{"text_format":"2","workbook":"xlsx","n_sheets":3,"sheets":["README","BLM","RAD51"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"README","index":0,"n_rows":6,"n_cols":1,"rows_kept":6,"cut":false,"hidden":false,"merged":[]}
["Table S3: Top 50 genes co-evolved with BLM and RAD51 in different clades. "]
["Genes that are associated with cell cycle or DNA repair are highlighted. "]
["On the right, the overlap between the cell cycle and DNA repair genes co-evolved with BLM or RAD51 in different clades. "]
["The lower triangle indicates the number of cell cycle and DNA repair genes co-evolved with RAD51 in both clades. "]
["The diagonal indicates the number of cell cycle and DNA repair genes among the top 50 genes co-evolved with RAD51 in each clade. "]
["The upper triangle indicates the p-value for the size of the overlap (hypergeometric test with Bonferroni correction)."]

{"sheet":"BLM","index":1,"n_rows":51,"n_cols":16,"rows_kept":51,"cut":false,"hidden":false,"merged":[]}
["Mammalians","Vertebrates","Animals","Fungi","Plants","Protists","Eukaryotes",null,null,"Mammalians","Vertebrates","Animals","Fungi","Plants","Protists","Eukaryotes"]
["PNPLA8","PNPLA8","DAP3","RECQL","TAF5L","RECQL","RECQL",null,"Mammalians",18,2.394E-027,0.02835,1,1,1,1]
["SUCO","SUCO","VRK1","RECQL5","ADRM1","RECQL5","RECQL5",null,"Vertebrates",13,20,5.544E-006,1,1,1,1]
["XRCC4","AGGF1","DPM1","WRN","UBE3C","WRN","WRN",null,"Animals",2,4,12,1,1,1,1]
["UBE3A","TOPBP1","ISY1-RAB43","RECQL4","TACC3","RECQL4","HELLS",null,"Fungi",0,0,0,16,1,2.0118E-005,4.389E-007]
["LRRK2","SSB","ELP2","ATP11C","EME1","NEDD4","ATP11B",null,"Plants",0,0,0,0,14,1,1]
["PPP1R12A","ATAD2","ISY1","ATP11A","PPME1","AREL1","SMARCA1",null,"Protists",0,0,0,4,0,20,1.8165E-008]
["DAP3","CEP76","ASCC3","CDC20","WWC1","NEDD4L","CHD1L",null,"Eukaryotes",0,0,0,5,0,6,23]
["ATAD2","SPDYE1","PSMD12","XPNPEP2","HIPK4","SMURF2","ATP11C"]
["SPDYE4","SPDYE4","GPR152","KIF12","WARS2","HECW2","SMARCA5"]
["TOPBP1","SPDYE16","NEUROG2","KIF24","SRA1","SMURF1","SKIV2L2"]
["CEP350","FANCL","MYLK3","RARS2","ABCD3","HECW1","SMARCAD1"]
["AGGF1","SPDYE2B","PUS3","ATP11B","ERCC2","HACE1","ATP8B4"]
["SPDYE1","SPDYE2","SPDYE2","TARS2","WDR24","CHD8","ATP11A"]
["BCO2","SPDYE6","SPDYE2B","ARL11","TAF5","SKIV2L2","KIFC2"]
["MAATS1","SPDYE5","SPDYE6","TARS","DIEXF","ERCC6","ATP8A1"]
["FANCL","AP5M1","NAA50","KIF2C","ABCD1","CHD9","DARS"]
["VRK1","VRK1","ZNF793","TARSL2","VPS13B","DIS3","PPP2CA"]
["SSB","CCDC174","SPAST","XPNPEP1","ABCD2","CHD6","PPP2CB"]
["NUP205","CSPP1","MRPS33","CDC20B","ABCD4","DIS3L","ATP8B3"]
["SPDYE16","UBE3A","RHNO1","BRIP1","UBE3B","CHD4","RAD54B"]
["TBC1D23","PPP1R12A","SPDYE5","KIF2B","SLC9A8","CHD7","UBA6"]
["SYCP1","DPM1","PNPLA8","RTEL1","PIK3R2","SMARCA1","PSMD14"]
["RNF182","NUP205","DCXR","KIFC2","WDR82","HELLS","ATP8A2"]
["WDPCP","XRCC4","PAPD4","ATP10B","PAK3","CHD3","ATP8B2"]
["PSMD12","ELP2","SSB","RARS","VARS","CHD2","WARS"]
["SPDYE5","NGF","MRPS6","CARS2","FAHD2A","SMARCA5","TARSL2"]
["SASS6","PLCZ1","SPDYE1","KIF2A","DDX47","WWP2","SAR1B"]
["CSPP1","DAP3","TBC1D23","ATP9A","EPS15L1","WWP1","DRG1"]
["SPDYE6","RBM22","RBM22","KIF9","FAHD2B","ERCC6L","SAR1A"]
["SPDYE2B","SASS6","SIAH3","KIF6","SLC9A5","ATP13A1","TARS2"]
["SPDYE2","RNF182","EIF3E","KIF15","ANGEL1","CHD5","ACTL9"]
["TBC1D31","SPDYE3","SEC24D","ARL10","POLR2C","ITCH","UBA7"]
["CEP76","ULK4","RPS3","KIFC3","BRF1","CHD1","PMM2"]
["ANKS4B","RPS3","CD46","HERC6","VARS2","HUWE1","PSMB5"]
["GNL2","ANKS4B","RIOK2","ATP10D","MTRF1L","ATP10D","KIFC1"]
["MPHOSPH8","LRRK2","KIF11","ATP10A","PAK1","ATP6V0D2","IARS"]
["PLCZ1","LHCGR","BMPR1A","HFM1","HIPK3","EIF5B","ATP8B1"]
["SLU7","PSMD12","TAZ","HERC3","TTC27","DRG2","KIF18B"]
["CCDC174","MTRF1","CHIC1","EEF2","ECT2","POLA1","DIMT1"]
["AP5M1","GPR152","NBPF15","ARL4D","FAHD1","ATP10A","PSMB8"]
["KRIT1","SKA2","HEATR5A","KIF27","SLC9A2","ATP6V0A2","TARS"]
["TRIP12","ZWILCH","GDF15","ATP8B4","GPD2","ATP6V0A4","PSMA5"]
["YTHDC1","BCO2","SLCO1B1","KIF18B","RARS2","ATP11B","ARL14"]
["NUCKS1","SCG2","C5orf47","SEC11C","PAK2","RAD54B","RARS2"]
["USP16","RHNO1","IFT172","HERC4","MAP4K2","AGAP9","PPP1CB"]
["C11orf54","CCAR1","NBPF1","ATP8A2","ABHD1","ATP10B","PPP6C"]
["PURG","SUV420H1","KIFC2","KIF4A","POLE","ATP11A","PPP1CC"]
["C7orf62","KRIT1","NBPF12","HERC5","RSL24D1","ATP11C","DRG2"]
["DPM1","ICE2","LLPH","CDC42BPA","RQCD1","ATP8A1","PPP1CA"]
["SKA3","YTHDC1","SPDYE16","ATP8B2","CPSF2","ATP8B4","ARL10"]

{"sheet":"RAD51","index":2,"n_rows":51,"n_cols":16,"rows_kept":51,"cut":false,"hidden":false,"merged":[]}
["Mammalians","Vertebrates","Animals","Fungi","Plants","Protists","Eukaryotes",null,null,"Mammalians","Vertebrates","Animals","Fungi","Plants","Protists","Eukaryotes"]
["DPP8","DIP2B","DMC1","DMC1","DMC1","DMC1","DMC1",null,"Mammalians",13,1.0227E-010,1,1,1,1,1]
["DIP2B","PSMD14","YES1","RAD51B","XRCC3","RAD51B","RAD51B",null,"Vertebrates",6,17,1,1,1,1,1]
["CDC27","DIP2A","FGR","RAD51C","BYSL","XRCC3","XRCC3",null,"Animals",0,1,27,1,1,1,1]
["NOL10","NPEPPS","FYN","XRCC3","RAD51B","XRCC2","XRN2",null,"Fungi",0,0,1,16,2.0979E-006,2.667E-008,6.636E-011]
["STK38","SNRNP40","SLC25A5","XRN2","RAD51C","CENPA","RAD51C",null,"Plants",0,0,1,4,12,1.1571E-006,8.274E-007]
["PSMD14","NOL10","SRC","XRN1","POTEM","ZDHHC24","ABCE1",null,"Protists",0,0,1,5,4,14,2.499E-011]
["MEP1B","SAR1B","SLC25A6","DDI1","POTEG","ZDHHC15","XRN1",null,"Eukaryotes",0,0,1,6,4,6,13]
["DIP2A","PDK3","SLC25A31","XRCC2","ASB8","RAD51C","PPP5C"]
["CDC73","STK38","MYH14","DDI2","ZDHHC13","ZDHHC22","STIP1"]
["NPEPPS","UBE2E3","BTBD10","ZCCHC13","ASB7","ZDHHC20","UBA52"]
["BTBD10","BTBD10","AKT3","TTC3","POTEH","ZDHHC12","DDI1"]
["LEF1","RALA","SLC25A4","CNBP","FEM1B","ZDHHC2","TUBA4B"]
["MTRF1","SAR1A","BLK","TERT","PSMD10","EIF4A1","FTSJ1"]
["GABRA1","SHOC2","TXK","STIP1","CDKN2C","RAD51D","H3F3C"]
["ADAM23","SLC39A9","SRP54","UPF1","ANKRD53","EIF4A2","ARL4A"]
["DNAJC12","TAOK3","FRK","MYO18A","ZDHHC17","EIF4A3","HIST2H3PS2"]
["TAOK3","CLIC4","GRAPL","PPP5C","STIP1","SBK2","HIST2H3C"]
["PEX7","CAB39","HCK","MYO18B","GMEB1","ZMYM3","ZCCHC13"]
["P4HA1","PPP6C","GRB2","ABCE1","NEIL2","RAB30","HIST1H3B"]
["TAF2","ROCK1","LYN","MYH14","XAF1","RAB43","HIST3H3"]
["UBE2E3","RBBP4","AKT1","MYH9","NRIP3","ZDHHC23","TUBA3C"]
["SRP54","YES1","GRAP","MYH10","POTEC","CCT5","TUBA3E"]
["GOSR1","ROCK2","AKT2","MYH11","POTEB2","RAB19","TUBA8"]
["CHUK","TEAD1","UCK2","MYH1","ESPNL","ZDHHC21","TUBA4A"]
["SLC39A9","KCTD6","GFPT1","FOXJ1","ANKRD30BL","TRIM65","TUBAL3"]
["PPP6C","SEC23A","MAPK8","MYH7","ANKRD63","H3F3C","ARL17A"]
["ING3","RGS6","CSK","HELZ2","TRAFD1","RAB33B","TUBA1A"]
["TBX20","MED10","MAPK10","MYH13","NRIP2","TPT1","RAB3C"]
["SNRNP40","SRP54","DDX1","SLF1","ANKRD24","HIST2H3C","RAB3D"]
["FZD3","PRKAG1","NDUFV2","NRIP2","ANKRD2","EEF2","TUBA1B"]
["TMEFF1","GABRA1","XRN2","MYH6","ENSP00000478796.1","PDIK1L","TUBA1C"]
["KCTD6","PPA1","GFPT2","MYH2","TTC3","RAB27B","RAB3A"]
["TMOD2","SEC61A1","UBE2B","FTSJ1","ANKRA2","HIST1H3B","ARL5A"]
["GPBP1L1","TBX20","UBE2E3","MYH7B","POTEB3","RAB36","DRG1"]
["KRIT1","PPP2CB","UBE2A","MUS81","FEM1C","RNF4","FTSJ2"]
["DRD3","NAA15","VPS4B","MYH8","ANKRD62","HIST2H3PS2","ARL4D"]
["SPAG9","KLHL13","HSPA1A","MYH4","MRTO4","RPL37A","ARL5B"]
["DHX15","DHX15","HSPA1B","MYH3","ENSP00000479139.1","HIST3H3","ARL4C"]
["GOLPH3L","PPP2CA","HSPA1L","XPR1","ASB3","RAB34","RAB3B"]
["SLC25A14","HSPE1-MOB4","RAB2A","FOXK1","DHX8","WDR97","RAB2B"]
["ST7L","UBE2E1","HPCAL4","MYH15","ANKRD20A3","RAB39B","RAB30"]
["FLVCR1","FBXL20","ITCH","NRIP3","ASB12","TRIM60","CENPA"]
["SHOC2","RPS12","PPP1CB","FOXK2","GPR75-ASB3","UBE2L6","ARL1"]
["PRMT3","KLHL9","PRPS1L1","UBA52","TMF1","RAB33A","RAB2A"]
["MSANTD3-TMEFF1","PIK3R3","PRPS1","FOXD4L4","POTED","ZDHHC19","RAB10"]
["PPA1","GALNT1","PRPS2","FOXD4L5","ANKRD20A1","UBE2U","ENSP00000438507.1"]
["ROCK2","NDST4","HSPA2","FOXD4L6","ANKRD20A4","SBK3","RAB22A"]
["MREG","DIP2C","HSPA8","FOXL2","ASB18","TRIM7","RAB31"]
["UBXN4","CTNNB1","SNX12","FOXD4L3","ANKRD20A2","PIM3","ARL5C"]
["ROCK1","PRKD3","VSNL1","GPD1L","NFKBIA","UBL7","RAB39B"]