{"text_format":"2","workbook":"xlsx","n_sheets":10,"sheets":["Fig. 3d","Fig. 4a","Fig. 4b","Fig. 4e","Fig. 5a","Fig. 6a","Fig. 6b","Fig. 6c","Fig. 6d","Fig. S8"],"not_rendered":{"charts":0,"images":0,"macros":0,"external_links":0,"defined_names":0,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"run_cost":"one","rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"Fig. 3d","index":0,"n_rows":34,"n_cols":9,"rows_kept":34,"cut":false,"hidden":false,"merged":[]}
["Two-way ANOVA","Ordinary","Log-transformed data"]
["Alpha",0.05]
[]
["Source of Variation","% of total variation","P value","P value summary","Significant?"]
["Interaction",0.1016,0.42880000000000001,"ns","No"]
["Time",85.87,"< 0,0001","****","Yes"]
["shRNA",8.3979999999999997,"< 0,0001","****","Yes"]
[]
["ANOVA table","SS","DF","MS","F (DFn, DFd)","P value"]
["Interaction",4.718E-3,1,4.718E-3,"F (1, 19) = 0,6536","P = 0,4288"]
["Time",3.9870000000000001,1,3.9870000000000001,"F (1, 19) = 552,4","P < 0,0001"]
["shRNA",0.39,1,0.39,"F (1, 19) = 54,02","P < 0,0001"]
["Residual",0.1371,19,7.2179999999999996E-3]
[]
["Number of missing values",1]
[]
["Compare each cell mean with the other cell mean in that row."]
[]
["Number of families",1]
["Number of comparisons per family",2]
["Alpha",0.05]
[]
["Uncorrected Fisher's LSD","Mean Diff,","95% CI of diff,","Significant?","Summary","Individual P Value"]
[]
["shCTL - shFmr1"]
["15 min",-0.28999999999999998,"-0,3926 to -0,1873","Yes","****","< 0,0001"]
["30 min",-0.23250000000000001,"-0,3402 to -0,1248","Yes","***",2.0000000000000001E-4]
[]
[]
["Test details","Mean 1","Mean 2","Mean Diff,","SE of diff,","N1","N2","t","DF"]
[]
["shCTL - shFmr1"]
["15 min",-7.2830000000000004E-3,0.28270000000000001,-0.28999999999999998,4.9050000000000003E-2,6,6,5.9109999999999996,19]
["30 min",0.85680000000000001,1.089,-0.23250000000000001,5.1450000000000003E-2,5,6,4.5190000000000001,19]

{"sheet":"Fig. 4a","index":1,"n_rows":48,"n_cols":9,"rows_kept":48,"cut":false,"hidden":false,"merged":[]}
["Two-way RM ANOVA","Matching: Stacked"]
["Alpha",0.05]
[]
["Source of Variation","% of total variation","P value","P value summary","Significant?"]
["Interaction",3.1680000000000001,"< 0,0001","****","Yes"]
["Time",75.63,"< 0,0001","****","Yes"]
["Genotype",5.391,3.3999999999999998E-3,"**","Yes"]
["Subjects (matching)",7.3040000000000003,"< 0,0001","****","Yes"]
[]
["ANOVA table","SS","DF","MS","F (DFn, DFd)","P value"]
["Interaction",70904,7,10129,"F (7, 112) = 5,958","P < 0,0001"]
["Time",1692000,7,241775,"F (7, 112) = 142,2","P < 0,0001"]
["Genotype",120640,1,120640,"F (1, 16) = 11,81","P = 0,0034"]
["Subjects (matching)",163457,16,10216,"F (16, 112) = 6,010","P < 0,0001"]
["Residual",190396,112,1700]
[]
["Number of missing values",0]
[]
["Compare each cell mean with the other cell mean in that row."]
[]
["Number of families",1]
["Number of comparisons per family",8]
["Alpha",0.05]
[]
["Sidak's multiple comparisons test","Mean Diff,","95% CI of diff,","Significant?","Summary"]
[]
["KO - WT"]
[0,-9.8889999999999993,"-78,61 to 58,83","No","ns"]
[15,-43.44,"-112,2 to 25,28","No","ns"]
[30,-79.33,"-148,1 to -10,61","Yes","*"]
[45,-132.6,"-201,3 to -63,83","Yes","****"]
[60,-116.8,"-185,5 to -48,06","Yes","****"]
[90,-50.67,"-119,4 to 18,06","No","ns"]
[120,-20.11,"-88,83 to 48,61","No","ns"]
[180,-10.33,"-79,06 to 58,39","No","ns"]
[]
[]
["Test details","Mean 1","Mean 2","Mean Diff,","SE of diff,","N1","N2","t","DF"]
[]
["KO - WT"]
[0,109.9,119.8,-9.8889999999999993,24.79,9,9,0.39900000000000002,128]
[15,351.1,394.6,-43.44,24.79,9,9,1.7529999999999999,128]
[30,379.6,458.9,-79.33,24.79,9,9,3.2010000000000001,128]
[45,271.39999999999998,404,-132.6,24.79,9,9,5.3479999999999999,128]
[60,227.2,344,-116.8,24.79,9,9,4.7119999999999997,128]
[90,180.6,231.2,-50.67,24.79,9,9,2.044,128]
[120,150.9,171,-20.11,24.79,9,9,0.81140000000000001,128]
[180,129.4,139.80000000000001,-10.33,24.79,9,9,0.41689999999999999,128]

{"sheet":"Fig. 4b","index":2,"n_rows":52,"n_cols":9,"rows_kept":52,"cut":false,"hidden":false,"merged":[]}
["Two-way RM ANOVA","Matching: Stacked"]
["Alpha",0.05]
[]
["Source of Variation","% of total variation","P value","P value summary","Significant?"]
["Interaction",2.266,1.34E-2,"*","Yes"]
["Time",70.27,"< 0,0001","****","Yes"]
["Genotype",5.4290000000000003,1.17E-2,"*","Yes"]
["Subjects (matching)",9.0559999999999992,"< 0,0001","****","Yes"]
[]
["ANOVA table","SS","DF","MS","F (DFn, DFd)","P value"]
["Interaction",4043,9,449.3,"F (9, 126) = 2,445","P = 0,0134"]
["Time",125400,9,13933,"F (9, 126) = 75,82","P < 0,0001"]
["Genotype",9688,1,9688,"F (1, 14) = 8,393","P = 0,0117"]
["Subjects (matching)",16159,14,1154,"F (14, 126) = 6,281","P < 0,0001"]
["Residual",23155,126,183.8]
[]
["Number of missing values",0]
[]
["Compare each cell mean with the other cell mean in that row."]
[]
["Number of families",1]
["Number of comparisons per family",10]
["Alpha",0.05]
[]
["Sidak's multiple comparisons test","Mean Diff,","95% CI of diff,","Significant?","Summary"]
[]
["KO - WT"]
[0,-1.25,"-25,08 to 22,58","No","ns"]
[15,-13.63,"-37,46 to 10,21","No","ns"]
[30,-2.375,"-26,21 to 21,46","No","ns"]
[45,-10.25,"-34,08 to 13,58","No","ns"]
[60,-17.13,"-40,96 to 6,708","No","ns"]
[75,-22.5,"-46,33 to 1,333","No","ns"]
[90,-29.38,"-53,21 to -5,542","Yes","**"]
[120,-30.88,"-54,71 to -7,042","Yes","**"]
[150,-21.88,"-45,71 to 1,958","No","ns"]
[180,-6.375,"-30,21 to 17,46","No","ns"]
[]
[]
["Test details","Mean 1","Mean 2","Mean Diff,","SE of diff,","N1","N2","t","DF"]
[]
["KO - WT"]
[0,179.4,180.6,-1.25,8.3789999999999996,8,8,0.1492,140]
[15,146.30000000000001,159.9,-13.63,8.3789999999999996,8,8,1.6259999999999999,140]
[30,113.3,115.6,-2.375,8.3789999999999996,8,8,0.28349999999999997,140]
[45,92.88,103.1,-10.25,8.3789999999999996,8,8,1.2230000000000001,140]
[60,86.75,103.9,-17.13,8.3789999999999996,8,8,2.044,140]
[75,81.88,104.4,-22.5,8.3789999999999996,8,8,2.6850000000000001,140]
[90,87,116.4,-29.38,8.3789999999999996,8,8,3.5059999999999998,140]
[120,99.88,130.80000000000001,-30.88,8.3789999999999996,8,8,3.6850000000000001,140]
[150,127.1,149,-21.88,8.3789999999999996,8,8,2.6110000000000002,140]
[180,144.1,150.5,-6.375,8.3789999999999996,8,8,0.76080000000000003,140]

{"sheet":"Fig. 4e","index":3,"n_rows":71,"n_cols":9,"rows_kept":71,"cut":false,"hidden":false,"merged":[]}
["InsR"]
[]
["Two-way ANOVA","Ordinary"]
["Alpha",0.05]
[]
["Source of Variation","% of total variation","P value","P value summary","Significant?"]
["Interaction",0.12690000000000001,0.78239999999999998,"ns","No"]
["Treatment",50.78,"< 0,0001","****","Yes"]
["Genotype",19.559999999999999,2.7000000000000001E-3,"**","Yes"]
[]
["ANOVA table","SS","DF","MS","F (DFn, DFd)","P value"]
["Interaction",84.49,1,84.49,"F (1, 18) = 0,07857","P = 0,7824"]
["Treatment",33799,1,33799,"F (1, 18) = 31,43","P < 0,0001"]
["Genotype",13016,1,13016,"F (1, 18) = 12,10","P = 0,0027"]
["Residual",19356,18,1075]
[]
["Number of missing values",2]
[]
["Compare each cell mean with the other cell mean in that row."]
[]
["Number of families",1]
["Number of comparisons per family",2]
["Alpha",0.05]
[]
["Uncorrected Fisher's LSD","Mean Diff,","95% CI of diff,","Significant?","Summary","Individual P Value"]
[]
["WT - KO"]
["Saline",-52.78,"-92,56 to -13,01","Yes","*",1.21E-2]
["Insulin",-44.91,"-88,49 to -1,341","Yes","*",4.3999999999999997E-2]
[]
[]
["Test details","Mean 1","Mean 2","Mean Diff,","SE of diff,","N1","N2","t","DF"]
[]
["WT - KO"]
["Saline",100,152.80000000000001,-52.78,18.93,6,6,2.7879999999999998,18]
["Insulin",182.7,227.6,-44.91,20.74,5,5,2.1659999999999999,18]
[]
["Akt"]
[]
["Two-way ANOVA","Ordinary"]
["Alpha",0.05]
[]
["Source of Variation","% of total variation","P value","P value summary","Significant?"]
["Interaction",5.7619999999999996,9.2399999999999996E-2,"ns","No"]
["Treatment",53.78,"< 0,0001","****","Yes"]
["Genotype",11.68,2.1499999999999998E-2,"*","Yes"]
[]
["ANOVA table","SS","DF","MS","F (DFn, DFd)","P value"]
["Interaction",10525,1,10525,"F (1, 16) = 3,204","P = 0,0924"]
["Treatment",98238,1,98238,"F (1, 16) = 29,90","P < 0,0001"]
["Genotype",21329,1,21329,"F (1, 16) = 6,492","P = 0,0215"]
["Residual",52565,16,3285]
[]
["Number of missing values",0]
[]
["Number of families",1]
["Number of comparisons per family",2]
["Alpha",0.05]
[]
["Uncorrected Fisher's LSD","Mean Diff,","95% CI of diff,","Significant?","Summary","Individual P Value"]
[]
["WT - KO"]
["Saline",-19.43,"-96,28 to 57,42","No","ns",0.59930000000000005]
["Insulin",-111.2,"-188,0 to -34,34","Yes","**",7.4000000000000003E-3]
[]
[]
["Test details","Mean 1","Mean 2","Mean Diff,","SE of diff,","N1","N2","t","DF"]
[]
["WT - KO"]
["Saline",100,119.4,-19.43,36.25,5,5,0.53610000000000002,16]
["Insulin",194.3,305.5,-111.2,36.25,5,5,3.0670000000000002,16]

{"sheet":"Fig. 5a","index":4,"n_rows":35,"n_cols":9,"rows_kept":35,"cut":false,"hidden":false,"merged":[]}
["Two-way RM ANOVA","Matching: Stacked"]
["Alpha",0.05]
[]
["Source of Variation","% of total variation","P value","P value summary","Significant?"]
["Interaction",6.0979999999999999,4.0000000000000002E-4,"***","Yes"]
["AT type",49.15,"< 0,0001","****","Yes"]
["Genotype",19.07,"< 0,0001","****","Yes"]
["Subjects (matching)",16.190000000000001,8.9700000000000002E-2,"ns","No"]
[]
["ANOVA table","SS","DF","MS","F (DFn, DFd)","P value"]
["Interaction",160500,1,160500,"F (1, 26) = 16,71","P = 0,0004"]
["AT type",1294000,1,1294000,"F (1, 26) = 134,7","P < 0,0001"]
["Genotype",501986,1,501986,"F (1, 26) = 30,62","P < 0,0001"]
["Subjects (matching)",426211,26,16393,"F (26, 26) = 1,707","P = 0,0897"]
["Residual",249688,26,9603]
[]
["Number of missing values",0]
[]
["Compare each cell mean with the other cell mean in that row."]
[]
["Number of families",1]
["Number of comparisons per family",2]
["Alpha",0.05]
[]
["Sidak's multiple comparisons test","Mean Diff,","95% CI of diff,","Significant?","Summary","Individual P Value"]
[]
["WT - KO"]
["SCAT",82.29,"-16,95 to 181,5","No","ns","0.0617"]
["IAAT",296.39999999999998,"197,2 to 395,7","Yes","****","<0.0001"]
[]
["Test details","Mean 1","Mean 2","Mean Diff,","SE of diff,","N1","N2","t","DF"]
[]
["WT - KO"]
["SCAT",746.3,664,82.29,43.09,14,14,1.91,52]
["IAAT",549.4,252.9,296.39999999999998,43.09,14,14,6.8789999999999996,52]

{"sheet":"Fig. 6a","index":5,"n_rows":36,"n_cols":9,"rows_kept":36,"cut":false,"hidden":false,"merged":[]}
["Two-way RM ANOVA","Matching: Stacked"]
["Alpha",0.05]
[]
["Source of Variation","% of total variation","P value","P value summary","Significant?"]
["Interaction",0.40760000000000002,0.41610000000000003,"ns","No"]
["Treatment",70.540000000000006,"< 0,0001","****","Yes"]
["Genotype",2.8809999999999998,3.27E-2,"*","Yes"]
["Subjects (matching)",12.82,0.56000000000000005,"ns","No"]
[]
["ANOVA table","SS","DF","MS","F (DFn, DFd)","P value"]
["Interaction",91.44,1,91.44,"F (1, 23) = 0,6860","P = 0,4161"]
["Treatment",15825,1,15825,"F (1, 23) = 118,7","P < 0,0001"]
["Genotype",646.4,1,646.4,"F (1, 23) = 5,168","P = 0,0327"]
["Subjects (matching)",2877,23,125.1,"F (23, 23) = 0,9384","P = 0,5600"]
["Residual",3066,23,133.30000000000001]
[]
["Compare each cell mean with the other cell mean in that row."]
[]
["Number of missing values",0]
[]
["Number of families",1]
["Number of comparisons per family",2]
["Alpha",0.05]
[]
["Uncorrected Fisher's LSD","Mean Diff,","95% CI of diff,","Significant?","Summary","Individual P Value"]
[]
["WT - KO"]
["0 min",-4.49,"-13,65 to 4,669","No","ns",0.32890000000000003]
["ISO 15min",-9.9039999999999999,"-19,06 to -0,7450","Yes","*",3.4700000000000002E-2]
[]
[]
["Test details","Mean 1","Mean 2","Mean Diff,","SE of diff,","N1","N2","t","DF"]
[]
["WT - KO"]
["0 min",34.21,38.700000000000003,-4.49,4.55,13,12,0.9869,46]
["ISO 15min",67.12,77.02,-9.9039999999999999,4.55,13,12,2.177,46]

{"sheet":"Fig. 6b","index":6,"n_rows":27,"n_cols":7,"rows_kept":27,"cut":false,"hidden":false,"merged":[]}
["Three-way ANOVA","RM"]
["Alpha",0.05]
[]
["  ","Num. df ","Den. df ","F-value ","p-value"]
["Genotype ",1,28,"21.72 ","< 0.0001 "]
["Treatment ",1,28,"257.76 ","< 0.0001 "]
["Time ",5,140,"722.08 ","< 0.0001 "]
["Genotype * Treatment ",1,28,"0.49 ","0.4884 "]
["Genotype * Time ",5,140,"20.70 ","< 0.0001 "]
["Treatment * Time ",5,140,"170.72 ","< 0.0001 "]
["Genotype * Treatment * Time ",5,140,"0.76 ","0.5818 "]
[]
["Compare each cell mean with the other cell mean in that row."]
[]
["Sidak's Comparison ","Difference ","Lower 95% CI ","Upper 95% CI ","Std error ","p-value ","Significance"]
["KO,control,0 vs. WT,control,0 ","-0.013 ","-0.844 ","0.819 ","0.421 ","0.9759 "]
["KO,control,60 vs. WT,control,60 ","0.290 ","-0.541 ","1.122 ","0.421 ","0.4910 "]
["KO,control,90 vs. WT,control,90 ","0.608 ","-0.223 ","1.440 ","0.421 ","0.1502 "]
["KO,control,120 vs. WT,control,120 ","1.173 ","0.342 ","2.004 ","0.421 ","0.0060 ","**"]
["KO,control,150 vs. WT,control,150 ","1.852 ","1.021 ","2.684 ","0.421 ","< 0.0001 ","****"]
["KO,control,180 vs. WT,control,180 ","1.912 ","1.081 ","2.743 ","0.421 ","< 0.0001 ","****"]
["KO,treatment,0 vs. WT,treatment,0 ","-0.024 ","-0.855 ","0.808 ","0.421 ","0.9547 "]
["KO,treatment,60 vs. WT,treatment,60 ","1.195 ","0.363 ","2.026 ","0.421 ","0.0052 ","**"]
["KO,treatment,90 vs. WT,treatment,90 ","0.793 ","-0.039 ","1.624 ","0.421 ","0.0615 "]
["KO,treatment,120 vs. WT,treatment,120 ","1.324 ","0.492 ","2.155 ","0.421 ","0.0020 ","**"]
["KO,treatment,150 vs. WT,treatment,150 ","2.290 ","1.458 ","3.121 ","0.421 ","< 0.0001 ","****"]
["KO,treatment,180 vs. WT,treatment,180 ","2.312 ","1.481 ","3.144 ","0.421 ","< 0.0001 ","****"]

{"sheet":"Fig. 6c","index":7,"n_rows":34,"n_cols":9,"rows_kept":34,"cut":false,"hidden":false,"merged":[]}
["Two-way ANOVA","Ordinary"]
["Alpha",0.05]
[]
["Source of Variation","% of total variation","P value","P value summary","Significant?"]
["Interaction",10.42,1.0200000000000001E-2,"*","Yes"]
["Treatment",55.46,"< 0,0001","****","Yes"]
["Genotype",8.2059999999999995,2.0500000000000001E-2,"*","Yes"]
[{"$nulls":7},"P = 0,0102"]
["ANOVA table","SS","DF","MS","F (DFn, DFd)","P value",null,"P < 0,0001"]
["Interaction",3.3919999999999999,1,3.3919999999999999,"F (1, 20) = 8,039","P = 0,0102",null,"P = 0,0205"]
["Treatment",18.059999999999999,1,18.059999999999999,"F (1, 20) = 42,81","P < 0,0001"]
["Genotype",2.673,1,2.673,"F (1, 20) = 6,333","P = 0,0205"]
["Residual",8.44,20,0.42199999999999999]
[]
["Number of missing values",0]
[]
["Compare each cell mean with the other cell mean in that row."]
[]
["Number of families",1]
["Number of comparisons per family",2]
["Alpha",0.05]
[]
["Uncorrected Fisher's LSD","Mean Diff,","95% CI of diff,","Significant?","Summary","Individual P Value"]
[]
["WT - KO"]
["Vehicle",8.4519999999999998E-2,"-0,6978 to 0,8669","No","ns",0.82399999999999995]
["Iso 1 mM",-1.419,"-2,202 to -0,6370","Yes","**",1.1999999999999999E-3]
[]
[]
["Test details","Mean 1","Mean 2","Mean Diff,","SE of diff,","N1","N2","t","DF"]
[]
["WT - KO"]
["Vehicle",1.1519999999999999,1.0669999999999999,8.4519999999999998E-2,0.37509999999999999,6,6,0.2253,20]
["Iso 1 mM",2.1349999999999998,3.5539999999999998,-1.419,0.37509999999999999,6,6,3.7839999999999998,20]

{"sheet":"Fig. 6d","index":8,"n_rows":122,"n_cols":9,"rows_kept":122,"cut":false,"hidden":false,"merged":[]}
["TG"]
[]
["Two-way ANOVA","Ordinary"]
["Alpha",0.05]
[]
["Source of Variation","% of total variation","P value","P value summary","Significant?"]
["Interaction",1.145,0.92390000000000005,"ns","No"]
["Time",40.35,4.8999999999999998E-3,"**","Yes"]
["siRNA",0.25669999999999998,0.74780000000000002,"ns","No"]
[]
["ANOVA table","SS","DF","MS","F (DFn, DFd)","P value"]
["Interaction",2.0140000000000002E-2,3,6.7120000000000001E-3,"F (3, 24) = 0,1573","P = 0,9239"]
["Time",0.70950000000000002,3,0.23649999999999999,"F (3, 24) = 5,543","P = 0,0049"]
["siRNA",4.5129999999999997E-3,1,4.5129999999999997E-3,"F (1, 24) = 0,1058","P = 0,7478"]
["Residual",1.024,24,4.267E-2]
[]
["Number of missing values",0]
[]
["Compare each cell mean with the other cell mean in that row."]
[]
["Number of families",1]
["Number of comparisons per family",4]
["Alpha",0.05]
[]
["Sidak's multiple comparisons test","Mean Diff,","95% CI of diff,","Significant?","Summary"]
[]
["siCtl - siFMR1"]
["    0",-2.5000000000000001E-3,"-0,3957 to 0,3907","No","ns"]
["    30",2.75E-2,"-0,3657 to 0,4207","No","ns"]
["    60",-3.2500000000000001E-2,"-0,4257 to 0,3607","No","ns"]
["    120",0.10249999999999999,"-0,2907 to 0,4957","No","ns"]
[]
["Test details","Mean 1","Mean 2","Mean Diff,","SE of diff,","N1","N2","t","DF"]
[]
["siCtl - siFMR1"]
["    0",1,1.0029999999999999,-2.5000000000000001E-3,0.14610000000000001,4,4,1.712E-2,24]
["    30",0.63249999999999995,0.60499999999999998,2.75E-2,0.14610000000000001,4,4,0.1883,24]
["    60",0.78,0.8125,-3.2500000000000001E-2,0.14610000000000001,4,4,0.2225,24]
["    120",1,0.89749999999999996,0.10249999999999999,0.14610000000000001,4,4,0.70179999999999998,24]
[]
["Glycerol"]
[]
["Two-way ANOVA","Ordinary"]
["Alpha",0.05]
[]
["Source of Variation","% of total variation","P value","P value summary","Significant?"]
["Interaction",6.6790000000000003,4.7999999999999996E-3,"**","Yes"]
["Time",80.63,"< 0,0001","****","Yes"]
["siRNA",3.1030000000000002,1.0200000000000001E-2,"*","Yes"]
[]
["ANOVA table","SS","DF","MS","F (DFn, DFd)","P value"]
["Interaction",3.8140000000000001,3,1.2709999999999999,"F (3, 24) = 5,573","P = 0,0048"]
["Time",46.04,3,15.35,"F (3, 24) = 67,27","P < 0,0001"]
["siRNA",1.772,1,1.772,"F (1, 24) = 7,768","P = 0,0102"]
["Residual",5.4749999999999996,24,0.2281]
[]
["Number of missing values",0]
[]
["Compare each cell mean with the other cell mean in that row."]
[]
["Number of families",1]
["Number of comparisons per family",4]
["Alpha",0.05]
[]
["Compare each cell mean with the other cell mean in that row."]
[]
["Sidak's multiple comparisons test","Mean Diff,","95% CI of diff,","Significant?","Summary"]
[]
["siCtl - siFMR1"]
["    0",2.2350000000000002E-8,"-0,9091 to 0,9091","No","ns"]
["    30",0.24,"-0,6691 to 1,149","No","ns"]
["    60",-0.56999999999999995,"-1,479 to 0,3391","No","ns"]
["    120",-1.5529999999999999,"-2,462 to -0,6434","Yes","***"]
[]
[]
["Test details","Mean 1","Mean 2","Mean Diff,","SE of diff,","N1","N2","t","DF"]
[]
["siCtl - siFMR1"]
["    0",0.99750000000000005,0.99750000000000005,2.2350000000000002E-8,0.3377,4,4,6.6180000000000001E-8,24]
["    30",1.06,0.82,0.24,0.3377,4,4,0.71060000000000001,24]
["    60",1.6379999999999999,2.2080000000000002,-0.56999999999999995,0.3377,4,4,1.6879999999999999,24]
["    120",3.13,4.6829999999999998,-1.5529999999999999,0.3377,4,4,4.5970000000000004,24]
[]
["FFA"]
[]
["Two-way ANOVA","Ordinary"]
["Alpha",0.05]
[]
["Source of Variation","% of total variation","P value","P value summary","Significant?"]
["Interaction",16.739999999999998,8.0999999999999996E-3,"**","Yes"]
["Time",39.6,"< 0,0001","****","Yes"]
["siRNA",16.649999999999999,8.0000000000000004E-4,"***","Yes"]
[]
["ANOVA table","SS","DF","MS","F (DFn, DFd)","P value"]
["Interaction",1.34,3,0.44669999999999999,"F (3, 24) = 4,958","P = 0,0081"]
["Time",3.17,3,1.0569999999999999,"F (3, 24) = 11,73","P < 0,0001"]
["siRNA",1.333,1,1.333,"F (1, 24) = 14,79","P = 0,0008"]
["Residual",2.1629999999999998,24,9.0109999999999996E-2]
[]
["Number of missing values",0]
[]
["Compare each cell mean with the other cell mean in that row."]
[]
["Number of families",1]
["Number of comparisons per family",4]
["Alpha",0.05]
[]
["Sidak's multiple comparisons test","Mean Diff,","95% CI of diff,","Significant?","Summary"]
[]
["siCtl - siFMR1"]
["    0",1.4899999999999999E-8,"-0,5714 to 0,5714","No","ns"]
["    30",1.4899999999999999E-8,"-0,5714 to 0,5714","No","ns"]
["    60",-0.86,"-1,431 to -0,2886","Yes","**"]
["    120",-0.77249999999999996,"-1,344 to -0,2011","Yes","**"]
[]
["Test details","Mean 1","Mean 2","Mean Diff,","SE of diff,","N1","N2","t","DF"]
[]
["siCtl - siFMR1"]
["    0",1,1,1.4899999999999999E-8,0.21229999999999999,4,4,7.0200000000000007E-8,24]
["    30",1,1,1.4899999999999999E-8,0.21229999999999999,4,4,7.0200000000000007E-8,24]
["    60",1.073,1.9330000000000001,-0.86,0.21229999999999999,4,4,4.0519999999999996,24]
["    120",1.333,2.105,-0.77249999999999996,0.21229999999999999,4,4,3.6389999999999998,24]

{"sheet":"Fig. S8","index":9,"n_rows":36,"n_cols":9,"rows_kept":36,"cut":false,"hidden":false,"merged":[]}
["Two-way ANOVA","Ordinary"]
["Alpha",0.05]
[]
["Source of Variation","% of total variation","P value","P value summary","Significant?"]
["Interaction",19.63,1.44E-2,"*","Yes"]
["Transcript",19.63,1.44E-2,"*","Yes"]
["siRNA",28.11,1E-3,"***","Yes"]
[]
["ANOVA table","SS","DF","MS","F (DFn, DFd)","P value"]
["Interaction",0.44269999999999998,2,0.2213,"F (2, 18) = 5,414","P = 0,0144"]
["Transcript",0.44269999999999998,2,0.2213,"F (2, 18) = 5,414","P = 0,0144"]
["siRNA",0.63390000000000002,1,0.63390000000000002,"F (1, 18) = 15,51","P = 0,0010"]
["Residual",0.73580000000000001,18,4.088E-2]
[]
["Number of missing values",0]
[]
["Compare each cell mean with the other cell mean in that row."]
[]
["Number of families",1]
["Number of comparisons per family",3]
["Alpha",0.05]
[]
["Sidak's multiple comparisons test","Mean Diff,","95% CI of diff,","Significant?","Summary"]
[]
["siCtl - siFMR1"]
["FMR1",0.69799999999999995,"0,3219 to 1,074","Yes","***"]
["PLIN1",0.218,"-0,1582 to 0,5941","No","ns"]
["FABP4",5.9080000000000001E-2,"-0,3171 to 0,4352","No","ns"]
[]
[]
["Test details","Mean 1","Mean 2","Mean Diff,","SE of diff,","N1","N2","t","DF"]
[]
["siCtl - siFMR1"]
["FMR1",1,0.30199999999999999,0.69799999999999995,0.14299999999999999,4,4,4.883,18]
["PLIN1",1,0.78200000000000003,0.218,0.14299999999999999,4,4,1.5249999999999999,18]
["FABP4",1,0.94089999999999996,5.9080000000000001E-2,0.14299999999999999,4,4,0.41320000000000001,18]