVK-GVEYIAE HVKGEIEGG-QVADDWKYAAMVVDRISMYMFIILCGIGVLATFL--PPFVYGPPEPEIPPSQVGGPPTA--- ------------------------------------- >Amphioxus_scaffoldNW003101420_9/1-438 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------SD----------SEH-RLINHLF----DSGYNKVIRP-VQSRGE-VVNVNLQ IVFSQLIAVEEREQMMKTNLWLGQDWYDYRLSWNP----EDFDNIDM-VRVS--SE---DIWRPDVVLFN-- -NAD-GNY-DIQLMTKAWVQSDGHVHWAPPVVYASACFIVVKYFPFDRQNCTMKFGSWTYDADELDLTL--- -------------------------LDGEAQMHRYKQNGEWDILRSPNRK-----Y--------------YA DKRVYVNFDFIIKRKPLFYTINLIIPCILITSLSVLVFYLPA-DE-GEKVTLGITVLLALIVFLLLIADIIP PTSLDVPLIGKYLLFTMIFVSVAIVATVYVLNVHHRTSST-HD-MPDWIKAVFLEKLPKLLR---MER--P- ------------------------------------------------------------------------ -----------DTLARTCIHE-----------------------------------------HTHMRSDLRI ------------------------KVCNNTAFRY-------------------------------------- ---------------------------------------------------------TRHTLGSIKAVYNCP C-----------------------------------------------------FCRSARKALK-NLKLISE YFRNQDEDD-GVAGDWQYVAMVIDRICLWLFATVCFLGTLGLFL--QPFVGSDEE----------------- ------------------------------------- >Amphioxus_scaffoldNW003101420_3/1-333 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------LSPRGAFCAA---------SEE-NLVRQLF---NESRYSPDVRP-VVAPTD-VLPVNFK LLVIQVIAVNEKAEFMRTNVWVELSWVDYRLAWNK----EDFDHIPS-IRVP--AE---SVWKPDIVLLN-- -NKD-GQY-DVALHTKAIISNDGSVYWLPPSIFTSECSINVRHFPFDKQNCTLQFSSWTYSKREVDLVN--- ---------------------------LGFVYDDFKQSGEWQIVDIPSRRVEIE------DSV-------F- -----VIYDFMLARKPLFYIVNMIVPIILLTLLSILVFYLPV-DC-GEKVGLCINILLALVVFVLLIADIIP ATSLDIPLIGRYLMFTMIFVTIETVTTIYVSNIHFRGAST-HV-MSPWIRYIFLKLLPRLMK---VPPPGEE ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------- >Amphioxus_scaffoldNW003101420_4/1-456 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MDRLGGITLLILVITITGTLAAD---------SEE-RLVRMLF---NESAYNPGVRP-ALTPAE-VVSVKIT LAVSQVISVIEKEEVMRTNVWVAQEWTDPRLSWNK----EDYDHISL-IRVP--AE---AIWRPDIMLFN-- -NKD-GQY-DVALYTRALVYDSGYVYWLPPAIFTSECSINVRHFPFDKQNCTLQFGSWTYDKREVDLQQ--- ---------------------------GGYVQDDFKESGEWAILEIPDRKVETD------DNV-------F- -----IAYDFMLARKPLFYIVNMIVPIILLTLLSIFVFYLPV-DC-GEKVGLCINILLALVVFLLLIADIIP STSLDIPLIGRYLMFTMIFVTIVTVMTIYVGNVHFRSTAT-HV-MSPWIRYIFLELLPKLMK---MSP--P- ------------------------------------------------------------------------ --------------------------------------------------------------GEEEEEEEED -----------------------EDSSPTWDAVEMRKRDGV------------------------------- ---------------------------------------------------------VQNGRPPVPPRSDQP K-----------------------------------------------------LSSELREAAG-NVQLISD HFKDQDDDS-AVSDEWRFMAALVDRICLWLFSIILLVGTVVLFA--EPWYEDSFQ----------------- ------------------------------------- >Amphioxus_scaffoldNW003101420_5/1-490 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MDGWIPALFLLTAVYTAGCECAE---------AEE-RLVRHLF---NSTNYSPLIRP-ALRPGD-IVTTTFS LYLSQLISVTEKAEILKTNVWLEQQWQDYRLAWVK----EDFDHLEA-IRVP--AA---VVWKPDIVLFN-- -NKD-GQF-DVALHSNVIVYNTGDCYWLPPAIFQSSCSIDVRQFPFDRQNCSMKFGSWTYTSDEVNLVI--- -----------------------SDYGKTAILDDFKASGEWNLLDSPSRRLVEG------DEV-------Y- -----IYYDLIIERKPLFYIINLIIPCIAISSLSVLVFYLPS-DC-GEKITLSISVLLAMTVFLLLIADIIP STSLQIPLIGKYLMFTMIFVTMTTVSTVCILNMHHRTDKT-HE-MPAWMRAV-TRVLATILR---IQK--P- -----------------------------------------------------------------------G DDEEDEEEKPIYMWDQPVDSM-----------------------------------------PMKKVISSLL -----------------FTIDINVTVRNGVLQDAQGRPLGTISQ---------------------------- ---------------------------------------------------------GSPQAPPRQDRNSPV V-----------------------------------------------------LPPEMQDAVK-SVKFIAD HFKTKDEGA-AVSDEWSFVALVIDRVCLWLFIIVCVLGTLGLFF--EPLFLGNTG----------------- ------------------------------------- >Amphioxus_scaffoldNW003101420_1/1-464 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MLVTKVNVSFCRSHTETLAAE---------AEE-RLVQRLF---NESRYNPLIRP-ARYNGE-KVLVHFR LSISQLINVDEKNQKMKTNVWLHQEWFDYRLSWDP----REYDNIKV-IRVP--SE---IVWRPEIVLFN-- -NAN-GQY-DVQLMPKCLIYSGGNITWIPPAIYESACQIDVRFFPFDQQNCSMKFASWTYDGTELDLEL--- -------------------------KDTNAVMDDFKKNGEWDILRLPGRKSSHA------GDP-------LP Y----VYFDFILMRRPLFYTINLIIPCILITSLSVLVFYLPS-DC-GEKITLSISVLLALTVFLLLIADIIP PTSLDVPLIGKYIMFTMIFVTFTIVTTVYILNVHHRHPST-HT-MPPWVRTVFLDKLPRLLL---MKR--P- ------------------------------------------------------------------------ --------NQCRKYALRVSES-----------------------------------------SARNPHEDFP ------------------------EDHTDSPYYSPRTRPA-------------------------------- ---------------------------------------------------------HTHYKQIDLPPEVPS D-----------------------------------------------------LPPELKKAVK-NVRYIAD YFRSHDQDL-SISEDWKYVAMVIDRIFLWTFVSVCFIGTLGLFL--QPLL---------------------- ------------------------------------- >Amphioxus_scaffoldNW003101420_10/1-469 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------MSFPLAGRAAE----------SEE-RLVAMLF---NTSRYNPLIRP-ARTVNE-VITVNFR LSISQLISVNEKDQVMKTNVWLNQDWIDYRLVWNP----EDYDNIEI-IRVP--SE---ITWKPDLVLFN-- -NAD-GQY-DVQLKTKALIANTGQVYWLPPAIYQSACSIEVRYFPFDRQNCTMKFGSWTYDSSEVNIEL--- -------------------------IDHEVVMDDFKQNGEWDILRSPNRKVVSG------SEM-------F- -----VMFDFIIQRKPLFYTINLIIPCILITSLSVLVFYLPS-DC-GEKITLSISVLLALTVFLLLIADIIP PTSLDIPLIGKYLMFTMIFVTFTIVTTVYILNVHHRSAST-HT-MPPWVRTLFLDKLPKLLF---MKR---- ------------------------------------------------------------------------ ---LDQMNDEDGDSDKGCKHL----------------------------------------KAFGRDPVDVV ----------------------HMKQRNAMLYETQCRKYALKV----------------------------- ---------------------------------------------------------SDVSGSQTLSENISL Q-----------------------------------------------------LSPEMRRAVS-NVKFIAE YFKMQDAND-AVNEDWKYVAMVIDRICLWLFLSVCVIGTLGLFL--QPLFISDDDIV--------------- ------------------------------------- >Amphioxus_scaffoldNW003101420_8/1-457 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------LSAE---------SEE-RLVTRLF---NSSRYNPMIRP-AQFPTE-IVTVKFY LIISQLISVNEKEEVMKTNVWLAQTWTDYRLMWNK----EDYDHVQV-IRVP--SE---SVWKPDIVLFN-- -NKD-GQY-DVALYTKVLIYDDGKVEWLPPAIYQSSCAIDVRHFPFDKQNCTMKFGSWTYNGDEVDIVL--- -------------------------DSEEAVSDDFKLNGEWDIIKSPSRRTLEG------DEV-------Y- -----VHYDFVIKRKPLFYIINLIIPCILISSLSVLVFYLPS-DC-GEKITLSISVLLALTVFLLLIADIIP STSLDIPLIGRYLMFTMIFVTFTTVTTVYILNVHHRTAST-HD-MPTWIRIVFINVLPRILC---IKR--P- ------------------------------------------------------------------------ -----ADEEVVDVKETVIRTS-----------------------------------------LYHKPREDAM -----------------------EMRKRNGMMTEGGRGFGTVP----------------------------- ---------------------------------------------------------RSSSPGPGLQQTERR H-----------------------------------------------------LAPELEDAVK-HVKYIAG FFKSQDDDS-EVSDEWRFVAMVIDRICLWLFLLVCVVGTLGLFK--EPLFDGDDV----------------- ------------------------------------- >Amphioxus_scaffoldNW003101420_6/1-448 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------IRSGVYGAT---------SEE-NLVRMIF---EERGYNPTIRP-AKSPDE-VITVHFY LSISQLISLNEKEETMKTNVWLGQSWYDHRLAWNS----AEYDNLTV-IRVP--AE---AVWNPNIVLFN-- -NKD-GQY-EVALYTKVLVYEDGKVEWLPPAIFQSNCAIDVRQFPFDRQNCSMKFGSWTYSPEELDIVL--- -------------------------DYDTATTDDFKESGEWNILKSPCRKVANE---------------KEV S----VFFDFIIQRKPLFYIINLIIPCILTSSLSILVFYLPS-DC-GEKIGLNMAVLLAMTVFLLLIADIIP STSLDVPLIGKYLIFTMTFVTMTTVATVMILNVHHRTAST-HE-MPGWIRFVFIRVLPRILR---LHQ--P- ------------------------------------------------------------------------ --------------------------------------------------------------GEDGEGAEEH --------------------SNTWDPDIDMPFGRIG------------------------------------ ---------------------------------------------------------TGLPGGNSKEERAAG K-----------------------------------------------------MPPDLTRVIR-NVKAVAC FFKDQDEES-QINDEWKFVAIVIDRLCLWLFLIICVLSTLGLFY--EPLFLPDDIDVSSVP----------- ------------------------------------- >Amphioxus_scaffoldNW003101420_7/1-437 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------MTGAHGAE---------SEE-RLVRMLF---DERGYNPMTRP-SRWLGD-VTRVNFS LTISQLISLTEKEEAMKTNVWLGQSWFDHRLAWDS----KLFGGQSI-IRAP--AE---AVWKPDIVLFN-- -NKD-GQY-DVALFTKVLISSNGQVDWLPPAIFKSGCAIDVIQFPFDRQNCSMNFGSWTYDSQEVDVRL--- -------------------------VVDRATMDDFKPSGEWDILDSPGRRVVTG---NQVR----------- -----VIFDFIIQRKPLFYIINLIIPCILTSSLSILVFYLPS-DC-GEKIGLNMAVLLAMTVFLLLIADIIP STSLAVPLIGKYLIFTMIFVTMTTVATTMVLNVHHRTAST-HE-MPGWIRFVFIDVLPGILR---MEK---- ------------------------------------------------------------------------ -------------EEEEATPS-----------------------------------------EKLQNGAPYF --------------------------SSDQVID--------------------------------------- ---------------------------------------------------------SAGSDAPREDRGSSR R-----------------------------------------------------LGPEIGKAVK-NLKTIAD FFKSTDEDS-EVNDEWQFVAQVIDKLCLYLFLAVCVLVTVGLFF--QPMFLSG------------------- ------------------------------------- >C.elegans_I_3/1-502 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------MG PNDHGFAYILIFLLLSPPTHANR---------DAN-RLFEDLI-----ADYNKLVRP-VSENGE-TLVVTFK LKLSQLLDVHEKNQIMTTNVWLQHSWMDYKLRWDP----VEYGGVEV-LYVP--SD---TIWLPDVVLYN-- -NAD-GNY-QVTIMTKAKLTYNGTVEWAPPAIYKSMCQIDVEFFPFDRQQCEMKFGSWTYGGLEVDLQH--R DKHLEKEIEEDVEGVDGPTKEIVWVVDRGIDLSDYYPSVEWDILNVPGKRHSKR-Y-PCCESP-------FI D----ITYEIHLRRKTLFYTVNLIFPSVGISFLTALVFYLPS-DG-GEKISLCISILISLTVFFLLLVEIIP STSLVIPLIGKYLLFTMVLVTLSVVVTVVTLNVHYRSPTT-HT-MPKWMKRLFVDFLPKYLL---MTR--P- ------------------------------------------------------------------------ ------------------QPP-----------------------------------------GHHSKPNRKF ------------------------DSRASTFSIGVNHVLGQNSELLS------------------------- ---------------------------------------------------------PGLNSNREESSFTLP R-----------------------------------------------------DNSPVRSAVE-SVAYIAD HLKNEEDDK-QVIEDWKYISVVMDRIFLITFTFACAFGTVVIIA-RAPSIYDNTPALA-------------- ------------------------------------- >CionaSavignyi_reftig385/1-482 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------ECTSAH---------AEE-ELLRHLL---DSGRYNKLIRP---------SQSNFD LIISQLIGINEREQFMITKVWLPQVWVDERLSWQP----TEYENITK-VQLP--SD---MIWLPDIVLYN-- -NAD-GTY-EVSLQSNAIILNNGTVTWMPPAIYKSACKIKVRHFPFDEQNCTMMFRSWTYDRDDIELKL--- -------------------------MNPNATLDDFTPSGEWDILATPGMMNLNA------DDP------SYQ D----LLYSLVIRRKPLFYTVNLIIPCILITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLIGKYLMFTMMLVTFSIIASVCVLNIHHRSPST-HE-MSPWIRRTFLQVIPPLIG---MQR--P- ------------------------------------------------------------------------ -GTDQCSYNKYKVDVSDLSGS-----------------------------------------DVIRKRKQPE VQLSRDISSALEGVKLISDHLKAEDRNKNVSFIGYLYILEYLIFRLT------------------------- ---------------------------------------------------------RMLIRGYISFIVLLD S-----------------------------------------------------PTPAVHVQFR-SQGWIRQ HLFNLSSCELVIHEDWKYVAMVIDRMFLFVFVVVCAVGTVSIFL--QPFV---------------------- ------------------------------------- >CionaIntestinalis_scaffoldHT000135/1-451 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MGSRCWLIAVCLCYVIRECLSAH---------AEE-KLLRHLL---DPVRYNKLIRP-SESITS-KVDVHFD LIISQLIGINEREQYMITKVWLPQVWVDKRLSWQP----MRYENITK-VQLP--SN---MIWLPDVVLYN-- -NAD-GMY-EVSLQSNAIILNNGTVTWMPPAIYKSACKIKVRHFPFDEQNCTMMFRSWTYNRLDIELKL--- -------------------------KNPNATLDDFTPSGEWDILQTPGSVNVNP-----NDET-------YQ D----LLYSLIIRRKPLFYTINLIIPCILITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLIGKYLMFTMMLVTLSIVASVCVLNIHHRSPST-HT-MPPWIRTIFLNHLPPLLG---MER--P- ------------------------------------------------------------------------ --------------------------------------------------------------GTDDRCRCKV ---------------------------NDATYGVDVTELS-------------------------------- ---------------------------------------------------------GSDVIRNRKRGKSEV K-----------------------------------------------------LPRDVSSALE-GVKFIAD HLRAEDENK-NVHEDWKYVAMVIDRMFLFVFVGVCAIGTIGIFI--QPFV---------------------- ------------------------------------- >AustralianGostshark_scaffoldNW006890058_3/1-493 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------MKPPAKDDSGKRS ATEMDVVLLLCFLTIIKSGGGAE---------TEE-KLMKYLL---NEERYNRLIRP-AINNSE-IVKIVLQ VSLAQLINVNEREQIMTTNVWLKQEWFDYRLSWDP----ADYDGICK-VRVH--SK---LIWLPDVVLYN-- -NAD-GTY-EVSVYTNVIITYNGSIYWLPPAIYKSSCKIEVKHFPFDQQNCTLKFRSWTYDYTEIDLVL--- -------------------------KTDTASIDDFTPSGEWDIISLPGRRNVNP-----FDAT-------YV D----VTYDFIIKRKPLFYTINLLIPCMLITLLAVLVFYLPS-DC-GEKITLCISVLLALTVFLLLIAKIVP PTSFDVPLIGKYLMFAMVLVTFSIVTSVGVLNVHHRSPST-HD-MPPWVKTVFLEKLPALLF---IKR--P- ------------------------------------------------------------------------ -----QNSSLEQRLHQSQNSS-----------------------------------------AAVSLEDRYN ---------------------------TLFVNPASTRNCDLSVLDSP------------------------- ---------------------------------------------------------EGFACHRDLRLRNSM K-----------------------------------------------------YSPEVQQAID-GVKFIAD NMKNEDENE-SVTEDWKYVAMVVDRLFLWIFVVVCVVGTIGLFL--QPIVYNHPYP---------------- ------------------------------------- >SpottedGar_LG3_2/1-513 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------MGLRLRGIDFMAP TMKRTLALCVCFLTLIKKCSSAD---------AEE-RLMNCLL---GKDRYNKLIRP-AVNSSE-RVTITLQ VSLAQLISVNEREQIMTTNVWLNQLWVDYRLSWDP----SEYDGIDK-LRIP--AR---HLWLPDIVLYN-- -NAD-GTY-EVSLFTNAIVQFNGSIFWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDYTEIDLVL--- -------------------------KNNVASMDDFTPSGEWDIVALPGRRIVNP------LDP------TYV D----VTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLIGKYLMFTMVLVTFSIITSVCVLNIHHRSPST-HT-MPPWVKVVFLDKLPALLF---MKR--P- ------------------------------------------------------------------------ -HNNSARQRLRQQQLRACKAA-----------------------------------------LGCAPPSAFL --------------------SSSSASSPRHFYKNAASFINSVRKSELRIPDVH------------------- ---------------------------------------------------------SSFPAPQDFRQQSSG Y-----------------------------------------------------FRPDVQEAIN-GVRFVAD HMRCDDDDQ-SVIEDWKYVAMVVDRMFLWIFVFVCVVGTLGLFL--QPLFQNQNVVSHY------------- ------------------------------------- >Zebrafish_18_2_chrnb4/1-525 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------MGLKRCRIPAGS SMTRALCVLLCALSLARSGVCAD---------SEE-RLMNWLL---GKHRYNKLIRP-ALNRTE-RVTVLLQ VSLAQLISVNEREQIMTTNVWLTQNWNDYRLSWDP----AEYEGIDK-LRIP--SR---HIWLPDIVLYN-- -NAD-GTY-EVTVFTNAIVLFNGSIAWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDLLL--- -------------------------KSDAASMDDFTPSGEWDILALPGRRTVSP-----LDAT-------YV D----LTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLIGKYLMFTMVLVTFSIITSVCVLNVHHRSPST-HS-MPAWVKIVFLVRLPALLF---MQR--P- ------------------------------------------------------------------------ -----RGHSARQRLRQNRRLL-----------------------------------------GLADTPGRSV ----------MCSSASALLAASSASALSSPGLLYNKGHFGSRRAEGLNN----------------------- ---------------------------------------------------------GHGSAQDLKGNRLYC E-----------------------------------------------------WGSEIQEAVD-GVRYVAD HMMGNDDDQ-SVIEDWKYVAMVVDRLFLWIFVIVCVVGTLGLFL--QPLFQNQTLAIQQPNTEPARRDGM-- ------------------------------------- >Medaka_3_2/1-547 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------MFGWKRRSSGSAPGNPRGADAAVR MSWAPLLILTYFSALMQSCKSAD---------SEE-RLMNMLL---GKHRYNPLIRP-AINRTE-RVEVKLQ VSLAQLISVNEREQIMTTNVWITQHWVDYRLSWDP----AKYEGIQK-LRIP--SR---HVWLPDIVLYN-- -NAD-GIY-EVTVFTNVIVLFNGSVNWLPPAIYKSACKIEVKHFPFDLQNCTLKFRSWTYDHTEIDLIL--- -------------------------KSEAASMDDFTPSGEWDIIALPGRRTVNP------TDP------TYV D----LTYDFIIKRKPLFYTINLIIPCILITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLIGKYLMFTMVLVTFSIITSVCVLNVHHRSPST-HT-MPSWVKLIFLKKLPALLF---MKR--P- ------------------------------------------------------------------------ ----NNFSGCQRLRQQRCLRA-----------------------------------------RRSILGLDYP ---------NASKACFTLSSSALLPSDSAFSTPRHKNLAPTMGYGLSRRKGDLSSSDYPH------------ ---------------------------------------------------------ISLTPTQDYQQKCKS D-----------------------------------------------------WTADVKEAVK-GVRFVAE HMMADDDDQ-SVIEDWKYVAMVVDRMFLWIFVIVCVVGTLGLFL--QPLFQSQMITSQQPSSDKPRI----- ------------------------------------- >Fugu_13_3/1-518 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MGRTLCIVAYFLSVVHCCRCAD---------SEE-RLMNWLL---GKNRYNPLIRP-ASNRTE-RVPVKLQ VSLAQLISVNEREQIMTTNLWLMQHWVDYRLSWDP----AKYEGINK-LRIP--SR---LIWLPDIVLYN-- -NAD-GTY-EVTVFTNAIVLFNGSINWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDRTEIDLVL--- -------------------------KTDAASMDDFTPSGEWDILALPGRRTVNP------LDP------TYV D----LTYDFIIKRKPLFYTINLIIPCILITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLIGKYLMFTMVLVTFSIITSVCVLNVHHRSPST-HT-MPSWVKLIFLVKLPSLLF---IRR--P- ------------------------------------------------------------------------ --------QNNSARQRLQSQR-----------------------------------------CQRAKRDILG LGCQPKSSITMLSSALLSPGSVFSTPGQKNVAPSLSCGYGKGDLRPTTYLP--------------------- ---------------------------------------------------------GGLNITQNLQQSSGA D-----------------------------------------------------WAADVQEALS-GVRFVAE HMMEDDDDQ-SVIEDWKYVAMVVDRMFLWIFVIVCVVGTLGLFL--QPVFQNPITPIQQPSSDMPRI----- ------------------------------------- >Stickleback_II_1/1-467 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------SRCAE---------SEE-RLMNWLL---GKDRYNLLIRP-AVNRTE-RVPVKLQ VSLAQLISVNEREQIMTTNVWLTQHWVDYRLSWDP----AKYEGIDK-LRIP--SR---HIWLPDIVLYN-- -NAD-GTY-EVTVFTNAIVIFNGSINWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDLIL--- -------------------------KSEVASMDDFTPSGEWDILALPGRRTVNP------LDP------TYV D----LTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLIGKYLMFTMVLVTFSIITSVCVLNVHHRSPST-HT-MPSWVKLIFLVKLPALLF---MRR--P- ------------------------------------------------------------------------ ----QNNSASQRLRRQRCLRA-----------------------------------------RKSIGSSGYP ------------------------DAAKTGFILSPSALKGDLRST--------------------------- ---------------------------------------------------------DYIPSGQDLKQSTSS D-----------------------------------------------------WAADVQEAVN-GVRFVAE HMMGDDDDQ-SVIEDWKYVAMVVDRMFLWIFVIVCVVGTLGLFL--QPVFQTQIVPNQQ------------- ------------------------------------- >WesternClawedFrog_3_2/1-481 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M RNLSSLLLLLTALLWVNCCKAAD---------SEE-RLMNNLL---RKDKYNKLIRP-AYNNSQ-LVSIQLQ LSLAQLISVNEREQIMTTNVWLNQEWVDYRLTWNP----ADYDGIKK-LRIP--SQ---QIWLPDIVLYN-- -NAD-GTY-EVSLFTNAIVQNNGSVAWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDYTEIDLVL--- -------------------------NKGWATMDDFTPSGEWDIIELPGRRT------ICPLDP------TYV D----VTYDFIIKRKPLFYTINLIIPCILITSLAILVFYLPS-DC-GQKMTLCISVLLALTVFLLLISKIVP PTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPST-HT-MPPWVKNCFLDRLPVFLF---MKR--P- ------------------------------------------------------------------------ -----------------------------------------------------------ENSSASQKLRSYR ------------------RNMQIESFRNSNYFVNMTTARPCDHTVNDP------------------------ ---------------------------------------------------------PESVRHQEFRYRYPR K-----------------------------------------------------YTPEVHEAMD-GVKFISE HMKSEDEDQ-SIIEDWKYVAMVVDRLFLWIFIIVCIVGTVGLFM--QPLIQNHTPPDDH------------- ------------------------------------- >Mouse_9_3/1-495 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M RGTPLLLVSLFALLQPGDCRLAN---------AEE-KLMDDLL---NKTRYNNLIRP-ATSSSQ-LISIRLE LSLSQLISVNEREQIMTTSIWLKQEWTDYRLAWNS----SCYEGVNI-LRIP--AK---RVWLPDIVLYN-- -NAD-GTY-EVSVYTNVIVRSNGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVL--- -------------------------KSPTAIMDDFTPSGEWDIVALPGRRTVNP------QDP------SYV D----VTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-GEKMTLCISVLLALTFFLLLISKIVP PTSLDIPLIGKYLLFTMVLVTFSIVTTVCVLNVHHRSPST-HT-MASWVKECFLHKLPTFLF---MKR--P- -----------------------------------------------------------------------G LEVSPARVPHSSQLHLTTAEA-----------------------------------------TSTSALGPSS ----------------------PSNLYGNSMYFVNPVPATPKSAVSS------------------------- ---------------------------------------------------------HTAGLPRDARLRSSG R-----------------------------------------------------FRQDLQEALE-GVSFIAQ HLESDDRDQ-SVIEDWKFVAMVVDRLFLWVFVIVCILGTMGLFL--PPLFQIHAPSKGL------------- ------------------------------------- >Human_15_4_CHRNB4/1-498 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------MR RAPSLVLFFLVALCGRGNCRVAN---------AEE-KLMDDLL---NKTRYNNLIRP-ATSSSQ-LISIKLQ LSLAQLISVNEREQIMTTNVWLKQEWTDYRLTWNS----SRYEGVNI-LRIP--AK---RIWLPDIVLYN-- -NAD-GTY-EVSVYTNLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVL--- -------------------------MTPTASMDDFTPSGEWDIVALPGRRTVNP------QDP------SYV D----VTYDFIIKRKPLFYTINLIIPCVLTTLLAILVFYLPS-DC-GEKMTLCISVLLALTFFLLLISKIVP PTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPST-HT-MAPWVKRCFLHKLPTFLF---MKR--P- ------------------------------------------------------------------------ ---GPDSSPARAFPPSKSCVT------------------------------------KPEATATSTSPSNFY --------------------------GNSMYFVNPASAASKSPAGS-------------------------- ---------------------------------------------------------TPVAIPRDFWLRSSG R-----------------------------------------------------FRQDVQEALE-GVSFIAQ HMKNDDEDQ-SVVEDWKYVAMVVDRLFLWVFMFVCVLGTVGLFL--PPLFQTHAASEGPYAAQRD------- ------------------------------------- >Opossum_1_1/1-504 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------MRKAPTLLFLLLLLLAMVSIFC NQRNSGSAKARLWNETGNCRMAN---------AEE-KLMNFLL---NKTRYNNLIRP-AANSSQ-LVSISLQ VILAQLISVNEREQIMTTNIWLKQEWTDYRLAWNS----SQYEGVNI-LRIP--SK---RIWLPDIVLYN-- -NAD-GTY-EVSVYTNAVVSSNGSIFWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVL--- -------------------------KTPTASMDDFTPSGEWDIIELPGRRTVNP------LDP------SYV D----VTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPST-HT-MAPWVKVLFLERLPTFLF---MKR--P- ------------------------------------------------------------------------ --VNNPTRSQIDQRRRNKSES-----------------------------------------LHNASTGNLY --------------------------KNSMYFVNPTSAPRAAGGT--------------------------- ---------------------------------------------------------DSSGGQKDLRLRSFK R-----------------------------------------------------YQPEVQEAID-GVSFIAD HMKSDDSDQ-CVIEDWKYVAMVVDRLFLWIFICVCVLGTAGLFL--PPLFQNYSPP---------------- ------------------------------------- >Chicken_10_1/1-489 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M RNTYTLFLFVVGSFYFNGSTAAD---------AEE-KLMNHLL---SPDRYNKLIRP-AVNSSQ-LVSIELQ VSLAQLISVNEREQIMTTNVWLNQEWIDYRLAWKP----SDYEGINM-LRIP--AK---HIWLPDIVLYN-- -NAD-GTY-EVSLYTNAIVQNNGSIRWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVL--- -------------------------KTSMASMDDFTPSGEWDIVALPGRRTVNP------LDP------NYV D----VTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPST-HT-MPPWVKLVFLERLPAYLF---MKR--P- ------------------------------------------------------------------------ ---ENNSPRQKPCNCKKTRAE-----------------------------------------NLCMDPADFY --------------------------KNSTYFVNTASAKKYDMKITDTL----------------------- ---------------------------------------------------------DNVSSHQDFRLRTGT K-----------------------------------------------------FSPEVQEAID-GVSFIAE HMKSDDNDQ-SVIEDWKYVAMVVDRLFLWIFVLVCVLGTVGLFL--QPLFQNHIAATNP------------- ------------------------------------- >ChineseSoftshellTurtle_scaffoldJH208173_2/1-308 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MVL--- -------------------------KTSMASMDDFTPSGEWDIVALPGRRTVNP------LDP------KYV D----VTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPST-HT-MPPWVKVVFLEKLPTILF---MKR--P- ------------------------------------------------------------------------ ---ETTSARQRLSNRRKTKSE-----------------------------------------NLCTNPADLY --------------------------KNSTYFVNTASAKKYNLKVTENS----------------------- ---------------------------------------------------------DNISGHQDFKLRSSM R-----------------------------------------------------FSPEVQEAIE-GVSFIAD HMKSDDNDQ-SVIEDWKYVAMVVDRLFLWIFIFVCVLGTVGLFL--QPLFQNHSAAASP------------- ------------------------------------- >Coelacanth_scaffoldNW005819325/1-517 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------MEPQTFDDWSLAETSHRRSFQ LPVLHESASSASIDEPRKSLAMD---------TEE-RLVGHLL---NPAHYNKLIRP-ATNRSE-VVTVQLM VSLAQLISVHERAQIMTTNCWLTQEWKDYRLMWDP----DEFDGMKK-VRLP--ST---HIWLPDVILYN-- -NAD-GMY-EVSFYSNAVVSYDGSVFWLPPAIYKSACKIEVKHFPFDQQNCTLQFRSWTYDRSEVDLVL--- -------------------------REEVATMDDFTPSGEWDIIYLPGRRNENP---GDSG---------YV D----ITYDFIIRRKPLFYSINLIIPCMLITSLAVLVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLVGKYLMFTMILVTFSIVTSVCVLNVHHRSPTT-HT-MPPWVKVVFLEKLPMFLF---MKQ--P- ------------------------------------------------------------------------ ------RQSCACRRLQQRQQA-----------------------------------------QERRSRGFYF ---------------------GDSSMRSSTCFVNPATVKKYGGHLTNLL----------------------- ---------------------------------------------------------DCNDGLRNGHLRHAG S-----------------------------------------------------CCQNLNEAVD-GVCFVAD HIKSEDKKR-SVIEDWKYVAMVIDRLFLWIFVFVCIFGTLGMFL--QPVFQNSSFDSLPQKTNAA------- ------------------------------------- >Zebrafish_16_chrnb2/1-543 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MMALWTLFCILAIVKSGYGAD---------TEE-RLVEHLL---NPAHYNKLIRP-ATNGSE-VVTVQLM VSLAQLISVHEREQIMTTNVWLTQEWQDYRLTWSP----EEFDGMKK-VRLP--SK---HIWLPDVVLYN-- -NAD-GMY-EVSFYSNAVVSYDGSVFWLPPAIYKSACKIEVKHFPFDQQNCTLSFRSWTYDRTEVDLVL--- -------------------------RADVASMDDFTPSGEWDIIALPGRRNENP------SDP------TYV D----ITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTT-HT-MPPWVKLVFLNKLPALLF---MRQ--P- ------------------------------------------------------------------------ ----RNSSERQRLRQRRRANE-----------------------------------------QQEGGRGGLA ------AGLMAGLGLSGSSSGSKENNEACTCYVNRASVKQFGAELGGGGGGGGSTDGLNGI----------- ---------------------------------------------------------REGGRETREGGANPL QGSALPRGKQQPPTVLTQALLAQ-------------------------------ACPGFEEAVD-GVRFIAN HMKSEDDDR-SVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFL--QPLFQNYTAKTITHTPG--------- ------------------------------------- >Fugu_7_1/1-544 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M DDWPPLLLLLALLAIAGGGLCAD---------TEE-RLVEHLL---NPAHYNKLIRP-ATNGSE-LVTVQLM VSLAQLISVHEREQVMTTNVWLTQEWQDYRLTWIP----EEFDGMLK-VRLP--SK---HIWLPDVVLYN-- -NAD-GVY-EVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTLRFRSWTYDRTEIDLVL--- -------------------------RADVASMDDFTPSGEWDIIALPGRRNENP------GDP------TYV D----ITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTT-HT-MPPWVKMVFLQKLPALLF---MRQ--P- ------------------------------------------------------------------------ -RNSCERQRLRQRRRAQEHKE-----------------------------------------GGCCGEPGGL MVGLGLGNAGSSGGGTTTGIFGKEDSDPCTCYVNRASVKQFGGDLGGAGGSM-------------------- ---------------------------------------------------------DGLNRARDGREGGSG NQSRGKQPAGGPALSHALLAQ---------------------------------ACPGFEEAVE-GVRFIAN HMKSEDDDQ-SVSEDWKYVAMVIDRLFLWIFVFVCVFGTMGMFM--QPLFQNYTAKTINSSPG--------- ------------------------------------- >Medaka_16_1/1-534 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MDGWLPL-LALLAMAGGSLGAD---------TEE-RLVEHLL---NPAHYNKLIRP-ATNGSE-LVTVQLM VSLAQLISVHEREQVMTTNVWLTQEWQDYRLTWVP----EEFDGMLK-VRLP--SK---HIWLPDVVLYN-- -NAD-GVY-EVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTLRFRSWTYDRTEIDLVL--- -------------------------RADVASMDDFTPSGEWDIIALPGRRNENP------ADP------AYV D----ITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTT-HT-MPPWVKLVFLNKLPALLF---MRQ--P- ------------------------------------------------------------------------ ------RNSCERQRLRQRRRA-----------------------------------------QEQREGGMMG ---VGVGGAGGNGGGASTAVFGKDDSDPCTCYVNRASVKQFGGDLGGAGGGSM------------------- ---------------------------------------------------------DGLNRVREGREGGAG ILPRGKQAAGGPALTQALLAQ---------------------------------ACPGFEEAVE-GVRFIAN HMKSEDDDQ-SVSEDWKYVAMVIDRLFLWIFVFVCVFGTLGMFL--QPLFQNYTVKTIASTAG--------- ------------------------------------- >Stickleback_XX_2/1-527 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------GLGAD---------TEE-RLVEHLL---NPAHYNKLIRP-ATNGSE-LVTVQLM VSLAQLISVHEREQVMTTNVWLTQEWQDYRLTWVP----EEFDGMLK-VRLP--SK---HIWLPDVVLYN-- -NAD-GVY-EVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTLRFRSWTYDRTEIDLVL--- -------------------------RADVASMDDFTPSGEWDIIALPGRRNENP------ADP------TYV D----ITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTT-HT-MPPWVKLVFLNKLPALLF---MRQ--P- ------------------------------------------------------------------------ -RNSCERQRLRQRRRAQEQKE-----------------------------------------GGRSGEAGAL MVGLGLGNASGNRGGTSTGVFSKEDSDPCTCYVNRASVKQFGGDLVGAGGGSMDSL---------------- ---------------------------------------------------------NRVRESREGGASGNT PRGKQAAGGPALTQALLAQ-----------------------------------ACPGFEEAVE-GVRFIAN HMKSEDDDQ-SVSEDWKYVAMVIDRLFLWIFVFVCVFGTLGMFM--QPLYQNYTVKTITSSPG--------- ------------------------------------- >Chicken_25/1-491 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---MALLRVLCLLAALRRSLCTD---------TEE-RLVEYLL---DPTRYNKLIRP-ATNGSQ-LVTVQLM VSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKP----EDFDNMKK-VRLP--SK---HIWLPDVVLYN-- -NAD-GMY-EVSFYSNAVISYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVL--- -------------------------KSEVASLDDFTPSGEWDIVALPGRRNENP------DDS------TYV D----ITYDFIIRRKPLFYTINLIIPCILITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTT-HT-MPPWVRTLFLRKLPALLF---MKQ--P- ------------------------------------------------------------------------ ------QQNCARQRLRQRRQT-----------------------------------------QERAAAATLF ---------------------LRAGARACACYANPGAAKAEGL----------------------------- ---------------------------------------------------------NGYRERQGQGPDPPA P-----------------------------------------------------CGCGLEEAVE-GVRFIAD HMRSEDDDQ-SVSEDWKYVAMVIDRLFLWIFVFVCVFGTVGMFL--QPLFQNYATNSLLQLGQGTPTSK--- ------------------------------------- >WesternClawedFrog_scaffoldGL174136/1-478 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------GCLGTD---------TEE-RLVEHLL---DPSRYNKLIRP-ATNGSE-QVTVQLM VSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWDP----AEFDDMKK-VRLP--SK---HIWLPDVVLYN-- -NAD-GMY-EVSFYSNAVVSHDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTELDLVL--- -------------------------RSDVASLDDFTPSGEWDIIALPGRRNENP-----NDST-------YV D----ITYDFIIRRKPLFYTINLIIPCILITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTT-HT-MPPWVKVVFLDKLPTLLF---MKQ--P- ------------------------------------------------------------------------ -------RQNCARQRLRQQRQ-----------------------------------------SQERAAGSFF ---------------------LRDGARSCTCYVNQASVKKYGAQLSEL------------------------ ---------------------------------------------------------PEGVNGFRDRQGKVR Q-----------------------------------------------------CLCGLQEAVD-GVRFIAD HMKSEDDDQ-SVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFL--QPLFQNYTTNALVHMNHAAN------ ------------------------------------- >AnoleLizard_scaffoldGL344076/1-506 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------VLGTD---------TEE-RLVEHLL---DPLRYNKLIRP-ATNGSE-LVTVQLM VSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWDP----EDFDDMKK-VRLP--SK---HIWLPDVVLYN-- -NAD-GMY-EVSFYSNAVVSFDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVL--- -------------------------KSEVASLDDFTPSGEWDIIALPGRRNENP-----NDST-------YV D----ITYDFIIRRKPLFYTINLIIPCILITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTT-HT-MPPWVKVVFLDKLPTLLF---MKQ--P- ------------------------------------------------------------------------ -RQNCARQRLRQKRQGHQRNA-----------------------------------------ALNAAAGSFF ------------LRDGARSCTCYANPSAAKKFPPGGGAGGGAGNNGAEGVNGYRERQGA------------- ---------------------------------------------------------ATTTTTTTTTGQPPG H-----------------------------------------------------CCCGLEEAVD-GVRFIAD HMKSEDDDQ-SVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFL--QPLFQNYATNSLLQIHQGAPGSK--- ------------------------------------- >Opossum_2_1/1-509 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------MPQL PLPMALLLCFGLLGLFPGVLATD---------TEE-RLVEHLL---DPARYNKLIRP-ATNGSE-LVTVQLT VSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKP----EEFDNMKK-VRLP--SK---HIWLPDVVLYN-- -NAD-GVY-EVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVL--- -------------------------KSEVANLDDFTPSGEWDIVALPGRRNENP------DDS------TYV D----ITYDFIIRRKPLFYTINLIIPCILITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTT-HT-MAPWVKVVFLEKLPTVLF---MKQ--P- ------------------------------------------------------------------------ --RHNCARQRLRQRRRQREQE-----------------------------------------GGGVGGGIFF --------------------RDAPGTNSCTCFVNQASVKEFGGVFGAES----------------------- ---------------------------------------------------------AESAHGYRGRAGPVG P-----------------------------------------------------CGCGLKEAAD-GVRFIAD HMRSEDDDQ-SVSEDWKYVAMVIDRLFLWIFVFVCIFGTIGMFL--QPLFQNYATNTFLHLAHPASSSK--- ------------------------------------- >Mouse_3/1-501 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------MARC SNSMALLFSFGLLWLCSGVLGTD---------TEE-RLVEHLL---DPSRYNKLIRP-ATNGSE-LVTVQLM VSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKP----EDFDNMKK-VRLP--SK---HIWLPDVVLYN-- -NAD-GMY-EVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVL--- -------------------------KSDVASLDDFTPSGEWDIIALPGRRNENP------DDS------TYV D----ITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTT-HT-MAPWVKVVFLEKLPTLLF---LQQ--P- ------------------------------------------------------------------------ ------RHRCARQRLRLRRRQ-----------------------------------------REREGAGTLF -------------------FREGPAADPCTCFVNPASMQGLAGA---------------------------- ---------------------------------------------------------FQAEPAAAGLGRSMG P-----------------------------------------------------CSCGLREAVD-GVRFIAD HMRSEDDDQ-SVREDWKYVAMVIDRLFLWIFVFVCVFGTIGMFL--QPLFQNYTATTFLHSDHSAPSSK--- ------------------------------------- >Human_1_CHRNB2/1-502 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------MARR CGPVALLLGFGLLRLCSGVWGTD---------TEE-RLVEHLL---DPSRYNKLIRP-ATNGSE-LVTVQLM VSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKP----EEFDNMKK-VRLP--SK---HIWLPDVVLYN-- -NAD-GMY-EVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVL--- -------------------------KSEVASLDDFTPSGEWDIVALPGRRNENP------DDS------TYV D----ITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTT-HT-MAPWVKVVFLEKLPALLF---MQQ--P- ------------------------------------------------------------------------ ------RHHCARQRLRLRRRQ-----------------------------------------REREGAGALF -------------------FREAPGADSCTCFVNRASVQGLAGAF--------------------------- ---------------------------------------------------------GAEPAPVAGPGRSGE P-----------------------------------------------------CGCGLREAVD-GVRFIAD HMRSEDDDQ-SVSEDWKYVAMVIDRLFLWIFVFVCVFGTIGMFL--QPLFQNYTTTTFLHSDHSAPSSK--- ------------------------------------- >AustralianGostshark_scaffoldNW006890074_4/1-504 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------MLMMALTLRVSFLLLICQS HPTTTGAKINQQKSLKPATLAPN---------AEE-RLADYLL---HADRYNKLIRP-AKNSSE-MVTIAIK VSLSQLISVNEREQIMTTNVWLTQEWNDYRLRWEP----VQYEGVDQ-LRLS--SR---HIWLPDIVLYN-- -NAD-GTY-EVSLYTNAIVYNNGDIFWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDLVL--- -------------------------SSDFASRDDFTPSGEWDIVSLPGRRNEIP------TDP------TYV D----ITYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLDVPLIGKYLMFAMVLVTFSIVTSVCVLNVHHRSPST-HT-MPEWVKKMFLIKLPTLLF---MKR--P- ------------------------------------------------------------------------ -------------ENKNVKEK-----------------------------------------DRNKHSANYV -------------------DIKADKANVETYYVNEEPAKKYNWKL--------------------------- ---------------------------------------------------------ADTSENQDFRKRGPL K-----------------------------------------------------GNPKVQEAVD-GVRFIAN HMKIEDDDQ-SIIEDWKYVAMVIDRLFLWIFVCVCVVGTMGLFL--QPLFQNQNPPSLTPSGG--------- ------------------------------------- >Zebrafish_14_2_chrnb5b/1-487 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MAAQMASGLWFVALTMATVWCAE---------VEE-RLVNYLL---SPDRYNKLIRP-AVNKSQ-QVTIAIQ VSLAQLISVNEREQIMTTNCWLTQVWNDYRLMWDP----EEYEGMRK-VRLP--SQ---HIWLPDIVLYN-- -NAD-GTY-EVSFYSNAVVSNNGEVAWLPPAIYKSACKIEVRDFPFDQQNCTLKFRSWTYDHTEIDLIL--- -------------------------LSDFASRDDFKPSGEWDIVSLPGRKNEDP------NDV------TYL D----ITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-GEKITLCISVLLALTVFLLLISKIVP PTSLAVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPST-HS-MPKWVKYYFLVRLPAFLF---MRR--P- ------------------------------------------------------------------------ ----GESNKRDRFRRKHQQHS-----------------------------------------SSDVPVKSEA ------------------------DEADSTFFVNEDSANHIGWRA--------------------------- ---------------------------------------------------------GELQENSELRKRMAV K-----------------------------------------------------CSADMEEAVK-GVRYIAD KMKSEDDDE-GVVQDWKFVAQVLDRIFLWAFLTVSVLGTILIFT---PAVKMFLSTPPPPSP---------- ------------------------------------- >Zebrafish_1_4_chrnb5a/1-494 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------MGST MGSNCLLYLCLLWLCVARSLAAD---------AEE-RLVDFLL---GPERYNKLIRP-AVNKSQ-QVTIGIK VSLAQLISVNEREQIMTTNVWLTQEWNDYRLVWDP----NEYEGIKK-LRIP--SR---HIWLPDIVLYN-- -NAD-GVY-EVSFYCNAVVSNTGDIFWLPPAIYKSACAIEVRNFPFDQQNCTLKFRSWTYDRTELDLYL--- -------------------------TSDFASRDDYTPSGEWDIVSLPGRRNEDL------SDP------TYL D----VTYDFVIKRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLAVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPST-HR-MPEWVKRVFLHKLPFFLL---MRR--P- ------------------------------------------------------------------------ -----GRSNVRERFRRKHQRK-----------------------------------------SFSSDTKGLR -----------------------LDGDSYFLSDDPGRVCGAWRV---------------------------- ---------------------------------------------------------GDLPEGSEFRQRVKV R-----------------------------------------------------HDPDVDEAIE-GVRFIAE HMKIEDDDE-GIIEDWKYVAMVIDRLFLWIFILVCVVGTLGLFV--QPLFQSYNTPVAEEEYGDF------- ------------------------------------- >Fugu_17_2/1-487 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------SRAEN---------AEK-RLVNYLL---SPERYNKLIRP-AVNKSQ-QVAISIQ VSLSQLISVNEREQIMTTNLWLFQEWNDYRLRWDP----EKYDGIKK-LRIP--SK---HLWLPDIVLYN-- -NAD-GVY-EVSVYCNAVVSNTGDIFWLPPAIYKSACAIEVQNFPFDQQNCTLKFRSWTYDHTEVDFIL--- -------------------------TSDFASRDDFTPSGEWDIVSLPARKNEDP------NDV------TYL D----ITYDFVIQRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-REKIMLCMSVLLALTVFLLLISKIVP PTSLAVPLIGKYLMFTMVLVTFSIVSTVCVLNVHHRSPST-HH-MPDWVKRIFLTRLPTFLL---MRH--P- ------------------------------------------------------------------------ --GSSSVRNKSCQKDAKHSGV------------------------------------GKSRATSVTEKKQYS -----------------NIRLGGIPTDTDSFYAEDTPRRLCWRAGDVP------------------------ ---------------------------------------------------------DGSVGFSDHQRPLGA H-----------------------------------------------------SDTEMEEAVE-GVKYIAE HMKTEDDDE-GIIEDWKYVAMVIDRLFLWIFILVCVVGTLGLFM--QPMFQSYNTPTADDTA---------- ------------------------------------- >Medaka_1_4/1-508 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MKSNAAFLMCFLSLTSSQAEN---------AEE-RLVNYLL---GPERYNKLIRP-AVNKSQ-QVTISIQ VSLSQLISVNEREQIMTTNLWLFQEWNDYRLRWDP----DKYEGIKK-LRIP--SK---LIWLPDIVLYN-- -NAD-GVY-EVSFYCNAVVSNTGDIFWLPPAIYKSACAIEVQNFPFDQQNCTLKFRSWTYDHTEVDLML--- -------------------------TSDFASRDDFTPSGEWDIVSLPGRKNEDP------NDI------TYL D----ITYDFVIRRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-RQKMTLCISVLLALTVFLLLISKIVP PTSLAVPLIGKYLMFTMVLVTFSIVCTVCVLNVHHRSPST-HF-MPEWAKRIFLVRLPTFLL---MRR--P- -----------------------------------------------------------------------G SSSARRKPRQKSGGKNPKGKN-----------------------------------------NFQSIAGNWQ ---------------CSKNRLSGIPMDSDSFYVNEDLAHRCCWKVGDVP----------------------- ---------------------------------------------------------DGGGGLSDFRRSCAD Q-----------------------------------------------------RDADLDEAME-GVRYIAD HMKTEDDDE-GIIQDWKYVGMVIDRLFLWIFILVCVVGTLGLFM--QPLFQSYNTPAADDTEYSDF------ ------------------------------------- >Stickleback_IX_4/1-444 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------NEREQIMTTNLWLFQEWNDYRLRWDP----AKYEGIKK-LRIP--SK---HIWLPDIVLYN-- -NAD-GVY-EVSFYCNAVVSNTGDIFWLPPAIYKSACAIEVQNFPFDQQNCTLKFRSWTYDHTELDLML--- -------------------------TSDFASRDDFTPSGEWDIVSLPARKNEDP------NDI------TYL D----ISYDFVIKRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLAVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPST-HH-MPDWVKRLFLVRLPNFLF---MRRPGP- -----------------------------------------------------------------------S NIRDKLCRKYANRSAVGKNNA-----------------------------------------QGGTDKKQYS -----------------NIRLGGIRTDADSFYVNEDLAHKFCWKVDDVP----------------------- ---------------------------------------------------------DGGGGFSDFRRPSAD Q-----------------------------------------------------WDADVEEAVD-GVRYIAE HMRTEDDDE-GIIEDWKYVAMVIDRLFLWIFILVCLVGTLGLFM--QPLFQSYNVPTADDAEYGDF------ ------------------------------------- >SpottedGar_LG4_4/1-484 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MAAVATVSLTLLILAVTTAYAAD---------AEE-RLVSYLL---GPERYNKLIRP-AVNRSQ-LVTIATQ VSLSQLISVNEREQIMTTNVWLTQEWNDYRLKWDP----QEYEGIKK-LRIP--SQ---HIWLPDIVLYN-- -NAD-GTY-EVSFYCNAVVSSSGDVFWLPPAIYKSACKIEVKNFPFDQQNCTMKFRSWTYDRTEIDLIL--- -------------------------MSDFASRDDFTPSGEWDIVSLPGRKNEDP------EDA------TYV D----ITYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLAVPLIGKYLMFTMVLVTFSIVTSVCVLNIHHRSPST-HT-MPEWVKRVFLDKLPAVLF---MKR--P- ------------------------------------------------------------------------ ----------DNTNVRERFRR-----------------------------------------KQQNSHPDLK ----------------------AGKGDADSFYVNEESAKKYGWKI--------------------------- ---------------------------------------------------------SDLPENTEFRKRMTV K-----------------------------------------------------CNPDMEEAVD-GVRFIAE HMRSEDDDE-SIIEDWKYVAMVIDRLFLWIFVFVCVVGTVGLFL--QPLFQNYNSPHVANKE---------- ------------------------------------- >Fugu_14_4/1-497 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MAVPVKAALAFLVLTAATASCAE---------VEE-RLVSHLL---APDRYNKLIRP-AVNNSQ-QVTIYIQ VSLAQLINVNERDQIMTTNCWLSQVWHDYRLMWNP----EEYEGIKK-IRLP--TQ---HIWLPDIVLYN-- -NAD-GTY-EVSYYSNAVISNNGEVNWLPPAIYKSACKIEVRDFPFDQQNCTLQFRSWTYDHTEIDLIL--- -------------------------VSDYASRDDFKPSGEWDIVSLPGRKNEDP------NDI------RYL D----ITYDFIIKRKPLFYTINLIIPCILITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLAVPLIGKYLMFTMVLVTFSIVTSVCVLNVHHRSPST-HT-MPPWVKRVFLHRLPSFLF---MRR--P- ------------------------------------------------------------------------ --RSSNIRERFRKKHQQRSLS-----------------------------------------DCKLRGVDGG -------------------GPLGVADSSSSFFVNEESAKRYGWKI--------------------------- ---------------------------------------------------------RDLSENTEFRKRMTL K-----------------------------------------------------YNIDVEDAVD-GVRYIAE KMKSEDDDE-GIIEDWKYVAMVIDRLFLWIFVFVCVVGTVGLFI--QPLFQSFNTPIVEEVDHN-------- ------------------------------------- >Medaka_10_4/1-497 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MAVPVKTALALLVLTAGTASCAE---------VEE-RLVNHLL---SPERYNKLIRP-AVNNSQ-QVTIYIQ VSLAQLINVNEREQIMTTNCWLTQGWNDYRLMWDP----DEYDGIKK-IRLP--SQ---HIWLPDIVLYN-- -NAD-GTY-EVSFYSNAVVSNNGEVAWLPPAIYKSACKIEVRDFPFDQQNCTLKFRSWTYDHTEIDLIL--- -------------------------LSDYASRDDFKPSGEWDIVSLPGRKNEDP------NDI------RYL D----ITYDFIIKRKPLFYTINLIIPCILITSLAILVFYLPS-DC-GEKMTLCISVLLALTVFLLLISKIVP PTSLAVPLIGKYLMFAMVLVTFSIVTSVCVLNVHHRSPST-HT-MPPWVKRVFLNQLPSFLF---MRR--P- ------------------------------------------------------------------------ -GSSNIRERFRKKHQKQKYAE-----------------------------------------QKLCGAEGGI --------------------GGGVADSSSSVFVNEDSAKRYGWRI--------------------------- ---------------------------------------------------------SDLSENTEFRRRMTL K-----------------------------------------------------SNIDVEDAVD-GVRYIAE KMKSEDDDE-GIIEDWKYVAMVIDRLFLWIFVCVCVVGTVGLFV--QPLFQNYNTPIVEDLEHN-------- ------------------------------------- >WesternClawedFrog_9_2/1-457 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MDFSLTRLIFLFIAATLVFSSE---------DES-RLINDLF-----KSYNKVVRP-VKAFKD-KVVVTLG LQLIQLINVDEVNQIVTTNVRLKQQWEDVHLKWNP----EDYGGIKK-VRIS--SG---DIWRPDIVLYN-- -NAD-GDF-AIVQETKVLLDYTGKIIWTPPAIFKSYCEMIVTYFPFDLQNCSMKLGTWTYDGSLVVINP--- -------------------------ESDRPDLSNFMESGEWYMKDYRGWKHWVY-Y-DCCPET------PYL D----ITYHFLLQRLPLYFIVNVVIPCLLFSFLTGLVFYLPT-DS-GEKITLSVSVLLSLVVFLLVIVELIP STSSAVPLIGKYMLFTMVFVITSIVITVIVINTHHRSPST-HI-MPQWLKKIFIETIPRVMFFSTMKR--P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------AQDQQKKKIFTEDIDISDI------------------------------- ---------------------------------------------------------SGKLGPAAVKYQSPI L-----------------------------------------------------KNPDVKSAIE-GAKYIAE TMKSDQESN-KASEEWKFVAMVLDHLLLAVFMIVCIIGTLAIFA--GRLIELHMQG---------------- ------------------------------------- >WesternClawedFrog_9_1/1-457 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MDYTASCLIFFFIAAGPVFSSD---------HET-RLIGDLF-----ANYNKVVRP-VETYKD-QVVVTVG LQLIQLINVDEVNQIVSTNIRLKQQWVDVNLKWDP----AKYGGVKK-LRIP--SS---EVWCPDLVLYN-- -NAD-GDF-AISKDTKILLEHTGKITWTPPAIFKSYCEIIVTHFPFDQQNCSMKFGTWTYDGTLVVINP--- -------------------------DRDRPDLSNFMASGEWMMKDYRCWKHWVY-Y-TCCPDK------PYL D----ITYHFVLQRLPLYFIVNVIIPCLLFSFLTGLVFYLPT-DS-GEKMTLSISVLLSLTVFLLVIVELIP STSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPST-HT-MPPWVRKIFIDTIPNIMFFSTMKR--P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------SQEKQPQTTFAEEMDISDI------------------------------- ---------------------------------------------------------SGKLGPAAVTYQSPA L-----------------------------------------------------KNPDVKSAIE-GIKYIAE TMKSDQESN-KASEEWKFVAMVLDHILLAVFMTVCVIGTLAVFA--GRIIEMNMQD---------------- ------------------------------------- >AustralianGhostshark_scaffoldNW006890067/1-461 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------MVP SNDLRVLSVTLFLTFAGSVLASE---------HET-RLLAELF-----KNYNKVLRP-VKSHND-IVNITVG LQLIQLINVDEVNQIVETNVRLRQQWVDWNLGWKP----ADYGGIEK-IRVA--SS---NLWLPDIVLYN-- -NAD-GDF-AIVHMTKVLLEYTGKIIWTPPAIYKSYCEIIVTHFPFDQQNCSMKLGTWTYDGTSVAIFP--- -------------------------ENDRPDLSNFMESGEWVMKDYRGWKHWVY-Y-TCCPDT------PYL D----ITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPT-DS-GEKMTLSISVLLSLTVFLLVIVELIP STSSAVPLIGKYMLFTMIFVITSIIITVIVINTHHRSPST-HT-MPQWVRKIFIDTIPNVMFFSTMKR--P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------TKDKQKKRIFNDEVDISDI------------------------------- ---------------------------------------------------------SGKQEPASITFHTPL T-----------------------------------------------------KNPDVKSAIE-GVKYIAE HMKSDQESS-DAAEEWKFVAMVIDHILLGVFMMVCIIGTLAVFA--GRLIELNMQG---------------- ------------------------------------- >Opossum_4_1/1-457 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MESIPVLLLLSLCSAGLILGSE---------HET-RLVAKLF-----ENYNSVVRP-VEDHRQ-AVQVTVG LQLIQLINVDEVNQIVTTNVRLKQQWIDYNLKWNP----EEYGGLKK-IHIP--SE---NIWRPDLVLYN-- -NAN-GDF-AIVKFTKVLLDYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGTVVAINP--- -------------------------ENDRPDLSNFMESGEWVIKESRGWKHWVF-Y-ACCPDT------PYL D----ITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPT-DS-GEKMTLSISVLLSLTVFLLVIVELIP STSSAVPLIGKYMLFTMVFVIASIVITVIVINTHHRSPST-HV-MPEWVRKVFIHTIPNVMFFSTMKR--P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------SREKQEKKIFTEDIDISEI------------------------------- ---------------------------------------------------------SGKPGPQTMAFHSPL I-----------------------------------------------------KHPDVKSAIE-GVKYIAE TMKSEQESN-NAAEEWKFVAMVMDHLLLGIFMLVCIIGTLAVFA--GRLIELNQQG---------------- ------------------------------------- >Mouse_2/1-457 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MELSTVLLLLGLCSAGLVLGSE---------HET-RLVAKLF-----EDYSSVVRP-VEDHRE-IVQVTVG LQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNP----DDYGGVKK-IHIP--SE---KIWRPDVVLYN-- -NAD-GDF-AIVKFTKVLLDYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINP--- -------------------------ESDQPDLSNFMESGEWVIKEARGWKHWVF-Y-SCCPTT------PYL D----ITYHFVMQRLPLYFIVNVIIPCLLFSFLTSLVFYLPT-DS-GEKMTLSISVLLSLTVFLLVIVELIP STSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPST-HI-MPEWVRKVFIDTIPNIMFFSTMKR--P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------SRDKQEKRIFTEDIDISDI------------------------------- ---------------------------------------------------------SGKPGPPPMGFHSPL I-----------------------------------------------------KHPEVKSAIE-GVKYIAE TMKSDQESN-NAAEEWKYVAMVMDHILLGVFMLVCLIGTLAVFA--GRLIELHQQG---------------- ------------------------------------- >Human_2_1_CHRNA1/1-457 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MEPWPLLLLFSLCSAGLVLGSE---------HET-RLVAKLF-----KDYSSVVRP-VEDHRQ-VVEVTVG LQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNP----DDYGGVKK-IHIP--SE---KIWRPDLVLYN-- -NAD-GDF-AIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINP--- -------------------------ESDQPDLSNFMESGEWVIKESRGWKHSVT-Y-SCCPDT------PYL D----ITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPT-DS-GEKMTLSISVLLSLTVFLLVIVELIP STSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPST-HV-MPNWVRKVFIDTIPNIMFFSTMKR--P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------SREKQDKKIFTEDIDISDI------------------------------- ---------------------------------------------------------SGKPGPPPMGFHSPL I-----------------------------------------------------KHPEVKSAIE-GIKYIAE TMKSDQESN-NAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFA--GRLIELNQQG---------------- ------------------------------------- >AnoleLizard_scaffoldGL343377/1-457 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MDVCCLPLLLLLGPAVLVRCSS---------HET-RLVSDLF-----SKYNKVVRP-VSNHRD-PVRVTVG LQLIQLINVDEVNQIVTTNVRLKQQWMDVNLKWNP----EDYGGVKQ-IRIP--SE---DIWRPDLVLYN-- -NAD-GDF-AINKFTKILLNYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGTMVVINP--- -------------------------ESDRPDLSNYMGSGEWIMKDYRGWKHEVT-Y-ACCPDL------PYL D----ITYHFVMLRLPLYFIVNVIIPCLLFSFLTGLVFYLPT-DS-GEKMTLSISVLLSLTVFLLVIVELIP STSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRNPST-HT-MPQWVRKIFIDTIPNLMFFSTMKR--P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------SKNKQEKKIFSEDIDISEI------------------------------- ---------------------------------------------------------SGKQGPATVNFQSSL I-----------------------------------------------------KNPEVKSAIE-GIKYIAE TMKSDQESN-NAAEEWKFVAMVVDHLLLGIFMSVCIIGTLAVFA--GRLIELHQQG---------------- ------------------------------------- >Chicken_7/1-455 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---MSVSCSRSLRAFAGPALCYE---------HET-RLVDDLF-----RDYSKVVRP-VENHRD-AVVVTVG LQLIQLINVDEVNQIVTTNVRLKQQWTDINLKWNP----DDYGGVKQ-IRIP--SD---DIWRPDLVLYN-- -NAD-GDF-AIVKYTKVLLEHTGKITWTPPAIFKSYCEIIVTYFPFDQQNCSMKLGTWTYDGTMVVINP--- -------------------------ESDRPDLSNFMESGEWVMKDYRGWKHWVY-Y-ACCPDT------PYL D----ITYHFLMQRLPLYFIVNVIIPCLLFSFLTGFVFYLPT-DS-GEKMTLSISVLLSLTVFLLVIVELIP STSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPST-HT-MPPWVRKIFIDTIPNIMFFSTMKR--P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------SRDKPDKKIFAEDIDISEI------------------------------- ---------------------------------------------------------SGKQGPVPVNFYSPL T-----------------------------------------------------KNPDVKNAIE-GIKYIAE MMKSDQESS-NAADEWKFVAMVLDHLLLVIFMLVCIIGTLAVFA--GRLIELNQQG---------------- ------------------------------------- >Medaka_15/1-459 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------MK LPIVQVLLAWIFCLFTGSVLGSE---------YET-RLVKTLF-----TGYNKVVRP-VTHFSQ-AVEVTVG LQLIQLISVDEVNQIVTSNVRVKQQWTDVNLKWNP----DDYGGIKK-IRVP--ST---DIWKPDLVLYN-- -NAD-GDF-AIIHETKVLLEYSGKITWNPPAIFKSYCEIIVLHFPFDLQNCSMKLGIWSYDGLLVVINP--- -------------------------ESDKPDLSNFMESGEWVLKDSRCWKHWVQ-Y-TCCQDT------PYL D----ITYHFLMLRLPLYFIVNVIIPCLLFSFLTALVFYLPT-DS-GEKMTLSISVLLSLTVFLLVIVELIP STSSAVPLIGKYMLFTMVFVIASIIITVIVINVHHRSPST-HT-MPQWIRKVFIETIPNMMVFSTMKR--P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------GQEIRQRRFFPTDMDISDI------------------------------- ---------------------------------------------------------SGNLPPTSITYQSPI I-----------------------------------------------------KNPDVRSAIE-GVKHIAE TMKLDEESN-NAAEEWKFVAMVLDHILLCVFMGVCIIGTVAVFA--GRLIELNML----------------- ------------------------------------- >Fugu_4_2/1-459 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------MN LSVVQILLAGSLSVFIAPVFCSE---------DET-RLVKTLF-----TGYNKVVRP-VNHFSE-PVVVTVG LQLIQLISVDEVNQIVTSNVRLRQQWVDVNLNWNP----DDYGGIRK-IRVP--ST---DIWKPDLVLYN-- -NAD-GDF-AIIHETKVLLEHTGKIIWNPPAIFKSYCEIIVLHFPFDLQNCSMKLGTWTYDGLLVVINP--- -------------------------DSDRPDLSNFMESGEWVLKDYRSWKHWVY-Y-TCCPDT------PYL D----ITYHFLMLRLPLYFIVNVIIPCMLFSFLTGLVFYLPT-DS-GEKMTLSISVLLSLTVFLLVIVELIP STSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPST-HT-MPPWIRKVFIETIPNMMFFSTMKR--P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------SQEIRQKRLFPTDMDISDI------------------------------- ---------------------------------------------------------SGNPTPTSVTYQSPI V-----------------------------------------------------KNPDVRSAIE-GVKYIAE TMKSDEESN-NAAEEWKFVAMVLDHILLCVFMAVCIIGTLAVFA--GRLIELNML----------------- ------------------------------------- >Stickleback_VI_2/1-440 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------PVSCSE---------AET-RLVKKLF-----TGYSKVVRP-VDHFSD-AVVVSVG LQLIQLISVDEVNQIVTSNVRLKQRWRDVNLNWDP----DDYGGIRK-IRVP--ST---DIWKPDLVLYN-- -NAD-GDF-AIIHQTKVLLEHTGMITWNPPAIFKSYCEIIVLHFPFDLQNCSMKLGTWTYDGLLVVINP--- -------------------------DSARPDLSNFMESGEWVLKDYRSWKHTVN-YSCCPNKP-------YL D----ITYHFLMLRLPLYFIVNVIIPCMLFSFLTGLVFYLPT-DS-GEKMTLSISVLLSLTVFLLVIVELIP STSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPST-HT-MPAWIRKVFIETIPNMMFFSTMKR--P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------SLEIRQMRMFPTDMDISDI------------------------------- ---------------------------------------------------------SGNPAPTSDTYVSPI T-----------------------------------------------------KNPDVRRAIE-GVKYIAE TMKSDEESN-NAAEEWKFVAMVLDHILLCVFMAVCIIGTLAVFA--GRLIELNTL----------------- ------------------------------------- >Medaka_21/1-456 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MGTLFFAFQVIILAGAAFASS---------DET-RLVKTLF-----TGYNKVVRP-VNHYKD-PVVVTVG LQLIQLISVDEVNQIVSSNVRLKQQWKDVNLQWNP----EDYGGIRK-IRVP--ST---DIWRPDLVLYN-- -NAD-GDF-AIVHETKVLLEHTGMITWNPPAIFKSYCEIIVLHFPFDLQNCTMKLGTWTYDGNLVVVNP--- -------------------------DSDRPDLSNFMESGEWVMKDYRGWKHWVY-Y-ACCQDT------PYL D----ITYHFLMLRLPLYFIVNVIIPCMLFSFLTGLVFYLPT-DS-GEKMTLSISVLLSLTVFLLVIVELIP STSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPST-HT-MPDWVRKVFIETIPNLMFFSTMKR--P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------AKEKQNKPVYTAEFDISE-------------------------------- ---------------------------------------------------------ISGNQATAVHYQSPL T-----------------------------------------------------KNPDVRSAIE-GVKYIAE TMKSDEESN-NAAEEWKFVAMVLDHILLCVFMGVCLIGTLGVFA--GRLIELSTYEA--------------- ------------------------------------- >Fugu_1_2/1-454 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MNTALFSFHLILLAGGAWASK---------DET-RLVKTLF-----TGYNKVVRP-VTHFKD-PVVVTVG LQLIQLINVDEVNQIVSSNVRLKQQWKDVNLQWNP----DDYGGIKK-IRVP--ST---DIWRPDLVLYN-- -NAD-GDF-AIVHETKVLLEHTGMITWNPPAIFKSYCEIIVLHFPFDLQNCSMKLGTWTYDGNLVVVNP--- -------------------------DSDRPDLSNFMESGEWVMKDFRGWKHWVY-Y-ACCPDT------PYL D----ITYHFLMLRLPLYFIVNVIIPCMLFSFLTGLVFYLPT-DS-GEKMTLSISVLLSLTVFLLVIVELIP STSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPST-HT-MPEWVRTVFIETIPNIMFFSTMKR--P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------GKEKQNKSIQPADFDISE-------------------------------- ---------------------------------------------------------ISGNQATAVPYQTSL T-----------------------------------------------------KNPDVRSAIE-GVKYIAE TMKSDEESN-NAAEEWKFVAMVLDHILLCVFMAVCLIGTLGVFA--GRLIELSML----------------- ------------------------------------- >Stickleback_XVI/1-458 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M ARMKPVFFIFYLVILAGAAWGSS---------DET-RLVKTLF-----TGYNKVVRP-VNHFKD-PVVVTVG LQLIQLISVDEVNQIVSSNVRLKQQWKDVNLQWKP----EDYSGIKK-IRVP--ST---DIWRPDLVLYN-- -NAD-GDF-AIVHETKVLLEHTGMITWNPPAIFKSYCEIIVLHFPFDLQNCSMKLGTWTYDGNLVVVNP--- -------------------------DSERPDLSNFMESGEWVMKDFRGWKHWVY-Y-ACCPDT------PYL D----ITYHFLMLRLPLYFIVNVIIPCMLFSFLTGLVFYLPT-DS-GEKMTLSISVLLSLTVFLLVIVELIP STSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPST-HT-MPNWVRTVFIETIPNIMFFSTMKR--P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------GKEKQAKSSIYGADFDISD-------------------------------- ---------------------------------------------------------ISGNQTTSITYQSPI T-----------------------------------------------------KNPDVRSAIE-GVKYIAE TMKSDEESN-NAAEEWKFVAMVLDHILLCVFMAVCLIGTLGVFA--GRLIELSML----------------- ------------------------------------- >Zebrafish_6_1_chrna1/1-456 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MNYFILILPILPYLYGPAVCSE---------DET-RLVKTLF-----TGYNKVVRP-VSHFKD-PVVVTVG LQLIQLISVDEVNQIVTSNVRLKQQWKDVHLQWNP----DDYGGIRK-IRIP--ST---DLWKPDLVLYN-- -NAD-GDF-AIVHETKVLLEHTGMITWTPPAIFKSYCEIVVLHFPFDLQNCSMKLGTWTYDGNLVIINP--- -------------------------DSDRPDLSNFMESGEWVMKDYRSWKHWVY-Y-ACCPDT------PYL D----ITYHFLLLRLPLYFIVNVIIPCMLFSFLTGLVFYLPT-DS-GEKMTLSISVLLSLTVFLLVIVELIP STSSAVPLIGKYMLFTMIFVIASIIITVIVINTHHRSPST-HI-MPAWVRKIFIDTIPNMMFFSTMKR--P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------SQERQEKRLFPADFDISDI------------------------------- ---------------------------------------------------------SGKPMPASVTYHSPI T-----------------------------------------------------KNPDVRSAIE-GVKYIAD TMKSDEESN-NAAEEWKFVAMVLDHILLCVFMAVCIIGTLGVFA--GRLIELSML----------------- ------------------------------------- >Coelacanth_scaffoldNW005824597/1-333 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --MKFRLSLVLILFSAGLSLCSY---------HET-RLVSTLF-----KNYNKVVRP-VEDYSD-AVVVTVG LQLIQLISVDEVNQIVTTNVRLKQQWKDVNLEWNP----DDYGGIKK-IRIP--ST---DIWRPDLVLYN-- -NAD-GDF-NIVHQTKVLLEYTGKITWTPPAIFKSYCEIIVTYFPFDLQNCSMKLGTWTYDGTCVVINP--- -------------------------ESDRPDLSNFMESGEWVMKDYRGWKHWVY-Y-ACCPET------PYL D----ITYHFLMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPT-DS-GEKMTLSISVLLSLTVFLLVIVELIP STSSAVPLIGKYMLFTMVFVITSIIITVIVINIHHRSPST-HT-MPMWVRK--------------------- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------- >SpottedGar_LG12/1-437 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------SE---------HET-RLVKDLF-----KGYNKVVRP-VENYKD-PVVVTVG LQLIQLISVDEVNQIVTTNVRLKQQWKDVNLKWEP----DSYGGIKK-IRIP--ST---DIWRPDLVLYN-- -NAD-GDF-AIVHETKVLLEHTGMITWTPPAIFKSYCEIIVTYFPFDLQNCSMKLGTWTYDGTSVIINP--- -------------------------ESDRPDLSSFMESGEWVMKDYRGWKHWVY-Y-ACCPDT------PYL D----ITYHFLMLRLPLYFIVNVIIPCLLFSFLTGLVFYLPT-DS-GEKMTLSISVLLSLTVFLLVIVELIP STSSAVPLIGKYMLFTMVFVITSIIITVIVINTHHRSPST-HT-MPQWVRKIFIDTIPNIMFFSTMKR--P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------SREKQEKRIFVTDMDISEI------------------------------- ---------------------------------------------------------SGKPTPASITFQSPI T-----------------------------------------------------KNPDVRTAIE-GVKYIAE TMKSDQESN-NAAEEWKFVAMVIDHVLLCVFMLVCIIGTLSVFA--GRLIELNQQG---------------- ------------------------------------- >AustralianGhostshark_scaffoldNW006892316/1-372 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------DEKNQLMTTNVWLKQEWMDVTLKWDP----EKYAGIKS-IRVP--SD---SIWSPDIVLYD-- -NAD-GNF-EGSV-TKSIIRYDGTITWNPPANYKSSCTIDVTFFPFDLQNCSMKFSSWTYDGSQVDIKL--- -------------------------VDKQVDKTDFFDNGEWEIISATGHKGNRT------DDY-----YWYP H----ITYSFVIRRLPLFYTLFLIIPCIGLSFLTILVFYLPS-NA-REKISLCTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLVFTMFFVTLSIVITVFTINIHHRSSFT-HNTMAPWIRKLFLHKLPQILC---MRS---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------RVDRCQARSFCRTEV ------------------------------------------------------KRHTLEAALD-SIRYIAN HTMKESNVR-EVVEDWRFVAQVLDRMFLWTFLFVSILGSMLLFI--PVIHNWAQITIPVLK----------- ------------------------------------- >Zebrafish_18_1_chrna5/1-466 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MVTAL SLVRALLPLVCSAVLCSAIGPP---MLSSYAKTED-KLFKHLF-----SNYQKWVRP-IEDLNT-TIQVKFG LAISQLVDVDEKNQLMTTNVWMKQEWTDLKLRWDP----DHYLGITS-IRVP--SD---SIWIPDIVLYD-- -NAD-GNF-EATV-TKAVVRFDGTISWTPPANYKSACTIDVTFFPFDLQNCSMKFGSWTYDGSQVDILL--- -------------------------EDVHVDKRDYFDNGEWEIVKATGNRGLRR--DGTFF---------YP S----ITYSFIIRRLPLFYTLFLIIPCIGLSFLTVLVFYLPS-NG-GEKISLCTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLVFTMIFVTLSIVITVFAINIHHRSSSTHHS-MAPWVRRIFLHHLPRLLC---MRS---- ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------HVDRYATSAGTRTG-------------------------------- ---------------------------------------------------------GLGYGKSLSQDTNQL D-----------------------------------------------------AEHNLQAALE-SIRYITR HVVKENEVR-EVVQDWKFVAQVLDRVFLWAFLLVSLLGSALLFI--PVIYKWASIIVPSYAEITS------- ------------------------------------- >Medaka_3_4/1-476 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------MMLRAGGA TISVILLLLLPLLCWCHLCHSLRVPKLSSYAKAED-TLFKHLF-----GTYQKWVRP-IEYLNQ-TIPVKFG LAISQLVDVDEKKQLMTTNVWLKQEWIDMKLRWKP----EDYLGITT-IRVP--SD---RIWLPDVVLYD-- -NSD-GRF-EGTV-TKAVVKYDGTISWNPPANFKSACTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIIL--- -------------------------EDFHVDKKDYFDNGEWEIVKATGSRGLRT--DGSTS---------YP T----ITYFFIIRRLPLFYTLFLIIPCIGLSFLTILVFYLPS-NG-NEKISLCTSVLVSLTVFLLVIEEIIP SSSKAIPLIGEYLVFTMIFVTLSIIITVFAINIHYRSSSTHHD-MAPWVRRIFLHRLPKLLC---MRS---- ------------------------------------------------------------------------ ------------------------------------------------------------------HVDRYA ----------------------------TAGLAGKGKVTV-------------------------------- ---------------------------------------------------------QEKTKDSTPDLTHIL H-----------------------------------------------------TRHNLQTALE-SIRYITM HVVKENQVR-EVVQDWKYVAQVLDRMFLWAFFLVSVLGSALLFV--PVIYKWASIIVPDYAGSIL------- ------------------------------------- >Fugu_13_2/1-461 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------MQL PVQMREKEGSCISEVPKLSSCA---------KAED-KLFKYLF-----GNYQKWVRP-VDHLNQ-TIRVKFG LAISQLVDVDEKNQRMTTNVWMKQEWTDMKLRWNP----EEYAGITI-IRVP--SD---RIWRPDVVLYD-- -NSD-GRF-EGTI-TKAVVKYDGTITWTAPANYKSACTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIIL--- -------------------------EDFHVDKRDYFDNGEWEIVKATGSRGLRM--DGSTS---------YP T----ITYFFIIRRLPLFYTLFLIIPCIGLSFLTILVFYLPS-NG-GEKISLCTSVLVSLTVFLLVIEEIIP SSSKAIPLIGEYLVFTMIFVTLSIVITVFAINVHHRSSST-HNDMAPWVRRVFLHHLPKLLC---MRS---- ------------------------------------------------------------------------ ------------------------------------------------------------------HVDRYA -------------------------------TSGAARTRG-------------------------------- ---------------------------------------------------------LGMAEGSEPELTPLF Y-----------------------------------------------------TRQNLKAALD-SIRYITM HVVKENEVR-EVVQDWKFVAQVLDRMFLWAFLLVSILGSALLFI--PVIYKWASIIVPNHETMVFGN----- ------------------------------------- >Stickleback_II_3/1-449 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------MCHSLRVPKLSSFA---------KAED-KLFKYLF-----GNYQKWVRP-VEYLNQ-TISVKFG LAISQLVDVDEKNQQMTTNVWMKQEWIDRKLRWNP----DDYLGITT-IRVP--SN---RIWLPDVVLYD-- -NSD-GRF-EATV-TKAVVKYNGTISWTPPANYKSACTIDVTFFPFDLQNCSMKFGSWTYDGSQVDITL--- -------------------------EEFHVDKKDYFDNGEWEIVKATGSRGLRT--DSSST---------YP T----ITYFFIIRRLPLFYTLFLIIPCIGLSFLTILVFYLPS-NG-GEKISLCTSVLVSLTVFLLVIEEIIP SSSKAIPLIGEYLVFTMIFVTLSIVITVFAINIHHRSSSTHHN-MAPWVRRIFLHRLPKLLC---MRS---- ------------------------------------------------------------------------ ------------------------------------------------------------------HADRYA --------------------------TAGVARTGGAER---------------------------------- ---------------------------------------------------------EGKMKDSAPELTSLL Y-----------------------------------------------------TKHNLQAALE-SIRYITM HVVKENEVR-EVVQDWKFVAQVLDRMFLWAFLLVSILGSALLFI--PVIYKWANIIVPKHFGS--------- ------------------------------------- >SpottedGar_LG3_4/1-459 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MMRADR RIVMLLTFLCYSCYLCSSLGIS---NLSSYAKTED-KLFKELF-----RNYQKWVRP-VEHLNG-TVRVKFG LAISQLVDVDEKNQLMTTNVWLKQEWVDVKLRWNP----DDYLGITS-IRVP--SD---SIWIPDIVLYD-- -NAD-GRF-EGSV-TKTVVKFDGTISWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGTQVDIIL--- -------------------------EDFHVDKRDYFDNGEWEIVTATGSRGVRT--DGSCS---------YP F----ITYSFIIRRLPLFYTLFLIIPCIGLSFLTILVFYLPS-NG-GEKISLCTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLVFTMIFVTLSIVITVFAINIHHRSSSTHHD-MAPWVRRIFLHRLPKLLC---MRS---- ------------------------------------------------------------------------ ------------------------------------------------------------------HVDRYA ------------------------------------------------------------------------ ---------------------------------------------------------TAAGGDVKSPGFETP S-----------------------------------------------------SRYNLQAALD-SIRYITL HVVKENEVR-EVVEDWKFVAQVLDRVFLWTFLLVSVLGSILLFI--PVIYKWANIIVPNYVGGSS------- ------------------------------------- >Coelacanth_scaffoldJH127300_1/1-428 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------LLTLAKIED-CLFKDLF-----KDYQKWIRP-VDHLND-TVRVKFG LAISQLVDVDEKNQLMTTNVWLRQEWVDVKLRWNP----DDYAGITS-IRVP--SD---SIWIPDIVLYD-- -NAD-GRF-EGSI-TKTVVKYDGNIIWTQPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDITL--- -------------------------EDYHVDKREFFDNGEWEIITATGNRGNKT--DGCCW---------YP F----ITYSFIIRRLPLFYTLFLIIPCIGLSLLTILVFYLPS-NG-GEKISLCTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLVFTMIFVTLSIVITVFAINIHHRSSST-HNPMAPWVRKIFLHKLPKILC---MRS---- ------------------------------------------------------------------------ ------------------------------------------------------------------HVDRYF ------------------------------------------------------------------------ ---------------------------------------------------------TTKEEAKTIYGSEP- ------------------------------------------------------SRNTLEAALD-SIRYITR HVMKENDVR-EVVEDWKFVAQVLDRMFLWTFLVVSILGSVLLFI--PVIYKWANIIVPVYAGNNE------- ------------------------------------- >WesternClawedFrog_3_3/1-476 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------MLLPGTEQKDCVIQRMPW CAEYLLWLFLCLDILHGACGIS---EPSYIAKSED-RLFKYLF---QQQDYQRWVRP-VEHLND-TVKVKFG LAITQLVDVDEKNQLMTTNVWLKQEWVDVKLRWDP----NEFAGITS-IRVP--SD---SIWIPDIVLYD-- -NAD-GRF-EGSV-TKAVVRYDGTINWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIIL--- -------------------------EDYHVDKRDFFDNGEWEIVNATGNKGNRT--DGCCF---------YP Y----ITYSFIIKRLPLFYTLFLIIPCIGLSFLTILVFYLPS-NE-GEKISLCTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLVFTMIFVTLSIVLTVFAINIHNRSSAT-HNAMAPWVRKIFLHKLPKLLC---MRS---- ------------------------------------------------------------------------ ------------------------------------------------------------------HVDRYF ------------------------------------------------------------------------ -----------------------------------------------------------TRKDETGKVRGPE S-----------------------------------------------------SRNTLEAALD-SIRYITR HVMKEHEVQ-EVVEDWKFVAQVLDRMFLWTFLLVSVIGSLFLFI--PVIHKWANIIVPVHIGNMYGDKNT-- ------------------------------------- >Chicken_10_2/1-432 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------VSEPSFVA---------KSED-RLFKHLF-----EDYQRWVRP-VEHLND-TIKIKFG LAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNP----EDYAGITS-IRVP--SD---SIWIPDIVLYD-- -NAD-GRF-EGT-STKTVVKYDGTIAWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIIL--- -------------------------EDYDVDKRDFFDNGEWEIVTATGSKGNRT--DGCCW---------YP F----VTYSFIIRRLPLFYTLFLIIPCIGLSFLTVLVFYLPS-NE-GEKISLCTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLVFTMIFVTLSIVITVFAINIHHRSSST-HNAMAPWVRKIFLHKLPKLLC---MRS---- ------------------------------------------------------------------------ ------------------------------------------------------------------HVDRYF ------------------------------------------------------------------------ -----------------------------------------------------------AQKEEKGNMSGSE S-----------------------------------------------------SRNTLEAALD-SIRYITR HVMKENEVR-EVVEDWKFIAQVLDRMFLWAFLLVSIIGSLVLFI--PVIHKWASIIVPVHIGSTNT------ ------------------------------------- >ChineseSoftshellTurtle_scaffoldNW005854616/1-432 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------ISELTFIA---------KSED-RLFKHLF-----QDYQKWVRP-VQHLND-TIQIKFG LAISQLVDLDEKNQLMTTNVWLKQEWIDVKLRWQP----EDYSGITS-IRVP--SE---SIWIPDIVLYD-- -NTD-GRF-EGT-STKAVVKYDGTVAWTPPANYKSLCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIIL--- -------------------------EDYDVDKRDFFDNGEWEIVTATGSKGNKT--DGCCW---------YP F----ITYSFVIRRLPLFYTLFLIIPCIGLSFLTILVFYLPS-NE-GEKISLCTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLVFTMIFVTLSIVITVFAINIHHRSSST-HNAMAPWVRKIFLHKLPKLLC---MRS---- ------------------------------------------------------------------------ ------------------------------------------------------------------HVDRYF ------------------------------------------------------------------------ ---------------------------------------------------------AQKEETRNISASES- ------------------------------------------------------SRNTLEAAIE-SIRYITR HIMKENDVR-EIVEDWKFIAQVLDRMFLWTFLLASIIGSIGLFI--PVIYKWANIVIPVHIGNIHT------ ------------------------------------- >Opossum_1_2/1-445 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MLLLVGVSAPGSGISEPSFEA---------KCED-RLFKNLF-----QDYERWVRP-VKHLND-KINIKFG LAISQLVDVDEKNQLMTTNVWLKQEWVDVKLRWNP----DDYAGIKA-IRVP--SD---SIWTPDIVLFD-- -NAD-GRF-EGT-STKTVVRYDGTVAWTPPGNYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDLVL--- -------------------------EDYDVDKRDFFDNGEWEIVSATGIKGNRT--DGCCW---------YP Y----VTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPS-NE-GEKICLCTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLVFTMIFVTLSIMVTVFAININHRSSST-HNPMAPWVRKIFLHQLPKLLC---MRS---- ------------------------------------------------------------------------ ------------------------------------------------------------------HVDRYF ------------------------------------------------------------------------ -----------------------------------------------------------AHKEGAEKSNGAR S-----------------------------------------------------PRNTLEAALD-SIRYITR HVRKENDVR-EVVEDWKFIAQVLDRMFLWTFLLVSIIGSLGLFV--PVIYKWANIPITNHTGNANK------ ------------------------------------- >Mouse_9_1/1-438 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------MQISNAGLPELSSAA-------KHED-SLFRDLF-----EDYEKWVRP-VEHLSD-KIKIKFG LAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNP----DDYGGIKI-IRVP--SD---SLWIPDIVLFD-- -NAD-GRF-EGA-STKTVVRYNGTVTWTQPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIIL--- -------------------------EDQDVDRTDFFDNGEWEIMSAMGSKGNRT--DSCCW---------YP C----ITYSFVIKRLPLFYTLFLIIPCIGLSFLTVVVFYLPS-NE-GEKISLCTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSST-HNAMAPWVRKIFLHKLPKLLC---MRS---- ------------------------------------------------------------------------ ------------------------------------------------------------------HADRYF ------------------------------------------------------------------------ ---------------------------------------------------------TQREEAEKDGGPK-- ------------------------------------------------------SRNTLEAALD-CIRYITR HVVKENDVR-EVVEDWKFIAQVLDRMFLWTFLLVSIIGTLGLFV--PVIYKWANIIVPVHIGNTIK------ ------------------------------------- >Human_15_2_CHRNA5/1-468 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------MAARGSGPRALRL LLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHED-SLLKDLF-----QDYERWVRP-VEHLND-KIKIKFG LAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNP----DDYGGIKV-IRVP--SD---SVWTPDIVLFD-- -NAD-GRF-EGT-STKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIIL--- -------------------------EDQDVDKRDFFDNGEWEIVSATGSKGNRT--DSCCW---------YP Y----VTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPS-NE-GEKICLCTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSST-HNAMAPLVRKIFLHTLPKLLC---MRS---- ------------------------------------------------------------------------ ------------------------------------------------------------------HVDRYF ------------------------------------------------------------------------ ---------------------------------------------------------TQKEETESGSGPKS- ------------------------------------------------------SRNTLEAALD-SIRYITR HIMKENDVR-EVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFV--PVIYKWANILIPVHIGNANK------ ------------------------------------- >AustralianGhostshark_scaffoldNW006890074_2/1-480 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------MQLLLRLVVCA LSLSGNTVVMNISLTCTISAAK---TMKLLAEMED-ALLRNLF-----RGYQKWVRP-VQNCND-TITVKFG LEISQLVDVDEKNQLMTTNVWLKQEWNDYKLAWDP----DDYGGINA-IRVP--SE---SIWLPDIVLYE-- -NAD-GRF-EGSLMTKAIVKHNGAVKWTPPASYKSSCTIDVTFFPFDRQNCSMKFGSWTYDGSLVDLIL--- -------------------------VDENVDRKDFFDNGEWEILNATGMKGTRS---DDCYV--------YP F----ITYYFVLRRLPLFYTLFLIVPCLGLSFLTVLVFYSPS-DE-GEKLSLSTSVLVSLTVFLLLIEEIIP SSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRTSATYHP-MAPWVKRLFLQRLPKLLC---MRG---- ------------------------------------------------------------------------ ------------------------------------------------------------------HTDRYH --------------------------CSESNMDSPKSRQKA------------------------------- ---------------------------------------------------------AEKRRRSSAKDDENA A-----------------------------------------------------VVAILERAAE-SVRYISG HIKKEHSIR-EVVEDWKFVAQVLDRIFLWLFLLVAILGSAMIFA--PSLRMWSSIIIKPNENDHN------- ------------------------------------- >Medaka_10_2/1-484 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------MKL TVFLLLLLSACPQLFAAITAPK---RFVSLAEMED-DLLKNLF-----QGYQRWVRP-IQRPND-TVRVRFG LKISQLVDVDEKNQLMTTNVWLRQEWIDYKLRWNP----DKYGGITS-IRVP--SE---NIWLPDIVLYE-- -NAD-GKF-EGSLMTKAIVKFNGAVTWMPPASYKSACTMDVTFFPFDRQNCSMKFGSWTYDGNMVDLVL--- -------------------------MDSQVDRKDFFDNGEWEILSATGAKGNRK---DGLYF--------YP F----ITCSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPS-DE-GEKLSLSTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSATYHP-MSPWVRSLFLQKLPRLLC---MRG---- ------------------------------------------------------------------------ ------------------------------------------------------------------HADRYH --------------------YPELAPESPALKSRSGGRRGIQRM---------------------------- ---------------------------------------------------------SSGGQQSTYDGKEEE A-----------------------------------------------------YSTMLEKAIY-SVRYISR HIRKDHFIR-EVVQDWKFVAQVLDRIFLWIFLSVSVLGTILIFT--PALQMFMKIPPPAPSEEPPINH---- ------------------------------------- >Fugu_14_1/1-487 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------MGTFPLRP RRLSFLIFLITLLLCSEFVSLA---------EMED-ALLRNLF-----QGYQRWVRP-IQHAND-TIKVRFG LKISQLVDVDEKNQLMTTNVWLCQEWIDFKLRWNP----DKYGGITS-IRVP--SE---NLWLPDIVLYE-- -NAD-GRF-EGSLMTKAIVRYNGAITWTPPASYKSACTMDVTFFPFDRQNCTMKFGSWTYDGTMVDLIL--- -------------------------IDKQVDRKDFFDNGEWEILSATGAKGNRK---DGLYS--------YP F----ITYSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPS-DE-GEKLSLSTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSATYHP-MSPWVRTLFLQKLPSLLC---MRG---- ------------------------------------------------------------------------ ------------------------------------------------------------------HTDRYH --------------------YPELGPESPEPKPRSGGRRGGQRISS-------------------------- ---------------------------------------------------------GGTYGQASSEGKDDE D-----------------------------------------------------WATMLDKAIF-SVRYISR HIRKEHFIR-EVVQDWKFVAQVLDRIFLWAFLTVSVLGTILIFT--PALQKFMQVLPQSSSEELPSNLPQ-- ------------------------------------- >Stickleback_IV_2/1-471 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M KWTVLFLLLVCPLSLAEIHAPS---EFVSLAEMED-ALMRNLF-----QGYQRWVRP-IQHAND-TVRVRFG LKISQLVDVDEKNQLMTTNVWLWQEWIDYKLRWNP----DKYGGITS-IRVP--SE---IIWLPDIVLYE-- -NAD-GRF-EGSLMTKAIVKFNGVITWTPPASYKSACTMDVTFFPFDRQNCTMKFGSWTYDGHMVDLVL--- -------------------------IDNQVDRRDFFDNGEWEILSATGARGTRK---DDMYT--------YP F----LTYSFILKRLPLFYTLFLIFPCLGLSFLTVLVFYLPS-DE-GEKLSLSTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSATYHP-MSPWVRNLFLQKLPRFLC---MRG---- ------------------------------------------------------------------------ ------------------------------------------------------------------HTDLYH --------------------YPELAPESPEMKPRSGGRKGGQRAN--------------------------- ---------------------------------------------------------SGARGQTASEGKEDE A-----------------------------------------------------WATMLDKAVY-SVRYISR HIRKEHFIR-EVVQDWKFVAQVLDRIFLWAFLTVSILGTVLIFT--PALYSFFKIP---------------- ------------------------------------- >Zebrafish_14_3_chrnb3b/1-462 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ MTLTVIGLFTLFTSIFATTPAR---EFVSLAERED-ALLRDLF-----QGYQRWVRP-ILHANH-TVKVRFG LKISQLVDVDEKNQLMTTNVWLYEEWLDYKLRWNP----ENYGGITF-IRVP--SE---SIWLPDIVLYE-- -NAD-GRF-EGSIMTKAIVRYNGLITWTPPASYKSACTMDVTFFPFDRQNCSMKFGSWTYDGNMVELVL--- -------------------------VNHQVDRSDFFDNGEWEILSATGHKGSRR---DGHYS--------YP Y----ITYSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPS-DE-GEKVSLSTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSATYHP-MSPWVRTLFLQRLPDLLC---MRG---- ------------------------------------------------------------------------ ------------------------------------------------------------------NTDRYH -------------------------------YPQMEPQSPDLK----------------------------- ---------------------------------------------------------PRSKKGPPGPEGDGQ A-----------------------------------------------------LINMLEQATN-SVRYISR HIKKEHFIR-EVVQDWKFVAQVLDRIFLWAFLTVSVLGTILIFT--PAVKMFLSTPPPPSP----------- ------------------------------------- >SpottedGar_LG4_2/1-458 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MKLMVALLCAALTVAAVSAFD---DFVSLAEMED-ALLKNLF-----RGYQKWVRP-VQHSND-TITVRFG LKISQLVDVDEKNQLMTTNVWLLQEWVDYKLRWNP----EDYGGITS-IRVP--SE---NIWLPDIVLYE-- -NAD-GRF-EGSLMTKVIVRSNGTILWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGNMVDLVL--- -------------------------VDDHVDRKDFFDNGEWEILNATGMKGNRK---DGMYA--------YP F----VTYSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPS-DE-GEKLSLSTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSATYHP-MSPWVKNLFLQRLPKLLC---MRG---- ------------------------------------------------------------------------ ------------------------------------------------------------------HTDRYH --------------------------YPEIDLNSPDVKPTT------------------------------- ---------------------------------------------------------TGKKRLLSEKEDENK A-----------------------------------------------------WLTLLEKATN-SVRYISS HIKKEHFIR-EVVQDWKFVAQVLDRIFLWVFLTVSVLGTILIFT--PALQMYLST----------------- ------------------------------------- >Zebrafish_1_2_chrnb3a/1-467 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MKLQI SGILLVAAVAYATIEAPEEFVS-------LAEMED-TLLRNLF-----RGYQKWVRP-VLHAND-TITVRFG LKISQLVDVDEKNQLMTTNVWLWEEWTDYKLRWNP----EDYGGITS-IRVP--SE---TIWLPDIVLYE-- -NAD-GRF-EGSLMTKAIVRFNGTIMWTPPASYKSACTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLTL--- -------------------------VDAYVDRKDFFDNGEWEILNATGQRGSRR---DGIYS--------YP Y----LTYSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPS-DE-GEKLSLSTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLLFIMIFVTFSIIVTVFVINVHHRSSATYHP-MAPWVKSLFLQRLPRLLC---MRG---- ------------------------------------------------------------------------ ------------------------------------------------------------------HTDRYQ --------------------------YPDIELRSPELKRGMKKGQQK------------------------- ---------------------------------------------------------SAGGGRAGVKEDENQ A-----------------------------------------------------WIALLEKATH-SVHYISR HIRKEHFIR-EVVQDWKFVAQVLDRIFLWAFLTVSVLGTILIFT--PALQMFFSTS---------------- ------------------------------------- >Medaka_1_2/1-472 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M KFAAWMLLCAALVLEQTAAQEV-QENVLSLAELED-SLLRNLF-----KGYQKWVRP-VQHAND-TITVRFG LKISQLVDVDEKNQLMTTNVWLWQEWIDVKLKWNP----DDYGGITS-IRVP--SE---TIWLPDIVLYE-- -NAD-GRF-EGSLMTKAIVRWDGTITWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGNMVDLVL--- -------------------------VDHYVDRKDFFDNGEWEILNATGQRGSRR---DEMYW--------YP F----LTYSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPS-DE-GEKLSLSTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLLFIMIFVTFSIIVTVFVINVHHRSSATYHP-MAPWVKSLFLQKLPRLLC---MRG---- ------------------------------------------------------------------------ ------------------------------------------------------------------HTDRYH ------------------------FPDIEMRSPELKTRRGAGRRAVPG------------------------ ---------------------------------------------------------GQQKGALGGMEDDSQ A-----------------------------------------------------WLAMLEKATN-SVHYISR HIRKEHFIR-EVVQDWKFVAQVLDRIFLWAFLTVSILGTVLIFT--PALQSYLSTP---------------- ------------------------------------- >Fugu_17_4/1-472 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------MG RMKFAVALLCVSLAAVRDAVQA-EEDFVSLAELED-SLLRNLF-----KGYQKWVRP-VQHAND-TITVRFG LKISQLVDVDEKNQLMTTNVWLWQEWIDVKLKWNP----DDYGGITA-IRVP--SE---TIWLPDIVLYE-- -NAD-GRF-EGSLMTKAIVRWDGTITWTPPASYKSACNMDVTFFPFDRQNCSMKFGSWTYDGNMVDLVL--- -------------------------VDHYVDRKDFFDNGEWEILNATGVKGSRR---DEVYW--------YP F----VTYSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPS-DE-GEKLSLSTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLLFIMIFVTFSIIVTVFVINVHHRSSATYHP-MAPWVKSLFLQRLPRLLC---MRG---- ------------------------------------------------------------------------ ------------------------------------------------------------------HTDRYN ------------------------FPDNEMRSPEPKPRRAIGRRGVQ------------------------- ---------------------------------------------------------GQQKGPLVGKEDENQ A-----------------------------------------------------WLAMLEKATN-SVRYISQ HIRKEHFIR-EVVQDWKFVAQVLDRIFLWAFLTVSILGTVLIFT--PALKMYVSTP---------------- ------------------------------------- >Stickleback_IX_2/1-447 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------QDDVVSLA---------EMED-SLLRNLF-----RGYQKWVRP-VLHSND-TITVCFG LKISQLVDVDEKNQLMTTNVWLWQEWVDLKLKWNP----DDYGGITS-IRVP--SE---TIWLPDIVLYE-- -NAD-GRF-EGSLMTKAIVRWDGTITWTPPASYKSACTMDVTFFPFDRQNCSMKFGSWTYDGNMVDLVL--- -------------------------VDHYVDRKDFFDNGEWEILNATGQRGSRR---DEVYW--------YP F----VTYSFILKRLPLFYTLFLIIPCLGLSFLTVLVFYLPS-DE-GEKLSLSTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLLFIMIFVTFSIIVTVFVINVHHRSSSTYHP-MAPWVKSLFLQRLPRLLC---MRG---- ------------------------------------------------------------------------ ------------------------------------------------------------------HTDRYH ------------------------FEDMEMHSPEVKTRRGVGRRGA-------------------------- ---------------------------------------------------------PGQRGPVSGKEEENR A-----------------------------------------------------WLAMLEKATS-SVRYISR HIKKEHFIR-EVVQDWKFVAQVLDRILLWAFLTVSILGTVLIFT--PALQMYFSTP---------------- ------------------------------------- >Coelacanth_scaffoldJH128121/1-438 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------LRRFSSIT---------ETED-ALLKNLF-----QGYQKWVRP-IKNLSS-IIQVKFG LKISQLVDVDEKNQLMTTNVWLKQEWTDYMLRWDP----DDYGGIKA-IRVP--SE---SLWLPDIVLYD-- -NAD-GRF-EGSLMIKAIVKYNGRVTWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGSMVDLIL--- -------------------------VDEHVDRKDFFDNGEWEILNATGTKGNRN---DGVYT--------YP F----ITYSFVLRRFPLFYTLFLIVPCLGLSFLTVMVFYLPS-DE-GEKLSLSTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSATYHP-MAPWVKRLFLEKLPKLLC---MKG---- ------------------------------------------------------------------------ ----------------------------------------------------------------HSECGTFS --------------------------DIDLDITSKTSL---------------------------------- ---------------------------------------------------------SGKHQMTSAKDKESK L-----------------------------------------------------LISFLEKATS-SIQYISR HIKKEQFIR-EVVEDWKFVAQVLDRIFLWLFLLVSVIGSGLIFT--PSLQLWMDG----------------- ------------------------------------- >WesternClawedFrog_1_2/1-460 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MILSAR FLSLSITVYFINSGFAKFHPLA---------EIED-ALLRKLF-----AGYQKWVRP-VLNPNS-TIKVNFG LKISQLVDVDEKKQLMTTNVWLRQEWMDMKLRWNP----KDYGGITY-IRVP--SE---SLWLPDIVLFE-- -NAD-GRF-EGSLMTKAIIKYDGTVTWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGNMVDLIL--- -------------------------LDENVDRKDFFDNGEWDILNATGLKGMRK---DGLYS--------YP F----ITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPS-DE-GEKLSLSTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSATYHP-MAPWVKRLFLEKLPKLLC---MKG---- ------------------------------------------------------------------------ ------------------------------------------------------------------HVDRFS ------------------------------FFDSESDVSSAKSK---------------------------- ---------------------------------------------------------PSGKRKNIHASDGEK V-----------------------------------------------------LIAFLEKAAD-SIKYIST HVKKEHFIR-QVVQDWKFVAQVLDRIFLWLFLSVSITGSVLIFT--PALQMWLNSHV--------------- ------------------------------------- >AnoleLizard_scaffoldGL343339_3/1-456 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MGLLD VITVSLLLCARSSAFTVFSSFA---------ENED-ALLRHLF-----RGYQKWIRP-VRHSND-TIKVYFG LKISQLVDVDEKNQLMTTNVWLKQEWIDNKLCWNP----EDYGGITA-IRVP--SE---SLWLPDIVLFE-- -NAD-GRF-EGSLMTKAIIKYNGIVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGNMVDLIL--- -------------------------VDENVDRTDFFDNGEWEILNAKGMKGNRK---DGLYS--------YP F----ITYSFVLRRLPLFYTLFLIVPCLGLSFLTVLVFYLPS-DE-GEKLSLSTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLLFIMIFVTLSIIVTIFVINVHHRSSSTYHP-MAPWVKRLFLQKLPRLLC---MKG---- ------------------------------------------------------------------------ ------------------------------------------------------------------HVDRFS ----------------------FSDPEGTLKQK--------------------------------------- ---------------------------------------------------------LARKHKHKHFKDGEK V-----------------------------------------------------VIAFLEKAAD-SIKYISR HVKKEHFIR-QVVQDWKFVAQVLDRIFLWLFLVVSVMGSVLIFT--PALKMWLHSGL--------------- ------------------------------------- >Chicken_Z_3/1-455 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MLCLMLCVLCWSRSDVAALGS-------VAENED-ALLRHLF-----QGYQKWVRP-VENSND-TIKVLFG LKISQLVDVDEKNQLMTTNVWLKQEWMDHKLSWNP----EEYGGITA-IRVP--SE---SLWLPDIVLFE-- -NAD-GRF-EGSLMTKAIVKYNGVVTWMPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGSMVDLIL--- -------------------------VDENVDRKDFFDNGEWEILNAKGMKGNRK---DGLYS--------YP F----VTYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPS-DE-GEKLSLSTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSATYHP-MAPWVKRLFLQKLPRLLC---MKG---- ------------------------------------------------------------------------ ------------------------------------------------------------------HVDRYS -------------------------------FSDTEEKETTLKSK--------------------------- ---------------------------------------------------------LPGKQKHKQAKDGEK V-----------------------------------------------------VIAFLEKAAD-SIRYISR HVKKEHFIR-QVVQDWKFVAQVLDRIFLWLFLVVSVTGSVLIFT--PALQMWLNSTL--------------- ------------------------------------- >Mouse_8_1/1-464 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------MTGFLRVFLA LSATLSGSWVTLTATAGLSSVA---------EHED-ALLRHLF-----QGYQKCVRP-VLNSSD-IIKVYFG LKISQLVDVDEKNQLMTTNVWLKQEWTDQKLRWNP----EDYGGINS-IKVP--SE---SLWLPDIVLFE-- -NAD-GRF-EGSLMTKAIVKSSGTVSWTPPASYKSSCTMDVTFFPFDKQNCSMKFGSWTYDGTMVDLIL--- -------------------------INENVDRKDFFDNGEWEILNAKGMKGNRR---EGFYS--------YP F----VTYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPS-DE-GEKLSLSTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHP-MAPWVKRLFLEKLPRWLC---MKD--P- ------------------------------------------------------------------------ --------------------------------------------------------------RDRFSFPDGT ----------------------ESKGTVRGKFPGKKKQTPT------------------------------- -------------------------------------------------------------------SDGER V-----------------------------------------------------LVAFLEKASE-SIRYISR HVKKEHFIS-QVVQDWKFVAQVLDRIFLWLFLTASVLGSVLIFI--PALKMWIHRFH--------------- ------------------------------------- >Human_8_2_CHRNB3/1-458 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -MLPDFMLVLIVLGIPSSATTG----FNSIAENED-ALLRHLF-----QGYQKWVRP-VLHSND-TIKVYFG LKISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNP----DDYGGIHS-IKVP--SE---SLWLPDIVLFE-- -NAD-GRF-EGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLIL--- -------------------------INENVDRKDFFDNGEWEILNAKGMKGNRR---DGVYS--------YP F----ITYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPS-DE-GEKLSLSTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHP-MAPWVKRLFLQKLPKLLC---MKD---- ------------------------------------------------------------------------ ------------------------------------------------------------------HVDRYS ------------------------SPEKEESQPVVKGK---------------------------------- ---------------------------------------------------------VLEKKKQKQLSDGEK V-----------------------------------------------------LVAFLEKAAD-SIRYISR HVKKEHFIS-QVVQDWKFVAQVLDRIFLWLFLIVSVTGSVLIFT--PALKMWLHSYH--------------- ------------------------------------- >Opossum_1_8/1-434 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------FSSIA---------ETED-ALLKKLF-----QGYQKWVRP-VLNAND-TIKVYFG LKISQLVDVDEKNQLMTTNVWLKQEWIDHKLRWNP----DEYGGINS-IKVP--SE---SLWLPDIVLFE-- -NAD-GRF-EGSLMTKVIVRHNGTIVWTPPSSYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLVL--- -------------------------IDENVDRKDFFDNGEWEILYAKGMKGNRR---EGLYS--------YP Y----VTYSFVLRRLPLFYTLFLIVPCLGLSFLTILVFYLPS-DE-GEKLSLSTSVLVSLTVFLLVIEEIIP SSSKVIPLIGEYLLFIMIFVTLSIIITVFVINVHHRSSSTYHP-MAPWVKRLFLQKLPKLLC---MRG--P- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------IDRYPFPDVVESQPEAKAK-------------------------------- ---------------------------------------------------------MPAKQRQKQMKDGEK I-----------------------------------------------------LVAFLEKAAE-SIRYISR HVKKEH----FINEDWKFVAQVLDRIFLWLFLLVSITGSVLIFT--PALQMWLSSYH--------------- ------------------------------------- >Amphioxus_scaffoldNW003101506_2/1-365 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------M---------------------------------------- --------------------------------------------------------------------SS-- -SAD-GKF-EVTSYTRAQVFYDGTVRWVPPAIYKSYCYIDVRFFPFDQQNCSMKFGTWTYDYTLVDMIP--- ------------------------WGDRKVNRDDFRETGEWVIIDAPVYRHVEN-Y-ECCPP--------YV D----VTAYLVIQRLPLFFTINLIVPCVLFSFISLFVFYLPS-R--GQKITLSISVLLSISVFLLVIFNTIP STSFAIPLIGKYLLFTATLVTLSIVATVFVLNVYHRSGST-HQ-MPPWVRMIFLQKLPTMLC---MRR--P- ------------------------------------------------------------------------ ----------------RSKGK-----------------------------------------DSDINGSQLE --------------------LEENKIATAIKYVKLRRLRMAGRRV--------------------------- ---------------------------------------------------------EEKEEDYAGYNTKTV E-----------------------------------------------------APEEAKPALE-GLEYVAS FLKRQDKCD-ALEEDWKYVAMIIDRIFLWMFVSACLVGTCSIFI--EPWMHDDIHGADD------------- ------------------------------------- >Amphioxus_scaffoldNW003101506_1/1-498 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------MLLYVLLATGFFVNVHLASGQG YGRMLLYVLLATGFFVNGCLGL---------EARE-KLYRDLF-----VKYNKVPRP-VKNVTD-KVTIKFG IAISQLIDVDEKNQVLTTSVWLRQEWFDYKLNWQP----EDYGNLTY-IRVP--ST---EIWVPDVVLYN-- -NAD-GSF-DVAAKTRAQVFHDGRVRWIPPAIYKSYCYIDVRFFPFDQQNCSMKFGTWTYDFTLVDMTV--- -------------------------WEDAMDRANFRESGEWIVIDAPIYRHVED-Y-ACCPP--------YV D----VTGYLVIQRLPLFFTVNLIVPCVLFSFISLFVFYLPS-NC-GEKITLSISVLLSLSVFLLVIFNTIP STSLAVPLIGKYLLFTVTMVATSITATVFVSNIYHRSGST-HD-MSEWVRIVFLRWLPGILC---MRR--P- ------------------------------------------------------------------------ --------------------------------------------------------------GDEASIEKDL ----------------HMSLPDLEETKLATALQYVKMRRMRARRQT-------------------------- ---------------------------------------------------------GEEQEEYKKCPVRTI E-----------------------------------------------------APEEARPALE-GLEYVTS FLKRQDKCD-ALEEDWNYIAMIIDRIFLWIFSVVCLLGTGCIFL--EPFVTENEATPA-------------- ------------------------------------- >Zebrafish_6_2_chrna4a/1-514 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------CCDEV---------QAEE-RLLNSLL-----SAYSKLTRP-VHSVSD-VVHVHFG LSIAQLID-DEKNQMMTTNVWVKQ------------------------MRIP--AQ---FIWKPDIVLYN-- -NAD-GDF-TVTHLTKAHLLHDGRVTWIPPAIYKSSCSIDVTFLPFDQQNCTIKFGSWTYDRSKIDLIR--- -------------------------IADSVDQLDYWESGEWLITSAVATYNVKK-Y-ECCSEE-------YA D----ITYSFIIRRLPLFYTINLIIPCLLILCLTVLVFYLPS-DC-GEEVTMCISVLLSLTVFLLLITEIIP PTSLVIPLIAEYLLFIMIFIILFIIITVFVLNVHHRSPDT-HS-MPQWVRRFFLDVMPRFIF---IQR--P- ---------------------------------------------------------------------QIW QKDAKGVCDDAQKSNKRCVDS---------------------------------------NWKNREIKEESI RMKVYSSCLNADMHSIKSPSQAYNNSTCPKMKLHKGRSQSVQVNCGERDVNLCNSSTR-------------- ---------------------------------------------------------FRSRSMQYCSLHEHE QQTSAVFNADKFSNICKVMTSTGEN-----------------------------PSHATRLAIE-GVQYIAE YLRAQHADL-SVKEEWKYVAMVIDRLFLWMFVLVCILGIVGLFI--PPWWAGMI------------------ ------------------------------------- >CionaSavignyi_reftig151/1-465 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------RNT RHLSLILLFISLWHLKIYTTSS---------QTEE-KLFKRLF-----DDYNIWIRP-VANSNQ-SVLIAFE LFVSQLVKVDEINQIMMTNLWLKQEWNDNKLRWRP----EDYGGVKY-LRVP--SE---FIWKPDIVLYN-- -TAV-GKF-QVDQNTKALLRYNGDVSWMPPAIFKSSCSIDVTYFPFDTQNCTMKFGSWTYDKARVNLVI--- -------------------------KGNEANRKEYWESGEWELLDVLGYRHERK-Y-NCCPEI-------YP D----VTYSFHIRRLPLFYMINLIIPCLLISFLTVLVFYLPS-DC-GEKITLCISVLLSLTVFLLVITEIIP STSLVIPLIGQYLLFTMIFVTLSIVITVFVLNVHFRSENT-HT-MPPWVRRVFLECLPKASC---FSH---- ------------------------------------------------------------------------ -----LFHSSISSHNHNNRPK--------------------------------------------------- ----------------------IRKRAINKLAKNLVNFDK-------------------------------- ---------------------------------------------------------KLDTQVFNDAGEYKI S--------------------------------------------------------EVQRAIE-SVMYIAN HLKVEDEST-EIENDWKYVGMVIDRIFLWIFIVVCVLGTTGIFL--RPLLDDT------------------- ------------------------------------- >CionaIntestinalis_scaffoldHT000143/1-486 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------MV CSISFIPIISLTLLRLLFCTAS---------RHEE-DLYKILF-----DDYNIWIRP-VAQSNQ-SVLIKFE LFVSQLVKVDEINQIMMTNLWLKQEWNDNKLRWKP----NDYGGVEY-LRIP--SE---NIWKPDIVLYN-- -TAV-GKF-QVDQNTKALLKYNGDISWMPPAIFKSSCSIDVTYFPFDTQNCTMKFGSWTYDKARVNLVM--- -------------------------KGKEANRKEYWESGEWEVLGVFGYRHERK-Y-NCCPEV-------YP D----VTYSFHIRRLPLFYMINLIIPCLLISFLTVLVFYLPS-DC-GEKITLCISVLLSLTVFLLVITEIIP STSLVIPLIGQYLLFTMIFVTLSIVITVFVLNVHYRSENT-HT-MPPWIRRVFLECLPKVMF---MKR--P- ------------------------------------------------------------------------ -------------KKRKRAVY-----------------------------------------KLAKNLVNFT ---------------------PVEKLDTHVFDENGDYKIAFFGQ---------------------------- ---------------------------------------------------------DSNRKAQTQASNTDN N-----------------------------------------------------LPKEVKRAIE-SVIYIAN HLKVDDEST-EIENDWKYVGMVIDRIFLWIFIVVCILGTTGLFL--RPLLDDEHVSSAHAHEDK-------- ------------------------------------- >WesternClawedFrog_1_3/1-448 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MYRFLR NEKSFCFLLLTLLAVLKGSLQC---------ETEE-KLFQKLL-----ARYNQHIRP-VENVSD-PVMVHFE VAITQLVNVDEVNQILETNLWLRHIWNDYKLQWNP----KEYDGIEF-MRIP--AD---KIWKPDIVLYN-- -NAV-GDF-QVEGKSKALVKYNGLITWSPPAIFKSSCPMDITFFPFDHQNCSMKFGSWSYDKAKIDLAI--- -------------------------IGSKVDMKDFWENSEWEIVDASGFKHDIK-Y-NCCEEI-------YT D----ITYSFYIRRLPMFYTINLIMPCLFLSFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTT-HK-MPMWVKDVFLKRLPKLLM---MKK---- ------------------------------------------------------------------------ ---------TVEKKNRPCSKR-----------------------------------------NRKKSCEKSS --------------------ELVDSESAEVEQFEDESCYHCMRSKEQSS----------------------- ---------------------------------------------------------RVRRRQQRDSNGAVQ E-----------------------------------------------------CSSELTEVVD-SIQFMAG NIRDHNERK-E------------------------------------------------------------- ------------------------------------- >AnoleLizard_scaffoldGL343339_2/1-497 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------MMLSQKWLGV LYFTFYLWANISLFFRQGCLAC---------KSEE-RLFHKLF-----TRYNQHIRP-VENVSD-PVTVYFE LAITQLANVDEVNQIMETNLWLRHIWNDYKLRWNP----IEYEGIEF-IRVP--AD---KIWKPDIVLYN-- -NAV-GDF-QVEGRTKALLKYDGTIAWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAKIDLLI--- -------------------------IGSKVDMNDFWENSEWEIIDASGYKHDIK-Y-NCCEEI-------YT D----ITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTT-HS-MPKWVRTVFLSLLPKVLM---MKR--P- ------------------------------------------------------------------------ ------IQKHVETQPKKPKKA-----------------------------------------GEQKATKASK ---------------------EKADDLGEVKVLDEHRCCHCDKLS--------------------------- ---------------------------------------------------------EPATGKKRRSSQSAK W-------------VAEQMD----------------------------------YSPEVKQVIT-SVQLIAE NMRSQNKTK-EVEDDWKYVAMVIDRVFLWVFIILCVFGTGGLFL--QPLIADT------------------- ------------------------------------- >Chicken_Z_2/1-494 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------MHPKRRLCW CLPASGAWAFMLTSLIADTTAC---------ESEE-RLFHKLF-----SRYNQFIRP-VENVSD-PVTVHFE LAITQLTNVDEVNQIMETNLWLRHIWNDYKLRWDP----REYDGIEF-VRVP--AD---KIWKPDIVLYN-- -NAV-GDF-QVEGKTKALLRYDGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAKIDLLI--- -------------------------IGSKVDMNEFWENSEWEIVDASGYKHDIK-Y-NCCEEI-------YT D----ITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLVGEYLLFTMIFVTLSIVITVFVLNIHYRTPTT-HT-MPKWVKTVFLSLLPKVLL---MQR--P- ------------------------------------------------------------------------ -------LEQEKKNISKKTKK-----------------------------------------GSAKTSGKSK -----------------------HSKHKDNKLHKEQRCCHCDKADDLTSTRR-------------------- ---------------------------------------------------------SQLSHQSLKWMAEHT E-----------------------------------------------------YSPEVKDVIN-NVQFIAE NMKSQNETK-EVEDDWKYVAMVIDRVFLWVFIILCVFGTAGLFI--QPLIADT------------------- ------------------------------------- >Mouse_8_2/1-494 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------MLNSRDQGN LHSGLCLWLCGFLALFKGSTGC---------ESEE-QLFHRLF-----AHYNRFIRP-VENVSD-PVTVHFE LAITQLANVDEVNQIMETNLWLRHIWKDYRLRWDP----TEYDGIET-LRVP--AD---NIWKPDIVLYN-- -NAV-GDF-QVEGKTKALLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLI--- -------------------------IGSKVDMNDFWENSEWEIVDASGYKHDIK-Y-NCCEEI-------YT D----ITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPAT-HT-MPKWVKTIFLQAFPSILM---MRK--P- ------------------------------------------------------------------------ ------LDKTKEAGGVKDPKS-----------------------------------------HTKRPAKVKF ----------------------THRGESKLLKECHHCQKSSDIAPGK------------------------- ---------------------------------------------------------RRSSQQPARWVAENS E-----------------------------------------------------HSSDVEDVIE-SVQFIAE NMKSHNETN-EVEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFL--QPLLGNTGKS---------------- ------------------------------------- >Human_8_3_CHRNA6/1-494 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------MLTSKGQGF LHGGLCLWLCVFTPFFKGCVGC---------ATEE-RLFHKLF-----SHYNQFIRP-VENVSD-PVTVHFE VAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDP----MEYDGIET-LRVP--AD---KIWKPDIVLYN-- -NAV-GDF-QVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLI--- -------------------------IGSKVDMNDFWENSEWEIIDASGYKHDIK-Y-NCCEEI-------YT D----ITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTT-HT-MPRWVKTVFLKLLPQVLL---MRW--P- ------------------------------------------------------------------------ --LDKTRGTGSDAVPRGLARR-----------------------------------------PAKGKLASHG -----------------------EPRHLKECFHCHKSNELATSK---------------------------- ---------------------------------------------------------RRLSHQPLQWVVENS E-----------------------------------------------------HSPEVEDVIN-SVQFIAE NMKSHNETK-EVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFL--QPLLGNTGKS---------------- ------------------------------------- >Opossum_1_5/1-496 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------MLMETWQMR LHSGPYLWLCLFISFFKGYAAC---------ESEE-RLFHKLF-----SHYNQFIRP-VENVSD-PVTVHFE VAITQLANVDEVNQIMETNLWLRHIWNDYKLRWNP----AEYDGIEL-LRVP--AD---KIWKPDIVLYN-- -NAV-GDF-QVEGKTKALLKYDGMISWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAKIDLLI--- -------------------------IGSKVDMNDFWENSEWEIVDASGYKHDIK-Y-NCCEEI-------YT D----ITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTT-HT-MPKWVKTVFLQMLPKILM---MRR--P- ------------------------------------------------------------------------ -------LEKQREKRSDKNSE-----------------------------------------EFARKPAKIK ----------------------FAECRDPKLFEEQECCHCNKSNELATSK---------------------- ---------------------------------------------------------KRLSYQSLKWMTEHL E-----------------------------------------------------YSSEVKDVID-SVQFIAE NMRNQNETK-EVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFL--QPLIGNTVKS---------------- ------------------------------------- >AustralianGhostshark_scaffoldNW006890058_2/1-506 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M AHSIEDATQIIESLTHVWVVTS---------EAEQ-RLLTKLF-----ENYSRYTRP-VENVSE-AVTVYFE VSMSQLVKVDEVNQIMETNLWLKHIWDDYKLRWDP----AEFGGVES-IRVP--CG---KIWKPDIVLYN-- -NAV-GDF-QVEDKTRALLKFNGTVTWKPPAIFKSSCRMDVTYFPFDYQNCSIKFGSWTYDKAKIDLAL--- -------------------------IGSTINLDNLWENGEWVIMDASGFKHDIK-Y-NCCEEV-------YA D----ITYSLYIRRLPLFYTVNMIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITEIIP STSLVIPLIGEYLLFTMIFIILSIVITVFVLNVHYRTPKT-HT-MPSWVRTIFVELLPRVMF---MVR--P- ----------------------------------------------------------------------TK DWEAEKPQQIRYPDCTELFNL-----------------------------------------NSLSSSSEAK --------------------------CSKVSSLGQDSRCNCYRRHMARN----------------------- ---------------------------------------------------------PDAGGSVISACSPDF L-------------DSLLAIS---------------------------------VCPEIQQTIE-NVKYVAE NIKLQNQCN-EVEDDWKYVAMVIDRICLWLFILVCVSGTVGLFL--QPLMLGAENTIAETSGG--------- ------------------------------------- >WesternClawedFrog_3_1/1-468 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------FFCS---------NVEH-RLYEDLL-----KSYNPYIRP-VMNVSD-PVILHFE VSMSQLVKVDEVNQIMETNLWLRHLWNDYKLKWNP----SDYGGIEF-LRIP--AS---QIWRPDIVLYN-- -NAV-GAF-HVDDKAKAVVRYSGDVTWIPPAIFKSSCKIDVTFFPFDYQNCSLKFGSWTYDKAKINLVM--- -------------------------IGSKINLKEFWESGEWVIINAPGYKHEIK-Y-NCCVEI-------YQ D----ITYSLYIRRLPLFYTIYIIIPCLLISCLTILVFYLPS-DC-GEKVTLCMSVLLSLTVFLLVITEIIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPKT-HT-MPHWVKRFFLHLLPKVMF---MTR--P- ------------------------------------------------------------------------ ---EKQPYALKPQAYLDISSS-----------------------------------------EIRSCQDQLF -----------------YQDSSCACGQLKRLYTSDTACNVTRG----------------------------- ---------------------------------------------------------SSLESMYNLGLHSGS G-----------------------------------------------------LSPEIREAIE-DVHFIAE NMKAQDEAK-EVQDDWKYVAMVIDRIFLWVFVLVCILGTAGLFL--QPLLFSD------------------- ------------------------------------- >AustralianGhostshark_scaffoldNW006890074_3/1-470 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------CYSS---------KGED-RLFKIMF-----SRFTKYIRP-VENVSN-PVMVQFE VSMSQLVKVDEVNQILETNLWLRHIWNDYKLRWNP----VDFDGIEQ-IRVP--SD---KIWKPDIVLYN-- -NAV-GDF-QVEDKTKALLKYDGTVTWIPPAIFKSSCPMDITYFPFDYQNCSMKFGSWSYDKAKIDLII--- -------------------------IGSKVNLKDFWESGEWEIIDAPGYKHDIK-Y-NCCEEI-------YT D----ITYSFYIRRLPLFYSVNLIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTT-HT-MPGWVRKIFLHFLPRVML---MRR--P- ------------------------------------------------------------------------ ---LGEKQPEKSRGARRKANC------------------------------------------PKTDTTNYL -------------------------EYGDFKIPKEQPICSCRHPKESCE----------------------- ---------------------------------------------------------SVPCSLSRQVSPQSL N-------------ALFAFSV---------------------------------LSPEVHQAID-CVKYIAE NMKSQNEAK-EVEDDWKYVAMVIDRIFLWVFVLVCILGTAGLFL--QPLMA--------------------- ------------------------------------- >Medaka_10_3/1-594 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------MLRLTNHCSRSMARIRCQSTSFTHRRQRKATGTDAQSH FTGRAFAVLLLVLLAAHECFSS---------KSED-RLFRRLF-----RRYNQFIRP-VENVSD-PVTVEFE VSISQLVKVDEVNQIMETNLWLRHVWNDYKLKWTP----AEYDGIEF-IRVP--SN---RIWRPDIVLYN-- -NAV-GDF-LVADKTKALLKFDGTITWVPPAIFKSSCPMDITYFPFDYQNCSMKFGSWTYDKAKIDLVL--- -------------------------IGSKVNLKDFWESGEWEIIDAPGYKHDIK-Y-NCCEEI-------YT D----ITYSFYIRRLPLFYTINLIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPMT-HT-MPDWVRSVFLGLLPRVML---MRR--P- --------------------------------------------------------------IDQSCSSPAR CTGGTTRAGITGGSKKRKNSV-----------------------------------------GGGSSSGSVS IGGITGGVACAALDSGSGGGGASSAGGSMNCVEYGDINRDMTRRCPYRGKEVPTPVPPPRVP---------- ---------------------------------------------------------SPQAPQPPGPPESEL PKVSRPLKASSPVNAVVAFSV---------------------------------VSPEVKQAIE-SVKYIAE NLRTRNKAK-EVEDDWKYVAMVIDRIFLWVFVTVCVLGTVGLFF--QPLISFFK------------------ ------------------------------------- >Stickleback_IV_3/1-561 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------CFSS---------KGED-RLFRRLF-----RRYNQFIRP-VENVSD-PVTVEFE VSMSQLVKVDEVNQIMETNLWLRHVWNDYKLKWAP----VEYDGIEF-IRVP--SN---KIWRPDIVLYN-- -NAV-GDF-LVEDKTKALLRFDGTITWIPPAIFKSSCPMDITYFPFDYQNCSMKFGSWTYDKAKIDLVL--- -------------------------IGSKVNLKDFWESGEWEIIDAPGYKHDIK-Y-NCCEEI-------YP D----ITYSFYIRRLPLFYTINLIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPMT-HT-MPEWVRSVFLGVLPRVML---MRR--P- --------------------------------------------------------------IDQGCTSPGG ATGVAGRGRKSAGNRKRKNSI-------------------------------GGGSGTGSGSGSVSIGGITG GVACPPLEAGAAGGGGGGGGAAASAGGSMNCVEYGERNRNMNRRCPYRGKEVPTPVPPSMVPPPPPPPPPPP PPPPP----------------------------------------------------SQHAPPTQGPQESDL PKAPRPLNVPSPVNAVVAFSV---------------------------------VSPEIKQAIE-SVRYIAE NMRTRNKAK-EVEDDWKYVAMVIDRIFLWVFVTVCVLGTVGLFL--QPLISF-------------------- ------------------------------------- >Fugu_14_3/1-546 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------CASS---------KSED-RLFRRLF-----RRYNQFIRP-VENVSD-PVTVEFE VSISQLVKVDAVNQIMETNLWLRHVWNDYKLRWVP----VEYDGIEY-IRVP--SN---KIWRPDIVLYN-- -NAV-GDF-LVEDKTKALLKYDGTITWLPPAIFKSSCPMDITYFPFDYQNCSMKFGSWTYDKAKIDLVL--- -------------------------IGSKVNLKDFWESGEWEIIDAPGYKHDIK-Y-NCCEEI-------YT D----ITYSFYIRRLPLFYTINLIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPMT-HT-MPEWVKAVFLGVLPRVML---MRR--P- --------------------------------------------------------------IDQSCAYPTR VPGVTGAGGSIVGNKKRKSSI-----------------------------------------GGGSSSGSVS VGGITGGVACPSLDGAAGGGGATSSGSSMNCVEYGTMNHDMKRDMNRRFPYRGKEVPTPVPPPKVPPPPPPP ---------------------------------------------------------PAQATPNPGPQESEL PKLPRSLNAPSPVNAVVAFSV---------------------------------VSPEVKQAIE-SVKYIAE NMRTRNKAK-EVEDDWKYVAMVIDRIFLWVFVTVCVLGTLGLFL--QPLMNF-------------------- ------------------------------------- >Zebrafish_1_3_chrna6/1-512 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------MN SAGRVTLFFLLIALITQDCFSS---------KGED-RLFRRLF-----RRYNQFIRP-VENVSD-PVTVEFE VSISQLVKVDEVNQIMETNLWLRHIWNDYKLKWSP----AEFDGIEF-IRVP--SN---KIWRPDIVLYN-- -NAV-GDF-LVEDKTKALLKFDGTITWVPPAIFKSSCPMDITYFPFDYQNCSMKFGSWTYDKAKIDLVL--- -------------------------IGSKVNLKDFWESGEWEIIDAPGYKHDIK-Y-NCCEEI-------YP D----ITYSFYIRRLPLFYTINLIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPMT-HT-MPSWVRTVFLRALPRIML---MRR--P- ------------------------------------------------------------------------ -LDLSESSGKGGLETGGSSGT-----------------------------------------GAGRGGEGKK ---------RKNSGSQQGAMNSLEFGEGKAALEGKKGGCPCHPLKEATE----------------------- ---------------------------------------------------------GDCGKVSRQLSPQAI N-------------TVVAFSV---------------------------------VSPEIKQAIE-SVKYIAE NMRSRNKAK-EVEDDWKYVAMVIDRIFLWVFVLVCVLGTLGLFL--QPLIGFLS------------------ ------------------------------------- >SpottedGar_LG4_3/1-490 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------MN SAGRVTLFFLLIALITQDCFSS---------KGED-RLFRRLF-----RRYNQFIRP-VENVSD-PVTVEFE VSISQLVKVDEVNQIMETNLWLRHIWNDYKLKWIP----AEFDGIEY-IRVP--SN---KIWRPDIVLYN-- -NAV-GDF-LVEDKTKALLKYDGTVTWVPPAIFKSSCPMDITYFPFDYQNCSMKFGSWTYDKAKIDLVL--- -------------------------IGSKVNLKDFWESGEWEIIDAPGYKHDIK-Y-NCCEEI-------YP D----ITYSFYIRRLPLFYTINLIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPMT-HT-MPVWVRSIFLGVLPRIMF---MRR--P- ------------------------------------------------------------------------ --LDPQTPKGGSKKRKNSASQ-----------------------------------------QGAMNCLEYG ----------------------------ENKLPKDQKKCLCQHPKEPSE----------------------- ---------------------------------------------------------PDTSKLSRQLSPQSI N-------------TVLAFSV---------------------------------VSPEIKQAIE-SVKYIAE NMRSRNKAK-EVEDDWKYVAMVIDRIFLWVFVLVCVLGTLGLFL--QPLIGF-------------------- ------------------------------------- >Medaka_1_6/1-526 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------MR QTAEWTALLLLLALNARDCFSS---------KAED-RLFRKLF-----RRYNQFIRP-VENVSD-PVTVEFE VSISQLVKVDEVNQIMETNLWLRHIWNDYKLRWTP----AEFDGIEF-IRVP--SN---KIWRPDIVLYN-- -NAV-GDF-LVEDKTKALLKFDGTITWVPPAIFKSSCPMDITYFPFDYQNCSMKFGSWTYDKAKIDLVL--- -------------------------IGSKVNLKDFWESGEWEIIDAPGYKHDIK-Y-NCCEEI-------YP D----ITYSFYIRRLPLFYTINLIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPMT-HT-MPGWVHLVFLKVLPRIML---MRR--P- -----------------------------------------------------------------------T DEDGKAGGLDTSGEAGGAGGG-----------------------------------------GGGGGGGGGK GGKRPKNSLMQQVGGGSLNCLEYGDCKLSSMDGCGAKKCPCPCQHGRETPET-------------------- ---------------------------------------------------------AASVRMKHQLSQQSI N-------------TVVAFSV---------------------------------VSPEVKQAIE-SVKYIAE NMRSRNKAK-EVEDDWKYVAMVIDRIFLWVFVTVCLLGTMGLFL--QPLISFLS------------------ ------------------------------------- >Fugu_17_3/1-513 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------------MR SAVRWILL-LPLALMVQGCFSS---------KAED-RLFRRLF-----RKYNQFIRP-VENVSD-PVTVEFE VSISQLVKVDEVNQIMETNLWLRHIWNDYKLRWIP----TEFDGIEF-IRVP--SN---KIWRPDIVLYN-- -NAV-GDF-LVEDKTKALLKFDGTITWVPPAIFKSSCPMDITYFPFDYQNCSMKFGSWTYDKAKIDLVL--- -------------------------IGSKVNLKDFWESGEWEIIDAPGYKHDIK-Y-NCCEEI-------YT D----ITYSFYIRRLPLFYTINLIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPMT-HT-MPGWVRSVFLKVLPRIML---MRR--P- ------------------------------------------------------------------------ -----IDDNSEARGVDSSGEA-----------------------------------------GGAGGGGGGG KGGKRRKNSLMQVAGGSLNCLEFGDSKLSSMEDGAGKRCPCPCRHE-------------------------- ---------------------------------------------------------KDTPGTPDLGKVQSV N-------------TVVAFSV---------------------------------VSPEIRQAIE-SIKYIAE NMRSRNKAR-EVEDDWKYVAMVIDRIFLWVFVTVCVLGTVGLFL--QPLCGFVS------------------ ------------------------------------- >Stickleback_IX_3/1-503 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------CCSS---------KAED-RLFRKLF-----RRYNQFIRP-VENVSD-PVTVEFE VSISQLVKVDEVNQIMETNLWLRHVWNDYKLRWMP----VEFDGIEF-IRVP--SN---KIWRPDIVLYN-- -NAV-GDF-LVEDKTKALLKFDGTITWVPPAIFKSSCPMDITYFPFDYQNCSMKFGSWTYDKAKIDLVL--- -------------------------IGSKVNLKDFWESGEWEIIDAPGYKHDIK-Y-NCCEEI-------YP D----ITYSFYIRRLPLFYTINLIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPMT-HT-MPDWVRSVFLKVLPKIML---MRR--P- ------------------------------------------------------------------------ --IDDDSKPGGLDISRESGGA-----------------------------------------GGGGGGGGGG KGGKRQKNSLMQVRGGSLNCLEFGDSKFSSAEGCTGKKCPCPCQHGKETPET-------------------- ---------------------------------------------------------PDLGKITRQLSHQSI N-------------TVVAFSV---------------------------------VSPEIKQAIE-SVKYIAE NMRSRNKAK-EVEDDWKYVAMVIDRIFLWVFVTVCILGTVGLFL--QPLIGFFS------------------ ------------------------------------- >SpottedGar_LG3_3/1-533 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------MKT KCFVFLLTFSYIVFLLSGGTCS---------EAEH-RLFSVIF-----ANYNQYIRP-VENVSD-PVIVQFE VSMSQLVKVDEVNQIMETNLWLRHIWNDYKLKWDP----SEFGGVEF-IRVP--SN---KIWKPDIVLYN-- -NAV-GDF-QVDDKTKALLHYNGDVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWTYDKAKIDLVL--- -------------------------IGSTINLKDFWESGEWVIIDAPGYKHDIK-Y-NCCEEI-------YP D----ITYSLYIRRLPLFYTINMIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPKT-HT-MPQWVRTVFLGILPRVMF---MTR--P- ------------------------------------------------------------------------ EREPEKTSQYLPPQPYPHTHS-----------------------------------------QQKQQNSNAP HHRHRIFISTELSNLNNLAGTGDSKCSTKDGFLCQEGRCNCCWRQRTTKLPADGGL---------------- ---------------------------------------------------------GGGSGDIGSSYSSSE S-----------LDALLSVSA---------------------------------LSPEVRDAIE-SVRYIAE NMRLQNEAK-EIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFL--QPLLIGEDS----------------- ------------------------------------- >Zebrafish_18_3_chrna3/1-477 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------VCCSE----------AEH-RLFSVIF-----SSYNQYIRP-VENVSD-PVVVQFE VSMSQLVKVDEVNQIMETNLWLRHIWNDYKLRWDP----KDFGGVEF-IRVP--SN---KIWKPDIVLYN-- -NAV-GDF-QVDDKTKALLRFNGDVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWTYDKAKIDLVL--- -------------------------IGSTINLKDFWESGEWTIIDAPGYKHDIK-Y-NCCEEI-------YT D----ITYSLYIRRLPLFYTINMIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPKT-HT-MPCWVRRVFLSLLPRVMF---MTR--P- ------------------------------------------------------------------------ --EKDQEVPAKHKQTSVCRGP-----------------------------------------QLLLCPTELN -------------------------EASRTAFLCREHHCWKKHISNMTSE---------------------- ---------------------------------------------------------GAEDGGSPCSSSESL D-------------GFLCMSA---------------------------------VSPQVREAIE-SVKYIAE NMRLQNEAK-EVQDDWKYVAMVIDRIFLWVFVLVCILGTAGLFL--QPLLLGEDM----------------- ------------------------------------- >Medaka_3_3/1-560 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------MTA RICFRFPVMLFLLYLLSGGTCS---------EAEH-KLFSVIF-----SNYNQYIRP-VENVSD-PVIVQFE VSMSQLVKVDEVNQIMETNLWLRHIWNDYKLKWNP----KEFGGVEF-IRVP--SN---RIWKPDIVLYN-- -NAV-GDF-QVDDKTKALLRFNGDVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWTYDKAKIDLVL--- -------------------------IGSTINLKDFWESGEWTIIDAPGYKHDIK-Y-NCCEEI-------YT D----ITYSLYIRRLPLFYTINMIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPKT-HT-MPCWVRRVFLGLLPRVMF---MTR--P- ---------------------------------------------------------------------ERD PEKVAVGSSVQTVHLRPCTVH--------------------------------SSGTLQKHKARAPGSSMMS SLTNRQRILNNTELSNLNNRSGDSNRCASSGFPGSGERCNCCWQKRSGKLPYDSEGGSGG------------ ---------------------------------------------------------LGCLGALSGGGAMGI GGETQFSSSESLDGRIMSLLP---------------------------------LSPEIREAIE-SVKYIAE NMRLQNDAK-EVQDDWKYVAMVIDRIFLWVFVLVCILGTAGLFL--QPLLLWDDI----------------- ------------------------------------- >Fugu_13_1/1-538 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------MSRRGCCS---------EAEH-KLFSVIF-----SNYNQYIRP-VENVTD-PVIVQFE VSMSQLVKVDEVNQIMETNLWLRHIWNDYKLRWNP----KEYGGVEY-IRVP--SS---RIWKPDIVLYN-- -NAV-GDF-QVDDKTKALLRYNGDVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWTYDKAKIDLVL--- -------------------------IGSTMNLKDFWETGDWLIIDAPGYKHDIK-Y-NCCEEI-------YT D----ITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPKT-HT-MPCWVRAVFLELLPRVMF---MTR--P- ---------------------------------------------------------------------ERE PEQDTGAGNVQDMHSRSCAVH------------------------------------SATLHKPQALASGVV SSISNRQYLFNNTELSNLNNLSGDPSKGSTSLCCEGRCNCCWYQRSSKLPADSGGGSGGMGSLGALTGGSVA ---------------------------------------------------------KVSGGSQRSSSESLN G-------------GLMPLLP---------------------------------LSPEVREAIE-SVRYIAE NMRLQNEAK-EVQDDWKYVAMVIDRIFLWVFVLVCILGTAGLFL--QPLLLAEDI----------------- ------------------------------------- >Stickleback_II_2/1-540 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------CSCS---------DAEH-KLFSVIF-----SSYNQYIRP-VENVTD-PVVVQFE VSMSQLVKVDEVNQIMETNLWLRHIWNDYKLRWNP----KDFGGVDF-IRVP--SN---RIWKPDIVLYN-- -NAV-GDF-QVDDKTKALLRFNGDVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWTYDKAKIDLVL--- -------------------------IGSTINLKDFWESGEWTIIDAPGYKHDIK-Y-NCCEEI-------YT D----ITYSLYIRRLPLFYTINMIIPCLLISFLTVLVFYLPS-DC-GEKITLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPKT-HT-MPCWVRTVFLGLLPRVMF---MTR--P- --------------------------------------------------------ETDAERVLAAAGDVQT THLRPCAIHPSGALQKQHKPQ-----------------------------------------APPPPSVVSS LTNRQRLFNNTELSDLNNLSGDPAKGAGSALLCCKGHCNCCWRQRSSKLPADSGGGS--------------- ---------------------------------------------------------GGLGSMGALSGGSAV GGGSHCSSSESVAGGTMSMLP---------------------------------LSPEVQEAIE-SVKYIAE NMRLQNEAK-EVQDDWKYVAMVIDRIFLWVFVLVCILGTAGLFL--QPLLLWDDI----------------- ------------------------------------- >Coelacanth_scaffoldJH127300_2/1-496 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M KNNREPFLFALFSLLFYDCNSS---------EDEH-KLFEDLF-----KNYSCYIRP-VENISD-PVIVQFE VSMSQLVKVDEVNQIMETNLWLKHIWNDYKLKWKP----EEYGGVQS-IRVP--ST---DIWKPDIVLYN-- -NAV-GEF-QVDDKTKALLKYNGDVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWTYDKAKIDLVL--- -------------------------IGSNINLKDFWESGEWKIINAPGYKHDIK-Y-NCCEEI-------YT D----ITYSLHIKRLPLFYTINMIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPKT-HT-MPAWVKTTFLNLLPRIMF---MKR--P- ------------------------------------------------------------------------ ------VRETDKNCKSKSLHT-----------------------------------------TDLTNLNSFS ---------------------TSETKCSKDSFVCQDTRCNCCRHLKMKIS---------------------- ---------------------------------------------------------DISGNLTRSSSTESL D-------------DLLAISK---------------------------------LSPEMTEAIE-SIRYIAE NMKLQNEAK-EVQNDWKYVAMVIDRIFLWVFILVCILGTAGLFL--QPLMVGDDL----------------- ------------------------------------- >Opossum_1_3/1-499 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------------MAA GGVGLGSLLAGLAFLFTGTEGF---------NAEH-RLFDRLF-----EDYNEIIRP-VANVSD-PVIIHFE VSMSQLVKVDEVNQIMETNLWLKHIWNDYKLKWNP----ADYEGVEF-MRVP--SQ---KIWKPDIVLYN-- -NAV-GDF-QVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVM--- -------------------------IGSSMNLKDYWESGEWAIINAPGYKHDIK-Y-NCCEEI-------YI D----ITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPKT-HT-MPQWVKTIFLDWLPKIMF---MAR--P- ------------------------------------------------------------------------ ------ASSSEEASQRSRPFS-----------------------------------------GAELSNLNCF --------------------RGSETKCCKGGSACQDGTCGVCRHQRLKLS---------------------- ---------------------------------------------------------NLSTNLPRSSSSESV D-------------ALLSYSV---------------------------------LSPEMKEAIE-SVKYIAE NMKAQNEAK-EIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFL--QPLMTGDEI----------------- ------------------------------------- >Mouse_9_2/1-504 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------------------------------------------------------MRSSDMGVV LPPPPLSMLMLVLMLLPVASAS---------EAEH-RLFQYLF-----EDYNEIIRP-VANVSH-PVIIQFE VSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKP----SDYQGVEF-MRVP--AE---KIWKPDIVLYN-- -NAD-GDF-QVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVL--- -------------------------IGSSMNLKDYWESGEWAIIKAPGYKHEIK-Y-NCCEEI-------YQ D----ITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTT-HT-MPTWVKAVFLNLLPRVMF---MTR--P- ------------------------------------------------------------------------ -------TSTEEDAPKTRNFY-----------------------------------------GAELSNLNCF --------------------SRADSKSCKEGYPCQDGTCGYCHHRRVKIS---------------------- ---------------------------------------------------------NFSANLTRSSSSESV D-------------AVLSLSA---------------------------------LSPEIKEAIQ-SVKYIAE NMKAQNVAK-EIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFL--QPLMARDDT----------------- ------------------------------------- >Human_15_3_CHRNA3/1-505 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------MGSGPLSLPL ALSPPRLLLLLLLSLLPVARAS---------EAEH-RLFERLF-----EDYNEIIRP-VANVSD-PVIIHFE VSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNP----SDYGGAEF-MRVP--AQ---KIWKPDIVLYN-- -NAV-GDF-QVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVL--- -------------------------IGSSMNLKDYWESGEWAIIKAPGYKHDIK-Y-NCCEEI-------YP D----ITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTT-HT-MPSWVKTVFLNLLPRVMF---MTR--P- ------------------------------------------------------------------------ -------TSNEGNAQKPRPLY-----------------------------------------GAELSNLNCF --------------------SRAESKGCKEGYPCQDGMCGYCHHRRIKIS---------------------- ---------------------------------------------------------NFSANLTRSSSSESV D-------------AVLSLSA---------------------------------LSPEIKEAIQ-SVKYIAE NMKAQNEAK-EIQDDWKYVAMVIDRIFLWVFTLVCILGTAGLFL--QPLMAREDA----------------- ------------------------------------- >Chicken_10_3/1-496 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M QSIHALLLTAAVCILFQGCGGS---------EPEH-RLYAALF-----KNYNQFVRP-VKNASD-PVIIQFE VSMSQLVKVDEVNQIMETNLWLKHIWNDYKLRWNP----VDYGGAEF-IRVP--SG---QIWKPDIVLYN-- -NAV-GDF-QVDDKTKALLKYTGDVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVL--- -------------------------IGSTMNLKDYWESGEWAIIKAPGYKHDIK-Y-NCCEEI-------YT D----ITYSLYIRRLPLFYTINMIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPKT-HT-MPVWVRTIFLNLLPRIMF---MTR--P- ------------------------------------------------------------------------ ---TSDEENNQKPKPFYTSEF-----------------------------------------SNLNCFNSSE -----------------------IKCCKDGFVCQDMACSCCQYQRMKFS----------------------- ---------------------------------------------------------DFSGNLTRSSSSESV D-------------PLFSFSV---------------------------------LSPEMRDAIE-SVKYIAE NMKMQNEAK-EIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFL--QPLMTGDDM----------------- ------------------------------------- >ChineseSoftshellTurtle_scaffoldJH208173_1/1-475 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------CS---------EAEH-RLFASLF-----ANYSQFIRP-VENVSD-PAIIQFE VSMSQLVKVDEVNQIMETNLWLKHIWNDYKLKWNP----EEYGGAEF-IRVP--SD---SIWKPDIVLYN-- -NAV-GDF-QVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVL--- -------------------------IGSTMNLKDYWESGEWAIIKAPGYKHDIK-Y-NCCEEL-------YP D----ITYSLYIRRLPLFYTINMIIPCLLISFLTVLVFYLPS-DC-GEKVTLCISVLLSLTVFLLVITETIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPKT-HT-MPEWVKTIFLNLLPKIMF---MTR--P- ------------------------------------------------------------------------ -------ASDEETTQKLKPLY-----------------------------------------SVELSDLNCF --------------------SSSETKCCKEGFICQDTACSCCRYQRIKFS---------------------- ---------------------------------------------------------DFSGNLTRSSSYESV D-------------ALLSLSV---------------------------------LSPEIRDAIE-SVKYIAE NMKMQNEAK-EIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFL--QPLMTRDEI----------------- ------------------------------------- >Amphioxus_scaffoldNW003101503/1-463 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------MFLPGGVAT---------QSEE-RLFRDLF-----RDYNKWIRP-VANISN-IVVIEFG LAIAQLLDVDEKNQIMTTNVWLKQKWKDSKLCWDP----DEYHGVSV-IRVP--SD---MIWLPDIVLYN-- -NAD-GNY-AVKHNTKAQISSDGMVTWEPPAVYKSSCEIEVTYFPFDQQNCSMKFGSWTYDGFQIDLMM--- -------------------------MDDHVDQGGFSESGEWVIIDAPGQKNIIK-Y-ECCEEV-------YP D----ITFFFVIRRLPLFYTINLIVPCALISFLTVLVFYLPS-DC-GEKITLCISVLLSLTVFLLLITEIIP ATSIVIPVIGEYLLFTMIFVTLSIVITVFVLNIHYRSPST-HR-MPVWVRKIFIDILPRLLS---------- ------------------------------------------------------------------------ -----DVYDYESKTLPRMTTP-----------------------------------------KMRSRHGAKV ---------------------SVTNVSGNPGVGGAEKYNTCD------------------------------ ---------------------------------------------------------SRPSQSQARAQFQSY Q-----------------------------------------------------YSPDILRAAQ-GVNYIAE TLRAKDEAD-SVNEDWKYVAMVIDRIFLWIFVSMCILGTIGLFL--QPLPGFIS------------------ ------------------------------------- >Amphioxus_scaffoldNW003101420_2/1-338 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------AEE-KLFRDLF-----RNYNKWIRP-VMNVSD-NVTVTFG VSISQLIDVDEKNQIMTTNVWLRQEWNDHKLQWNP----EDYDGVTV-LRVP--ST---DLWLPDIVLYN-- -NAD-GQF-QVKQQTKAEVQFDGMVLWVPPAIYKSACAIDVRYFPFDKQNCSMKFGSWTYDGAQIDMKF--- ---------------GAMTYDGANQSLEHQMEREEWSNGEWVLEDAPGARNVVK-Y-ECCPEK-------YI D----ITYHLIIRRLPLFYTINLIIPCLLISFLTVLVFYLPS-DC-GEKMTLCISVLLSLTVFLLVINDIIP STSLVVPLIGEYLLFTMIFVTLSITLTVFVLNIHHRSPNT-HN-MPVWVRKIFIQTLPKLLW---MERHEV- ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------- >Fugu_3/1-626 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------MAPGFSQVAPRA---------HAEE-RLLQDLF-----AHYNKLSRP-VENTTD-TVLVHFG LSIAQLIDVDEKNQMMTTNVWVKQEWNDYKLRWNP----EEYENVTS-IRIP--SE---IIWRPDIVLYN-- -NAD-GDF-AVTHLTKAQLFYDGRIKWMPPAIYKSSCSIDVTFFPFDQQSCKMKFGSWTYDRAKIDLIS--- -------------------------MASDVDQMDYWESGEWVIVNAVGKYNTKK-Y-ECCTEI-------YS D----ITYYFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-QC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMVFVTLSIIITVFVLNVHHRSPQT-HG-MPHWVRRVFLDFVPKVLF---MKR--P- -----------------------------PGTAKQHCKKLIEMMHRPATVSGPGNSQPFWTGLETELRQMGP VHRTIPKALTDSPS--------------------------------------------IHVSSPSPPSSPLA NCNKDNQSLNANTFCQSISGRYSLLSEKQLLHGHKSAASSSSQLSLPPTLPLGLLHKRTNKESNTMASIGRS LSVEHMFDGQKEAPCRGRYRRRSRSFQYCCLHDEG----------------------AGLTRATWGQKKHPS ADHLVEIIMAESTKDTSSLQDFEVST----------------------------ISPAMQRAIE-GVQYIAD HLRAEDADF-SVKEDWKYVAMVIDRIFLWMFVLVCILGSVGLFL--PPWLAGMI------------------ ------------------------------------- >Medaka_7/1-630 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------MDLI KYFSLFFIALSRHVSSQIEPRA---------HAEE-RLLQNLF-----ARYNKLSRP-VQNTSD-TVLVHFG LSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWNP----EDYENVTS-IRIP--SE---IIWRPDIVLYN-- -NAD-GDF-AVTHLTKAHLFYDGQIKWMPPAIYKSSCSIDVTFFPFDQQSCKMKFGSWTYDRAKIDLIS--- -------------------------MASDVDQMDYWESGEWVIVNAVGKYNTKK-Y-ECCAEI-------YA D----ITYYFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-QC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMVFVTLSIIITIFVLNVHHRSPQT-HG-MPHWVRRVFLDLVPRVLF---MKR--P- -----------------------------PGTAKQHCKRLIEMMHCPTTISATGNSQSFWTGLDSELRQMTQ VHNSLPKVDSPRILVCSPSPSSSPVD--------------------------------DCSDEDHPLKADIF CQTPSGQYSPLLEHQALCRHISTTHSAPQLSMPLGPFPCLSREHPSPLARNGRSLSV--------------- ---------------------------------------------------------EQMCGKQGQPPQRSA HRCRSQSFQYCCLHNDGAAGFTGQTNKTPEQLTETLAAEFAKDASTQLDNMAPIVSPAMQRAIE-GVQYIAD HLRAGDADF-SVKEDWKYVAMVIDRIFLWMFVLVCILGSVGLFL--PPWLAGMI------------------ ------------------------------------- >Stickleback_XII/1-588 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------VRPRA---------HAEE-RLLQDLF-----ARYNKLSRP-VENTSD-TVLVHFG LSIAQLIDVDEKNQMMTTNVWVKQEWSDYKLRWKP----EDYENVSS-IRIP--SE---IIWRPDIVLYN-- -NAD-GDF-AVTHLTKAHLFHDGRIKWMPPAIYKSSCSIDVTFFPFDQQSCKMKFGSWTYDRAKIDLIS--- -------------------------MASDVDQMDYWESGEWVIINAVGKYNTKK-Y-ECCAEI-------YS D----ITYYFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-QC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMVFVTLSIVITVFVLNVHHRSPQT-HS-MPHWVRRVFLDMVPRVLF---MKR--P- -----------------------------PGTAKQHCKKLIEMMHRPTAISATGNSLAYWTGLETGLRQMCQ AENALPKTPCDSPSIHVCSPAPPSSPPEDC----------------------------EEDDRLLKANLSLP PALPLGPLRSFSQEEPNAMAPNGRSLSAEQMFDQQGDLSQRAGHRCRSRSFQYCCLHGEGPGLMAVAGWVKK QAPT-----------------------------------------------------NHPAGRVTGESTKDA S-------------TQQDIVIPT-------------------------------ISPAVQRAIE-GVQYVAD HLRAEDADF-SVKEDWKYVAMVIDRIFLWMFVLVCILGSVGLFL--PPWLAGMI------------------ ------------------------------------- >Zebrafish_11_chrna4b/1-627 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MRAAWR VFFLLCVHLQLAYVFSMSPAHA---------HAEE-RLLQSLF-----INYNKLSRP-VANISD-VVLVHFG LSIAQLIDVDEKNQMMTTNVWVKQEWNDYKLRWNP----EEYENVTS-IRIP--SE---IIWRPDIVLYN-- -NAD-GDF-AVTHLTKAQVFYNGRIKWKPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDRAKIDLIS--- -------------------------MASDVDQMDYWESGEWVIINAVGTYNIKK-Y-ECCTEI-------YP D----ITYSFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-EC-AEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIIITVFVLNVHHRSSRT-HS-MPHWVRQLFLHLVPRYLF---MKR--P- -----------------------------------------------------------------------P ASGKRNCGKLIEMMHKQANSQSMFLRNNIL---------------------DISPQSPIPHLGPTSAAQQDQ VQQDSTSPKPLFFCSSPSSQYSILQEENSQTPQTPVLSYTCAYTNSIFASSTTSFPDTLLGTLLHTIPQDGA KSTECDFQGHSAESVFMEAKESVLGAGSCQHCLTSEGTSLQKLDLDEAGRCTRHNMPSAQIFSPSSDGSTDL N-------------AAEPVSN---------------------------------LSQSLLKALE-GVQYIAD HLRAEDSDF-SVREDWKYVAMVIDRIFLWMFVLVCILGTVGLFL--PPWLAGMI------------------ ------------------------------------- >SpottedGar_LG18/1-630 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------MQFLAPCI HALGVLLLLLPLSAYGHTTVRA---------HAEE-RLLKNLF-----TGYNKLSRP-VANISD-VVLVRFG LSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWNP----QDYENVTS-IRIP--SE---LIWRPDIVLYN-- -NAD-GDF-AVTHLTKAHLFHDGQIKWMPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVS--- -------------------------MANNVDQMDYWESGEWVIVDAVGTYNTKK-Y-ECCTEI-------YP D----ITFYFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-EC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIIITVFVLNVHHRSPRT-HT-MPHWVRRVFLDIVPRVLF---MKR--P- -------------------------------TTVKENCKKLIEMMHKKGSTPTFWSEQTFEAEQTFPSSPLD SPDSPPPTSTPPLCHPLEDPPAKVQLLCKS-----------------PSSQYSILLEETSQPGCSSPPASHL LAPDKPCSFPKTRSLSVQYSFGERELPQTTARCRSRSIQYCCLHEESSQSNGHASGKCSRSPTLQSHLL--- ---------------------------------------------------------ADEGTDSGQAPWKCT KIPETAMSSQRAAKLFSAKEQHILL-----------------------------MSPSMKLAIE-GVQYIAG HLRAEDADF-SVKEDWKYVAMVIDRIFLWMFIMVCILGTVGLFL--PPWLAGMI------------------ ------------------------------------- >Coelacanth_scaffoldJH126727/1-553 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------DEKNQVMTTNVWVKQEWYDYKLRWDP----QDYENVTS-IRIP--SE---LIWKPDIVLYN-- -NAD-GDF-AVTHLTKAHLFYDGRINWMPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDRAKIDLVS--- -------------------------MSSQVDQLDYWESGEWFIVSATGKYNIKK-Y-ECCVES-------YP D----ITYFFIIKRLPLFYTINLIIPCLLISCLTVLVFYLPS-DC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRT-HN-MPAWVRRVFLDVIPRLLF---MKR--P- ------------------------------------------------------------------------ STMKENCKKLIELMHKKNNSP-------------------RYLSDIETEPSFAATPSDSQQSKDPSPTSPFC HHIDDSSRPQSICKSPSDQYSVLHEEPTEASCPSPSSQHHHFAEDQSSSPSKGRSLSVEYTFNTSDLPQPNT RCRSRSFQYCHIHEESAQL--------------------------------------NGHGKSPASQHGHVL E-------------DQSQSKPPQCKCNRKKISAAAISSSRSLKSLSTKDQHLLLMSPAMKLAVE-GVQYIAD HLKAEDADI-SVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL--PPWLAGMI------------------ ------------------------------------- >Mouse_20/1-629 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------------MEIGGSGA PPPLLLLPLLLLLGTGLLPASS---HIETRAHAEE-RLLKRLF-----SGYNKWSRP-VANISD-VVLVRFG LSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDP----GDYENVTS-IRIP--SE---LIWRPDIVLYN-- -NAD-GDF-AVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVS--- -------------------------MHSRVDQLDFWESGEWVIVDAVGTYNTRK-Y-ECCAEI-------YP D----ITYAFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-EC-GEKVTLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRT-HT-MPAWVRRVFLDIVPRLLF---MKR--PS VVKDNCRRLIESMHKMANAPRFWPEPESEPGILGDICNQGLSPAPTFCNRMDTAVETQPTCRSPSHKVPDLK TSEVEKASPCPSPGSCHPPNS---------------SGAPVLIKARSLSVQHVPSSQEAAEGSIRCRSRSIQ YCVSQDGAASLTESKPTGSPASLKTRPSQLPVSDQTSPCKCTCKEPSPVSPI-------------------- ---------------------------------------------------------TVLKAGGTKAPPQHL P-----------------------------------------------------LSPALTRAVE-GVQYIAD HLKAEDTDF-SVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL--PPWLAGMI------------------ ------------------------------------- >Human_20_CHRNA4/1-627 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MELGGP GAPRLLPPLLLLLGTGLLRASS---HVETRAHAEE-RLLKKLF-----SGYNKWSRP-VANISD-VVLVRFG LSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDP----ADYENVTS-IRIP--SE---LIWRPDIVLYN-- -NAD-GDF-AVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVN--- -------------------------MHSRVDQLDFWESGEWVIVDAVGTYNTRK-Y-ECCAEI-------YP D----ITYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-EC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRT-HT-MPTWVRRVFLDIVPRLLL---MKR--PS VVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGPSCKSPSDQLPPQQP LEAEKASPHPSPGPCRPPHGT----------------QAPGLAKARSLSVQHMSSPGEAVEGGVRCRSRSIQ YCVPRDDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSVSPS------------------- ---------------------------------------------------------ATVKTRSTKAPPPHL P-----------------------------------------------------LSPALTRAVE-GVQYIAD HLKAEDTDF-SVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL--PPWLAGMI------------------ ------------------------------------- >HighHimalayaFrog_scaffoldNW017306285/1-679 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------MGHPRAPPCTVPGLRSAGDGTWRRATLRRRSLSLPTCANTSSQGVNLPYLTGIMGSGAFKET LQLLLLMWIFFPSVLCHTEIRA---------HPEE-RLLKKLF-----LEYNKWSRP-VANISD-AVLVRFG LSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDP----LEYDNVTS-IRIP--SE---LIWRPDIVLYN-- -NAD-GDF-AVTHLTKAHLFYDGRIKWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDRAKIDLIS--- -------------------------MHSHVDQLDYWESGEWVIVNAVGNYNIKK-Y-ECCTEI-------YS D----ITYSFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-EC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIIITVFVLNVHHRSPRT-HT-MPAWVRRIFLDVVPRVLF---MKR--P- ----------------------------------------------------------------------AK DNCKKLIESLLHSRPLSSPPR-----------------------------LWSETEIEPALPSSSSASPTSQ RVSPTSSCCQQLEQTANSQVVCKSPSGQYSMLCEESTLTSCPCPPNQTGLLGEPQTNLMPKVRSVSVQQMYT PKETSEATIRCRSRSIQYCYLHEDS--------------------------------SQANGQSSASPQSQS CHVHEAQQTSNSQCKCKPKTQEKPSGASQVTKTVSTKEQHVLL-----------MSPSLKLAIE-GVHYIAD HMRAEDADF-SVKQDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL--PPWLAGMI------------------ ------------------------------------- >Opossum_1_6/1-631 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------------MRLQGPQGSALLLL LLRGLLILGVLLPASGHVETRA---------HAEE-RLLKKLF-----SGYNKWSRP-VANISD-VVLVRFG LSIAQLIDVDEKNQMMTTNMWVKQEWQDYKLRWDP----MDYENVTS-IRIP--SE---LIWRPDIVLYN-- -NAD-GDF-AVTHLTKAHLFYDGRIKWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVS--- -------------------------MHSHVDQLDYWESGEWVIISAVGNYNIKK-Y-ECCTET-------YS D----ITYSFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-DC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIIITVFVLNVHHRSPRT-HT-MPAWVRRVFLDIIPRLLF---MKR--P- -----------------------------------GVVKDNCRKLVESMHKLAGGPRFWPQPEPNFVTSPST SPQTPERSPSASFCVHLEDPV---------------------------KPQAVCKSPSGQYTVLQRPEPGKG SPCSPPTPHPPLNNSHPSGFSKVRSLSVQQMYSSNKVEEGSIRCRSRSIQYCSLQEDSSQANNGQSTSSPAS LRSQK----------------------------------------------------DEVQPQEKPSPCKCK CKKVKATPVPDPVTKPRSTKEQHALP----------------------------MSPALKLAVE-GVQYIAD HLKAEDTDF-SVKEDWKYVAMVIDRIFLWMFVIVCLLGTVGLFL--PPWLAGMI------------------ ------------------------------------- >Chicken_20/1-622 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------MGFLVSK GNLLLLLCASIFPAFGHVETRA---------HAEE-RLLKKLF-----SGYNKWSRP-VANISD-VVLVRFG LSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDP----QEYENVTS-IRIP--SE---LIWRPDIVLYN-- -NAD-GDF-AVTHLTKAHLFYDGRIKWMPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLVS--- -------------------------MHSHVDQLDYWESGEWVIINAVGNYNSKK-Y-ECCTEI-------YP D----ITYSFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-EC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIIITVFVLNVHHRSPRT-HT-MPDWVRRVFLDIVPRLLF---MKR--P- -----------------------------------------------------------------------S TVKDNCKKLIESMHKLTNSPR-------------------------------LWSETDMEPNFTTSSSPSPQ SNEPSPTSSFCAHLEEPAKPMCKSPSGQYSMLHPEPPQVTCSSPKPSCHPLSDTQTTSISKGRSLSVQQMYS PNKTEEGSIRCRSRSIQYCYLQEDSSQTNGHSSASPASQRCHLNEEQPQHKPHQCKCKCRKGEAAGTPTQGS K-------------SHSNKGEHLVL-----------------------------MSPALKLAVE-GVHYIAD HLRAEDADF-SVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL--PPWLAGMI------------------ ------------------------------------- >AnoleLizard_4/1-625 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------MGPLAFQ EQLILLLCANFFPAFSHVETRA---------HAEE-RLLKKLF-----SGYNKWSRP-VANISD-VVIVRFG LSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDP----EEYENVTS-IRIP--SE---LIWRPDIVLYN-- -NAD-GDF-AVTHLTKAHLFYDGRIKWMPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLES--- -------------------------MHRHVDQLDYWESGEWVIINAVGNYNIKK-Y-ECCSEI-------YP D----ITYSFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-EC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIIITVFVLNVHHRSPRT-HT-MPDWVRKVFLDVVPRLLF---MKR--P- -------------------------------------TTVKDNCKKLIESMHKIANSQRFWSETEVEPKFTT SSSNSPQSNEQSPTSSFCTHL------------------------DDQAKLPPPLCKSPSGQYSMLLAEPIR ASCTSLQPPCHSRDSQSSSMSKSRSLSVQQMYSSPGKAEEGTIRCRSRSIQYCYLQEES------------- ---------------------------------------------------------SQTNGQSSGSPASPR CHLNEEQPKTKPIHCKCKCKKNESASTSGHGSKTLGSKDQQVLL----------MSPALKLAVE-GVHYIAD HLRAEDADF-SVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL--PPWLAGMI------------------ ------------------------------------- >Stickleback_scaffold74/1-518 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------DWTRV---------HSED-ELFRSLF-----RPYSKWTRP-ARNITD-VVIVKFG LSIAQLIDVDEKNQMMTTNVWLKQEWTDYKLQWSP----SDFDNVTS-IRVP--SE---LLWVPDIVLYN-- -NAD-GEF-AVTHMTKAHVFHTGRVRWVPPAIYKSSCSIDVTFFPFDQQSCKMKFGSWTYDRAKIDLEP--- -------------------------FEDTVDLKDYWESGEWAIVNAVGTYNTKK-Y-DCCHEI-------YP D----ITYYFVIRRLPLFYTINLIIPCLLISFLTVLVFYLPS-DC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIVITVFALNVHHRSSET-HA-MPRWVRGLFLSAVPRWLC---MKR--P- ---------------------------------------------------------------------EHG VRPARRLHLTDRLLPLRTSGP-----------------AHSSAAWVTQESDVDLRGYQKEGDGCRGSGDEKH YCRLHGYSDAAHLGRFGPRIPPLSPPLGHMLLPRRNPPLGSDWD---------------------------- ---------------------------------------------------------ALRVERGSAWSPAAC A-----------------------------------------------------LSPAVVSALE-GVTYIAE HLRAEDADL-SVKEDWKYVAMVVDRIFLWMFVIVCLLGTVGLFL--PPWLSGMF------------------ ------------------------------------- >AnoleLizard_scaffoldNW003339243/1-527 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MDPFRT FRIVAWYCFVLLPASVQSRTQT---------QAEE-RLFRYLF-----NTYNKWSRP-VPNTSD-VVIVRFG LSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLQWNP----LDFDNVTS-IRVP--SE---MIWIPDIVLYN-- -NAD-GEF-AVTHMTKAHLFSNGSIKWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLES--- -------------------------MEHQVDLKDYWESGEWAIINAVGTYNTKK-Y-DCCTEI-------YP D----ITYSFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-DC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPST-HK-MPRWVRNFFLDFVPRWLF---MRR--P- ------------------------------------------------------------------------ ----PLVPPGLKAAGEETVGQ-----------------------------------------YDVPPANLST SQCWLEADLHDKWDGEEEEGGEERRRRGQLPLQGLCHNHCLQYRYTCARHLGRSFVELIQR----------- ---------------------------------------------------------PAAKTENLATSEPGL Q-----------------------------------------------------LSPGILKALE-GVHYIAN HLRAEDADF-SVKEDWKYVAMVIDRIFLWMFVIVCLLGTIGLFL--PPFLAGMI------------------ ------------------------------------- >Opossum_1_7/1-474 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ---------------KHASHAL----------DED-RLFKKLF-----RGYNRWSRP-VQNSSD-VVIIRFG LSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNP----TDYGNITS-IRVP--SE---LIWIPDIVLYN-- -NAD-GEF-IVTHMTKAHLFFTGTVKWAPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQ--- -------------------------MEQMVDLKDYWESGEWAIINAVGTYNTKK-Y-DCCVEI-------YP D----ITYFFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-DC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPGT-HN-MPHWVRVAFLGCIPRWLW---MNRPLP- ----------------------------------------------------------------------VL EFHDNPGQKLSSTHHWLDTNV--------------------------------------------------- ------------DEDKKSEENWEFSGHSSPVIDTLYHHCGHHHE---------------------------- ---------------------------------------------------------SPCFKAGTQLPETEF L-----------------------------------------------------LPPSIQKALE-GVHYIAD HLRTEDADF-SVKEDWKYVAMVIDRIFLWMFIIICFLGTIGLFL--PPLLAGMI------------------ ------------------------------------- >Mouse_14/1-512 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------MAPSHPAFQFWI HLYLWCLLLMPAVLAQQGSHTH----------AED-RLFKHLF-----GGYNRWARP-VPNTSD-VVIVRFG LSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDP----AEFGNITS-LRVP--SE---MIWIPDIVLYN-- -NAD-GEF-AVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQ--- -------------------------MERTVDLKDYWESGEWAIINATGTYNSKK-Y-DCCAEI-------YP D----VTYYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-EC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPST-HN-MPNWVRVALLGRVPRWLM---MNR--P- ------------------------------------------------------------------------ ---LPPMELHGSPGLKLSPTY--------------------------------------------------- -HWLETNMDAEEREETEEEEEEEEDENICMCAGLPDSSMGVLYGHGSLHLR--------------------- ---------------------------------------------------------AMGPEAKTPSQASEI L-----------------------------------------------------LSPQIQKALE-GVHYIAD HLRSEDADS-SVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFL--PPFLAGMI------------------ ------------------------------------- >Human_8_1_CHRNA2/1-529 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------MGPSCPVFLSFTKLSLWWLLLTPAGGEEAKRPPP RAPGDPLSSPSPTALPQGGSHT---------ETED-RLFKHLF-----RGYNRWARP-VPNTSD-VVIVRFG LSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNP----TDFGNITS-LRVP--SE---MIWIPDIVLYN-- -NAD-GEF-AVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQ--- -------------------------MEQTVDLKDYWESGEWAIVNATGTYNSKK-Y-DCCAEI-------YP D----VTYAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-DC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPST-HT-MPHWVRGALLGCVPRWLL---MNR--P- ------------------------------------------------------------------------ ----PPPVELCHPLRLKLSPS--------------------------------------------------- --YHWLESNVDAEEREVVVEEEDRWACAGHVAPSVGTLCSHGHLHSG------------------------- ---------------------------------------------------------ASGPKAEALLQEGEL L-----------------------------------------------------LSPHMQKALE-GVHYIAD HLRSEDADS-SVKEDWKYVAMVIDRIFLWLFIIVCFLGTIGLFL--PPFLAGMI------------------ ------------------------------------- >Chicken_3/1-528 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -----------------------------------------------------------------------M GWPCRSIIPLLVWCFVTLQAAT-REQKQPHGFAED-RLFKHLF-----TGYNRWSRP-VPNTSD-VVIVKFG LSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNP----EDFDNVTS-IRVP--SE---MIWIPDIVLYN-- -NAD-GEF-AVTHMTKAHLFSNGKVKWVPPAIYKSSCSIDVTYFPFDQQNCKMKFGSWTYDKAKIDLEN--- -------------------------MEHHVDLKDYWESGEWAIINAIGRYNSKK-Y-DCCTEI-------YP D----ITFYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-DC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIIITVFVLNVHHRSPST-HT-MPHWVRSFFLGFIPRWLF---MKR--P- ------------------------------------------------------------------------ -----PLLLPTEGTTGQYDPP-----------------------------------------GTRLSTSRCW LETDVDDKWEEEEEEEEEEEEEEEEEKAYPSRVPSGGSQGTQCHYSC------------------------- ---------------------------------------------------------GRQAGKASGGPAPQV P-------------LKGEEVGSDQGLT---------------------------LSPSILRALE-GVQYIAD HLRAEDADF-SVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL--PPYLAGMI------------------ ------------------------------------- >Zebrafish_17_chrna2a/1-520 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------MAENRI KTLLNNLWMLILIADHVQPVLS---DGWIHAHAED-KLFHKLF-----IGYNKWSRP-VRNISD-VVIVKFG LSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWNP----SEFDNVTS-IRVP--SE---MIWVPDIVLYN-- -NAD-GEF-AVTHMTKAHLFHTGKVSWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQ--- -------------------------IEGTVDLKDYWESGEWAIINAVGTYNTKK-Y-DCCHEI-------YP D----ITYFFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-DC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPST-HS-MPRWVHSVFLDHIPRWLF---MRR--P- ------------------------------------------------------------------------ ---EPEKKPKKTANLSTSKSW-----------------------------------------FQQETGVDGL VCQDMEFGIGLSTSISSPSATSLHLSDSEPLLQKYELQHLGHVVNLC------------------------- ---------------------------------------------------------QHPAKLGNLVSEPGL L-----------------------------------------------------FSPCVLRALE-GVRYIAD HLRAEDEDF-SVKEDWKYVAMVIDRIFLWMFIIVCLLGTIGLFL--PPWLSGMI------------------ ------------------------------------- >SpottedGar_LG1/1-532 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------MESNFKKMFSV RTTLFCCFILCKSLFCHENTHS---------HAEE-DLFKKLF-----IGYNRWSRP-VPNISD-VVIVKFG LSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWKP----SDYDNVTS-IRVP--SE---MIWVPDIVLYN-- -NAD-GEF-AVTHMTKAHLFYNGMVQWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLER--- -------------------------IENTVDLKDYWESGEWAIINAVGTYNTKK-Y-DCCHEI-------YP D----ITYFFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-DC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPST-HK-MPRWVRTVFLEFIPRWLF---MKR--P- ------------------------------------------------------------------------ -----TLDEKRQRLLQQQNHS-----------------------------------------EAKLSTSRYW LETDVDLKCDDAELGLPSFSFSSASAASPRLIPAHSPLPQKHNLHHRLEGMARQLGGRVNPT---------- ---------------------------------------------------------QRPAKIDNLVSDSNF P-----------------------------------------------------FSPSILRALE-GVHYIAD HLRAEDADF-SVKEDWKYVAMVIDRIFLWMFIIVCLLGTIGLFL--PPWLSGMI------------------ ------------------------------------- >Zebrafish_20_chrna2b/1-550 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ -------------------------------------------------------------------MASFT NQLVFLRITLLCTIICESISCC----EKTHSHAED-ELFKKLF-----DGYNKWSRP-VPNTSD-VVIVKFG LSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWKP----SDYDNVTS-IRVP--SE---LIWVPDIVLYN-- -NAD-GEF-AVTHMTKAHLFHTGKVRWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLER--- -------------------------IENTVDLKDYWESGEWAIINAVGTYNTKK-Y-DCCHEI-------YP D----ITYFFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-DC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPST-HK-MPCWVHSVFLDLIPRWLF---MRRPAP- -----------------------------------------------------------------------D SRRRQKLLLLQRQVPGMTARP----------------------------ANASLSTSTSWFRGQNSGEDESC RHFSYKDLELGTLSSAISLSLQASSPCPLGLTPPPLQKFGPAPRLEVGTASRQ------------------- ---------------------------------------------------------LSGRANVTKRLDNMI P-------------HDNPGFP---------------------------------LSPSVLQALE-GVHYIAD HLRAEDADF-SVKEDWKYVAMVIDRIFLWMFIIVCLLGTIGLFL--PPWLAGMI------------------ ------------------------------------- >Medaka_24/1-555 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ----------------------------------------------------MKLGKPVDREMEMNPLFFTG AHVVWALLLTPAVFCYDKSHAH----------AEE-ELFQTLF-----TGYNKWSRP-VPNISD-VVIVKFG LSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWKP----SDYDNVTS-IRVP--SE---LIWVPDIVLYN-- -NAD-GEF-AVTHMTKAHLFHTGKVRWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLER--- -------------------------IENTVDLNNYWESGEWAIINAVGTYNTKK-Y-DCCHEI-------YP D----ITYFFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-DC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPST-HK-MPRWVHTVFLDLIPRWLF---MRR--P- ------------------------------------------------------------------------ ---APNGRRRRLLLLQQDGAL-----------------------------------------GRLQPRVSAL DISTSSTWLREGAVLEKTERSCYEDLELGTLQSYFSFRPPSPRPPGQTPPQQLKT----------------- ---------------------------------------------------------PQNSQSWREGGGGPN RQMGGARVDSPKVQCAESGSL---------------------------------LSPCVMRALE-GVHYIAD HLRAEDADF-SVKEDWKYVAMVIDRIFLWMFIIVCLLGTIGLFL--PPWLAGMI------------------ ------------------------------------- >Fugu_16/1-550 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------MRRN HLFGSMLAVLCWLFSSQTVLCS----QKTHSHAED-DLFKKLF-----AGYNKYSRP-VPNVTD-VVIVKFG LSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWRP----SDYDNVTS-IRVP--SE---LIWVPDIVLYN-- -NAD-GEF-AVTHMTKAHLFYNGKILWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLER--- -------------------------IENTVDLNNYWESGEWAIINAVGTYNTKK-Y-DCCHEI-------YP D----ITYFFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-DC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPST-HK-MPRWVHSVFLDLIPRWLF---MRRPAP- -----------------------------------------------------------------------D GRRRRLLLLQQEVMAERRRGR-----------------------------------------LTGYKSGNYL --STSANWLMDGSLSDEPNRNSYEDLELGMLTSYFSFRPPSPRPLGTPPPTQ-------------------- ---------------------------------------------------------QNSQKKQDGPVGTNK QLSGARITAQRLTKADSTVSDSSFL-----------------------------LSPSIIRALE-GVHYIAD HLRAEDADF-SVKEDWKYVAMVIDRIFLWMFIIVCLLGTIGLFL--PPWLAGMI------------------ ------------------------------------- >Stickleback_XVIII/1-533 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------LCHEKSHS---------HAED-DLFKTLF-----AGYNKWSRP-VSNISD-VVIVKFG LSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWKP----SDYDNVTS-IRVP--SE---LIWVPDIVLYN-- -NAD-GEF-AVTHMTKAHLFHNGKVRWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLER--- -------------------------TENTVDLNNYWESGEWAIINAVGTYNTKK-Y-DCCHEI-------YP D----ITYFFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-DC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPST-HK-MPHWVHSVFLNLIPRWLF---MRRPAP- ---------------------------------------------------------------------DVR RRRLALMQQDAALVRRQGRAG-----------------------------------------GYKRPSNCLS TSATWSGGGSASEDPDRSSYEDLELGTLTSYFSFRPPSPRPPGATPPPQPKNPQNSQNQQ------------ ---------------------------------------------------------EGPAGTNRLSTGSRV NLTQRAVKADNAVSDSTFL-----------------------------------LSPSVIRALE-GVHYIAD HLRAEDADF-SVKEDWKYVAMVIDRIFLWMFIIVCLLGTIGLFL--PPWLAGMI------------------ ------------------------------------- >Coelacanth_scaffoldJH128810/1-492 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------ACHMKTRT---------HAEE-RLFNSLF-----TAYNRLSRP-VSNISD-VVIVKFG LSIAQLIDVDEKNQMMTTNVWLNQEWNDYKLRWNP----ADYDNVTS-IRVP--SE---IIWIPDIVLYN-- -NAD-GEF-AVTHMTKAHLFHTGKIQWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDRAKIDLQS--- -------------------------IDKNVDLRDYWESGEWAIVHAVGTYNTKK-Y-DCCFEI-------YS D----ITYSFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-GC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSMST-HK-MPQWVRVVFLDFVPRWLC---MKR--P- ------------------------------------------------------------------------ ---EPSKVLDDTFVNHYSFSD-----------------------------------------FKLSTSDSWW DTDIDGNLEEADSGLHSCHTRETGSHNHSIQYDHYRQENGRVNEP--------------------------- ---------------------------------------------------------LNPTNMDNLESDSNI L-----------------------------------------------------LSPSILQALE-GVQYIAD HLRAADADF-SVKEDWKYVAMVIDRIFLWMFIIVCLLGTMGLFL--PPWLAGMI------------------ ------------------------------------- >WesternClawedFrog_5_2/1-510 ------------------------------------------------------------------------ ------------------------------------------------------------------------ ------------------------------------------------------------------------ --------------------------------------------------------------------MENC MGRTLSILCWIITFTTVSCMER------TRTHAEE-RLFKRLF-----TGYNRWSRP-VPNTSD-VVIVKFG LSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWNP----ADYDNVTS-IRVP--SE---MIWIPDIVLYN-- -NAD-GEF-AITHMTKAHLFHNGKVKWVPPAIYKSSCSIDVTFFPFDQQSCKMKFGSWTYDKAWLDLES--- -------------------------MERNVDLKDYWESGEWAIVNAVGKYNSKK-Y-DCCTEI-------YP D----ITYYFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPS-DC-GEKITLCISVLLSLTVFLLLITEIIP STSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPST-HK-MPLWVRSVFLDHIPRWLF---MKR--P- ------------------------------------------------------------------------ -------PAPVEEVVSQYDAP-----------------------------------------ELKLSTSKYW METDVDDKWAEPEAELQTCHVRHMTTHNQSLQYRYDYNHHVSGGQS-------------------------- ---------------------------------------------------------QTPRHSSTETAESSF L-----------------------------------------------------LSPSVLKALE-GVHYIAN HLRAEDADF-SVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFL--PPFLAGMI------------------ -------------------------------------