>Aplysia_tr_Q8I818_AAN83922.1 -----------------------------------MLRFLVFALPVAAVL LALA-------VTAQPPDNASGN---ICC-QRDLI------------NYT VLSEN----------GTSAGGKGVR-RSINAKFNLDFPKTRLS--SKGSM VIFDESGIKNI-EFWVITKSD--KSIAIDE-------------------- -------------------------------------------------- ---------------------------------------------AQKSC GQ--IPLV------WFPRFCVPSTAQKVGSYSYGP---AGQTFQTDAYKF R--LGDSD----------FFATIA---PDCTIINLVQAVT---------- -----------------------------------SPNGG-----SLV-S SVLTDIQPTVDE--SAFELPP-YCKESFD-----------STVA------ -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Lingula_XP_013415911.1 ------------------------------------MDVRISFVFILNTL LGAQ----------GLQSSVKDA---TCC-VPTQF------------EAK VYMDAELVFLDTTSSVSRPLTAYSM-FNYTVHLAYDYDRQQLYMHANVTE TSPLIPHPVTD-SVLYLFDHKHGVMYTVNG-------------------- -------------------------------------------------- --------------------------------------------GHDGKC QKDNSTVP-------MSQQCIPDDALLQRNSAIGNPSLQPLAAKVYQYEV KGDPDAFP------FYIQAFVKQN--GKQCLPMKLH--VV---------- -----------------------------------TAGGS---GTMNAWV MNFVNLTQGIQDP-SIFSVPG-PCRGATQ-----------VTKITTAQEP KWKQALEVLLGTIN------------------------------------ -------------------------------------------------- ------------------------------------- >Capitella_tr_R7UTM4_ELU09867.1 -----------------------------------MVTILWILGALLGCA FGVK---------------FDAL---KCC-APEVW------------EAR IVNTG-----------TTNRQKYSF-NNMDISFAYDLPNDRWA-----ID QVHPVDESKNL-KLVFDYNLG--KKYAI---------------------- -------------------------------------------------- ---------------------------------------------NTAGC FV--EPLD---AH--LNPYCIGKNATFLGEFGAGL---PRHGQYHRAWSY D--IFMFP--------LRHTLVVS--KEHCLPIKEV--TYSLIQNSRHFF NNAWAWNHGEFPCNPWEEPGILELGECFKSHRKIKKEVQGTQPTAFVL-N MDYVDLNTTITNE-GIFQVPE-QCPNDSW-----------DSVKLTDFWR ILIMRMKFYDEVKDAPGLD------------------------------- -------------------------------------------------- ------------------------------------- >Capitella_tr_R7UYA9_ELU11294.1 ----------------------------------MRSVCILVALFAGACC LPVI---------------SSSG---GCV-YPPRW------------ESF LAERM--------RTKMTASGTETT-MAVMGNMYADYNAKKAA-----IH FTIYQEAPYQV-SAIADWEAS--AIFAFYP-------------------- -------------------------------------------------- ---------------------------------------------DTGRC VR--SALS---GS--MVEQGVPPNASHLSSFRWGH---GHNAVTVDQWKS T--VNYEK---PWPSRVELFQMVT--TDECVPVVEQ--GT---------- -----------------------------------NHVPG---AEVAF-D VSFANFNTTITNP-LAFNPPD-YCADAPV-----------VDTPGPLVQG LMMRFMFTSS---------------------------------------- -------------------------------------------------- ------------------------------------- >Capitella_tr_R7TWV9_ELT98092.1 ------------------------------------MRAVCTLLALFAAS AVAF----------------SPQ---PCA-YPPQW------------ESF FGERL--------RIKTTDTGAETT-LVVMGNMYVDYIGKKVG-----LH YTIQQDAPYTL-TIIGNFETQ--AMVAFYP-------------------- -------------------------------------------------- ---------------------------------------------DKQQC IR--VPLQ---QS--MQQQGVTSSARHLSSFRWGH---SPNAVLVNQWQS T--INFDK---PWPCRIDLFQMVT--TDECVPVVEQGTNY---------- -----------------------------------IQGME-----IAF-D SSFANFNTTITNP-LAFTSPE-YCTNAPV-----------VNTPSTLVES LMMRFIRY------------------------------------------ -------------------------------------------------- ------------------------------------- >Lottia_tr_V3ZIT2_XP_009065268.1 ------------------------------------MKCLCVVLIVYCCV LIVA----------------SND---PCC-TSNAF------------ETV LSEAG----------GIYVSNATTVPIDVWNKMYYDFNRKMMT---LETH TRLSTGYYKQI-KIIMDFRQQ--LEFAI---------------------- -------------------------------------------------- ---------------------------------------------EKGNC TV--IPVK---ES--MQKPCIPKNATYLGSNSIGY---ADEAIEFTSWEF E--TPNSD--------VSTKLTVS--SKGCVPLTQS--MY---------- -------------------------------VNRGMCLHTTPNNKTAV-S YTFANFKPMITND-AVFQIPA-NCQQVHS-----------HIAP------ -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Lottia_tr_V4B6H4_XP_009065265.1 -----------------------------------MLVSFLTLLLILSSG NGQT-----------------TK---NCC-LPDEY------------EMD MGETG----------STFKDNVFQE-MQGFLSTSYSHKDRKVS----SRG TNVVNGQLVQT-TVLMDYKTH--REYIN---------------------- -------------------------------------------------- ---------------------------------------------VNGNC TV--YEMK---AP--MINPCIPDNALFGGRTRYGY---GSNHIDVDLWRF N--LSNRP-------DSPIKLSIT---DDCTPITQT--QF---------- ------------------------------------DPKALLGGKTEV-V YIFSNFRPGIKAR-NIFTVPT-ECHNKPV-----------LKHHL----- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Lottia_tr_V3ZIS7_XP_009065263.1 --------------------------------------MIALLVLAFVAV STAQ----------------DPP---RCC-IDKEF------------EAY LDEAG--------SFVSAQDKEFHP-LKGYTTVAYDYYAKKMS--LR-VH NTFENGTEIAG-TLIFDYENK--LEYAI---------------------- -------------------------------------------------- ---------------------------------------------YKRKC TI--YKLP---LP--MRSPCISDNATYDGELTMGY---GAHTLKLHTWKD V--QPGTN--------FPVKLSVS--IDGCVPVVES--IY---------- -----------------------------------VDTPK---AKSEI-V YIISNFHAGIKNR-KRFTIPN-SCHGVTV-------------KESTLIG- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Lottia_tr_V3Z0U7_XP_009065264.1 ------------------------------------MIALLVPVLAFVAV STAQ----------------DPP---RCC-IDKEF------------EAY LDEAG--------SFVSAQDKEFHP-LKGYTTVAYDYYAKKMA--LR-VH NTFENGTEIAG-TLIFDYENK--LEYAI---------------------- -------------------------------------------------- ---------------------------------------------YNRKC TI--HKYP---LQ--MREPCIPDNATYEGKLTMGY---GAHVLQLNTWKY I--QPKTH--------FPVKLSVS--VDGCVPVVES--IY---------- -----------------------------------MTGSK---SKSEI-V YIISNFHAGIKNR-KRFTIPN-SCHGVNV-------------KETTLVG- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Haliotis_P86734 -----------------------------------MILQAALFLAGLTVV SGSI-----------------------CC-PPKQF------------NSY QYVTF--------------VNSTTT-IRALYYIVYDGDNQRYL----ITG DRNNKQLVGTT-KVIYDYKKR--IAYSIDA-------------------- -------------------------------------------------- ---------------------------------------------KARTC SK--FPVQGQFED--QENVCVPGGAEILGPLFYGY---NQSRLNSQSYAY N--TTSLD-------GSHHNVVTTVSEDDCVPIVIC-------------- -----------------------------------TITTGGPGGNSLY-T VGYNDFYPGIKDI-TVFDIPP-YCNA------------------------ -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Haliotis_P86729 --------------------------------------MILQVVLLLACL SGAI---------------VSTG---ACC-PPSRF------------NAF QYVTI--------------VNSTTR-TRGLYYMVYDGPNERYL-----LT GDRLKNLYGTT-RVIYDYKKG--IAYNIDV-------------------- -------------------------------------------------- ---------------------------------------------QKRSC TT--FPLHGKFED--QENVCVPRDAVYTGRSAYGF-----DQGALHSWSY E-----YNRTHPDGRHQNIETTVT--KENCIPIVTT-------------- -----------------------------------TISTDASGGNSLH-I LGYNDFYPGIRDI-SMLEIPS-YCRA------------------------ -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Capitella_ELT94332.1 --------------------------MATERRNSCERRFFNEYCIMLLVD FASS-----------YREGLITV---KSI-ELRNV------------ASE TCKTA---------------NHVGN-IDGLPDPEDKLTITRFS-----DR YITSNTDPCNR-STCKCNKEG--YKYVI---------------------- -------------------------------------------------- ---------------------------------------------RGDAC NG--IRTE---EV--MRKMCLPEGAKLKGHFRLGI------DIPADFWEF Q--APHNV---------TMKTLVL--RETCIPVSEE--VY---------- -----------------------------------MAKGG---YASMT-S TTYMDVSLGIKDR-SVFDRPA-DCEVDMM-----------SHYEDYNHVS QKRFDGHDSVLKALEKRTEN------------------------------ -------------------------------------------------- ------------------------------------- >Capitella_tr_R7TLH0_ELT94332.1 --------------------------MATERRNSCERRFFNEYCIMLLVD FASS--------------YREGLITVKSI-ELRNV------------ASE TCKTA---------------NHVGN-IDGLPDPEDKLTITRFS-----DR YITSNTDPCNR-STCKCNKEG--YKYVI---------------------- -------------------------------------------------- ---------------------------------------------RGDAC NG--IRTE---EV--MRKMCLPEGAKLKGHFRLGI------DIPADFWEF Q--APHNV---------TMKTLVL--RETCIPVSEE--VY---------- -----------------------------------MAKGG---YASMT-S TTYMDVSLGIKDR-SVFDRPA-DCEVDMM-----------SHYEDYNHVS QKRFDGHDSVLKALEKRTEN------------------------------ -------------------------------------------------- ------------------------------------- >Pladu_comp2265193_c0_seq2 -----------------------------------MESHGIILMTLVIAL LGGV---------------LE-G---ARL-RPHSSRARKCKCVPDQWEGV LASTE--------REFDLKGGRQGA-MDNDLYVSYDYRNKRFS------- ---MTDLKTGN-KAIADYHKG--FKYVL---------------------- -------------------------------------------------- ---------------------------------------------REDGC RG--IPTQ---EG--MRQMCLPEQAEYLGEFLLGA-----DE-AVDLWQF S--GPYNI--------T-MKTTVI--QKNCVPVTEE--VY---------- -----------------------------------MSKGT---YVSLQ-T SLYLDVTVGIKDE-SVFHAPL-DCMLDTY--RMPSNAIPQQTKRAQKLEG MWSLLSMLRDDITK------------------------------------ -------------------------------------------------- ------------------------------------- >Pladu_comp2262954_c0_seq14 ------------------------------------MNSSIITVILASCF ALSMARTVISDSKTQGIKQSDQK---RCC-FPQKW------------QGY MRQMI-------------YGEGIPT-MEVFYDYAVDSYKRKTA-----MR MVDPVTYQETS-RNVIDFQKN--VVYNI---------------------- -------------------------------------------------- ---------------------------------------------TDGKC IK--IPRL---SMIEEPMMCLPEKAEYISDFFVGG---TADGWKASYWKA H--NVSES--------TKYLEIAF--TPSCVPVFRK--SI---------- -----------------------------------VSYYG---VELTV-V ENFADVASRIQTP-DIFNVPG-HCKDMTS-----------LVS------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Pladu_comp2243698_c0_seq2 ------------------------------------MFSLLVLSLFLSVA YGSL---ISPRLVHQTIEDPNPK---RCC-LPDHW------------QGY INEII----------------YIKA-ANINQEVIYEYAVKTPE-KFAAFK IVEKFTRKVLS-RGVIDYNTN--VFYNI---------------------- -------------------------------------------------- ---------------------------------------------SDTTC VK--SPRP---AVFEEPLHCMP-NAEHLGDYFVGG---TADGWRASYWIA H--NVTKR-------MKYLEISLS--HDNCLPIAES--II---------- -----------------------------------FDAGA----DLKI-T ANFVNIESRITDP-SIFDVPA-GCKNSVP-----------KEIRGAELRH PRKDYV-------------------------------------------- -------------------------------------------------- ------------------------------------- >Pladu_comp2205583_c0_seq1 -------------------------------------MVYLVILSLCLCL ASAT------------DIQAKPE---KCC-VSDDW------------QGN IAQVM----------------YIPA-AKQYMELDYEYAYKRKE-RLGGFR ILDPATGKEMS-RGVLNFMTN--MLYNI---------------------- -------------------------------------------------- ---------------------------------------------TGSTC VK--SARP---AAYVEPLHCLPDDAEYLGDYFVGG---EMDGWKASYWRV R--NFSET--------IKFIEIAF--SKNCFPVYNK--VI---------- -----------------------------------MDIGV----ELKF-T ANFGNTASRITDP-TIFEIPA-SCNTA----------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Pladu_comp2273538_c0_seq6 -------------------------------------MMYLALLFVSICL ASAT------------DNQPKPE---KCC-FPDNW------------QGN IAQVL------------YIPAAKQY-RETDSEYAYMRSKRMSG-----FR ELDPSTGKPLS-RGVVDYNSN--VFYNI---------------------- -------------------------------------------------- ---------------------------------------------TGSTC IK--SARP---AAFVEPFSCMPDDAEYLGDYYVGG---EVDGWKASYWRA R--DISET--------LKSLEIGF--SKNCIPVYEK--II---------- -----------------------------------LDVGT----ELKI-T ANFGNIASRITDP-TIFEIPE-GCEGV----------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Pladu_comp2268869_c0_seq6 ------------------------------------MSLLLILLGFVSVT LARV--------AVSDQEKLAPK---PCC-FPKTL------------QVN FFGAE-----------FFETASPSL-VPLIGTYAIKSDEGTAA-----LQ VLDGKTRLPVR-KEILDYNSK--ILYNISA-------------------- -------------------------------------------------- ----------------------------------------------DGSC VK--SPYT---EP--RPTGCIPATATFDASFEMGI---GENSLQANLWNI D--TPKLN--------MQEAISVT---GSCIPVQIQ--RN---------- -----------------------------------VKTAV---GKTHK-A LSIVHAEIEIVDK-DLFTIPD-TCKTSDQ-----------EATLNLQDLP LPAFMFMNLE---------------------------------------- -------------------------------------------------- ------------------------------------- >Pladu_comp2262137_c0_seq4 ------------------------------------MKSLLVFLGLVSVS LAAI-------IGVRQEKESAPA---RCC-VPKTM------------QIN VFGAE-----------FYETSKPYL-VPIIATYGGKINEGLAA-----LK IYDEKTRQLLR-HDIMDFNKQ--VMYNISA-------------------- -------------------------------------------------- ----------------------------------------------DGSC VK--SAFK---SP--QPSGCIPDSAVFDASFTMGI---GENSLVGNIWYY K--DASRN--------LEETVSVT---GSCIPILLQ--QN---------- -----------------------------------TNIDG---GKTHK-G VSYVHAEMEIIDK-DLFTIPD-TCKASNE------------EKMLIPQGL PVPFFMLMPVE--------------------------------------- -------------------------------------------------- ------------------------------------- >Pladu_comp2262137_c0_seq3 -------------------------------------------------- ----------------------------------M------------QIN VFGTE----------------FFDT-AKPWIRPMIATYGGKINEGLSALK LYKGTPDNFLR-QDIIDYNQK--VVYNIS--------------------- -------------------------------------------------- ---------------------------------------------ADGSC LK--SPFT---TP--QPSGCIPANATFESSFEMGI---GENSLQGNLWRY P--DDGLA--------LAVDNVAV--TRTCIPIQLQ--QI---------- -----------------------------------APLDD---GTFYK-G VSYIHAEREIIDK-DLFTIPD-TCETSNE-----------EVFLKPHDWP LPAFMFMDLK---------------------------------------- -------------------------------------------------- ------------------------------------- >Pladu_comp2277945_c0_seq2 -------------------------------------------------- ------------------------------MPQTLQ-----------MGF LGTVF-------------FDYAPAP-PFQWMRSIYASKPGFAG-----MK YFDRLSGKLQR-RVVIDYKNE--LAYLI---------------------- -------------------------------------------------- ---------------------------------------------NSEGC VK--QPFK---QP--QSSGCLRSSAKLVGDYRIGN---GLDSLDGFTYQY T---NAAK--------LKENMSVT---KNCIPIHWD--TK---------- -----------------------------------MATAK---GLLYQ-N GGAINPSYEVTEK-GIFDFPS-SCKT-EN-----------GPFDIATNLF PLPAFMIMDME--------------------------------------- -------------------------------------------------- ------------------------------------- >Pladu_comp2263873_c0_seq9 ------------------------------------MKSLIVFLGLVSLS YGSA---------IWSKNQVKDP---ACC-VPSPF------------QMT FIGEQ-----------LFDYPGAAV-PFHEMLAIYASQDGIAG-----VK YLDRYSGKLQE-RVVIDYKNG--YIYNV---------------------- -------------------------------------------------- ---------------------------------------------TSGGC VK--QPFK---EA--QPSGCLPDDAKWVGEYRMGN---GLDSMYGYTFQF A--DPSKK--------LQEDLSVS---KNCIPIHLQ--KT---------- -----------------------------------VTNGQ---GAVVQ-N GGIVNPSLKITEK-GIFDIPG-SCSTLEA-----------GRSDFKTYLL PFPSFVF------------------------------------------- -------------------------------------------------- ------------------------------------- >Pladu_isotig10568 ------------------------------------MNSLLVLLGLVSLS YGSA---------IWSKNMVKDP---ACC-FQRPG------------QFT FLGEV-----------LYNYAGAAV-PFQQMMAVYATKDGIDG-----VK YFDRKSGKLTS-RAVIDFKNG--FIYRINE-------------------- -------------------------------------------------- ----------------------------------------------GGEC VK--QATK---AK--QQSGCMPASAKWVGEYRVGN---GLDSIYGYTFQF G--EPSKN--------LAETLSVS---KNCVPLHVE--KT---------- -----------------------------------VTDAQ---GAIIQ-N GGIINPSLKITEK-GIFDIPA-TCNSVEA-----------GSFDFKAELL PVPSFLAPDME--------------------------------------- -------------------------------------------------- ------------------------------------- >Aplysia_XP_012941522.1 ----------------------------------MAACVTWFWGWLVGVC VAGA--------------VLGQT---PCC-WSDKW------------EAN LSQKL--------GVYNRVSNFASL-AQIEGTMSVDHSLQKTY----NDI RVTNGSSSTYL-KVLDDFANG--KSYTV---------------------- -------------------------------------------------- ---------------------------------------------YNGYC IK--VNLT---TP--MPASCVPAKARLLGNHSFSG-------VQAQTWVV P--APAYP---VTSDYNSSRITVS--EKGCVPLHEVALQF---------- -----------------------------------ADTSR------MS-V LSLQNLTPGIVDP-SVFDIPL-SCNTSRT---YHSLRDVTDSSPHMHVVG QYLHRHKTHLL--------------------------------------- -------------------------------------------------- ------------------------------------- >Diplosoma_CN499911.1 -------------------------------------MKLLGLFAFALII AASE----------------------SCE-APRRW------------TAL GLSFD----------------YSLR-FFSRGRIFYDAENERVR----YIT RIDFNSTKDLV-DNIYLFKEK--TYYRYDA-------------------- -------------------------------------------------- ---------------------------------------------ITDKC EK--KATP---RN--FIPVEVEKDSTFVGEAWIGLNGAPDEGISTQAYRH E--SSERV----------REQVFT--TQLCLPVSDS--IF---------- -----------------------------------GTLDG---IEVHE-H FQYFDIS-DLHHPDEAFKLPE-KCAML----------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Tetraodon_CAG02934.1 ----------------------------------MGKMYAAATLFVLMCL AAAT-------------HADHHH---PCH--PPDL------------TGF MSVLS----------------MKGE-VKAYGAITYDSTANKLR---FRSN ESQPTNGSLGL-DLLMFFNEG--IFYEIDS-------------------- -------------------------------------------------- ---------------------------------------------KNESC EK--KKLH---CS--MHPLDIPDGAKFHGLMSAGNPSINGEGLKVNIWTG Q--MPDSK--------GYYSTSVT---MGCLPVTTM--YF---------- -----------------------------------TDTSS-------F-I FSVMEIENEIKDP-GLLVVPS-VCQGQPL-----------EETPEGTVNS FLSEFM-------------------------------------------- -------------------------------------------------- ------------------------------------- >Takifugu_AL837040.1 ----------------------------------MGKMYAAAPLLVFICL AAAT------------HADHHHH---PCH--PPNV------------TGF MSVLS----------------MKGE-VKAYGAITYDSTANKLR---FRSN ESQPTNGSLGL-DLLMFFNEG--IFYEIDS-------------------- -------------------------------------------------- ---------------------------------------------KNESC EK--KKLH---CS--MHPLDVPDGAKFYSLMSAGNPSINGEGLKVNIWTG Q--IPDSK--------GYYSASVT---MGCLPLSSF--YF---------- -----------------------------------TESGS-------F-L FSLMEIENEIKDP-DLLVVPS-ICLGQPL-------------EET----- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Esox_P32188.1 -----------------------------------MQAFAVAALSIWLCL GATT--------LAESLAQSHGP---QHC-TSPNM------------TGV LTVMA---------------LNGGE-IKATGHYHYDTTDKKLR----FTE SDMHLNKSEHLEDYLMLFEEG--VFYDIDL-------------------- -------------------------------------------------- ---------------------------------------------KNQSC RK--MSLQ---SH--AHALELPAGAVHQVELFLGSDTVQEENIKVNIWMG S--VPETK--------GQYSVSTT--VGDCLPLSTF--YS---------- -----------------------------------TDSIT-------L-L FSNSQVVTEVKEP-EVFSLPS-FCEGLEL---------------EDTHND FFSIFNT------------------------------------------- -------------------------------------------------- ------------------------------------- >Oncorhynchus_P28770.1 -----------------------------------MQAFAVAALSIWLCL GATT-----------LAESHGPQ---HCT-SPN-M------------TGV LTVLA---------------LTGGE-IKATGHYSYDSTDKKIR----FTE SEMHLNKTEHLEDYLMLFEEG--VFYDIDM-------------------- -------------------------------------------------- ---------------------------------------------KNQSC KK--MSLH---SH--AHALELPAGAAHQVELFLGSDTVQEEDIKVNIWTG S--VPETK--------GQYFLSTT--VGECLPLSTF--YS---------- -----------------------------------TDSIT-------L-L FSNSEVVTEVKAP-EVFNLPS-FCEGVEL-----------EEAPEGQKND FFSLFNSV------------------------------------------ -------------------------------------------------- ------------------------------------- >Salmo_P28772.1 -----------------------------------MQDFAFAALSIWLCL GATA-----------LAESHGPQ---HCT-SPN-M------------TGV LTVMA---------------LTGGE-IKATGHYSYDSTDKKLR----FTE SEMHLNKTEHLEDYLMLFEEG--VFYDIDM-------------------- -------------------------------------------------- ---------------------------------------------KNQSC KK--MSLH---SH--AHALELPAGAAHQVELFLGSDTVQEENIKVNIWMG S--VAETK--------GQYSVLTT--VGECLPLSTF--YS---------- -----------------------------------TDSIT-------L-L FSNSEVVTEVKAP-EMFTLPS-FCEAVEL-----------EETPKGQKND FFNIFNTV------------------------------------------ -------------------------------------------------- ------------------------------------- >Oncorhynchus_P28771.1 -----------------------------------MQDFAFAALSIWLCL GATA-----------LAESHGPQ---HCT-SPN-M------------TGV LTVMA---------------LTGGE-IKATGHYSYDSTNKKLR----FTE SEMHLNKTEHLEDYLMLFEEG--VFYDIDM-------------------- -------------------------------------------------- ---------------------------------------------KNQSC KK--MSLH---SH--AHALELPAGAAHQVELFLGSDTVQEDNIKVNIWMG S--VAETK--------GQYSALTT--VGECLPLSTF--YS---------- -----------------------------------TDSIT-------L-L FSNSEVVTEVKAP-EMFTLPS-FCEAVEL-----------EETPKGQKND FFNIFNTV------------------------------------------ -------------------------------------------------- ------------------------------------- >Clupea_P32187.1 -----------------------------------MRLTGLLCVALWSAS AVVL---------------AEHQ---PCR-PPPQT------------HGN LWVTA----------------AKGA-PASVGEFNYDSQARKLH----FKD DALHVNKTDHL-EMLIFFEEG--IFYDIDS-------------------- -------------------------------------------------- ---------------------------------------------HNQSC HK--KTLQ---ST--YHCLEVPPNATHVTEGYLGSEFIGDQGVRMRKWRK R--VPELD--------GVVTVATT--SCGCVTLFAT--LF---------- -----------------------------------TDSND------VL-V FNFLDVEMKVKNPLEVFVPPS-YCDGVAL-----------EEEGDTFFGL FH------------------------------------------------ -------------------------------------------------- ------------------------------------- >Danio_P17561.2 ------------------------------------MHTVKLLCVVFSCL CAIG----------WASHHSHRQ---PCH-SPQLT------------SGT MKVVS----------------TGGH-DLASGEFSYDSKTNKFR----FVE DTTHANKTSYM-DVLIHFEEG--VLYEIDS-------------------- -------------------------------------------------- ---------------------------------------------KNESC KK--ETLQ---FR--KHLMEIPVDATHESESYMGSPSLTEQGLRVRVWNG K--FPELH--------AHYSLSTT--SCGCLTVSGS--YY---------- -----------------------------------GEKKD-------L-F FSFFGVETEVDDL-QVFAPPA-YCEGVSF-------------EEAPDDHS FFDLFHD------------------------------------------- -------------------------------------------------- ------------------------------------- >Notemigonus_Q91130.1 ------------------------------------MHTVKLLCVVFSCL CAVA------------WASSHRQ---PCH-SPPLT------------SGT MKVVS----------------TGGH-DLASGEFSYDSKASKFR-----FV EDTHANKTSHM-DVLIHFEEG--TLYEIDS-------------------- -------------------------------------------------- ---------------------------------------------KNESC KK--ETLQ---FR--KHLMEIPPDATHESEIYMGSPTVIEQGLRVRVWHG K--LPELH--------AHYSLSTT--SCGCLPVSGS--FY---------- -----------------------------------GKKKD-------L-L FSFFGVEPEVDDP-QAFVPPA-YCEGVSF-------------EEAPDDHS FFDLFHD------------------------------------------- -------------------------------------------------- ------------------------------------- >Carassius_P13506.2 ------------------------------------MHTVKLLCVVFSCL CAVA------------WASSHRQ---PCH-APPLT------------SGT MKVVS----------------TGGH-DLESGEFSYDSKANKFR----FVE DTAHANKTSHM-DVLIHFEEG--VLYEIDS-------------------- -------------------------------------------------- ---------------------------------------------KNESC KK--ETLQ---FR--KHLMEIPPDATHESEIYMGSPSITEQGLRVRVWNG K--FPELH--------AHYSMSTT--SCGCLPVSGS--YH---------- -----------------------------------GEKKD-------L-H FSFFGVETEVDDL-QVFVPPA-YCEGVAF-------------EEAPDDHS FFDLFHD------------------------------------------- -------------------------------------------------- ------------------------------------- >Devario_Q90399.1 ------------------------------------MHTVKLLCVVFSCL CAVA---------WGSSHVSNRQ---PCH-SPQLT------------SGT MKVIS----------------TGGH-DLASGEFNYDSKANKFR----FVE DTTHANKTSYM-DVLVHFEEG--VLYEIDS-------------------- -------------------------------------------------- ---------------------------------------------KNESC KK--ETLQ---FR--KHLMEIPPDATHESEIYMGSPSITEQGLRVRVWNG K--LPELH--------AHYSLSTT--SCGCLPVSGS--YY---------- -----------------------------------GEKKD-------L-F FSFFGVETEVDDP-QVFVPPA-YCEGVSF-------------EEAPDDHS FFDLFHD------------------------------------------- -------------------------------------------------- ------------------------------------- >Carassius_P12958.2 ------------------------------------MHTVKLLCVVFSCL CAVA------------WASSDRQ---PCH-SPPLI------------SGT MKVVS----------------TGGH-DLASGEFSYDSKANKFR----FVE DAAHANKTSHT-DVLVHFEEG--TLYEIDS-------------------- -------------------------------------------------- ---------------------------------------------KNESC KK--ETLQ---FR--KHLMEIPPDATHESEIYMGSPSITEQGLRVRVWSG K--LPELH--------AHYSLSIT--SCGCLPVSGS--YY---------- -----------------------------------GDKKD-------L-L FSFFGVETEVDDL-QVFVPPA-YCEGVAF-------------EEAPDDHS FFDLFHD------------------------------------------- -------------------------------------------------- ------------------------------------- >Cyprinus_P38528.1 ------------------------------------MHTVKLLCVVFSCL CAVA------------WASSNRQ---PCH-SPPLT------------SGT MKVVS----------------TGGH-DLASGEFSYDSKANKFR----FVE DTAHANKTSHM-DVLVHFEEG--VLYEIDS-------------------- -------------------------------------------------- ---------------------------------------------KNESC KK--ETLQ---FR--KHLMEIPPDATHESEIYMGSPSITEQGLRVRVWNG K--LPELH--------AHYSLSTT--SCGCLPVSGS--YY---------- -----------------------------------GDKKD-------L-L FSFFGVETEVDDP-QVFVPPA-YCEAVAF-------------EEAPDDHS FFDLFHD------------------------------------------- -------------------------------------------------- ------------------------------------- >Rhamphichthys_AAB40067.1 -------------------------------------------------- ----------------------------M-----I------------SGT LTVRS----------------SGGH-TVATGEFNYDSTGKKLH----FLE KNDDSNKTSHI-DVLIHFEEG--VIYELDS-------------------- -------------------------------------------------- ---------------------------------------------KNESC KK--QTLK---SR--KHPMELPADASHDSEVYLGSLVVPEQGLRLRVWTG K--LPDLH--------AQYTMLTT--SCGCLTVSCY--YH---------- -----------------------------------SDKTD-------L-I FSFLDVETHVDDP-QVFVPRP-TCDGA----------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Distichodus_AAB40058.1 -------------------------------------------------- ----------------------------M-----T------------SGT LTVCS----------------TGGH-TVASGDFSYDSTAKKLR-----FV EDNHSNKTSHM-DVLIHFEEG--LMYELDS-------------------- -------------------------------------------------- ---------------------------------------------KNESC KK--HTLQ---SR--KHPMELPADASHENEMYLGSPSISEQGLRLRLWSG K--LPDLH--------AQYSMWTT--SCGCLTVSCA--YH---------- -----------------------------------AEKND-------L-I FSFFKVETEVNDS-QVFVPPA-YCDGVES-------------DP------ -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Gymnocorymbus_AAB40053.1 -------------------------------------------------- ----------------------------M-----T------------SGT LNVFS----------------TGGH-DIAHGDFSYDSTAKKLR----FVE SESHSNKTTHM-DVLIHFEEG--ILFEIDS-------------------- -------------------------------------------------- ---------------------------------------------KNQSC KK--ETLK---YR--RHPMELPSDATHERETYLGSPSKSEQGLRVRMWDG K--LPDLH--------ANYTMLTT--SCGCLTVYCC--YH---------- -----------------------------------SEKTD-------L-T FSFMNVETEVDDT-QVFVPPA-YCEGVA---------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Hemiodus_AAB40060.1 -------------------------------------------------- ----------------------------M-----T------------SGT LGVTS----------------TGGH-DIAEGXFNYDSTAKKLR----FVE NESHANKTSHM-DVLIHFEEG--VLYEIDS-------------------- -------------------------------------------------- ---------------------------------------------KNESC KK--QTLK---YR--RHPIELPSDAHHESETYLGSPSKSEQGLRVRSWNG K--LPDLH--------ANYTMLTT--SCGCLTVSYC--YH---------- -----------------------------------SEKTD-------L-I FSFMNVEPEVDDS-QVFVPPA-YCDGVGF-------------DDD----- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Alestes_AAB40052.1 -------------------------------------------------- ----------------------------M-----T------------SGV LSVTS----------------TGGH-DIAVGDFNYDSTAKKLR----FVE NDSHSNKTTHM-DVLIHFEEG--VMYEIDS-------------------- -------------------------------------------------- ---------------------------------------------KNESC KK--ETLK---YR--RHPMELPSDAHHESETYLGSPSKSEQGLRVRSWNG K--LPDLH--------ANYTMLTT--SCGCLTVSCC--YH---------- -----------------------------------SEKID-------L-T FSFMNVETEVDDA-QVFVPPT-FCEGV----------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Chalceus_AAB40057.1 -------------------------------------------------- ----------------------------M-----T------------SGM MSVTS----------------TGGH-DIAVGDFNYDSTAKKLR----FVE NESHANKTSHM-DVLIHFEEG--VLYEMDS-------------------- -------------------------------------------------- ---------------------------------------------KNESC KK--QTLK---YR--RHPMELPSDATHESETYLGSPSKSEQGLRVRSWNG K--LPDLH--------ANYTMLTT--SCGCLTVSCC--YH---------- -----------------------------------SEKTD-------L-A FSFMNVKTEVDDS-QVFVPPA-YCDGVALE-------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Leporinus_AAB40063.1 -------------------------------------------------- ----------------------------M-----T------------SGT LSVTS----------------TGGH-DIAEGEFNYDSTAKKLR----FVE NESHSNKTSHM-DVLIHFEEG--VLYEIDS-------------------- -------------------------------------------------- ---------------------------------------------KNESC KK--QTLK---YR--RHPMELPSDAHHESETYLGSPSKPEQGLRVRSWNG K--LPDLH--------ANYTMWTT--SCGCLTVTCC--YH---------- -----------------------------------SEKTD-------L-I FSFMNVETEVDDS-QVFVPPA-YCDAGAL-------------EE------ -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Nannobrycon_AAB40065.1 -------------------------------------------------- ----------------------------M-----T------------SGT LTVCS----------------TGGH-TVASGDFSYDSTAKKLR-----FV EDNHSNKTSHM-DVLIHFEEG--VMYEIDS-------------------- -------------------------------------------------- ---------------------------------------------KNESC KK--QTLK---YR--RHPMELPSDAHYESEAYLGSPSKSEQGLRVRTWNG K--LPDLH--------ANYTMLTT--SCGCLTVSCC--YH---------- -----------------------------------SEKTD-------L-T FSFMNVETEVDDA-QVFVPPA-YCDGV----------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Metynnis_AAB40064.1 -------------------------------------------------- ----------------------------M-----T------------SGT LSVSS----------------TGGH-DIADGEFNYDSTAKKLR----FVE NESHSNKTSHM-DVLIHFEEG--VLYEIDS-------------------- -------------------------------------------------- ---------------------------------------------KNESC KK--QTLK---YR--RHPMELPSDAHYESEAYLGSPSKSEQGLRVRTWNG K--LPDLH--------ANYTMLTT--SCGCLTVSCC--YH---------- -----------------------------------SEKTD-------L-T FSFMNVETEVDDA-QVFVPPT-YCDGVAL-----------ETP------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Ictalurus_BE212610.1 ------------------------------------MRTIELFCVAFLCL SPMA------------WVSSSRE---PCR-SPAKT------------KGL LSVTS----------------AKDD-TTVWGDFKYDAAKKYLR-----FV EDSKSNRTSHL-DVLVHFEQD--VIYEFDS-------------------- -------------------------------------------------- ---------------------------------------------KNDSC KK--QSLP---SH--SHPLEVPADATHQDELYLGSLDKSEQGLRVRIWSG N--ISDHL--DTHHSQAHYSIITT--SCGCVPVSCI--YH---------- -----------------------------------SETYD-------L-I FKFFNVEIDFDEI-QAFKLPD-TVTVCFR-----------GG-------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Schilbe_AAB40068.1 ------------------------------------------------GS SSRE----------------------PCR-SPPKT------------SGT LCVSS----------------SKDD-AIAWGEFKYDSSQKHLR----FVE DTGKSNKTSYL-DVLIDFDKG--VLYELDT-------------------- -------------------------------------------------- ---------------------------------------------KNESC RK--QMLP---SH--KHPLELPSDATHVEELYLGRLDKTEQGLRVRLWSG N--LSDHDAHHADHVQAHYSMTTT--SCGCIAVSYT--YH---------- -----------------------------------SEKND-------L-V FSFYNVKARVDDS-QAFTPPR-YCEGLTT-------------EDA----- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Synodontis_AAB40069.1 -----------------------------------------------LGS SDRE----------------------PCR-SPSKT------------SGT VCVSS----------------TKDD-TIAWGEFKYDSTHKRLR----FVE DCSKSNKTSHL-DVLIHFEEG--VLYELDP-------------------- -------------------------------------------------- ---------------------------------------------KNESC KK--EPLP---SH--KHPLEVPSDATHMDELYLGSPDKSDQGLRVRLWSG N--ISHHN---PDHTPDHYSITTT--SCGCITVSCT--YH---------- -----------------------------------GEKND-------L-I FSFYNVKTEVDDM-QVFNPPD-YCDDLE---------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Squalus_CV547772.1 ----------------------------------MKPLAALSVCSLFFLL AEGG----------------KPQ---PCS-TPSLL------------EGR MAIFS----------------SNKG-YNDFGKFSYDANGKRIY----VDR VMMTGVDERIIVEDLFLFRES--VMFQFYP-------------------- -------------------------------------------------- ---------------------------------------------QNRTC VK--LPLR---VP--FQKFIVPQNATYLGQIYLGGSSEPGQGLLANTWSG D--IGSGH----------YALTVT--EFGCLPLSEV--YY---------- -----------------------------------SKETN------WI-I ESFYDMTMGISES-NVFIPPP-ECAYLN---------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Oncorhynchus_BX073953.3 ------------------------------------MQAYLLFSISLCLA VGSL--------------AERPH---PCK-SPPLV------------EGS MALTI----------------LKEK-TFGVEKFSYDAFEERVH----IRL LLDQDNHTTYR-DTLLLYKEG--IAYQIFR-------------------- -------------------------------------------------- ---------------------------------------------HNQTC EK--VHFK---DP--WKPMEIPRDAKFQSQVIIGSLSAPAEGLLVNNWSG T--MAEPH--------DDYLLTFT--EFGCLPVHAW--WY---------- -----------------------------------NIEDQ-----TLL-S LSFFDMVLGVEDP-EVFNPPS-FCDKAQP-------------GNDAALTS FFDALI-------------------------------------------- -------------------------------------------------- ------------------------------------- >Latimeria_XP_005988944.1 ---------------------------------MKALTALLTFGFLFLLT DGQK-----------------PK---PCE-GPLLL------------EGQ FVVMD----------------SSKK-SVVMGKFSNDTILQRSR--VV-EE IFLEPNKTIKT-EKILLYNMS--TMYTINL-------------------- -------------------------------------------------- ---------------------------------------------ETKSC NK--THLD---TP--FRKIEVPKDAEFVSQLVFGGSSDPREGLLVNIWKG T--EHEFG--------GYYQVSVT--EFGCLPLSTL--YL---------- -----------------------------------SEKTS------WV-I TSYLNLTEGIEDP-NVFVPPS-FCNT------------------------ -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Danio_XP_685579.4 -----------------------------------MKIVILAVVCLTLSI HAQK-----------------PE---PCK-SPPLL------------EGA LTVFL----------------PSQH-WRVFEKFSYDAIGQNVR----VLA AGTDGNQTFLT-DLLLLYREG--VSYEIHY-------------------- -------------------------------------------------- ---------------------------------------------RNQTC IK--QALK---EP--FRHLGVPHNAHFLSQMVLGSSSLPGQGLLVNVWNG T--WEETK--------SHYLMTYT--EFGCIPVSIA--DF---------- -----------------------------------TQKAE-----LGE-L TSFFDLVEGIENP-DVFIPPS-FCDSVEV-----------LPPRKSASSS FIPVL--------------------------------------------- -------------------------------------------------- ------------------------------------- >Danio_NP_001280631.1 -------------------------------MMKLLLLFVAPLLFLTVCC SAQR-----------------PH---QCH-SPPLL------------SGS LSVSA----------------RDGQ-DWAVAKYRYDAFGQRIR----LWE FGEVDSKSFHL-NMLFLFREG--VVYSMNY-------------------- -------------------------------------------------- ---------------------------------------------KNETC QK--NALH---SS--FHPSRIPRNATLLAQVILGGSSAPGEGLLVNTWTG D--VPETQ--------GKYVATVT--EFGCIPVSTS-------------- -------------------------------------------------- --LLHRTDRLGHH-HLF--------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Oryzias_BJ494809.1 -----------------------------------MKLAVVLACFVVFCL AEKP-------L--------------PCT-SPPLL------------TGR LTVTT----------------QNEK-IGIFGKYLYDAVGQRVR----LFD IGSFKNQTFTA-DVLLHFTEA--AMYEIDD-------------------- -------------------------------------------------- ---------------------------------------------AKRTC KK--SPLK---AD--FQPLKIPQDAFLLSQTVVGSSSVPGQGLLVNNWYG K--LPDKS--------XDFLSTVT--ELGCIPVKSS-------------- -----------------------------------YQTKE-----FWM-- --------------GVSRLLX----------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Oryzias_AU180189.1 ------------------------------------MRALVLLVCFSACC LAQR-----------------PQ---PCL-SPPLM------------TGF LSVNT----------------QNEK-LTAYAKYFYDAFGKRIR----LKE VGTYANQSFHF-DALLLFRKG--VLYKINH-------------------- -------------------------------------------------- ---------------------------------------------KNQTC TK--KRLG---AC--FHPLAVPRNATLLGQAVLGGSSGPGQGVLVNTWTG QVHMKNRT--------AEYISTVT--EFGCIPISTL--YH---------- -----------------------------------TNKNG------WM-V TSFFNNVIGLTDP-EELIPPS-FCENAIL------------DEEEEEPAT FYSL---------------------------------------------- -------------------------------------------------- ------------------------------------- >Fundulus_XP_012716956.1 -----------------------------------MRLLVLLTCLLAACL AEKP-------H--------------PCA-SPPLL------------SGA LTVST----------------QNEK-LWTYARYLYDALGHRVR----LLE LGTYQNKSFTY-DALLLYREA--AMYEIHA-------------------- -------------------------------------------------- ---------------------------------------------HNRTC QK--KPLK---VE--FHPMAVPKDASLLGQAVLGSSSGPGQGLLVNTWTG D--LPDKS--------GKYMTTVT--EFGCIPVSTA--YH---------- -----------------------------------TKEFG------WV-V TSFFNNVIGVEDP-DLLNPPS-YCSDAEI-----------KEEEPADFLS LFMSKI-------------------------------------------- -------------------------------------------------- ------------------------------------- >Tetraodon_CAF88218.1 -----------------------------------MKVFLALAGLLATCL AQKP----------------------RVCTSPPFL------------TGQ LTVST----------------QNEK-VWAFAKYKYDALGKRFR----ITE QGVYANKSFTI-DVLLLYRKG--VMYEIDR-------------------- -------------------------------------------------- ---------------------------------------------KNRTC KK--SPLK---TD--FHPLAIPKDANLLGQAILGSSSGWGQGLLVNTWMG D--LPEGG---------KYISTVT--QFGCIPISTA--VQ---------- -----------------------------------TSQFG------WI-L TSFFDNVIGITDP-NCLNPPS-FCPDEFE-----------AGAEPRDFLS LFQTAH-------------------------------------------- -------------------------------------------------- ------------------------------------- >Ciona_AK174156.1 --------------------------------------MKFFLLVALFGL TYAQ-----------------DP---RCA-APGYF------------QAR VRSYD----------------HETN-YFRDGRFSYDAHEQRVR----MVE VLQENATRPQR-DELILHREK--KRYVVDL-------------------- -------------------------------------------------- ---------------------------------------------HTRKC NV--STVD---FH--FHPISVDEPARFLGYSIVGTLDEPEMGMMVGSWHH RSEGNDIR--------GNLTQSFT--RDECIPVSEV--FY---------- -----------------------------------GETVK-DHQMLHF-H RTYFDVTLGLNSA-NVFDIPK-ECIHRK---------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Ciona_tr_F6T7K5_XP_002128930.1 -------------------------------------MKLLVLFSFFACV ALAA----------------AQT---PCV-SPGVF------------EAK AYAFD----------------HHER-NFVIGKISYDENQERVR----LVD AEYENSNLGQY-DTLYAFKEK--TQYRVDM-------------------- -------------------------------------------------- ---------------------------------------------KTKEC TK--SPLT---GD--YFPFGIFPKSTYTGSFILGSLSGPGTGVIVQEWYY K--NADGG--------SVWVQLYT--EHGCLPIQAI--FI---------- -----------------------------------GHDSA--GEEIDY-H YEYMDVTLGVQDP-AVFDVPK-ECL------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Saccoglossus_tr_D2XMR9_NP_001164689.1 ------------------------------------MKLVLALLCVVGVV YGQV-----------------PR---PCL-APPLW------------EGK IVEID----------------PSKK-FETRARVAYDAYNERFH----SIE EVNLNDKKEFY-SSLFLHKER--KEYNLNL-------------------- -------------------------------------------------- ---------------------------------------------KTGKC TS--KELT---RP--FHYIGIPENATFYGETIIGSLSAPGEGVTVQLWGG T--TSEGS---------RYAGTWT--VRGCIPVHDS--YF---------- -----------------------------------SEHTG------FI-S TSFFDVVAGIHDP-EVFIPPK-ECL------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Branchiostoma_AAT39416.1 ------------------------------------MKTLLLFVAVCVTV AYSQ----------------VLE---PCS-APPLW------------EAR VSRFD----------------PEKR-FSERARMSYDSTNRRVR----RIE EVNLLEQRDFY-DVLYIHNTEPGTEYRLNL-------------------- -------------------------------------------------- ---------------------------------------------KTKEC EK--RELS---EP--WRAFQVPPNSTFLGESYIGTGAVPGAGVLTELWSN T--FESGD---------KYFGAYT--VEGCIPIQEE--FY---------- -----------------------------------SNRTG------LV-S TFXFDVVAGISDP-XVFIPPR-ECM------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Lottia_tr_V4A507_XP_009059162.1 ------------------------------------MLRWLVCFSLLVCV MSQT-----------------PR---PCE-SPKAW------------EGD VHTFD----------------ESKK-FRRNARITYDEENIRIR----EVE ELAIGSKDDFF-DVIRLYREG--VEYRLNL-------------------- -------------------------------------------------- ---------------------------------------------RTKVC NV--TTLT---RH--FVPIGFPPNANFSDSFVIGISGFQDEEVSAISFDG V--FEGVQ----------FYGIVT--TPDCYPVHLT--TQ---------- -----------------------------------SQQFG------LA-Q SQYYNIKAGIPDP-NVFIPPP-ECTRK----------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Lottia_tr_V4A0A4_XP_009059164.1 -------------------------------------MKYLLLALTVTAV AGQL-----------------PL---PCT-SPRQF------------ESR FARFD----------------REKN-FQEFAKVSYDEDQKRVR----EIE EVAIGSTKDYY-DVLYLHNIG--IEYRFNL-------------------- -------------------------------------------------- ---------------------------------------------RTRKC NV--TTIS---KT--FIPFSVPGFAKFAGQGNIGVAGFTNEHVDIQLFEG K--TPEGH---------PLFISVT--SPDCFPVNFG--YY---------- -----------------------------------SPTVG------YD-H RNFYDVTVGIRDP-NVFIPPS-ECIQ------------------------ -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Haliotis_tr_B6RB49_ABO26653.1 ------------------------------------MFTVASLCLLATVA LAQE-----------------PH---PCE-SPRQF------------EGR FSIYD----------------NDRN-FRAFGRFAYDETNRRFR----ETE EMEIGRDREYF-DRLYLHNLN--LEYRMDL-------------------- -------------------------------------------------- ---------------------------------------------RTRNC TV--STLT---RP--FIPFAVPQDARFRGEGVIGVSGIPDEHVTIANFDG T--TDGNP----------YFIIAT--VEDCVPVTAG--FY---------- -----------------------------------SNRTG------GV-L RQFYDITLGLRDP-DAFIPPQ-ECHTV----------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Lottia_tr_V4A9W0_XP_009059163.1 ------------------------------------MKVLLVFCVAVVSV LSQT-----------------PN---PCV-SPKQW------------EGR LFRYD----------------RSKN-FLQRARISYDELDRRVR----EVE EIEIGQTRDYY-DVLYLHNIG--IEYRLNF-------------------- -------------------------------------------------- ---------------------------------------------RTKNC TI--TPLT---RP--FIPAGLPEDAKYRGEATIGPAGVPDEHLTAVLFDG E--FEGNP----------YFGAVT--YPSCAPIETG--FY---------- -----------------------------------SNRTG------TV-H STYFDITLGITDP-SVFIPPS-ECTS------------------------ -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Aplysia_tr_A1XP46_ABF18970.1 -----------------------------------MKFLVAFFVLFVACV YANR----------------------PCS-APHEL------------TFR ASRWN----------------YGET-YYERFFGEYDRFNKRVV----LFE EDFESGTKKQR-ELLFLHKEG--VGYDFNL-------------------- -------------------------------------------------- ---------------------------------------------QSKHC KK--FKV----GA--FKPFEVPSGATYEGEFSIGG---PTEEVTIDRWSD K--ISSRR--------EHWIGEFS--LKTCYPISQ---FM---------- -----------------------------------IEEGN---FNKTS-F TFFYDTVKGIVNP-NDFNVPK-ECEKSAI-----------EVDMPINARL AKAMYSGTLHD--------------------------------------- -------------------------------------------------- ------------------------------------- >Lottia_tr_V4CIC5_XP_009058449.1 ------------------------------------MKIVIIVLAMATVA WAQL-----------------PS---PCI-TPLEM------------TFR ANQYN----------------HEDD-IFNRYFIAYDAINKRQA---IFEE ENVIIPGRQFH-EFLILNNEN--VMYDYNL-------------------- -------------------------------------------------- ---------------------------------------------KTKTC TK---SIP---RP--WRNFAIPPNATFENEFSIGG---PSEMVYAQEWSD R--IPFRQ-------REMWLGVFS--LKDCYPIREV--VI---------- ------------------------------------ANSN---ITQTI-T TNFYDIVQGITNP-DDFIPPT-ECLNAEW-----------AKPSRYFY-- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Holothuria_AAR89380.1 ------------------------------------MNKLILLSVVVAVA TGIN--------VSPSTGVEQKA---PCQ-TAEQW------------EGR ASEWD----------------HVQG-RNNRFLISFDGIGMRKR---VIEE KKSFMPGRRFY-EYIMEYKTN--KMYTINM-------------------- -------------------------------------------------- ---------------------------------------------NLGTC TV--STLK---QP--WQNHTIPSDATLEDEYEMGD---PGSGLNVQEWSD R--LPARR---SESWIGIYTPKTE--NGGCWPVVEV--FT---------- -----------------------------------DDTTD---PPVSL-T TRFFDITPGIKNM-SVFIPPP-SCNQNVE-----------IVVENVENSG PIYTFYNYIKSWF------------------------------------- -------------------------------------------------- ------------------------------------- >Leucoraja_CO050982.1 ------------------------------NGRLLARAGSAWLLVLLCCW WVPGSCVARPARGSGLEASAQPQ---PCQ-APQQW------------EGR AVVYD----------------HTTG-KNSRVLISYDGQNQRVR---ILDE KKGHIPCKKFY-EYIYLYKNP--VLFKIEQ-------------------- -------------------------------------------------- ---------------------------------------------VTKQC SK--LPLI---QP--WDPYDIPNNSTYEDHYSIGG---PGDQIVVQEWSD R--KPARK-------FETWVGIYT--VKDCYPVQET---Y---------- -----------------------------------AKSYN-----VTS-S TRFFDLQLGISDP-SVFTPPS-TCQAASP--------------EEMSDDC -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Tetraodon_CR664959.2 -----------------------------------MLRLVFVFLAAAAAS ALGL--------GGTGGSVRDAQ---PCV-APQQW------------EGR WVQYD----------------HSTG-RNRRAVVSYDGLKQRIR---VLQK HKKHTPCQRYF-EYIYLYKSQ--VMFQIDQ-------------------- -------------------------------------------------- ---------------------------------------------KTKDC SK--VALT---EA--WDPFDIPDNSTFEDQYIIGG---PGDNVEVQEWSD R--KPARQ-------HETWVGVYT--LKDCYPVQET---Y---------- -----------------------------------TKNSS-----VTT-S TRFFDLQLGISDP-GVFTPPS-TCQSARP--------------QRMLESC -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Danio_NP_001002416.1 -------------------------------------MLVFVVLWQVLCL SVCS------------GFRAAPQ---PCP-APLQW------------EGR TVEYD----------------HGTG-RNTRAAVSYDAQNQRIR---VLEQ KTGHTPCKKFF-EYIYLFKSG--VLFQIEE-------------------- -------------------------------------------------- ---------------------------------------------ITKQC AK--IALT---EA--WDPYDIPLNSTYEDQYFIGG---PGDMIEVQEWSD R--KPARK-------NEAWVGVYT--LKDCYPVQET---Y---------- -----------------------------------TKNSS-----VTT-S TRFFDLQLGISDP-EVFNPPS-TCLSALS--------------KRMTSDC -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Ochotona_XP_004582592.1 ----------------------------MPGHAPFLVVRGLLSAWLLSGL WVFS-----LSGLGLAGSLVTPP---PCQ-APQQW------------EGR QVVYQ----------------QSSG-HYSRALLSYDGLNQRVR---VLDE RKALIPCKRLF-EYILLYKDG--VMFQIEQ-------------------- -------------------------------------------------- ---------------------------------------------ATKQC AK--ISLT---DP--WDPLDIPQNSTFEDQYSIGG---PQEQIMVQEWSD R--KYARS-------YETWIGIYT--VKDCYPVQET---F---------- -----------------------------------TRNYS-----VLL-S TRFFDVQLGIKDP-SVFTPPS-TCQTAQM--------------ERMSEDC P------------------------------------------------- -------------------------------------------------- ------------------------------------- >Oryctolagus_XP_017199923.1 ----------------------------MPGRTPFRLARGVLSPWLLSCL WVWA-----LGGLCGLGSAGLPR---PCQ-APQQW------------EGR QVVYQ----------------QSSG-RNSRALLSYDGLNQRVR---VLDE RKALIPCKRLF-EYIFLYKDG--VMFQIEQ-------------------- -------------------------------------------------- ---------------------------------------------ATKQC SK--ISLT---DP--WDPLDIPQNSTFEDQYSIGG---PQEQISVQEWSD R--KSARS-------YETWIGIYT--VKDCYPVQET---F---------- -----------------------------------TRNYS-----VLL-S TRFFDVQLGIKDP-SVFTPPS-TCQSAQT--------------ERMSEEC P------------------------------------------------- -------------------------------------------------- ------------------------------------- >Macaca_BAB01585.1 -------------------------MTAMPGRAPLHTVPGALGPWLLGCL WAWT-----LCGLCSLGAVGAPR---PCQ-APQQW------------EGR QVMYQ----------------QSSG-RNSRALLSYDGLNQRVR---VLDE RKALIPCKRLF-EYILLYKDG--VMFQIEQ-------------------- -------------------------------------------------- ---------------------------------------------ATKQC SK--MTLT---EP--WDPLDIPQNSTFEDQYSIGG---PQEQIMVQEWSD R--KSARS-------YETWIGIYT--VKDCYPVQET---F---------- -----------------------------------TKNYS-----VIL-S TRVFDIQLGIKDP-SVFTPPS-TCQIAQL--------------EKMSEDC SW------------------------------------------------ -------------------------------------------------- ------------------------------------- >Mus_AAK15787.1 ----------------------------MPGRAPLRTVPGALGAWLLSGL WAWT-----LCGLCSLGAVGAPR---PCQ-APQQW------------EGR QVMYQ----------------QSSG-RNSRALLSYDGLNQRVR---VLDE RKALIPCKRLF-EYILLYKDG--VMFQIDQ-------------------- -------------------------------------------------- ---------------------------------------------ATKQC SK--MTLT---QP--RDPLDIPQNSTFEDQYSIGG---PQEQITVQEWSD R--KSARS-------YETWIGIYT--VKDCYPVQET---F---------- -----------------------------------TINYS-----VIL-S TRFFDIQLGIKDP-SVFTPPS-TCQMAQL--------------EKMSEDC SW------------------------------------------------ -------------------------------------------------- ------------------------------------- >Homo_Q9UM22.2 ----------------------------MPGRAPLRTVPGALGAWLLGGL WAWT-----LCGLCSLGAVGAPR---PCQ-APQQW------------EGR QVMYQ----------------QSSG-RNSRALLSYDGLNQRVR---VLDE RKALIPCKRLF-EYILLYKDG--VMFQIDQ-------------------- -------------------------------------------------- ---------------------------------------------ATKQC SK--MTLT---QP--WDPLDIPQNSTFEDQYSIGG---PQEQITVQEWSD R--KSARS-------YETWIGIYT--VKDCYPVQET---F---------- -----------------------------------TINYS-----VIL-S TRFFDIQLGIKDP-SVFTPPS-TCQMAQL--------------EKMSEDC SW------------------------------------------------ -------------------------------------------------- ------------------------------------- >Ictidomys_XP_005319259.1 -----------------------------MSGRVPIRAASPLGAWLLGGL WVWA--LGGLCGLGTAGSPGSPH---PCQ-APQQW------------EGR QVLYQ----------------QSSG-RNSRALLSYDGLNQRVR---VLDE RKALIPCKRLF-EYILLYKDG--VMFQIEQ-------------------- -------------------------------------------------- ---------------------------------------------ATKQC SK--ITLT---EP--WDPLDIPQNSTFEDQYSIGG---PQEQITVQEWSN R--KSARS-------YETWIGIYT--AKDCYPVQET---F---------- -----------------------------------IRNYS-----VIL-S TRFFDVQLGIKDP-SVFTPPS-TCQTAQP--------------EKMSEDC TW------------------------------------------------ -------------------------------------------------- ------------------------------------- >Peromyscus_XP_006988964.1 ----------------------------MHAHAPRRVVRGPRGAWLLGGL WVWA-----VCGLCGLGTAGPPGTQQPCQ-APQQW------------EGR QVLYQ----------------QRSG-HNSRALLSYDGLNQRVR---VLDE RKALIPCKRLF-EYILLYKDG--VMFQIEQ-------------------- -------------------------------------------------- ---------------------------------------------ATKQC AK--ISLT---EP--WDPLDIPQNSTFEDQYSIGG---PQEQITVQEWSD R--KTARS-------YETWIGVYT--AKDCYPVQET---F---------- -----------------------------------IRNYT-----VVL-S TRFFDVQLGIKDP-SVFTPPS-TCQTAQP--------------EKMSEDC SW------------------------------------------------ -------------------------------------------------- ------------------------------------- >Mesocricetus_XP_012970158.1 --------------------------MAIHAHASCRVVWGPRGAWLLGGL WVWA-----LCSLCGLGTAGSPETPQPCQ-APQQW------------EGR QVLYQ----------------QSSG-HNSRALLSYDGLNQRVR---VLDE RKALIPCKRLF-EYILLYKDG--VMFQIEQ-------------------- -------------------------------------------------- ---------------------------------------------ATKQC AK--LSLT---EP--WDPLDIPQNSTFEDQYSIGG---PQEQITVQEWSD R--RTARS-------YETWIGVYT--AKDCYPVQET---F---------- -----------------------------------IRNYT-----VVL-S TRFFDVQLGIKDP-SVFTPPS-TCQTAQP--------------EKMSEDC SW------------------------------------------------ -------------------------------------------------- ------------------------------------- >Rattus_AAH83701.1 ----------------------------MLTRAPRRLVQGPRETWLLGGL WVWI-----LCGLGMAGSPGTPQ---PCQ-APQQW------------EGR QVLYQ----------------QSSG-HNSRALVSYDGLNQRVR---VLDE RKALIPCKRLF-EYILLYKDG--VMFQIEQ-------------------- -------------------------------------------------- ---------------------------------------------ATKLC AK--IPLA---EP--WDPLDIPQNSTFEDQYSIGG---PQEQIMVQEWSD R--RTARS-------YETWIGVYT--AKDCYPVQET---F---------- -----------------------------------IRNYT-----VVL-S TRFFDVQLGIKDP-SVFTPPS-TCQTAQP--------------EKMKENC SL------------------------------------------------ -------------------------------------------------- ------------------------------------- >Mus_AAK51799.1 ----------------------------MPARAPRRLVQGPRGTWLLGSL WVWV-----LCGLGMAGSLGTPQ---PCQ-APQQW------------EGR QVLYQ----------------QSSG-HNNRALVSYDGLNQRVR---VLDE RKALIPCKRLF-EYILLYKEG--VMFQIEQ-------------------- -------------------------------------------------- ---------------------------------------------ATKQC AK--IPLV---ES--WDPLDIPQNSTFEDQYSIGG---PQEQILVQEWSD R--RTARS-------YETWIGVYT--AKDCYPVQET---F---------- -----------------------------------IRNYT-----VVM-S TRFFDVQLGIKDP-SVFTPPS-TCQAAQP--------------EKMSDGC SL------------------------------------------------ -------------------------------------------------- ------------------------------------- >Taeniopygia_CK314830.1 -------------------MARPAAGRRQRPGPGPPLRLLLLLGVLLLRG AAAA---------------ARAE---PCQ-APRQW------------EGR TVFYE----------------HGSG-RNTRAAVTYDGPNQRLR---ILEE RKALIPCKKFF-EYILLYKDA--VMFQIEQ-------------------- -------------------------------------------------- ---------------------------------------------VTKLC SK--IALT---EP--WDPYDIPANSTYEDQYYIGG---PGDEVMVQEWSD R--KPARK-------LESWVGVYT--VKDCYPVQET---Y---------- -----------------------------------TKNYS-----VTT-S TRFFDIHPGI---------------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Gallus_XP_418830.2 --------------------------------------MALATGGLLLLL GGLL-----------VRGGAGAE---PCR-APGQW------------EGR SVRYD----------------HGTG-RNTRAAVSYDGLNQRLR---ILEE RKALIPCKKFF-EYILLYKDA--VMFQIEQ-------------------- -------------------------------------------------- ---------------------------------------------VTKLC SK--IALT---EP--WDPYDIPTNSTFEDQYYIGG---PGDQIMVQEWSD R--KPARK-------LESWVGVYT--VKDCYPVQET---Y---------- -----------------------------------TKNYS-----VTT-S TRFFDLKLGIADP-SVFTPPS-TCQTAQP--------------RKMKDEC -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Lottia_tr_V4B6J2_XP_009065291.1 MANGGLDTMSLCEQKSALQDLTMSQPSFGIRLVNKYIPFVMKFIILLALL PIFT---------------GAVQ---KCC-TDKQF------------TAI LGEPN---------------QIVKG-NFQFTTLAEDFTSKLIA--TETYS FSPGNSSTKLV-RVVQDFNQK--KMFVIFD-------------------- -------------------------------------------------- ---------------------------------------------STSTC TA--KDLT---YD--MPSNCVPDDAEFIGQSYMGF---APNQVNISAFKW K--FAGTA----------DLLIMF--NDNCVPVVES--IS---------- -----------------------------------GVVGS---DPVDK-T YTFTNYNTGISDR-SVFNIPA-YCTQ------------------------ -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Lottia_tr_V4AF93_XP_009054031.1 ------------------------------------MKLLLLLTVLIPLC VSVP----------------TKP---GCC-VPPVW------------EGI QGMFS----------GDGSGPAPEL-IQQSALISYDEKRQMIN----INI TQSIHGLTSDV-RILTDYKKG--VQYLINS-------------------- -------------------------------------------------- ---------------------------------------------KSRSC TT--SKVP---QT--FQRFCIPDYFYYKGSFNVAF------TLRASTEQF -----------------------------IVPLIWS-------------- -----------------------------------KCKSN---------S SNFFKMRKACFSR-DIQLVVG-TCDCLFN--------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Lottia_tr_V4BE89_XP_009062103.1 ----------------------------------------MIAKVILLCL VASS---------------LAE----KCC-VPDTW------------EGI QQQSV----------GSIKNGIPTM-SEETITIHYDLTKNVAA----FDE SVTANGYTVKV-KVIMDFKAG--TEYII---------------------- -------------------------------------------------- ---------------------------------------------SGNHC SK--KVIS---HT--SRTRCVPDNAKFEGSHFGGS---GNNKVMFNSYSY Q--AANVT--------AHFSMT----NPGCVPVSQI--IY---------- -----------------------------------GSTNG---VQYFV-S QNFYDITPGVKDP-TVFNVPS-ICDNAMF-----------VKGPSSTHVG ILGQ---------------------------------------------- -------------------------------------------------- ------------------------------------- >Lingula_XP_013400786.1 -----------------------------------MKTVIAAFSVLIIVV PALS---------------QPPQ---PCC-TPPQW------------EGN VAQSQ----------GLNVAGQGHR-AAQIMKLSMDTNLKKVA----ASG QWYYDQQQGTF-QVLQDFKAG--VQYQIT--------------------- -------------------------------------------------- ---------------------------------------------NGGPC VK--SKLT---QP---WMGCMPKTSKFMGSAVVGL---GDDSIKVNNWAI F--MNSSS------VMGTSYTQVT--AKDCVPIGSS--LQ---------- -----------------------------------GSAKG---VGMMS-V QGVTNVSAGIKDP-SVFSLPA-SCQKAKE-----------ADEKDKDNGM DXGGGGGGEDARGLP----------------------------------- -------------------------------------------------- ------------------------------------- >Lingula_XP_013399691.1 ---------------------------------MKMKTAIAVFSVLIIVV PAMS---------------QPPQ---PCC-TPPQW------------EGN VAQSQ----------GQNVAGQGHR-AAQIMTLSMDANLKKVA----HRG QWYYDQQQGTF-QLLQDFKAG--VQYQIT--------------------- -------------------------------------------------- ---------------------------------------------NGGPC VK--SKLT---QP---WMGCIPKTSKFMGSAVLGL---GDDSIKVNNWAI F--MNSSS------LMGTSYTQVT--AKDCVPIGST--FQ---------- -----------------------------------GSAKG---VGMMS-V QGVTNVSAGIKDP-SVFSLPA-SCQKAKE-----------ADEKDKDSSM DIRLF--------------------------------------------- -------------------------------------------------- ------------------------------------- >Lingula_XP_013400763.1 ---------------------------------MKMKTAIAVFSVLIVVV PAMS---------------QPPQ---PCC-TPPQW------------EGN VAQSQ----------GQNVAGQGHR-AAQIMKLSMDANLKKVA----HRG QWYYDQQEGTF-QLLQDFKAG--VQYQIT--------------------- -------------------------------------------------- ---------------------------------------------NGGPC VK--SKLT---QP---WMGCIPKTSKFMGSAVLGL---GDDSIKVNNWAI F--MNSSS------LMGTSYTQVT--AKDCVPIGSS--FQ---------- -----------------------------------GSANG---VGMMS-V QGVTNVSAGIKDP-SVFSLPA-SCQKAKE-----------ADEKDKDSGM DIRLF--------------------------------------------- -------------------------------------------------- ------------------------------------- >Saccoglossus_XP_002732737.1 -------------------------------------MKLLVFLSFVACT VAF-----------------------KCC-PPKQF------------EGF IGSYG---------GSCSHQGQAGL-LFSWGQVHYDYKKAMVA----VEE TVYVDKQQEHV-QVIQDYANE--VMYLI---------------------- -------------------------------------------------- ---------------------------------------------IGGNC TK--SDLP---DT---EIMCVPDSAVYVMTQEYGM-----GAMTVDIYSY GSKLFGDA--------FFGQISVT--RDKCIPMGVN--LG---------- -----------------------------------INHPQ---ASIVM-S FGYANLTLGIKDP-SVFDIPE-ICHHNDV-----------IPFKVMGEKL SDRMKVVMSSYSAR------------------------------------ -------------------------------------------------- ------------------------------------- >Lingula_XP_013393824.1 -----------------------------------MLLVAVCLGILAVAA ADKK----------------------PCC-APPQW------------EGL LAEKM----------GTDHQGKAWL-LQEGALMSVSWPDKKIN--FM-GQ VNATGGTSVKF-RVIQDYKAK--QQYAI---------------------- -------------------------------------------------- ---------------------------------------------VHKNC TK--TALA---EE---MINGVPPNATYVGTFYLGA--GKDNELMFDTWLI K--YKGMD--------FQSELATT--VKDCIPMSWF--AF---------- -----------------------------------GTVNK---DKLIQ-S AGIVNVTLGIKDN-SVFTVPD-ICKKASN-----------EYPHPVLAGM ADQFRLRL------------------------------------------ -------------------------------------------------- ------------------------------------- >Lingula_XP_013408332.1 ----------------------------------MMIKLVLLLCTAVFGV LGAP------------GLTEAPT---PCC-TASQW------------EGV MLEVG----------GYAAQSHAGF-LKGSIAVSYDMLGKRVA---TVSH LNYSAGAQSNM-KVIQDFKGG--MQYVI---------------------- -------------------------------------------------- ---------------------------------------------MNTTC TK--SALK---GA--MPPNCMPDDAKFGGGFYFGS---PSSQLPCQRWLY T--YNGTT----------FDLTVT--QQDCIPVIET--EY---------- -----------------------------------SGTDA---------E TECRGKNIG-----SVFEE------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Lingula_XP_013399306.1 -----------------------------------MIKLVLLLCTAVFGV LGAP------------GLTEAPT---PCC-TASQW------------EGV MLEVG----------GYAAQSHAGF-LKGSIAVSYDMLGKRVA---TVSH LNYSAGAQSNM-KVIQDFKGG--MQYVI---------------------- -------------------------------------------------- ---------------------------------------------MNTTC TK--SALK---GA--MPPNCMPDDAKFGGGFYFGS---PSSQLPCQRWLY T--YNGTT----------FDLIVT--QQDCIPVIET--EY---------- -----------------------------------SGTDA---------E TECRGKNIG-----SVFEE------------------------------- -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Lingula_XP_013408344.1 -----------------------------------MTKLVLLLCVAVSCV LGTS----------NHPTATPPT---SCC-MPEQW------------EGQ MVEIG----------AYVSDGHAGT-FQGPITISYDKKGMRQV---TVSK LSYSAGLQANM-KIIQDFKGH--MQYVI---------------------- -------------------------------------------------- ---------------------------------------------NGNTC TK--SPLT---DA--MTPNCIPDGAKYWGGFYIGG---PDTQLPCNRWLY T--SKGTN----------VSLTVT--QQDCYPVLET--EY---------- -----------------------------------GNTPR---GGQMA-S IAFTSVRPGIQDP-TVFDPPS-ICNKVSK-----------EHPHHQLQGL HRRAMNILRR---------------------------------------- -------------------------------------------------- ------------------------------------- >Lingula_XP_013411471.1 -----------------------------------MTKLVLLLCVAVSCV LGTP----------NHPRATPPK---PCC-MLDQW------------DGM MAEVG--------------------------TYVYDTHAGTYR------- --------------------G--FQYVIFT-------------------- -------------------------------------------------- ---------------------------------------------EGNTC TK--SPLT---GT--MPPNCIPDDAKFGGAFYMGG---PDYRLPCHRWLY T--SNGRN----------VSLTVT--QQDCYPVLET--EY---------- -----------------------------------SAMPK---GGQMA-S SAFAYVHSGIHDP-TVFNIPS-FCNKVSK-----------EHPHHQLQGP HLHALNRLRI---------------------------------------- -------------------------------------------------- ------------------------------------- >Crassotreas_XP_011420637.1 --------------------------------------MVLRFVFTVVCL IGGL------------HDVISRQ---GCC-GPKQW------------TGV AIQKL--------GRYDHDLDVASL-ADISTNVAYDYVAKKIS--LQQKI HNITTDNTDLV-HVIYDFKQK--TEYTIT--------------------- -------------------------------------------------- ---------------------------------------------NGKVC IA--TPIS---GE--MWPNCVPENASHLGTYNISG-------PVVDVYRV V--TPGGA---------TVRLSVT--YELCYPGTESLLTS---------- -----------------------------------GPVYD------LT-V SVYENVTKGITDP-SVFNVPV-FCHHRQM-----------KTNYTSSTIT ELIHRSLLSWR--------------------------------------- -------------------------------------------------- ------------------------------------- >Haliotis_ABO26643.1 ------------------------------------MLSVVLFALIAAAV AD------------------------PCC-TPDQW------------EGS FGSIT----------GTVTDDMTKT-IKVNGMMAYDFINKMVA----QTT VVTEGSMKMQN-KTIINYNTK--MMYLIDM-------------------- -------------------------------------------------- ---------------------------------------------TRDLC EV--KSVD---QP--MMQACTPQGATETGTFYFGA--GEDNMLDATSYKF T--VNTMG----------SYLTVT--SLDCVPITSV--TY---------- -----------------------------------GQAGN---TAIMT-S VGFVDIMLKIQDP-SVFDPPA-ACDEAKV-----------TPGENYALHS FFGTPTHHHL---------------------------------------- -------------------------------------------------- ------------------------------------- >Lottia_XP_009058449.1 -------------------------------------MKLLVLVYLIAVV YSQS----------------TVP---GCC-VPPQW------------EGL QGTII----------GRVDGSGRQQVISENVETFYDQTNNRMA----LNV ATDFTGKMQYL-RIIQLYSKK--IQYVIDL-------------------- -------------------------------------------------- ---------------------------------------------DTQTC KS--NTLS---GT--FPPICLPKDAMPEGPYYFGI---GDTKLESISFRF N--VSGAN----------VTVSAL--REGCIPILEN--IV---------- -----------------------------------TSGQG---IAQMQ-T TGFVNLSPGISQP-SMFDVPD-ICNQAKD----------LGLEASRIYQR KWFPFS-------------------------------------------- -------------------------------------------------- ------------------------------------- >Lottia_tr_V4A6Z5_XP_009058447.1 --------------------------------------MILIIGALVAVA VADP----------------SEP---GCC-LPPQW------------EGF QGAII----------GQVIGALPKS-FHEATKISYDETNNKIA---YTVV ETAGASSSPAI-KIIQDYSEG--QQYIINM-------------------- -------------------------------------------------- ---------------------------------------------AAQTC QP--SALP---KT--FQKICLPADAKPLGKFYFGI---GDTKLEAVSFGV Y--VNGAN----------VTAVLT--SDNCVPIFEV--LT---------- -----------------------------------TANTK---MAMMQ-A LAFINITPGILNP-DVFSIPD-ICKQRKP-----------VSFGEAVRRT GLFSGH-------------------------------------------- -------------------------------------------------- ------------------------------------- >Lottia_tr_V3Z252_XP_009064639.1 ----------------------------------MMKYCLVVAVVVVGVV IGEP----------------SKP---GCC-TPSQW------------EGQ QGSTI----------GIVDGGIPSV-RTSMVRISYDEKNQRIA----YVT SESTPQGEKNY-KIIYDYSRK--FQFIVDL-------------------- -------------------------------------------------- ---------------------------------------------DTKHC TV--SSLT---DP--FMKLCLPVDAQPKGKFYYGI---DGNNLPAMAFSL N--VNGTM----------ITVVTT--ADNCIPIAEV-------------- -----------------------------------LVDGQAQGVSQMH-A SGFVNLTSGIKDP-SVFIPPG-TCTQ------------------------ -------------------------------------------------- -------------------------------------------------- ------------------------------------- >Branchiostoma_XP_002599956.1 ---------------------------------------MQGSYSTIADT VDAP---------------TPG----PCC-TPTQW------------SGT LRLIS----------SSVSGGRLST-TNQTMQYYYDYENMKVA------- -----TVGEGF-RIVDDFNKM--VKYSI---------------------- -------------------------------------------------- ---------------------------------------------FYGTC TT--SSLL---KP---LLNCVPANVSFVGSFQYGG----PQGFQVNEYFD G--AFGPN--------TTRRNAYT--TDSCIPVREI--LV---------- -----------------------------------STGQA----PVVV-S EEFVDIVPSIEDP-SVFDIPSPPCPNVTDVDSAAESSTTETTTGQGTFED QTGTYSTTTDPLDDSTPGPCCAPKQWSGTMRITSSSVIDGKLTKAAFVGS YQYGGPQGFYVNEYFDDTFGPNTTRRNSYTADGCIAVLETLVATGPAPLV VTIEFVDIVPSIEDPSVFDITSPPCPTVSSDRQRQCD >Lottia_tr_V4BP88_XP_009058446.1 ---------------------------------------MLKLVVISACL VAVLGQYKFNDESELQMEYPTVA---GCC-TPDQW------------EGY QGIIG----------GYARFIKKGA-VYGYTKVSYDAKNERIA----AVA NMTRDGKNHAI-RVIEDYQNG--KIYIISL-------------------- -------------------------------------------------- ---------------------------------------------KKNWC KT--LTTK---RS--FKKACVPKSAVKIGEFYQGT---GLRKLTQVAYYY EHKSFFNV--------VRSTFDLT--KKGCIPTNEV--IS---------- -----------------------------------GRVKG---VNFMD-V VGFSDITAGIKDP-AVFNPPE-SCNKTES---------DSGPNFELHEHM LYREFRYFGL---------------------------------------- -------------------------------------------------- ------------------------------------- >Branchiostoma_XP_019625610.1 ------------------------------------MYAVVLAVIALALV GSVS---------------AQPQ---PCC-TPNQW------------EAT MVEAQ----------GYVQNMQPKT-LVGTIEVSYDFDNKKMA----FNQ RLNNSGTPILV-KVIINYNEG--KMYSI---------------------- -------------------------------------------------- ---------------------------------------------SDGVC TE--LSAP---TP-DMPQQCISAGAMFERTMRLGG----PGGLEVNSFGL W--NVQGV--------AYGTAQMT--SRDCLPVTEV--LI---------- -----------------------------------AEQTG-QVLGSVQ-A IIFDGVTTGIKDP-SVFDPPSPPCNSIPD-----------AHHQESRSGG TPFFQRTLGRFGIPVF---------------------------------- -------------------------------------------------- ------------------------------------- >Branchiostoma_XP_019647129.1 ----------------------------------MRQVVVLVLCAVLGLC AGQK----------------------PCC-TPDQW------------EGT IQGLQ----------GFLVDDKLGT-VDGTVQISYDFTNQKLA---LVEN LNETGTGNIMV-KVIQDYKKG--KQYVI---------------------- -------------------------------------------------- ---------------------------------------------RGKSC ME--SVLK---G---FVKQCIPDNATNIGSFSFGG--MAPGGLECDAFMT T--FAGMD-------NNYIISDVT--REGCYPVTQVTVNL---------- -----------------------------------MRQHS-----TVT-T QIFTDITTGIKDP-SVFSPPEPPCAKNHQ-----------VVFEDTSSSF QTGRLGAPPV---------------------------------------- -------------------------------------------------- ------------------------------------- >Branchiostoma_XP_002609505.1 -----------------------------------MLKFVAVALLMTVCV FSVW-----------------GE---QCC-APKQW------------ESF VGIEN----------TTAVDGMIKV-TQQYAIESYDFDKKKIA------- ---MVFPAINM-RLIQDYNKG--MMYTI---------------------- -------------------------------------------------- ---------------------------------------------VAGMC FT--TPWP---FP---MVNCIPDNATMLASFEMGG----KDGLMIEQYQL QDFLPGFN----------GYIQFT--RPGCLPVSQT--QY---------- -----------------------------------YESYA-------T-M FGFTNITEGIKDP-SVFDIPSPPCPMDVD-----------NVVKPLLFEP AHP----------------------------------------------- -------------------------------------------------- ------------------------------------- >Branchiostoma_XP_019625480.1 ------------------------------------MKIVAIAFLLGVCA VVVE----------------------GCC-LPKQF------------ECV VGVQN----------ATFRAGKLDV-SSTGFMHSVDFINKKVA--YV--- -------GQDF-KMVQDYNKM--MQYVVSQ-------------------- -------------------------------------------------- -----------------------------------------------GYC IP--SKLT---MP---IDNCMPVNATVATRLDMGG----PKGVTLDVYDV ETISPGPG-------LGQYKGSYTFNRDGCIPFSQI--LM---------- -----------------------------------TEGSV-------A-T LGYVNMTFGIKDP-SVFDVPSPPCPKDTD---------GFENSLEEQTAS SWPLFPSLP----------------------------------------- -------------------------------------------------- ------------------------------------- >Branchiostoma_XP_002613625.1 ----------------------------------------MTAFLLGGCS VMVE----------------------ACC-LPKQF------------ECT AGLQN----------ATFRGGKLDV-SSTVFMHSVDLVNKKVS--YV--- -------GQSF-KIVQDYNKM--MQYTISQWYCRVSKLTTPIHDCMPANA TIATSMAMGGPKGIMMDVYDIEKISPGARLPFKGTLSLNQEGCVPFSEIL KTEGSIATLAYVNMTYGIKDPSVFDVPSPPCPKDTDNFVMMQYTISNGYC TV--NKLM---KP---IDNCISANATVATTVDMGG----PKGVTLDVYNV EKISPGPG------IFFKGSIAFN--QEGCIPFSEI-------------- -----------------------------------LMTEG-----SYA-T VSYINMTFGIKDP-SVFDVPSPPCPKDTD---------NFVTSLQQQPAP SWPILPSLP----------------------------------------- -------------------------------------------------- -------------------------------------